ABI1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the Abelson-interactor family of adaptor proteins. These proteins facilitate signal transduction as components of several multiprotein complexes, and regulate actin polymerization and cytoskeletal remodeling through interactions with Abelson tyrosine kinases. The encoded protein plays a role in macropinocytosis as a component of the WAVE2 complex, and also forms a complex with EPS8 and SOS1 that mediates signal transduction from Ras to Rac. This gene may play a role in the progression of several malignancies including melanoma, colon cancer and breast cancer, and a t(10;11) chromosomal translocation involving this gene and the MLL gene has been associated with acute myeloid leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 14. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of cell killing (GO:0031342)5.13141335
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.13141335
3antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.90645416
4positive regulation by symbiont of host defense response (GO:0052509)4.88133715
5modulation by symbiont of host defense response (GO:0052031)4.88133715
6modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.88133715
7modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.88133715
8positive regulation by organism of defense response of other organism involved in symbiotic interact4.88133715
9modulation by symbiont of host immune response (GO:0052553)4.88133715
10regulation of B cell receptor signaling pathway (GO:0050855)4.41779659
11negative regulation of interleukin-12 production (GO:0032695)4.07147094
12macrophage activation involved in immune response (GO:0002281)4.02285274
13positive regulation of gamma-delta T cell activation (GO:0046645)4.00166529
14regulation of interferon-beta biosynthetic process (GO:0045357)3.99516204
15regulation of T-helper 1 cell differentiation (GO:0045625)3.96737215
16microglial cell activation (GO:0001774)3.87502100
17neutrophil activation involved in immune response (GO:0002283)3.87380026
18myeloid cell activation involved in immune response (GO:0002275)3.36646365
19response to peptidoglycan (GO:0032494)3.34741741
20positive regulation of interferon-alpha production (GO:0032727)3.33955685
21detection of other organism (GO:0098543)3.32901121
22B cell mediated immunity (GO:0019724)3.27896211
23positive regulation of type 2 immune response (GO:0002830)3.26025408
24macrophage activation (GO:0042116)3.23425118
25regulation of chronic inflammatory response (GO:0002676)3.23389012
26response to host immune response (GO:0052572)3.22356920
27response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.22356920
28regulation of interferon-alpha production (GO:0032647)3.20639614
29positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.20485468
30granulocyte activation (GO:0036230)3.20202522
31positive regulation of cellular amide metabolic process (GO:0034250)3.19000585
32regulation of tolerance induction (GO:0002643)3.17930228
33detection of bacterium (GO:0016045)3.13866033
34positive regulation of tolerance induction (GO:0002645)3.10941631
35antigen processing and presentation of endogenous antigen (GO:0019883)3.10875459
36regulation of interleukin-12 biosynthetic process (GO:0045075)3.10108067
37interferon-gamma-mediated signaling pathway (GO:0060333)3.10092742
38negative regulation of interleukin-17 production (GO:0032700)3.07673751
39positive regulation of antigen processing and presentation (GO:0002579)3.06921881
40response to host (GO:0075136)3.06788477
41response to host defenses (GO:0052200)3.06788477
42response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.06788477
43lipopolysaccharide-mediated signaling pathway (GO:0031663)3.06608617
44positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.05834696
45neutrophil activation (GO:0042119)3.04567714
46positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.01600812
47positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.01272013
48B cell receptor signaling pathway (GO:0050853)2.99727536
49Arp2/3 complex-mediated actin nucleation (GO:0034314)2.97852437
50regulation of regulatory T cell differentiation (GO:0045589)2.97808909
51immunoglobulin mediated immune response (GO:0016064)2.94987146
52antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.94928477
53antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.94928477
54respiratory burst (GO:0045730)2.91832148
55positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.90561646
56defense response to protozoan (GO:0042832)2.86871117
57response to muramyl dipeptide (GO:0032495)2.86420835
58regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.85716029
59T cell migration (GO:0072678)2.84474244
