ABHD5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to a large family of proteins defined by an alpha/beta hydrolase fold, and contains three sequence motifs that correspond to a catalytic triad found in the esterase/lipase/thioesterase subfamily. It differs from other members of this subfamily in that its putative catalytic triad contains an asparagine instead of the serine residue. Mutations in this gene have been associated with Chanarin-Dorfman syndrome, a triglyceride storage disease with impaired long-chain fatty acid oxidation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neutrophil activation involved in immune response (GO:0002283)5.80181324
2low-density lipoprotein particle clearance (GO:0034383)5.62850018
3detection of molecule of bacterial origin (GO:0032490)5.20649974
4positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.91623363
5positive regulation by organism of defense response of other organism involved in symbiotic interact4.87097771
6modulation by symbiont of host immune response (GO:0052553)4.87097771
7positive regulation by symbiont of host defense response (GO:0052509)4.87097771
8modulation by symbiont of host defense response (GO:0052031)4.87097771
9modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.87097771
10modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.87097771
11* regulation of sequestering of triglyceride (GO:0010889)4.76922667
12cellular extravasation (GO:0045123)4.66334456
13long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)4.52739393
14fatty-acyl-CoA biosynthetic process (GO:0046949)4.48870735
15detection of other organism (GO:0098543)4.48739421
16response to peptidoglycan (GO:0032494)4.34256047
17detection of external biotic stimulus (GO:0098581)4.32600760
18long-chain fatty-acyl-CoA metabolic process (GO:0035336)4.25004297
19neutrophil activation (GO:0042119)4.20806224
20macrophage activation involved in immune response (GO:0002281)4.18524668
21fatty-acyl-CoA metabolic process (GO:0035337)4.14582406
22thioester biosynthetic process (GO:0035384)4.12767833
23acyl-CoA biosynthetic process (GO:0071616)4.12767833
24neutrophil mediated immunity (GO:0002446)4.10910184
25regulation of interferon-beta biosynthetic process (GO:0045357)4.00611530
26granulocyte activation (GO:0036230)3.96526259
27fatty acid elongation (GO:0030497)3.95834777
28regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.87530174
29positive regulation of gamma-delta T cell activation (GO:0046645)3.85211421
30antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.83344757
31detection of bacterium (GO:0016045)3.82350326
32alpha-linolenic acid metabolic process (GO:0036109)3.77988745
33iron ion import (GO:0097286)3.74132469
34triglyceride biosynthetic process (GO:0019432)3.74109070
35regulation of mast cell degranulation (GO:0043304)3.71064353
36positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.69190034
37fatty acid transmembrane transport (GO:1902001)3.68101724
38positive regulation of mast cell activation (GO:0033005)3.66614717
39macrophage activation (GO:0042116)3.65048008
40acylglycerol biosynthetic process (GO:0046463)3.64929570
41neutral lipid biosynthetic process (GO:0046460)3.64929570
42microglial cell activation (GO:0001774)3.58893780
43plasma lipoprotein particle clearance (GO:0034381)3.58855549
44detection of biotic stimulus (GO:0009595)3.58236973
45biotin metabolic process (GO:0006768)3.56507485
46negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.56449306
47negative regulation of cell killing (GO:0031342)3.56449306
48regulation of mast cell activation involved in immune response (GO:0033006)3.56424395
49keratinization (GO:0031424)3.48130655
50production of molecular mediator involved in inflammatory response (GO:0002532)3.41528666
51linoleic acid metabolic process (GO:0043651)3.41277244
52myeloid cell activation involved in immune response (GO:0002275)3.40383108
53brown fat cell differentiation (GO:0050873)3.37723111
54positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.36396117
55positive regulation of cellular amide metabolic process (GO:0034250)3.35145476
56acetyl-CoA metabolic process (GO:0006084)3.34106648
57positive regulation of mast cell degranulation (GO:0043306)3.32568434
58positive regulation of mast cell activation involved in immune response (GO:0033008)3.32568434
59regulation of mast cell activation (GO:0033003)3.30732325
60respiratory burst (GO:0045730)3.30628576
61carnitine shuttle (GO:0006853)3.30406609
62negative regulation of glycoprotein biosynthetic process (GO:0010561)3.29643718
63fatty acid beta-oxidation (GO:0006635)3.29033364
64leukocyte migration involved in inflammatory response (GO:0002523)3.28987545
65response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.27935153
66response to host immune response (GO:0052572)3.27935153
67antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.24433600
68carnitine transmembrane transport (GO:1902603)3.24277676
69regulation of cholesterol storage (GO:0010885)3.24145217
70oxygen transport (GO:0015671)3.24141544
71leukocyte degranulation (GO:0043299)3.23460235
72negative regulation of interleukin-12 production (GO:0032695)3.20080679
73protoporphyrinogen IX metabolic process (GO:0046501)3.18683939
74carnitine transport (GO:0015879)3.17006421
75amino-acid betaine transport (GO:0015838)3.17006421
76myeloid leukocyte mediated immunity (GO:0002444)3.07503218
77lipoxygenase pathway (GO:0019372)3.06324721
78response to host (GO:0075136)3.04545945
79response to host defenses (GO:0052200)3.04545945
80response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.04545945
81thioester metabolic process (GO:0035383)3.03792465
82acyl-CoA metabolic process (GO:0006637)3.03792465
83lipopolysaccharide-mediated signaling pathway (GO:0031663)3.02971059
84positive regulation of fatty acid beta-oxidation (GO:0032000)3.02612996
85positive regulation of leukocyte degranulation (GO:0043302)3.02480568
86fatty acid oxidation (GO:0019395)3.02277480
87fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.00754724
88regulation of leukocyte degranulation (GO:0043300)3.00466911
89regulation of lipoprotein metabolic process (GO:0050746)2.97998708
90lipid oxidation (GO:0034440)2.97079317
91fatty acid catabolic process (GO:0009062)2.95749450
92positive regulation of lipid storage (GO:0010884)2.94767354
93regulation of B cell receptor signaling pathway (GO:0050855)2.94452146
