ABHD4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)7.67310390
2central nervous system myelination (GO:0022010)7.67310390
3astrocyte development (GO:0014002)5.49456593
4myelin maintenance (GO:0043217)5.46676881
5cellular response to cadmium ion (GO:0071276)5.44767535
6ensheathment of neurons (GO:0007272)5.43523605
7axon ensheathment (GO:0008366)5.43523605
8myelination (GO:0042552)5.41440610
9adhesion of symbiont to host (GO:0044406)5.23619170
10fatty acid elongation (GO:0030497)5.18916600
11cellular response to follicle-stimulating hormone stimulus (GO:0071372)5.04986890
12fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.75344071
13gonadal mesoderm development (GO:0007506)4.67124222
14C21-steroid hormone biosynthetic process (GO:0006700)4.62647772
15estrogen biosynthetic process (GO:0006703)4.52741339
16peripheral nervous system axon ensheathment (GO:0032292)4.52083177
17myelination in peripheral nervous system (GO:0022011)4.52083177
18COPI coating of Golgi vesicle (GO:0048205)4.49015400
19Golgi transport vesicle coating (GO:0048200)4.49015400
20virion attachment to host cell (GO:0019062)4.45293103
21adhesion of symbiont to host cell (GO:0044650)4.45293103
22NADPH regeneration (GO:0006740)4.39125924
23regulation of integrin-mediated signaling pathway (GO:2001044)4.29313391
24fusion of sperm to egg plasma membrane (GO:0007342)4.25984272
25extracellular fibril organization (GO:0043206)4.24354440
26alpha-linolenic acid metabolic process (GO:0036109)4.20734311
27pentose-phosphate shunt (GO:0006098)4.18366096
28creatine metabolic process (GO:0006600)4.09373452
29polyketide metabolic process (GO:0030638)4.07979151
30doxorubicin metabolic process (GO:0044598)4.07979151
31daunorubicin metabolic process (GO:0044597)4.07979151
32very long-chain fatty acid metabolic process (GO:0000038)4.06252595
33positive regulation of male gonad development (GO:2000020)3.86781269
34Leydig cell differentiation (GO:0033327)3.78598013
35fibril organization (GO:0097435)3.76780333
36sex determination (GO:0007530)3.74053848
37response to lead ion (GO:0010288)3.73507179
38barbed-end actin filament capping (GO:0051016)3.72559789
39response to follicle-stimulating hormone (GO:0032354)3.67424414
40glomerular basement membrane development (GO:0032836)3.64633811
41androgen biosynthetic process (GO:0006702)3.58160221
42eye photoreceptor cell differentiation (GO:0001754)3.54491753
43photoreceptor cell differentiation (GO:0046530)3.54491753
44aminoglycoside antibiotic metabolic process (GO:0030647)3.53381276
45platelet aggregation (GO:0070527)3.49953045
46cyclooxygenase pathway (GO:0019371)3.48010254
47long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.45456922
48thrombin receptor signaling pathway (GO:0070493)3.38510939
49peptidyl-tyrosine autophosphorylation (GO:0038083)3.37244688
50type B pancreatic cell proliferation (GO:0044342)3.34594041
51platelet degranulation (GO:0002576)3.33666385
52maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.32314887
53negative regulation of protein localization to cell surface (GO:2000009)3.32135856
54regulation of male gonad development (GO:2000018)3.29730166
55glucose catabolic process (GO:0006007)3.29208430
56beta-amyloid metabolic process (GO:0050435)3.26268455
57oligodendrocyte differentiation (GO:0048709)3.26152519
58amyloid precursor protein catabolic process (GO:0042987)3.24507563
59estrogen metabolic process (GO:0008210)3.24297173
60amyloid precursor protein metabolic process (GO:0042982)3.21657312
61regulation of cholesterol biosynthetic process (GO:0045540)3.21573603
62response to lipoprotein particle (GO:0055094)3.21515824
63piRNA metabolic process (GO:0034587)3.20696379
64cellular response to cholesterol (GO:0071397)3.19943465
65protein retention in ER lumen (GO:0006621)3.17226369
66fatty-acyl-CoA biosynthetic process (GO:0046949)3.15137058
67positive regulation of pseudopodium assembly (GO:0031274)3.13985779
68negative regulation of smooth muscle cell migration (GO:0014912)3.12037015
69Sertoli cell development (GO:0060009)3.11903317
70cholesterol biosynthetic process (GO:0006695)3.10880617
71blood coagulation, intrinsic pathway (GO:0007597)3.09154547
72glomerular filtration (GO:0003094)3.06086394
73pinocytosis (GO:0006907)3.05563098
74regulation of gonadotropin secretion (GO:0032276)3.02136287
75response to methylmercury (GO:0051597)3.01373892
76renal filtration (GO:0097205)3.00059449
77plasma membrane fusion (GO:0045026)2.99051197
78negative regulation of stress fiber assembly (GO:0051497)2.98275256
79cell adhesion mediated by integrin (GO:0033627)2.96755198
80stress fiber assembly (GO:0043149)2.95797802
81skin morphogenesis (GO:0043589)2.94984924
82regulation of hydrogen peroxide-induced cell death (GO:1903205)2.91621071
83regulation of platelet aggregation (GO:0090330)2.90168066
84asymmetric protein localization (GO:0008105)2.89192910
85NADP metabolic process (GO:0006739)2.87840472
86blood vessel maturation (GO:0001955)2.87312593
87pentose metabolic process (GO:0019321)2.87078244
88response to leptin (GO:0044321)2.87066573
89glutamine family amino acid biosynthetic process (GO:0009084)2.86365748
90L-serine transport (GO:0015825)2.85471713
91cellular response to growth hormone stimulus (GO:0071378)2.85302805
92progesterone metabolic process (GO:0042448)2.83706628
93long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.83176945
94membrane tubulation (GO:0097320)2.83123175
95membrane protein ectodomain proteolysis (GO:0006509)2.82829687
96regulation of cholesterol esterification (GO:0010872)2.81793372
97glial cell development (GO:0021782)2.81780906
98peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.79554590
99sterol biosynthetic process (GO:0016126)2.78390469
100cellular response to gonadotropin stimulus (GO:0071371)2.78128538
