ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	pyrimidine-containing compound transmembrane transport (GO:0072531)	9.57868026
2	purine nucleotide salvage (GO:0032261)	7.66418048
3	folic acid-containing compound biosynthetic process (GO:0009396)	7.32864420
4	adenosine metabolic process (GO:0046085)	7.23823916
5	nucleoside transmembrane transport (GO:1901642)	6.62038580
6	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	6.36015511
7	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	6.36015511
8	vitamin transmembrane transport (GO:0035461)	6.23643857
9	cysteine metabolic process (GO:0006534)	6.22874252
10	homocysteine metabolic process (GO:0050667)	6.11518158
11	folic acid transport (GO:0015884)	6.10226100
12	IMP biosynthetic process (GO:0006188)	5.49402211
13	kinetochore assembly (GO:0051382)	5.45633234
14	IMP metabolic process (GO:0046040)	4.82971418
15	regulation of plasminogen activation (GO:0010755)	4.81221925
16	purine-containing compound salvage (GO:0043101)	4.68632579
17	protein-cofactor linkage (GO:0018065)	4.65611067
18	nucleoside transport (GO:0015858)	4.60598969
19	nucleotide salvage (GO:0043173)	4.55879982
20	protein-chromophore linkage (GO:0018298)	4.55779520
21	pteridine-containing compound biosynthetic process (GO:0042559)	4.42331584
22	mitochondrial RNA metabolic process (GO:0000959)	4.41932723
23	kinetochore organization (GO:0051383)	4.29854697
24	ubiquinone biosynthetic process (GO:0006744)	4.28371953
25	sulfur amino acid catabolic process (GO:0000098)	4.20772917
26	positive regulation of B cell differentiation (GO:0045579)	3.98677765
27	purine nucleobase biosynthetic process (GO:0009113)	3.94126452
28	cytidine catabolic process (GO:0006216)	3.93867167
29	cytidine deamination (GO:0009972)	3.93867167
30	cytidine metabolic process (GO:0046087)	3.93867167
31	deoxyribose phosphate biosynthetic process (GO:0046385)	3.93392300
32	2-deoxyribonucleotide biosynthetic process (GO:0009265)	3.93392300
33	epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)	3.93264208
34	DNA damage induced protein phosphorylation (GO:0006975)	3.85044613
35	regulation of sequestering of triglyceride (GO:0010889)	3.83047345
36	regulation of oxidative phosphorylation (GO:0002082)	3.70955865
37	microtubule nucleation (GO:0007020)	3.69104905
38	quinone biosynthetic process (GO:1901663)	3.69069635
39	leukotriene biosynthetic process (GO:0019370)	3.68634846
40	ubiquinone metabolic process (GO:0006743)	3.63059223
41	tetrahydrofolate metabolic process (GO:0046653)	3.62372093
42	positive regulation of endothelial cell differentiation (GO:0045603)	3.60912594
43	DNA deamination (GO:0045006)	3.60886845
44	pathway-restricted SMAD protein phosphorylation (GO:0060389)	3.59939780
45	folic acid-containing compound metabolic process (GO:0006760)	3.58730829
46	receptor guanylyl cyclase signaling pathway (GO:0007168)	3.57252344
47	energy homeostasis (GO:0097009)	3.52896373
48	photoreceptor cell differentiation (GO:0046530)	3.47218105
49	eye photoreceptor cell differentiation (GO:0001754)	3.47218105
50	tRNA modification (GO:0006400)	3.38185579
51	thrombin receptor signaling pathway (GO:0070493)	3.37649235
52	pyrimidine ribonucleoside catabolic process (GO:0046133)	3.34025206
53	inner ear receptor cell development (GO:0060119)	3.32295459
54	platelet dense granule organization (GO:0060155)	3.30918555
55	negative regulation of DNA biosynthetic process (GO:2000279)	3.25621271
56	purinergic nucleotide receptor signaling pathway (GO:0035590)	3.24937297
57	negative regulation of cAMP-mediated signaling (GO:0043951)	3.22460912
58	alternative mRNA splicing, via spliceosome (GO:0000380)	3.21506823
59	serine family amino acid biosynthetic process (GO:0009070)	3.20466144
60	positive regulation of granulocyte differentiation (GO:0030854)	3.17423259
61	nucleobase biosynthetic process (GO:0046112)	3.14798634
