ABHD3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein containing an alpha/beta hydrolase fold, which is a catalytic domain found in a very wide range of enzymes. The function of this protein has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.53531232
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.40303529
3positive regulation of gamma-delta T cell activation (GO:0046645)5.32476801
4negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.31575412
5negative regulation of cell killing (GO:0031342)5.31575412
6antigen processing and presentation of endogenous antigen (GO:0019883)5.23594722
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.22260808
8L-phenylalanine catabolic process (GO:0006559)5.22260808
9antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.06974554
10erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.75251782
11L-phenylalanine metabolic process (GO:0006558)4.75251782
12triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.60994149
13regulation of B cell receptor signaling pathway (GO:0050855)4.52358112
14alpha-linolenic acid metabolic process (GO:0036109)4.42166207
15fatty acid elongation (GO:0030497)4.38698281
16central nervous system myelination (GO:0022010)4.38588574
17axon ensheathment in central nervous system (GO:0032291)4.38588574
18aromatic amino acid family catabolic process (GO:0009074)4.34934875
19neutrophil activation involved in immune response (GO:0002283)4.24570008
20positive regulation by symbiont of host defense response (GO:0052509)4.20839806
21modulation by symbiont of host defense response (GO:0052031)4.20839806
22modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.20839806
23modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.20839806
24positive regulation by organism of defense response of other organism involved in symbiotic interact4.20839806
25modulation by symbiont of host immune response (GO:0052553)4.20839806
26low-density lipoprotein particle remodeling (GO:0034374)4.16055732
27bile acid biosynthetic process (GO:0006699)4.02088157
28regulation of interferon-beta biosynthetic process (GO:0045357)4.01773924
29cysteine metabolic process (GO:0006534)3.94853057
30regulation of gamma-delta T cell activation (GO:0046643)3.93409953
31positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.90810886
32reverse cholesterol transport (GO:0043691)3.89452070
33very long-chain fatty acid metabolic process (GO:0000038)3.88233563
34response to interleukin-15 (GO:0070672)3.86609849
35regulation of gamma-delta T cell differentiation (GO:0045586)3.84123480
36regulation of cholesterol esterification (GO:0010872)3.81174622
37detection of other organism (GO:0098543)3.79001397
38sulfur amino acid catabolic process (GO:0000098)3.77274437
39high-density lipoprotein particle remodeling (GO:0034375)3.76703465
40glyoxylate metabolic process (GO:0046487)3.75671861
41cellular response to interleukin-15 (GO:0071350)3.75600482
42immunoglobulin mediated immune response (GO:0016064)3.74035401
43L-amino acid import (GO:0043092)3.71699161
44macrophage activation involved in immune response (GO:0002281)3.67933950
45glutamate metabolic process (GO:0006536)3.66665983
46negative thymic T cell selection (GO:0045060)3.65089057
47protein-lipid complex remodeling (GO:0034368)3.64593019
48macromolecular complex remodeling (GO:0034367)3.64593019
49plasma lipoprotein particle remodeling (GO:0034369)3.64593019
50negative T cell selection (GO:0043383)3.63543046
51tryptophan catabolic process (GO:0006569)3.63469231
52indole-containing compound catabolic process (GO:0042436)3.63469231
53indolalkylamine catabolic process (GO:0046218)3.63469231
54detection of bacterium (GO:0016045)3.59667587
55C4-dicarboxylate transport (GO:0015740)3.57323634
56neutrophil activation (GO:0042119)3.56728761
57cellular modified amino acid catabolic process (GO:0042219)3.52096914
58negative regulation of lymphocyte mediated immunity (GO:0002707)3.50082935
59respiratory burst (GO:0045730)3.49743869
60cellular ketone body metabolic process (GO:0046950)3.47473059
61dicarboxylic acid biosynthetic process (GO:0043650)3.43371160
62short-chain fatty acid metabolic process (GO:0046459)3.41162260
63kynurenine metabolic process (GO:0070189)3.39852502
64tryptophan metabolic process (GO:0006568)3.39283633
65detection of external biotic stimulus (GO:0098581)3.37087571
66detection of molecule of bacterial origin (GO:0032490)3.33860017
67bile acid metabolic process (GO:0008206)3.31991117
68granulocyte activation (GO:0036230)3.29358560
69B cell receptor signaling pathway (GO:0050853)3.27146588
70dendritic cell chemotaxis (GO:0002407)3.26589470
71alanine transport (GO:0032328)3.26494546
72cellular response to type I interferon (GO:0071357)3.25288205
73type I interferon signaling pathway (GO:0060337)3.25288205
74alpha-amino acid catabolic process (GO:1901606)3.24540446
75long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.24011511
76homocysteine metabolic process (GO:0050667)3.23854053
77antigen processing and presentation via MHC class Ib (GO:0002475)3.23597117
78fatty-acyl-CoA biosynthetic process (GO:0046949)3.22487056
79coenzyme catabolic process (GO:0009109)3.22076922
80gamma-aminobutyric acid transport (GO:0015812)3.21810891
81response to type I interferon (GO:0034340)3.21588236
82regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.19179934
83response to peptidoglycan (GO:0032494)3.18321689
84fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.17870912
85cellular extravasation (GO:0045123)3.16754128
86T cell migration (GO:0072678)3.15340745
87cellular amino acid catabolic process (GO:0009063)3.14339155
88regulation of cholesterol biosynthetic process (GO:0045540)3.14152781
89serine family amino acid catabolic process (GO:0009071)3.13834442
90amino acid import (GO:0043090)3.13716515
91negative regulation of interleukin-12 production (GO:0032695)3.13051107
92negative regulation of T cell mediated immunity (GO:0002710)3.11133959
93germinal center formation (GO:0002467)3.09926854
94production of molecular mediator involved in inflammatory response (GO:0002532)3.09593387
95B cell mediated immunity (GO:0019724)3.08844242
96negative regulation of leukocyte mediated immunity (GO:0002704)3.08401516
97leukocyte aggregation (GO:0070486)3.07931297
98positive regulation of interferon-alpha production (GO:0032727)3.07602120
99very-low-density lipoprotein particle assembly (GO:0034379)3.07389858
100amino-acid betaine metabolic process (GO:0006577)3.06660583
101cholesterol biosynthetic process (GO:0006695)3.05645541
102aromatic amino acid family metabolic process (GO:0009072)3.05414218
103regulation of T cell mediated cytotoxicity (GO:0001914)3.05376738
104positive thymic T cell selection (GO:0045059)3.04999588
105Arp2/3 complex-mediated actin nucleation (GO:0034314)3.04315255
106regulation of triglyceride catabolic process (GO:0010896)3.04070831