94antigen processing and presentation of endogenous antigen (GO:0019883)2.93620233
95regulation of myeloid leukocyte mediated immunity (GO:0002886)2.93017543
96dendritic cell migration (GO:0036336)2.91902872
97negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.89521197
98L-phenylalanine catabolic process (GO:0006559)2.89142747
99erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.89142747
100phagocytosis, recognition (GO:0006910)2.88033022
101negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.87422464
102positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.86961051
103embryonic process involved in female pregnancy (GO:0060136)2.86813631
104valine metabolic process (GO:0006573)2.86685485
105lipid storage (GO:0019915)2.85554892
106* triglyceride metabolic process (GO:0006641)2.85188029
107gas transport (GO:0015669)2.84198301
108antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.83542614
109* triglyceride catabolic process (GO:0019433)2.82910406
110retina vasculature morphogenesis in camera-type eye (GO:0061299)2.80997366
111cellular response to arsenic-containing substance (GO:0071243)2.77138051
112interleukin-6-mediated signaling pathway (GO:0070102)2.76923492
113negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.76849076
114very long-chain fatty acid metabolic process (GO:0000038)2.74930334
115positive regulation of fatty acid oxidation (GO:0046321)2.74596080
116branched-chain amino acid catabolic process (GO:0009083)2.74589144
117multicellular organism reproduction (GO:0032504)2.74331529
118negative regulation of establishment of protein localization to plasma membrane (GO:0090005)2.73696027
119lipid particle organization (GO:0034389)2.71710377
120negative regulation of protein localization to plasma membrane (GO:1903077)2.71230895
121regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.71080174
122negative regulation of interleukin-17 production (GO:0032700)2.70669016
123cytokine secretion (GO:0050663)2.70584765
124negative regulation of lymphocyte mediated immunity (GO:0002707)2.70551676
125cholesterol biosynthetic process (GO:0006695)2.68924426
126antigen processing and presentation via MHC class Ib (GO:0002475)2.68617236
127axon ensheathment in central nervous system (GO:0032291)2.68532843
128central nervous system myelination (GO:0022010)2.68532843
129regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.68300011
130surfactant homeostasis (GO:0043129)2.68240621
131positive regulation of regulated secretory pathway (GO:1903307)2.64630347
132leukocyte aggregation (GO:0070486)2.64047820
133regulation of interleukin-8 biosynthetic process (GO:0045414)2.63824140
134response to phenylpropanoid (GO:0080184)2.63669486
135fusion of sperm to egg plasma membrane (GO:0007342)2.63226298
136protoporphyrinogen IX biosynthetic process (GO:0006782)2.62776579
137* acylglycerol metabolic process (GO:0006639)2.62758746
138myelin maintenance (GO:0043217)2.62712680
139hypotonic response (GO:0006971)2.62370732
140acylglycerol homeostasis (GO:0055090)2.62145544
141triglyceride homeostasis (GO:0070328)2.62145544
142negative regulation of interleukin-6 production (GO:0032715)2.61330046
143complement activation, alternative pathway (GO:0006957)2.61287735
144hepatocyte apoptotic process (GO:0097284)2.60396813
145L-phenylalanine metabolic process (GO:0006558)2.60292500
146erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.60292500
147negative regulation of glycoprotein metabolic process (GO:1903019)2.60164831
148response to lipoprotein particle (GO:0055094)2.59791389
149regulation of platelet aggregation (GO:0090330)2.59350264
150regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.57417681
151* neutral lipid metabolic process (GO:0006638)2.56598254
152ethanol metabolic process (GO:0006067)2.56573543
153carnitine metabolic process (GO:0009437)2.56274371
154superoxide anion generation (GO:0042554)2.56177045
155regulation of macrophage cytokine production (GO:0010935)2.56163833
156* positive regulation of lipid catabolic process (GO:0050996)2.55193536
157negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.55109150
158negative regulation of T-helper cell differentiation (GO:0045623)2.55109150
159quaternary ammonium group transport (GO:0015697)2.54514694
160negative regulation of erythrocyte differentiation (GO:0045647)2.54250267
161hydrogen peroxide biosynthetic process (GO:0050665)2.54145728
162positive regulation of toll-like receptor signaling pathway (GO:0034123)2.54113603
163long-chain fatty acid transport (GO:0015909)2.53797760
164positive regulation of interleukin-6 production (GO:0032755)2.53658591
165branched-chain amino acid metabolic process (GO:0009081)2.53372984
166intracellular lipid transport (GO:0032365)2.52817385
167creatine metabolic process (GO:0006600)2.52476268
168germinal center formation (GO:0002467)2.52395418
169* regulation of triglyceride catabolic process (GO:0010896)2.52266776
170glycerol metabolic process (GO:0006071)2.52248659
171myeloid leukocyte activation (GO:0002274)2.50965040
172regulation of gamma-delta T cell activation (GO:0046643)2.49870448
173negative regulation of T cell mediated immunity (GO:0002710)2.49622149
174negative regulation of lipase activity (GO:0060192)2.49530757
175erythrocyte development (GO:0048821)2.48554745
176heme transport (GO:0015886)2.48124223
177killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.48117762
178disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.48117762
179positive regulation of macrophage cytokine production (GO:0060907)2.47540463
180cell wall macromolecule metabolic process (GO:0044036)2.46342508
181cell wall macromolecule catabolic process (GO:0016998)2.46342508
182negative regulation of protein autophosphorylation (GO:0031953)2.46040970
183regulation of regulated secretory pathway (GO:1903305)2.45076055
184positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.44998622
185monocarboxylic acid catabolic process (GO:0072329)2.43277424
186membrane raft organization (GO:0031579)2.43100571
187* neutral lipid catabolic process (GO:0046461)2.43040507
188* acylglycerol catabolic process (GO:0046464)2.43040507
189NADP metabolic process (GO:0006739)2.42724741
190short-chain fatty acid metabolic process (GO:0046459)2.42505686
191import into cell (GO:0098657)2.41920808
192sulfur amino acid catabolic process (GO:0000098)2.41622940
193positive regulation of p38MAPK cascade (GO:1900745)2.41121410
