ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	7.65218536
2	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	7.65218536
3	homocysteine metabolic process (GO:0050667)	5.59074345
4	purine nucleotide salvage (GO:0032261)	5.48749907
5	ribosomal small subunit assembly (GO:0000028)	5.22115697
6	regulation of plasminogen activation (GO:0010755)	5.17012239
7	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	4.92229686
8	sulfur amino acid catabolic process (GO:0000098)	4.88880455
9	adenosine metabolic process (GO:0046085)	4.88746308
10	white fat cell differentiation (GO:0050872)	4.85785871
11	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	4.85119041
12	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	4.74233304
13	definitive hemopoiesis (GO:0060216)	4.63114423
14	positive regulation of glycoprotein biosynthetic process (GO:0010560)	4.52222681
15	regulation of protein glycosylation (GO:0060049)	4.47029559
16	neutrophil activation involved in immune response (GO:0002283)	4.35357601
17	diacylglycerol metabolic process (GO:0046339)	4.33053720
18	phosphatidylglycerol biosynthetic process (GO:0006655)	4.31401923
19	pyrimidine nucleotide catabolic process (GO:0006244)	4.30537592
20	negative regulation of DNA biosynthetic process (GO:2000279)	4.22579377
21	regulation of tight junction assembly (GO:2000810)	4.18706492
22	ubiquinone biosynthetic process (GO:0006744)	4.17674353
23	folic acid-containing compound biosynthetic process (GO:0009396)	4.14094029
24	deoxyribose phosphate biosynthetic process (GO:0046385)	4.12609248
25	2-deoxyribonucleotide biosynthetic process (GO:0009265)	4.12609248
26	protein polyglutamylation (GO:0018095)	4.11696433
27	acrosome assembly (GO:0001675)	4.08505705
28	activated T cell proliferation (GO:0050798)	4.02321479
29	nucleotide salvage (GO:0043173)	4.00392929
30	autophagic vacuole fusion (GO:0000046)	3.99922806
31	ncRNA 3-end processing (GO:0043628)	3.87938607
32	pathway-restricted SMAD protein phosphorylation (GO:0060389)	3.84212199
33	positive regulation of glycoprotein metabolic process (GO:1903020)	3.78603027
34	epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)	3.77122261
35	spermatid nucleus differentiation (GO:0007289)	3.74602926
36	DNA methylation involved in gamete generation (GO:0043046)	3.72369255
37	microtubule nucleation (GO:0007020)	3.69667785
38	positive regulation of B cell differentiation (GO:0045579)	3.66947055
39	positive regulation of endothelial cell differentiation (GO:0045603)	3.65499603
40	ubiquinone metabolic process (GO:0006743)	3.59244028
41	organic cation transport (GO:0015695)	3.56636192
42	estrogen biosynthetic process (GO:0006703)	3.55226198
43	negative regulation of blood vessel endothelial cell migration (GO:0043537)	3.53386763
44	quinone biosynthetic process (GO:1901663)	3.48759737
45	synaptonemal complex assembly (GO:0007130)	3.44195358
46	nucleoside transmembrane transport (GO:1901642)	3.40339565
47	cysteine metabolic process (GO:0006534)	3.39048736
48	regulation of sequestering of triglyceride (GO:0010889)	3.37146634
49	regulation of gonadotropin secretion (GO:0032276)	3.35384208
50	mitochondrial RNA metabolic process (GO:0000959)	3.33762361
51	platelet dense granule organization (GO:0060155)	3.32369177
52	embryonic body morphogenesis (GO:0010172)	3.30802604
53	transcription from RNA polymerase I promoter (GO:0006360)	3.30392005
54	regulation of antigen processing and presentation (GO:0002577)	3.22418509
55	xenobiotic catabolic process (GO:0042178)	3.19920033
56	negative regulation of execution phase of apoptosis (GO:1900118)	3.19017121
57	alternative mRNA splicing, via spliceosome (GO:0000380)	3.13581601
58	organelle membrane fusion (GO:0090174)	3.12201862
59	energy homeostasis (GO:0097009)	3.09270677
60	aminoglycoside antibiotic metabolic process (GO:0030647)	3.09245231