60leukocyte aggregation (GO:0070486)2.83797436
61negative regulation of T cell mediated immunity (GO:0002710)2.82375610
62regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.81112689
63regulation of dendritic cell antigen processing and presentation (GO:0002604)2.80784235
64positive regulation of interleukin-1 beta secretion (GO:0050718)2.79657899
65regulation of interleukin-12 production (GO:0032655)2.79460318
66regulation of vitamin D biosynthetic process (GO:0060556)2.78215273
67response to protozoan (GO:0001562)2.77970528
68regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.76454665
69mast cell activation (GO:0045576)2.76072415
70positive regulation of interleukin-17 production (GO:0032740)2.75025219
71positive regulation of T-helper cell differentiation (GO:0045624)2.74960126
72detection of external biotic stimulus (GO:0098581)2.73394461
73regulation of T-helper cell differentiation (GO:0045622)2.72982739
74positive regulation of toll-like receptor signaling pathway (GO:0034123)2.71835995
75regulation of interleukin-1 beta secretion (GO:0050706)2.68542310
76myeloid leukocyte activation (GO:0002274)2.68376643
77dendritic cell chemotaxis (GO:0002407)2.68162231
78cellular response to interferon-gamma (GO:0071346)2.67931921
79regulation of type 2 immune response (GO:0002828)2.67831522
80regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.67160330
81regulation of gamma-delta T cell differentiation (GO:0045586)2.65326934
82regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.65216612
83negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.65043173
84hepatocyte apoptotic process (GO:0097284)2.64521646
85dendritic cell migration (GO:0036336)2.64181721
86negative thymic T cell selection (GO:0045060)2.63580499
87regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.63518145
88positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.63090764
89positive regulation of interleukin-1 secretion (GO:0050716)2.62927631
90negative T cell selection (GO:0043383)2.62282731
91cellular extravasation (GO:0045123)2.61975847
92germinal center formation (GO:0002467)2.61759819
93positive regulation of interleukin-12 production (GO:0032735)2.61172355
94regulation of interleukin-8 biosynthetic process (GO:0045414)2.60981738
95regulation of T-helper 2 cell differentiation (GO:0045628)2.60789708
96NIK/NF-kappaB signaling (GO:0038061)2.59523355
97positive regulation of interleukin-2 production (GO:0032743)2.58940299
98regulation of T cell mediated cytotoxicity (GO:0001914)2.57150384
99regulation of fever generation (GO:0031620)2.57146840
100actin nucleation (GO:0045010)2.55687913
101production of molecular mediator involved in inflammatory response (GO:0002532)2.55518997
102positive regulation of interferon-beta production (GO:0032728)2.54529862
103myeloid dendritic cell differentiation (GO:0043011)2.52535249
104regulation of gamma-delta T cell activation (GO:0046643)2.51500995
105regulation of antigen processing and presentation (GO:0002577)2.50764500
106positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.50744429
107positive regulation of monocyte chemotaxis (GO:0090026)2.50258699
108myeloid dendritic cell activation (GO:0001773)2.49295424
109leukocyte degranulation (GO:0043299)2.48133224
110regulation of alpha-beta T cell proliferation (GO:0046640)2.48059571
111regulation of T cell tolerance induction (GO:0002664)2.47323206
112lymphocyte chemotaxis (GO:0048247)2.45848321
113positive T cell selection (GO:0043368)2.44789538
114positive regulation of macrophage differentiation (GO:0045651)2.42763490
115cellular response to zinc ion (GO:0071294)2.41433627
116regulation of B cell differentiation (GO:0045577)2.41414535
117negative regulation of leukocyte mediated immunity (GO:0002704)2.40353567
118positive regulation of B cell differentiation (GO:0045579)2.39893905
119positive regulation of chemokine biosynthetic process (GO:0045080)2.39522852
120positive regulation of alpha-beta T cell proliferation (GO:0046641)2.39202460
121leukocyte cell-cell adhesion (GO:0007159)2.38650519
122JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.38557357
123positive regulation of mast cell activation (GO:0033005)2.37936754
124response to type I interferon (GO:0034340)2.37820991
125cellular response to type I interferon (GO:0071357)2.37182644
126type I interferon signaling pathway (GO:0060337)2.37182644
127regulation of interleukin-17 production (GO:0032660)2.36917222
128T cell selection (GO:0045058)2.36106337
129negative regulation of lymphocyte mediated immunity (GO:0002707)2.35765916
130positive regulation of T-helper 1 type immune response (GO:0002827)2.34622455
131positive thymic T cell selection (GO:0045059)2.31826983
132regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.31735293