194desmosome organization (GO:0002934)2.40594521
195growth hormone receptor signaling pathway (GO:0060396)2.39958486
196reproduction (GO:0000003)2.39289584
197adhesion of symbiont to host (GO:0044406)2.38882859
198triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.38618858

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.75595040
2TP63_17297297_ChIP-ChIP_HaCaT_Human4.61657939
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.18935998
4ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.74216558
5MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.25591944
6TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.06322670
7GATA1_22025678_ChIP-Seq_K562_Human3.04510901
8TRIM28_21343339_ChIP-Seq_HEK293_Human2.92783314
9RXR_22158963_ChIP-Seq_LIVER_Mouse2.91635386
10LXR_22158963_ChIP-Seq_LIVER_Mouse2.81653172
11EGR1_19374776_ChIP-ChIP_THP-1_Human2.79873996
12CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.76856457
13SMAD_19615063_ChIP-ChIP_OVARY_Human2.74086575
14TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.59167752
15PPARA_22158963_ChIP-Seq_LIVER_Mouse2.56175430
16STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.44409704
17SPI1_23547873_ChIP-Seq_NB4_Human2.44328061
18PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.42322514
19STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.41293377
20NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.38856545
21STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.34583193
22Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.30275411
23* EGR1_23403033_ChIP-Seq_LIVER_Mouse2.25947644
24SPI1_23127762_ChIP-Seq_K562_Human2.23210797
25FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.15950332
26IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.14765179
27* BRD4_27068464_Chip-Seq_AML-cells_Mouse2.05674003
28SCL_19346495_ChIP-Seq_HPC-7_Human2.00853859
29CDX2_19796622_ChIP-Seq_MESCs_Mouse1.99079349
30RARG_19884340_ChIP-ChIP_MEFs_Mouse1.97247004
31STAT4_19710469_ChIP-ChIP_TH1__Mouse1.83249544
32SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.73829671
33RUNX_20019798_ChIP-Seq_JUKART_Human1.73727440
34RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.71976532
35CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.70886865
36TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.68320657
37TFEB_21752829_ChIP-Seq_HELA_Human1.63780187
38* RUNX1_22412390_ChIP-Seq_EML_Mouse1.63366874
39ESR2_21235772_ChIP-Seq_MCF-7_Human1.60798879
40CJUN_26792858_Chip-Seq_BT549_Human1.60757676
41MYB_26560356_Chip-Seq_TH2_Human1.59928329
42TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.58581699
43PPAR_26484153_Chip-Seq_NCI-H1993_Human1.57148106
44GATA2_22383799_ChIP-Seq_G1ME_Mouse1.56040969
45SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.55243017
46* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.54748478
47* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.54748478
48MYB_26560356_Chip-Seq_TH1_Human1.53798697
49FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.52630339
50NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.51558992
51GATA2_21666600_ChIP-Seq_HMVEC_Human1.51441444
52ESR1_21235772_ChIP-Seq_MCF-7_Human1.50986428
53P63_26484246_Chip-Seq_KERATINOCYTES_Human1.48842154
54CLOCK_20551151_ChIP-Seq_293T_Human1.48082686
55CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.45741390
56VDR_24763502_ChIP-Seq_THP-1_Human1.44417712
57LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.43138605
58GATA1_19941827_ChIP-Seq_MEL_Mouse1.42244317
59ELF1_17652178_ChIP-ChIP_JURKAT_Human1.41547365
60PU_27001747_Chip-Seq_BMDM_Mouse1.41506034
61SOX2_20726797_ChIP-Seq_SW620_Human1.40100019
62FOXO3_23340844_ChIP-Seq_DLD1_Human1.40047647
63* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.39186370
64TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.37772683
65BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.37313098
66* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.37076338
67SALL4_18804426_ChIP-ChIP_XEN_Mouse1.36504562
68MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.35644579
69ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.34683421
70HOXB4_20404135_ChIP-ChIP_EML_Mouse1.33631078
71GATA1_22383799_ChIP-Seq_G1ME_Mouse1.32497661
72LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.30339007
73EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.30144668
74EP300_21415370_ChIP-Seq_HL-1_Mouse1.28553786
75FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.27300047
76IRF8_21731497_ChIP-ChIP_J774_Mouse1.26095287
77* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse1.25318603
78VDR_24787735_ChIP-Seq_THP-1_Human1.24896266
79SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.24572944
80GATA4_25053715_ChIP-Seq_YYC3_Human1.23250696
81NCOR1_26117541_ChIP-Seq_K562_Human1.22113124
82STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.21992715
83IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.21247064
84SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.21240969
85JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.20169308
86GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.19807362
87* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.19758917
88GATA3_26560356_Chip-Seq_TH2_Human1.18466249
89* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.18094141
90ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.16350553
91GATA3_27048872_Chip-Seq_THYMUS_Human1.15927709
92IRF8_27001747_Chip-Seq_BMDM_Mouse1.14956458
93SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.13213981
94FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.13138960
95SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.12507157
96SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.12507157
97CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.12497939
98ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.11638455
99ZNF217_24962896_ChIP-Seq_MCF-7_Human1.11617567
100MAF_26560356_Chip-Seq_TH1_Human1.10655741
101PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.10014410
102ESR1_20079471_ChIP-ChIP_T-47D_Human1.09692090
103RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.09680322
104* TP63_23658742_ChIP-Seq_EP156T_Human1.06819907
105PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.06490754
106* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.06237838
107SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.05544600
108FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.05400639
109NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.04589631
110TBX20_22328084_ChIP-Seq_HEART_Mouse1.03109938
111TBX20_22080862_ChIP-Seq_HEART_Mouse1.03109938
112GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.03077691
113ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.02943061
114JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.00364587
115FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.00158157
116E2F7_22180533_ChIP-Seq_HELA_Human1.00144605
117TP53_18474530_ChIP-ChIP_U2OS_Human1.00102909
118UTX_26944678_Chip-Seq_JUKART_Human1.00074522
119BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.99948491
120SALL4_22934838_ChIP-ChIP_CD34+_Human0.99877328
121* BRD4_25478319_ChIP-Seq_HGPS_Human0.99840497
122* MYB_21317192_ChIP-Seq_ERMYB_Mouse0.99291430
123BP1_19119308_ChIP-ChIP_Hs578T_Human0.96596438
124PIAS1_25552417_ChIP-Seq_VCAP_Human0.95601805
125SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.95459549
126CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95394365
127PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.94070665
128FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.93804686
129CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.93303603
130NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.93245620
131KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.91467374
132* KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.90983956
133SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.87685577
134FOXA2_19822575_ChIP-Seq_HepG2_Human0.87386956
135HIF1A_21447827_ChIP-Seq_MCF-7_Human0.82974240
136FOXM1_26456572_ChIP-Seq_MCF-7_Human0.82734877
137VDR_22108803_ChIP-Seq_LS180_Human0.82605987
138GATA3_24758297_ChIP-Seq_MCF-7_Human0.82337046
139CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.82299458
140STAT1_17558387_ChIP-Seq_HELA_Human0.82088293
141NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.81769260
142ER_23166858_ChIP-Seq_MCF-7_Human0.80041974
143IRF8_22096565_ChIP-ChIP_GC-B_Human0.79489690
144PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.79244476
145CEBPB_22108803_ChIP-Seq_LS180_Human0.78626677
146CDX2_22108803_ChIP-Seq_LS180_Human0.77219897
147AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.76560148
148RXR_22108803_ChIP-Seq_LS180_Human0.76550168
149AHR_22903824_ChIP-Seq_MCF-7_Human0.76130395
150ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.76076727
151* GATA2_19941826_ChIP-Seq_K562_Human0.75961703
152KLF5_25053715_ChIP-Seq_YYC3_Human0.74096973
153GATA1_19941826_ChIP-Seq_K562_Human0.74023265
154GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.73725413
155CBP_21632823_ChIP-Seq_H3396_Human0.73367930
156PCGF2_27294783_Chip-Seq_NPCs_Mouse0.73225089
157ZNF263_19887448_ChIP-Seq_K562_Human0.71994994
158RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.71905302
159UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.71731208
160FOXA1_25552417_ChIP-Seq_VCAP_Human0.71502678

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005670_abnormal_white_adipose3.77308301
2MP0008438_abnormal_cutaneous_collagen3.45378091
3MP0003303_peritoneal_inflammation2.87544129
4MP0005275_abnormal_skin_tensile2.83587066
5MP0003950_abnormal_plasma_membrane2.57275791
6MP0002796_impaired_skin_barrier2.54724247
7MP0005666_abnormal_adipose_tissue2.53380390
8MP0002139_abnormal_hepatobiliary_system2.49573742
9MP0003191_abnormal_cellular_cholesterol2.49074982
10MP0004130_abnormal_muscle_cell2.46630200
11MP0004185_abnormal_adipocyte_glucose2.46605410
12MP0005360_urolithiasis2.46170797
13MP0005410_abnormal_fertilization2.44408212
14MP0001881_abnormal_mammary_gland2.32257325
15MP0005464_abnormal_platelet_physiology2.25875793
16MP0001835_abnormal_antigen_presentation2.16138573
17MP0010329_abnormal_lipoprotein_level2.02627187
18MP0004272_abnormal_basement_membrane1.89135997
19MP0003724_increased_susceptibility_to1.88645834
20MP0003195_calcinosis1.86802846
21MP0003705_abnormal_hypodermis_morpholog1.86035426
22MP0005375_adipose_tissue_phenotype1.84914335
23MP0003300_gastrointestinal_ulcer1.83003862
24MP0004782_abnormal_surfactant_physiolog1.81946872
25MP0002118_abnormal_lipid_homeostasis1.79415252
26MP0005085_abnormal_gallbladder_physiolo1.77424512
27MP0005025_abnormal_response_to1.75815681
28MP0002060_abnormal_skin_morphology1.75545846
29MP0005365_abnormal_bile_salt1.74254041
30MP0002971_abnormal_brown_adipose1.74216726
31MP0003186_abnormal_redox_activity1.74156385
32MP0008004_abnormal_stomach_pH1.74004391
33MP0005451_abnormal_body_composition1.72964128
34MP0005083_abnormal_biliary_tract1.70327845
35MP0000579_abnormal_nail_morphology1.68023028
36MP0006082_CNS_inflammation1.67586277
37MP0004381_abnormal_hair_follicle1.67337383
38MP0000569_abnormal_digit_pigmentation1.66232217
39MP0002148_abnormal_hypersensitivity_rea1.64674117
40MP0000920_abnormal_myelination1.64414853
41MP0003011_delayed_dark_adaptation1.64295415
42MP0005000_abnormal_immune_tolerance1.63661430
43MP0003806_abnormal_nucleotide_metabolis1.59127198
44MP0000015_abnormal_ear_pigmentation1.58434693
45MP0010352_gastrointestinal_tract_polyps1.58018796
46MP0003690_abnormal_glial_cell1.57844403
47MP0001545_abnormal_hematopoietic_system1.56263125
48MP0005397_hematopoietic_system_phenotyp1.56263125
49MP0001800_abnormal_humoral_immune1.55404095
50MP0006054_spinal_hemorrhage1.55265360
51MP0002132_abnormal_respiratory_system1.54944213
52MP0009840_abnormal_foam_cell1.54394898
53MP0001958_emphysema1.51211458
54MP0005058_abnormal_lysosome_morphology1.49497170
55MP0002723_abnormal_immune_serum1.48980631
56MP0002452_abnormal_antigen_presenting1.47671605
57MP0004019_abnormal_vitamin_homeostasis1.45163292
58MP0002420_abnormal_adaptive_immunity1.44182537
59MP0003566_abnormal_cell_adhesion1.42439227
60MP0005501_abnormal_skin_physiology1.42361671
61MP0001819_abnormal_immune_cell1.41710353
62MP0004883_abnormal_blood_vessel1.41570378
63MP0000858_altered_metastatic_potential1.41217105
64MP0000343_altered_response_to1.40436571
65MP0003656_abnormal_erythrocyte_physiolo1.39777223
66MP0002877_abnormal_melanocyte_morpholog1.39429414
67MP0003453_abnormal_keratinocyte_physiol1.38809018
68MP0003436_decreased_susceptibility_to1.34886120
69MP0000465_gastrointestinal_hemorrhage1.34505451
70MP0010678_abnormal_skin_adnexa1.33587782
71MP0000383_abnormal_hair_follicle1.33351843