61	meiotic chromosome segregation (GO:0045132)	3.06086203
62	cellular anion homeostasis (GO:0030002)	3.05572025
63	negative regulation of catenin import into nucleus (GO:0035414)	3.01320702
64	antigen processing and presentation of endogenous antigen (GO:0019883)	3.00893573
65	embryonic process involved in female pregnancy (GO:0060136)	2.99441584
66	positive regulation of odontogenesis (GO:0042482)	2.97830394
67	protein-cofactor linkage (GO:0018065)	2.97823271
68	histone H4-K12 acetylation (GO:0043983)	2.96151770
69	piRNA metabolic process (GO:0034587)	2.95398864
70	regulation of interleukin-8 secretion (GO:2000482)	2.94726740
71	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.92566315
72	chromosome organization involved in meiosis (GO:0070192)	2.92027690
73	synaptonemal complex organization (GO:0070193)	2.91634587
74	regulation of telomerase activity (GO:0051972)	2.90334892
75	NADH dehydrogenase complex assembly (GO:0010257)	2.88116474
76	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.88116474
77	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.88116474
78	heterotypic cell-cell adhesion (GO:0034113)	2.86621738
79	leukocyte cell-cell adhesion (GO:0007159)	2.86029916
80	response to misfolded protein (GO:0051788)	2.84974664
81	regulation of tumor necrosis factor-mediated signaling pathway (GO:0010803)	2.84361482
82	positive regulation of peptidyl-lysine acetylation (GO:2000758)	2.83275063
83	positive regulation of protein acetylation (GO:1901985)	2.83275063
84	GPI anchor biosynthetic process (GO:0006506)	2.80092903
85	protein-chromophore linkage (GO:0018298)	2.79175101
86	cell migration involved in heart development (GO:0060973)	2.78646005
87	tRNA modification (GO:0006400)	2.77202810
88	response to caffeine (GO:0031000)	2.76604719
89	regulation of vitamin D biosynthetic process (GO:0060556)	2.76111501
90	regulation of metalloenzyme activity (GO:0048552)	2.75336570
91	synapsis (GO:0007129)	2.74584529
92	polyamine biosynthetic process (GO:0006596)	2.74544557
93	GPI anchor metabolic process (GO:0006505)	2.73079521
94	negative regulation of telomerase activity (GO:0051974)	2.70825983
95	positive regulation of antigen processing and presentation (GO:0002579)	2.70825771
96	cellular response to heat (GO:0034605)	2.68767353
97	aggressive behavior (GO:0002118)	2.67404597
98	pteridine-containing compound biosynthetic process (GO:0042559)	2.66236619
99	negative regulation of sodium ion transport (GO:0010766)	2.64612313
100	purine-containing compound salvage (GO:0043101)	2.64428026

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	IRF8_22096565_ChIP-ChIP_GC-B_Human	3.95539893
2	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	3.76925490
3	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.55133277
4	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.35561059
5	BP1_19119308_ChIP-ChIP_Hs578T_Human	3.28751236
6	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.25352891
7	SCL_19346495_ChIP-Seq_HPC-7_Human	2.89552275
8	YY1_22570637_ChIP-Seq_MALME-3M_Human	2.24455745
9	BCL6_27268052_Chip-Seq_Bcells_Human	2.03671012
10	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.03274449
11	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	10.5818388
12	BCOR_27268052_Chip-Seq_Bcells_Human	1.82783534
13	MECOM_23826213_ChIP-Seq_KASUMI_Mouse	1.76994873
14	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.75672987
15	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.70584236
16	GATA2_20887958_ChIP-Seq_HPC-7_Mouse	1.67150430
17	MYC_22102868_ChIP-Seq_BL_Human	1.65692414
18	E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human	1.63900700
19	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.63184560
20	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.60504488
21	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.58966956