62	regulation of cellular respiration (GO:0043457)	3.11241624
63	negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)	3.07779157
64	organic cation transport (GO:0015695)	3.05972171
65	galactose catabolic process (GO:0019388)	3.05206235
66	cartilage morphogenesis (GO:0060536)	3.04052635
67	white fat cell differentiation (GO:0050872)	3.03382290
68	regulation of gonadotropin secretion (GO:0032276)	3.03143287
69	aminoglycoside antibiotic metabolic process (GO:0030647)	2.98546211
70	response to pheromone (GO:0019236)	2.97833060
71	interleukin-6-mediated signaling pathway (GO:0070102)	2.96419181
72	embryonic skeletal joint morphogenesis (GO:0060272)	2.88449880
73	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.86974661
74	regulation of vitamin D biosynthetic process (GO:0060556)	2.84809991
75	regulation of endothelial cell differentiation (GO:0045601)	2.84458410
76	regulation of hydrogen peroxide metabolic process (GO:0010310)	2.82500383
77	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	2.80120179
78	G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)	2.79937743
79	positive regulation of T cell apoptotic process (GO:0070234)	2.79501747
80	I-kappaB phosphorylation (GO:0007252)	2.78687263
81	purine nucleobase metabolic process (GO:0006144)	2.77747202
82	DNA dealkylation (GO:0035510)	2.75818942
83	DNA strand renaturation (GO:0000733)	2.75733277
84	DNA demethylation (GO:0080111)	2.73931051
85	tRNA processing (GO:0008033)	2.70824978
86	pteridine-containing compound metabolic process (GO:0042558)	2.68882282
87	sulfur amino acid biosynthetic process (GO:0000097)	2.68417250
88	positive regulation of gamma-delta T cell activation (GO:0046645)	2.66462949
89	maturation of SSU-rRNA (GO:0030490)	2.64483569
90	negative regulation of cell cycle arrest (GO:0071157)	2.64482554
91	hepatocyte apoptotic process (GO:0097284)	2.61418861
92	NAD biosynthetic process (GO:0009435)	2.59626015
93	negative regulation of membrane potential (GO:0045837)	2.59604500
94	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	2.59364382
95	galactose metabolic process (GO:0006012)	2.59184756
96	regulation of gamma-delta T cell differentiation (GO:0045586)	2.56276518
97	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.55364171
98	NADH dehydrogenase complex assembly (GO:0010257)	2.55364171
99	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.55364171
100	polyamine biosynthetic process (GO:0006596)	2.54729373

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	9.60320031
2	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	5.92909387
3	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	5.35429559
4	IRF8_22096565_ChIP-ChIP_GC-B_Human	3.69569677
5	VDR_22108803_ChIP-Seq_LS180_Human	3.03796756
6	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.53615308
7	SCL_19346495_ChIP-Seq_HPC-7_Human	2.40778651
8	E2F7_22180533_ChIP-Seq_HELA_Human	2.33968006
9	ZNF274_21170338_ChIP-Seq_K562_Hela	2.29579267
10	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	2.21830388
11	MYB_26560356_Chip-Seq_TH2_Human	1.98835420
12	GATA2_20887958_ChIP-Seq_HPC-7_Mouse	1.86411761
13	TP53_22573176_ChIP-Seq_HFKS_Human	1.85864543
14	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.84215527
15	LMO2_20887958_ChIP-Seq_HPC-7_Mouse	1.80081204
16	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.69271815
17	BCOR_27268052_Chip-Seq_Bcells_Human	1.49793259
18	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.49117368
19	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.45435631
20	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.44641088
21	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.44595709
22	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.44337830
23	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.40552539
24	MYC_19829295_ChIP-Seq_ESCs_Human	1.36886379
