ABHD17A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of cell killing (GO:0031342)5.30873461
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.30873461
3antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.16219419
4negative regulation of erythrocyte differentiation (GO:0045647)5.06543739
5antigen processing and presentation of endogenous antigen (GO:0019883)4.86633443
6antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.79459376
7antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.72224060
8positive regulation of gamma-delta T cell activation (GO:0046645)4.58844167
9erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.39603247
10L-phenylalanine metabolic process (GO:0006558)4.39603247
11leukocyte aggregation (GO:0070486)4.33247747
12positive thymic T cell selection (GO:0045059)4.32116787
13positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.26709186
14regulation of B cell receptor signaling pathway (GO:0050855)4.10645348
15sulfur amino acid catabolic process (GO:0000098)3.96763728
16L-phenylalanine catabolic process (GO:0006559)3.95484337
17erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.95484337
18thymic T cell selection (GO:0045061)3.94314824
19positive regulation by symbiont of host defense response (GO:0052509)3.88515854
20modulation by symbiont of host defense response (GO:0052031)3.88515854
21modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.88515854
22modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.88515854
23positive regulation by organism of defense response of other organism involved in symbiotic interact3.88515854
24modulation by symbiont of host immune response (GO:0052553)3.88515854
25alpha-linolenic acid metabolic process (GO:0036109)3.86707772
26regulation of cholesterol homeostasis (GO:2000188)3.75045528
27detection of bacterium (GO:0016045)3.73829614
28cysteine metabolic process (GO:0006534)3.68497380
29glyoxylate metabolic process (GO:0046487)3.67901831
30macrophage activation involved in immune response (GO:0002281)3.66120609
31detection of other organism (GO:0098543)3.65719154
32triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.63589056
33maternal placenta development (GO:0001893)3.63059005
34negative regulation of cholesterol transport (GO:0032375)3.61573865
35negative regulation of sterol transport (GO:0032372)3.61573865
36negative thymic T cell selection (GO:0045060)3.56091488
37T cell selection (GO:0045058)3.48756458
38regulation of gamma-delta T cell activation (GO:0046643)3.46904608
39mannose metabolic process (GO:0006013)3.46584363
40pentose-phosphate shunt (GO:0006098)3.46411793
41positive T cell selection (GO:0043368)3.46234828
42synaptic vesicle maturation (GO:0016188)3.44740304
43negative regulation of cell size (GO:0045792)3.44280078
44negative T cell selection (GO:0043383)3.39377370
45response to muramyl dipeptide (GO:0032495)3.39277915
46CDP-diacylglycerol metabolic process (GO:0046341)3.37226818
47regulation of early endosome to late endosome transport (GO:2000641)3.36624539
48regulation of gamma-delta T cell differentiation (GO:0045586)3.34770947
49positive regulation of triglyceride biosynthetic process (GO:0010867)3.34354079
50lysine metabolic process (GO:0006553)3.31011327
51lysine catabolic process (GO:0006554)3.31011327
52negative regulation of phagocytosis (GO:0050765)3.30459678
53regulation of fatty acid beta-oxidation (GO:0031998)3.29762753
54positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.27952936
55neutrophil activation involved in immune response (GO:0002283)3.25214454
56negative regulation of fibrinolysis (GO:0051918)3.24527137
57negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.18177787
58positive regulation of triglyceride metabolic process (GO:0090208)3.18114850
59sodium ion export (GO:0071436)3.17644851
60aspartate family amino acid catabolic process (GO:0009068)3.15682604
61cellular modified amino acid catabolic process (GO:0042219)3.14697408
62glycine metabolic process (GO:0006544)3.12359727
63glutamate metabolic process (GO:0006536)3.10754440
64negative regulation of leukocyte mediated immunity (GO:0002704)3.07391607
65B cell receptor signaling pathway (GO:0050853)3.06395803
66positive regulation of Rap GTPase activity (GO:0032854)3.04491988
67serine family amino acid biosynthetic process (GO:0009070)3.03958304
68regulation of mast cell degranulation (GO:0043304)3.03808936
69tolerance induction (GO:0002507)3.03753456
70response to peptidoglycan (GO:0032494)3.03027780
71signal complex assembly (GO:0007172)3.02539676
72NADPH regeneration (GO:0006740)3.01537429
73CDP-diacylglycerol biosynthetic process (GO:0016024)3.01229636
74negative regulation of lymphocyte mediated immunity (GO:0002707)3.00697126
75response to laminar fluid shear stress (GO:0034616)2.99803418
76regulation of leukocyte degranulation (GO:0043300)2.99720640
77serine family amino acid metabolic process (GO:0009069)2.96376581
78cellular ketone body metabolic process (GO:0046950)2.95176011
79regulation of ARF protein signal transduction (GO:0032012)2.92762240
80NIK/NF-kappaB signaling (GO:0038061)2.92232391
81modulation by virus of host process (GO:0019054)2.92160696
82serine family amino acid catabolic process (GO:0009071)2.91546917
83response to interleukin-15 (GO:0070672)2.91253362
84regulation of myeloid leukocyte mediated immunity (GO:0002886)2.91080332
85T cell migration (GO:0072678)2.90103305
86negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.89628792
87heme transport (GO:0015886)2.88750897
88acetyl-CoA metabolic process (GO:0006084)2.88636069
89DNA deamination (GO:0045006)2.87220535
90fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.86939075
91detection of external biotic stimulus (GO:0098581)2.86249761
92negative regulation of interleukin-12 production (GO:0032695)2.86111212
93positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.85460709
94positive regulation of lipoprotein lipase activity (GO:0051006)2.84887644
95positive regulation of triglyceride lipase activity (GO:0061365)2.84887644
96ethanol oxidation (GO:0006069)2.83508840
97bile acid biosynthetic process (GO:0006699)2.83465342
98aromatic amino acid family catabolic process (GO:0009074)2.83052146
99regulation of natural killer cell mediated immunity (GO:0002715)2.82730545
100regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.82730545