133T-helper 1 type immune response (GO:0042088)2.31279173
134positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.31214319
135regulation of mononuclear cell migration (GO:0071675)2.30688506
136Rap protein signal transduction (GO:0032486)2.30152747
137positive regulation of heat generation (GO:0031652)2.29860504
138detection of molecule of bacterial origin (GO:0032490)2.28532605
139I-kappaB phosphorylation (GO:0007252)2.27918285

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.88884220
2IRF8_21731497_ChIP-ChIP_J774_Mouse4.61861704
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.99267298
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.81108691
5BP1_19119308_ChIP-ChIP_Hs578T_Human3.54828319
6IRF8_27001747_Chip-Seq_BMDM_Mouse3.45861303
7* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.32599937
8SMAD_19615063_ChIP-ChIP_OVARY_Human3.21360554
9STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.11700571
10* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.85078365
11IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.81300559
12IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.73584102
13* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.70779984
14* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.64182161
15MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.60889166
16EGR1_19374776_ChIP-ChIP_THP-1_Human2.57570035
17RUNX_20019798_ChIP-Seq_JUKART_Human2.48879659
18MYB_21317192_ChIP-Seq_ERMYB_Mouse2.34064768
19IKZF1_21737484_ChIP-ChIP_HCT116_Human2.20813732
20FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.93937257
21ELF1_17652178_ChIP-ChIP_JURKAT_Human1.93921684
22* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.92674574
23VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.88185369
24SCL_19346495_ChIP-Seq_HPC-7_Human1.87339765
25TP63_17297297_ChIP-ChIP_HaCaT_Human1.80701827
26STAT4_19710469_ChIP-ChIP_TH1__Mouse1.73037928
27MYB_26560356_Chip-Seq_TH2_Human1.69542517
28VDR_24787735_ChIP-Seq_THP-1_Human1.65797208
29LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.58554668
30CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.56148187
31CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.53380738
32SPI1_23127762_ChIP-Seq_K562_Human1.49065066
33GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.47837979
34SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.44482864
35ZNF217_24962896_ChIP-Seq_MCF-7_Human1.42557034
36PU_27001747_Chip-Seq_BMDM_Mouse1.41773771
37TP53_16413492_ChIP-PET_HCT116_Human1.41706460
38CDX2_19796622_ChIP-Seq_MESCs_Mouse1.40870651
39TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.40865010
40BRD4_27068464_Chip-Seq_AML-cells_Mouse1.40536312
41NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.38274388
42RXR_22108803_ChIP-Seq_LS180_Human1.37690234
43LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.33606853
44TP53_18474530_ChIP-ChIP_U2OS_Human1.32673371
45GATA2_21666600_ChIP-Seq_HMVEC_Human1.32016819
46* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.30619183
47GATA3_27048872_Chip-Seq_THYMUS_Human1.30377897
48* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.24710606
49* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.24710606
50NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.24463405
51VDR_24763502_ChIP-Seq_THP-1_Human1.22462041
52MYB_26560356_Chip-Seq_TH1_Human1.20705916
53MAF_26560356_Chip-Seq_TH1_Human1.19527682
54STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.19178972
55* SPI1_23547873_ChIP-Seq_NB4_Human1.18567768
56PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.18485630
57GATA1_22025678_ChIP-Seq_K562_Human1.14958149
58SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.13159504
59AR_21572438_ChIP-Seq_LNCaP_Human1.09119825
60SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.08680835
61MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.08506660
62POU3F2_20337985_ChIP-ChIP_501MEL_Human1.07579858
63RUNX1_22412390_ChIP-Seq_EML_Mouse1.06205534
64* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.05285264
65NR3C1_23031785_ChIP-Seq_PC12_Mouse1.05116558
66TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.03519874
67RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.02890053
68GBX2_23144817_ChIP-Seq_PC3_Human1.02175472
69STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.01279520
70GATA2_22383799_ChIP-Seq_G1ME_Mouse1.01081383
71P300_19829295_ChIP-Seq_ESCs_Human1.00956342
72GATA3_26560356_Chip-Seq_TH2_Human1.00689247
73PRDM14_20953172_ChIP-Seq_ESCs_Human0.99437421
74SOX2_20726797_ChIP-Seq_SW620_Human0.99039107
75FLI1_27457419_Chip-Seq_LIVER_Mouse0.98855074
76FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.97197647
77BCAT_22108803_ChIP-Seq_LS180_Human0.97015002
78FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.96517286
79BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.96041359
80AR_25329375_ChIP-Seq_VCAP_Human0.94751511
81KDM2B_26808549_Chip-Seq_SUP-B15_Human0.94512270
82FOXO3_23340844_ChIP-Seq_DLD1_Human0.94508281
83ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.94468647
84GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94125458
85TCF7_22412390_ChIP-Seq_EML_Mouse0.94121593
86CJUN_26792858_Chip-Seq_BT549_Human0.93977104
87TCF4_18268006_ChIP-ChIP_LS174T_Human0.93738794
88* SMRT_27268052_Chip-Seq_Bcells_Human0.93709872
89ZFP57_27257070_Chip-Seq_ESCs_Mouse0.93070708
90EGR1_23403033_ChIP-Seq_LIVER_Mouse0.92375229
91GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.91896641
92SMAD4_21799915_ChIP-Seq_A2780_Human0.91814009
93SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91805245
94EZH2_27294783_Chip-Seq_NPCs_Mouse0.91527290
95JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.90767722
96SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.89320616
97JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.88672943
98* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.88483066
99RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.87117736
100CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.85978668
101CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.85806106
102SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.85581417
103SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.84828966
104SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.84828966
105GATA2_19941826_ChIP-Seq_K562_Human0.84213946
106EZH2_22144423_ChIP-Seq_EOC_Human0.83664469
107AHR_22903824_ChIP-Seq_MCF-7_Human0.83570104
108CRX_20693478_ChIP-Seq_RETINA_Mouse0.83063150
109ARNT_22903824_ChIP-Seq_MCF-7_Human0.82793153
110CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.82685552
111TFEB_21752829_ChIP-Seq_HELA_Human0.81879106
112* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.80965082
113* TP63_23658742_ChIP-Seq_EP156T_Human0.80734570
114GATA1_19941826_ChIP-Seq_K562_Human0.80050391
115ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.79963757
116* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.79477221
117PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.78817548
118CDX2_20551321_ChIP-Seq_CACO-2_Human0.78266920
119SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.77964963
120UTX_26944678_Chip-Seq_JUKART_Human0.77099809
121* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.76806215
122SALL4_22934838_ChIP-ChIP_CD34+_Human0.76546098
123OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.76482006
124* FOXA1_21572438_ChIP-Seq_LNCaP_Human0.76072313
125SUZ12_27294783_Chip-Seq_NPCs_Mouse0.75914524
126* KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.75758806
127CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.75633331
128TAF15_26573619_Chip-Seq_HEK293_Human0.75538303
129CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.75248937
130CDX2_22108803_ChIP-Seq_LS180_Human0.74618004
131GATA3_26560356_Chip-Seq_TH1_Human0.73428391
132CMYC_18555785_Chip-Seq_ESCs_Mouse0.73041407
133PCGF2_27294783_Chip-Seq_ESCs_Mouse0.72827832

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.73974129
2MP0003303_peritoneal_inflammation3.38706525
3MP0003436_decreased_susceptibility_to3.14886212
4MP0002148_abnormal_hypersensitivity_rea2.91503902
5MP0005000_abnormal_immune_tolerance2.89264465
6MP0009785_altered_susceptibility_to2.69114567
7MP0002419_abnormal_innate_immunity2.65757879
8MP0001790_abnormal_immune_system2.59235892
9MP0005387_immune_system_phenotype2.59235892
10MP0006082_CNS_inflammation2.57079978
11MP0005671_abnormal_response_to2.55116475
12MP0002452_abnormal_antigen_presenting2.45701770
13MP0001800_abnormal_humoral_immune2.44391494
14MP0010234_abnormal_vibrissa_follicle2.39712839
15MP0000685_abnormal_immune_system2.35231539
16MP0003300_gastrointestinal_ulcer2.34617688
17MP0005025_abnormal_response_to2.27971606
18* MP0002723_abnormal_immune_serum2.25382227
19MP0003724_increased_susceptibility_to2.22987973
20MP0004859_abnormal_synaptic_plasticity2.21086889
21MP0004510_myositis2.20804833
22* MP0001819_abnormal_immune_cell2.18537735
23* MP0002420_abnormal_adaptive_immunity2.18186377
24MP0004947_skin_inflammation2.11034477
25MP0005058_abnormal_lysosome_morphology2.02763231
26MP0005310_abnormal_salivary_gland2.01200304
27MP0000569_abnormal_digit_pigmentation1.97533657
28MP0002006_tumorigenesis1.94853223
29MP0005464_abnormal_platelet_physiology1.90700612
30MP0002166_altered_tumor_susceptibility1.85086733
31MP0003075_altered_response_to1.83166934
32MP0001533_abnormal_skeleton_physiology1.78374389
33MP0003172_abnormal_lysosome_physiology1.71249745
34MP0003183_abnormal_peptide_metabolism1.67812411
