ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	negative regulation of sodium ion transport (GO:0010766)	9.64561378
2	negative regulation of potassium ion transmembrane transport (GO:1901380)	8.78675716
3	protein polyglutamylation (GO:0018095)	8.57972896
4	estrogen biosynthetic process (GO:0006703)	8.30755578
5	regulation of tight junction assembly (GO:2000810)	7.64704251
6	toxin transport (GO:1901998)	7.21958454
7	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	7.01620571
8	negative regulation of systemic arterial blood pressure (GO:0003085)	6.84870520
9	pyrimidine nucleotide catabolic process (GO:0006244)	6.55366041
10	definitive hemopoiesis (GO:0060216)	6.28483615
11	oligosaccharide biosynthetic process (GO:0009312)	6.04111382
12	base-excision repair, AP site formation (GO:0006285)	5.92159835
13	axoneme assembly (GO:0035082)	5.77522125
14	androgen biosynthetic process (GO:0006702)	5.67599008
15	positive regulation of B cell differentiation (GO:0045579)	5.58006336
16	epithelial cell differentiation involved in kidney development (GO:0035850)	5.43270726
17	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	5.02831096
18	negative regulation of erythrocyte differentiation (GO:0045647)	4.83220043
19	response to salt stress (GO:0009651)	4.80611027
20	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:004316	4.67528644
21	aggressive behavior (GO:0002118)	4.53738743
22	barbed-end actin filament capping (GO:0051016)	4.44677712
23	negative regulation of potassium ion transport (GO:0043267)	4.41194287
24	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	4.38862647
25	response to oxygen radical (GO:0000305)	4.36714710
26	hemoglobin metabolic process (GO:0020027)	4.32260664
27	ventricular cardiac muscle cell action potential (GO:0086005)	4.25975412
28	drug transport (GO:0015893)	4.23796784
29	negative regulation of fibroblast apoptotic process (GO:2000270)	4.10911920
30	GPI anchor biosynthetic process (GO:0006506)	3.93132189
31	regulation of B cell differentiation (GO:0045577)	3.88105504
32	positive regulation of cation channel activity (GO:2001259)	3.85069008
33	regulation of female receptivity (GO:0045924)	3.83433685
34	regulation of chromatin binding (GO:0035561)	3.82710678
35	spliceosomal tri-snRNP complex assembly (GO:0000244)	3.72598542
36	eye photoreceptor cell differentiation (GO:0001754)	3.69291362
37	photoreceptor cell differentiation (GO:0046530)	3.69291362
38	estrogen metabolic process (GO:0008210)	3.64277485
39	ketone biosynthetic process (GO:0042181)	3.58256374
40	thrombin receptor signaling pathway (GO:0070493)	3.57822151
41	polyamine biosynthetic process (GO:0006596)	3.52426932
42	GPI anchor metabolic process (GO:0006505)	3.46509859
43	regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)	3.40733324
44	cardiolipin metabolic process (GO:0032048)	3.34363843
45	regulation of antigen processing and presentation (GO:0002577)	3.34099015
46	pentose-phosphate shunt (GO:0006098)	3.33876029
47	Arp2/3 complex-mediated actin nucleation (GO:0034314)	3.29149188
48	female mating behavior (GO:0060180)	3.27111829
49	positive thymic T cell selection (GO:0045059)	3.25104645
50	endothelium development (GO:0003158)	3.25064596
51	negative regulation of granulocyte differentiation (GO:0030853)	3.22446415
52	positive regulation of gamma-delta T cell activation (GO:0046645)	3.20799329
53	regulation of B cell receptor signaling pathway (GO:0050855)	3.18997679
54	polyketide metabolic process (GO:0030638)	3.18740311
55	doxorubicin metabolic process (GO:0044598)	3.18740311
56	daunorubicin metabolic process (GO:0044597)	3.18740311
57	B cell receptor signaling pathway (GO:0050853)	3.18232035
58	antigen processing and presentation of endogenous antigen (GO:0019883)	3.17887826
59	zinc ion homeostasis (GO:0055069)	3.17821791