101modulation by symbiont of host cellular process (GO:0044068)2.81999454
102positive regulation of histone deacetylation (GO:0031065)2.81416039
103germinal center formation (GO:0002467)2.80392099
104response to mercury ion (GO:0046689)2.80347189
105high-density lipoprotein particle remodeling (GO:0034375)2.79711643
106sexual reproduction (GO:0019953)2.79098555
107regulation of T cell tolerance induction (GO:0002664)2.78054914
108urea metabolic process (GO:0019627)2.75794990
109urea cycle (GO:0000050)2.75794990
110locomotory exploration behavior (GO:0035641)2.75358602
1112-oxoglutarate metabolic process (GO:0006103)2.75050055
112galactose catabolic process (GO:0019388)2.74623420
113nucleotide salvage (GO:0043173)2.74599902
114sterol catabolic process (GO:0016127)2.73575264
115cholesterol catabolic process (GO:0006707)2.73575264
116cellular extravasation (GO:0045123)2.72844247
117phosphate ion transmembrane transport (GO:0035435)2.72098917
118acylglycerol catabolic process (GO:0046464)2.72070755
119neutral lipid catabolic process (GO:0046461)2.72070755
120regulation of extracellular matrix disassembly (GO:0010715)2.69748557
121glutamate secretion (GO:0014047)2.69358843
122kynurenine metabolic process (GO:0070189)2.68765681
123antigen processing and presentation via MHC class Ib (GO:0002475)2.67624580
124regulation of triglyceride catabolic process (GO:0010896)2.67288972
125layer formation in cerebral cortex (GO:0021819)2.66980969
126response to type I interferon (GO:0034340)2.66809863
127regulation of ARF GTPase activity (GO:0032312)2.65760002
128flavonoid metabolic process (GO:0009812)2.65681814
129regulation of mast cell activation involved in immune response (GO:0033006)2.63416309
130ethanol metabolic process (GO:0006067)2.63109579
131type I interferon signaling pathway (GO:0060337)2.62766279
132cellular response to type I interferon (GO:0071357)2.62766279
133L-serine metabolic process (GO:0006563)2.61696448
134regulation of T-helper 2 cell differentiation (GO:0045628)2.61367454
135amino-acid betaine metabolic process (GO:0006577)2.60808825
1364-hydroxyproline metabolic process (GO:0019471)2.60513703
137regulation of interferon-beta biosynthetic process (GO:0045357)2.60409619
138regulation of regulated secretory pathway (GO:1903305)2.60287034
139nitrogen cycle metabolic process (GO:0071941)2.60216046
140immunoglobulin mediated immune response (GO:0016064)2.60052676
141activated T cell proliferation (GO:0050798)2.60047437
142regulation of defense response to virus by virus (GO:0050690)2.59766773
143negative regulation of innate immune response (GO:0045824)2.59029140
144positive regulation of fatty acid biosynthetic process (GO:0045723)2.58987264
145dicarboxylic acid biosynthetic process (GO:0043650)2.58943578
146dicarboxylic acid catabolic process (GO:0043649)2.58899827
147regulation of translational termination (GO:0006449)2.58258439
148positive regulation of B cell differentiation (GO:0045579)2.57627750
149iron coordination entity transport (GO:1901678)2.57193912
150myeloid cell activation involved in immune response (GO:0002275)2.55991213
151glutamine family amino acid biosynthetic process (GO:0009084)2.55505557
152regulation of short-term neuronal synaptic plasticity (GO:0048172)2.54617139
153negative regulation of T cell mediated immunity (GO:0002710)2.54616342
154positive regulation of lamellipodium assembly (GO:0010592)2.54147559
155positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.53963373
156plasma lipoprotein particle clearance (GO:0034381)2.53610398
157barbed-end actin filament capping (GO:0051016)2.53238104
158negative regulation of lipid transport (GO:0032369)2.52887269
159cellular amino acid catabolic process (GO:0009063)2.52745213
160tricarboxylic acid metabolic process (GO:0072350)2.51792295
161positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.51654087
162regulation of type I interferon-mediated signaling pathway (GO:0060338)2.51470385
163regulation of fatty acid oxidation (GO:0046320)2.51400805
164short-chain fatty acid metabolic process (GO:0046459)2.51192094
165cellular response to interleukin-15 (GO:0071350)2.50893896
166regulation of dendritic cell antigen processing and presentation (GO:0002604)2.50887218
167lipopolysaccharide-mediated signaling pathway (GO:0031663)2.50754328
168protein insertion into membrane (GO:0051205)2.50607224
169regulation of B cell differentiation (GO:0045577)2.50226601
170viral transcription (GO:0019083)2.50201690
171alpha-amino acid catabolic process (GO:1901606)2.50195423
172negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.50022805
173activation of protein kinase A activity (GO:0034199)2.49473907
174protein localization to endosome (GO:0036010)2.48570155
175phosphate ion transport (GO:0006817)2.48120824
176detection of biotic stimulus (GO:0009595)2.47305986
177negative regulation of type 2 immune response (GO:0002829)2.46054247
178myeloid dendritic cell differentiation (GO:0043011)2.45801870
179triglyceride catabolic process (GO:0019433)2.45701099
180regulation of cholesterol esterification (GO:0010872)2.44983443
181regulation of fatty acid biosynthetic process (GO:0042304)2.44964879
182ketone body metabolic process (GO:1902224)2.44962846
183regulation of cholesterol metabolic process (GO:0090181)2.44585720
184protein retention in ER lumen (GO:0006621)2.44400270
185regulation of cholesterol biosynthetic process (GO:0045540)2.43852577
186regulation of fibrinolysis (GO:0051917)2.43832260
187regulation of macrophage cytokine production (GO:0010935)2.43323081
188cytoskeletal anchoring at plasma membrane (GO:0007016)2.43293598
189regulation of Rap GTPase activity (GO:0032317)2.42986086
190negative regulation of toll-like receptor signaling pathway (GO:0034122)2.42650717
191regulation of tolerance induction (GO:0002643)2.42453881
192activation of JUN kinase activity (GO:0007257)2.41716466
193defense response to protozoan (GO:0042832)2.41096341
194response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.40346137
195response to host immune response (GO:0052572)2.40346137
196positive regulation of protein deacetylation (GO:0090312)2.40178340
197positive regulation of protein dephosphorylation (GO:0035307)2.37857093
198respiratory burst (GO:0045730)2.36622708
199response to host defenses (GO:0052200)2.35886708

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.17628376
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.47657190