101positive regulation of oligodendrocyte differentiation (GO:0048714)2.77837921
102fatty-acyl-CoA metabolic process (GO:0035337)2.77716190
103membrane invagination (GO:0010324)2.76894744
104acyl-CoA biosynthetic process (GO:0071616)2.76565648
105thioester biosynthetic process (GO:0035384)2.76565648
106macroautophagy (GO:0016236)2.76513332
107negative regulation of homotypic cell-cell adhesion (GO:0034111)2.75663180
108L-serine metabolic process (GO:0006563)2.73988133
109retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.73978287
110negative regulation of protein localization to plasma membrane (GO:1903077)2.73745827
111phagocytosis, recognition (GO:0006910)2.73467188
112cellular response to leptin stimulus (GO:0044320)2.73251418
113apical protein localization (GO:0045176)2.72213882
114triglyceride catabolic process (GO:0019433)2.71871163
115linoleic acid metabolic process (GO:0043651)2.71368701
116tricarboxylic acid metabolic process (GO:0072350)2.70940348
117glucose 6-phosphate metabolic process (GO:0051156)2.70835572
118ovulation cycle (GO:0042698)2.70537123
119C21-steroid hormone metabolic process (GO:0008207)2.70434912
120anatomical structure regression (GO:0060033)2.70215188
121regulation of platelet activation (GO:0010543)2.69924755
122positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.68390980
123positive regulation of Rho protein signal transduction (GO:0035025)2.67729726
124glial cell proliferation (GO:0014009)2.67482076
125negative regulation of platelet activation (GO:0010544)2.66176581
126retina vasculature morphogenesis in camera-type eye (GO:0061299)2.65258894
127lens fiber cell development (GO:0070307)2.64499402
128neutral lipid catabolic process (GO:0046461)2.64124779
129acylglycerol catabolic process (GO:0046464)2.64124779
130regulation of cholesterol metabolic process (GO:0090181)2.62989876
131protein maturation by protein folding (GO:0022417)2.62184362
132positive regulation of actin filament depolymerization (GO:0030836)2.61585993
133positive regulation of hemostasis (GO:1900048)2.61139928
134positive regulation of blood coagulation (GO:0030194)2.61139928
135nephron tubule formation (GO:0072079)2.60493237
136low-density lipoprotein particle clearance (GO:0034383)2.59871305
137adenosine receptor signaling pathway (GO:0001973)2.59636292
138sex differentiation (GO:0007548)2.59480522
139positive regulation of coagulation (GO:0050820)2.59252361
140positive regulation of macrophage cytokine production (GO:0060907)2.57057321
141regulation of pseudopodium assembly (GO:0031272)2.56953360
142phagocytosis, engulfment (GO:0006911)2.56087880
143dicarboxylic acid biosynthetic process (GO:0043650)2.54330890
144negative regulation of hydrogen peroxide-induced cell death (GO:1903206)2.53694075
145positive regulation of gliogenesis (GO:0014015)2.53575996
146positive regulation of extracellular matrix organization (GO:1903055)2.52881108
147enteric nervous system development (GO:0048484)2.52298108
148negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.51488120
149hemoglobin metabolic process (GO:0020027)2.50513680
150ethanol oxidation (GO:0006069)2.49869986
151regulation of collateral sprouting (GO:0048670)2.49718748
152cholesterol metabolic process (GO:0008203)2.48479399
153peptidyl-glutamic acid carboxylation (GO:0017187)2.48261025
154protein carboxylation (GO:0018214)2.48261025
155positive regulation of astrocyte differentiation (GO:0048711)2.48219569
156response to nitrosative stress (GO:0051409)2.47831099
157positive regulation of cellular amide metabolic process (GO:0034250)2.46595042
158positive regulation of glial cell differentiation (GO:0045687)2.46580605
159serine transport (GO:0032329)2.45989480
160positive regulation of receptor recycling (GO:0001921)2.45943776
161regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.45866506
162sterol metabolic process (GO:0016125)2.45858099
163keratan sulfate catabolic process (GO:0042340)2.44693288
164peptide catabolic process (GO:0043171)2.44568492
165regulation of lipoprotein metabolic process (GO:0050746)2.44565050
166sterol catabolic process (GO:0016127)2.44248185
167cholesterol catabolic process (GO:0006707)2.44248185
168response to misfolded protein (GO:0051788)2.43801033
169negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)2.43494981
170extracellular matrix assembly (GO:0085029)2.42425482
171glucocorticoid biosynthetic process (GO:0006704)2.42275127
172triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.41469522
173lipoxygenase pathway (GO:0019372)2.40749527
174proline biosynthetic process (GO:0006561)2.40210837
175positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.39193117
176glycoside metabolic process (GO:0016137)2.37241894
177angiogenesis involved in wound healing (GO:0060055)2.37183465
178xenobiotic catabolic process (GO:0042178)2.35223587
179homotypic cell-cell adhesion (GO:0034109)2.32096311
180dermatan sulfate biosynthetic process (GO:0030208)2.31017084
181positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.30494622
182regulation of early endosome to late endosome transport (GO:2000641)2.30074139
183endothelium development (GO:0003158)2.29327577
184fibrinolysis (GO:0042730)2.28808456
185regulation of extracellular matrix disassembly (GO:0010715)2.28707544
186basement membrane organization (GO:0071711)2.28381866
187positive regulation of endothelial cell apoptotic process (GO:2000353)2.27791349

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human4.59379620
2STAT6_21828071_ChIP-Seq_BEAS2B_Human3.08176319
3TRIM28_21343339_ChIP-Seq_HEK293_Human3.03079944
4PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.99494989
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.85962036
6* TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.61401698
7RARG_19884340_ChIP-ChIP_MEFs_Mouse2.52583185