107ketone body metabolic process (GO:1902224)3.02477835
108interferon-gamma secretion (GO:0072643)3.00436708
109aspartate family amino acid catabolic process (GO:0009068)2.99903591
110lysine catabolic process (GO:0006554)2.99734043
111lysine metabolic process (GO:0006553)2.99734043
112dendritic cell migration (GO:0036336)2.99581706
113cellular biogenic amine catabolic process (GO:0042402)2.99244937
114amine catabolic process (GO:0009310)2.99244937
115acyl-CoA biosynthetic process (GO:0071616)2.98395303
116thioester biosynthetic process (GO:0035384)2.98395303
117tyrosine metabolic process (GO:0006570)2.98215579
118regulation of cholesterol metabolic process (GO:0090181)2.97886259
119myeloid cell activation involved in immune response (GO:0002275)2.97236496
120positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.96575611
121ethanol oxidation (GO:0006069)2.96454455
122regulation of regulatory T cell differentiation (GO:0045589)2.95402295
123positive regulation of B cell differentiation (GO:0045579)2.94440430
124positive regulation of T cell mediated cytotoxicity (GO:0001916)2.94420284
125cholesterol efflux (GO:0033344)2.93584083
126plasma lipoprotein particle organization (GO:0071827)2.93494622
127phospholipid efflux (GO:0033700)2.93021348
128linoleic acid metabolic process (GO:0043651)2.92596205
129acetyl-CoA metabolic process (GO:0006084)2.92060895
130plasma lipoprotein particle assembly (GO:0034377)2.90832601
131cellular glucuronidation (GO:0052695)2.90697620
132microglial cell activation (GO:0001774)2.90327963
133response to host immune response (GO:0052572)2.89608858
134response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.89608858
135negative regulation of cholesterol transport (GO:0032375)2.89486945
136negative regulation of sterol transport (GO:0032372)2.89486945
137regulation of interferon-alpha production (GO:0032647)2.88891111
138urea cycle (GO:0000050)2.88483942
139urea metabolic process (GO:0019627)2.88483942
140detection of biotic stimulus (GO:0009595)2.87392049
141serine family amino acid biosynthetic process (GO:0009070)2.87219267
142heme transport (GO:0015886)2.86701276
143negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.86576549
144negative regulation of astrocyte differentiation (GO:0048712)2.86484659
145L-serine metabolic process (GO:0006563)2.86185765
146interferon-gamma-mediated signaling pathway (GO:0060333)2.85257569
147regulation of alpha-beta T cell proliferation (GO:0046640)2.84942513
148regulation of B cell differentiation (GO:0045577)2.83877760
149cellular response to cholesterol (GO:0071397)2.83709750
150regulation of fibrinolysis (GO:0051917)2.83670807
151regulation of mast cell degranulation (GO:0043304)2.83099317
152regulation of bile acid biosynthetic process (GO:0070857)2.82771595
153T cell selection (GO:0045058)2.81292851
154macrophage activation (GO:0042116)2.80760476
155protein-lipid complex subunit organization (GO:0071825)2.79101197
156plasma lipoprotein particle clearance (GO:0034381)2.78346599
157protein carboxylation (GO:0018214)2.77067140
158peptidyl-glutamic acid carboxylation (GO:0017187)2.77067140
159fatty-acyl-CoA metabolic process (GO:0035337)2.76747145
160drug catabolic process (GO:0042737)2.76532092
161negative regulation of fibrinolysis (GO:0051918)2.75767954
162positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.75514809
163nitrogen cycle metabolic process (GO:0071941)2.75169980
164purine nucleotide transport (GO:0015865)2.75003495
165dicarboxylic acid catabolic process (GO:0043649)2.74679863
166regulation of protein activation cascade (GO:2000257)2.74257739
167organic acid catabolic process (GO:0016054)2.73947013
168carboxylic acid catabolic process (GO:0046395)2.73947013
169acyl-CoA metabolic process (GO:0006637)2.73331181
170thioester metabolic process (GO:0035383)2.73331181
171regulation of interleukin-12 biosynthetic process (GO:0045075)2.72468342
172regulation of T cell tolerance induction (GO:0002664)2.71897823
173complement activation, alternative pathway (GO:0006957)2.70846892
174positive T cell selection (GO:0043368)2.70761901
175L-serine transport (GO:0015825)2.70446993
176NIK/NF-kappaB signaling (GO:0038061)2.69612261
177negative regulation of innate immune response (GO:0045824)2.69174246
178regulation of cellular extravasation (GO:0002691)2.69129564
179regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.68735553
180regulation of natural killer cell mediated immunity (GO:0002715)2.68735553
181response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.67853032
182response to host (GO:0075136)2.67853032
183response to host defenses (GO:0052200)2.67853032
184thymic T cell selection (GO:0045061)2.67367898
185regulation of myeloid leukocyte mediated immunity (GO:0002886)2.67134845
186protein-lipid complex assembly (GO:0065005)2.66339706
187serine family amino acid metabolic process (GO:0009069)2.66198784
188regulation of leukocyte mediated cytotoxicity (GO:0001910)2.66164058
189tolerance induction (GO:0002507)2.64552811
190lipopolysaccharide-mediated signaling pathway (GO:0031663)2.64258169
191defense response to protozoan (GO:0042832)2.63414618
192negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.62706246
193negative regulation of T-helper cell differentiation (GO:0045623)2.62706246
194regulation of tolerance induction (GO:0002643)2.62273068
195positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.61753464
196positive regulation of toll-like receptor signaling pathway (GO:0034123)2.61729271
197negative regulation of glycoprotein biosynthetic process (GO:0010561)2.61514393
198regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.60979949
199leukocyte degranulation (GO:0043299)2.60400595
200regulation of mast cell activation involved in immune response (GO:0033006)2.57523826

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.30725223
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.29095329
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.07038970
4IRF8_21731497_ChIP-ChIP_J774_Mouse4.04979498
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.83086507
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.74240460
7RXR_22158963_ChIP-Seq_LIVER_Mouse3.67504995
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.39554914
9BP1_19119308_ChIP-ChIP_Hs578T_Human3.27837094
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.14955560
11LXR_22158963_ChIP-Seq_LIVER_Mouse3.11830680
12SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.10135799
13IRF8_27001747_Chip-Seq_BMDM_Mouse2.96865624
14PPARA_22158963_ChIP-Seq_LIVER_Mouse2.94320363
15EGR1_23403033_ChIP-Seq_LIVER_Mouse2.90387713
16STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.73741882
17MYB_26560356_Chip-Seq_TH2_Human2.73362377
18NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.68847525
19RUNX_20019798_ChIP-Seq_JUKART_Human2.67951135
20FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.64237156
21SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.63617953
22GBX2_23144817_ChIP-Seq_PC3_Human2.61749104
23MYB_21317192_ChIP-Seq_ERMYB_Mouse2.58164593
24SPI1_23547873_ChIP-Seq_NB4_Human2.56355551
25STAT4_19710469_ChIP-ChIP_TH1__Mouse2.41260317
26* MYB_26560356_Chip-Seq_TH1_Human2.24453415
27SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.21362440
28RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.18725527
29FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.11967004
30NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.11273328
31E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.09187265
32MAF_26560356_Chip-Seq_TH1_Human2.07902343
33* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.04890927
34SPI1_23127762_ChIP-Seq_K562_Human2.01244686
35EZH2_22144423_ChIP-Seq_EOC_Human1.98110267
36SCL_19346495_ChIP-Seq_HPC-7_Human1.96689817
37BRD4_27068464_Chip-Seq_AML-cells_Mouse1.95496437
38RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.93662816
39VDR_24763502_ChIP-Seq_THP-1_Human1.92110386
40NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.92040947
41* GATA3_27048872_Chip-Seq_THYMUS_Human1.91518781
42RUNX1_22412390_ChIP-Seq_EML_Mouse1.91285419
43Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.90063152
44* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.86799435
45UTX_26944678_Chip-Seq_JUKART_Human1.85879591
46* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.85661189
47ELF1_17652178_ChIP-ChIP_JURKAT_Human1.83544237
48* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.77809687
49MYC_22102868_ChIP-Seq_BL_Human1.76779702
50JARID2_20064375_ChIP-Seq_MESCs_Mouse1.75982994
51AR_21572438_ChIP-Seq_LNCaP_Human1.75163041
52SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.73366411
53EZH2_18974828_ChIP-Seq_MESCs_Mouse1.73110096
54RNF2_18974828_ChIP-Seq_MESCs_Mouse1.73110096
55SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.72967507
56SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.71197172
57* EED_16625203_ChIP-ChIP_MESCs_Mouse1.70035255
58VDR_21846776_ChIP-Seq_THP-1_Human1.70007657
59GATA3_26560356_Chip-Seq_TH2_Human1.69750955
60PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.66095198
61PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.65417136
62* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.64798314
63CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.64271340
64JARID2_20075857_ChIP-Seq_MESCs_Mouse1.61763157
65TAF15_26573619_Chip-Seq_HEK293_Human1.61216767
66EGR1_19374776_ChIP-ChIP_THP-1_Human1.61145284
67HTT_18923047_ChIP-ChIP_STHdh_Human1.60969801
68MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.58435726
69GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.58138186
70STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.55985398
71SMAD_19615063_ChIP-ChIP_OVARY_Human1.54523649
72DROSHA_22980978_ChIP-Seq_HELA_Human1.53086963
73EZH2_27294783_Chip-Seq_ESCs_Mouse1.52281313
74LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.51539659
75SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.50345508
76* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.48005661
77CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.47114123
78SUZ12_27294783_Chip-Seq_ESCs_Mouse1.47094785
79REST_21632747_ChIP-Seq_MESCs_Mouse1.45307142
80EZH2_27304074_Chip-Seq_ESCs_Mouse1.44280141
81SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.43922583
82PIAS1_25552417_ChIP-Seq_VCAP_Human1.42185161
83NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.40300729
84LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.40176532
85CDX2_19796622_ChIP-Seq_MESCs_Mouse1.40033964
86ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.39623874
87MAF_26560356_Chip-Seq_TH2_Human1.38529071
88CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.36866385
89VDR_24787735_ChIP-Seq_THP-1_Human1.36632372
90CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.36053372
91RNF2_27304074_Chip-Seq_ESCs_Mouse1.30876296
92GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28517561
93GATA1_22025678_ChIP-Seq_K562_Human1.28462319
94PU_27001747_Chip-Seq_BMDM_Mouse1.26263515
95TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.23580153
96SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.23548917
97ERG_21242973_ChIP-ChIP_JURKAT_Human1.22275872
98CTBP2_25329375_ChIP-Seq_LNCAP_Human1.22117333
99GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.21228342
100* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.21027076
101ZFP57_27257070_Chip-Seq_ESCs_Mouse1.20886833
102GATA1_22383799_ChIP-Seq_G1ME_Mouse1.19848633
103* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.19362601
104PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.18827559
105VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.17764534
106P300_19829295_ChIP-Seq_ESCs_Human1.17141970
107REST_18959480_ChIP-ChIP_MESCs_Mouse1.16433887
108GATA1_19941827_ChIP-Seq_MEL_Mouse1.15454754
109OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15360130
110TCF7_22412390_ChIP-Seq_EML_Mouse1.14987999
111FOXA2_19822575_ChIP-Seq_HepG2_Human1.14036860
112* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.13265057
113PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.11772530
114NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.10287297
115NRF2_20460467_ChIP-Seq_MEFs_Mouse1.10287297
116CIITA_25753668_ChIP-Seq_RAJI_Human1.09106693
117CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.09053038
118CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.08619650
119PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08593445
120SMAD4_21799915_ChIP-Seq_A2780_Human1.08344005
121RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.08030278
122NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.07622093
123AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.07146043
124THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.06278612
125BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.05905440
126PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.05593653
127NR3C1_21868756_ChIP-Seq_MCF10A_Human1.05433580
128SMAD3_21741376_ChIP-Seq_EPCs_Human1.05014492
129BCAT_22108803_ChIP-Seq_LS180_Human1.02971365
130* CBX2_27304074_Chip-Seq_ESCs_Mouse1.02803100
131NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.02800291
132HOXB4_20404135_ChIP-ChIP_EML_Mouse1.02255603
133PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02217041
134SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.01836356
135RARB_27405468_Chip-Seq_BRAIN_Mouse1.01559005
136GATA1_19941826_ChIP-Seq_K562_Human1.01447531
137* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01368668
138SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.00575948
139PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.98745657
140MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.97247597
141SOX2_27498859_Chip-Seq_STOMACH_Mouse0.97107109
142SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.96236654
143RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.95772870
144* PU.1_20513432_ChIP-Seq_Bcells_Mouse0.95692886
145TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.94956190
146UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.94064406
147TFEB_21752829_ChIP-Seq_HELA_Human0.93833999
148AR_25329375_ChIP-Seq_VCAP_Human0.93472000
149STAT3_23295773_ChIP-Seq_U87_Human0.93283630
150TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.91028159
151NR3C1_23031785_ChIP-Seq_PC12_Mouse0.90088979
152KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.90084689
153GATA2_19941826_ChIP-Seq_K562_Human0.90069113
154* BCL6_27268052_Chip-Seq_Bcells_Human0.89564091
155ESR2_21235772_ChIP-Seq_MCF-7_Human0.88516410
156ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.88428706
157ER_23166858_ChIP-Seq_MCF-7_Human0.88402100
158ZNF217_24962896_ChIP-Seq_MCF-7_Human0.88214420
159TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.87613693
160* POU3F2_20337985_ChIP-ChIP_501MEL_Human0.87590451
161TOP2B_26459242_ChIP-Seq_MCF-7_Human0.87039569
162TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.86995197
163GATA2_21666600_ChIP-Seq_HMVEC_Human0.86285418
164FOXO3_23340844_ChIP-Seq_DLD1_Human0.86251976
165AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.86107622
166ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.85946082
167SOX2_21211035_ChIP-Seq_LN229_Gbm0.85694473
168KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.84137951
169RXR_22108803_ChIP-Seq_LS180_Human0.84118292
170BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.83643966
171RING1B_27294783_Chip-Seq_ESCs_Mouse0.83398577
172BCOR_27268052_Chip-Seq_Bcells_Human0.82806046
173* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81697447
174NCOR1_26117541_ChIP-Seq_K562_Human0.81594824
175SMAD4_21741376_ChIP-Seq_EPCs_Human0.79878807
176NOTCH1_21737748_ChIP-Seq_TLL_Human0.79029319
177WT1_25993318_ChIP-Seq_PODOCYTE_Human0.78291012
178TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.78231346
179EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.78184077
180IKZF1_21737484_ChIP-ChIP_HCT116_Human0.78165074
181SMAD4_21741376_ChIP-Seq_HESCs_Human0.77710778
182ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.77350425
183ERG_20887958_ChIP-Seq_HPC-7_Mouse0.77227147
184NANOG_18555785_Chip-Seq_ESCs_Mouse0.77227121
185EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.76981953
186VDR_22108803_ChIP-Seq_LS180_Human0.76787587
187MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.76640619
188AUTS2_25519132_ChIP-Seq_293T-REX_Human0.75523345
189CBP_21632823_ChIP-Seq_H3396_Human0.74936347
190MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.74618426
191PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.74224883
192AR_19668381_ChIP-Seq_PC3_Human0.73920940

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.34437540
2MP0005360_urolithiasis5.00962192
3MP0003724_increased_susceptibility_to3.79505055
4MP0005085_abnormal_gallbladder_physiolo3.79367429
5MP0005365_abnormal_bile_salt3.67899637
6MP0003436_decreased_susceptibility_to3.54212164
7MP0001835_abnormal_antigen_presentation3.49693174
8MP0008875_abnormal_xenobiotic_pharmacok3.44961670
9MP0003806_abnormal_nucleotide_metabolis3.29118247
10MP0005671_abnormal_response_to3.07001776
11MP0003690_abnormal_glial_cell3.05408653
12MP0000685_abnormal_immune_system2.90616861
13MP0001800_abnormal_humoral_immune2.82115794
14MP0003329_amyloid_beta_deposits2.79325398
15MP0009785_altered_susceptibility_to2.69062099
16MP0005000_abnormal_immune_tolerance2.66370763
17MP0005332_abnormal_amino_acid2.61559784
18MP0003303_peritoneal_inflammation2.56971136
19MP0001790_abnormal_immune_system2.55966253
20MP0005387_immune_system_phenotype2.55966253
21MP0003763_abnormal_thymus_physiology2.52369157
22MP0005025_abnormal_response_to2.51740566
23MP0002419_abnormal_innate_immunity2.50385998
24MP0009840_abnormal_foam_cell2.49908535
25MP0002723_abnormal_immune_serum2.45466026
26MP0010329_abnormal_lipoprotein_level2.39239099
27MP0002452_abnormal_antigen_presenting2.35934528
28MP0002420_abnormal_adaptive_immunity2.29832695
29MP0010155_abnormal_intestine_physiology2.29200969
30MP0001819_abnormal_immune_cell2.27821461
31MP0002148_abnormal_hypersensitivity_rea2.25382886
32MP0006082_CNS_inflammation2.18371848
33MP0004885_abnormal_endolymph2.16885079
34MP0003300_gastrointestinal_ulcer2.13275200
35MP0003866_abnormal_defecation2.09780344
36MP0003252_abnormal_bile_duct2.05465404
37MP0003195_calcinosis2.00254119
38MP0004859_abnormal_synaptic_plasticity1.99555713
39MP0003183_abnormal_peptide_metabolism1.95297848
40MP0000604_amyloidosis1.91356490
41MP0000920_abnormal_myelination1.91266483
42MP0004270_analgesia1.86687229
43MP0005464_abnormal_platelet_physiology1.86273345
44MP0002405_respiratory_system_inflammati1.84329576
45MP0002398_abnormal_bone_marrow1.83263128
46MP0001845_abnormal_inflammatory_respons1.82272717
47MP0002166_altered_tumor_susceptibility1.80052566
48MP0001486_abnormal_startle_reflex1.79793573
49MP0001666_abnormal_nutrient_absorption1.79472349
50MP0000716_abnormal_immune_system1.79209480
51MP0000465_gastrointestinal_hemorrhage1.78258400
52MP0001533_abnormal_skeleton_physiology1.76120752
53MP0003136_yellow_coat_color1.74383463
54MP0003880_abnormal_central_pattern1.72687446
55MP0009333_abnormal_splenocyte_physiolog1.71536718
56MP0004947_skin_inflammation1.70178376
57MP0009046_muscle_twitch1.64587579
58MP0002118_abnormal_lipid_homeostasis1.63378345
59MP0005058_abnormal_lysosome_morphology1.63311064
60MP0002064_seizures1.62146709
61MP0003172_abnormal_lysosome_physiology1.61566918
62MP0000689_abnormal_spleen_morphology1.59115582
63MP0004019_abnormal_vitamin_homeostasis1.57676872
64MP0005083_abnormal_biliary_tract1.57633500
65MP0009745_abnormal_behavioral_response1.56678417
66MP0002722_abnormal_immune_system1.55088907
67MP0002396_abnormal_hematopoietic_system1.54620748
68MP0003635_abnormal_synaptic_transmissio1.53248039
69MP0008469_abnormal_protein_level1.51792063
70MP0003011_delayed_dark_adaptation1.49887587
71MP0001440_abnormal_grooming_behavior1.48156774
72MP0004043_abnormal_pH_regulation1.47378340
73MP0005584_abnormal_enzyme/coenzyme_acti1.44991611
74MP0005646_abnormal_pituitary_gland1.44708017
75MP0002429_abnormal_blood_cell1.43903210
76MP0002272_abnormal_nervous_system1.43777930
77MP0008260_abnormal_autophagy1.43474145
78MP0002009_preneoplasia1.43288273
79MP0005310_abnormal_salivary_gland1.42743591
80MP0002822_catalepsy1.38120975
81MP0000703_abnormal_thymus_morphology1.35035287
82MP0005451_abnormal_body_composition1.33123726
83MP0003868_abnormal_feces_composition1.32145587
84MP0002254_reproductive_system_inflammat1.31814555
85MP0002572_abnormal_emotion/affect_behav1.31661968
86MP0002132_abnormal_respiratory_system1.31616650
87MP0009384_cardiac_valve_regurgitation1.31188457
88MP0002138_abnormal_hepatobiliary_system1.31013774