3RXR_22158963_ChIP-Seq_LIVER_Mouse2.95652124
4ZNF263_19887448_ChIP-Seq_K562_Human2.86867056
5LXR_22292898_ChIP-Seq_THP-1_Human2.84070459
6PPARA_22158963_ChIP-Seq_LIVER_Mouse2.82663608
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.79480374
8MYC_22102868_ChIP-Seq_BL_Human2.49637478
9IRF8_22096565_ChIP-ChIP_GC-B_Human2.30255774
10SRY_22984422_ChIP-ChIP_TESTIS_Rat2.25188454
11KDM2B_26808549_Chip-Seq_SUP-B15_Human2.17616024
12VDR_21846776_ChIP-Seq_THP-1_Human2.14147933
13TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.13709186
14MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.13686806
15MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.13652947
16BP1_19119308_ChIP-ChIP_Hs578T_Human2.09225112
17KDM2B_26808549_Chip-Seq_DND41_Human2.07514502
18STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.05150852
19ELK3_25401928_ChIP-Seq_HUVEC_Human2.04732226
20ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.01787134
21THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.99862219
22RACK7_27058665_Chip-Seq_MCF-7_Human1.92213031
23LXR_22158963_ChIP-Seq_LIVER_Mouse1.91243929
24KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.90622628
25VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.83711846
26RUNX1_22412390_ChIP-Seq_EML_Mouse1.82305148
27TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.82085612
28FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.80531371
29TET1_21451524_ChIP-Seq_MESCs_Mouse1.78168407
30EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.77005165
31SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.76343291
32P68_20966046_ChIP-Seq_HELA_Human1.75944371
33TCF7_22412390_ChIP-Seq_EML_Mouse1.74304949
34TP63_17297297_ChIP-ChIP_HaCaT_Human1.72080256
35STAT6_21828071_ChIP-Seq_BEAS2B_Human1.68989161
36BRD4_27068464_Chip-Seq_AML-cells_Mouse1.68391788
37ZFP281_18757296_ChIP-ChIP_E14_Mouse1.67024578
38ELF1_20517297_ChIP-Seq_JURKAT_Human1.63511649
39BCOR_27268052_Chip-Seq_Bcells_Human1.61165850
40NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.60921269
41BCL6_27268052_Chip-Seq_Bcells_Human1.60315363
42TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.58759328
43SA1_27219007_Chip-Seq_ERYTHROID_Human1.58620097
44DNAJC2_21179169_ChIP-ChIP_NT2_Human1.57575219
45SCL_19346495_ChIP-Seq_HPC-7_Human1.57499204
46RARG_19884340_ChIP-ChIP_MEFs_Mouse1.56824299
47KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.56032837
48NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.56012654
49NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.55892562
50SPI1_23127762_ChIP-Seq_K562_Human1.54084770
51KDM2B_26808549_Chip-Seq_K562_Human1.53281765
52EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.53233212
53E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.48359286
54SMC4_20622854_ChIP-Seq_HELA_Human1.47372084
55EGR1_19374776_ChIP-ChIP_THP-1_Human1.47308810
56RUNX_20019798_ChIP-Seq_JUKART_Human1.46994631
57ATF3_27146783_Chip-Seq_COLON_Human1.45107355
58MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.43906652
59CREB1_26743006_Chip-Seq_LNCaP_Human1.42927184
60FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.40576238
61STAT3_1855785_ChIP-Seq_MESCs_Mouse1.39031839
62SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.38337627
63SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.37650313
64IRF8_27001747_Chip-Seq_BMDM_Mouse1.37354567
65CTCF_21964334_ChIP-Seq_BJAB-B_Human1.36258750
66SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.35042436
67SA1_27219007_Chip-Seq_Bcells_Human1.34966182
68NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.34760052
69PHF8_20622854_ChIP-Seq_HELA_Human1.34446415
70ERG_21242973_ChIP-ChIP_JURKAT_Human1.34116887
71STAT4_19710469_ChIP-ChIP_TH1__Mouse1.33826637
72KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.33657361
73MYB_21317192_ChIP-Seq_ERMYB_Mouse1.33161101
74CTCF_27219007_Chip-Seq_Bcells_Human1.32442480
75CTCF_27219007_Chip-Seq_ERYTHROID_Human1.30687052
76IRF8_21731497_ChIP-ChIP_J774_Mouse1.29591902
77UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.29221975
78IKZF1_21737484_ChIP-ChIP_HCT116_Human1.28786096
79CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.28711520
80PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.27449749
81CTCF_21964334_Chip-Seq_Bcells_Human1.27218458
82DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.26435535
83FOXP1_21924763_ChIP-Seq_HESCs_Human1.26342942
84CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.25502319
85KDM2B_26808549_Chip-Seq_JURKAT_Human1.23419169
86TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.23321832
87YY1_22570637_ChIP-Seq_MALME-3M_Human1.22773541
88SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.22266458
89RARB_27405468_Chip-Seq_BRAIN_Mouse1.22030737
90RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.21201911
91SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.20481242
92E2F1_20622854_ChIP-Seq_HELA_Human1.20165987
93PU.1_20513432_ChIP-Seq_Bcells_Mouse1.20081224
94MAF_26560356_Chip-Seq_TH2_Human1.19680900
95UTX_26944678_Chip-Seq_JUKART_Human1.19563372
96TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.19562776
97CTCF_18555785_ChIP-Seq_MESCs_Mouse1.19337946
98IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.18820790
99MAF_26560356_Chip-Seq_TH1_Human1.18516718
100MYB_26560356_Chip-Seq_TH1_Human1.18513000
101ESR2_21235772_ChIP-Seq_MCF-7_Human1.17190578
102SPI1_23547873_ChIP-Seq_NB4_Human1.16841157
103P300_27058665_Chip-Seq_ZR-75-30cells_Human1.16806713
104GATA1_22383799_ChIP-Seq_G1ME_Mouse1.16754572
105RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.16705807
106SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.15988462
107CTCF_26484167_Chip-Seq_Bcells_Mouse1.15919306
108CTCF_20526341_ChIP-Seq_ESCs_Human1.14854372
109MYB_26560356_Chip-Seq_TH2_Human1.14506759
110GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12450880
111KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.11908615
112KLF4_18555785_ChIP-Seq_MESCs_Mouse1.10343612
113TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.10160525
114CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.09249940
115CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.09040878
116GATA1_19941826_ChIP-Seq_K562_Human1.08644823
117PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.08327870
118TP63_22573176_ChIP-Seq_HFKS_Human1.07979711
119LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.07306483
120SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.07067347
121POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.06845891
122MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.06313130
123DROSHA_22980978_ChIP-Seq_HELA_Human1.06113562
124GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.05793780
125TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.05228906
126NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.04846965
127ZFP281_27345836_Chip-Seq_ESCs_Mouse1.04797039
128GATA1_19941827_ChIP-Seq_MEL_Mouse1.03758053
129VDR_24763502_ChIP-Seq_THP-1_Human1.03613567
130STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.03288993
131KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.98728601
132SPI1_20517297_ChIP-Seq_HL60_Human0.97874628
133ETS1_21867929_ChIP-Seq_TH2_Mouse0.97661126
134TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.97273192
135RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.97144864
136TP53_22127205_ChIP-Seq_IMR90_Human0.96323922
137SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.96254069
138ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.95738691
139NCOR1_26117541_ChIP-Seq_K562_Human0.94134807
140CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.93688885

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009840_abnormal_foam_cell4.60391598
2MP0005360_urolithiasis4.55544024
3MP0002139_abnormal_hepatobiliary_system4.20710508
4MP0003436_decreased_susceptibility_to3.82516796
5MP0004859_abnormal_synaptic_plasticity3.44224021
6MP0005085_abnormal_gallbladder_physiolo3.32824277
7MP0003705_abnormal_hypodermis_morpholog3.20774365
8MP0003806_abnormal_nucleotide_metabolis2.91277479
9MP0005365_abnormal_bile_salt2.85764016
10MP0003724_increased_susceptibility_to2.83208585
11MP0003763_abnormal_thymus_physiology2.76667091
12MP0003329_amyloid_beta_deposits2.60595919
13MP0006082_CNS_inflammation2.59171221
14MP0005671_abnormal_response_to2.58450142
15MP0003191_abnormal_cellular_cholesterol2.57697208
16MP0008875_abnormal_xenobiotic_pharmacok2.54588445
17MP0010234_abnormal_vibrissa_follicle2.51174993
18MP0005083_abnormal_biliary_tract2.49009932
19MP0003172_abnormal_lysosome_physiology2.44553667
20MP0001800_abnormal_humoral_immune2.42630587
21MP0005000_abnormal_immune_tolerance2.42333853
22MP0001835_abnormal_antigen_presentation2.42188189
23MP0005025_abnormal_response_to2.37491544
24MP0002419_abnormal_innate_immunity2.34656649
25MP0005387_immune_system_phenotype2.30788427
26MP0001790_abnormal_immune_system2.30788427
27MP0010329_abnormal_lipoprotein_level2.29236543
28MP0009333_abnormal_splenocyte_physiolog2.16656910
29MP0002420_abnormal_adaptive_immunity2.10955408
30MP0002723_abnormal_immune_serum2.10830337
31MP0004947_skin_inflammation2.10721261
32MP0003303_peritoneal_inflammation2.10676646
33MP0001819_abnormal_immune_cell2.08258520
34MP0002822_catalepsy2.06292663
35MP0002452_abnormal_antigen_presenting2.03869992
36MP0008260_abnormal_autophagy2.03228395
37MP0001666_abnormal_nutrient_absorption1.93034826
38MP0004858_abnormal_nervous_system1.92691426
39MP0003252_abnormal_bile_duct1.90280226
40MP0005332_abnormal_amino_acid1.84835638
41MP0001533_abnormal_skeleton_physiology1.84047916
42MP0003690_abnormal_glial_cell1.83883966
43MP0003300_gastrointestinal_ulcer1.81601061
44MP0005464_abnormal_platelet_physiology1.80718917
45MP0009785_altered_susceptibility_to1.75556048
46MP0010155_abnormal_intestine_physiology1.74447251
47MP0001873_stomach_inflammation1.73910111
48MP0002398_abnormal_bone_marrow1.69734327
49MP0000604_amyloidosis1.67850124
50MP0003075_altered_response_to1.66277279
51MP0002405_respiratory_system_inflammati1.65311301
52MP0000716_abnormal_immune_system1.63532701
53MP0002909_abnormal_adrenal_gland1.61482704
54MP0002118_abnormal_lipid_homeostasis1.59983538
55MP0005410_abnormal_fertilization1.57971589
56MP0005167_abnormal_blood-brain_barrier1.56775108
57MP0002933_joint_inflammation1.54705057
58MP0005584_abnormal_enzyme/coenzyme_acti1.54240335
59MP0000858_altered_metastatic_potential1.53732899
60MP0002148_abnormal_hypersensitivity_rea1.50933122
61MP0001851_eye_inflammation1.50563665
62MP0002998_abnormal_bone_remodeling1.50034883
63MP0003656_abnormal_erythrocyte_physiolo1.49560076
64MP0004130_abnormal_muscle_cell1.48275482
65MP0003279_aneurysm1.47996208
66MP0006036_abnormal_mitochondrial_physio1.47831785
67MP0004381_abnormal_hair_follicle1.46744734
68MP0000609_abnormal_liver_physiology1.45156611
69MP0003635_abnormal_synaptic_transmissio1.43193239
70MP0000703_abnormal_thymus_morphology1.41216276
71MP0000747_muscle_weakness1.39753041
72MP0008961_abnormal_basal_metabolism1.37306824
73MP0010352_gastrointestinal_tract_polyps1.37122675
74MP0000465_gastrointestinal_hemorrhage1.34878671
75MP0002722_abnormal_immune_system1.32647636
76MP0001845_abnormal_inflammatory_respons1.32279601
77MP0002429_abnormal_blood_cell1.32004869
78MP0003879_abnormal_hair_cell1.29485027
79MP0003183_abnormal_peptide_metabolism1.28928910
80MP0002089_abnormal_postnatal_growth/wei1.27692409
81MP0005319_abnormal_enzyme/_coenzyme1.26466552
82MP0003828_pulmonary_edema1.25459721
83MP0000689_abnormal_spleen_morphology1.24490532
84MP0004270_analgesia1.21619292
85MP0003453_abnormal_keratinocyte_physiol1.16030875
86MP0001348_abnormal_lacrimal_gland1.15969980
87MP0009643_abnormal_urine_homeostasis1.15757858
88MP0005076_abnormal_cell_differentiation1.14460376
89MP0003195_calcinosis1.12657161
90MP0003091_abnormal_cell_migration1.12621409
91MP0002396_abnormal_hematopoietic_system1.09739652
92MP0003866_abnormal_defecation1.08873842
93MP0004019_abnormal_vitamin_homeostasis1.08465950
94MP0005166_decreased_susceptibility_to1.08215902
95MP0008469_abnormal_protein_level1.08004669
96MP0005409_darkened_coat_color1.07997723
97MP0008874_decreased_physiological_sensi1.06880302
98MP0005310_abnormal_salivary_gland1.06544600
99MP0004185_abnormal_adipocyte_glucose1.06030232
100MP0001849_ear_inflammation1.05692762
101MP0002269_muscular_atrophy1.03719054
102MP0005451_abnormal_body_composition1.00854585
103MP0003283_abnormal_digestive_organ1.00491497
104MP0001958_emphysema0.97828759
105MP0003633_abnormal_nervous_system0.96779824
106MP0002063_abnormal_learning/memory/cond0.94767323
107MP0000490_abnormal_crypts_of0.93656452
108MP0000013_abnormal_adipose_tissue0.93561175
