ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	folic acid-containing compound biosynthetic process (GO:0009396)	9.70877964
2	sulfur amino acid catabolic process (GO:0000098)	8.90579545
3	cysteine metabolic process (GO:0006534)	8.32572481
4	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	7.76703974
5	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	7.76703974
6	microtubule nucleation (GO:0007020)	7.73906557
7	white fat cell differentiation (GO:0050872)	7.66574011
8	desmosome organization (GO:0002934)	7.54423174
9	epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)	7.34161022
10	purine nucleotide salvage (GO:0032261)	7.24219579
11	adenosine metabolic process (GO:0046085)	6.42455188
12	regulation of vitamin D biosynthetic process (GO:0060556)	6.42311757
13	alternative mRNA splicing, via spliceosome (GO:0000380)	6.21044651
14	cell migration involved in heart development (GO:0060973)	6.18744060
15	negative regulation of DNA biosynthetic process (GO:2000279)	6.13128346
16	pteridine-containing compound biosynthetic process (GO:0042559)	6.02574434
17	L-serine metabolic process (GO:0006563)	5.92881574
18	positive regulation of endothelial cell differentiation (GO:0045603)	5.63343083
19	regulation of branching involved in salivary gland morphogenesis (GO:0060693)	5.44439127
20	negative regulation of catenin import into nucleus (GO:0035414)	5.40759938
21	inner ear receptor cell development (GO:0060119)	5.36165151
22	galactose catabolic process (GO:0019388)	5.34012751
23	negative regulation of Ras GTPase activity (GO:0034261)	5.32373707
24	regulation of tight junction assembly (GO:2000810)	5.31181128
25	mitochondrial RNA metabolic process (GO:0000959)	5.25023857
26	negative regulation of keratinocyte proliferation (GO:0010839)	5.23750220
27	regulation of vitamin metabolic process (GO:0030656)	5.18903955
28	folic acid-containing compound metabolic process (GO:0006760)	5.04062759
29	tetrahydrofolate metabolic process (GO:0046653)	4.89564158
30	serine family amino acid biosynthetic process (GO:0009070)	4.87549769
31	histone H4-K12 acetylation (GO:0043983)	4.77546136
32	galactose metabolic process (GO:0006012)	4.76617054
33	regulation of gonadotropin secretion (GO:0032276)	4.75270894
34	IMP biosynthetic process (GO:0006188)	4.65073409
35	phosphatidylglycerol biosynthetic process (GO:0006655)	4.62459299
36	protein-chromophore linkage (GO:0018298)	4.56550711
37	cartilage morphogenesis (GO:0060536)	4.47480683
38	response to vitamin A (GO:0033189)	4.41893680
39	pathway-restricted SMAD protein phosphorylation (GO:0060389)	4.23760939
40	nucleotide salvage (GO:0043173)	4.23159160
41	regulation of sequestering of triglyceride (GO:0010889)	4.22009855
42	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	4.19144101
43	cochlea development (GO:0090102)	4.18040023
44	folic acid metabolic process (GO:0046655)	4.15066117
45	negative regulation of blood vessel endothelial cell migration (GO:0043537)	4.06241487
46	COPII vesicle coating (GO:0048208)	4.02022801
47	IMP metabolic process (GO:0046040)	3.96872261
48	folic acid transport (GO:0015884)	3.96435748
49	negative regulation of cell size (GO:0045792)	3.91823536
50	negative regulation of telomerase activity (GO:0051974)	3.91794945
51	negative regulation of alcohol biosynthetic process (GO:1902931)	3.90298067
52	regulation of cholesterol storage (GO:0010885)	3.88126923
53	pteridine-containing compound metabolic process (GO:0042558)	3.87571679
54	regulation of endothelial cell differentiation (GO:0045601)	3.81803807
55	primary amino compound metabolic process (GO:1901160)	3.81456116
56	response to lipoprotein particle (GO:0055094)	3.75986933
57	sulfur amino acid biosynthetic process (GO:0000097)	3.73975373
58	negative regulation of anoikis (GO:2000811)	3.73314854
59	serine family amino acid catabolic process (GO:0009071)	3.68896862