25	MECOM_23826213_ChIP-Seq_KASUMI_Mouse	1.36853753
26	OCT4_20526341_ChIP-Seq_ESCs_Human	1.35754193
27	NCOR_22424771_ChIP-Seq_293T_Human	1.32829166
28	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.32466214
29	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	1.32458961
30	P300_27268052_Chip-Seq_Bcells_Human	1.29763227
31	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.27715194
32	STAT1_20625510_ChIP-Seq_HELA_Human	1.26839337
33	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.23747225
34	GATA3_26560356_Chip-Seq_TH2_Human	1.20700731
35	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.19769119
36	NANOG_20526341_ChIP-Seq_ESCs_Human	1.19322339
37	MEIS1_20887958_ChIP-Seq_HPC-7_Mouse	1.18484275
38	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.18393260
39	FOXH1_21741376_ChIP-Seq_ESCs_Human	1.16716181
40	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.16548780
41	CTCF_20526341_ChIP-Seq_ESCs_Human	1.15647233
42	FOXP3_21729870_ChIP-Seq_TREG_Human	1.15432995
43	BCL6_27268052_Chip-Seq_Bcells_Human	1.13688699
44	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.11804446
45	E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human	1.11476293
46	FLI1_21867929_ChIP-Seq_CD8_Mouse	1.09910950
47	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.09771544
48	NANOG_19829295_ChIP-Seq_ESCs_Human	1.08920241
49	SOX2_19829295_ChIP-Seq_ESCs_Human	1.08920241
50	SPI1_23547873_ChIP-Seq_NB4_Human	1.08775246
51	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.08231112
52	SMRT_27268052_Chip-Seq_Bcells_Human	1.08200795
53	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.07563855
54	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.05701645
55	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.05176148
56	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.04789103
57	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.03582718
58	VDR_23849224_ChIP-Seq_CD4+_Human	1.03296241
59	CDX2_22108803_ChIP-Seq_LS180_Human	1.02419819
60	TAF2_19829295_ChIP-Seq_ESCs_Human	1.02231506
61	ERG_20517297_ChIP-Seq_VCAP_Human	1.01885675
62	RUNX_20019798_ChIP-Seq_JUKART_Human	1.01872835
63	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.01302929
64	MAF_26560356_Chip-Seq_TH2_Human	1.01255410
65	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.99353391
66	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.99099141
67	GATA3_21867929_ChIP-Seq_CD8_Mouse	0.97785297
68	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	0.97757955
69	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.96183051
70	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.96183051
71	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	0.95879683
72	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.95745412
73	PCGF2_27294783_Chip-Seq_ESCs_Mouse	0.95205383
74	RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.94642806
75	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	0.94361994
76	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.94174942
77	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	0.92845368
78	GATA1_19941826_ChIP-Seq_K562_Human	0.91350971
79	E2F1_20622854_ChIP-Seq_HELA_Human	0.90270577
80	ERA_21632823_ChIP-Seq_H3396_Human	0.89852881
81	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.89180076
82	RUNX2_22187159_ChIP-Seq_PCA_Human	0.88433310
83	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	0.87886239
84	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	0.87090832
85	RAD21_21589869_ChIP-Seq_MESCs_Mouse	0.86999513
86	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	0.86922733
87	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.86815833
88	SOX3_22085726_ChIP-Seq_MUSCLE_Mouse	0.86771706
89	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.86767790
90	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.85890556
91	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.85798352
92	AR_20517297_ChIP-Seq_VCAP_Human	0.84529468
93	GATA3_27048872_Chip-Seq_THYMUS_Human	0.84225227
94	GBX2_23144817_ChIP-Seq_PC3_Human	0.83905678
95	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.83832918
96	GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.83219143
97	MYB_26560356_Chip-Seq_TH1_Human	0.82758779
98	CIITA_25753668_ChIP-Seq_RAJI_Human	0.82671659
99	BCAT_22108803_ChIP-Seq_LS180_Human	0.82579643
100	SPI1_20517297_ChIP-Seq_HL60_Human	0.80934520

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005360_urolithiasis	6.11590470
2	MP0003806_abnormal_nucleotide_metabolis	4.92758921
3	MP0003183_abnormal_peptide_metabolism	3.92812358
4	MP0005377_hearing/vestibular/ear_phenot	3.23754203
5	MP0003878_abnormal_ear_physiology	3.23754203
6	MP0005646_abnormal_pituitary_gland	2.97894368
7	MP0004147_increased_porphyrin_level	2.67811036
8	MP0002277_abnormal_respiratory_mucosa	2.51610038
9	MP0002396_abnormal_hematopoietic_system	2.40122888
10	MP0001346_abnormal_lacrimal_gland	2.27516721
11	MP0002160_abnormal_reproductive_system	2.25519871
12	MP0008995_early_reproductive_senescence	2.14858631
13	MP0001661_extended_life_span	1.90785521
14	MP0008775_abnormal_heart_ventricle	1.87937026
15	MP0004043_abnormal_pH_regulation	1.87095307
16	MP0000647_abnormal_sebaceous_gland	1.87032730
17	MP0002095_abnormal_skin_pigmentation	1.86701276
18	MP0008872_abnormal_physiological_respon	1.85294226
19	MP0003724_increased_susceptibility_to	1.81623454
20	MP0001764_abnormal_homeostasis	1.72710959
21	MP0005389_reproductive_system_phenotype	1.67067795
22	MP0005670_abnormal_white_adipose	1.66006203
23	MP0003705_abnormal_hypodermis_morpholog	1.61020155
24	MP0005671_abnormal_response_to	1.59532521
25	MP0005332_abnormal_amino_acid	1.59019046
26	MP0000026_abnormal_inner_ear	1.53006198
27	MP0008877_abnormal_DNA_methylation	1.43196165
28	MP0002736_abnormal_nociception_after	1.40811486
29	MP0001963_abnormal_hearing_physiology	1.38614628
30	MP0001853_heart_inflammation	1.36078763
31	MP0003567_abnormal_fetal_cardiomyocyte	1.33728060
32	MP0001986_abnormal_taste_sensitivity	1.33618991
33	MP0003646_muscle_fatigue	1.32762367
34	MP0005551_abnormal_eye_electrophysiolog	1.32135086
35	MP0002009_preneoplasia	1.27783253
36	MP0001851_eye_inflammation	1.27604604
37	MP0005410_abnormal_fertilization	1.26093099
38	MP0001800_abnormal_humoral_immune	1.24224122
39	MP0002006_tumorigenesis	1.23574550
40	MP0001756_abnormal_urination	1.20841838
41	MP0003693_abnormal_embryo_hatching	1.20703449
42	MP0002148_abnormal_hypersensitivity_rea	1.20291794
43	MP0001485_abnormal_pinna_reflex	1.16396279
44	MP0000383_abnormal_hair_follicle	1.14396327
45	MP0008875_abnormal_xenobiotic_pharmacok	1.13794480
46	MP0000013_abnormal_adipose_tissue	1.12356810
47	MP0004036_abnormal_muscle_relaxation	1.09474884
48	MP0009250_abnormal_appendicular_skeleto	1.09188690
49	MP0004885_abnormal_endolymph	1.08015230
50	MP0009764_decreased_sensitivity_to	1.05883475
51	MP0002132_abnormal_respiratory_system	1.05737864
52	MP0002163_abnormal_gland_morphology	1.04235324
53	MP0001968_abnormal_touch/_nociception	1.00778405
54	MP0005075_abnormal_melanosome_morpholog	1.00136045
55	MP0009643_abnormal_urine_homeostasis	0.96222506
56	MP0005376_homeostasis/metabolism_phenot	0.93962599
57	MP0006036_abnormal_mitochondrial_physio	0.93600135
58	MP0002452_abnormal_antigen_presenting	0.92263502
59	MP0002102_abnormal_ear_morphology	0.92113468
60	MP0002638_abnormal_pupillary_reflex	0.90679092
61	MP0009765_abnormal_xenobiotic_induced	0.88957638
62	MP0009333_abnormal_splenocyte_physiolog	0.88467752
63	MP0002933_joint_inflammation	0.86516619
64	MP0002420_abnormal_adaptive_immunity	0.86423938
65	MP0002419_abnormal_innate_immunity	0.85474231
66	MP0001819_abnormal_immune_cell	0.84526390
67	MP0002723_abnormal_immune_serum	0.84373324
68	MP0005636_abnormal_mineral_homeostasis	0.83631889
69	MP0003880_abnormal_central_pattern	0.81790281
70	MP0000230_abnormal_systemic_arterial	0.81480099
71	MP0005595_abnormal_vascular_smooth	0.81028613
72	MP0005645_abnormal_hypothalamus_physiol	0.80810193
73	MP0002127_abnormal_cardiovascular_syste	0.79874515
74	MP0002735_abnormal_chemical_nociception	0.79567514
75	MP0005164_abnormal_response_to	0.79510374
76	MP0001765_abnormal_ion_homeostasis	0.78605328
77	MP0002398_abnormal_bone_marrow	0.78240823
78	MP0005584_abnormal_enzyme/coenzyme_acti	0.77980299
79	MP0010094_abnormal_chromosome_stability	0.77943908
80	MP0005248_abnormal_Harderian_gland	0.77909502
81	MP0004019_abnormal_vitamin_homeostasis	0.77678756
82	MP0001340_abnormal_eyelid_morphology	0.75905183
83	MP0005000_abnormal_immune_tolerance	0.75532013
84	MP0001919_abnormal_reproductive_system	0.75297525
85	MP0002429_abnormal_blood_cell	0.72939457
86	MP0005266_abnormal_metabolism	0.72892906
87	MP0000716_abnormal_immune_system	0.72620806
88	MP0002229_neurodegeneration	0.72132320
89	MP0000678_abnormal_parathyroid_gland	0.71971027
90	MP0003186_abnormal_redox_activity	0.71698122
91	MP0004084_abnormal_cardiac_muscle	0.71403287
92	MP0002733_abnormal_thermal_nociception	0.69499027
93	MP0000733_abnormal_muscle_development	0.69464661
94	MP0002971_abnormal_brown_adipose	0.68462848
95	MP0000681_abnormal_thyroid_gland	0.68192262
96	MP0002138_abnormal_hepatobiliary_system	0.68167173
97	MP0008469_abnormal_protein_level	0.67921507
98	MP0006276_abnormal_autonomic_nervous	0.67808951
99	MP0001835_abnormal_antigen_presentation	0.66805653
100	MP0003252_abnormal_bile_duct	0.66306814

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of alanine metabolism (HP:0010916)	6.70751087
2	Hyperalaninemia (HP:0003348)	6.70751087
3	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	6.70751087
4	Constricted visual fields (HP:0001133)	5.86927777
5	Cone-rod dystrophy (HP:0000548)	4.63706060
6	Spontaneous hematomas (HP:0007420)	4.03962732
7	Conjugated hyperbilirubinemia (HP:0002908)	4.00649306
8	Renal cortical cysts (HP:0000803)	3.62604157
9	Agammaglobulinemia (HP:0004432)	3.48634125
10	Hypomagnesemia (HP:0002917)	3.48587962
11	Congenital sensorineural hearing impairment (HP:0008527)	3.48132165
12	Tetany (HP:0001281)	3.44872022
13	Unilateral renal agenesis (HP:0000122)	3.36753342
14	Decreased electroretinogram (ERG) amplitude (HP:0000654)	3.30176514
15	White forelock (HP:0002211)	3.29902645
16	Poor speech (HP:0002465)	3.04378695
17	Abnormality of the fetal cardiovascular system (HP:0010948)	3.03590731
18	Abnormal umbilical cord blood vessels (HP:0011403)	3.03590731
19	Single umbilical artery (HP:0001195)	3.03590731
20	Birth length less than 3rd percentile (HP:0003561)	2.97919180
21	Recurrent corneal erosions (HP:0000495)	2.93757535
22	Esophageal varix (HP:0002040)	2.93040462
23	Chronic otitis media (HP:0000389)	2.91813717
24	Pigmentary retinal degeneration (HP:0001146)	2.89124498
25	Patchy hypopigmentation of hair (HP:0011365)	2.85370502
26	Attenuation of retinal blood vessels (HP:0007843)	2.75746187
27	Cortical visual impairment (HP:0100704)	2.73019636
28	Parakeratosis (HP:0001036)	2.71450459
29	Anorexia (HP:0002039)	2.68173124
30	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	2.66292515
31	Elevated erythrocyte sedimentation rate (HP:0003565)	2.65574099
32	Duplicated collecting system (HP:0000081)	2.65131713
33	Chronic diarrhea (HP:0002028)	2.64014479
34	Abnormality of magnesium homeostasis (HP:0004921)	2.61322861
35	Arterial thrombosis (HP:0004420)	2.58606037
36	Abnormality of dental color (HP:0011073)	2.58335951
37	Abnormality of the renal collecting system (HP:0004742)	2.58322721
38	Homocystinuria (HP:0002156)	2.58081970
39	Abnormality of homocysteine metabolism (HP:0010919)	2.58081970
40	Ureteral duplication (HP:0000073)	2.53351265
41	Panhypogammaglobulinemia (HP:0003139)	2.52828997
42	Abnormality of sulfur amino acid metabolism (HP:0004339)	2.50839004
43	Gingival bleeding (HP:0000225)	2.50407371
44	Conjunctival telangiectasia (HP:0000524)	2.50328388
45	Cerebellar dysplasia (HP:0007033)	2.46403136
46	Toxemia of pregnancy (HP:0100603)	2.40406560
47	Pulmonary embolism (HP:0002204)	2.35448830
48	Abnormality of serum amino acid levels (HP:0003112)	2.35055638
49	Megaloblastic anemia (HP:0001889)	2.32782094
50	Chromsome breakage (HP:0040012)	2.30278146
51	Molar tooth sign on MRI (HP:0002419)	2.24578515
52	Abnormality of midbrain morphology (HP:0002418)	2.24578515
53	Thrombophlebitis (HP:0004418)	2.23827501
54	Hypertensive crisis (HP:0100735)	2.22543291
55	Cheilitis (HP:0100825)	2.20131066
56	Brushfield spots (HP:0001088)	2.18687414
57	Visual hallucinations (HP:0002367)	2.17586612
58	Abnormality of the vasculature of the conjunctiva (HP:0008054)	2.14975371
59	Myositis (HP:0100614)	2.12084346
60	Epistaxis (HP:0000421)	2.09432938
61	Generalized aminoaciduria (HP:0002909)	2.07964322
62	Type I diabetes mellitus (HP:0100651)	2.05538353
63	Long clavicles (HP:0000890)	2.05159488
64	Nausea (HP:0002018)	2.02475591
65	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.02150756
66	Abolished electroretinogram (ERG) (HP:0000550)	2.01285662
67	Mesangial abnormality (HP:0001966)	1.99824054
68	Petechiae (HP:0000967)	1.98541164
69	Widely patent fontanelles and sutures (HP:0004492)	1.97354929
70	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.96284179
71	Alopecia of scalp (HP:0002293)	1.93778257
72	Fatigue (HP:0012378)	1.92879837
73	Urticaria (HP:0001025)	1.91970899
74	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.91618929
75	Anomalous pulmonary venous return (HP:0010772)	1.90116217
76	Abnormality of fatty-acid metabolism (HP:0004359)	1.82914128
77	Abnormality of the renal cortex (HP:0011035)	1.82827451
78	Metabolic acidosis (HP:0001942)	1.82431870
79	Retinal atrophy (HP:0001105)	1.81899916
80	Prolonged bleeding time (HP:0003010)	1.81039978
81	Dyskinesia (HP:0100660)	1.80856633
82	Follicular hyperkeratosis (HP:0007502)	1.79842027
83	Abnormal rod and cone electroretinograms (HP:0008323)	1.79573583
84	Proximal tubulopathy (HP:0000114)	1.78085504
85	Seborrheic dermatitis (HP:0001051)	1.75317671
86	Cerebral ischemia (HP:0002637)	1.74298408
87	Truncus arteriosus (HP:0001660)	1.72513194
88	Glycosuria (HP:0003076)	1.71003636
89	Abnormality of urine glucose concentration (HP:0011016)	1.71003636
90	Chronic hepatic failure (HP:0100626)	1.70811784
91	Abnormality of methionine metabolism (HP:0010901)	1.64872815
92	Abnormal delayed hypersensitivity skin test (HP:0002963)	1.64711450
93	Nonprogressive disorder (HP:0003680)	1.64271067
94	Decreased central vision (HP:0007663)	1.63625627
95	Increased serum lactate (HP:0002151)	1.63587744
96	Abnormality of the umbilical cord (HP:0010881)	1.61520403
97	Breech presentation (HP:0001623)	1.60314515
98	Decreased subcutaneous fat (HP:0001002)	1.58963540
99	Visceral angiomatosis (HP:0100761)	1.58808762
100	Abnormal biliary tract morphology (HP:0012440)	1.57452426

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP3K13	9.19277134
2	MAP2K3	3.93665130
3	MAP3K14	3.15697102
4	CDK19	2.75640114
5	TXK	2.64962983
6	MAP3K7	2.62139215
7	TAOK3	2.59261756
8	PASK	2.04957860
9	MST4	2.04840376
10	JAK3	2.04223327
11	NTRK2	1.99976634
12	MAP3K3	1.97575523
13	EIF2AK3	1.96241430
14	CDK9	1.79431638
15	MAP4K1	1.79054724
16	TAF1	1.66029441
17	MAP3K11	1.64183363
18	IRAK4	1.56913706
19	IKBKB	1.51163923
20	WNK4	1.49613891
21	KIT	1.45301456
22	RPS6KB2	1.42128098
23	FRK	1.36758278
24	VRK2	1.36479496
25	CAMKK1	1.35673234
26	MAP4K2	1.23140742
27	CCNB1	1.15931158
28	MET	1.10301693
29	GRK1	1.07035571
30	SYK	1.05021213
31	FGR	1.03854970
32	STK16	1.03328653
33	ZAK	0.93887282
34	FLT3	0.92017182
35	DYRK1B	0.91143485
36	PRKCQ	0.88849821
37	ADRBK1	0.88810906
38	ADRBK2	0.81895922
39	TNK2	0.77915939
40	PIM1	0.77550458
41	IRAK1	0.76300339
42	MAP2K6	0.75019908
43	ACVR1B	0.73792158
44	OBSCN	0.72141218
45	IRAK2	0.67285941
46	RPS6KA6	0.67115577
47	WNK1	0.65969464
48	CHUK	0.65293331
49	KDR	0.64554295
50	IKBKE	0.63853158
51	MAP2K4	0.63090862
52	IRAK3	0.62973983
53	MAPKAPK5	0.61568676
54	SMG1	0.59662325
55	PDK2	0.59374560
56	CAMK1	0.59245414
57	BTK	0.56457117
58	TESK2	0.56135959
59	NTRK3	0.53620098
60	CLK1	0.53160469
61	HIPK2	0.53046208
62	PIM2	0.52915253
63	NUAK1	0.52586660
64	SGK223	0.50209659
65	SGK494	0.50209659
66	CDK6	0.49791698
67	EIF2AK2	0.49078200
68	RPS6KC1	0.48316131
69	RPS6KL1	0.48316131
70	ITK	0.47720369
71	TEC	0.47573581
72	GRK6	0.45027312
73	TBK1	0.44711258
74	LYN	0.43889733
75	EPHB2	0.43748434
76	SGK1	0.43400230
77	LCK	0.42584446
78	PRKAA2	0.41030768
79	BLK	0.39657508
80	ABL2	0.39568540
81	CAMKK2	0.38857206
82	ATR	0.37143525
83	MATK	0.36642489
84	MAPK12	0.34732758
85	CAMK4	0.32238340
86	SGK2	0.32089918
87	MAPK13	0.31435908
88	FGFR2	0.30940043
89	PRKD2	0.30439850
90	CHEK2	0.29936990
91	FES	0.28790041
92	MAP3K1	0.28190429
93	SRPK1	0.28101187
94	ARAF	0.25974298
95	PRKCA	0.24925275
96	UHMK1	0.23844875
97	DAPK3	0.22822245
98	CSNK1A1	0.22794996
99	GRK5	0.21838929
100	PLK1	0.20987245

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	One carbon pool by folate_Homo sapiens_hsa00670	5.80796834
2	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	4.34872526
3	Sulfur relay system_Homo sapiens_hsa04122	3.63520998
4	Vitamin digestion and absorption_Homo sapiens_hsa04977	2.98676728
5	Arginine biosynthesis_Homo sapiens_hsa00220	2.95941104
6	Collecting duct acid secretion_Homo sapiens_hsa04966	2.78244287
7	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.62421985
8	Primary immunodeficiency_Homo sapiens_hsa05340	2.34747852
9	Graft-versus-host disease_Homo sapiens_hsa05332	2.10315190
10	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.94944773
11	Ribosome_Homo sapiens_hsa03010	1.93838971
12	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.92315874
13	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.83295380
14	Peroxisome_Homo sapiens_hsa04146	1.76928248
15	Homologous recombination_Homo sapiens_hsa03440	1.56278182
16	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.55682858
17	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.53481225
18	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.51323001
19	Regulation of autophagy_Homo sapiens_hsa04140	1.43006151
20	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.40997913
21	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.37730936
22	Selenocompound metabolism_Homo sapiens_hsa00450	1.34665697
23	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.27941364
24	Taste transduction_Homo sapiens_hsa04742	1.17906201
25	Morphine addiction_Homo sapiens_hsa05032	1.15018746
26	ABC transporters_Homo sapiens_hsa02010	1.13333211
27	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	1.12400482
28	Linoleic acid metabolism_Homo sapiens_hsa00591	1.09281882
29	Folate biosynthesis_Homo sapiens_hsa00790	1.07482751
30	Olfactory transduction_Homo sapiens_hsa04740	1.07407040
31	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.04036148
32	Allograft rejection_Homo sapiens_hsa05330	1.03921307
33	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.99922126
34	Galactose metabolism_Homo sapiens_hsa00052	0.98235186
35	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.97176845
36	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.93486075
37	GABAergic synapse_Homo sapiens_hsa04727	0.90980539
38	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.90877803
39	Nitrogen metabolism_Homo sapiens_hsa00910	0.88159856
40	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.87370285