109MP0005666_abnormal_adipose_tissue0.92706491
110MP0003566_abnormal_cell_adhesion0.92405986
111MP0000598_abnormal_liver_morphology0.92366543
112MP0000685_abnormal_immune_system0.92124916
113MP0005330_cardiomyopathy0.91968559
114MP0000678_abnormal_parathyroid_gland0.91564663
115MP0010368_abnormal_lymphatic_system0.91032837
116MP0003448_altered_tumor_morphology0.90369300
117MP0002132_abnormal_respiratory_system0.90239610
118MP0005390_skeleton_phenotype0.90009234
119MP0004885_abnormal_endolymph0.85189401
120MP0000343_altered_response_to0.83809989
121MP0002064_seizures0.83254749
122MP0002796_impaired_skin_barrier0.82826182
123MP0000751_myopathy0.81434224
124MP0003638_abnormal_response/metabolism_0.81007509
125MP0003868_abnormal_feces_composition0.79444256
126MP0000249_abnormal_blood_vessel0.79409516
127MP0005636_abnormal_mineral_homeostasis0.79397515
128MP0000767_abnormal_smooth_muscle0.78945212
129MP0004811_abnormal_neuron_physiology0.78278080
130MP0002653_abnormal_ependyma_morphology0.77613792
131MP0008770_decreased_survivor_rate0.77592572
132MP0005375_adipose_tissue_phenotype0.77451443
133MP0009745_abnormal_behavioral_response0.77321347
134MP0001853_heart_inflammation0.76119875
135MP0004087_abnormal_muscle_fiber0.75950429
136MP0009764_decreased_sensitivity_to0.75528667
137MP0003045_fibrosis0.74984068
138MP0002733_abnormal_thermal_nociception0.74219646
139MP0005381_digestive/alimentary_phenotyp0.73375553
140MP0008569_lethality_at_weaning0.72566803
141MP0004808_abnormal_hematopoietic_stem0.71956482
142MP0004883_abnormal_blood_vessel0.71752374
143MP0006035_abnormal_mitochondrial_morpho0.70615717
144MP0008872_abnormal_physiological_respon0.70046823
145MP0004510_myositis0.69595460
146MP0001730_embryonic_growth_arrest0.69332211
147MP0000477_abnormal_intestine_morphology0.68518684
148MP0002138_abnormal_hepatobiliary_system0.67722004
149MP0003795_abnormal_bone_structure0.67417512
150MP0001545_abnormal_hematopoietic_system0.66363941
151MP0005397_hematopoietic_system_phenotyp0.66363941
152MP0005023_abnormal_wound_healing0.65753638
153MP0006054_spinal_hemorrhage0.64308033
154MP0005058_abnormal_lysosome_morphology0.63355569
155MP0009278_abnormal_bone_marrow0.62291604
156MP0000920_abnormal_myelination0.61777749
157MP0009642_abnormal_blood_homeostasis0.61622582
158MP0004145_abnormal_muscle_electrophysio0.61308181
159MP0005501_abnormal_skin_physiology0.61230782
160MP0004233_abnormal_muscle_weight0.60588364
161MP0001765_abnormal_ion_homeostasis0.60313364
162MP0005535_abnormal_body_temperature0.60077915
163MP0005266_abnormal_metabolism0.59524776
164MP0000003_abnormal_adipose_tissue0.58583511
165MP0001663_abnormal_digestive_system0.58004020
166MP0000358_abnormal_cell_content/0.56302646
167MP0002078_abnormal_glucose_homeostasis0.55721228
168MP0001756_abnormal_urination0.55129617
169MP0001970_abnormal_pain_threshold0.54593258

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)5.47097935
2Abnormality of the Achilles tendon (HP:0005109)4.14355058
3Deep venous thrombosis (HP:0002625)4.13401222
4Achilles tendon contracture (HP:0001771)4.04143149
5Abnormality of aromatic amino acid family metabolism (HP:0004338)3.88637079
6Abnormality of macrophages (HP:0004311)3.78797491
7Recurrent abscess formation (HP:0002722)3.74152371
8Xanthomatosis (HP:0000991)3.72288649
9Myokymia (HP:0002411)3.69616704
10Recurrent bacterial skin infections (HP:0005406)3.59084136
11Obstructive sleep apnea (HP:0002870)3.43685387
12Increased IgE level (HP:0003212)3.34845563
13Cellulitis (HP:0100658)3.33787833
14Myositis (HP:0100614)3.25904575
15Chronic obstructive pulmonary disease (HP:0006510)3.13150559
16Obstructive lung disease (HP:0006536)3.13150559
17Polycythemia (HP:0001901)3.11568542
18Spontaneous hematomas (HP:0007420)3.09505604
19Hyperlipoproteinemia (HP:0010980)3.09228038
20Recurrent gram-negative bacterial infections (HP:0005420)3.04351143
21Abnormality of the lower motor neuron (HP:0002366)2.97401277
22Mediastinal lymphadenopathy (HP:0100721)2.87694993
23Abnormality of monocarboxylic acid metabolism (HP:0010996)2.84381934
24Hyperammonemia (HP:0001987)2.83337057
25Meningitis (HP:0001287)2.81456865
26Hypobetalipoproteinemia (HP:0003563)2.80035278
27Elevated erythrocyte sedimentation rate (HP:0003565)2.79616836
28Gingivitis (HP:0000230)2.75590689
29Orchitis (HP:0100796)2.73393487
30Supranuclear gaze palsy (HP:0000605)2.72584692
31Recurrent fungal infections (HP:0002841)2.71515443
32Gastrointestinal infarctions (HP:0005244)2.69170344
33Prolonged bleeding time (HP:0003010)2.68367677
34Dysostosis multiplex (HP:0000943)2.62962977
35Colitis (HP:0002583)2.61283324
36Pustule (HP:0200039)2.60940759
37Gastrointestinal inflammation (HP:0004386)2.58824945
38Ketosis (HP:0001946)2.58499195
39Gout (HP:0001997)2.58196662
40Abnormal delayed hypersensitivity skin test (HP:0002963)2.50610581
41Gastrointestinal stroma tumor (HP:0100723)2.49268172
42Cerebral aneurysm (HP:0004944)2.44654951
43Insomnia (HP:0100785)2.44370409
44Inflammation of the large intestine (HP:0002037)2.43877330
45Intrahepatic cholestasis (HP:0001406)2.43720596
46Difficulty climbing stairs (HP:0003551)2.41241074
47Purpura (HP:0000979)2.40646658
48Myoglobinuria (HP:0002913)2.35571809
49Distal upper limb amyotrophy (HP:0007149)2.34999851
50Upper limb amyotrophy (HP:0009129)2.34999851
51Ankle clonus (HP:0011448)2.34385716
52Broad face (HP:0000283)2.33129409
53Emphysema (HP:0002097)2.32941857
54Delayed CNS myelination (HP:0002188)2.31983677
55Visual hallucinations (HP:0002367)2.30299829
56Annular pancreas (HP:0001734)2.29202532
57Vasculitis (HP:0002633)2.28522718
58Multiple enchondromatosis (HP:0005701)2.27742129
59Neonatal onset (HP:0003623)2.26678530
60Increased cerebral lipofuscin (HP:0011813)2.26665859
61Recurrent viral infections (HP:0004429)2.26244188
62Spastic diplegia (HP:0001264)2.25023221
63Malnutrition (HP:0004395)2.24975277
64Recurrent skin infections (HP:0001581)2.24706732
65Cerebral inclusion bodies (HP:0100314)2.24700067
66Global brain atrophy (HP:0002283)2.24421804
67Thin bony cortex (HP:0002753)2.23852905
68Hyperglycinuria (HP:0003108)2.23762003
69Agammaglobulinemia (HP:0004432)2.23666604
70Abnormality of the fingertips (HP:0001211)2.21032839
71Abnormal gallbladder physiology (HP:0012438)2.20692874
72Cholecystitis (HP:0001082)2.20692874
73Epistaxis (HP:0000421)2.20182978
74Retrobulbar optic neuritis (HP:0100654)2.20048461
75Optic neuritis (HP:0100653)2.20048461