60	deoxyribonucleotide catabolic process (GO:0009264)	3.10845368
61	DNA damage response, detection of DNA damage (GO:0042769)	3.07409125
62	DNA demethylation (GO:0080111)	3.03708168
63	Peyers patch development (GO:0048541)	2.97991101
64	mucosal-associated lymphoid tissue development (GO:0048537)	2.97991101
65	tyrosine phosphorylation of STAT protein (GO:0007260)	2.94983870
66	cell volume homeostasis (GO:0006884)	2.92165143
67	positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)	2.91450320
68	positive regulation of antigen processing and presentation (GO:0002579)	2.91110863
69	valine metabolic process (GO:0006573)	2.91048397
70	ribosomal small subunit assembly (GO:0000028)	2.89619886
71	branched-chain amino acid metabolic process (GO:0009081)	2.88988778
72	ribonucleoprotein complex disassembly (GO:0032988)	2.87690963
73	aminoglycoside antibiotic metabolic process (GO:0030647)	2.84288217
74	NADPH regeneration (GO:0006740)	2.82972851
75	angiogenesis involved in wound healing (GO:0060055)	2.81926978
76	megakaryocyte development (GO:0035855)	2.80064557
77	deoxyribose phosphate catabolic process (GO:0046386)	2.80042702
78	positive regulation of activated T cell proliferation (GO:0042104)	2.79302712
79	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.78861176
80	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.78861176
81	negative thymic T cell selection (GO:0045060)	2.77533070
82	positive regulation of histone deacetylation (GO:0031065)	2.77326458
83	GTP biosynthetic process (GO:0006183)	2.76771440
84	regulation of potassium ion transmembrane transporter activity (GO:1901016)	2.75151441
85	regulation of dendritic cell antigen processing and presentation (GO:0002604)	2.74273334
86	negative regulation of ion transmembrane transporter activity (GO:0032413)	2.73342893
87	peptidyl-histidine modification (GO:0018202)	2.72247412
88	androgen metabolic process (GO:0008209)	2.71404241
89	regulation of gamma-delta T cell differentiation (GO:0045586)	2.71152436
90	protein localization to cell surface (GO:0034394)	2.68578362
91	DNA dealkylation (GO:0035510)	2.68310139
92	negative T cell selection (GO:0043383)	2.66732277
93	positive regulation of interleukin-2 biosynthetic process (GO:0045086)	2.62644301
94	actin nucleation (GO:0045010)	2.62052441
95	positive regulation of natural killer cell differentiation (GO:0032825)	2.60039411
96	negative regulation of nitric oxide biosynthetic process (GO:0045019)	2.57224578
97	peptidyl-glutamic acid modification (GO:0018200)	2.56955681
98	response to peptidoglycan (GO:0032494)	2.55904009
99	glucose catabolic process (GO:0006007)	2.55515784
100	negative regulation of potassium ion transmembrane transporter activity (GO:1901017)	10.0284622

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	8.54085877
2	GATA1_22025678_ChIP-Seq_K562_Human	5.66180753
3	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	4.74826343
4	SCL_19346495_ChIP-Seq_HPC-7_Human	4.18897639
5	BP1_19119308_ChIP-ChIP_Hs578T_Human	3.87857453
6	IRF8_22096565_ChIP-ChIP_GC-B_Human	3.79332151
7	EGR1_19374776_ChIP-ChIP_THP-1_Human	3.20281774
8	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	2.92144256
9	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.39262289
10	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	2.34332924
11	RUNX_20019798_ChIP-Seq_JUKART_Human	2.23277486
12	MECOM_23826213_ChIP-Seq_KASUMI_Mouse	2.08014463
13	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	11.0338889
14	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.98836146
15	MYC_22102868_ChIP-Seq_BL_Human	1.91552941
16	MYB_26560356_Chip-Seq_TH2_Human	1.86752496
17	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.84239358
18	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.80804013
19	VDR_21846776_ChIP-Seq_THP-1_Human	1.78488117
20	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.74313106