35MP0002405_respiratory_system_inflammati1.67281763
36MP0002254_reproductive_system_inflammat1.66045924
37MP0000604_amyloidosis1.61349674
38MP0010155_abnormal_intestine_physiology1.58676459
39MP0001845_abnormal_inflammatory_respons1.53687117
40* MP0002398_abnormal_bone_marrow1.52479649
41MP0005076_abnormal_cell_differentiation1.51585764
42* MP0000716_abnormal_immune_system1.50191706
43MP0003448_altered_tumor_morphology1.44888421
44MP0003763_abnormal_thymus_physiology1.42908828
45MP0001853_heart_inflammation1.41797836
46MP0005166_decreased_susceptibility_to1.39431407
47MP0002998_abnormal_bone_remodeling1.39070927
48MP0008004_abnormal_stomach_pH1.36644698
49MP0003656_abnormal_erythrocyte_physiolo1.34944709
50MP0003880_abnormal_central_pattern1.34578459
51MP0000858_altered_metastatic_potential1.33176209
52MP0005174_abnormal_tail_pigmentation1.30962981
53MP0009764_decreased_sensitivity_to1.30018788
54MP0001873_stomach_inflammation1.28124951
55MP0009840_abnormal_foam_cell1.26112352
56MP0001851_eye_inflammation1.23863470
57MP0003806_abnormal_nucleotide_metabolis1.23401441
58MP0000465_gastrointestinal_hemorrhage1.23070999
59MP0001501_abnormal_sleep_pattern1.22562770
60MP0003091_abnormal_cell_migration1.21461289
61MP0000689_abnormal_spleen_morphology1.18102863
62MP0002877_abnormal_melanocyte_morpholog1.16815983
63MP0005167_abnormal_blood-brain_barrier1.16563761
64MP0005397_hematopoietic_system_phenotyp1.12390934
65MP0001545_abnormal_hematopoietic_system1.12390934
66MP0003045_fibrosis1.11930914
67MP0002722_abnormal_immune_system1.10317087
68MP0002009_preneoplasia1.10206836
69* MP0002429_abnormal_blood_cell1.09594723
70MP0009763_increased_sensitivity_to1.09262374
71MP0000343_altered_response_to1.08413677
72MP0003635_abnormal_synaptic_transmissio1.06141944
73MP0003690_abnormal_glial_cell1.04131385
74MP0009278_abnormal_bone_marrow1.03921259
75MP0002139_abnormal_hepatobiliary_system1.03856088
76MP0008469_abnormal_protein_level1.02242917
77MP0009765_abnormal_xenobiotic_induced1.01144036
78MP0005164_abnormal_response_to0.99789796
79MP0003866_abnormal_defecation0.99699185
80MP0008260_abnormal_autophagy0.99542588
81MP0009333_abnormal_splenocyte_physiolog0.99453781
82MP0002063_abnormal_learning/memory/cond0.99170823
83MP0001440_abnormal_grooming_behavior0.98248774
84MP0003453_abnormal_keratinocyte_physiol0.96354028
85MP0003191_abnormal_cellular_cholesterol0.94230491
86MP0004185_abnormal_adipocyte_glucose0.92285180
87MP0000015_abnormal_ear_pigmentation0.92257048
88MP0002332_abnormal_exercise_endurance0.91650678
89MP0005084_abnormal_gallbladder_morpholo0.90895347
90MP0009745_abnormal_behavioral_response0.89290707
91MP0003828_pulmonary_edema0.89276701
92MP0003329_amyloid_beta_deposits0.88393726
93MP0010678_abnormal_skin_adnexa0.87711538
94MP0003566_abnormal_cell_adhesion0.82649965
95MP0002933_joint_inflammation0.81278991
96MP0005075_abnormal_melanosome_morpholog0.80573315
97MP0004883_abnormal_blood_vessel0.80267024
98MP0000703_abnormal_thymus_morphology0.79625121
99MP0002138_abnormal_hepatobiliary_system0.79378416
100MP0001663_abnormal_digestive_system0.78790814
101MP0005390_skeleton_phenotype0.78431547
102MP0002277_abnormal_respiratory_mucosa0.76145130
103MP0005171_absent_coat_pigmentation0.75669954
104MP0002064_seizures0.75042536
105MP0005165_increased_susceptibility_to0.74454446
106MP0002736_abnormal_nociception_after0.72436234
107MP0000249_abnormal_blood_vessel0.72228057
108MP0006054_spinal_hemorrhage0.70919453
109MP0001191_abnormal_skin_condition0.70505128
110MP0004808_abnormal_hematopoietic_stem0.70023095
111MP0001216_abnormal_epidermal_layer0.69868812
112MP0000920_abnormal_myelination0.68696189
113MP0003795_abnormal_bone_structure0.67138711
114MP0003195_calcinosis0.67040788
115MP0010307_abnormal_tumor_latency0.66689152
116MP0008961_abnormal_basal_metabolism0.64983592
117MP0008874_decreased_physiological_sensi0.64850385
118MP0010352_gastrointestinal_tract_polyps0.59132112
119MP0001542_abnormal_bone_strength0.58806098
120MP0002796_impaired_skin_barrier0.58146771

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)5.61869977
2Recurrent abscess formation (HP:0002722)5.41518787
3Recurrent bacterial skin infections (HP:0005406)4.81502555
4Increased cerebral lipofuscin (HP:0011813)3.91220186
5Mediastinal lymphadenopathy (HP:0100721)3.69362060
6Increased neuronal autofluorescent lipopigment (HP:0002074)3.68531849
7Myositis (HP:0100614)3.68517068
8Retrobulbar optic neuritis (HP:0100654)3.65323568
9Optic neuritis (HP:0100653)3.65323568
10Abnormality of macrophages (HP:0004311)3.62973461
11Recurrent gram-negative bacterial infections (HP:0005420)3.61358641
12Orchitis (HP:0100796)3.60636363
13Disinhibition (HP:0000734)3.41409750
14Recurrent fungal infections (HP:0002841)3.35195789