8CLOCK_20551151_ChIP-Seq_293T_Human2.48046105
9ESR2_21235772_ChIP-Seq_MCF-7_Human2.28661816
10POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.17449977
11ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.13692075
12TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.05496035
13Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.93330763
14EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.91056800
15NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.90815938
16* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.75411434
17CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.74539124
18RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.72981495
19WT1_19549856_ChIP-ChIP_CCG9911_Human1.71923976
20EP300_21415370_ChIP-Seq_HL-1_Mouse1.68519196
21NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.65286655
22NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.61423505
23EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.59787919
24LXR_22158963_ChIP-Seq_LIVER_Mouse1.57293168
25RXR_22158963_ChIP-Seq_LIVER_Mouse1.54401373
26RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.54165455
27* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.51575531
28WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.48738853
29CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.48027108
30NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.47853192
31TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.46873176
32GATA2_21666600_ChIP-Seq_HMVEC_Human1.43998105
33RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.41229634
34P63_26484246_Chip-Seq_KERATINOCYTES_Human1.41064362
35* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.40846852
36CDX2_19796622_ChIP-Seq_MESCs_Mouse1.40525064
37CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.38818040
38GATA1_26923725_Chip-Seq_HPCs_Mouse1.36567332
39* EOMES_21245162_ChIP-Seq_HESCs_Human1.36526139
40TBX20_22328084_ChIP-Seq_HEART_Mouse1.35629352
41TBX20_22080862_ChIP-Seq_HEART_Mouse1.35629352
42CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.34844605
43ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.33319109
44ELK3_25401928_ChIP-Seq_HUVEC_Human1.31956124
45ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.31616100
46NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.31253376
47* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.31220111
48* GATA1_19941827_ChIP-Seq_MEL_Mouse1.30789928
49ESR1_21235772_ChIP-Seq_MCF-7_Human1.30748048
50SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.30158861
51MYB_21317192_ChIP-Seq_ERMYB_Mouse1.29445969
52* RACK7_27058665_Chip-Seq_MCF-7_Human1.28518417
53NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.28462854
54NRF2_20460467_ChIP-Seq_MEFs_Mouse1.28462854
55PPARA_22158963_ChIP-Seq_LIVER_Mouse1.28229291
56GATA1_19941826_ChIP-Seq_K562_Human1.27185453
57TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.26869060
58STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.25874994
59* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.25675819
60PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.22871984
61TP53_22127205_ChIP-Seq_IMR90_Human1.22763545
62TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.22323410
63KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.22093964
64KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.22093964
65KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.22093964
66SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.22082190
67KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.22052074
68* FOXO3_23340844_ChIP-Seq_DLD1_Human1.21981631
69NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.21564347
70SMC3_22415368_ChIP-Seq_MEFs_Mouse1.20001893
71ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.19324383
72* ATF3_27146783_Chip-Seq_COLON_Human1.18652467
73ERG_21242973_ChIP-ChIP_JURKAT_Human1.16443541
74LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.14791935
75PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.14688651
76PPAR_26484153_Chip-Seq_NCI-H1993_Human1.14602866
77SMC1_22415368_ChIP-Seq_MEFs_Mouse1.14388603
78SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.12745198
79STAT3_1855785_ChIP-Seq_MESCs_Mouse1.11298612
80LXR_22292898_ChIP-Seq_THP-1_Human1.10855342
81ESR1_20079471_ChIP-ChIP_T-47D_Human1.10695322
82TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.09666428
83MTF2_20144788_ChIP-Seq_MESCs_Mouse1.09483437
84TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.09310114
85ZFP281_18757296_ChIP-ChIP_E14_Mouse1.09089113
86TP53_23651856_ChIP-Seq_MEFs_Mouse1.08980969
87* CTCF_20526341_ChIP-Seq_ESCs_Human1.08692230
88P300_27058665_Chip-Seq_ZR-75-30cells_Human1.08467831
89* CJUN_26792858_Chip-Seq_BT549_Human1.07767009
90SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.07316242
91THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.04058571
92TCF3_18692474_ChIP-Seq_MEFs_Mouse1.04023842
93SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.03971837
94* TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse1.02456696
95SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.02376115
96SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.02376115
97PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.02106098
98NFIB_24661679_ChIP-Seq_LUNG_Mouse1.01899245
99SOX9_24532713_ChIP-Seq_HFSC_Mouse1.01828724
100LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.01745730
101MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.01669735
102SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01321318
103FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.99768135
104WT1_25993318_ChIP-Seq_PODOCYTE_Human0.98838832
105TFEB_21752829_ChIP-Seq_HELA_Human0.96609755
106TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96595148
107OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.95892362
108CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95667613
109NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.95533297
110KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.95379363
111NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.95040149
112KLF4_18555785_ChIP-Seq_MESCs_Mouse0.94571311
113GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.93629391
114SPI1_23127762_ChIP-Seq_K562_Human0.93587035
115KDM2B_26808549_Chip-Seq_SUP-B15_Human0.93523904
116STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.92771041
117UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.92292872
118RUNX1_22412390_ChIP-Seq_EML_Mouse0.92254685
119ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.92151745
120SA1_22415368_ChIP-Seq_MEFs_Mouse0.91371108
121SOX2_20726797_ChIP-Seq_SW620_Human0.91186727
122TP63_22573176_ChIP-Seq_HFKS_Human0.91014489
123BCOR_27268052_Chip-Seq_Bcells_Human0.90942079
124RAD21_21589869_ChIP-Seq_MESCs_Mouse0.90738759
125MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.90544386
126PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.89680883
127NCOR1_26117541_ChIP-Seq_K562_Human0.89374802
128SRY_22984422_ChIP-ChIP_TESTIS_Rat0.89216008
129JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.88567768
130HIF1A_21447827_ChIP-Seq_MCF-7_Human0.87890029
131FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.87851716
132* TP53_20018659_ChIP-ChIP_R1E_Mouse0.87385570
133FOXA2_19822575_ChIP-Seq_HepG2_Human0.86854533
134KDM2B_26808549_Chip-Seq_K562_Human0.86830650
135* CSB_26484114_Chip-Seq_FIBROBLAST_Human0.86210266
136GATA2_19941826_ChIP-Seq_K562_Human0.84355479
137* EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.83630181
138ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.83013629
139JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.81674111
140SA1_27219007_Chip-Seq_ERYTHROID_Human0.81044558
141SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.80947041
142ZNF263_19887448_ChIP-Seq_K562_Human0.80082371
143NANOG_18692474_ChIP-Seq_MEFs_Mouse0.79763903
144IKZF1_21737484_ChIP-ChIP_HCT116_Human0.79676885
145SMC4_20622854_ChIP-Seq_HELA_Human0.79258127
146KLF5_25053715_ChIP-Seq_YYC3_Human0.78395817
147KDM2B_26808549_Chip-Seq_DND41_Human0.78295539
148RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.77061285

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.23628984
2MP0000920_abnormal_myelination3.96152534
3MP0003566_abnormal_cell_adhesion3.70091090
4MP0005464_abnormal_platelet_physiology3.68006064
5MP0005410_abnormal_fertilization3.51285410
6MP0008004_abnormal_stomach_pH3.35346699
7MP0003690_abnormal_glial_cell3.32492225
8MP0003329_amyloid_beta_deposits3.23184786
9MP0003950_abnormal_plasma_membrane3.07417654
10MP0003878_abnormal_ear_physiology2.71780882
11MP0005377_hearing/vestibular/ear_phenot2.71780882
12MP0009840_abnormal_foam_cell2.68540720
13MP0004272_abnormal_basement_membrane2.65504999
14MP0005623_abnormal_meninges_morphology2.62828131
15MP0003634_abnormal_glial_cell2.46046761
16MP0009384_cardiac_valve_regurgitation2.35398086
17MP0004885_abnormal_endolymph2.25575665
18MP0005257_abnormal_intraocular_pressure2.23170859
19MP0001958_emphysema2.11515131
20MP0002295_abnormal_pulmonary_circulatio2.05853677
21MP0005058_abnormal_lysosome_morphology2.02782085
22MP0000604_amyloidosis2.00986230
23MP0002653_abnormal_ependyma_morphology2.00529946
24MP0000465_gastrointestinal_hemorrhage1.85121863
25MP0003806_abnormal_nucleotide_metabolis1.83571768
26MP0008995_early_reproductive_senescence1.82680641
27MP0003941_abnormal_skin_development1.82165544
28MP0003279_aneurysm1.78054081
29MP0003011_delayed_dark_adaptation1.76501443
30MP0003195_calcinosis1.74906575
31MP0000639_abnormal_adrenal_gland1.68877059
32MP0003632_abnormal_nervous_system1.66313299
33MP0004858_abnormal_nervous_system1.65855963
34MP0005503_abnormal_tendon_morphology1.60088455
35MP0004036_abnormal_muscle_relaxation1.57427149
36MP0005647_abnormal_sex_gland1.51494948
37MP0003186_abnormal_redox_activity1.47554086
38MP0005275_abnormal_skin_tensile1.46544075
39MP0001661_extended_life_span1.42602788
40MP0003172_abnormal_lysosome_physiology1.40035269
41MP0005365_abnormal_bile_salt1.39701635
42MP0002254_reproductive_system_inflammat1.36481790
43MP0005083_abnormal_biliary_tract1.32498495
44MP0002132_abnormal_respiratory_system1.32224971
45MP0000858_altered_metastatic_potential1.30138386
46MP0003303_peritoneal_inflammation1.28825316
47MP0005670_abnormal_white_adipose1.27317791
48MP0006054_spinal_hemorrhage1.26727161
49MP0000767_abnormal_smooth_muscle1.25775823
50MP0004084_abnormal_cardiac_muscle1.23929248
51MP0009278_abnormal_bone_marrow1.22875793
52MP0003828_pulmonary_edema1.20713363
53MP0001542_abnormal_bone_strength1.20294117
54MP0006138_congestive_heart_failure1.20262035
55MP0000343_altered_response_to1.19252095
56MP0003724_increased_susceptibility_to1.18162857
57MP0004134_abnormal_chest_morphology1.17983365
58MP0003656_abnormal_erythrocyte_physiolo1.17919206
59MP0004233_abnormal_muscle_weight1.17789648
60MP0000751_myopathy1.17374108
61MP0004147_increased_porphyrin_level1.16989848
62MP0005595_abnormal_vascular_smooth1.15900153
63MP0010030_abnormal_orbit_morphology1.14670751
64MP0005171_absent_coat_pigmentation1.12355837
65MP0001485_abnormal_pinna_reflex1.11410129
66MP0003436_decreased_susceptibility_to1.10918371
67MP0001929_abnormal_gametogenesis1.10703256
68MP0003075_altered_response_to1.10435404
69MP0003698_abnormal_male_reproductive1.08133640
70MP0003942_abnormal_urinary_system1.07403903
71MP0000749_muscle_degeneration1.06951798
72MP0000747_muscle_weakness1.06203664
73MP0001533_abnormal_skeleton_physiology1.03820409
74MP0010678_abnormal_skin_adnexa1.03162185
75MP0003300_gastrointestinal_ulcer1.02688014
76MP0003191_abnormal_cellular_cholesterol1.01735233