76Hypolipoproteinemia (HP:0010981)2.18922726
77Abnormality of liposaccharide metabolism (HP:0010968)2.18586742
78Abnormality of glycosphingolipid metabolism (HP:0004343)2.18586742
79Abnormality of glycolipid metabolism (HP:0010969)2.18586742
80Ragged-red muscle fibers (HP:0003200)2.17327572
81Craniofacial dystonia (HP:0012179)2.17224577
82Abnormality of serine family amino acid metabolism (HP:0010894)2.15386702
83Abnormality of glycine metabolism (HP:0010895)2.15386702
84Torticollis (HP:0000473)2.14470887
85Reticulocytosis (HP:0001923)2.13760727
86Adenoma sebaceum (HP:0009720)2.13484427
87Angiofibromas (HP:0010615)2.13484427
88Abnormality of glutamine family amino acid metabolism (HP:0010902)2.12337165
89Hypertensive crisis (HP:0100735)2.11550986
90Focal dystonia (HP:0004373)2.11260598
91Panhypogammaglobulinemia (HP:0003139)2.10320943
92Encephalitis (HP:0002383)2.08647202
93Slow saccadic eye movements (HP:0000514)2.08448451
94Deep palmar crease (HP:0006191)2.06163282
95Ileus (HP:0002595)2.05354448
96Systemic lupus erythematosus (HP:0002725)2.05184861
97Stomatitis (HP:0010280)2.03867390
98Neuronal loss in central nervous system (HP:0002529)2.02053642
99Abnormality of cells of the erythroid lineage (HP:0012130)2.01965370
100Progressive muscle weakness (HP:0003323)2.01818405
101Hemorrhage of the eye (HP:0011885)2.01630916
102Hypoalphalipoproteinemia (HP:0003233)2.00864599
103Easy fatigability (HP:0003388)2.00817459
104Chest pain (HP:0100749)1.99334329
105Spastic tetraparesis (HP:0001285)1.98251591
106Protrusio acetabuli (HP:0003179)1.97710354
107Urticaria (HP:0001025)1.97303228
108Segmental peripheral demyelination/remyelination (HP:0003481)1.96702436
109Neurofibrillary tangles (HP:0002185)1.96662818
110Axonal loss (HP:0003447)1.95937123
111Increased variability in muscle fiber diameter (HP:0003557)1.95861502
112Hand muscle atrophy (HP:0009130)1.95594574
113Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.94058178
114Late onset (HP:0003584)1.94029507
115Delusions (HP:0000746)1.93229083
116Hyperglycinemia (HP:0002154)1.93177934
117Hypochromic anemia (HP:0001931)1.93136795
118Hyperacusis (HP:0010780)1.92934179
119Increased connective tissue (HP:0009025)1.92303394
120Centrally nucleated skeletal muscle fibers (HP:0003687)1.92067162
121Ketoacidosis (HP:0001993)1.90549536
122Lymphopenia (HP:0001888)1.90531198
123Papilledema (HP:0001085)1.90385232
124Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.90124464
125Increased neuronal autofluorescent lipopigment (HP:0002074)1.89861000
126Restrictive lung disease (HP:0002091)1.89824784
127Mucopolysacchariduria (HP:0008155)1.89647845
128Urinary glycosaminoglycan excretion (HP:0003541)1.89647845
129Hypertriglyceridemia (HP:0002155)1.89529933
130Petechiae (HP:0000967)1.89336020
131Increased serum ferritin (HP:0003281)1.89275403
132Lymphangioma (HP:0100764)1.88976648
133Distal lower limb amyotrophy (HP:0008944)1.88322679
134Abnormality of polysaccharide metabolism (HP:0011012)1.87996669
135Abnormality of glycosaminoglycan metabolism (HP:0004371)1.87996669
136Abnormality of mucopolysaccharide metabolism (HP:0011020)1.87996669
137Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.87989632
138Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.87285609
139Amyotrophic lateral sclerosis (HP:0007354)1.86907488
140Cholelithiasis (HP:0001081)1.86209838
141Increased IgM level (HP:0003496)1.86075373
142Abnormality of cells of the lymphoid lineage (HP:0012140)1.85688079
143Status epilepticus (HP:0002133)1.84960980
144Abnormality of the nasal mucosa (HP:0000433)1.84575099
145Hypergammaglobulinemia (HP:0010702)1.83973129
146Granulocytopenia (HP:0001913)1.83589225
147Abnormality of fatty-acid metabolism (HP:0004359)1.82906620
148Hyperbilirubinemia (HP:0002904)1.82809882
149Abnormality of dicarboxylic acid metabolism (HP:0010995)1.82752054
150Dicarboxylic aciduria (HP:0003215)1.82752054
151Pulmonary infiltrates (HP:0002113)1.82718732
152Genu recurvatum (HP:0002816)1.82404710
153Disproportionate tall stature (HP:0001519)1.82240501
154Hypercortisolism (HP:0001578)1.81558101
155Postural instability (HP:0002172)1.81402417
156Amyloidosis (HP:0011034)1.81374861
157Impaired social interactions (HP:0000735)1.81361167
158Abnormal social behavior (HP:0012433)1.81361167
159Ventricular fibrillation (HP:0001663)1.81312753
160Seborrheic dermatitis (HP:0001051)1.81011473
161Abnormal cartilage morphology (HP:0002763)1.80913485
162Interstitial pulmonary disease (HP:0006530)1.80811048
163Urinary urgency (HP:0000012)1.80472936
164Stridor (HP:0010307)1.80178533
165Acanthocytosis (HP:0001927)1.80038369
166Abnormality of binocular vision (HP:0011514)1.79790384
167Diplopia (HP:0000651)1.79790384
168Depression (HP:0000716)1.79588797
169Generalized hyperpigmentation (HP:0007440)1.79117381
170Loss of speech (HP:0002371)1.79045436
171Osteomyelitis (HP:0002754)1.79020162
172Hemiplegia (HP:0002301)1.76751332
173Sensorimotor neuropathy (HP:0007141)1.76737752
174Rapidly progressive (HP:0003678)1.76592788
175Verrucae (HP:0200043)1.76457752
176Papilloma (HP:0012740)1.76457752
177Athetosis (HP:0002305)1.74604638
178Irritability (HP:0000737)1.74252154
179Abnormality of sulfur amino acid metabolism (HP:0004339)1.73891319
180Muscle stiffness (HP:0003552)1.72774223
181Intention tremor (HP:0002080)1.72101456
182Abnormal number of erythroid precursors (HP:0012131)1.71995484
183Myopathic facies (HP:0002058)1.71211342
184Difficulty running (HP:0009046)1.70782160
185Gastrointestinal dysmotility (HP:0002579)1.70418792
186Polygenic inheritance (HP:0010982)1.70067008
187Epidermoid cyst (HP:0200040)1.69383407
188Nasal polyposis (HP:0100582)1.68233401
189Exercise-induced myalgia (HP:0003738)1.67645922

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.81426604
2PRPF4B3.79047980
3PKN23.73438328
4MAP3K103.11846049
5RIPK42.81657396
6ERN12.60389283
7SCYL22.29279745
8PRKD32.27543375
9TAOK12.26496409
10EEF2K2.24838677
11KSR22.16346722
12MAP3K132.14430254
13MAP3K112.12901304
14MAP3K92.05104645
15BCKDK2.03176827
16ICK2.02813471
17SMG11.97371694
18KDR1.87378207
19GRK61.83136154
20TYK21.81837546
21TNK21.79374727
22FES1.75486135
23IRAK41.66295952
24TESK21.66087768
25ARAF1.65901757
26MAP4K11.65545099
27DAPK21.65162693
28CAMKK11.64293269
29BLK1.57381828
30CSK1.56325535
31RIPK11.55489561
32PAK61.51814425
33LRRK21.50680587
34TESK11.50553998
35NME21.48626110