60	negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)	3.63775619
61	innervation (GO:0060384)	3.63156044
62	nucleoside transmembrane transport (GO:1901642)	3.59107795
63	polyamine biosynthetic process (GO:0006596)	3.57776404
64	energy homeostasis (GO:0097009)	3.51683874
65	one-carbon metabolic process (GO:0006730)	3.49569248
66	aminoglycoside antibiotic metabolic process (GO:0030647)	3.49073778
67	negative regulation of chondrocyte differentiation (GO:0032331)	3.46970225
68	rRNA methylation (GO:0031167)	3.44720317
69	organic cation transport (GO:0015695)	3.42995595
70	tRNA modification (GO:0006400)	3.40684972
71	sulfur amino acid metabolic process (GO:0000096)	3.39564972
72	peptidyl-proline hydroxylation (GO:0019511)	3.37640516
73	4-hydroxyproline metabolic process (GO:0019471)	3.33490954
74	regulation of DNA biosynthetic process (GO:2000278)	3.33310947
75	positive regulation of fatty acid metabolic process (GO:0045923)	3.31228058
76	negative regulation of stem cell proliferation (GO:2000647)	3.30992960
77	glycoside metabolic process (GO:0016137)	3.29448652
78	glycosphingolipid catabolic process (GO:0046479)	3.27778407
79	acrosome assembly (GO:0001675)	3.20944103
80	cellular protein complex localization (GO:0034629)	3.17287643
81	behavioral fear response (GO:0001662)	3.16592312
82	behavioral defense response (GO:0002209)	3.16592312
83	positive regulation of histone acetylation (GO:0035066)	3.15481596
84	neural crest cell development (GO:0014032)	3.14967449
85	muscle atrophy (GO:0014889)	3.13697739
86	alpha-amino acid biosynthetic process (GO:1901607)	3.13254933
87	negative regulation of interleukin-1 beta production (GO:0032691)	3.12902938
88	growth hormone secretion (GO:0030252)	3.12452807
89	cardiac epithelial to mesenchymal transition (GO:0060317)	3.10681143
90	cilium or flagellum-dependent cell motility (GO:0001539)	3.00397393
91	regulation of anoikis (GO:2000209)	2.97134174
92	response to parathyroid hormone (GO:0071107)	2.93732862
93	response to mercury ion (GO:0046689)	2.91345160
94	chromosome condensation (GO:0030261)	2.90917159
95	hepatocyte apoptotic process (GO:0097284)	2.90784064
96	purine-containing compound salvage (GO:0043101)	2.90718727
97	glycolipid catabolic process (GO:0019377)	2.90537575
98	cellular modified amino acid catabolic process (GO:0042219)	2.86645723
99	homocysteine metabolic process (GO:0050667)	10.8433472
100	regulation of plasminogen activation (GO:0010755)	10.7463973

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	5.02901797
2	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	4.06304171
3	E2F7_22180533_ChIP-Seq_HELA_Human	3.57816974
4	IRF8_22096565_ChIP-ChIP_GC-B_Human	3.07728747
5	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	2.78842503
6	MYC_22102868_ChIP-Seq_BL_Human	2.71243633
7	LXR_22292898_ChIP-Seq_THP-1_Human	2.36926633
8	TP63_17297297_ChIP-ChIP_HaCaT_Human	2.28071100
9	STAT6_21828071_ChIP-Seq_BEAS2B_Human	2.14756958
10	VDR_21846776_ChIP-Seq_THP-1_Human	2.04617011
11	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	10.3854705
12	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.78714195
13	RXR_22158963_ChIP-Seq_LIVER_Mouse	1.77572956
14	STAT3_19079543_ChIP-ChIP_MESCs_Mouse	1.75689687
15	P68_20966046_ChIP-Seq_HELA_Human	1.73946061
16	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.69891574
17	ZNF263_19887448_ChIP-Seq_K562_Human	1.64123858
18	ELK3_25401928_ChIP-Seq_HUVEC_Human	1.63080538
19	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.60448791
20	E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human	1.58688489
21	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.49710080
22	TP53_22127205_ChIP-Seq_IMR90_Human	1.48335112
23	NCOR1_26117541_ChIP-Seq_K562_Human	1.47866584
24	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	1.46704444