89MP0001984_abnormal_olfaction1.29937552
90MP0001873_stomach_inflammation1.29628241
91MP0003634_abnormal_glial_cell1.28534507
92MP0002006_tumorigenesis1.28515426
93MP0004142_abnormal_muscle_tone1.26618034
94MP0001485_abnormal_pinna_reflex1.26386535
95MP0001905_abnormal_dopamine_level1.24405999
96MP0005551_abnormal_eye_electrophysiolog1.24027471
97MP0000858_altered_metastatic_potential1.22896088
98MP0010234_abnormal_vibrissa_follicle1.21779892
99MP0002063_abnormal_learning/memory/cond1.21618448
100MP0009780_abnormal_chondrocyte_physiolo1.20358738
101MP0003632_abnormal_nervous_system1.20092039
102MP0003633_abnormal_nervous_system1.19848823
103MP0005423_abnormal_somatic_nervous1.18888473
104MP0001502_abnormal_circadian_rhythm1.17873759
105MP0004742_abnormal_vestibular_system1.13849709
106MP0003631_nervous_system_phenotype1.12888446
107MP0003828_pulmonary_edema1.12702985
108MP0003878_abnormal_ear_physiology1.11108151
109MP0005377_hearing/vestibular/ear_phenot1.11108151
110MP0002229_neurodegeneration1.09108859
111MP0003075_altered_response_to1.08338653
112MP0009697_abnormal_copulation1.07938573
113MP0005171_absent_coat_pigmentation1.06669639
114MP0002277_abnormal_respiratory_mucosa1.06583677
115MP0004858_abnormal_nervous_system1.06295722
116MP0005166_decreased_susceptibility_to1.04256226
117MP0001661_extended_life_span1.03555159
118MP0005075_abnormal_melanosome_morpholog1.03271682
119MP0001501_abnormal_sleep_pattern1.03250025
120MP0002734_abnormal_mechanical_nocicepti1.02724261
121MP0000609_abnormal_liver_physiology1.02571856
122MP0004381_abnormal_hair_follicle1.01343370
123MP0002067_abnormal_sensory_capabilities0.99962218
124MP0003191_abnormal_cellular_cholesterol0.99958493
125MP0005647_abnormal_sex_gland0.99458530
126MP0001529_abnormal_vocalization0.99289981
127MP0000569_abnormal_digit_pigmentation0.96077730
128MP0004264_abnormal_extraembryonic_tissu0.95149974
129MP0002998_abnormal_bone_remodeling0.94913711
130MP0000566_synostosis0.94118555
131MP0003656_abnormal_erythrocyte_physiolo0.93992588
132MP0009763_increased_sensitivity_to0.93838534
133MP0000490_abnormal_crypts_of0.93164958
134MP0001968_abnormal_touch/_nociception0.92970857
135MP0000015_abnormal_ear_pigmentation0.92516197
136MP0005535_abnormal_body_temperature0.91678248
137MP0002736_abnormal_nociception_after0.91158342
138MP0005386_behavior/neurological_phenoty0.90949582
139MP0004924_abnormal_behavior0.90949582
140MP0005670_abnormal_white_adipose0.90463555
141MP0005319_abnormal_enzyme/_coenzyme0.88221455
142MP0005164_abnormal_response_to0.86624215
143MP0009278_abnormal_bone_marrow0.86575527
144MP0001851_eye_inflammation0.86169002
145MP0003045_fibrosis0.86049890
146MP0001853_heart_inflammation0.85882347
147MP0004883_abnormal_blood_vessel0.85602312
148MP0008569_lethality_at_weaning0.85415756
149MP0001663_abnormal_digestive_system0.85053619
150MP0002090_abnormal_vision0.84423701
151MP0009643_abnormal_urine_homeostasis0.83073837
152MP0001545_abnormal_hematopoietic_system0.82980403
153MP0005397_hematopoietic_system_phenotyp0.82980403
154MP0000778_abnormal_nervous_system0.82042074
155MP0002557_abnormal_social/conspecific_i0.80898340
156MP0002066_abnormal_motor_capabilities/c0.78951727
157MP0001963_abnormal_hearing_physiology0.78791357
158MP0001765_abnormal_ion_homeostasis0.77941379
159MP0002733_abnormal_thermal_nociception0.77277780
160MP0001764_abnormal_homeostasis0.77058532
161MP0002876_abnormal_thyroid_physiology0.72726192
162MP0000955_abnormal_spinal_cord0.72059280
163MP0009764_decreased_sensitivity_to0.70469860
164MP0002882_abnormal_neuron_morphology0.70266171
165MP0004147_increased_porphyrin_level0.70063609
166MP0008874_decreased_physiological_sensi0.69931830
167MP0003186_abnormal_redox_activity0.67581999
168MP0002693_abnormal_pancreas_physiology0.67351437
169MP0009765_abnormal_xenobiotic_induced0.67195879
170MP0002971_abnormal_brown_adipose0.67000244
171MP0005645_abnormal_hypothalamus_physiol0.66754907
172MP0004808_abnormal_hematopoietic_stem0.66349303
173MP0002136_abnormal_kidney_physiology0.66276164
174MP0001970_abnormal_pain_threshold0.66192225
175MP0003448_altered_tumor_morphology0.65864050
176MP0000462_abnormal_digestive_system0.64291841
177MP0005410_abnormal_fertilization0.64081082
178MP0000639_abnormal_adrenal_gland0.63898793

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)5.65730939
2Intrahepatic cholestasis (HP:0001406)5.29630455
3Abnormality of aromatic amino acid family metabolism (HP:0004338)4.83246016
4Recurrent abscess formation (HP:0002722)4.77346056
5Recurrent bacterial skin infections (HP:0005406)4.71903124
6Hyperlipoproteinemia (HP:0010980)4.66278588
7Xanthomatosis (HP:0000991)4.60101485
8Neurofibrillary tangles (HP:0002185)4.53169381
9Deep venous thrombosis (HP:0002625)4.44998018
10Myositis (HP:0100614)4.41545101
11Abnormality of macrophages (HP:0004311)4.38414289
12Orchitis (HP:0100796)4.22567701
13Prolonged partial thromboplastin time (HP:0003645)4.02020668
14Optic neuritis (HP:0100653)4.00635400
15Retrobulbar optic neuritis (HP:0100654)4.00635400
16Abnormality of glycine metabolism (HP:0010895)3.96587785
17Abnormality of serine family amino acid metabolism (HP:0010894)3.96587785
18Hyperglycinuria (HP:0003108)3.86452803
19Recurrent fungal infections (HP:0002841)3.79536594
20Hyperglycinemia (HP:0002154)3.68028815
21Stomatitis (HP:0010280)3.66893045
22Hypobetalipoproteinemia (HP:0003563)3.66217108
23Recurrent gram-negative bacterial infections (HP:0005420)3.63375835
24Chronic obstructive pulmonary disease (HP:0006510)3.61874626
25Obstructive lung disease (HP:0006536)3.61874626
26T lymphocytopenia (HP:0005403)3.59951902
27Meningitis (HP:0001287)3.58875320
28Abnormality of monocarboxylic acid metabolism (HP:0010996)3.51907291
29Elevated erythrocyte sedimentation rate (HP:0003565)3.49886347
30Abnormality of T cell number (HP:0011839)3.45780426
31Mediastinal lymphadenopathy (HP:0100721)3.45066421
32Ketosis (HP:0001946)3.39129214
33Cerebral inclusion bodies (HP:0100314)3.37427460
34Gastrointestinal infarctions (HP:0005244)3.36451188
35Hyperammonemia (HP:0001987)3.35319538
36Encephalitis (HP:0002383)3.30288071
37Abnormal delayed hypersensitivity skin test (HP:0002963)3.27182794
38Abnormality of aspartate family amino acid metabolism (HP:0010899)3.22323381
39Vasculitis (HP:0002633)3.20906202
40Recurrent skin infections (HP:0001581)3.20533992
41Aplasia involving bones of the extremities (HP:0009825)3.18154092
42Aplasia involving bones of the upper limbs (HP:0009823)3.18154092
43Aplasia of the phalanges of the hand (HP:0009802)3.18154092
44Hypolipoproteinemia (HP:0010981)3.15296054
45Abnormality of sulfur amino acid metabolism (HP:0004339)3.15180928
46Abnormality of methionine metabolism (HP:0010901)3.13836591
47Hypoalphalipoproteinemia (HP:0003233)3.11030082
48Chronic diarrhea (HP:0002028)3.10472827
49Chronic mucocutaneous candidiasis (HP:0002728)3.05020634