22	P68_20966046_ChIP-Seq_HELA_Human	1.58383376
23	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.57056158
24	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	1.56824906
25	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.55648344
26	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.54256269
27	UTX_26944678_Chip-Seq_JUKART_Human	1.53271360
28	RUNX_20019798_ChIP-Seq_JUKART_Human	1.50131860
29	P300_27268052_Chip-Seq_Bcells_Human	1.44003755
30	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.43261627
31	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.43098888
32	VDR_21846776_ChIP-Seq_THP-1_Human	1.42541125
33	MYB_26560356_Chip-Seq_TH2_Human	1.40567419
34	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.39332124
35	LXR_22292898_ChIP-Seq_THP-1_Human	1.38733366
36	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.37262865
37	PHF8_20622854_ChIP-Seq_HELA_Human	1.33965727
38	MEIS1_20887958_ChIP-Seq_HPC-7_Mouse	1.32427932
39	TAF2_19829295_ChIP-Seq_ESCs_Human	1.32118591
40	SPI1_20517297_ChIP-Seq_HL60_Human	1.31628232
41	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.31234052
42	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.30702763
43	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.23001317
44	LMO2_20887958_ChIP-Seq_HPC-7_Mouse	1.22982326
45	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.21325889
46	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.21255257
47	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.21177766
48	SPI1_23547873_ChIP-Seq_NB4_Human	1.19099547
49	GATA1_22383799_ChIP-Seq_G1ME_Mouse	1.18039042
50	MAF_26560356_Chip-Seq_TH2_Human	1.16752753
51	VDR_24763502_ChIP-Seq_THP-1_Human	1.15896883
52	CTCF_20526341_ChIP-Seq_ESCs_Human	1.15769915
53	CIITA_25753668_ChIP-Seq_RAJI_Human	1.15159927
54	E2F1_20622854_ChIP-Seq_HELA_Human	1.13759555
55	RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.12782252
56	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.11278313
57	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.10348875
58	DNAJC2_21179169_ChIP-ChIP_NT2_Human	1.09518981
59	ETS1_21867929_ChIP-Seq_TH2_Mouse	1.09254430
60	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.06306752
61	CTCF_26484167_Chip-Seq_Bcells_Mouse	1.05434954
62	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.04202204
63	GATA3_21867929_ChIP-Seq_TH1_Mouse	1.03815009
64	CTCF_21964334_ChIP-Seq_BJAB-B_Human	1.03461727
65	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.03223981
66	TP53_22573176_ChIP-Seq_HFKS_Human	1.00650179
67	CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.99494822
68	FLI1_21867929_ChIP-Seq_CD8_Mouse	0.99414098
69	SOX2_21211035_ChIP-Seq_LN229_Human	0.99091174
70	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.98957064
71	VDR_22108803_ChIP-Seq_LS180_Human	0.98854440
72	STAT3_19079543_ChIP-ChIP_MESCs_Mouse	0.97203648
73	TP53_20018659_ChIP-ChIP_R1E_Mouse	0.96039474
74	TP53_22127205_ChIP-Seq_IMR90_Human	0.95909994
75	PU.1_20513432_ChIP-Seq_Bcells_Mouse	0.93854324
76	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.93164776
77	VDR_23849224_ChIP-Seq_CD4+_Human	0.92939589
78	GATA2_22383799_ChIP-Seq_G1ME_Mouse	0.90385633
79	CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse	0.89909209
80	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	0.89621559
81	ERG_20517297_ChIP-Seq_VCAP_Human	0.88475198
82	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	0.88198916
83	CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse	0.88089039
84	NCOR1_26117541_ChIP-Seq_K562_Human	0.87990802
85	BRD4_27068464_Chip-Seq_AML-cells_Mouse	0.87618523
86	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.87189001
87	RUNX1_22412390_ChIP-Seq_EML_Mouse	0.86807232
88	CTCF_21964334_Chip-Seq_Bcells_Human	0.86342695
89	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	0.85692191