77MP0002168_other_aberrant_phenotype1.01619588
78MP0003091_abnormal_cell_migration1.01282871
79MP0002090_abnormal_vision1.00654920
80MP0000383_abnormal_hair_follicle0.98288057
81MP0004130_abnormal_muscle_cell0.97945731
82MP0005508_abnormal_skeleton_morphology0.97289878
83MP0005451_abnormal_body_composition0.95527426
84MP0000647_abnormal_sebaceous_gland0.95283290
85MP0005167_abnormal_blood-brain_barrier0.95226058
86MP0010329_abnormal_lipoprotein_level0.93513033
87MP0002139_abnormal_hepatobiliary_system0.93002227
88MP0005165_increased_susceptibility_to0.92664279
89MP0004087_abnormal_muscle_fiber0.89887485
90MP0000462_abnormal_digestive_system0.89759980
91MP0001851_eye_inflammation0.89515570
92MP0005390_skeleton_phenotype0.89419136
93MP0000249_abnormal_blood_vessel0.89058420
94MP0002210_abnormal_sex_determination0.88389952
95MP0005248_abnormal_Harderian_gland0.87486216
96MP0005666_abnormal_adipose_tissue0.87419095
97MP0001145_abnormal_male_reproductive0.87369254
98MP0005367_renal/urinary_system_phenotyp0.87021514
99MP0000516_abnormal_urinary_system0.87021514
100MP0003631_nervous_system_phenotype0.86912175
101MP0003045_fibrosis0.86421466
102MP0005319_abnormal_enzyme/_coenzyme0.86411143
103MP0000534_abnormal_ureter_morphology0.83576388
104MP0003448_altered_tumor_morphology0.83311765
105MP0003221_abnormal_cardiomyocyte_apopto0.83191179
106MP0001915_intracranial_hemorrhage0.82302758
107MP0005584_abnormal_enzyme/coenzyme_acti0.81944348
108MP0005332_abnormal_amino_acid0.80643509
109MP0005397_hematopoietic_system_phenotyp0.79782035
110MP0001545_abnormal_hematopoietic_system0.79782035
111MP0004019_abnormal_vitamin_homeostasis0.79216337
112MP0003115_abnormal_respiratory_system0.79032362
113MP0005164_abnormal_response_to0.78656474
114MP0003705_abnormal_hypodermis_morpholog0.78473878
115MP0005621_abnormal_cell_physiology0.78262730
116MP0005084_abnormal_gallbladder_morpholo0.77404733
117MP0004742_abnormal_vestibular_system0.76924300
118MP0000428_abnormal_craniofacial_morphol0.76654827
119MP0000733_abnormal_muscle_development0.76272117
120MP0000653_abnormal_sex_gland0.76225544
121MP0002972_abnormal_cardiac_muscle0.76164597
122MP0005501_abnormal_skin_physiology0.75713199
123MP0009763_increased_sensitivity_to0.75640045
124MP0001243_abnormal_dermal_layer0.74217497
125MP0001727_abnormal_embryo_implantation0.74069499
126MP0002249_abnormal_larynx_morphology0.73173637
127MP0005023_abnormal_wound_healing0.73154537
128MP0008877_abnormal_DNA_methylation0.72903240
129MP0002118_abnormal_lipid_homeostasis0.72820622
130MP0000230_abnormal_systemic_arterial0.72689080
131MP0002998_abnormal_bone_remodeling0.71843234
132MP0001849_ear_inflammation0.71684605
133MP0004883_abnormal_blood_vessel0.71590724
134MP0000467_abnormal_esophagus_morphology0.71521749
135MP0002229_neurodegeneration0.70367556
136MP0010630_abnormal_cardiac_muscle0.70365286
137MP0003795_abnormal_bone_structure0.70363740
138MP0001614_abnormal_blood_vessel0.69166200
139MP0001905_abnormal_dopamine_level0.68131281
140MP0003453_abnormal_keratinocyte_physiol0.68059063
141MP0002128_abnormal_blood_circulation0.67959657
142MP0010368_abnormal_lymphatic_system0.66326254
143MP0001175_abnormal_lung_morphology0.66209869
144MP0008260_abnormal_autophagy0.66141022
145MP0000750_abnormal_muscle_regeneration0.65968879
146MP0008789_abnormal_olfactory_epithelium0.65296418
147MP0005330_cardiomyopathy0.64889172
148MP0000598_abnormal_liver_morphology0.64215354
149MP0001544_abnormal_cardiovascular_syste0.63924256
150MP0005375_adipose_tissue_phenotype0.62915806

Predicted human phenotypes

RankGene SetZ-score
1Neurofibrillary tangles (HP:0002185)5.74572253
2Petechiae (HP:0000967)5.47212449
3Increased mean platelet volume (HP:0011877)5.06878842
4Gonadal dysgenesis (HP:0000133)5.05179412
5Purpura (HP:0000979)4.97180735
6Abnormal platelet volume (HP:0011876)4.82037152
7Menorrhagia (HP:0000132)4.78621255
8Prolonged bleeding time (HP:0003010)4.46160159
9Male infertility (HP:0003251)4.04990322
10Cerebral inclusion bodies (HP:0100314)4.01525884
11Gingival bleeding (HP:0000225)3.93446202
12Clumsiness (HP:0002312)3.58957128
13Cervical subluxation (HP:0003308)3.52390945
14Premature rupture of membranes (HP:0001788)3.50238683
15Gonadotropin excess (HP:0000837)3.49173496
16Broad metatarsal (HP:0001783)3.42483536
17Degeneration of the lateral corticospinal tracts (HP:0002314)3.42465282
18Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.42465282
19Protrusio acetabuli (HP:0003179)3.41223952
20Stridor (HP:0010307)3.36542309
21Abnormal gallbladder physiology (HP:0012438)3.26818150
22Cholecystitis (HP:0001082)3.26818150
23Mesangial abnormality (HP:0001966)3.26172349
24Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.25303953
25Epistaxis (HP:0000421)3.24116349
26Diaphragmatic weakness (HP:0009113)3.12594664
27Ankle clonus (HP:0011448)3.04715922
28Increased cerebral lipofuscin (HP:0011813)2.97665697
29Onion bulb formation (HP:0003383)2.96391945
30Vascular tortuosity (HP:0004948)2.95953335
31Premature skin wrinkling (HP:0100678)2.93030769
32Megalencephaly (HP:0001355)2.90323367
33Abnormal sex determination (HP:0012244)2.87785415
34Sex reversal (HP:0012245)2.87785415
35Abnormality of dentin (HP:0010299)2.87479453
36Synostosis involving the elbow (HP:0003938)2.87448765
37Humeroradial synostosis (HP:0003041)2.87448765
38Loss of speech (HP:0002371)2.85128954
39Increased neuronal autofluorescent lipopigment (HP:0002074)2.84134852
40Segmental peripheral demyelination/remyelination (HP:0003481)2.84051422
41Hyporeflexia of lower limbs (HP:0002600)2.82802884
42Supranuclear gaze palsy (HP:0000605)2.75538490
43Nuclear cataract (HP:0100018)2.72759744
44Axonal loss (HP:0003447)2.70701895
45Arterial tortuosity (HP:0005116)2.69600052
46Hypoplastic pelvis (HP:0008839)2.68746007