72MP0000647_abnormal_sebaceous_gland1.32964818
73MP0000685_abnormal_immune_system1.31388407
74MP0001533_abnormal_skeleton_physiology1.30716356
75MP0003221_abnormal_cardiomyocyte_apopto1.30130950
76MP0005334_abnormal_fat_pad1.29636500
77MP0001661_extended_life_span1.24626605
78MP0001845_abnormal_inflammatory_respons1.24290702
79MP0001216_abnormal_epidermal_layer1.21055091
80MP0002405_respiratory_system_inflammati1.20978091
81MP0005387_immune_system_phenotype1.19810697
82MP0001790_abnormal_immune_system1.19810697
83MP0002837_dystrophic_cardiac_calcinosis1.19249428
84MP0002398_abnormal_bone_marrow1.18966292
85MP0008875_abnormal_xenobiotic_pharmacok1.17199442
86MP0002332_abnormal_exercise_endurance1.16367312
87MP0003045_fibrosis1.15795531
88MP0000003_abnormal_adipose_tissue1.14244081
89MP0000566_synostosis1.12323029
90MP0005164_abnormal_response_to1.09985051
91MP0001851_eye_inflammation1.08787707
92MP0000609_abnormal_liver_physiology1.08746005
93MP0002722_abnormal_immune_system1.08735980
94MP0002295_abnormal_pulmonary_circulatio1.08292653
95MP0004147_increased_porphyrin_level1.07317259
96MP0002419_abnormal_innate_immunity1.06836816
97MP0005075_abnormal_melanosome_morpholog1.06596021
98MP0002098_abnormal_vibrissa_morphology1.05923656
99MP0005332_abnormal_amino_acid1.05288012
100MP0000716_abnormal_immune_system1.04570490
101MP0010234_abnormal_vibrissa_follicle1.03110258
102MP0008469_abnormal_protein_level1.02879823
103MP0000427_abnormal_hair_cycle1.01408168
104MP0000689_abnormal_spleen_morphology1.00839109
105MP0008260_abnormal_autophagy1.00654285
106MP0009764_decreased_sensitivity_to0.99952215
107MP0009115_abnormal_fat_cell0.99921191
108MP0003828_pulmonary_edema0.99176778
109MP0000377_abnormal_hair_follicle0.98360935
110MP0003172_abnormal_lysosome_physiology0.98128090
111MP0004947_skin_inflammation0.97431689
112MP0004233_abnormal_muscle_weight0.97339001
113MP0005388_respiratory_system_phenotype0.97295521
114MP0002133_abnormal_respiratory_system0.97295521
115MP0005584_abnormal_enzyme/coenzyme_acti0.95695215
116MP0010771_integument_phenotype0.95212732
117MP0005174_abnormal_tail_pigmentation0.94873710
118MP0001542_abnormal_bone_strength0.94275362
119MP0002429_abnormal_blood_cell0.94245236
120MP0009384_cardiac_valve_regurgitation0.92648272
121MP0005671_abnormal_response_to0.92252875
122MP0009785_altered_susceptibility_to0.90885997
123MP0009333_abnormal_splenocyte_physiolog0.88984824
124MP0003075_altered_response_to0.88522939
125MP0010155_abnormal_intestine_physiology0.88142338
126MP0009643_abnormal_urine_homeostasis0.87985673
127MP0002095_abnormal_skin_pigmentation0.87622921
128MP0001879_abnormal_lymphatic_vessel0.87496213
129MP0005319_abnormal_enzyme/_coenzyme0.87141968
130MP0009278_abnormal_bone_marrow0.85698053
131MP0003252_abnormal_bile_duct0.84606733
132MP0009931_abnormal_skin_appearance0.84195890
133MP0005623_abnormal_meninges_morphology0.83503798
134MP0005076_abnormal_cell_differentiation0.80343820
135MP0003763_abnormal_thymus_physiology0.79814212
136MP0002998_abnormal_bone_remodeling0.78576668
137MP0005023_abnormal_wound_healing0.77212926
138MP0008775_abnormal_heart_ventricle0.76732987
139MP0001243_abnormal_dermal_layer0.76697668
140MP0001853_heart_inflammation0.76613112
141MP0000371_diluted_coat_color0.76159268
142MP0002254_reproductive_system_inflammat0.75294570
143MP0001666_abnormal_nutrient_absorption0.74987718
144MP0001177_atelectasis0.73968703
145MP0001191_abnormal_skin_condition0.73572446
146MP0005408_hypopigmentation0.72410089
147MP0000627_abnormal_mammary_gland0.71774440
148MP0009765_abnormal_xenobiotic_induced0.71263553
149MP0003136_yellow_coat_color0.70676558
150MP0005390_skeleton_phenotype0.70603462
151MP0000604_amyloidosis0.70403761
152MP0002168_other_aberrant_phenotype0.70322229
153MP0002396_abnormal_hematopoietic_system0.69248876
154MP0002970_abnormal_white_adipose0.68972805
155MP0005171_absent_coat_pigmentation0.68937935
156MP0009763_increased_sensitivity_to0.68438450
157MP0003448_altered_tumor_morphology0.68047363
158MP0006138_congestive_heart_failure0.67988787

Predicted human phenotypes

RankGene SetZ-score
1Increased IgE level (HP:0003212)4.29229253
2Abnormality of the heme biosynthetic pathway (HP:0010472)4.16207041
3Myositis (HP:0100614)3.96803308
4Orchitis (HP:0100796)3.91710057
5Axonal loss (HP:0003447)3.74773656
6Spontaneous hematomas (HP:0007420)3.69442430
7Optic neuritis (HP:0100653)3.67236168
8Retrobulbar optic neuritis (HP:0100654)3.67236168
9Hypochromic microcytic anemia (HP:0004840)3.58158472
10Gingival bleeding (HP:0000225)3.57921708
11Parakeratosis (HP:0001036)3.56488335
12Poikilocytosis (HP:0004447)3.51334341
13Acanthosis nigricans (HP:0000956)3.49471447
14Xanthomatosis (HP:0000991)3.48056555
15Polycythemia (HP:0001901)3.46029552
16Stomatitis (HP:0010280)3.45154104
17Recurrent gram-negative bacterial infections (HP:0005420)3.36801157
18Prolonged bleeding time (HP:0003010)3.36037560
19Petechiae (HP:0000967)3.30925594
20Microcytic anemia (HP:0001935)3.30856601
21Abnormality of nail color (HP:0100643)3.26571461
22Keratoconjunctivitis sicca (HP:0001097)3.24268903
23Hyperlipoproteinemia (HP:0010980)3.19936196
24Eczematoid dermatitis (HP:0000976)3.13504362
25Right ventricular cardiomyopathy (HP:0011663)3.06567993
26Acanthocytosis (HP:0001927)3.06545400
27Epistaxis (HP:0000421)3.06063357
28Hyporeflexia of lower limbs (HP:0002600)3.03587335
29Premature rupture of membranes (HP:0001788)2.99491272
30Gastrointestinal infarctions (HP:0005244)2.97585561
31Recurrent skin infections (HP:0001581)2.96868746
32Myocardial infarction (HP:0001658)2.96542215
33Elevated erythrocyte sedimentation rate (HP:0003565)2.95326344
34Gangrene (HP:0100758)2.94052009
35Keratoconjunctivitis (HP:0001096)2.90015322
36Epidermoid cyst (HP:0200040)2.88485308
37Abnormality of serine family amino acid metabolism (HP:0010894)2.86429765
38Abnormality of glycine metabolism (HP:0010895)2.86429765
39Neurofibrillary tangles (HP:0002185)2.86215924
40Muscle fiber splitting (HP:0003555)2.86154724
41Hyperglycinuria (HP:0003108)2.84129889
42Abnormality of fatty-acid metabolism (HP:0004359)2.78670031
43Vascular calcification (HP:0004934)2.78387268
44Hydroxyprolinuria (HP:0003080)2.77125030
45Abnormality of proline metabolism (HP:0010907)2.77125030
46Abnormal hemoglobin (HP:0011902)2.76825024
47Chronic obstructive pulmonary disease (HP:0006510)2.76787384
48Obstructive lung disease (HP:0006536)2.76787384