21	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.72106492
22	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.70531441
23	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.60127883
24	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.58553361
25	LMO2_20887958_ChIP-Seq_HPC-7_Mouse	1.57279149
26	E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human	1.55979229
27	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.52518346
28	CIITA_25753668_ChIP-Seq_RAJI_Human	1.50162553
29	GATA2_20887958_ChIP-Seq_HPC-7_Mouse	1.47372756
30	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.44286204
31	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.44187610
32	GATA1_19941826_ChIP-Seq_K562_Human	1.43799189
33	VDR_24763502_ChIP-Seq_THP-1_Human	1.42064118
34	BCL6_27268052_Chip-Seq_Bcells_Human	1.40116542
35	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.34057588
36	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.34015342
37	UTX_26944678_Chip-Seq_JUKART_Human	1.33364648
38	MAF_26560356_Chip-Seq_TH1_Human	1.30319396
39	FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse	1.28963274
40	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.24600901
41	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.24346561
42	SPI1_23547873_ChIP-Seq_NB4_Human	1.23479048
43	RUNX1_17652178_ChIP-ChIP_JURKAT_Human	1.23109760
44	MYB_26560356_Chip-Seq_TH1_Human	1.18571987
45	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.17537688
46	GATA2_22383799_ChIP-Seq_G1ME_Mouse	1.16931141
47	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.15127430
48	KDM2B_26808549_Chip-Seq_SIL-ALL_Human	1.13504128
49	SPI1_23127762_ChIP-Seq_K562_Human	1.13018344
50	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.08440261
51	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.07443425
52	BCOR_27268052_Chip-Seq_Bcells_Human	1.06242133
53	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.03767540
54	MYB_21317192_ChIP-Seq_ERMYB_Mouse	0.99416596
55	NANOG_20526341_ChIP-Seq_ESCs_Human	0.99171218
56	GATA2_19941826_ChIP-Seq_K562_Human	0.98696052
57	VDR_23849224_ChIP-Seq_CD4+_Human	0.98523334
58	RUNX1_22412390_ChIP-Seq_EML_Mouse	0.98140305
59	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	0.96807573
60	STAT4_19710469_ChIP-ChIP_TH1__Mouse	0.96554850
61	MAF_26560356_Chip-Seq_TH2_Human	0.94800923
62	TAF15_26573619_Chip-Seq_HEK293_Human	0.93705320
63	E2F1_20622854_ChIP-Seq_HELA_Human	0.92791380
64	GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.92494455
65	HOXB4_20404135_ChIP-ChIP_EML_Mouse	0.90297223
66	GATA1_19941827_ChIP-Seq_MEL_Mouse	0.89797745
67	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	0.88447143
68	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	0.87915274
69	ELF1_20517297_ChIP-Seq_JURKAT_Human	0.87237595
70	CTCF_20526341_ChIP-Seq_ESCs_Human	0.86511808
71	P300_27268052_Chip-Seq_Bcells_Human	0.86351846
72	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	0.83930583
73	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.81795251
74	GATA2_21666600_ChIP-Seq_HMVEC_Human	0.81424154
75	ELK3_25401928_ChIP-Seq_HUVEC_Human	0.79524996
76	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.78909239
77	LXR_22292898_ChIP-Seq_THP-1_Human	0.77381545
78	VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human	0.77259869
79	CTCF_21964334_ChIP-Seq_BJAB-B_Human	0.77046713
80	GATA3_27048872_Chip-Seq_THYMUS_Human	0.76597840
81	NCOR1_26117541_ChIP-Seq_K562_Human	0.75884234
82	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.75849044
83	RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.73847270
84	CTCF_21964334_Chip-Seq_Bcells_Human	0.73080091
85	P68_20966046_ChIP-Seq_HELA_Human	0.71607336
86	NOTCH1_21737748_ChIP-Seq_TLL_Human	0.71242005
87	KDM2B_26808549_Chip-Seq_SUP-B15_Human	0.71219071