47Aortic dissection (HP:0002647)2.68335817
48Systemic lupus erythematosus (HP:0002725)2.65592392
49Ankle contracture (HP:0006466)2.63026967
50Myocardial infarction (HP:0001658)2.58378361
51Peripheral hypomyelination (HP:0007182)2.56783481
52Renal salt wasting (HP:0000127)2.56464520
53Abnormal platelet function (HP:0011869)2.53632517
54Impaired platelet aggregation (HP:0003540)2.53632517
55Abnormal auditory evoked potentials (HP:0006958)2.50263711
56Bladder diverticulum (HP:0000015)2.50196245
57Parakeratosis (HP:0001036)2.49945227
58Hepatosplenomegaly (HP:0001433)2.48584730
59Coronal craniosynostosis (HP:0004440)2.48318899
60Vacuolated lymphocytes (HP:0001922)2.48185084
61Hypoplasia of the iris (HP:0007676)2.45833277
62Hypoplasia of the uterus (HP:0000013)2.45771833
63Aplasia involving bones of the upper limbs (HP:0009823)2.44971457
64Aplasia of the phalanges of the hand (HP:0009802)2.44971457
65Aplasia involving bones of the extremities (HP:0009825)2.44971457
66Hypoplastic left heart (HP:0004383)2.38495873
67Mitral stenosis (HP:0001718)2.35088082
68Exercise-induced muscle cramps (HP:0003710)2.33194859
69Shallow orbits (HP:0000586)2.32566312
70Prolonged neonatal jaundice (HP:0006579)2.32266802
71Tetraparesis (HP:0002273)2.31166876
72Insidious onset (HP:0003587)2.28791232
73Termporal pattern (HP:0011008)2.28791232
74Hyperlipoproteinemia (HP:0010980)2.25263991
75Dysostosis multiplex (HP:0000943)2.24599288
76Pulmonary artery stenosis (HP:0004415)2.23462116
77Hypoalphalipoproteinemia (HP:0003233)2.21601770
78Abnormality of the heme biosynthetic pathway (HP:0010472)2.20210097
79Increased circulating renin level (HP:0000848)2.20045014
80Abnormality of the corticospinal tract (HP:0002492)2.19800357
81Testicular neoplasm (HP:0010788)2.18814582
82Distal upper limb amyotrophy (HP:0007149)2.18365777
83Upper limb amyotrophy (HP:0009129)2.18365777
84Hyperglycinemia (HP:0002154)2.12687679
85Dilatation of the ascending aorta (HP:0005111)2.12385420
86Gowers sign (HP:0003391)2.12212771
87Abnormality of glycolipid metabolism (HP:0010969)2.11816914
88Abnormality of liposaccharide metabolism (HP:0010968)2.11816914
89Abnormality of glycosphingolipid metabolism (HP:0004343)2.11816914
90Joint hemorrhage (HP:0005261)2.11548125
91Intrahepatic cholestasis (HP:0001406)2.11299955
92Difficulty running (HP:0009046)2.10932102
93Amyloidosis (HP:0011034)2.09714687
94Abnormality of the common coagulation pathway (HP:0010990)2.09044403
95Abnormality of glycine metabolism (HP:0010895)2.08929415
96Abnormality of serine family amino acid metabolism (HP:0010894)2.08929415
97Abnormality of macrophages (HP:0004311)2.07390819
98Abnormality of skeletal muscle fiber size (HP:0012084)2.06197142
99Spinal rigidity (HP:0003306)2.05593672
100Muscle fiber splitting (HP:0003555)2.04673999
101Urinary glycosaminoglycan excretion (HP:0003541)2.04429579
102Mucopolysacchariduria (HP:0008155)2.04429579
103Blue sclerae (HP:0000592)2.03570631
104Wormian bones (HP:0002645)2.02359163
105Bell-shaped thorax (HP:0001591)2.01692000
106Infantile muscular hypotonia (HP:0008947)2.01658189
107Abnormality of polysaccharide metabolism (HP:0011012)2.00157239
108Abnormality of glycosaminoglycan metabolism (HP:0004371)2.00157239
109Abnormality of mucopolysaccharide metabolism (HP:0011020)2.00157239
110Hypoglycemic seizures (HP:0002173)1.97839813
111Abnormal delivery (HP:0001787)1.97074553
112Abnormality of the anterior horn cell (HP:0006802)1.95935666
113Degeneration of anterior horn cells (HP:0002398)1.95935666
114Sensory axonal neuropathy (HP:0003390)1.95664301
115Male pseudohermaphroditism (HP:0000037)1.94710903
116Retinal dysplasia (HP:0007973)1.94612554
117Episodic fever (HP:0001954)1.94428209
118Peripheral demyelination (HP:0011096)1.92808706
119Soft skin (HP:0000977)1.90664894
120Bruising susceptibility (HP:0000978)1.89052671
121Cholelithiasis (HP:0001081)1.88898926
122Bronchomalacia (HP:0002780)1.87569353
123Polycythemia (HP:0001901)1.86489626
124Pterygium (HP:0001059)1.86139001
125Aortic aneurysm (HP:0004942)1.86121240
126Intention tremor (HP:0002080)1.85909903
127Turricephaly (HP:0000262)1.85378275
128Abnormality of fatty-acid metabolism (HP:0004359)1.85345334
129Infertility (HP:0000789)1.84476840
130Clonus (HP:0002169)1.80316296
131Arachnodactyly (HP:0001166)1.79478351
132Increased variability in muscle fiber diameter (HP:0003557)1.78812951
133Cerebral hemorrhage (HP:0001342)1.78193162
134Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.77619424
135Peritonitis (HP:0002586)1.77007734
136Neonatal short-limb short stature (HP:0008921)1.76768003
137Hemorrhage of the eye (HP:0011885)1.76652700
138Follicular hyperkeratosis (HP:0007502)1.76410113
139Abolished electroretinogram (ERG) (HP:0000550)1.76364050
140Large for gestational age (HP:0001520)1.75594807
141Abnormal gallbladder morphology (HP:0012437)1.74688758
142Hypercholesterolemia (HP:0003124)1.74503937
143Spastic paraparesis (HP:0002313)1.73510315
144Back pain (HP:0003418)1.73447791
145Generalized amyotrophy (HP:0003700)1.73181897
146Vertebral hypoplasia (HP:0008417)1.72493272
147Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.72493272
148Vertebral compression fractures (HP:0002953)1.70458658
149Biconcave vertebral bodies (HP:0004586)1.70215645
150Osteolytic defects of the phalanges of the hand (HP:0009771)1.69585436
151Osteolytic defects of the hand bones (HP:0009699)1.69585436
152Venous insufficiency (HP:0005293)1.67904895
153Aneurysm (HP:0002617)1.66989999
154Xanthomatosis (HP:0000991)1.65907440
155Spastic gait (HP:0002064)1.64789458
156Hypoplasia of the odontoid process (HP:0003311)1.64309446
157Esophageal atresia (HP:0002032)1.64046638
158Femoral bowing (HP:0002980)1.63974091
159Aplasia/hypoplasia of the uterus (HP:0008684)1.63594166
160Hypoplastic heart (HP:0001961)1.63571577