49Cardiovascular calcification (HP:0011915)2.71750139
50Abnormal platelet volume (HP:0011876)2.71454606
51Pustule (HP:0200039)2.69952675
52* Congenital ichthyosiform erythroderma (HP:0007431)2.63178854
53Hemorrhage of the eye (HP:0011885)2.62980725
54Anorexia (HP:0002039)2.62505967
55Hypertriglyceridemia (HP:0002155)2.62288621
56Complement deficiency (HP:0004431)2.58029702
57Abnormality of macrophages (HP:0004311)2.55132934
58Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.54777802
59Osteolytic defects of the hand bones (HP:0009699)2.54298411
60Osteolytic defects of the phalanges of the hand (HP:0009771)2.54298411
61Hypoalphalipoproteinemia (HP:0003233)2.53407322
62Erythema (HP:0010783)2.50620394
63Recurrent abscess formation (HP:0002722)2.49838644
64Vacuolated lymphocytes (HP:0001922)2.49473901
65Hypoglycemic coma (HP:0001325)2.46050720
66Arterial thrombosis (HP:0004420)2.45385528
67Recurrent bacterial skin infections (HP:0005406)2.44806102
68Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.44591196
69Episodic fever (HP:0001954)2.44429232
70Intrahepatic cholestasis (HP:0001406)2.44321855
71Hepatosplenomegaly (HP:0001433)2.43375638
72Thick nail (HP:0001805)2.41121526
73Recurrent fungal infections (HP:0002841)2.40880428
74Increased mean platelet volume (HP:0011877)2.40205525
75Increased serum ferritin (HP:0003281)2.37640998
76Abnormality of iron homeostasis (HP:0011031)2.36509991
77Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.35997091
78Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.35891924
79Dicarboxylic aciduria (HP:0003215)2.34652559
80Abnormality of dicarboxylic acid metabolism (HP:0010995)2.34652559
81Deep venous thrombosis (HP:0002625)2.32824855
82Hypoplasia of the iris (HP:0007676)2.32560438
83Hypophosphatemic rickets (HP:0004912)2.31803098
84Tetraparesis (HP:0002273)2.31789405
85Hypercholesterolemia (HP:0003124)2.30530462
86Conjunctival telangiectasia (HP:0000524)2.28707327
87Abnormality of the vasculature of the conjunctiva (HP:0008054)2.27984891
88Hypochromic anemia (HP:0001931)2.26528023
89Amyloidosis (HP:0011034)2.24923677
90Menorrhagia (HP:0000132)2.23928554
91Abnormal delayed hypersensitivity skin test (HP:0002963)2.23269750
92Insulin-resistant diabetes mellitus (HP:0000831)2.22475209
93Onycholysis (HP:0001806)2.21705614
94Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.20871578
95Abnormality of purine metabolism (HP:0004352)2.20785229
96Abnormality of glutamine family amino acid metabolism (HP:0010902)2.20711394
97Hypergammaglobulinemia (HP:0010702)2.19969512
98Stridor (HP:0010307)2.18726220
99Nausea (HP:0002018)2.15673377
100Segmental peripheral demyelination/remyelination (HP:0003481)2.14237554
101Encephalitis (HP:0002383)2.13920073
102Peripheral demyelination (HP:0011096)2.12424903
103Osteomyelitis (HP:0002754)2.12072597
104Myoglobinuria (HP:0002913)2.11881976
105Abnormality of complement system (HP:0005339)2.11062074
106Vasculitis (HP:0002633)2.07744154
107Ileus (HP:0002595)2.07716254
108T lymphocytopenia (HP:0005403)2.05883526
109Respiratory distress (HP:0002098)2.05822779
110Papillary thyroid carcinoma (HP:0002895)2.05566005
111Ketosis (HP:0001946)2.05439636
112Increased connective tissue (HP:0009025)2.04198396
113Abnormality of aromatic amino acid family metabolism (HP:0004338)2.03887939
114Rhabdomyolysis (HP:0003201)2.02501546
115Abnormality of T cell number (HP:0011839)2.02080498
116Hyperammonemia (HP:0001987)2.00239167
117Chronic mucocutaneous candidiasis (HP:0002728)1.99222432
118Recurrent cutaneous fungal infections (HP:0011370)1.99222432
119Autoimmune hemolytic anemia (HP:0001890)1.98574454
120Toxemia of pregnancy (HP:0100603)1.98504963
121Albinism (HP:0001022)1.97024447
122Paralysis (HP:0003470)1.95913069
123Conjunctival hamartoma (HP:0100780)1.95197566
124Onion bulb formation (HP:0003383)1.94254318
125Tubulointerstitial fibrosis (HP:0005576)1.94129309
126Dynein arm defect of respiratory motile cilia (HP:0012255)1.93873951
127Absent/shortened dynein arms (HP:0200106)1.93873951
128Systemic lupus erythematosus (HP:0002725)1.93754263
129Chest pain (HP:0100749)1.93712580
130Mediastinal lymphadenopathy (HP:0100721)1.93198862
131Abnormality of the common coagulation pathway (HP:0010990)1.92100122
132Pulmonary infiltrates (HP:0002113)1.91885846
133Difficulty running (HP:0009046)1.91593504
134Hypotrichosis (HP:0001006)1.91176955
135Sensory axonal neuropathy (HP:0003390)1.91126770
136Hemoptysis (HP:0002105)1.90893568
137Abnormality of transition element cation homeostasis (HP:0011030)1.90768770
138Leukocytosis (HP:0001974)1.90276166
139Pulmonary embolism (HP:0002204)1.88060988
140Impaired platelet aggregation (HP:0003540)1.87766389
141Abnormal platelet function (HP:0011869)1.87766389
142Glomerulopathy (HP:0100820)1.86532518
143Palmoplantar hyperkeratosis (HP:0000972)1.85398810
144Skin ulcer (HP:0200042)1.84917572
145* Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.83767368
146Increased IgM level (HP:0003496)1.82745152
147Protuberant abdomen (HP:0001538)1.82124440
148Abnormality of liposaccharide metabolism (HP:0010968)1.81932790
149Abnormality of glycosphingolipid metabolism (HP:0004343)1.81932790
150Abnormality of glycolipid metabolism (HP:0010969)1.81932790
151Hyperglycinemia (HP:0002154)1.81392233
152Pancreatitis (HP:0001733)1.79807643
153Oral leukoplakia (HP:0002745)1.79472112
154Periodontitis (HP:0000704)1.79208107
155Abnormality of pyrimidine metabolism (HP:0004353)1.78992393
156Acne (HP:0001061)1.77868477
157Follicular hyperkeratosis (HP:0007502)1.76730829
158Ventricular tachycardia (HP:0004756)1.75892527
159Cerebral inclusion bodies (HP:0100314)1.75120149
160Nephritis (HP:0000123)1.72791923
161Joint hemorrhage (HP:0005261)1.71883081
162Abnormal tarsal ossification (HP:0008369)1.70852407
163Femoral bowing (HP:0002980)1.70349039
164Spinal rigidity (HP:0003306)1.69918730
165Peritonitis (HP:0002586)1.68671677
166Exercise-induced muscle cramps (HP:0003710)1.68135477
167Cupped ribs (HP:0000887)1.67974309
168Erythroderma (HP:0001019)1.66278846
169Premature skin wrinkling (HP:0100678)1.63933448
170Bone cyst (HP:0012062)1.63413939
171Difficulty walking (HP:0002355)1.63404863
172Urticaria (HP:0001025)1.62427046
173Bell-shaped thorax (HP:0001591)1.61728112
174Ketoacidosis (HP:0001993)1.61693753
175Prolonged neonatal jaundice (HP:0006579)1.61635383
176Skin nodule (HP:0200036)1.61621724
177Gingivitis (HP:0000230)1.61451312