88	GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.69918479
89	NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse	0.69228126
90	CTCF_26484167_Chip-Seq_Bcells_Mouse	0.68939818
91	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.68542221
92	ESET_19884257_ChIP-Seq_ESCs_Mouse	0.67626481
93	SPI1_20517297_ChIP-Seq_HL60_Human	0.67217629
94	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.67133780
95	DNAJC2_21179169_ChIP-ChIP_NT2_Human	0.65424535
96	CTCF_27219007_Chip-Seq_ERYTHROID_Human	0.65360544
97	KDM2B_26808549_Chip-Seq_DND41_Human	0.64456417
98	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.64126033
99	PHF8_20622854_ChIP-Seq_HELA_Human	0.63241954
100	ERG_20517297_ChIP-Seq_VCAP_Human	0.63052701

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000465_gastrointestinal_hemorrhage	6.49543734
2	MP0003567_abnormal_fetal_cardiomyocyte	3.15296041
3	MP0005645_abnormal_hypothalamus_physiol	2.88991432
4	MP0005646_abnormal_pituitary_gland	2.80941188
5	MP0001545_abnormal_hematopoietic_system	2.73917373
6	MP0005397_hematopoietic_system_phenotyp	2.73917373
7	MP0003075_altered_response_to	2.56320676
8	MP0002837_dystrophic_cardiac_calcinosis	2.56244527
9	MP0003787_abnormal_imprinting	2.53083303
10	MP0005451_abnormal_body_composition	2.51321675
11	MP0002009_preneoplasia	2.44619587
12	MP0002653_abnormal_ependyma_morphology	2.42695611
13	MP0003436_decreased_susceptibility_to	2.37857182
14	MP0001835_abnormal_antigen_presentation	2.31416876
15	MP0001664_abnormal_digestion	2.23429220
16	MP0001800_abnormal_humoral_immune	2.20464996
17	MP0003172_abnormal_lysosome_physiology	2.18619199
18	MP0009278_abnormal_bone_marrow	2.12116364
19	MP0002876_abnormal_thyroid_physiology	2.11652660
20	MP0003763_abnormal_thymus_physiology	1.98804879
21	MP0002139_abnormal_hepatobiliary_system	1.97227926
22	MP0000681_abnormal_thyroid_gland	1.92954480
23	MP0005464_abnormal_platelet_physiology	1.89399387
24	MP0008875_abnormal_xenobiotic_pharmacok	1.87392894
25	MP0002138_abnormal_hepatobiliary_system	1.87205086
26	MP0002398_abnormal_bone_marrow	1.87031887
27	MP0002452_abnormal_antigen_presenting	1.76076340
28	MP0002723_abnormal_immune_serum	1.70756640
29	MP0001790_abnormal_immune_system	1.69649256
30	MP0005387_immune_system_phenotype	1.69649256
31	MP0000689_abnormal_spleen_morphology	1.66476124
32	MP0002148_abnormal_hypersensitivity_rea	1.66358319
33	MP0005000_abnormal_immune_tolerance	1.66357226
34	MP0002420_abnormal_adaptive_immunity	1.64815790
35	MP0001819_abnormal_immune_cell	1.62356755
36	MP0004233_abnormal_muscle_weight	1.56736656
37	MP0001968_abnormal_touch/_nociception	1.56640140
38	MP0002166_altered_tumor_susceptibility	1.56441972
39	MP0000716_abnormal_immune_system	1.53873943
40	MP0003718_maternal_effect	1.52920435
41	MP0001905_abnormal_dopamine_level	1.48290008
42	MP0003724_increased_susceptibility_to	1.46764352
43	MP0005166_decreased_susceptibility_to	1.44315398
44	MP0000428_abnormal_craniofacial_morphol	1.40562012
45	MP0000733_abnormal_muscle_development	1.40115965
46	MP0005025_abnormal_response_to	1.38538429
47	MP0003315_abnormal_perineum_morphology	1.33859246
48	MP0008469_abnormal_protein_level	1.33682024
49	MP0005075_abnormal_melanosome_morpholog	1.33570226
50	MP0002429_abnormal_blood_cell	1.31329657
51	MP0002396_abnormal_hematopoietic_system	1.30146626
52	MP0002419_abnormal_innate_immunity	1.26374518
53	MP0002006_tumorigenesis	1.25159639
54	MP0006292_abnormal_olfactory_placode	1.22790687
55	MP0004808_abnormal_hematopoietic_stem	1.22514441
56	MP0002722_abnormal_immune_system	1.20652009
57	MP0009785_altered_susceptibility_to	1.16996336
58	MP0003959_abnormal_lean_body	1.12739151
59	MP0003183_abnormal_peptide_metabolism	1.10633451
60	MP0001881_abnormal_mammary_gland	1.08850706
61	MP0000678_abnormal_parathyroid_gland	1.08324261
62	MP0009643_abnormal_urine_homeostasis	1.05906699