90	FOXP3_21729870_ChIP-Seq_TREG_Human	0.85577449
91	TBX5_21415370_ChIP-Seq_HL-1_Mouse	0.85534263
92	OCT4_20526341_ChIP-Seq_ESCs_Human	0.84369044
93	SMC4_20622854_ChIP-Seq_HELA_Human	0.84348630
94	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.84178466
95	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	0.83835909
96	MYB_26560356_Chip-Seq_TH1_Human	0.83816887
97	CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse	0.83734186
98	GATA1_19941826_ChIP-Seq_K562_Human	0.83626722
99	MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human	0.83539846
100	ERA_21632823_ChIP-Seq_H3396_Human	0.83504859

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005360_urolithiasis	3.73870207
2	MP0005646_abnormal_pituitary_gland	3.46550495
3	MP0001851_eye_inflammation	3.24665935
4	MP0003183_abnormal_peptide_metabolism	2.81330962
5	MP0005670_abnormal_white_adipose	2.78117455
6	MP0002933_joint_inflammation	2.64971862
7	MP0001661_extended_life_span	2.53160675
8	MP0008995_early_reproductive_senescence	2.45372814
9	MP0000465_gastrointestinal_hemorrhage	2.41156949
10	MP0003724_increased_susceptibility_to	2.32416110
11	MP0001800_abnormal_humoral_immune	2.15852569
12	MP0002095_abnormal_skin_pigmentation	2.08393167
13	MP0004147_increased_porphyrin_level	2.07072219
14	MP0000013_abnormal_adipose_tissue	2.04147768
15	MP0003646_muscle_fatigue	2.02440573
16	MP0001968_abnormal_touch/_nociception	1.93256890
17	MP0002735_abnormal_chemical_nociception	1.83618495
18	MP0001835_abnormal_antigen_presentation	1.76880490
19	MP0003567_abnormal_fetal_cardiomyocyte	1.76704740
20	MP0002160_abnormal_reproductive_system	1.75400390
21	MP0001905_abnormal_dopamine_level	1.73585464
22	MP0002396_abnormal_hematopoietic_system	1.73294432
23	MP0005000_abnormal_immune_tolerance	1.68431282
24	MP0003172_abnormal_lysosome_physiology	1.64973712
25	MP0002139_abnormal_hepatobiliary_system	1.59711601
26	MP0000516_abnormal_urinary_system	1.59456747
27	MP0005367_renal/urinary_system_phenotyp	1.59456747
28	MP0002452_abnormal_antigen_presenting	1.57351014
29	MP0005645_abnormal_hypothalamus_physiol	1.57335112
30	MP0002723_abnormal_immune_serum	1.54700049
31	MP0002736_abnormal_nociception_after	1.54547314
32	MP0004947_skin_inflammation	1.51528697
33	MP0006292_abnormal_olfactory_placode	1.42223538
34	MP0002419_abnormal_innate_immunity	1.40784810
35	MP0000678_abnormal_parathyroid_gland	1.39841324
36	MP0005025_abnormal_response_to	1.38536441
37	MP0004885_abnormal_endolymph	1.36226638
38	MP0004043_abnormal_pH_regulation	1.35471759
39	MP0002398_abnormal_bone_marrow	1.33146293
40	MP0002420_abnormal_adaptive_immunity	1.31808328
41	MP0004233_abnormal_muscle_weight	1.29087007
42	MP0008469_abnormal_protein_level	1.27295598
43	MP0002148_abnormal_hypersensitivity_rea	1.27205624
44	MP0000689_abnormal_spleen_morphology	1.27057481
45	MP0004185_abnormal_adipocyte_glucose	1.26806971
46	MP0000230_abnormal_systemic_arterial	1.26235792
47	MP0005671_abnormal_response_to	1.23789364
48	MP0001819_abnormal_immune_cell	1.23571893
49	MP0005253_abnormal_eye_physiology	1.22019046
50	MP0001502_abnormal_circadian_rhythm	1.21963933
51	MP0005387_immune_system_phenotype	1.21739503
52	MP0001790_abnormal_immune_system	1.21739503
53	MP0001764_abnormal_homeostasis	1.21495600
54	MP0008875_abnormal_xenobiotic_pharmacok	1.20376076
55	MP0008260_abnormal_autophagy	1.18845526
56	MP0009278_abnormal_bone_marrow	1.18559157
57	MP0008872_abnormal_physiological_respon	1.17321242
58	MP0003763_abnormal_thymus_physiology	1.15261589
59	MP0008877_abnormal_DNA_methylation	1.11197993
60	MP0002876_abnormal_thyroid_physiology	1.11060394
61	MP0000716_abnormal_immune_system	1.09659967
62	MP0003705_abnormal_hypodermis_morpholog	1.09166778
63	MP0002210_abnormal_sex_determination	1.07929306
64	MP0003436_decreased_susceptibility_to	1.05660298