25	PPARA_22158963_ChIP-Seq_LIVER_Mouse	1.45446482
26	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.38515448
27	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.37971696
28	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	1.36608295
29	TCF7_22412390_ChIP-Seq_EML_Mouse	1.34775986
30	STAT1_20625510_ChIP-Seq_HELA_Human	1.34673637
31	KDM2B_26808549_Chip-Seq_SUP-B15_Human	1.34398861
32	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	1.34316646
33	ETS1_21867929_ChIP-Seq_TH2_Mouse	1.33910395
34	TBX5_21415370_ChIP-Seq_HL-1_Mouse	1.33757799
35	RACK7_27058665_Chip-Seq_MCF-7_Human	1.33522412
36	NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse	1.33250891
37	AR_21909140_ChIP-Seq_LNCAP_Human	1.32857453
38	MAF_26560356_Chip-Seq_TH2_Human	1.32586195
39	GATA1_22383799_ChIP-Seq_G1ME_Mouse	1.31720523
40	KDM2B_26808549_Chip-Seq_SIL-ALL_Human	1.30230984
41	TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.28814740
42	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.28122152
43	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.28056150
44	CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse	1.27762483
45	CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.26777855
46	GATA3_20176728_ChIP-ChIP_TSCs_Mouse	1.26409968
47	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	1.25393223
48	BRD4_27068464_Chip-Seq_AML-cells_Mouse	1.24387986
49	MEIS1_20887958_ChIP-Seq_HPC-7_Mouse	1.24020948
50	PU.1_20513432_ChIP-Seq_Bcells_Mouse	1.20497363
51	FLI1_21867929_ChIP-Seq_CD8_Mouse	1.19879909
52	BCOR_27268052_Chip-Seq_Bcells_Human	1.19502261
53	VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human	1.19311374
54	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.19144758
55	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	1.18098738
56	KLF4_18555785_ChIP-Seq_MESCs_Mouse	1.17571509
57	SMAD1_18555785_ChIP-Seq_MESCs_Mouse	1.15236416
58	MECOM_23826213_ChIP-Seq_KASUMI_Mouse	1.11759415
59	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.10654830
60	CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse	1.10053132
61	RXRA_24833708_ChIP-Seq_LIVER_Mouse	1.09411243
62	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.09265694
63	SOX2_22085726_ChIP-Seq_NPCs_Mouse	1.08607852
64	PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse	1.08515692
65	ATF3_27146783_Chip-Seq_COLON_Human	1.08099073
66	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.05709137
67	UTX_26944678_Chip-Seq_JUKART_Human	1.02583173
68	EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human	1.02441776
69	UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human	1.00993913
70	RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	1.00712574
71	CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse	0.99741356
72	SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.99046262
73	TET1_21451524_ChIP-Seq_MESCs_Mouse	0.96282967
74	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	0.95734270
75	TP63_22573176_ChIP-Seq_HFKS_Human	0.94768296
76	CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse	0.93795515
77	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.92675365
78	KDM2B_26808549_Chip-Seq_JURKAT_Human	0.92239245
79	SMC4_20622854_ChIP-Seq_HELA_Human	0.91824280
80	CREB1_26743006_Chip-Seq_LNCaP-abl_Human	0.90784140
81	NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse	0.90286399
82	MYB_21317192_ChIP-Seq_ERMYB_Mouse	0.89758823
83	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	0.89618275
84	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	0.88813771
85	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	0.88293534
86	GATA2_22383799_ChIP-Seq_G1ME_Mouse	0.87767859
87	MYC_19079543_ChIP-ChIP_MESCs_Mouse	0.87565473
88	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	0.85455659