36EPHB11.42124780
37MAP2K21.40185491
38MAP3K71.37345954
39BTK1.31621463
40TYRO31.27272614
41TAOK21.24465114
42MAP3K31.23878816
43IRAK31.23600536
44ILK1.17819924
45JAK31.17052310
46EPHA41.14529890
47CDC42BPA1.14336073
48PTK61.13319627
49CDK191.12900346
50MAP3K141.08929223
51DAPK31.08203069
52NTRK11.07183903
53HCK1.05832219
54RAF11.02153339
55CDK121.02149727
56JAK11.00065308
57MINK10.98496610
58PDPK10.95801119
59PDK10.95161577
60SYK0.94808169
61DAPK10.93723453
62SIK30.92633636
63ITK0.91487760
64NEK10.90997209
65BMX0.90583601
66MAP2K30.89783904
67MAP3K10.88117250
68DYRK1B0.87311147
69LATS20.83875209
70PDK40.83352602
71PDK30.83352602
72RET0.83321670
73ALK0.82961876
74LCK0.82921209
75MAP3K80.81753071
76PINK10.81697698
77PAK40.80036012
78HIPK20.79297901
79SIK10.79082297
80RPS6KA20.75547792
81RPS6KC10.74850839
82RPS6KL10.74850839
83TXK0.74039024
84MAP3K60.73043921
85IKBKE0.72688595
86MARK30.71420099
87FGR0.70245022
88PRKCH0.69056814
89MAPK70.67813454
90MAP3K20.64976821
91PIM20.64572982
92MAP2K10.64431350
93LYN0.63432970
94JAK20.62795755
95STK110.62536029
96TGFBR20.62197176
97IRAK20.62109935
98MAP2K40.62092045
99CDK150.62059755
100CDK140.61926173
101MAPK110.61192347
102CDK11A0.60444743
103NEK20.59880568
104MAPK120.58049896
105RPS6KA60.58022987
106UHMK10.57774650
107KIT0.57384824
108IKBKB0.57129027
109CDK50.56441594
110PTK2B0.56248961
111BRAF0.55675673
112DYRK30.55462835
113STK380.55289309
114CDK40.53809351
115MAP2K60.53064432
116LMTK20.53039414
117PDGFRA0.52748040
118SGK30.52649582
119PRKG20.52440171
120CSF1R0.52262606
121CDK180.51645835
122PRKD10.50385642
123PAK10.49934822
124MARK20.49921821
125FYN0.49772599
126TBK10.49564153
127FGFR40.49194039
128FGFR30.48891260
129TIE10.46761976
130SIK20.46339439
131PHKG10.45596774
132PHKG20.45596774
133MAPKAPK30.45141719
134MTOR0.43263696
135MAPK40.43121149
136TTN0.43070233
137CAMK10.41050543
138ABL20.40748779
139PTK20.40742181
140STK100.40555871
141ZAP700.39194213
142PRKD20.39005485
143MOS0.38642534
144PRKCZ0.37940367
145PAK20.37634095
146BRSK10.36459209
147CSNK1G20.36128117
148NME10.36121230
149KSR10.35155373
150MATK0.34732735

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009104.56931235
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.04259693
3Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.67940237
4Arginine biosynthesis_Homo sapiens_hsa002202.65568360
5Primary bile acid biosynthesis_Homo sapiens_hsa001202.62590313
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.54877035
72-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.47495124
8Sulfur relay system_Homo sapiens_hsa041222.45769293
9Osteoclast differentiation_Homo sapiens_hsa043802.26531012
10Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.24889724
11Other glycan degradation_Homo sapiens_hsa005112.20144691
12Leishmaniasis_Homo sapiens_hsa051402.02250710
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.96730747
14Acute myeloid leukemia_Homo sapiens_hsa052211.94591506
15Fatty acid degradation_Homo sapiens_hsa000711.92057145
16Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.89747089
17Bile secretion_Homo sapiens_hsa049761.89345105
18Cyanoamino acid metabolism_Homo sapiens_hsa004601.82179437
19Graft-versus-host disease_Homo sapiens_hsa053321.81761077
20Biosynthesis of amino acids_Homo sapiens_hsa012301.77575094
21Butanoate metabolism_Homo sapiens_hsa006501.71845158
22Pyruvate metabolism_Homo sapiens_hsa006201.71612955
23Carbon metabolism_Homo sapiens_hsa012001.71551629
24Allograft rejection_Homo sapiens_hsa053301.71171352
25Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.70306484
26Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.69602629
27Fat digestion and absorption_Homo sapiens_hsa049751.67086375
28T cell receptor signaling pathway_Homo sapiens_hsa046601.64581593
29Primary immunodeficiency_Homo sapiens_hsa053401.63823773
30Staphylococcus aureus infection_Homo sapiens_hsa051501.63244431
31Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.62504139
32Toll-like receptor signaling pathway_Homo sapiens_hsa046201.59805443
33Autoimmune thyroid disease_Homo sapiens_hsa053201.59269101
34Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.57918533
35Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.51963423
36Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.48955812
37Chronic myeloid leukemia_Homo sapiens_hsa052201.44611871
38PPAR signaling pathway_Homo sapiens_hsa033201.44229699
39Tuberculosis_Homo sapiens_hsa051521.41214642
40Propanoate metabolism_Homo sapiens_hsa006401.40692330
41Fatty acid metabolism_Homo sapiens_hsa012121.39395988
42Notch signaling pathway_Homo sapiens_hsa043301.39362014
43Toxoplasmosis_Homo sapiens_hsa051451.33935315
44NF-kappa B signaling pathway_Homo sapiens_hsa040641.33608565
45Viral myocarditis_Homo sapiens_hsa054161.33508508
46Cysteine and methionine metabolism_Homo sapiens_hsa002701.31525679
47Pentose phosphate pathway_Homo sapiens_hsa000301.29402997
48Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.28992357
49Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.28509478
50Neurotrophin signaling pathway_Homo sapiens_hsa047221.26802441
51Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.25336535
52Chemokine signaling pathway_Homo sapiens_hsa040621.24498680
53Malaria_Homo sapiens_hsa051441.24364955
54Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.23409675
55Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.22049941
56Leukocyte transendothelial migration_Homo sapiens_hsa046701.22043512
57Pentose and glucuronate interconversions_Homo sapiens_hsa000401.20488901
58Pancreatic cancer_Homo sapiens_hsa052121.17981500
59TNF signaling pathway_Homo sapiens_hsa046681.17874026
60Tryptophan metabolism_Homo sapiens_hsa003801.17115499
61VEGF signaling pathway_Homo sapiens_hsa043701.16746731
62Drug metabolism - other enzymes_Homo sapiens_hsa009831.13401693
63Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.12248920
64Synaptic vesicle cycle_Homo sapiens_hsa047211.11471202
65Measles_Homo sapiens_hsa051621.09222515
66AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.09035249
67Influenza A_Homo sapiens_hsa051641.09004357
68Antigen processing and presentation_Homo sapiens_hsa046121.07118521
69Type I diabetes mellitus_Homo sapiens_hsa049401.06763367
70Glycosaminoglycan degradation_Homo sapiens_hsa005311.05402504
71RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.05176924