65	MP0003806_abnormal_nucleotide_metabolis	1.04411285
66	MP0000681_abnormal_thyroid_gland	1.04021482
67	MP0010386_abnormal_urinary_bladder	1.03520113
68	MP0005551_abnormal_eye_electrophysiolog	1.03273250
69	MP0002722_abnormal_immune_system	1.02457389
70	MP0003186_abnormal_redox_activity	0.97754155
71	MP0002429_abnormal_blood_cell	0.96946369
72	MP0005595_abnormal_vascular_smooth	0.96067185
73	MP0001929_abnormal_gametogenesis	0.95839376
74	MP0009643_abnormal_urine_homeostasis	0.94603577
75	MP0000003_abnormal_adipose_tissue	0.90993467
76	MP0005197_abnormal_uvea_morphology	0.90875987
77	MP0006276_abnormal_autonomic_nervous	0.89632599
78	MP0001145_abnormal_male_reproductive	0.88057340
79	MP0002837_dystrophic_cardiac_calcinosis	0.86814221
80	MP0005397_hematopoietic_system_phenotyp	0.86798188
81	MP0001545_abnormal_hematopoietic_system	0.86798188
82	MP0000653_abnormal_sex_gland	0.84204089
83	MP0005075_abnormal_melanosome_morpholog	0.84056763
84	MP0001845_abnormal_inflammatory_respons	0.83915249
85	MP0009785_altered_susceptibility_to	0.82882071
86	MP0009384_cardiac_valve_regurgitation	0.82461368
87	MP0006036_abnormal_mitochondrial_physio	0.82385789
88	MP0003315_abnormal_perineum_morphology	0.82297095
89	MP0002822_catalepsy	0.80765211
90	MP0005332_abnormal_amino_acid	0.79747424
91	MP0002277_abnormal_respiratory_mucosa	0.78642522
92	MP0005464_abnormal_platelet_physiology	0.78525069
93	MP0001986_abnormal_taste_sensitivity	0.78086276
94	MP0009764_decreased_sensitivity_to	0.75287767
95	MP0003698_abnormal_male_reproductive	0.73280085
96	MP0002138_abnormal_hepatobiliary_system	0.71912984
97	MP0005636_abnormal_mineral_homeostasis	0.70370421
98	MP0002132_abnormal_respiratory_system	0.69825149
99	MP0002234_abnormal_pharynx_morphology	0.69443404
100	MP0002115_abnormal_skeleton_extremities	0.69377573

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Recurrent gram-negative bacterial infections (HP:0005420)	7.26139783
2	Recurrent abscess formation (HP:0002722)	5.21092337
3	Abnormality of alanine metabolism (HP:0010916)	5.21000231
4	Hyperalaninemia (HP:0003348)	5.21000231
5	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	5.21000231
6	Constricted visual fields (HP:0001133)	4.43493523
7	Periodontitis (HP:0000704)	4.37449937
8	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	4.11440289
9	Spontaneous hematomas (HP:0007420)	3.95835272
10	Decreased electroretinogram (ERG) amplitude (HP:0000654)	3.89753729
11	Leukocytosis (HP:0001974)	3.80035723
12	Elevated erythrocyte sedimentation rate (HP:0003565)	3.63445317
13	Agammaglobulinemia (HP:0004432)	3.47218031
14	Cortical visual impairment (HP:0100704)	3.34696980
15	Gingivitis (HP:0000230)	3.33731112
16	Cellulitis (HP:0100658)	3.30426195
17	Autoimmune hemolytic anemia (HP:0001890)	3.27922351
18	Cone-rod dystrophy (HP:0000548)	3.26674285
19	Attenuation of retinal blood vessels (HP:0007843)	3.26635646
20	Congenital sensorineural hearing impairment (HP:0008527)	3.25444272
21	Increased IgM level (HP:0003496)	3.22001960
22	Pulmonary embolism (HP:0002204)	3.06950360
23	Chronic bronchitis (HP:0004469)	3.06207284
24	Maternal diabetes (HP:0009800)	3.02624660
25	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.97561245
26	Hypertensive crisis (HP:0100735)	2.88810195
27	Esophageal varix (HP:0002040)	2.86657496
28	Patchy hypopigmentation of hair (HP:0011365)	2.85118794
29	Granulocytopenia (HP:0001913)	2.82005627
30	White forelock (HP:0002211)	2.78495117
31	Abnormal delayed hypersensitivity skin test (HP:0002963)	2.78164906
32	Reduced antithrombin III activity (HP:0001976)	2.74464310
33	Poor speech (HP:0002465)	2.72565526
34	Sparse scalp hair (HP:0002209)	2.72515433
35	Chronic sinusitis (HP:0011109)	2.70296291
36	Abnormality of the fetal cardiovascular system (HP:0010948)	2.67066503
37	Abnormal umbilical cord blood vessels (HP:0011403)	2.67066503