89	DNAJC2_21179169_ChIP-ChIP_NT2_Human	0.85117592
90	PKCTHETA_26484144_Chip-Seq_BREAST_Human	0.84879844
91	CTNNB1_20460455_ChIP-Seq_HCT116_Human	0.84765579
92	ERG_21242973_ChIP-ChIP_JURKAT_Human	0.84146794
93	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	0.83647462
94	CTCF_21964334_ChIP-Seq_BJAB-B_Human	0.82590748
95	MAF_26560356_Chip-Seq_TH1_Human	0.82457521
96	ZFP281_18358816_ChIP-ChIP_MESCs_Mouse	0.82183320
97	RUNX2_24764292_ChIP-Seq_MC3T3_Mouse	0.82024025
98	JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse	0.81657163
99	SRY_22984422_ChIP-ChIP_TESTIS_Rat	0.81564554
100	MYC_27129775_Chip-Seq_CORNEA_Mouse	0.81292053

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003705_abnormal_hypodermis_morpholog	7.27926098
2	MP0005360_urolithiasis	6.75823456
3	MP0005670_abnormal_white_adipose	5.33504319
4	MP0003183_abnormal_peptide_metabolism	4.32748908
5	MP0000013_abnormal_adipose_tissue	4.01328417
6	MP0005646_abnormal_pituitary_gland	3.97697157
7	MP0001661_extended_life_span	3.76907774
8	MP0002396_abnormal_hematopoietic_system	3.60092383
9	MP0008995_early_reproductive_senescence	3.34641244
10	MP0004185_abnormal_adipocyte_glucose	3.02434223
11	MP0003724_increased_susceptibility_to	2.83990522
12	MP0000003_abnormal_adipose_tissue	2.25464757
13	MP0004885_abnormal_endolymph	2.08827732
14	MP0002938_white_spotting	1.96582675
15	MP0002132_abnormal_respiratory_system	1.89762728
16	MP0000516_abnormal_urinary_system	1.88005938
17	MP0005367_renal/urinary_system_phenotyp	1.88005938
18	MP0003806_abnormal_nucleotide_metabolis	1.82204200
19	MP0002138_abnormal_hepatobiliary_system	1.75636429
20	MP0005332_abnormal_amino_acid	1.75494784
21	MP0005076_abnormal_cell_differentiation	1.75327909
22	MP0001851_eye_inflammation	1.72266345
23	MP0002139_abnormal_hepatobiliary_system	1.66023806
24	MP0002736_abnormal_nociception_after	1.62123819
25	MP0004147_increased_porphyrin_level	1.55341891
26	MP0004130_abnormal_muscle_cell	1.52609371
27	MP0000534_abnormal_ureter_morphology	1.45760080
28	MP0000371_diluted_coat_color	1.32569828
29	MP0000566_synostosis	1.27533710
30	MP0001764_abnormal_homeostasis	1.25909999
31	MP0003186_abnormal_redox_activity	1.23654939
32	MP0002095_abnormal_skin_pigmentation	1.22826309
33	MP0004233_abnormal_muscle_weight	1.14212399
34	MP0004043_abnormal_pH_regulation	1.12795233
35	MP0005164_abnormal_response_to	1.12527175
36	MP0003045_fibrosis	1.05561724
37	MP0005085_abnormal_gallbladder_physiolo	1.00709637
38	MP0003436_decreased_susceptibility_to	1.00358572
39	MP0000678_abnormal_parathyroid_gland	1.00137134
40	MP0008872_abnormal_physiological_respon	0.99100454
41	MP0009643_abnormal_urine_homeostasis	0.98071250
42	MP0009115_abnormal_fat_cell	0.97120817
43	MP0001533_abnormal_skeleton_physiology	0.95274729
44	MP0000762_abnormal_tongue_morphology	0.95019789
45	MP0000747_muscle_weakness	0.90340129
46	MP0003786_premature_aging	0.88898036
47	MP0004947_skin_inflammation	0.84660914
48	MP0009333_abnormal_splenocyte_physiolog	0.84582132
49	MP0003942_abnormal_urinary_system	0.84242014
50	MP0001944_abnormal_pancreas_morphology	0.79434516
51	MP0000647_abnormal_sebaceous_gland	0.78195271
52	MP0001849_ear_inflammation	0.77475422
53	MP0001270_distended_abdomen	0.77158706
54	MP0001340_abnormal_eyelid_morphology	0.76445046
55	MP0001756_abnormal_urination	0.76023957
56	MP0000750_abnormal_muscle_regeneration	0.75525616
57	MP0005666_abnormal_adipose_tissue	0.74469102
58	MP0005376_homeostasis/metabolism_phenot	0.73570683
59	MP0001800_abnormal_humoral_immune	0.73162175
60	MP0002060_abnormal_skin_morphology	0.72262894
61	MP0002295_abnormal_pulmonary_circulatio	0.71850961
62	MP0002971_abnormal_brown_adipose	0.71514205
63	MP0002009_preneoplasia	0.70841411
64	MP0005375_adipose_tissue_phenotype	0.70570442
65	MP0001216_abnormal_epidermal_layer	0.69052378
66	MP0000026_abnormal_inner_ear	0.69016729