178Hypolipoproteinemia (HP:0010981)1.61430328
179Oligomenorrhea (HP:0000876)1.61315032
180Prolonged partial thromboplastin time (HP:0003645)1.60966388

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK43.66360803
2PDK33.30105119
3PDK43.30105119
4PDK23.19145952
5SIK13.14615441
6CAMK1D3.01125878
7STK392.99222648
8PBK2.65544260
9EPHB12.61790260
10KSR22.55956205
11BCKDK2.45601675
12MAP3K22.45232402
13TYK22.41277285
14TESK12.34148162
15BMPR22.20051889
16TRPM72.16621339
17MST1R2.12896587
18ZAP702.05254360
19MET2.03030266
20WNK41.94287767
21CAMK1G1.94146875
22MAP3K31.89850363
23EIF2AK11.85189977
24ACVR1B1.84998420
25GRK61.82541339
26PIK3CA1.78780804
27FGFR21.78340580
28JAK21.76980797
29TAOK31.71538433
30TRIB31.69830368
31JAK31.62918440
32MAP3K11.59020694
33TTN1.57118617
34MAP3K121.57084267
35MAP3K61.55849401
36TAOK11.53215139
37RAF11.50037485
38ERN11.48514657
39PIK3CG1.46210522
40PRPF4B1.45002414
41EPHA31.44869994
42IRAK41.43466293
43TIE11.38313090
44STK381.37759340
45LIMK11.35371405
46KSR11.35076840
47INSRR1.30983857
48STK241.29661341
49TAOK21.29315020
50HCK1.28757227
51IRAK11.26867271
52PKN11.24680190
53MAPKAPK51.24182021
54MARK31.22366796
55SIK31.20992354
56TGFBR21.16394568
57IKBKE1.15672618
58OXSR11.15415916
59MAP3K141.14368425
60NEK91.14091618
61RIPK11.06762530
62BTK1.06023008
63TEC1.05117221
64PRKAA21.04008952
65FRK1.01234125
66MAP3K51.00956588
67LMTK21.00682189
68FES0.98818687
69YES10.98750376
70ABL20.94707163
71EIF2AK20.89118401
72EPHB20.86239053
73BCR0.84904932
74GSK3A0.84690854
75SGK2230.83571947
76SGK4940.83571947
77LATS10.83137312
78IKBKB0.82155103
79TBK10.82124301
80PTK2B0.82009094
81LYN0.81454954
82DYRK30.81000252
83SYK0.80474787
84ERBB40.80368730
85PIM10.79817723
86STK30.79760814
87OBSCN0.79003419
88MAP2K30.78619982
89IRAK20.77503171
90PDGFRB0.76803908
91PDPK10.73971166
92MAP2K10.73613325
93IRAK30.73424135
94BMX0.72132482
95PIM20.71661341
96CLK10.70819809
97WNK10.70521658
98FGFR40.70103995
99STK40.69581293
100MOS0.69254006
101MATK0.67330614
102PAK40.66522803
103FER0.64163601
104BMPR1B0.63141605
105GRK10.62511003
106BLK0.62254245
107DDR20.62140725
108PRKD10.61245676
109ZAK0.58593933
110STK100.55151742
111MAP3K80.54035753
112PTK60.52645988
113PRKCE0.52038290
114EIF2AK30.51729010
115TNK20.51689893
116TXK0.50558851
117ILK0.50495369
118LCK0.49818961
119MAPK120.49799059
120CDK60.49674185
121CSK0.49592359
122SGK30.48979174
123STK38L0.48484886
124ERBB30.48312234
125CAMK2D0.48088615
126RET0.47491489
127FGR0.47304779
128PHKG20.47258139
129PHKG10.47258139
130PINK10.46300398
131MAP2K40.46147680
132GRK50.46088299
133PRKAA10.45918367
134ABL10.45850134
135MST40.45203288
136PRKG20.44896603
137JAK10.43457152
138MAP4K10.42977319
139PRKCQ0.42475608
140GRK70.42019885
141PDK10.39552962
142MYLK0.38711555
143DYRK20.38705463
144PRKACG0.37965706
145MAPK40.37438996
146DAPK30.37093278
147TESK20.37004702
148NLK0.36821396
149LRRK20.36323693
150KDR0.35858698
151ADRBK10.35137652
152NME20.34624598
153MAPKAPK20.34521630
154NEK60.34382600
155MAP3K110.30817800
156FGFR30.30761780
157SGK20.30753744
158AKT30.28496200
159TRIM280.28299775

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000613.61659320
2Propanoate metabolism_Homo sapiens_hsa006403.22404334
3Caffeine metabolism_Homo sapiens_hsa002322.87062574
4Fatty acid elongation_Homo sapiens_hsa000622.80257071
5Osteoclast differentiation_Homo sapiens_hsa043802.79746515
6Steroid biosynthesis_Homo sapiens_hsa001002.77676313
7Fatty acid metabolism_Homo sapiens_hsa012122.76436465
8PPAR signaling pathway_Homo sapiens_hsa033202.74668994
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.54326938
10Fatty acid degradation_Homo sapiens_hsa000712.50113000
11Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.35302601
12NOD-like receptor signaling pathway_Homo sapiens_hsa046212.34638682
13Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.04125605
14Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.90750396
15Acute myeloid leukemia_Homo sapiens_hsa052211.89094894
16Peroxisome_Homo sapiens_hsa041461.85938378
17Pyruvate metabolism_Homo sapiens_hsa006201.75441841
18Staphylococcus aureus infection_Homo sapiens_hsa051501.73519007
19Histidine metabolism_Homo sapiens_hsa003401.73092533
20beta-Alanine metabolism_Homo sapiens_hsa004101.70548257
21Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.66646170
22Primary bile acid biosynthesis_Homo sapiens_hsa001201.66085852
23Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.65600338
24Measles_Homo sapiens_hsa051621.65203521
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.63570706
26B cell receptor signaling pathway_Homo sapiens_hsa046621.59629025
27Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.57041805
28Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.54504788
29Influenza A_Homo sapiens_hsa051641.54369911
30Jak-STAT signaling pathway_Homo sapiens_hsa046301.53948726
31Shigellosis_Homo sapiens_hsa051311.53684790
32alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.51639154
33Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.51533878
34Complement and coagulation cascades_Homo sapiens_hsa046101.48369369
35Glycerolipid metabolism_Homo sapiens_hsa005611.47913158
36Hematopoietic cell lineage_Homo sapiens_hsa046401.45647982
37Pancreatic cancer_Homo sapiens_hsa052121.45295702
38TNF signaling pathway_Homo sapiens_hsa046681.43104913
39Chemokine signaling pathway_Homo sapiens_hsa040621.42479383
40Butanoate metabolism_Homo sapiens_hsa006501.41873345
41Nitrogen metabolism_Homo sapiens_hsa009101.41742316
42Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.41233926
43Platelet activation_Homo sapiens_hsa046111.39726181
44Sulfur metabolism_Homo sapiens_hsa009201.39381147
45Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.39329363
46Vitamin B6 metabolism_Homo sapiens_hsa007501.38102189
47Chronic myeloid leukemia_Homo sapiens_hsa052201.36286735
48Renal cell carcinoma_Homo sapiens_hsa052111.35028806
49Linoleic acid metabolism_Homo sapiens_hsa005911.33020991
50Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.31407182
51Fat digestion and absorption_Homo sapiens_hsa049751.31363530
52Collecting duct acid secretion_Homo sapiens_hsa049661.31240823
53Hepatitis B_Homo sapiens_hsa051611.29152407
54Chemical carcinogenesis_Homo sapiens_hsa052041.29052931
55Tryptophan metabolism_Homo sapiens_hsa003801.27916533
56Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.26574510