38	Single umbilical artery (HP:0001195)	2.67066503
39	Thrombophlebitis (HP:0004418)	2.66642792
40	Microcytic anemia (HP:0001935)	2.58797565
41	Abnormality of the tricuspid valve (HP:0001702)	2.52756751
42	Abnormality of macular pigmentation (HP:0008002)	2.52186901
43	Conjunctival telangiectasia (HP:0000524)	2.50697241
44	Abnormality of the intervertebral disk (HP:0005108)	2.45386494
45	Chronic obstructive pulmonary disease (HP:0006510)	2.44018225
46	Obstructive lung disease (HP:0006536)	2.44018225
47	Anorexia (HP:0002039)	2.42427828
48	Epistaxis (HP:0000421)	2.39696151
49	Deep philtrum (HP:0002002)	2.37365023
50	Hypergammaglobulinemia (HP:0010702)	2.36768590
51	3-Methylglutaconic aciduria (HP:0003535)	2.36111592
52	Chronic otitis media (HP:0000389)	2.34645925
53	Abolished electroretinogram (ERG) (HP:0000550)	2.32409010
54	Autoimmune thrombocytopenia (HP:0001973)	2.30236276
55	Pigmentary retinal degeneration (HP:0001146)	2.24130420
56	Abnormality of the vasculature of the conjunctiva (HP:0008054)	2.21773235
57	Seborrheic dermatitis (HP:0001051)	2.20769044
58	Urticaria (HP:0001025)	2.19821750
59	Abnormality of serum amino acid levels (HP:0003112)	2.19665374
60	Facial hemangioma (HP:0000329)	2.18495111
61	Bronchitis (HP:0012387)	2.18478018
62	Birth length less than 3rd percentile (HP:0003561)	2.13285088
63	Cerebellar dysplasia (HP:0007033)	2.13009930
64	Meningitis (HP:0001287)	2.12728483
65	Abnormality of homocysteine metabolism (HP:0010919)	2.12043507
66	Homocystinuria (HP:0002156)	2.12043507
67	Oligomenorrhea (HP:0000876)	2.11907547
68	Nasal speech (HP:0001611)	2.09334787
69	Hyperglycinemia (HP:0002154)	2.05117759
70	Gingival bleeding (HP:0000225)	2.03923258
71	Recurrent sinusitis (HP:0011108)	2.01530321
72	Conjugated hyperbilirubinemia (HP:0002908)	1.98363709
73	Myocardial infarction (HP:0001658)	1.94217574
74	Abnormal protein N-linked glycosylation (HP:0012347)	1.91621993
75	Abnormal protein glycosylation (HP:0012346)	1.91621993
76	Abnormal glycosylation (HP:0012345)	1.91621993
77	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.91621993
78	Truncus arteriosus (HP:0001660)	1.91122454
79	Chorioretinal atrophy (HP:0000533)	1.90742053
80	Hyperthyroidism (HP:0000836)	1.90472150
81	Abnormality of the renal collecting system (HP:0004742)	1.89854412
82	Biconcave vertebral bodies (HP:0004586)	1.89036397
83	Abnormality of eosinophils (HP:0001879)	1.87823243
84	Eosinophilia (HP:0001880)	1.87045494
85	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.85856131
86	Dicarboxylic aciduria (HP:0003215)	1.84136319
87	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.84136319
88	Bowel incontinence (HP:0002607)	1.83075079
89	Petechiae (HP:0000967)	1.82552271
90	Abnormality of magnesium homeostasis (HP:0004921)	1.81235960
91	Hypoparathyroidism (HP:0000829)	1.78991438
92	Mediastinal lymphadenopathy (HP:0100721)	1.78327274
93	Prolonged bleeding time (HP:0003010)	1.78300246
94	Slender long bone (HP:0003100)	1.77087723
95	Thoracic kyphosis (HP:0002942)	1.75468148
96	Tetany (HP:0001281)	1.73664874
97	Decreased central vision (HP:0007663)	1.73155698
98	Recurrent fungal infections (HP:0002841)	1.73093984
99	Premature graying of hair (HP:0002216)	1.71947404
100	Vasculitis (HP:0002633)	1.71864417

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PBK	5.51491075
2	MAP4K1	3.87382658
3	PRKCH	3.78883501
4	DAPK1	3.02866433
5	MAP2K3	2.71804828
6	FES	2.50746088
7	TXK	2.50541864
8	JAK3	2.38063245
9	ICK	2.31393162
10	KDR	1.99964823
11	NTRK3	1.91633276
12	CDK9	1.89754547
13	BCKDK	1.89594577
14	ERN1	1.84466444
15	MAP3K3	1.78150709
16	NTRK2	1.75688175
17	TAOK3	1.75172809
18	FGR	1.60041691
19	ADRBK1	1.57937044
20	GRK6	1.46892060
21	DAPK2	1.45127935
22	ACVR1B	1.42962870
23	MAP3K13	1.35144637
24	TLK1	1.31349711
25	PKN1	1.31228063
26	MAP3K11	1.28267431
27	ZAK	1.26148460
28	LCK	1.25718987
29	PRKCD	1.18589857
30	RPS6KB2	1.17690921
31	PRKCQ	1.13246599
32	TESK2	1.11862664
33	DAPK3	1.10092400
34	CCNB1	1.07322715
35	CAMK2B	1.05505934
36	PRKD2	1.03603331
37	VRK2	1.03526423
38	RPS6KL1	1.03047762
39	RPS6KC1	1.03047762
40	MAP3K1	1.01158846
41	AURKA	1.00683757
42	RPS6KA6	1.00404598
43	TBK1	0.99661114
44	IRAK4	0.98915282
45	SYK	0.98881896
46	PIM2	0.92821767
47	KIT	0.92676990
48	DYRK1B	0.90586102
49	MAP3K7	0.90544634
50	IKBKB	0.88098914
51	CAMK2D	0.87079308
52	CAMK2G	0.84536967
53	MAP2K7	0.81960927
54	VRK1	0.72599442
55	SGK494	0.71101373
56	SGK223	0.71101373
57	CSK	0.69989258
58	JAK2	0.67926077
59	TYRO3	0.67652209
60	PRKD1	0.67415759
61	MAP2K1	0.65877875
62	BTK	0.65325959
63	CSF1R	0.64275217
64	ATR	0.62601249
65	CAMK1	0.61751288
66	RPS6KA2	0.61177517
67	STK38	0.60107989
68	SGK2	0.59976138
69	CAMK2A	0.59458866
70	MAPK13	0.58730305
71	LYN	0.58410335
72	PIM1	0.55232752
73	FLT3	0.54740241
74	MAPK4	0.52306788
75	RPS6KA1	0.51062585
76	HIPK2	0.50414817
77	MAPKAPK2	0.50167370
78	TYK2	0.49536060
79	NEK2	0.48782992
80	MAPK15	0.48123431
81	NUAK1	0.47279366
82	TNK2	0.45841262
83	PRKCA	0.45801195
84	MAPK11	0.43871188
85	TAF1	0.43836383
86	PINK1	0.43641996
87	MAP3K4	0.42887862
88	CDK7	0.40798128
89	DYRK2	0.38617238
90	MAPK3	0.37829766
91	ADRBK2	0.37575644
92	MAP3K6	0.36943397
93	RPS6KA5	0.36563558
94	TEC	0.34764582
95	MAP3K5	0.33695418
96	RPS6KB1	0.33605368
97	FYN	0.33392637
98	ABL2	0.33122787
99	SRC	0.32816372
100	CSNK1A1	0.31959369

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	RNA polymerase_Homo sapiens_hsa03020	3.29974054
2	Graft-versus-host disease_Homo sapiens_hsa05332	3.20899856
3	Autoimmune thyroid disease_Homo sapiens_hsa05320	3.11363076
4	Allograft rejection_Homo sapiens_hsa05330	3.06493191
5	Type I diabetes mellitus_Homo sapiens_hsa04940	2.69388616
6	Staphylococcus aureus infection_Homo sapiens_hsa05150	2.68999420
7	Viral myocarditis_Homo sapiens_hsa05416	2.62255619
8	Primary immunodeficiency_Homo sapiens_hsa05340	2.42296277
9	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.27725508
10	Leishmaniasis_Homo sapiens_hsa05140	2.27188191
11	Rheumatoid arthritis_Homo sapiens_hsa05323	2.15419034
12	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	2.14491124
13	Asthma_Homo sapiens_hsa05310	2.13014635
14	Glycerophospholipid metabolism_Homo sapiens_hsa00564	2.08019197
15	Malaria_Homo sapiens_hsa05144	1.91578836
16	One carbon pool by folate_Homo sapiens_hsa00670	1.77447749
17	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.74352898
18	Sulfur relay system_Homo sapiens_hsa04122	1.73901470
19	Legionellosis_Homo sapiens_hsa05134	1.67685041
20	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.67187367
21	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.65139928
22	Pertussis_Homo sapiens_hsa05133	1.50912797
23	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.45920015
24	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.44036833
25	Selenocompound metabolism_Homo sapiens_hsa00450	1.43673986
26	Arginine biosynthesis_Homo sapiens_hsa00220	1.43242520
27	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.40870083
28	Pyrimidine metabolism_Homo sapiens_hsa00240	1.40545409
29	Linoleic acid metabolism_Homo sapiens_hsa00591	1.34666667
30	Collecting duct acid secretion_Homo sapiens_hsa04966	1.31800687
31	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.30360758
32	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.28784258
33	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.23288859
34	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.16466580
35	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.15374376
36	Antigen processing and presentation_Homo sapiens_hsa04612	1.13121516
37	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.10807052
38	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	1.07547560
39	Homologous recombination_Homo sapiens_hsa03440	1.01631196
40	Sulfur metabolism_Homo sapiens_hsa00920	0.99695226
41	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.99156607
42	Base excision repair_Homo sapiens_hsa03410	0.95398172
43	Ribosome_Homo sapiens_hsa03010	0.94862579
44	Alcoholism_Homo sapiens_hsa05034	0.94148319
45	Ether lipid metabolism_Homo sapiens_hsa00565	0.93406792
46	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.91068543
47	Glycerolipid metabolism_Homo sapiens_hsa00561	0.89264015
48	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.88363238
49	Purine metabolism_Homo sapiens_hsa00230	0.84673470
50	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.81032201
51	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.80360848
52	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.80056007
53	Olfactory transduction_Homo sapiens_hsa04740	0.78461665
54	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.76807733
55	Morphine addiction_Homo sapiens_hsa05032	0.76171744
56	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.73088868
57	Herpes simplex infection_Homo sapiens_hsa05168	0.71396234
58	African trypanosomiasis_Homo sapiens_hsa05143	0.70513775
59	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.68552907
60	Basal transcription factors_Homo sapiens_hsa03022	0.68394492
61	Serotonergic synapse_Homo sapiens_hsa04726	0.67004862
62	Tuberculosis_Homo sapiens_hsa05152	0.66881440
63	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.66564251
64	Regulation of autophagy_Homo sapiens_hsa04140	0.66550374
65	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.65069815
66	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.64103920
67	Acute myeloid leukemia_Homo sapiens_hsa05221	0.63966154
68	Osteoclast differentiation_Homo sapiens_hsa04380	0.62551666
69	Non-small cell lung cancer_Homo sapiens_hsa05223	0.61377355
70	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.59219299
71	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.57432780
72	Phagosome_Homo sapiens_hsa04145	0.52809987
73	Non-homologous end-joining_Homo sapiens_hsa03450	0.51534445
74	Chemical carcinogenesis_Homo sapiens_hsa05204	0.51432021
75	ABC transporters_Homo sapiens_hsa02010	0.50233703
76	Spliceosome_Homo sapiens_hsa03040	0.49997456
77	Retinol metabolism_Homo sapiens_hsa00830	0.49596904
78	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.48704455
79	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.48330083
80	Ras signaling pathway_Homo sapiens_hsa04014	0.46633396
81	Nitrogen metabolism_Homo sapiens_hsa00910	0.46124492
82	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.45743775
83	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.45266092
84	Complement and coagulation cascades_Homo sapiens_hsa04610	0.42375436
85	Platelet activation_Homo sapiens_hsa04611	0.40231843
86	Glutathione metabolism_Homo sapiens_hsa00480	0.39908510
87	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.39463750
88	HTLV-I infection_Homo sapiens_hsa05166	0.38230625
89	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.36648842
90	Measles_Homo sapiens_hsa05162	0.36609412
91	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.36332069
92	Peroxisome_Homo sapiens_hsa04146	0.35148762
93	Fat digestion and absorption_Homo sapiens_hsa04975	0.34707409
94	Nicotine addiction_Homo sapiens_hsa05033	0.34622390
95	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.32670252
96	Metabolic pathways_Homo sapiens_hsa01100	0.31963029
97	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.31462370
98	Taste transduction_Homo sapiens_hsa04742	0.30700249
99	GABAergic synapse_Homo sapiens_hsa04727	0.30645911
100	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.30331295

ABHD17AP3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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