72Renal cell carcinoma_Homo sapiens_hsa052111.04573875
73Folate biosynthesis_Homo sapiens_hsa007901.04228398
74Phosphatidylinositol signaling system_Homo sapiens_hsa040701.03540530
75Selenocompound metabolism_Homo sapiens_hsa004501.02906125
76Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.02247991
77Platelet activation_Homo sapiens_hsa046111.02071267
78Prion diseases_Homo sapiens_hsa050201.00520975
79Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.98041985
80Sulfur metabolism_Homo sapiens_hsa009200.97979048
81Hematopoietic cell lineage_Homo sapiens_hsa046400.97092836
82Hepatitis B_Homo sapiens_hsa051610.96835668
83Choline metabolism in cancer_Homo sapiens_hsa052310.95329787
84Hepatitis C_Homo sapiens_hsa051600.95058768
85Olfactory transduction_Homo sapiens_hsa047400.95009342
86beta-Alanine metabolism_Homo sapiens_hsa004100.93864771
87Peroxisome_Homo sapiens_hsa041460.93571560
88Endometrial cancer_Homo sapiens_hsa052130.92271810
89Lysosome_Homo sapiens_hsa041420.92232706
90Intestinal immune network for IgA production_Homo sapiens_hsa046720.91364717
91Sphingolipid signaling pathway_Homo sapiens_hsa040710.91275124
92Apoptosis_Homo sapiens_hsa042100.90671754
93NOD-like receptor signaling pathway_Homo sapiens_hsa046210.90356945
94Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.89652060
95Glycerolipid metabolism_Homo sapiens_hsa005610.89378728
96Herpes simplex infection_Homo sapiens_hsa051680.89137922
97Pertussis_Homo sapiens_hsa051330.87752767
98Prolactin signaling pathway_Homo sapiens_hsa049170.86955385
99ErbB signaling pathway_Homo sapiens_hsa040120.83389437
100Jak-STAT signaling pathway_Homo sapiens_hsa046300.80683533
101Long-term potentiation_Homo sapiens_hsa047200.80530733
102Arginine and proline metabolism_Homo sapiens_hsa003300.78656025
103Bladder cancer_Homo sapiens_hsa052190.78517656
104Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.78405491
105Chemical carcinogenesis_Homo sapiens_hsa052040.78042584
106Inositol phosphate metabolism_Homo sapiens_hsa005620.77264010
107Phagosome_Homo sapiens_hsa041450.77227083
108Gastric acid secretion_Homo sapiens_hsa049710.76983521
109Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.76652503
110HTLV-I infection_Homo sapiens_hsa051660.76464989
111Complement and coagulation cascades_Homo sapiens_hsa046100.76218798
112Amoebiasis_Homo sapiens_hsa051460.75323373
113MAPK signaling pathway_Homo sapiens_hsa040100.74921617
114Salmonella infection_Homo sapiens_hsa051320.74906321
115Fatty acid biosynthesis_Homo sapiens_hsa000610.73712336
116Colorectal cancer_Homo sapiens_hsa052100.73242330
117Rap1 signaling pathway_Homo sapiens_hsa040150.72188141
118Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.72035731
119Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.71350185
120Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.70841641
121Glioma_Homo sapiens_hsa052140.70673866
122Shigellosis_Homo sapiens_hsa051310.70623835
123Central carbon metabolism in cancer_Homo sapiens_hsa052300.70095767
124Caffeine metabolism_Homo sapiens_hsa002320.69380351
125Ribosome_Homo sapiens_hsa030100.68471091
126Thyroid hormone signaling pathway_Homo sapiens_hsa049190.67103988
127African trypanosomiasis_Homo sapiens_hsa051430.66172196
128Fructose and mannose metabolism_Homo sapiens_hsa000510.65952279
129Non-small cell lung cancer_Homo sapiens_hsa052230.64670518
130Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.64582980
131Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.63564011
132Adipocytokine signaling pathway_Homo sapiens_hsa049200.63272743
133Galactose metabolism_Homo sapiens_hsa000520.62899994
134FoxO signaling pathway_Homo sapiens_hsa040680.62894041
135Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.62790355
136Rheumatoid arthritis_Homo sapiens_hsa053230.62612751
137Asthma_Homo sapiens_hsa053100.62337059
138Glucagon signaling pathway_Homo sapiens_hsa049220.61293365
139Glutathione metabolism_Homo sapiens_hsa004800.60500427
140Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.60070891
141Histidine metabolism_Homo sapiens_hsa003400.59040253
142Aldosterone synthesis and secretion_Homo sapiens_hsa049250.58489028
143HIF-1 signaling pathway_Homo sapiens_hsa040660.58253363
144Viral carcinogenesis_Homo sapiens_hsa052030.56884533
145Insulin signaling pathway_Homo sapiens_hsa049100.56746463
146Carbohydrate digestion and absorption_Homo sapiens_hsa049730.55375536
147Thyroid cancer_Homo sapiens_hsa052160.55131905
148AMPK signaling pathway_Homo sapiens_hsa041520.54596966
149Type II diabetes mellitus_Homo sapiens_hsa049300.53877937
150Ras signaling pathway_Homo sapiens_hsa040140.53733956
151Glycerophospholipid metabolism_Homo sapiens_hsa005640.53505510
152Estrogen signaling pathway_Homo sapiens_hsa049150.51374279
153Gap junction_Homo sapiens_hsa045400.51189726
154Starch and sucrose metabolism_Homo sapiens_hsa005000.51066031
155Salivary secretion_Homo sapiens_hsa049700.49757363
156mTOR signaling pathway_Homo sapiens_hsa041500.49740355
157Endocytosis_Homo sapiens_hsa041440.49096769
158Cardiac muscle contraction_Homo sapiens_hsa042600.47789965
159B cell receptor signaling pathway_Homo sapiens_hsa046620.47423759
160Longevity regulating pathway - mammal_Homo sapiens_hsa042110.47032885
161Dopaminergic synapse_Homo sapiens_hsa047280.46535660
162Insulin resistance_Homo sapiens_hsa049310.45142375
163Amphetamine addiction_Homo sapiens_hsa050310.43970195
164Parkinsons disease_Homo sapiens_hsa050120.43892062
165Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.43617012
166Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.39699936
167Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.38561050
168Pancreatic secretion_Homo sapiens_hsa049720.37963281
169Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.37795984
170Insulin secretion_Homo sapiens_hsa049110.37520551
171GnRH signaling pathway_Homo sapiens_hsa049120.37489402
172Oxytocin signaling pathway_Homo sapiens_hsa049210.35099191
173Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.34627064
174Cholinergic synapse_Homo sapiens_hsa047250.33879460
175GABAergic synapse_Homo sapiens_hsa047270.33580291
176Phospholipase D signaling pathway_Homo sapiens_hsa040720.33276060
177Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.32801361
178Circadian entrainment_Homo sapiens_hsa047130.31510631

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