67	MP0009697_abnormal_copulation	0.68346871
68	MP0005334_abnormal_fat_pad	0.68309683
69	MP0005000_abnormal_immune_tolerance	0.67510213
70	MP0000703_abnormal_thymus_morphology	0.64134510
71	MP0002006_tumorigenesis	0.63808662
72	MP0000733_abnormal_muscle_development	0.60094762
73	MP0002069_abnormal_eating/drinking_beha	0.59246474
74	MP0002735_abnormal_chemical_nociception	0.59242920
75	MP0000858_altered_metastatic_potential	0.58574995
76	MP0001968_abnormal_touch/_nociception	0.56928117
77	MP0002075_abnormal_coat/hair_pigmentati	0.55711183
78	MP0002933_joint_inflammation	0.55118193
79	MP0002078_abnormal_glucose_homeostasis	0.55060062
80	MP0005319_abnormal_enzyme/_coenzyme	0.53362353
81	MP0002419_abnormal_innate_immunity	0.53315768
82	MP0002970_abnormal_white_adipose	0.52631362
83	MP0001502_abnormal_circadian_rhythm	0.52497517
84	MP0005365_abnormal_bile_salt	0.52273466
85	MP0002108_abnormal_muscle_morphology	0.51640285
86	MP0003252_abnormal_bile_duct	0.51628917
87	MP0000598_abnormal_liver_morphology	0.50116759
88	MP0005083_abnormal_biliary_tract	0.49863558
89	MP0005595_abnormal_vascular_smooth	0.49123827
90	MP0004133_heterotaxia	0.47334899
91	MP0002269_muscular_atrophy	0.47307087
92	MP0001243_abnormal_dermal_layer	0.46455983
93	MP0003315_abnormal_perineum_morphology	0.46311684
94	MP0002452_abnormal_antigen_presenting	0.45955070
95	MP0002723_abnormal_immune_serum	0.45059361
96	MP0003115_abnormal_respiratory_system	0.44217285
97	MP0000249_abnormal_blood_vessel	0.43728271
98	MP0004134_abnormal_chest_morphology	0.43516244
99	MP0009931_abnormal_skin_appearance	0.43461475
100	MP0003638_abnormal_response/metabolism_	0.42088923

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	8.99969259
2	Abnormality of alanine metabolism (HP:0010916)	8.99969259
3	Hyperalaninemia (HP:0003348)	8.99969259
4	Spontaneous hematomas (HP:0007420)	7.10195914
5	Constricted visual fields (HP:0001133)	6.47530589
6	Esophageal varix (HP:0002040)	6.10976697
7	Congenital sensorineural hearing impairment (HP:0008527)	5.44431608
8	Abnormality of the fetal cardiovascular system (HP:0010948)	5.23728332
9	Abnormal umbilical cord blood vessels (HP:0011403)	5.23728332
10	Single umbilical artery (HP:0001195)	5.23728332
11	Myocardial infarction (HP:0001658)	4.89476070
12	White forelock (HP:0002211)	4.83727581
13	Abnormality of homocysteine metabolism (HP:0010919)	4.38633898
14	Homocystinuria (HP:0002156)	4.38633898
15	Patchy hypopigmentation of hair (HP:0011365)	4.16210595
16	Anorexia (HP:0002039)	4.10294714
17	Conjunctival telangiectasia (HP:0000524)	4.08264673
18	Hypoalphalipoproteinemia (HP:0003233)	4.00614359
19	Birth length less than 3rd percentile (HP:0003561)	3.76050837
20	Conjugated hyperbilirubinemia (HP:0002908)	3.64497893
21	Decreased electroretinogram (ERG) amplitude (HP:0000654)	3.57766806
22	Pulmonary embolism (HP:0002204)	3.56500566
23	Abnormality of the umbilical cord (HP:0010881)	3.52600491
24	Visceral angiomatosis (HP:0100761)	3.51574577
25	Action tremor (HP:0002345)	3.46924817
26	Fatigue (HP:0012378)	3.44204017
27	Biconcave vertebral bodies (HP:0004586)	3.35697773
28	Abnormality of the vasculature of the conjunctiva (HP:0008054)	3.31625333
29	Heterochromia iridis (HP:0001100)	3.31155965
30	Chronic otitis media (HP:0000389)	3.28386412
31	Hemangiomatosis (HP:0007461)	3.21553795
32	Abnormality of serum amino acid levels (HP:0003112)	3.17764944
33	Abnormality of sulfur amino acid metabolism (HP:0004339)	3.06510936
34	Poor speech (HP:0002465)	2.96889756
35	Myopathic facies (HP:0002058)	2.88396300
36	Reduced subcutaneous adipose tissue (HP:0003758)	2.84673919
37	Oligomenorrhea (HP:0000876)	2.81956881
38	Thrombophlebitis (HP:0004418)	2.74829037
39	Toxemia of pregnancy (HP:0100603)	2.67594734
40	Hypopigmentation of the fundus (HP:0007894)	2.57312610
41	Disproportionate tall stature (HP:0001519)	2.50766763
42	Ileus (HP:0002595)	2.49422782
43	Polygenic inheritance (HP:0010982)	2.48574589
44	Pigmentary retinal degeneration (HP:0001146)	2.46511709
45	Decreased subcutaneous fat (HP:0001002)	2.44531745
46	Generalized aminoaciduria (HP:0002909)	2.39444503
47	Gingival bleeding (HP:0000225)	2.29059564
48	Cone-rod dystrophy (HP:0000548)	2.28129841
49	Arterial thrombosis (HP:0004420)	2.25392694
50	Elevated erythrocyte sedimentation rate (HP:0003565)	2.22557474
51	Cortical visual impairment (HP:0100704)	2.19505500
52	Arteriovenous malformation (HP:0100026)	2.19196161
53	Abnormality of the phalanges of the hallux (HP:0010057)	2.17946484
54	Insulin-resistant diabetes mellitus (HP:0000831)	2.16670164
55	Peritonitis (HP:0002586)	2.15643327
56	Maternal diabetes (HP:0009800)	2.14184013
57	Cavernous hemangioma (HP:0001048)	2.13540127
58	Elevated alkaline phosphatase (HP:0003155)	2.09236544
59	Abnormalities of placenta or umbilical cord (HP:0001194)	2.08053489
60	Hypolipoproteinemia (HP:0010981)	2.02746337
61	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	2.01678177
62	Complete atrioventricular canal defect (HP:0001674)	2.01219026
63	Chorioretinal atrophy (HP:0000533)	1.98352143
64	Epidermoid cyst (HP:0200040)	1.96535738
65	Hyperuricemia (HP:0002149)	1.95490738
66	Increased purine levels (HP:0004368)	1.95490738
67	Duplicated collecting system (HP:0000081)	1.94441553
68	Chronic hepatic failure (HP:0100626)	1.93338562
69	Flat acetabular roof (HP:0003180)	1.91811551
70	Abnormality of pyrimidine metabolism (HP:0004353)	1.91802879
71	Abnormality of alkaline phosphatase activity (HP:0004379)	1.91207454
72	Recurrent abscess formation (HP:0002722)	1.90361391
73	Diaphragmatic weakness (HP:0009113)	1.86913797
74	Hypoplastic left heart (HP:0004383)	1.86861718
75	Attenuation of retinal blood vessels (HP:0007843)	1.85156172
76	Abnormal enzyme/coenzyme activity (HP:0012379)	1.84952619
77	Abnormality of the fingertips (HP:0001211)	1.82980133
78	Nausea (HP:0002018)	1.81472093
79	Abnormality of the renal collecting system (HP:0004742)	1.81386186
80	Hemoptysis (HP:0002105)	1.78930949
81	Microcytic anemia (HP:0001935)	1.78771797
82	Hypergammaglobulinemia (HP:0010702)	1.77877976
83	Pustule (HP:0200039)	1.77578434
84	Chromosomal breakage induced by crosslinking agents (HP:0003221)	1.76730824
85	Petechiae (HP:0000967)	1.75900857
86	Duplication of thumb phalanx (HP:0009942)	1.75877103
87	Myositis (HP:0100614)	1.75055485
88	Thin ribs (HP:0000883)	1.74078863
89	Clonus (HP:0002169)	1.72358604
90	Abnormality of subcutaneous fat tissue (HP:0001001)	1.70893600
91	Abnormal tarsal ossification (HP:0008369)	1.68337769
92	Portal hypertension (HP:0001409)	1.65498150
93	Epistaxis (HP:0000421)	1.65187759
94	Gastrointestinal dysmotility (HP:0002579)	1.64906537
95	Focal segmental glomerulosclerosis (HP:0000097)	1.63366672
96	Pendular nystagmus (HP:0012043)	1.62622262
97	Premature graying of hair (HP:0002216)	1.61578277
98	Abnormal respiratory epithelium morphology (HP:0012253)	1.60018454
99	Abnormal respiratory motile cilium morphology (HP:0005938)	1.60018454
100	Persistence of primary teeth (HP:0006335)	1.58804645

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP2K3	6.22613277
2	MAP3K3	6.21491213
3	JAK3	3.93511215
4	FGR	3.52391449
5	CDK9	3.51425830
6	ACVR1B	3.17342387
7	RPS6KB2	2.94876354
8	MAP4K1	2.63166384
9	SGK494	2.54581456
10	SGK223	2.54581456
11	EPHB2	2.45453651
12	NTRK2	2.36992358
13	TRIB3	2.25092625
14	SGK2	2.18897912
15	ERN1	1.89304016
16	SMG1	1.88854354
17	SGK3	1.87253108
18	CCNB1	1.60860432
19	LMTK2	1.59969228
20	MAP3K11	1.57890515
21	CDK12	1.54903940
22	PAK4	1.44707920
23	PKN2	1.39042618
24	MAP2K1	1.35786574
25	PTK6	1.35404449
26	SIK1	1.32779929
27	MTOR	1.27909898
28	NTRK3	1.27476199
29	CAMK1D	1.14059041
30	NEK6	1.09068174
31	PRPF4B	1.07868626
32	STK10	1.05990164
33	ADRBK1	1.01938471
34	IRAK4	0.90763540
35	IRAK3	0.90163886
36	CDK7	0.84300846
37	ICK	0.82532203
38	HIPK2	0.79684805
39	IRAK2	0.75907236
40	CAMK1	0.75703891
41	AURKA	0.71361503
42	JAK2	0.70193925
43	CDK6	0.69905870
44	RPS6KA1	0.69366585
45	RPS6KB1	0.68807273
46	CSNK1A1	0.67342537
47	TTN	0.66392703
48	DYRK1B	0.58946434
49	PRKCI	0.58010095
50	SGK1	0.55966329
51	UHMK1	0.53939640
52	EPHA2	0.51372027
53	IKBKB	0.47779581
54	BRD4	0.46365531
55	INSR	0.45067089
56	RPS6KL1	0.44513742
57	RPS6KC1	0.44513742
58	CAMK1G	0.44145628
59	CAMK2B	0.41849740
60	PRKCD	0.40239377
61	GRK6	0.38786137
62	RPS6KA6	0.38288854
63	TNK2	0.38255807
64	MAPK8	0.38052658
65	PRKD1	0.37353113
66	EEF2K	0.37332126
67	MAPKAPK2	0.37188464
68	MAP3K7	0.36380573
69	PIM2	0.35487638
70	MAP3K1	0.35336476
71	MST1R	0.34845569
72	PRKD3	0.33137445
73	LCK	0.31561751
74	SYK	0.31403802
75	IRAK1	0.31311925
76	AKT1	0.30960405
77	BLK	0.30080152
78	PRKD2	0.30025734
79	BTK	0.29716367
80	YES1	0.29557167
81	TBK1	0.29501202
82	EGFR	0.29304615
83	MAP3K8	0.28650711
84	MAPK11	0.27491831
85	AKT2	0.26561486
86	TAOK2	0.25883488
87	PIM1	0.24658306
88	MAP3K10	0.24156026
89	PRKG2	0.23785240
90	ATR	0.23316540
91	CAMK2D	0.22832611
92	CAMK2G	0.21575736
93	CDK2	0.21224224
94	CDC42BPA	0.20488468
95	PRKCQ	0.18449212
96	CDK4	0.18212374
97	MAPK1	0.17963670
98	MAPK7	0.17687909
99	RIPK1	0.17434031
100	FGFR4	0.17144513

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	One carbon pool by folate_Homo sapiens_hsa00670	5.41912944
2	Arginine biosynthesis_Homo sapiens_hsa00220	5.23429662
3	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	4.10605125
4	Sulfur relay system_Homo sapiens_hsa04122	3.73028619
5	Sulfur metabolism_Homo sapiens_hsa00920	3.33568536
6	Collecting duct acid secretion_Homo sapiens_hsa04966	3.28180857
7	Galactose metabolism_Homo sapiens_hsa00052	2.97635613
8	Other glycan degradation_Homo sapiens_hsa00511	2.58346256
9	Biosynthesis of amino acids_Homo sapiens_hsa01230	2.52162944
10	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	2.35648869
11	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.35561425
12	Cysteine and methionine metabolism_Homo sapiens_hsa00270	2.28441753
13	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	2.07077234
14	Selenocompound metabolism_Homo sapiens_hsa00450	2.06188941
15	Morphine addiction_Homo sapiens_hsa05032	1.82549721
16	GABAergic synapse_Homo sapiens_hsa04727	1.81754739
17	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.76194535
18	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.75389251
19	Vibrio cholerae infection_Homo sapiens_hsa05110	1.65664507
20	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.44447535
21	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.43065882
22	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.37293472
23	Thyroid cancer_Homo sapiens_hsa05216	1.32063928
24	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.21142925
25	mRNA surveillance pathway_Homo sapiens_hsa03015	1.10637721
26	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	1.05129381
27	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	1.03954937
28	Retinol metabolism_Homo sapiens_hsa00830	1.00727439
29	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.96789372
30	Regulation of autophagy_Homo sapiens_hsa04140	0.96191641
31	Serotonergic synapse_Homo sapiens_hsa04726	0.94004392
32	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.92513554
33	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.92206205
34	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.90352321
35	Complement and coagulation cascades_Homo sapiens_hsa04610	0.90186929
36	Arginine and proline metabolism_Homo sapiens_hsa00330	0.89426799
37	Glutamatergic synapse_Homo sapiens_hsa04724	0.87039291
38	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.85921468
39	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.85448697
40	Nicotine addiction_Homo sapiens_hsa05033	0.74987908
41	Cholinergic synapse_Homo sapiens_hsa04725	0.73543905
42	Rheumatoid arthritis_Homo sapiens_hsa05323	0.71787239
43	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.70911107
44	Dopaminergic synapse_Homo sapiens_hsa04728	0.69890627
45	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.69839985
46	Phenylalanine metabolism_Homo sapiens_hsa00360	0.64963206
47	Prion diseases_Homo sapiens_hsa05020	0.63653886
48	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.61974179
49	ABC transporters_Homo sapiens_hsa02010	0.58083570
50	Osteoclast differentiation_Homo sapiens_hsa04380	0.56785233
51	Folate biosynthesis_Homo sapiens_hsa00790	0.53081886
52	Circadian entrainment_Homo sapiens_hsa04713	0.51965269
53	PPAR signaling pathway_Homo sapiens_hsa03320	0.50336809
54	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.50264302
55	Carbon metabolism_Homo sapiens_hsa01200	0.49629472
56	Alcoholism_Homo sapiens_hsa05034	0.48946538
57	Chemokine signaling pathway_Homo sapiens_hsa04062	0.45070173
58	AMPK signaling pathway_Homo sapiens_hsa04152	0.44280442
59	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.42055955
60	Pentose phosphate pathway_Homo sapiens_hsa00030	0.41174765
61	Ras signaling pathway_Homo sapiens_hsa04014	0.41104001
62	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.41103790
63	Acute myeloid leukemia_Homo sapiens_hsa05221	0.40576525
64	Influenza A_Homo sapiens_hsa05164	0.39026624
65	Nitrogen metabolism_Homo sapiens_hsa00910	0.36819757
66	GnRH signaling pathway_Homo sapiens_hsa04912	0.35717849
67	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.35573096
68	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.33055361
69	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.32487418
70	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.31353329
71	Pertussis_Homo sapiens_hsa05133	0.31191085
72	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.31167862
73	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.29112825
74	Base excision repair_Homo sapiens_hsa03410	0.28956279
75	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.27537870
76	TNF signaling pathway_Homo sapiens_hsa04668	0.27016283
77	PI3K-Akt signaling pathway_Homo sapiens_hsa04151	0.26669501
78	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.25587284
79	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.24534718
80	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.23700628
81	Bile secretion_Homo sapiens_hsa04976	0.23694476
82	Adherens junction_Homo sapiens_hsa04520	0.21474172
83	HTLV-I infection_Homo sapiens_hsa05166	0.21265825
84	Legionellosis_Homo sapiens_hsa05134	0.21153020
85	Phagosome_Homo sapiens_hsa04145	0.21151193
86	Metabolic pathways_Homo sapiens_hsa01100	0.17192279
87	Peroxisome_Homo sapiens_hsa04146	0.17061675
88	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.15984636
89	Ether lipid metabolism_Homo sapiens_hsa00565	0.15964297
90	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.15126010
91	Apoptosis_Homo sapiens_hsa04210	0.13641659
92	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.13532057
93	African trypanosomiasis_Homo sapiens_hsa05143	0.12544559
94	Non-small cell lung cancer_Homo sapiens_hsa05223	0.12309611
95	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.10962084
96	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.10525612
97	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.09999137
98	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.09916252
99	Renal cell carcinoma_Homo sapiens_hsa05211	0.09722247
100	Spliceosome_Homo sapiens_hsa03040	0.09076739

ABHD17AP1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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