50Recurrent cutaneous fungal infections (HP:0011370)3.05020634
51Abnormality of T cells (HP:0002843)3.01170650
52Recurrent viral infections (HP:0004429)3.00456092
53Spontaneous hematomas (HP:0007420)2.99533002
54Pustule (HP:0200039)2.95060859
55Keratoconjunctivitis sicca (HP:0001097)2.94899551
56Abnormality of glutamine family amino acid metabolism (HP:0010902)2.93802362
57Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.93628240
58Pulmonary infiltrates (HP:0002113)2.92189798
59Keratoconjunctivitis (HP:0001096)2.90380060
60Ketoacidosis (HP:0001993)2.87625652
61Gingivitis (HP:0000230)2.85905883
62Fat malabsorption (HP:0002630)2.85851678
63Inflammation of the large intestine (HP:0002037)2.84275750
64Complement deficiency (HP:0004431)2.81988146
65Gingival bleeding (HP:0000225)2.81746242
66Agammaglobulinemia (HP:0004432)2.78887500
67Urticaria (HP:0001025)2.76774423
68Epidermoid cyst (HP:0200040)2.73981075
69Spastic paraparesis (HP:0002313)2.73854041
70Granulocytopenia (HP:0001913)2.73517584
71Osteomyelitis (HP:0002754)2.73506749
72Confusion (HP:0001289)2.71822338
73Gastrointestinal inflammation (HP:0004386)2.71087253
74Increased IgM level (HP:0003496)2.66961604
75Recurrent bronchitis (HP:0002837)2.65297401
76Abnormality of T cell physiology (HP:0011840)2.61517163
77Cellulitis (HP:0100658)2.61391043
78Leukocytosis (HP:0001974)2.60929477
79Hemoptysis (HP:0002105)2.59854426
80Joint hemorrhage (HP:0005261)2.59587432
81Increased IgE level (HP:0003212)2.59098968
82Megalencephaly (HP:0001355)2.57047247
83Petechiae (HP:0000967)2.57011657
84Prolonged bleeding time (HP:0003010)2.56355324
85Status epilepticus (HP:0002133)2.50880534
86Panhypogammaglobulinemia (HP:0003139)2.50819347
87Anorexia (HP:0002039)2.50372019
88Premature loss of primary teeth (HP:0006323)2.49354440
89Amyloidosis (HP:0011034)2.48577203
90Chest pain (HP:0100749)2.47322571
91Paraparesis (HP:0002385)2.47125474
92Hyperventilation (HP:0002883)2.44816357
93Delayed CNS myelination (HP:0002188)2.43757105
94Epistaxis (HP:0000421)2.43058870
95Abnormality of liposaccharide metabolism (HP:0010968)2.42917195
96Abnormality of glycosphingolipid metabolism (HP:0004343)2.42917195
97Abnormality of glycolipid metabolism (HP:0010969)2.42917195
98Pulmonary embolism (HP:0002204)2.42247018
99Autoimmune hemolytic anemia (HP:0001890)2.41959554
100Conjugated hyperbilirubinemia (HP:0002908)2.41361225
101Severe combined immunodeficiency (HP:0004430)2.41197390
102Abnormality of secondary sexual hair (HP:0009888)2.40564167
103Abnormality of the axillary hair (HP:0100134)2.40564167
104Synostosis involving the elbow (HP:0003938)2.38785457
105Humeroradial synostosis (HP:0003041)2.38785457
106Dysostosis multiplex (HP:0000943)2.37950198
107Colitis (HP:0002583)2.37799318
108Arterial thrombosis (HP:0004420)2.37378365
109IgG deficiency (HP:0004315)2.35478153
110Myokymia (HP:0002411)2.34789376
111Vacuolated lymphocytes (HP:0001922)2.33240408
112Gangrene (HP:0100758)2.31646370
113Methylmalonic acidemia (HP:0002912)2.31398339
114Hypoglycemic coma (HP:0001325)2.31319388
115Abnormality of fatty-acid metabolism (HP:0004359)2.30836816
116Acute hepatic failure (HP:0006554)2.30677440
117Eosinophilia (HP:0001880)2.29364208
118Steatorrhea (HP:0002570)2.28921407
119Focal motor seizures (HP:0011153)2.27934202
120Increased circulating renin level (HP:0000848)2.27156376
121Vascular calcification (HP:0004934)2.25846902
122Malnutrition (HP:0004395)2.25058536
123Systemic lupus erythematosus (HP:0002725)2.23882057
124Abnormality of serum amino acid levels (HP:0003112)2.22969630
125Joint swelling (HP:0001386)2.20646903
126Intention tremor (HP:0002080)2.19794039
127Abnormality of the pleura (HP:0002103)2.19668579
128Sensorimotor neuropathy (HP:0007141)2.19328579
129Methylmalonic aciduria (HP:0012120)2.18738457
130Purpura (HP:0000979)2.18176062
131Abnormality of eosinophils (HP:0001879)2.18009326
132Hypercholesterolemia (HP:0003124)2.17910665
133Supranuclear gaze palsy (HP:0000605)2.17341457
134Loss of speech (HP:0002371)2.16752932
135Lethargy (HP:0001254)2.15652794
136Combined immunodeficiency (HP:0005387)2.14281082
137Episodic fever (HP:0001954)2.14053554
138Increased cerebral lipofuscin (HP:0011813)2.12917443
139Abnormality of B cell number (HP:0010975)2.11862863
140Dicarboxylic aciduria (HP:0003215)2.11559081
141Abnormality of dicarboxylic acid metabolism (HP:0010995)2.11559081
142Sepsis (HP:0100806)2.10882145
143Gout (HP:0001997)2.10026944
144Hematochezia (HP:0002573)2.09830964
145Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.09473270
146Degeneration of the lateral corticospinal tracts (HP:0002314)2.09473270
147Hepatosplenomegaly (HP:0001433)2.08649688
148Skin rash (HP:0000988)2.08609150
149Metabolic acidosis (HP:0001942)2.08002850
150Mucopolysacchariduria (HP:0008155)2.07814648
151Urinary glycosaminoglycan excretion (HP:0003541)2.07814648
152Clumsiness (HP:0002312)2.07584772
153IgM deficiency (HP:0002850)2.05576776
154Chronic otitis media (HP:0000389)2.04572899
155Recurrent sinusitis (HP:0011108)2.03644073
156Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.03321445
157Abnormality of the common coagulation pathway (HP:0010990)2.03272171
158Irritability (HP:0000737)2.03204557
159Recurrent pneumonia (HP:0006532)2.02504597
160Abnormality of mucopolysaccharide metabolism (HP:0011020)2.02427633
161Abnormality of polysaccharide metabolism (HP:0011012)2.02427633
162Abnormality of glycosaminoglycan metabolism (HP:0004371)2.02427633
163Back pain (HP:0003418)2.01690063
164Parakeratosis (HP:0001036)1.98886011
165Abnormal gallbladder physiology (HP:0012438)1.98635370
166Cholecystitis (HP:0001082)1.98635370
167Abnormality of the corticospinal tract (HP:0002492)1.97503142
168Hyperbilirubinemia (HP:0002904)1.97275508
169Lymphopenia (HP:0001888)1.97003387
170Papilloma (HP:0012740)1.96914090
171Verrucae (HP:0200043)1.96914090
172Hemiparesis (HP:0001269)1.96207690
173Hypergammaglobulinemia (HP:0010702)1.95103783
174Hypoplastic left heart (HP:0004383)1.94908039
175Hypochromic anemia (HP:0001931)1.93969406
176Fatigue (HP:0012378)1.93917729
177Abnormality of vitamin metabolism (HP:0100508)1.93719762
178Increased neuronal autofluorescent lipopigment (HP:0002074)1.92485216
179Metabolic alkalosis (HP:0200114)1.91797333
180Alkalosis (HP:0001948)1.91438431
181Cardiovascular calcification (HP:0011915)1.89072964
182Hypophosphatemic rickets (HP:0004912)1.88616235
183Hemiplegia (HP:0002301)1.87872803
184Hypokalemic alkalosis (HP:0001949)1.86702571
185Enlarged kidneys (HP:0000105)1.85201676
186Abnormal gallbladder morphology (HP:0012437)1.83265480
187Abnormality of glycolysis (HP:0004366)1.83228267
188Increased serum pyruvate (HP:0003542)1.83228267
189Dysmetria (HP:0001310)1.79435353
190Diplopia (HP:0000651)1.79362150
191Abnormality of binocular vision (HP:0011514)1.79362150
192Pheochromocytoma (HP:0002666)1.78697865
193Abnormality of purine metabolism (HP:0004352)1.77756903
194Rickets (HP:0002748)1.76579424
195Abnormality of urine glucose concentration (HP:0011016)1.76415875
196Glycosuria (HP:0003076)1.76415875
197Hypoglycemic seizures (HP:0002173)1.75795738
198Cerebral edema (HP:0002181)1.75634684
199Spastic tetraparesis (HP:0001285)1.72725572
200Dysdiadochokinesis (HP:0002075)1.71788260

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA43.67034571
2MAP4K13.65105295
3TNIK3.59339793
4STK393.52496978
5ERN13.40252218
6RIPK43.34297123
7OXSR13.31886353
8IRAK43.16857238
9TXK3.05354668
10TYK22.97663808
11MAP3K142.70049201
12BLK2.66196699
13MUSK2.59636936
14BCKDK2.40677157
15NTRK22.21856193
16CSK2.14776170
17PHKG22.07962430
18PHKG12.07962430
19ACVR1B2.05948905
20MAP2K32.05353542
21SIK11.96625401
22CASK1.92239417
23IKBKE1.88886606
24JAK31.86888920
25ZAP701.83738664
26LMTK21.82770115
27TESK21.81287639
28EPHB11.81102780
29TBK11.80718761
30WNK41.79052318
31BTK1.72649343
32SYK1.72099079
33NTRK11.63543053
34PBK1.61955412
35JAK11.60488784
36NTRK31.59389596
37SGK2231.58275224
38SGK4941.58275224
39ERBB41.57207122
40FGFR21.54405248
41PKN11.51380043
42INSRR1.48214453
43LYN1.46491369
44ITK1.44571997
45MAP3K21.41856409
46CSF1R1.41722655
47BMPR21.41490747
48HCK1.40934204
49MAP3K31.37574695
50MAP3K41.36562429
51MAP3K11.34476030
52MAP2K21.34184312
53MAP2K41.32275077
54TAOK11.30701341
55PINK11.29440813
56IKBKB1.26293197
57PAK61.23811064
58JAK21.21284645
59PRPF4B1.19655703
60LCK1.18141998
61MAP3K131.17729989
62PRKD31.17010218
63MAP3K111.15683680
64ICK1.14502965
65EPHA31.14406668
66FGFR31.14394119
67NEK61.12456958
68TYRO31.11458076
69MAP2K71.11135054
70CSNK1G21.10794645
71NLK1.08862851
72MATK1.08172146
73MET1.08102421
74PRKCG1.05982313
75TEC1.04531198
76MAP3K121.03394317
77CAMK2G1.02294922
78MAP2K61.00749483
79WNK11.00329527
80MARK10.99889334
81STK100.98317698
82CAMKK20.97564563
83FGR0.96397772
84SIK30.95665919
85MAPK150.95477620
86CAMK2A0.94009995
87WNK30.93232049
88MAPK120.92709868
89IRAK20.91909162
90ARAF0.91908997
91BCR0.91735629
92MINK10.90917537
93PRKCQ0.90827731
94CDK50.90183595
95MAPK130.90108079
96CDK190.90058460
97PDPK10.89967263
98TAOK30.89349424
99CAMK2B0.88841334
100MARK30.87891789
101YES10.87761275
102PAK30.87515766
103DAPK20.87357130
104SGK20.85820894
105MAP3K90.82316620
106CSNK1G30.79775802
107PRKCE0.77574111
108CAMK2D0.77226204
109KIT0.76219968
110PIM10.75272499
111ROCK20.74220221
112MAPK70.73527910
113FGFR40.72414525
114SGK30.70593431
115CSNK1G10.70409156
116SCYL20.68890283
117FES0.68617737
118IRAK30.68598714
119PIK3CG0.66734832
120PRKCH0.64120074
121UHMK10.63799092
122CSNK1A1L0.61738445
123MAPKAPK50.61364665
124PRKCZ0.61353087
125PASK0.60681758
126MAP3K70.60635888
127CDK40.58939076
128PRKAA20.58758233
129CAMK1G0.57074472
130TNK20.55474672
131PDK10.55346923
132MELK0.55303513
133KSR20.55162973
134PRKACG0.55126551
135PTK60.55084402
136TAOK20.53662633
137MST40.53597525
138CDC42BPA0.53396583
139PNCK0.52809553
140PRKCA0.52687990
141PRKACA0.51576171
142CDK60.50916667
143PDK20.49786898
144IRAK10.49678701
145ADRBK10.49353897
146SGK10.49349649
147PRKG10.49300259
148STK380.48819285
149MAPK110.47566860
150MAPKAPK20.46956303
151FYN0.46735555
152DYRK1A0.44993705
153GRK60.44535811
154MST1R0.44489427
155GRK70.44373005
156RAF10.44322252
157HIPK20.43811713
158GRK50.43528936
159LRRK20.42786440
160CDK150.42233690
161PRKACB0.41673411
162PRKG20.41561380
163FRK0.41506592
164MARK20.41349513
165ABL20.40987641
166KDR0.38276732
167TGFBR20.37716114
168CDK120.37056214
169RPS6KA40.36555645
170CAMKK10.35009869
171NEK90.34657239
172MAP3K50.33774511
173DYRK1B0.28940212
174STK110.27540124
175ABL10.27496199
176MAP3K80.27216122

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.95321272
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.19364238
3Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.14731866
4Primary immunodeficiency_Homo sapiens_hsa053403.08769786
5Leishmaniasis_Homo sapiens_hsa051402.83198290
6Graft-versus-host disease_Homo sapiens_hsa053322.60310871
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.57684495
8Allograft rejection_Homo sapiens_hsa053302.56062596
9Osteoclast differentiation_Homo sapiens_hsa043802.53405394
10Steroid biosynthesis_Homo sapiens_hsa001002.52831331
11Butanoate metabolism_Homo sapiens_hsa006502.44091201
12Fatty acid degradation_Homo sapiens_hsa000712.41936383
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.35508476
14Autoimmune thyroid disease_Homo sapiens_hsa053202.34682257
15Fatty acid metabolism_Homo sapiens_hsa012122.32594092
16Fatty acid elongation_Homo sapiens_hsa000622.30456612
17NF-kappa B signaling pathway_Homo sapiens_hsa040642.25397143
18Arginine biosynthesis_Homo sapiens_hsa002202.23928160
19Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.20813345
20Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.20000173
21Propanoate metabolism_Homo sapiens_hsa006402.11670656
22Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.11350676
23Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.10898066
24B cell receptor signaling pathway_Homo sapiens_hsa046622.09976380
25Antigen processing and presentation_Homo sapiens_hsa046122.09699830
26Type I diabetes mellitus_Homo sapiens_hsa049402.08809544
27Intestinal immune network for IgA production_Homo sapiens_hsa046722.06315013
28Toll-like receptor signaling pathway_Homo sapiens_hsa046202.04545035
29Other glycan degradation_Homo sapiens_hsa005112.00839391
30Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.97821553
31Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.97533753
32Tryptophan metabolism_Homo sapiens_hsa003801.95327578
33NOD-like receptor signaling pathway_Homo sapiens_hsa046211.94055543
34Peroxisome_Homo sapiens_hsa041461.93358635
35Fatty acid biosynthesis_Homo sapiens_hsa000611.91214962
36Sulfur metabolism_Homo sapiens_hsa009201.89700580
37Tuberculosis_Homo sapiens_hsa051521.87575508
38Hematopoietic cell lineage_Homo sapiens_hsa046401.86708215
39Measles_Homo sapiens_hsa051621.83138261
40Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.80542991
41PPAR signaling pathway_Homo sapiens_hsa033201.77458121
42RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.76939692
43Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.72490672
44Bile secretion_Homo sapiens_hsa049761.71678768
45Complement and coagulation cascades_Homo sapiens_hsa046101.71272435
46Legionellosis_Homo sapiens_hsa051341.68944552
47Histidine metabolism_Homo sapiens_hsa003401.65346423
48T cell receptor signaling pathway_Homo sapiens_hsa046601.64265829
49Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.59004532
50Steroid hormone biosynthesis_Homo sapiens_hsa001401.51751906
51Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.51017362
52Herpes simplex infection_Homo sapiens_hsa051681.50875610
53Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.50832361
54Asthma_Homo sapiens_hsa053101.48599786
55Influenza A_Homo sapiens_hsa051641.47065122
56Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.45107595
57Chemical carcinogenesis_Homo sapiens_hsa052041.43053384
58Pentose and glucuronate interconversions_Homo sapiens_hsa000401.42914375
59beta-Alanine metabolism_Homo sapiens_hsa004101.42792114
60Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.41959865
61Toxoplasmosis_Homo sapiens_hsa051451.41556218
62Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.34115296
63Glycosaminoglycan degradation_Homo sapiens_hsa005311.30637378
64Pyruvate metabolism_Homo sapiens_hsa006201.28701360
65Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.28329675
66TNF signaling pathway_Homo sapiens_hsa046681.25708598
67Chemokine signaling pathway_Homo sapiens_hsa040621.23123706
68Retinol metabolism_Homo sapiens_hsa008301.23088252
69Arginine and proline metabolism_Homo sapiens_hsa003301.21750398
70Vitamin B6 metabolism_Homo sapiens_hsa007501.19284292
71Pertussis_Homo sapiens_hsa051331.18549997
72Hepatitis C_Homo sapiens_hsa051601.18271816
73Jak-STAT signaling pathway_Homo sapiens_hsa046301.17517616
74Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.16779299
75Acute myeloid leukemia_Homo sapiens_hsa052211.16554240
76Viral myocarditis_Homo sapiens_hsa054161.15970385
77Rheumatoid arthritis_Homo sapiens_hsa053231.12885567
78Malaria_Homo sapiens_hsa051441.02370992
79Vitamin digestion and absorption_Homo sapiens_hsa049771.02048992
80Hepatitis B_Homo sapiens_hsa051611.01813020
812-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.01598240
82Tyrosine metabolism_Homo sapiens_hsa003500.98624276
83Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.97985828
84Lysosome_Homo sapiens_hsa041420.97575366
85Caffeine metabolism_Homo sapiens_hsa002320.93842317
86Phenylalanine metabolism_Homo sapiens_hsa003600.93612567
87Nicotine addiction_Homo sapiens_hsa050330.92969286
88Glycerolipid metabolism_Homo sapiens_hsa005610.91450555
89ABC transporters_Homo sapiens_hsa020100.91226433
90Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.91196720
91Phagosome_Homo sapiens_hsa041450.90730944
92Starch and sucrose metabolism_Homo sapiens_hsa005000.89912631
93GABAergic synapse_Homo sapiens_hsa047270.89142325
94Non-small cell lung cancer_Homo sapiens_hsa052230.88517812
95Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.88421313
96Leukocyte transendothelial migration_Homo sapiens_hsa046700.88081834
97Carbohydrate digestion and absorption_Homo sapiens_hsa049730.87390907
98Cysteine and methionine metabolism_Homo sapiens_hsa002700.87272473
99African trypanosomiasis_Homo sapiens_hsa051430.86018871
100Shigellosis_Homo sapiens_hsa051310.84102249
101Carbon metabolism_Homo sapiens_hsa012000.84000901
102Biosynthesis of amino acids_Homo sapiens_hsa012300.82275768
103Apoptosis_Homo sapiens_hsa042100.81860013
104Fat digestion and absorption_Homo sapiens_hsa049750.81049888
105Folate biosynthesis_Homo sapiens_hsa007900.79504457
106Renin-angiotensin system_Homo sapiens_hsa046140.77803100
107Ether lipid metabolism_Homo sapiens_hsa005650.77789005
108Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.77073793
109Glutamatergic synapse_Homo sapiens_hsa047240.74345091
110Drug metabolism - other enzymes_Homo sapiens_hsa009830.71686497
111Staphylococcus aureus infection_Homo sapiens_hsa051500.69659092
112SNARE interactions in vesicular transport_Homo sapiens_hsa041300.68797071
113Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.66171184
114Salmonella infection_Homo sapiens_hsa051320.65103623
115Galactose metabolism_Homo sapiens_hsa000520.62893172
116Pancreatic cancer_Homo sapiens_hsa052120.62092475
117Glycerophospholipid metabolism_Homo sapiens_hsa005640.60877050
118Cyanoamino acid metabolism_Homo sapiens_hsa004600.60688604
119Glutathione metabolism_Homo sapiens_hsa004800.60660912
120Epstein-Barr virus infection_Homo sapiens_hsa051690.59731065
121Platelet activation_Homo sapiens_hsa046110.58722938
122Viral carcinogenesis_Homo sapiens_hsa052030.57324152
123alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.53936217
124Prolactin signaling pathway_Homo sapiens_hsa049170.53667595
125Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.52705463
126Metabolic pathways_Homo sapiens_hsa011000.52152360
127Sulfur relay system_Homo sapiens_hsa041220.52105063
128Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.51703829
129Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.51045086
130Mineral absorption_Homo sapiens_hsa049780.49467127
131Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.48965181
132Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.48707817
133Maturity onset diabetes of the young_Homo sapiens_hsa049500.48240178
134Salivary secretion_Homo sapiens_hsa049700.48086595
135Chronic myeloid leukemia_Homo sapiens_hsa052200.44696366
136Selenocompound metabolism_Homo sapiens_hsa004500.44488170
137Insulin resistance_Homo sapiens_hsa049310.44323420
138Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.43906793
139Morphine addiction_Homo sapiens_hsa050320.41927756
140Pentose phosphate pathway_Homo sapiens_hsa000300.40481835
141Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.39263701
142Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.38689865
143FoxO signaling pathway_Homo sapiens_hsa040680.38161094
144Linoleic acid metabolism_Homo sapiens_hsa005910.37631896
145Cocaine addiction_Homo sapiens_hsa050300.37604639
146Arachidonic acid metabolism_Homo sapiens_hsa005900.37260272
147Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.36808921
148Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.33644160
149Oxidative phosphorylation_Homo sapiens_hsa001900.32829595
150Phosphatidylinositol signaling system_Homo sapiens_hsa040700.32655441
151Circadian entrainment_Homo sapiens_hsa047130.32197125
152Sphingolipid metabolism_Homo sapiens_hsa006000.31765280
153Lysine degradation_Homo sapiens_hsa003100.31303117
154Fructose and mannose metabolism_Homo sapiens_hsa000510.31023746
155Adipocytokine signaling pathway_Homo sapiens_hsa049200.30542722
156Insulin secretion_Homo sapiens_hsa049110.30019946
157Gastric acid secretion_Homo sapiens_hsa049710.29922316
158Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.27360860
159Synaptic vesicle cycle_Homo sapiens_hsa047210.27014938
160Prion diseases_Homo sapiens_hsa050200.25703562
161Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.25640251
162Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.24243557
163Ovarian steroidogenesis_Homo sapiens_hsa049130.24052341
164Serotonergic synapse_Homo sapiens_hsa047260.20062448
165Pancreatic secretion_Homo sapiens_hsa049720.19806120
166Collecting duct acid secretion_Homo sapiens_hsa049660.18930250
167Thyroid hormone synthesis_Homo sapiens_hsa049180.17207606
168Alzheimers disease_Homo sapiens_hsa050100.16832371
169Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.16107951
170Taste transduction_Homo sapiens_hsa047420.15594025

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