63	MP0003186_abnormal_redox_activity	1.03439734
64	MP0005551_abnormal_eye_electrophysiolog	1.02258420
65	MP0002160_abnormal_reproductive_system	0.98687568
66	MP0002638_abnormal_pupillary_reflex	0.98183167
67	MP0000516_abnormal_urinary_system	0.97386584
68	MP0005367_renal/urinary_system_phenotyp	0.97386584
69	MP0003690_abnormal_glial_cell	0.95011321
70	MP0004147_increased_porphyrin_level	0.94763912
71	MP0005584_abnormal_enzyme/coenzyme_acti	0.93636656
72	MP0009384_cardiac_valve_regurgitation	0.91928575
73	MP0005671_abnormal_response_to	0.91515551
74	MP0001533_abnormal_skeleton_physiology	0.91459816
75	MP0002234_abnormal_pharynx_morphology	0.90003386
76	MP0001764_abnormal_homeostasis	0.89678738
77	MP0005636_abnormal_mineral_homeostasis	0.89233600
78	MP0003638_abnormal_response/metabolism_	0.85622820
79	MP0001324_abnormal_eye_pigmentation	0.83981887
80	MP0001845_abnormal_inflammatory_respons	0.82516338
81	MP0002733_abnormal_thermal_nociception	0.82296477
82	MP0001765_abnormal_ion_homeostasis	0.79333777
83	MP0002019_abnormal_tumor_incidence	0.79153861
84	MP0003303_peritoneal_inflammation	0.77060608
85	MP0008877_abnormal_DNA_methylation	0.76974819
86	MP0005390_skeleton_phenotype	0.74356156
87	MP0009764_decreased_sensitivity_to	0.74303858
88	MP0003122_maternal_imprinting	0.71663825
89	MP0000685_abnormal_immune_system	0.70701160
90	MP0005385_cardiovascular_system_phenoty	0.68720707
91	MP0001544_abnormal_cardiovascular_syste	0.68720707
92	MP0001851_eye_inflammation	0.65622820
93	MP0009333_abnormal_splenocyte_physiolog	0.65171269
94	MP0003795_abnormal_bone_structure	0.65037439
95	MP0008872_abnormal_physiological_respon	0.64751952
96	MP0005319_abnormal_enzyme/_coenzyme	0.64403580
97	MP0005535_abnormal_body_temperature	0.64035136
98	MP0005165_increased_susceptibility_to	0.63412336
99	MP0010155_abnormal_intestine_physiology	0.62799583
100	MP0001963_abnormal_hearing_physiology	0.62697162

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Reduced antithrombin III activity (HP:0001976)	8.63040097
2	Facial hemangioma (HP:0000329)	7.18079819
3	Abnormality of macular pigmentation (HP:0008002)	6.79528966
4	Abnormality of the lumbar spine (HP:0100712)	6.57700232
5	Thoracolumbar scoliosis (HP:0002944)	6.46450033
6	Thoracic kyphosis (HP:0002942)	6.12791835
7	Abnormality of the columella (HP:0009929)	4.99968688
8	Self-mutilation (HP:0000742)	4.90818103
9	Abnormality of the intrinsic pathway (HP:0010989)	4.78177675
10	Dyschromatopsia (HP:0007641)	4.78144907
11	Capillary hemangiomas (HP:0005306)	4.73943105
12	Agammaglobulinemia (HP:0004432)	4.50694803
13	Protruding tongue (HP:0010808)	4.21913409
14	Central scotoma (HP:0000603)	4.16340002
15	Abnormality of the thoracic spine (HP:0100711)	4.05082282
16	Decreased central vision (HP:0007663)	3.99580900
17	Cellulitis (HP:0100658)	3.92838863
18	Generalized hypotonia (HP:0001290)	3.77702761
19	Abnormal protein glycosylation (HP:0012346)	3.72518829
20	Abnormal glycosylation (HP:0012345)	3.72518829
21	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	3.72518829
22	Abnormal protein N-linked glycosylation (HP:0012347)	3.72518829
23	Alopecia of scalp (HP:0002293)	3.61692868
24	Syringomyelia (HP:0003396)	3.46871343
25	Spinal cord lesions (HP:0100561)	3.46871343
26	Coxa valga (HP:0002673)	3.43389251
27	Macular degeneration (HP:0000608)	3.37300543
28	Cone-rod dystrophy (HP:0000548)	3.30438828
29	Mediastinal lymphadenopathy (HP:0100721)	3.29762600
30	Obstructive lung disease (HP:0006536)	3.21590341
31	Chronic obstructive pulmonary disease (HP:0006510)	3.21590341
32	Hyperthyroidism (HP:0000836)	3.17701716
33	Long eyelashes (HP:0000527)	3.08758883
34	Pustule (HP:0200039)	3.07762125
35	Recurrent fungal infections (HP:0002841)	2.98936786
36	Unsteady gait (HP:0002317)	2.95087511
37	Peritonitis (HP:0002586)	2.88253669