41	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.87013959
42	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.82948190
43	Caffeine metabolism_Homo sapiens_hsa00232	0.81898372
44	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.81525305
45	Antigen processing and presentation_Homo sapiens_hsa04612	0.78266637
46	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.76378809
47	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.75030204
48	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.73735531
49	Oxidative phosphorylation_Homo sapiens_hsa00190	0.72559058
50	Platelet activation_Homo sapiens_hsa04611	0.70972695
51	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.70878760
52	Other glycan degradation_Homo sapiens_hsa00511	0.70617964
53	Serotonergic synapse_Homo sapiens_hsa04726	0.70372619
54	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.70278747
55	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.70195241
56	Basal transcription factors_Homo sapiens_hsa03022	0.70096747
57	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.68451059
58	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.67975254
59	Osteoclast differentiation_Homo sapiens_hsa04380	0.67662619
60	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.66999304
61	Asthma_Homo sapiens_hsa05310	0.66759322
62	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.63730988
63	Ether lipid metabolism_Homo sapiens_hsa00565	0.61941822
64	Purine metabolism_Homo sapiens_hsa00230	0.61731037
65	Chemokine signaling pathway_Homo sapiens_hsa04062	0.60006488
66	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.58993618
67	Rheumatoid arthritis_Homo sapiens_hsa05323	0.58395274
68	Circadian entrainment_Homo sapiens_hsa04713	0.54899392
69	Retinol metabolism_Homo sapiens_hsa00830	0.54660790
70	Spliceosome_Homo sapiens_hsa03040	0.53846451
71	Tryptophan metabolism_Homo sapiens_hsa00380	0.53751622
72	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.52993363
73	TNF signaling pathway_Homo sapiens_hsa04668	0.52976846
74	Nicotine addiction_Homo sapiens_hsa05033	0.52713201
75	RNA transport_Homo sapiens_hsa03013	0.52579937
76	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.51783165
77	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.51669430
78	Type I diabetes mellitus_Homo sapiens_hsa04940	0.50954481
79	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.48192672
80	Type II diabetes mellitus_Homo sapiens_hsa04930	0.47641503
81	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.47275926
82	Metabolic pathways_Homo sapiens_hsa01100	0.43174174
83	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.42337160
84	African trypanosomiasis_Homo sapiens_hsa05143	0.41450936
85	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.41361500
86	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.41288588
87	mRNA surveillance pathway_Homo sapiens_hsa03015	0.40733293
88	Non-homologous end-joining_Homo sapiens_hsa03450	0.38782631
89	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.37587578
90	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.37495284
91	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.36836406
92	Acute myeloid leukemia_Homo sapiens_hsa05221	0.35107450
93	Phototransduction_Homo sapiens_hsa04744	0.34842652
94	Shigellosis_Homo sapiens_hsa05131	0.34688745
95	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.33883829
96	Salivary secretion_Homo sapiens_hsa04970	0.33679879
97	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.33158463
98	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.32111459
99	Glutamatergic synapse_Homo sapiens_hsa04724	0.31866915
100	Malaria_Homo sapiens_hsa05144	0.31549349

ABHD17AP4

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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