161Hyperextensible skin (HP:0000974)1.63310094
162Hand muscle atrophy (HP:0009130)1.63251453
163Partial duplication of thumb phalanx (HP:0009944)1.63250490
164Deep venous thrombosis (HP:0002625)1.62999464
165Abnormality of the acetabulum (HP:0003170)1.62735560
166Ovoid vertebral bodies (HP:0003300)1.62617488
167Exercise-induced myalgia (HP:0003738)1.62586854
168Alacrima (HP:0000522)1.62272841
169Calcaneovalgus deformity (HP:0001848)1.61880881
170Neuronal loss in central nervous system (HP:0002529)1.61826432
171Hydroxyprolinuria (HP:0003080)1.61072885
172Abnormality of proline metabolism (HP:0010907)1.61072885
173Hypophosphatemic rickets (HP:0004912)1.58971997
174Atrophic scars (HP:0001075)1.58635828

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK394.10828708
2EPHB14.03706571
3NEK92.91391949
4MAPKAPK52.79489399
5ICK2.77081836
6TRIB32.68166984
7LIMK12.56173691
8PRKD32.51479393
9MET2.39959550
10TYRO32.24656659
11LMTK22.14464381
12WNK42.11984334
13OXSR12.06595273
14MAP3K31.97052890
15TESK11.92329600
16EPHA21.88929734
17EIF2AK11.86764475
18PDK31.72533136
19PDK41.72533136
20TAOK21.64638516
21SIK11.55964600
22FGFR41.55611831
23ROCK21.55104011
24TESK21.53954790
25MAP2K31.52131739
26NTRK11.51967891
27PDK21.43507089
28FGFR21.40661035
29TRPM71.40080022
30BCKDK1.38815798
31MUSK1.36592021
32PAK61.36066977
33WNK11.34408343
34STK381.32115335
35MYLK1.31280455
36LRRK21.30498896
37ILK1.28572710
38EEF2K1.26932183
39PRKG21.26142969
40KSR21.25114987
41TAOK11.23902558
42PHKG11.23772128
43PHKG21.23772128
44PKN11.22894033
45ARAF1.22585009
46PAK31.21896402
47PIM21.21407480
48ERN11.20462421
49CSNK1A1L1.20339502
50BMX1.19901676
51SIK31.19281063
52PBK1.18079136
53RIPK11.17202478
54VRK21.15880616
55MAP3K11.13463138
56DDR21.13435287
57CDK191.13281497
58PAK21.12799579
59PTK2B1.12282765
60TBK11.09785028
61MATK1.09686494
62ZAP701.09659199
63ABL21.08609404
64DMPK1.07404809
65MAP2K21.07362610
66PTK21.07198897
67MAP3K51.03273839
68PTK61.00711530
69MAP3K110.99828235
70PAK40.96079852
71MAP4K20.95628432
72CSNK1G30.94990059
73SGK4940.94263575
74SGK2230.94263575
75KIT0.91599307
76PRKD10.90229100
77PRPF4B0.87569344
78IRAK30.86975270
79MOS0.85995120
80PDGFRA0.83748634
81FLT30.82663690
82DAPK30.82612731
83BCR0.82568196
84DYRK1B0.79621333
85DYRK30.79534783
86EPHA30.78615774
87MAPK150.78412561
88PAK10.77945361
89ROCK10.76356610
90EIF2AK30.73107808
91ERBB40.72574900
92KDR0.68898196
93NEK60.63814365
94CAMK2D0.62777545
95CSNK1G10.62540175
96SMG10.61696992
97DYRK20.60861274
98CSF1R0.59062073
99IRAK10.58921313
100TTN0.57799144
101LATS10.57203634
102YES10.56071127
103EPHB20.55370850
104CAMK2G0.55093593
105TNK20.53910494
106CDC42BPA0.53637329
107RPS6KA20.53588073
108CDK90.52796834
109TYK20.51217670
110TIE10.50379044
111MAP3K120.49813469
112RAF10.49785991
113HIPK20.49737794
114MAPKAPK30.49046764
115PDGFRB0.48689875
116FER0.48377116
117CDK80.48159236
118CSNK1G20.47536021
119PINK10.46985778
120RET0.46038434
121NME20.45376063
122TGFBR20.44650998
123CAMK1D0.44126506
124MAPKAPK20.43886139
125GSK3A0.43626800
126MTOR0.42114691
127MAPK70.41737586
128SRC0.41315151
129SGK30.41041140
130PKN20.40839503
131PRKACB0.40816664
132SCYL20.40808772
133MST40.40660197
134MARK20.39911871
135HCK0.39778006
136CDK140.39322092
137MAP3K80.38588302
138LATS20.38315789
139CDK70.38250826
140PRKD20.37638045
141TNIK0.37285977
142PLK20.37136976
143FGR0.36616083
144ERBB20.36544783
145GRK60.35879431
146FES0.35807140
147STK30.34439881
148UHMK10.32845240
149MAP2K10.31869173

Predicted pathways (KEGG)

RankGene SetZ-score
1Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010404.28626892
2Fatty acid elongation_Homo sapiens_hsa000624.18311843
3Nitrogen metabolism_Homo sapiens_hsa009103.36537913
4Steroid biosynthesis_Homo sapiens_hsa001003.29549216
5Fatty acid metabolism_Homo sapiens_hsa012123.19877808
6Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.84765442
7Fatty acid biosynthesis_Homo sapiens_hsa000612.58412350
8Fatty acid degradation_Homo sapiens_hsa000712.46275450
9Propanoate metabolism_Homo sapiens_hsa006402.21745062
10Galactose metabolism_Homo sapiens_hsa000522.20835305
11Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.15053991
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.09297171
13PPAR signaling pathway_Homo sapiens_hsa033202.07744662
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.05430353
15Ether lipid metabolism_Homo sapiens_hsa005651.94686872
16alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.81737293
17Vitamin B6 metabolism_Homo sapiens_hsa007501.79927994
18Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.79121249
19Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.79031328
20ECM-receptor interaction_Homo sapiens_hsa045121.76190922
21Fructose and mannose metabolism_Homo sapiens_hsa000511.70051058
22Ovarian steroidogenesis_Homo sapiens_hsa049131.69647551
23Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.65639451
24Steroid hormone biosynthesis_Homo sapiens_hsa001401.55636199
25Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.51892462
26Glutathione metabolism_Homo sapiens_hsa004801.51858768
27Histidine metabolism_Homo sapiens_hsa003401.48352054
28Pyruvate metabolism_Homo sapiens_hsa006201.45138373
29Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.39281439
30Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.38607699
31Vitamin digestion and absorption_Homo sapiens_hsa049771.28666051
32Linoleic acid metabolism_Homo sapiens_hsa005911.27441515
33Lysosome_Homo sapiens_hsa041421.26773763
34Hedgehog signaling pathway_Homo sapiens_hsa043401.24232766
35Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.22405886
36Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.21039410
37Butanoate metabolism_Homo sapiens_hsa006501.18009383
38Sulfur metabolism_Homo sapiens_hsa009201.17635491
39Sphingolipid metabolism_Homo sapiens_hsa006001.13579858
40Platelet activation_Homo sapiens_hsa046111.11331127
41Chemical carcinogenesis_Homo sapiens_hsa052041.09413534
42Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.08511770
43Arginine and proline metabolism_Homo sapiens_hsa003301.07900881
44Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.06697073
45Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.04907897
46Mineral absorption_Homo sapiens_hsa049781.00852844
47Vibrio cholerae infection_Homo sapiens_hsa051100.98692151
48Focal adhesion_Homo sapiens_hsa045100.97121279
49Proteasome_Homo sapiens_hsa030500.96799487
50Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.96765804
51Starch and sucrose metabolism_Homo sapiens_hsa005000.94535286
52Basal cell carcinoma_Homo sapiens_hsa052170.93926419
53Tight junction_Homo sapiens_hsa045300.93203867
54Central carbon metabolism in cancer_Homo sapiens_hsa052300.91257677
55Peroxisome_Homo sapiens_hsa041460.90615265
56Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.87745293
57Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.87671246
58Amoebiasis_Homo sapiens_hsa051460.84612911
59Notch signaling pathway_Homo sapiens_hsa043300.83201467
60Arachidonic acid metabolism_Homo sapiens_hsa005900.81810471
61N-Glycan biosynthesis_Homo sapiens_hsa005100.79029795
62Arginine biosynthesis_Homo sapiens_hsa002200.78458357
63Malaria_Homo sapiens_hsa051440.76753328
64beta-Alanine metabolism_Homo sapiens_hsa004100.74499046
65Carbon metabolism_Homo sapiens_hsa012000.74289314
66Axon guidance_Homo sapiens_hsa043600.72863795
67Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.72047649
68Adipocytokine signaling pathway_Homo sapiens_hsa049200.71587696
69Glycerolipid metabolism_Homo sapiens_hsa005610.70486856
70Complement and coagulation cascades_Homo sapiens_hsa046100.68890498
71Hippo signaling pathway_Homo sapiens_hsa043900.68610504
72Protein digestion and absorption_Homo sapiens_hsa049740.64992008
73Shigellosis_Homo sapiens_hsa051310.64862234
74Phenylalanine metabolism_Homo sapiens_hsa003600.64544828
75Bile secretion_Homo sapiens_hsa049760.64399586
76Endocytosis_Homo sapiens_hsa041440.64334021
77Sphingolipid signaling pathway_Homo sapiens_hsa040710.63201832
78Adherens junction_Homo sapiens_hsa045200.62823022
79Drug metabolism - other enzymes_Homo sapiens_hsa009830.60691311
80Other glycan degradation_Homo sapiens_hsa005110.60385173
81Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.59939940
82Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.59543306
83TGF-beta signaling pathway_Homo sapiens_hsa043500.58753087
84Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.58266846
85Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.57459413
86Proteoglycans in cancer_Homo sapiens_hsa052050.56846943
87Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.56250071
88Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.55151952
89Protein export_Homo sapiens_hsa030600.54740744
90Small cell lung cancer_Homo sapiens_hsa052220.54718609
91Fat digestion and absorption_Homo sapiens_hsa049750.54176991
92Bladder cancer_Homo sapiens_hsa052190.54117675
93Primary bile acid biosynthesis_Homo sapiens_hsa001200.53788694
94Glycerophospholipid metabolism_Homo sapiens_hsa005640.53740886
95Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.53343802
96Retinol metabolism_Homo sapiens_hsa008300.53317151
97Phospholipase D signaling pathway_Homo sapiens_hsa040720.51334545
98Legionellosis_Homo sapiens_hsa051340.49981720
99Renal cell carcinoma_Homo sapiens_hsa052110.49627622
100Leukocyte transendothelial migration_Homo sapiens_hsa046700.49043722
101Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.48626548
102Biosynthesis of amino acids_Homo sapiens_hsa012300.48417445
103Pentose phosphate pathway_Homo sapiens_hsa000300.46975001
104Tryptophan metabolism_Homo sapiens_hsa003800.46649611
105Phagosome_Homo sapiens_hsa041450.46159827
106PI3K-Akt signaling pathway_Homo sapiens_hsa041510.44751243
107Glycosaminoglycan degradation_Homo sapiens_hsa005310.44414700
108SNARE interactions in vesicular transport_Homo sapiens_hsa041300.44309621
109Folate biosynthesis_Homo sapiens_hsa007900.43612474
110Regulation of actin cytoskeleton_Homo sapiens_hsa048100.41989974
111Chronic myeloid leukemia_Homo sapiens_hsa052200.40145748
112Dorso-ventral axis formation_Homo sapiens_hsa043200.39430692
1132-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.37162037
114Staphylococcus aureus infection_Homo sapiens_hsa051500.37142410
115Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.36536022
116Collecting duct acid secretion_Homo sapiens_hsa049660.35287639
117Dilated cardiomyopathy_Homo sapiens_hsa054140.35036219
118Renin-angiotensin system_Homo sapiens_hsa046140.34236277
119Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.33593248
120Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.32454092
121Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.31314595
122Cyanoamino acid metabolism_Homo sapiens_hsa004600.31257594
123Pathways in cancer_Homo sapiens_hsa052000.30833194
124Vascular smooth muscle contraction_Homo sapiens_hsa042700.30786033
125Pertussis_Homo sapiens_hsa051330.30601556
126Salmonella infection_Homo sapiens_hsa051320.30562642
127Pentose and glucuronate interconversions_Homo sapiens_hsa000400.29819782
128Prion diseases_Homo sapiens_hsa050200.29502189
129Metabolic pathways_Homo sapiens_hsa011000.28444108
130Caffeine metabolism_Homo sapiens_hsa002320.27783174
131Tyrosine metabolism_Homo sapiens_hsa003500.27656529
132Toxoplasmosis_Homo sapiens_hsa051450.26560179
133Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.26094923
134Ras signaling pathway_Homo sapiens_hsa040140.25546485
135Cysteine and methionine metabolism_Homo sapiens_hsa002700.25397405

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