38	Gastrointestinal infarctions (HP:0005244)	2.80899807
39	Abnormal rod and cone electroretinograms (HP:0008323)	2.79069325
40	Eczematoid dermatitis (HP:0000976)	2.71829865
41	Microretrognathia (HP:0000308)	2.65098544
42	Abnormality of the peritoneum (HP:0002585)	2.52554789
43	Seborrheic dermatitis (HP:0001051)	2.41440360
44	Slender long bone (HP:0003100)	2.39418185
45	Recurrent bronchitis (HP:0002837)	2.39274541
46	Thrombocytosis (HP:0001894)	2.39100086
47	Hypertensive crisis (HP:0100735)	2.39089711
48	Abolished electroretinogram (ERG) (HP:0000550)	2.37755604
49	Severe visual impairment (HP:0001141)	2.36243365
50	Chest pain (HP:0100749)	2.35616291
51	Meningitis (HP:0001287)	2.30694576
52	Elevated erythrocyte sedimentation rate (HP:0003565)	2.30478151
53	Proximal placement of thumb (HP:0009623)	2.28580735
54	3-Methylglutaconic aciduria (HP:0003535)	2.25655305
55	Abnormality of T cell physiology (HP:0011840)	2.25585603
56	Spontaneous abortion (HP:0005268)	2.23507233
57	Recurrent pneumonia (HP:0006532)	2.22749371
58	Chronic sinusitis (HP:0011109)	2.19064346
59	Scotoma (HP:0000575)	2.18198190
60	Rib fusion (HP:0000902)	2.15896988
61	Prolonged bleeding time (HP:0003010)	2.14389312
62	J-shaped sella turcica (HP:0002680)	2.12364056
63	Aplastic anemia (HP:0001915)	2.12250194
64	Congenital stationary night blindness (HP:0007642)	2.09886834
65	Abnormality of the prostate (HP:0008775)	2.08427414
66	Metaphyseal dysplasia (HP:0100255)	2.06862243
67	Recurrent sinusitis (HP:0011108)	2.02620312
68	Cheilitis (HP:0100825)	2.01349177
69	Short middle phalanx of the 5th finger (HP:0004220)	1.99540358
70	Epistaxis (HP:0000421)	1.96402552
71	Gingival bleeding (HP:0000225)	1.94818952
72	Amaurosis fugax (HP:0100576)	1.92646902
73	Deviation of the thumb (HP:0009603)	1.92435740
74	Verrucae (HP:0200043)	1.89663161
75	Papilloma (HP:0012740)	1.89663161
76	Ulnar claw (HP:0001178)	1.89588694
77	Congenital primary aphakia (HP:0007707)	1.87211295
78	Recurrent gram-negative bacterial infections (HP:0005420)	1.86676644
79	Supernumerary bones of the axial skeleton (HP:0009144)	1.85221233
80	Beaking of vertebral bodies (HP:0004568)	1.84839815
81	Gait imbalance (HP:0002141)	1.81298876
82	Recurrent lower respiratory tract infections (HP:0002783)	1.81082239
83	Abnormality of macrophages (HP:0004311)	1.80485985
84	Osteomyelitis (HP:0002754)	1.78688287
85	Truncus arteriosus (HP:0001660)	1.75480157
86	Recurrent viral infections (HP:0004429)	1.74648662
87	Neonatal respiratory distress (HP:0002643)	1.74023030
88	Increased IgM level (HP:0003496)	1.73281012
89	Inflammation of the large intestine (HP:0002037)	1.73259336
90	Abnormal delayed hypersensitivity skin test (HP:0002963)	1.71876961
91	Nephrogenic diabetes insipidus (HP:0009806)	1.71120530
92	Panhypogammaglobulinemia (HP:0003139)	1.70600887
93	Supernumerary ribs (HP:0005815)	1.68186411
94	Short clavicles (HP:0000894)	1.67209818
95	Overlapping toe (HP:0001845)	1.66512228
96	Abnormality of the phalanges of the 2nd finger (HP:0009541)	1.65291140
97	Abnormality of T cells (HP:0002843)	1.64573007
98	Alveolar cell carcinoma (HP:0006519)	1.63419703
99	Microvesicular hepatic steatosis (HP:0001414)	1.63026514
100	Vasculitis (HP:0002633)	1.62327859

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	DAPK2	5.70235123
2	DAPK1	3.55595396
3	MAP4K1	3.19828251
4	ERN1	2.97511783
5	TXK	2.95404329
6	TAF1	2.91579162
7	IRAK4	2.82285095
8	VRK2	2.70347566
9	DAPK3	2.57597717
10	TAOK3	2.36167492
11	TNIK	2.26764317
12	GRK6	2.26281612
13	SMG1	2.19697073
14	NUAK1	2.16127116
15	BCKDK	2.09484180
16	TIE1	1.92685800
17	TBK1	1.80220731
18	JAK3	1.75498725
19	TESK2	1.64502590
20	RPS6KC1	1.63113285
21	RPS6KL1	1.63113285
22	KIT	1.61701793
23	RPS6KA6	1.51783742
24	PRKG2	1.51644309
25	KDR	1.49419943
26	HIPK2	1.44335082
27	TYK2	1.39750032
28	MAPKAPK5	1.39393775
29	SYK	1.28576927
30	ZAP70	1.25151948
31	RPS6KA2	1.17810422
32	MAP3K4	1.08732236
33	CDK6	1.03831654
34	ROCK2	0.99301678
35	CDK19	0.96769693
36	BMPR2	0.95967577
37	NEK2	0.90500176
38	VRK1	0.90393011
39	ILK	0.89729701
40	MAPK10	0.89280335
41	PINK1	0.88547312
42	TNK2	0.88510132
43	IKBKB	0.85575085
44	STK4	0.85330864
45	BTK	0.84815217
46	NME2	0.84535431
47	BRAF	0.84046186
48	LYN	0.81795804
49	FLT3	0.81185689
50	TEC	0.80759200
51	PRPF4B	0.80281583
52	HCK	0.79740637
53	JAK2	0.79055473
54	IKBKE	0.77293768
55	MARK3	0.75778660
56	MATK	0.73472596
57	PIM2	0.73333507
58	PRKCD	0.73006638
59	MAPK13	0.70977636
60	PIM1	0.69192272
61	FES	0.68174606
62	RPS6KA4	0.67106189
63	PKN1	0.65778750
64	LCK	0.64227238
65	MKNK1	0.64071320
66	BLK	0.63356996
67	MAPK15	0.63143818
68	NLK	0.62987871
69	ITK	0.62505201
70	LATS1	0.62281729
71	GRK5	0.59786205
72	MAPK11	0.58471160
73	CSF1R	0.56435468
74	MAP3K14	0.55949107
75	PLK4	0.55247638
76	CDC7	0.53425284
77	FYN	0.53006071
78	PRKCQ	0.52452065
79	PBK	0.49314285
80	MAP2K2	0.46523785
81	MAPK3	0.46406138
82	CAMKK1	0.46191727
83	UHMK1	0.44627061
84	RPS6KA1	0.44362233
85	CDK9	0.44356726
86	ABL2	0.44330608
87	CSNK1G3	0.40029739
88	MAPKAPK2	0.39702882
89	RIPK4	0.37336360
90	RPS6KA5	0.36990933
91	PRKD2	0.35024301
92	SIK2	0.34500359
93	CDK7	0.33897103
94	CCNB1	0.32762729
95	MAP2K7	0.32344153
96	MAP3K5	0.31039183
97	IGF1R	0.29072086
98	IRAK2	0.28976383
99	CDK14	0.28420706
100	ATR	0.28404587

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Allograft rejection_Homo sapiens_hsa05330	3.70044322
2	Graft-versus-host disease_Homo sapiens_hsa05332	3.66226851
3	Intestinal immune network for IgA production_Homo sapiens_hsa04672	3.50097122
4	Autoimmune thyroid disease_Homo sapiens_hsa05320	3.49841834
5	Asthma_Homo sapiens_hsa05310	3.48327529
6	Selenocompound metabolism_Homo sapiens_hsa00450	3.16278372
7	Type I diabetes mellitus_Homo sapiens_hsa04940	3.10156941
8	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	2.69504915
9	Primary immunodeficiency_Homo sapiens_hsa05340	2.58384792
10	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.49964990
11	Fatty acid elongation_Homo sapiens_hsa00062	2.45635811
12	Antigen processing and presentation_Homo sapiens_hsa04612	2.35786641
13	Base excision repair_Homo sapiens_hsa03410	2.28919840
14	Leishmaniasis_Homo sapiens_hsa05140	2.26716356
15	Glycerophospholipid metabolism_Homo sapiens_hsa00564	2.06271595
16	Ovarian steroidogenesis_Homo sapiens_hsa04913	2.04942668
17	B cell receptor signaling pathway_Homo sapiens_hsa04662	1.94604431
18	Pentose phosphate pathway_Homo sapiens_hsa00030	1.91543682
19	Viral myocarditis_Homo sapiens_hsa05416	1.88883613
20	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.87329238
21	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.69744278
22	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.69084679
23	Ribosome_Homo sapiens_hsa03010	1.68529995
24	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.59595426
25	Rheumatoid arthritis_Homo sapiens_hsa05323	1.58941162
26	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.56929202
27	Herpes simplex infection_Homo sapiens_hsa05168	1.51057291
28	Ether lipid metabolism_Homo sapiens_hsa00565	1.38932002
29	Acute myeloid leukemia_Homo sapiens_hsa05221	1.36167467
30	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	1.31633986
31	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.15456580
32	Tuberculosis_Homo sapiens_hsa05152	1.11406248
33	Toxoplasmosis_Homo sapiens_hsa05145	1.08281299
34	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	1.07113934
35	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.05315718
36	NF-kappa B signaling pathway_Homo sapiens_hsa04064	1.04289619
37	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	1.00392832
38	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.99418927
39	Measles_Homo sapiens_hsa05162	0.98775001
40	Tyrosine metabolism_Homo sapiens_hsa00350	0.95251676
41	Platelet activation_Homo sapiens_hsa04611	0.92658120
42	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.86173269
43	Pyrimidine metabolism_Homo sapiens_hsa00240	0.84906163
44	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.83866859
45	Osteoclast differentiation_Homo sapiens_hsa04380	0.83454378
46	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.82462889
47	Salivary secretion_Homo sapiens_hsa04970	0.82064412
48	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.81281920
49	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.80184143
50	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.79284211
51	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.70225914
52	Shigellosis_Homo sapiens_hsa05131	0.66866412
53	Butanoate metabolism_Homo sapiens_hsa00650	0.66353738
54	Influenza A_Homo sapiens_hsa05164	0.65330546
55	Arginine and proline metabolism_Homo sapiens_hsa00330	0.64321873
56	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.64250144
57	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.60874152
58	Phototransduction_Homo sapiens_hsa04744	0.56486658
59	Linoleic acid metabolism_Homo sapiens_hsa00591	0.56167617
60	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.54886413
61	Carbon metabolism_Homo sapiens_hsa01200	0.53853070
62	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.51743186
63	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.51566489
64	Olfactory transduction_Homo sapiens_hsa04740	0.50482178
65	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.48656247
66	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.48243109
67	Long-term depression_Homo sapiens_hsa04730	0.47026157
68	Malaria_Homo sapiens_hsa05144	0.45474099
69	Non-homologous end-joining_Homo sapiens_hsa03450	0.45071126
70	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.44785249
71	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.44382093
72	African trypanosomiasis_Homo sapiens_hsa05143	0.41177851
73	Bladder cancer_Homo sapiens_hsa05219	0.39737616
74	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.39512747
75	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.39150084
76	Melanoma_Homo sapiens_hsa05218	0.37890792
77	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.37140156
78	HTLV-I infection_Homo sapiens_hsa05166	0.34772539
79	Pertussis_Homo sapiens_hsa05133	0.34564780
80	Propanoate metabolism_Homo sapiens_hsa00640	0.32814456
81	Thyroid cancer_Homo sapiens_hsa05216	0.32051359
82	Basal transcription factors_Homo sapiens_hsa03022	0.28068278
83	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.28020391
84	Prolactin signaling pathway_Homo sapiens_hsa04917	0.27800915
85	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.27046801
86	Renin secretion_Homo sapiens_hsa04924	0.25224256
87	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.24360220
88	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.23740468
89	Phagosome_Homo sapiens_hsa04145	0.22434847
90	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.21639298
91	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.21494066
92	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.21348309
93	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.21267032
94	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.20676781
95	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.20429029
96	TNF signaling pathway_Homo sapiens_hsa04668	0.20375365
97	Lysosome_Homo sapiens_hsa04142	0.19648870
98	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.18718420
99	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.18463075
100	Homologous recombination_Homo sapiens_hsa03440	0.17689381

ABHD17AP6

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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