57Retinol metabolism_Homo sapiens_hsa008301.26166952
58Non-small cell lung cancer_Homo sapiens_hsa052231.25372326
59NF-kappa B signaling pathway_Homo sapiens_hsa040641.19918858
60RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.19865140
61* Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.19848796
62Phenylalanine metabolism_Homo sapiens_hsa003601.18539186
63Ether lipid metabolism_Homo sapiens_hsa005651.14108695
64Glutathione metabolism_Homo sapiens_hsa004801.13609949
65Apoptosis_Homo sapiens_hsa042101.13516201
66Sphingolipid metabolism_Homo sapiens_hsa006001.11643369
67Steroid hormone biosynthesis_Homo sapiens_hsa001401.10901066
68Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.10467341
69Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.10026545
70Sphingolipid signaling pathway_Homo sapiens_hsa040711.09319692
71Pentose and glucuronate interconversions_Homo sapiens_hsa000401.07436726
72Carbon metabolism_Homo sapiens_hsa012001.07230012
73Arachidonic acid metabolism_Homo sapiens_hsa005901.06962674
74Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.05329918
75African trypanosomiasis_Homo sapiens_hsa051431.02904186
76Tyrosine metabolism_Homo sapiens_hsa003501.00464050
77Dorso-ventral axis formation_Homo sapiens_hsa043201.00435452
78Herpes simplex infection_Homo sapiens_hsa051680.99975052
79ABC transporters_Homo sapiens_hsa020100.99365995
80Phagosome_Homo sapiens_hsa041450.97544256
81AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.96345233
82Thyroid cancer_Homo sapiens_hsa052160.95374304
83Vitamin digestion and absorption_Homo sapiens_hsa049770.95120872
84ECM-receptor interaction_Homo sapiens_hsa045120.94622535
85Lysosome_Homo sapiens_hsa041420.93661879
86VEGF signaling pathway_Homo sapiens_hsa043700.93571014
87Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.92088332
88Adipocytokine signaling pathway_Homo sapiens_hsa049200.91981193
89Prolactin signaling pathway_Homo sapiens_hsa049170.91753417
90Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.90674550
91Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.89590405
92Endocytosis_Homo sapiens_hsa041440.88112570
93T cell receptor signaling pathway_Homo sapiens_hsa046600.87396374
94HIF-1 signaling pathway_Homo sapiens_hsa040660.86372649
95Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.85588404
96Starch and sucrose metabolism_Homo sapiens_hsa005000.85450357
97FoxO signaling pathway_Homo sapiens_hsa040680.85026685
98Malaria_Homo sapiens_hsa051440.84082812
99Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.81280831
100Endometrial cancer_Homo sapiens_hsa052130.81248709
101Arginine biosynthesis_Homo sapiens_hsa002200.80701348
102Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.77672243
103Viral carcinogenesis_Homo sapiens_hsa052030.72797716
104Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.71688898
1052-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.71104380
106Bladder cancer_Homo sapiens_hsa052190.69643741
107Pentose phosphate pathway_Homo sapiens_hsa000300.68347727
108Prostate cancer_Homo sapiens_hsa052150.67991049
109Regulation of autophagy_Homo sapiens_hsa041400.65330970
110Viral myocarditis_Homo sapiens_hsa054160.65184369
111Rheumatoid arthritis_Homo sapiens_hsa053230.64855541
112Glycerophospholipid metabolism_Homo sapiens_hsa005640.63607535
113Glycosaminoglycan degradation_Homo sapiens_hsa005310.63604638
114Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.63377663
115Neurotrophin signaling pathway_Homo sapiens_hsa047220.62781953
116Arginine and proline metabolism_Homo sapiens_hsa003300.62779341
117AMPK signaling pathway_Homo sapiens_hsa041520.62167706
118Amoebiasis_Homo sapiens_hsa051460.60195028
119Inositol phosphate metabolism_Homo sapiens_hsa005620.60001763
120Mineral absorption_Homo sapiens_hsa049780.59565442
121Phosphatidylinositol signaling system_Homo sapiens_hsa040700.58195401
122Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.56537198
123Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.56461926
124Insulin resistance_Homo sapiens_hsa049310.51709118
125Phospholipase D signaling pathway_Homo sapiens_hsa040720.50278563
126p53 signaling pathway_Homo sapiens_hsa041150.50260382
127Folate biosynthesis_Homo sapiens_hsa007900.49740401
128mTOR signaling pathway_Homo sapiens_hsa041500.46975322
129Vibrio cholerae infection_Homo sapiens_hsa051100.46829552
130Glioma_Homo sapiens_hsa052140.46738420
131Choline metabolism in cancer_Homo sapiens_hsa052310.45998357
132Small cell lung cancer_Homo sapiens_hsa052220.44829031
133Metabolic pathways_Homo sapiens_hsa011000.44552015
134ErbB signaling pathway_Homo sapiens_hsa040120.44076873
135Regulation of actin cytoskeleton_Homo sapiens_hsa048100.44016839
136GnRH signaling pathway_Homo sapiens_hsa049120.42779909
137Pertussis_Homo sapiens_hsa051330.42200915
138Bile secretion_Homo sapiens_hsa049760.40564603
139Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.40424911
140SNARE interactions in vesicular transport_Homo sapiens_hsa041300.40302988
141Leishmaniasis_Homo sapiens_hsa051400.40249007
142Leukocyte transendothelial migration_Homo sapiens_hsa046700.39325839
143Ovarian steroidogenesis_Homo sapiens_hsa049130.36731852
144Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.35767993
145Other glycan degradation_Homo sapiens_hsa005110.35199466
146Toxoplasmosis_Homo sapiens_hsa051450.30717801
147Protein digestion and absorption_Homo sapiens_hsa049740.30666374
148Legionellosis_Homo sapiens_hsa051340.29335222
149Focal adhesion_Homo sapiens_hsa045100.27697832
150Tuberculosis_Homo sapiens_hsa051520.24526225
151Tight junction_Homo sapiens_hsa045300.24135123
152Galactose metabolism_Homo sapiens_hsa000520.23659951
153Drug metabolism - other enzymes_Homo sapiens_hsa009830.21432788
154Renin-angiotensin system_Homo sapiens_hsa046140.21034879
155Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.20819088
156Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.20253888
157Hepatitis C_Homo sapiens_hsa051600.19578984
158Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.19499627
159Salmonella infection_Homo sapiens_hsa051320.19463597
160Sulfur relay system_Homo sapiens_hsa041220.18272624
161Toll-like receptor signaling pathway_Homo sapiens_hsa046200.17987013
162Selenocompound metabolism_Homo sapiens_hsa004500.16467436
163Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.16427968

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »