ABHD17AP5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine-containing compound transmembrane transport (GO:0072531)7.80530040
2purinergic nucleotide receptor signaling pathway (GO:0035590)5.04636429
3defense response to protozoan (GO:0042832)4.97308157
4positive regulation of B cell differentiation (GO:0045579)4.87483218
5vitamin transmembrane transport (GO:0035461)4.84984750
6purine nucleotide salvage (GO:0032261)4.79385940
7G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)4.75911040
8positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.60236768
9response to protozoan (GO:0001562)4.53202806
10positive regulation of granulocyte differentiation (GO:0030854)4.53135279
11definitive hemopoiesis (GO:0060216)4.53081178
12B cell receptor signaling pathway (GO:0050853)4.31989175
13immunoglobulin mediated immune response (GO:0016064)4.27813458
14regulation of B cell differentiation (GO:0045577)4.24782441
15regulation of B cell receptor signaling pathway (GO:0050855)4.22486577
16positive regulation of gamma-delta T cell activation (GO:0046645)4.17483605
17regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.06013074
18DNA damage induced protein phosphorylation (GO:0006975)4.02029683
19purinergic receptor signaling pathway (GO:0035587)3.83737428
20nucleoside transmembrane transport (GO:1901642)3.82837591
212-deoxyribonucleotide biosynthetic process (GO:0009265)3.67934528
22deoxyribose phosphate biosynthetic process (GO:0046385)3.67934528
23adenosine metabolic process (GO:0046085)3.66680233
24neutrophil activation involved in immune response (GO:0002283)3.62956941
25B cell mediated immunity (GO:0019724)3.58775985
26Peyers patch development (GO:0048541)3.58675651
27mucosal-associated lymphoid tissue development (GO:0048537)3.58675651
28mitochondrial calcium ion transport (GO:0006851)3.57079105
29response to peptidoglycan (GO:0032494)3.56458534
30Arp2/3 complex-mediated actin nucleation (GO:0034314)3.52952665
31antigen processing and presentation of endogenous antigen (GO:0019883)3.50013135
32negative regulation of B cell apoptotic process (GO:0002903)3.48336116
33pinocytosis (GO:0006907)3.47929593
34purine-containing compound salvage (GO:0043101)3.40812780
35purine nucleobase biosynthetic process (GO:0009113)3.38879301
36histamine secretion (GO:0001821)3.35315916
37regulation of penile erection (GO:0060405)3.34270716
38thrombin receptor signaling pathway (GO:0070493)3.33980769
39regulation of granulocyte differentiation (GO:0030852)3.29096906
40regulation of B cell apoptotic process (GO:0002902)3.27484842
41negative regulation of thymocyte apoptotic process (GO:0070244)3.18879159
42pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.16472010
43platelet dense granule organization (GO:0060155)3.12143902
44azole transport (GO:0045117)3.11115430
45I-kappaB phosphorylation (GO:0007252)3.10195759
46B cell homeostasis (GO:0001782)3.05538789
47nucleotide salvage (GO:0043173)3.05483711
48G-protein coupled purinergic receptor signaling pathway (GO:0035588)3.05334560
49regulation of antigen processing and presentation (GO:0002577)3.04968259
50deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.99211752
51pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.95654421
52autophagic vacuole fusion (GO:0000046)2.92455009
53modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.92210252
54positive regulation by organism of defense response of other organism involved in symbiotic interact2.92210252
55modulation by symbiont of host immune response (GO:0052553)2.92210252
56positive regulation by symbiont of host defense response (GO:0052509)2.92210252
57modulation by symbiont of host defense response (GO:0052031)2.92210252
58modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.92210252
59positive thymic T cell selection (GO:0045059)2.91751682
60regulation of thymocyte apoptotic process (GO:0070243)2.90171528
61negative thymic T cell selection (GO:0045060)2.90063388
62regulation of germinal center formation (GO:0002634)2.89604570
63regulation of gamma-delta T cell activation (GO:0046643)2.88618847
64regulation of gamma-delta T cell differentiation (GO:0045586)2.87814154
65folic acid transport (GO:0015884)2.87796135
66antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.87561102
67mature B cell differentiation involved in immune response (GO:0002313)2.85196020
68actin nucleation (GO:0045010)2.85060982
69detection of bacterium (GO:0016045)2.82827537
70neutrophil activation (GO:0042119)2.82674740
71angiogenesis involved in wound healing (GO:0060055)2.79504683
72response to muramyl dipeptide (GO:0032495)2.79112968
73mast cell activation involved in immune response (GO:0002279)2.78761984
74mast cell degranulation (GO:0043303)2.78761984
75antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.75389259
76mast cell activation (GO:0045576)2.75028967
77nucleobase biosynthetic process (GO:0046112)2.74986305
78positive regulation of B cell activation (GO:0050871)2.73876216
79lymphocyte homeostasis (GO:0002260)2.72515856
80regulation of dendritic cell antigen processing and presentation (GO:0002604)2.72122976
81nucleoside transport (GO:0015858)2.71092233
82positive regulation of antigen processing and presentation (GO:0002579)2.70983360
83thymic T cell selection (GO:0045061)2.70730897
84response to host immune response (GO:0052572)2.69642622
85response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.69642622
86negative T cell selection (GO:0043383)2.68892998
87regulation of Golgi to plasma membrane protein transport (GO:0042996)2.68787910
88positive regulation of mast cell activation (GO:0033005)2.68204877
89pyrimidine nucleotide catabolic process (GO:0006244)2.67968957
90negative regulation of growth of symbiont in host (GO:0044130)2.66877533
91negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.66877533
92modulation of growth of symbiont involved in interaction with host (GO:0044144)2.66877533
93regulation of growth of symbiont in host (GO:0044126)2.66877533
94positive regulation of mast cell degranulation (GO:0043306)2.64850810
95positive regulation of mast cell activation involved in immune response (GO:0033008)2.64850810
96kinetochore assembly (GO:0051382)2.64593867
97deoxyribonucleotide catabolic process (GO:0009264)2.62896484
98negative regulation of erythrocyte differentiation (GO:0045647)2.62755791
99leukocyte aggregation (GO:0070486)2.60880270
100detection of other organism (GO:0098543)2.60823553

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.56713305
2SCL_19346495_ChIP-Seq_HPC-7_Human4.74483925
3E2F7_22180533_ChIP-Seq_HELA_Human4.38086877
4MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.30729233
5RUNX1_20887958_ChIP-Seq_HPC-7_Mouse3.21542919
6SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.00446717
7VDR_21846776_ChIP-Seq_THP-1_Human2.97494322
8MYC_22102868_ChIP-Seq_BL_Human2.92723818
9LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.86677228
10ELF1_17652178_ChIP-ChIP_JURKAT_Human2.86341641
11MYB_26560356_Chip-Seq_TH2_Human2.69386876
12E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.56173520
13LMO2_20887958_ChIP-Seq_HPC-7_Mouse2.56004119
14RUNX_20019798_ChIP-Seq_JUKART_Human2.54726890
15IRF8_21731497_ChIP-ChIP_J774_Mouse2.51466643
16SPI1_23547873_ChIP-Seq_NB4_Human2.45434256
17VDR_24763502_ChIP-Seq_THP-1_Human2.37918171
18SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.37177829
19STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.35571245
20VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.35510894
21IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.28111137
22UTX_26944678_Chip-Seq_JUKART_Human2.27809780
23GATA2_20887958_ChIP-Seq_HPC-7_Mouse2.16375624
24CIITA_25753668_ChIP-Seq_RAJI_Human2.16098437
25SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.15399200
26IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.10883328
27SPI1_23127762_ChIP-Seq_K562_Human1.97205230
28MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.95634669
29ELF1_20517297_ChIP-Seq_JURKAT_Human1.95614636
30IRF8_27001747_Chip-Seq_BMDM_Mouse1.93012567
31SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.92089996
32TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.90384750
33IKZF1_21737484_ChIP-ChIP_HCT116_Human1.88481362
34RUNX1_22412390_ChIP-Seq_EML_Mouse1.81337157
35MAF_26560356_Chip-Seq_TH1_Human1.78685499
36MYB_26560356_Chip-Seq_TH1_Human1.76353999
37SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.76209096
38GATA1_19941826_ChIP-Seq_K562_Human1.75666437
39FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.72169422
40BCOR_27268052_Chip-Seq_Bcells_Human1.65342502
41MAF_26560356_Chip-Seq_TH2_Human1.64693364
42GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.63278610
43ZNF274_21170338_ChIP-Seq_K562_Hela1.59585520
44STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.52431567
45GATA1_19941827_ChIP-Seq_MEL_Mouse1.51753673
46GATA3_27048872_Chip-Seq_THYMUS_Human1.51037853
47VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.50550858
48BCL6_27268052_Chip-Seq_Bcells_Human1.49442768
49FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.47753370
50P300_27268052_Chip-Seq_Bcells_Human1.44637249
51CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.43616804
52GATA3_26560356_Chip-Seq_TH2_Human1.42732925
53PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.40731179
54KDM2B_26808549_Chip-Seq_DND41_Human1.40115644
55MYB_21317192_ChIP-Seq_ERMYB_Mouse1.39545241
56SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.38455340
57TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.36145329
58KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.32833397
59SPI1_20517297_ChIP-Seq_HL60_Human1.32670901
60SRY_22984422_ChIP-ChIP_TESTIS_Rat1.28255159
61KDM2B_26808549_Chip-Seq_SUP-B15_Human1.28223577
62NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.27704097
63BRD4_27068464_Chip-Seq_AML-cells_Mouse1.26824521
64GATA2_22383799_ChIP-Seq_G1ME_Mouse1.25702529
65E2F1_20622854_ChIP-Seq_HELA_Human1.24785759
66TCF7_22412390_ChIP-Seq_EML_Mouse1.23805128
67CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.23069895
68KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.21286172
69GATA1_22383799_ChIP-Seq_G1ME_Mouse1.20880167
70STAT4_19710469_ChIP-ChIP_TH1__Mouse1.20803602
71FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.20056093
72YY1_22570637_ChIP-Seq_MALME-3M_Human1.16037855
73ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.12973696
74SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human1.11981803
75NANOG_20526341_ChIP-Seq_ESCs_Human1.10356511
76SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.05840595
77PU.1_20513432_ChIP-Seq_Bcells_Mouse1.02884187
78P68_20966046_ChIP-Seq_HELA_Human0.99957477
79ERG_20887958_ChIP-Seq_HPC-7_Mouse0.99149824
80RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98032911
81FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.97520071
82PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95718481
83SMRT_27268052_Chip-Seq_Bcells_Human0.94590040
84GATA2_21666600_ChIP-Seq_HMVEC_Human0.94257196
85PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.94055576
86TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.93577245
87THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.93167491
88BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.92463571
89RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.91668337
90CTCF_21964334_ChIP-Seq_BJAB-B_Human0.89963624
91EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.89101089
92LXR_22292898_ChIP-Seq_THP-1_Human0.87040553
93VDR_24787735_ChIP-Seq_THP-1_Human0.86962588
94CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.86780734
95MYC_19829295_ChIP-Seq_ESCs_Human0.85929291
96VDR_23849224_ChIP-Seq_CD4+_Human0.85292397
97TP63_22573176_ChIP-Seq_HFKS_Human0.85136391
98NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.85059004
99GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.84350810
100TP53_22573176_ChIP-Seq_HFKS_Human0.84312815

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005464_abnormal_platelet_physiology3.98231068
2MP0001835_abnormal_antigen_presentation3.60924802
3MP0005671_abnormal_response_to2.97909448
4MP0001346_abnormal_lacrimal_gland2.91357123
5MP0009278_abnormal_bone_marrow2.89893816
6MP0001800_abnormal_humoral_immune2.83822385
7MP0002148_abnormal_hypersensitivity_rea2.82716530
8MP0000685_abnormal_immune_system2.57923570
9MP0001790_abnormal_immune_system2.55474058
10MP0005387_immune_system_phenotype2.55474058
11MP0003806_abnormal_nucleotide_metabolis2.54567708
12MP0005360_urolithiasis2.51414528
13MP0002452_abnormal_antigen_presenting2.41987699
14MP0002277_abnormal_respiratory_mucosa2.39149432
15MP0002396_abnormal_hematopoietic_system2.37450379
16MP0002420_abnormal_adaptive_immunity2.30784870
17MP0001819_abnormal_immune_cell2.26216301
18MP0002723_abnormal_immune_serum2.24884048
19MP0002398_abnormal_bone_marrow2.21381285
20MP0002419_abnormal_innate_immunity2.21144580
21MP0005000_abnormal_immune_tolerance2.19533029
22MP0003436_decreased_susceptibility_to2.12205305
23MP0001545_abnormal_hematopoietic_system2.01918292
24MP0005397_hematopoietic_system_phenotyp2.01918292
25MP0009764_decreased_sensitivity_to1.95509868
26MP0003763_abnormal_thymus_physiology1.93508604
27MP0005025_abnormal_response_to1.91911656
28MP0000716_abnormal_immune_system1.91679512
29MP0003172_abnormal_lysosome_physiology1.89843551
30MP0010155_abnormal_intestine_physiology1.88916910
31MP0003303_peritoneal_inflammation1.81954115
32MP0000689_abnormal_spleen_morphology1.81412390
33MP0002429_abnormal_blood_cell1.73623634
34MP0005075_abnormal_melanosome_morpholog1.69528538
35MP0001851_eye_inflammation1.66680563
36MP0002722_abnormal_immune_system1.58482988
37MP0008877_abnormal_DNA_methylation1.57195604
38MP0003724_increased_susceptibility_to1.57030901
39MP0000465_gastrointestinal_hemorrhage1.57018032
40MP0009785_altered_susceptibility_to1.56909941
41MP0001853_heart_inflammation1.56475093
42MP0001873_stomach_inflammation1.49938810
43MP0002405_respiratory_system_inflammati1.45784616
44MP0004947_skin_inflammation1.38609797
45MP0000372_irregular_coat_pigmentation1.37772220
46MP0002006_tumorigenesis1.37470316
47MP0003191_abnormal_cellular_cholesterol1.34955685
48MP0002166_altered_tumor_susceptibility1.28774295
49MP0000383_abnormal_hair_follicle1.28231998
50MP0008775_abnormal_heart_ventricle1.21489627
51MP0010094_abnormal_chromosome_stability1.20982180
52MP0009333_abnormal_splenocyte_physiolog1.19361787
53MP0000703_abnormal_thymus_morphology1.18270954
54MP0008469_abnormal_protein_level1.15995859
55MP0005084_abnormal_gallbladder_morpholo1.14836070
56MP0002019_abnormal_tumor_incidence1.11478789
57MP0001845_abnormal_inflammatory_respons1.10406221
58MP0000490_abnormal_crypts_of1.09799948
59MP0002095_abnormal_skin_pigmentation1.06517389
60MP0009697_abnormal_copulation1.04805049
61MP0003638_abnormal_response/metabolism_1.02179897
62MP0001663_abnormal_digestive_system1.00776827
63MP0009765_abnormal_xenobiotic_induced1.00157160
64MP0005451_abnormal_body_composition0.99077635
65MP0004808_abnormal_hematopoietic_stem0.98196685
66MP0001986_abnormal_taste_sensitivity0.97457264
67MP0005389_reproductive_system_phenotype0.93866276
68MP0003300_gastrointestinal_ulcer0.91353540
69MP0002733_abnormal_thermal_nociception0.91291701
70MP0001533_abnormal_skeleton_physiology0.89422291
71MP0001348_abnormal_lacrimal_gland0.88680211
72MP0002735_abnormal_chemical_nociception0.88570887
73MP0002933_joint_inflammation0.88340647
74MP0000681_abnormal_thyroid_gland0.87895503
75MP0004036_abnormal_muscle_relaxation0.86432454
76MP0003252_abnormal_bile_duct0.86094673
77MP0002009_preneoplasia0.86088418
78MP0008872_abnormal_physiological_respon0.86020859
79MP0005584_abnormal_enzyme/coenzyme_acti0.85955003
80MP0000470_abnormal_stomach_morphology0.85854876
81MP0000313_abnormal_cell_death0.80292607
82MP0001764_abnormal_homeostasis0.79193393
83MP0009763_increased_sensitivity_to0.78912326
84MP0003566_abnormal_cell_adhesion0.77095145
85MP0002138_abnormal_hepatobiliary_system0.74629871
86MP0003866_abnormal_defecation0.74272773
87MP0003693_abnormal_embryo_hatching0.73027317
88MP0001919_abnormal_reproductive_system0.70923424
89MP0005248_abnormal_Harderian_gland0.70755474
90MP0003959_abnormal_lean_body0.69842485
91MP0000230_abnormal_systemic_arterial0.68876431
92MP0009642_abnormal_blood_homeostasis0.66954117
93MP0005164_abnormal_response_to0.66152134
94MP0004084_abnormal_cardiac_muscle0.63799509
95MP0005381_digestive/alimentary_phenotyp0.63756672
96MP0004142_abnormal_muscle_tone0.63362334
97MP0003828_pulmonary_edema0.60865034
98MP0005410_abnormal_fertilization0.60699437
99MP0002160_abnormal_reproductive_system0.58719894
100MP0002693_abnormal_pancreas_physiology0.58231055

Predicted human phenotypes

RankGene SetZ-score
1Agammaglobulinemia (HP:0004432)7.91606215
2Prolonged bleeding time (HP:0003010)5.15732218
3B lymphocytopenia (HP:0010976)4.59210438
4Panhypogammaglobulinemia (HP:0003139)4.54122971
5Abnormality of B cell number (HP:0010975)4.51983103
6Elevated erythrocyte sedimentation rate (HP:0003565)4.40146288
7Cone-rod dystrophy (HP:0000548)3.88979974
8Recurrent corneal erosions (HP:0000495)3.72946772
9Epistaxis (HP:0000421)3.63031707
10Renal cortical cysts (HP:0000803)3.62880930
11Meningitis (HP:0001287)3.61521931
12Recurrent fungal infections (HP:0002841)3.54716580
13Cellulitis (HP:0100658)3.51229005
14Abnormal delayed hypersensitivity skin test (HP:0002963)3.44123558
15Hypomagnesemia (HP:0002917)3.39156094
16Mesangial abnormality (HP:0001966)3.38326802
17Recurrent viral infections (HP:0004429)3.31470150
18Obstructive lung disease (HP:0006536)3.27109281
19Chronic obstructive pulmonary disease (HP:0006510)3.27109281
20Myositis (HP:0100614)3.26968249
21Increased IgE level (HP:0003212)3.26746292
22Recurrent abscess formation (HP:0002722)3.18224993
23Petechiae (HP:0000967)3.15180304
24Chronic otitis media (HP:0000389)3.11571636
25Recurrent skin infections (HP:0001581)3.10162309
26Chronic diarrhea (HP:0002028)3.07328108
27Encephalitis (HP:0002383)3.03545955
28Inflammation of the large intestine (HP:0002037)3.03420798
29Recurrent bacterial skin infections (HP:0005406)2.96158469
30Autoimmune hemolytic anemia (HP:0001890)2.93729520
31Parakeratosis (HP:0001036)2.92118104
32Chronic mucocutaneous candidiasis (HP:0002728)2.88499945
33Recurrent cutaneous fungal infections (HP:0011370)2.88499945
34Menorrhagia (HP:0000132)2.85759152
35Abnormal platelet volume (HP:0011876)2.84785187
36Severe combined immunodeficiency (HP:0004430)2.82369754
37Gastrointestinal inflammation (HP:0004386)2.82199731
38Hypertensive crisis (HP:0100735)2.78834359
39Purpura (HP:0000979)2.78507728
40Autoimmune thrombocytopenia (HP:0001973)2.76524874
41Mediastinal lymphadenopathy (HP:0100721)2.74255851
42Eczematoid dermatitis (HP:0000976)2.74022188
43Orchitis (HP:0100796)2.73674516
44Urticaria (HP:0001025)2.71044104
45Unilateral renal agenesis (HP:0000122)2.70759043
46Sepsis (HP:0100806)2.67968044
47Osteomyelitis (HP:0002754)2.66932676
48Colitis (HP:0002583)2.65554447
49Acute lymphatic leukemia (HP:0006721)2.64985514
50Xerostomia (HP:0000217)2.60112906
51Skin rash (HP:0000988)2.57713733
52Abnormality of lateral ventricle (HP:0030047)2.57218762
53Abnormality of the prostate (HP:0008775)2.56415173
54Chest pain (HP:0100749)2.55485518
55Cerebellar dysplasia (HP:0007033)2.54019192
56Premature loss of primary teeth (HP:0006323)2.53600194
57Increased mean platelet volume (HP:0011877)2.50513193
58Tetany (HP:0001281)2.46100136
59Abnormality of magnesium homeostasis (HP:0004921)2.45858184
60Decreased central vision (HP:0007663)2.44825129
61Seborrheic dermatitis (HP:0001051)2.42083559
62Gingival bleeding (HP:0000225)2.41135106
63Absent rod-and cone-mediated responses on ERG (HP:0007688)2.38374997
64Recurrent pneumonia (HP:0006532)2.38325111
65Vasculitis (HP:0002633)2.34968948
66Cheilitis (HP:0100825)2.32482235
67Recurrent lower respiratory tract infections (HP:0002783)2.28123781
68Combined immunodeficiency (HP:0005387)2.25890062
69Leukocytosis (HP:0001974)2.24477685
70Bell-shaped thorax (HP:0001591)2.24113746
71Abnormality of T cell physiology (HP:0011840)2.22877675
72Papilloma (HP:0012740)2.22595374
73Verrucae (HP:0200043)2.22595374
74Prolonged neonatal jaundice (HP:0006579)2.20599607
75Aplasia/Hypoplasia of the thymus (HP:0010515)2.19855686
76Gastrointestinal stroma tumor (HP:0100723)2.17944050
77Truncus arteriosus (HP:0001660)2.17714659
78Stomatitis (HP:0010280)2.16602602
79Alopecia of scalp (HP:0002293)2.15938286
80Recurrent gram-negative bacterial infections (HP:0005420)2.13988527
81Brushfield spots (HP:0001088)2.08775155
82Keratitis (HP:0000491)2.05526527
83Syringomyelia (HP:0003396)2.03570972
84Spinal cord lesions (HP:0100561)2.03570972
85Gastrointestinal infarctions (HP:0005244)2.01893107
86Pulmonary infiltrates (HP:0002113)2.01545740
87Skin ulcer (HP:0200042)1.98819605
88Thyroiditis (HP:0100646)1.97963302
89Abnormality of T cells (HP:0002843)1.96293406
90Anhidrosis (HP:0000970)1.96011899
91Granulocytopenia (HP:0001913)1.95792409
92Spontaneous hematomas (HP:0007420)1.92935347
93Viral hepatitis (HP:0006562)1.92217656
94Constricted visual fields (HP:0001133)1.91882675
95Abnormality of macrophages (HP:0004311)1.91394885
96Abnormality of dental color (HP:0011073)1.90993180
97Stomach cancer (HP:0012126)1.89737869
98Chronic sinusitis (HP:0011109)1.87757040
99Recurrent bronchitis (HP:0002837)1.86723188
100Retrobulbar optic neuritis (HP:0100654)1.86722085

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K138.36890080
2MAP4K13.78571534
3MAP3K143.70418999
4ERN13.63378714
5TAOK32.93566457
6KIT2.72410760
7MAP3K72.52677337
8RIPK42.45578645
9TESK22.25671628
10BTK2.02677894
11FLT31.98764707
12EIF2AK31.96793612
13SYK1.82854984
14MAP2K31.72480628
15CSF1R1.72165843
16IKBKB1.70184209
17TNK21.65690540
18PASK1.62058966
19CDK191.60573040
20IRAK41.53935028
21TBK11.48979503
22GRK61.44628480
23BLK1.37232971
24TEC1.36632563
25CDK81.33744299
26MAP3K111.29420015
27VRK21.27057597
28ZAK1.20910057
29PRKCQ1.16387045
30TYK21.16186111
31MAPK121.15496982
32MST41.08260798
33PRKD21.03001319
34FES1.01505938
35LYN1.01419572
36MAPK110.96818643
37MATK0.96800887
38SMG10.95729818
39HCK0.90604365
40IKBKE0.88964818
41KDR0.87163340
42BCKDK0.86467914
43ITK0.81894041
44STK240.81278290
45ZAP700.77362104
46JAK30.76070700
47ADRBK20.75708096
48LCK0.75366558
49MET0.73961409
50MAP2K60.72228336
51CHUK0.72225862
52STK30.71618366
53LRRK20.71562553
54MARK20.70600709
55PLK40.70540230
56CAMKK10.69446694
57EEF2K0.65824656
58PIM10.65709067
59SIK20.65575189
60MAPK130.62412483
61NME20.60922974
62TXK0.59421564
63MAP3K10.59146058
64NEK20.58685241
65CLK10.54864178
66CCNB10.51968362
67PDK10.42128463
68RPS6KA40.40682496
69GRK10.37662781
70CSK0.37568553
71RPS6KA60.36088394
72DAPK20.34647325
73PTK2B0.34197991
74RPS6KC10.34047593
75RPS6KL10.34047593
76MAPK70.33409714
77ATR0.32881094
78DYRK1B0.31886498
79PRKAA20.30572561
80PKN10.30516377
81PIK3CG0.29250020
82BMX0.29034005
83MAPKAPK50.28017176
84CAMK10.27815219
85TIE10.27471810
86PRKCZ0.26566804
87FGFR20.26420756
88IGF1R0.26213239
89RPS6KB20.25629980
90PRKCD0.25454601
91JAK20.25029475
92MAPKAPK30.24986887
93TGFBR10.24601328
94CDK40.24585368
95IRAK10.24578453
96BMPR20.21860962
97CHEK20.20736166
98TAF10.20619576
99TRPM70.20149201
100PRKCH0.19442793

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.98820089
2Intestinal immune network for IgA production_Homo sapiens_hsa046723.62555978
3Allograft rejection_Homo sapiens_hsa053303.41901078
4Asthma_Homo sapiens_hsa053103.32834272
5Autoimmune thyroid disease_Homo sapiens_hsa053202.99311419
6Graft-versus-host disease_Homo sapiens_hsa053322.97202405
7B cell receptor signaling pathway_Homo sapiens_hsa046622.60210159
8Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.48018931
9Type I diabetes mellitus_Homo sapiens_hsa049402.35657246
10Leishmaniasis_Homo sapiens_hsa051402.30424681
11Platelet activation_Homo sapiens_hsa046112.11322022
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.97559930
13Hematopoietic cell lineage_Homo sapiens_hsa046401.92062797
14Homologous recombination_Homo sapiens_hsa034401.88723997
15Staphylococcus aureus infection_Homo sapiens_hsa051501.85850986
16RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.73926234
17Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.73388915
18Osteoclast differentiation_Homo sapiens_hsa043801.73347069
19NF-kappa B signaling pathway_Homo sapiens_hsa040641.72620494
20Viral myocarditis_Homo sapiens_hsa054161.69025732
21Toxoplasmosis_Homo sapiens_hsa051451.63351821
22Antigen processing and presentation_Homo sapiens_hsa046121.63051698
23Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.61678494
24Toll-like receptor signaling pathway_Homo sapiens_hsa046201.59752879
25Herpes simplex infection_Homo sapiens_hsa051681.55711279
26Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.47914880
27Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.38593693
28Vitamin digestion and absorption_Homo sapiens_hsa049771.36852857
29Tuberculosis_Homo sapiens_hsa051521.35861804
30Acute myeloid leukemia_Homo sapiens_hsa052211.34807153
31Ribosome_Homo sapiens_hsa030101.33848046
32Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.30875377
33Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.15492946
34Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.11332469
35SNARE interactions in vesicular transport_Homo sapiens_hsa041301.10619377
36Base excision repair_Homo sapiens_hsa034101.09406720
37NOD-like receptor signaling pathway_Homo sapiens_hsa046211.07980832
38Influenza A_Homo sapiens_hsa051641.07525553
39Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.07329947
40Sulfur relay system_Homo sapiens_hsa041221.05680369
41Shigellosis_Homo sapiens_hsa051311.01938364
42T cell receptor signaling pathway_Homo sapiens_hsa046601.01249113
43Chemokine signaling pathway_Homo sapiens_hsa040620.93367124
44Rheumatoid arthritis_Homo sapiens_hsa053230.88130379
45Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.84845817
46TNF signaling pathway_Homo sapiens_hsa046680.84738302
47Non-homologous end-joining_Homo sapiens_hsa034500.82889305
48Chronic myeloid leukemia_Homo sapiens_hsa052200.82505430
49Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.80660161
50Caffeine metabolism_Homo sapiens_hsa002320.73874450
51Epstein-Barr virus infection_Homo sapiens_hsa051690.73330172
52One carbon pool by folate_Homo sapiens_hsa006700.73149162
53Jak-STAT signaling pathway_Homo sapiens_hsa046300.73037326
54Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.69991317
55Peroxisome_Homo sapiens_hsa041460.68786807
56HTLV-I infection_Homo sapiens_hsa051660.68056958
57alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.67351369
58Transcriptional misregulation in cancer_Homo sapiens_hsa052020.66186277
59Type II diabetes mellitus_Homo sapiens_hsa049300.64199558
60Measles_Homo sapiens_hsa051620.62521639
61African trypanosomiasis_Homo sapiens_hsa051430.62517120
62mTOR signaling pathway_Homo sapiens_hsa041500.60829484
63Hepatitis B_Homo sapiens_hsa051610.57270519
64Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.56998144
65Pancreatic cancer_Homo sapiens_hsa052120.56765358
66Neurotrophin signaling pathway_Homo sapiens_hsa047220.55310604
67Apoptosis_Homo sapiens_hsa042100.55028512
68Pertussis_Homo sapiens_hsa051330.54792679
69Small cell lung cancer_Homo sapiens_hsa052220.54055954
70Phagosome_Homo sapiens_hsa041450.53411539
71Arachidonic acid metabolism_Homo sapiens_hsa005900.52108438
72Sphingolipid signaling pathway_Homo sapiens_hsa040710.51599579
73Malaria_Homo sapiens_hsa051440.48727012
74Leukocyte transendothelial migration_Homo sapiens_hsa046700.48420765
75RNA polymerase_Homo sapiens_hsa030200.48124318
76Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.47514067
77Nucleotide excision repair_Homo sapiens_hsa034200.45220924
78Linoleic acid metabolism_Homo sapiens_hsa005910.44998786
79Pyrimidine metabolism_Homo sapiens_hsa002400.44091862
80Collecting duct acid secretion_Homo sapiens_hsa049660.44026033
81Other glycan degradation_Homo sapiens_hsa005110.43632651
82ABC transporters_Homo sapiens_hsa020100.42700953
83Hepatitis C_Homo sapiens_hsa051600.42549634
84Purine metabolism_Homo sapiens_hsa002300.40532167
85Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.38820787
86DNA replication_Homo sapiens_hsa030300.35414469
87Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.35257340
88Inositol phosphate metabolism_Homo sapiens_hsa005620.34377004
89Carbohydrate digestion and absorption_Homo sapiens_hsa049730.33364057
90Non-small cell lung cancer_Homo sapiens_hsa052230.30328736
91Systemic lupus erythematosus_Homo sapiens_hsa053220.29303661
92Insulin resistance_Homo sapiens_hsa049310.28797212
93MAPK signaling pathway_Homo sapiens_hsa040100.27583434
94Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.27576498
95Drug metabolism - other enzymes_Homo sapiens_hsa009830.27566235
96Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.27032568
97Vascular smooth muscle contraction_Homo sapiens_hsa042700.25194930
98Endocytosis_Homo sapiens_hsa041440.24466077
99VEGF signaling pathway_Homo sapiens_hsa043700.23910943
100Adipocytokine signaling pathway_Homo sapiens_hsa049200.21254293

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