15Stomatitis (HP:0010280)3.23837174
16Vacuolated lymphocytes (HP:0001922)3.16903216
17Recurrent viral infections (HP:0004429)3.08256431
18Encephalitis (HP:0002383)3.04407601
19Hematochezia (HP:0002573)2.94106620
20Gangrene (HP:0100758)2.93670951
21Recurrent skin infections (HP:0001581)2.91111507
22Autoimmune thrombocytopenia (HP:0001973)2.89194961
23Vasculitis (HP:0002633)2.87668733
24Petechiae (HP:0000967)2.82283345
25Elevated erythrocyte sedimentation rate (HP:0003565)2.80785530
26Thick nail (HP:0001805)2.78711884
27Chronic obstructive pulmonary disease (HP:0006510)2.78176277
28Obstructive lung disease (HP:0006536)2.78176277
29Keratoconjunctivitis sicca (HP:0001097)2.77818981
30Loss of speech (HP:0002371)2.77534680
31Cellulitis (HP:0100658)2.75536579
32Pustule (HP:0200039)2.74609545
33Prolonged bleeding time (HP:0003010)2.74166681
34Gingivitis (HP:0000230)2.73476288
35Dysostosis multiplex (HP:0000943)2.72264984
36Pulmonary infiltrates (HP:0002113)2.67455037
37Chronic otitis media (HP:0000389)2.66814015
38Arterial thrombosis (HP:0004420)2.62871629
39Gastrointestinal infarctions (HP:0005244)2.62705395
40Systemic lupus erythematosus (HP:0002725)2.58815570
41Abnormality of T cell number (HP:0011839)2.56693783
42Inappropriate behavior (HP:0000719)2.53963419
43Periodontitis (HP:0000704)2.53564388
44Focal motor seizures (HP:0011153)2.53321903
45Meningitis (HP:0001287)2.52698211
46Arterial tortuosity (HP:0005116)2.52507726
47Increased IgE level (HP:0003212)2.51287898
48Epistaxis (HP:0000421)2.48926238
49Keratoconjunctivitis (HP:0001096)2.48125239
50Chronic mucocutaneous candidiasis (HP:0002728)2.42672844
51Recurrent cutaneous fungal infections (HP:0011370)2.42672844
52Abnormality of the prostate (HP:0008775)2.42168047
53Abnormality of glycolipid metabolism (HP:0010969)2.40199417
54Abnormality of liposaccharide metabolism (HP:0010968)2.40199417
55Abnormality of glycosphingolipid metabolism (HP:0004343)2.40199417
56Abnormality of B cell number (HP:0010975)2.37912801
57Absent frontal sinuses (HP:0002688)2.37604147
58Polyneuropathy (HP:0001271)2.36623276
59T lymphocytopenia (HP:0005403)2.36164486
60Purpura (HP:0000979)2.35450517
61Gingival bleeding (HP:0000225)2.35243981
62Joint swelling (HP:0001386)2.35098468
63Agammaglobulinemia (HP:0004432)2.32930861
64Recurrent bronchitis (HP:0002837)2.32022099
65IgG deficiency (HP:0004315)2.28793789
66Pulmonary embolism (HP:0002204)2.27996845
67Vascular tortuosity (HP:0004948)2.27061092
68Osteomyelitis (HP:0002754)2.26557915
69Chest pain (HP:0100749)2.25612518
70Chronic diarrhea (HP:0002028)2.25462911
71Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.25248589
72Colitis (HP:0002583)2.24254965
73Diminished motivation (HP:0000745)2.22437832
74Apathy (HP:0000741)2.22026879
75Increased IgM level (HP:0003496)2.19803281
76Abnormal delayed hypersensitivity skin test (HP:0002963)2.19526122
77Interstitial pulmonary disease (HP:0006530)2.19033101
78Autoimmune hemolytic anemia (HP:0001890)2.18994686
79Agnosia (HP:0010524)2.17510163
80Anorexia (HP:0002039)2.16788493
81Abnormality of binocular vision (HP:0011514)2.14274854
82Diplopia (HP:0000651)2.14274854
83B lymphocytopenia (HP:0010976)2.13898170
84Abnormality of the pleura (HP:0002103)2.12818804
85Premature loss of primary teeth (HP:0006323)2.12476601
86Alveolar cell carcinoma (HP:0006519)2.12291095
87Inflammation of the large intestine (HP:0002037)2.10321927
88Eosinophilia (HP:0001880)2.09220627
89Abnormality of eosinophils (HP:0001879)2.09124096
90Increased CSF protein (HP:0002922)2.08720816
91Stomach cancer (HP:0012126)2.08644971
92Thyroiditis (HP:0100646)2.08586051
93Hepatosplenomegaly (HP:0001433)2.07974190
94Spondylolisthesis (HP:0003302)2.07671320
95Leukocytosis (HP:0001974)2.07662387
96Severe combined immunodeficiency (HP:0004430)2.07508031
97Urinary glycosaminoglycan excretion (HP:0003541)2.06339191
98Mucopolysacchariduria (HP:0008155)2.06339191
99Abnormality of the vasculature of the conjunctiva (HP:0008054)2.05026825
100Parakeratosis (HP:0001036)2.04489939
101Spontaneous hematomas (HP:0007420)2.04440582
102Neoplasm of the tracheobronchial system (HP:0100552)2.04365261
103Gastrointestinal stroma tumor (HP:0100723)2.04299188
104Panhypogammaglobulinemia (HP:0003139)2.03539470
105Cerebral inclusion bodies (HP:0100314)2.01652048
106Granulocytopenia (HP:0001913)2.01646150
107Mutism (HP:0002300)2.01472102
108Hypergammaglobulinemia (HP:0010702)2.01311723
109Myocardial infarction (HP:0001658)2.01168515
110Osteolytic defects of the hand bones (HP:0009699)2.00893127
111Osteolytic defects of the phalanges of the hand (HP:0009771)2.00893127
112Axonal loss (HP:0003447)1.99722331
113Prostate neoplasm (HP:0100787)1.98990645
114Papilledema (HP:0001085)1.98194067
115Sepsis (HP:0100806)1.98147759
116Urticaria (HP:0001025)1.95560387
117Abnormality of polysaccharide metabolism (HP:0011012)1.95208623
118Abnormality of glycosaminoglycan metabolism (HP:0004371)1.95208623
119Abnormality of mucopolysaccharide metabolism (HP:0011020)1.95208623
120Gastrointestinal inflammation (HP:0004386)1.93741309
121Abnormality of T cells (HP:0002843)1.93305758
122Fatigue (HP:0012378)1.93067186
123Erythema (HP:0010783)1.92968787
124Neurofibrillary tangles (HP:0002185)1.92908194
125Visual hallucinations (HP:0002367)1.90952403
126Combined immunodeficiency (HP:0005387)1.90784970
127Hemoptysis (HP:0002105)1.90473169
128Glomerulonephritis (HP:0000099)1.90218703
129Amaurosis fugax (HP:0100576)1.88573646
130Abnormality of cells of the lymphoid lineage (HP:0012140)1.88389662
131Lymphopenia (HP:0001888)1.88359590
132Glomerulopathy (HP:0100820)1.87130803
133Episodic fever (HP:0001954)1.85458118
134Vertigo (HP:0002321)1.85453838
135Recurrent pneumonia (HP:0006532)1.84353909
136Basal ganglia calcification (HP:0002135)1.83298924

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK45.56069673
2MAP3K143.22337049
3MAP3K133.03822644
4MAP3K122.56277923
5BLK2.45980755
6TBK12.35900044
7TXK2.22420881
8IRAK42.21419772
9MAP4K12.15464526
10TYK22.07465999
11BMPR22.00355979
12EPHA41.99480066
13SIK31.97435712
14IKBKE1.97069854
15JAK31.84558173
16FES1.79542710
17STK101.78744920
18ACVR1B1.78289367
19SIK21.77227261
20TGFBR21.75372405
21IRAK31.75162779
22MAP3K91.74276076
23EIF2AK31.70960944
24PLK21.68570870
25SYK1.62851323
26JAK11.57708492
27MST41.57674108
28STK241.54970510
29GRK61.46795598
30FGR1.46033305
31KIT1.36076312
32IRAK11.34704707
33ZAP701.32265435
34HCK1.30114576
35NTRK31.29975200
36KSR21.29894552
37IKBKB1.29668105
38MAP3K31.28298991
39ITK1.27165249
40CSK1.26161988
41ADRBK21.19821926
42FGFR31.17886765
43LCK1.08079476
44MAP3K21.07524781
45IRAK21.06914070
46MAP4K21.06362542
47CLK11.06171705
48PRKCQ1.03634051
49LYN0.98187767
50MAP2K30.97075217
51NEK90.96302177
52TNK20.93323508
53TEC0.92479048
54RAF10.92180136
55DAPK10.90424251
56TAOK20.89762871
57KSR10.89521227
58CHUK0.87939047
59MARK30.87684385
60ARAF0.86751691
61PIK3CG0.86617145
62LRRK20.86352233
63FRK0.84056284
64JAK20.83733862
65MOS0.82688265
66DAPK20.81955868
67PTK2B0.80936779
68TAOK10.79126245
69PRPF4B0.77714376
70MAPKAPK30.77201206
71MST1R0.76159177
72PINK10.72933021
73CSF1R0.72259624
74GRK70.70744269
75ERBB30.70406951
76TAOK30.69114163
77BTK0.68738074
78MATK0.67455242
79GRK50.67168096
80EGFR0.64735891
81MAP3K10.64531712
82MAP2K60.63605608
83TESK20.63251416
84RIPK10.62388367
85FYN0.62100594
86MAPK70.62020637
87PDK10.57211287
88NUAK10.56790500
89CAMKK10.56674962
90ERN10.56226657
91TRIM280.55757582
92BCR0.53810975
93CDK60.53207373
94MAP3K50.51780809
95NLK0.51287212
96TRPM70.50842675
97DDR20.50545959
98TNIK0.49140752
99CDK90.48987624
100EPHA30.48152489
101PRKCD0.47929050
102PRKCH0.47835979
103PDGFRB0.47325418
104PIM10.46073257
105CAMKK20.45552711
106RET0.45045250
107CDK50.43385475
108EPHB10.42888948
109* ABL10.42502979
110IGF1R0.42355412
111OXSR10.41616041
112FER0.41219696
113EIF2AK20.38990318
114PIM20.38976073
115YES10.38955181
116PTK60.38645262
117RPS6KA40.38419773
118SGK30.38329562
119DMPK0.37391216
120PRKCE0.36656814
121SCYL20.36503877
122BMX0.36135295
123SGK10.35063859
124NTRK20.34378355
125MAP3K110.34361570
126BMPR1B0.34253010
127SGK20.34109113
128INSR0.34053701
129MAP2K70.33976244
130FGFR40.33789824
131STK30.32320536
132TESK10.30863705
133MAPKAPK20.30116372
134TGFBR10.29931275

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051402.35279822
2Osteoclast differentiation_Homo sapiens_hsa043802.14214057
3Graft-versus-host disease_Homo sapiens_hsa053321.87640532
4B cell receptor signaling pathway_Homo sapiens_hsa046621.79535074
5Toll-like receptor signaling pathway_Homo sapiens_hsa046201.78456010
6Tuberculosis_Homo sapiens_hsa051521.77248088
7NF-kappa B signaling pathway_Homo sapiens_hsa040641.76873149
8Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.73685951
9Pertussis_Homo sapiens_hsa051331.62170095
10NOD-like receptor signaling pathway_Homo sapiens_hsa046211.57706794
11Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.52102687
12Rheumatoid arthritis_Homo sapiens_hsa053231.51121986
13Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.49049806
14Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.46959636
15Salmonella infection_Homo sapiens_hsa051321.46066941
16Staphylococcus aureus infection_Homo sapiens_hsa051501.42442039
17TNF signaling pathway_Homo sapiens_hsa046681.42303196
18Allograft rejection_Homo sapiens_hsa053301.41299624
19Measles_Homo sapiens_hsa051621.41090307
20Primary immunodeficiency_Homo sapiens_hsa053401.40864561
21T cell receptor signaling pathway_Homo sapiens_hsa046601.40149465
22Long-term potentiation_Homo sapiens_hsa047201.39418313
23African trypanosomiasis_Homo sapiens_hsa051431.37663128
24Chemokine signaling pathway_Homo sapiens_hsa040621.37596663
25Type I diabetes mellitus_Homo sapiens_hsa049401.37160960
26Shigellosis_Homo sapiens_hsa051311.35331739
27Legionellosis_Homo sapiens_hsa051341.32799961
28Toxoplasmosis_Homo sapiens_hsa051451.32370737
29Malaria_Homo sapiens_hsa051441.32016168
30Intestinal immune network for IgA production_Homo sapiens_hsa046721.26668844
31Hematopoietic cell lineage_Homo sapiens_hsa046401.23227658
32Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.23195089
33Phagosome_Homo sapiens_hsa041451.20153440
34Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.19657238
35Influenza A_Homo sapiens_hsa051641.17906393
36Lysosome_Homo sapiens_hsa041421.14280661
37Antigen processing and presentation_Homo sapiens_hsa046121.13503716
38RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.12695654
39SNARE interactions in vesicular transport_Homo sapiens_hsa041301.08884654
40Hepatitis B_Homo sapiens_hsa051611.06804841
41AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.05244431
42Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.02836360
43Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.02455527
44Leukocyte transendothelial migration_Homo sapiens_hsa046701.00024692
45VEGF signaling pathway_Homo sapiens_hsa043700.98977190
46Olfactory transduction_Homo sapiens_hsa047400.96678253
47Pancreatic cancer_Homo sapiens_hsa052120.96587666
48Neurotrophin signaling pathway_Homo sapiens_hsa047220.96113383
49Platelet activation_Homo sapiens_hsa046110.95744734
50Nicotine addiction_Homo sapiens_hsa050330.95653295
51Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.94917232
52Phosphatidylinositol signaling system_Homo sapiens_hsa040700.94444618
53Salivary secretion_Homo sapiens_hsa049700.93726764
54Apoptosis_Homo sapiens_hsa042100.90027393
55Renin secretion_Homo sapiens_hsa049240.89696793
56Jak-STAT signaling pathway_Homo sapiens_hsa046300.89476005
57Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.88741211
58Collecting duct acid secretion_Homo sapiens_hsa049660.88077225
59Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.86377608
60Sphingolipid signaling pathway_Homo sapiens_hsa040710.86014739
61Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.84496479
62Glioma_Homo sapiens_hsa052140.83917421
63Amphetamine addiction_Homo sapiens_hsa050310.83353108
64Long-term depression_Homo sapiens_hsa047300.81216690
65Amoebiasis_Homo sapiens_hsa051460.80926757
66Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.80732430
67Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.80502684
68Hepatitis C_Homo sapiens_hsa051600.79708882
69Gastric acid secretion_Homo sapiens_hsa049710.79665553
70Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.79604458
71Synaptic vesicle cycle_Homo sapiens_hsa047210.79380639
72Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.79205623
73Morphine addiction_Homo sapiens_hsa050320.78528620
74Herpes simplex infection_Homo sapiens_hsa051680.78517083
75Viral myocarditis_Homo sapiens_hsa054160.77759397
76Asthma_Homo sapiens_hsa053100.77484170
77Chronic myeloid leukemia_Homo sapiens_hsa052200.77262059
78GnRH signaling pathway_Homo sapiens_hsa049120.75479020
79Dorso-ventral axis formation_Homo sapiens_hsa043200.74894743
80Glutamatergic synapse_Homo sapiens_hsa047240.73307345
81Circadian entrainment_Homo sapiens_hsa047130.72907986
82Dopaminergic synapse_Homo sapiens_hsa047280.71673693
83Prolactin signaling pathway_Homo sapiens_hsa049170.70770286
84Endocytosis_Homo sapiens_hsa041440.69527828
85Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.68876998
86Glycosaminoglycan degradation_Homo sapiens_hsa005310.68607866
87Oxytocin signaling pathway_Homo sapiens_hsa049210.67817992
88Regulation of actin cytoskeleton_Homo sapiens_hsa048100.65863303
89Autoimmune thyroid disease_Homo sapiens_hsa053200.64142904
90Cholinergic synapse_Homo sapiens_hsa047250.64102881
91Acute myeloid leukemia_Homo sapiens_hsa052210.63773472
92cAMP signaling pathway_Homo sapiens_hsa040240.63655368
93Sphingolipid metabolism_Homo sapiens_hsa006000.63651845
94Other glycan degradation_Homo sapiens_hsa005110.62319896
95Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.62200177
96MAPK signaling pathway_Homo sapiens_hsa040100.61809994
97Serotonergic synapse_Homo sapiens_hsa047260.61014693
98Adherens junction_Homo sapiens_hsa045200.59955114
99Calcium signaling pathway_Homo sapiens_hsa040200.58299202
100Proteoglycans in cancer_Homo sapiens_hsa052050.58149429
101Epstein-Barr virus infection_Homo sapiens_hsa051690.58090537
102Inositol phosphate metabolism_Homo sapiens_hsa005620.57911690
103Estrogen signaling pathway_Homo sapiens_hsa049150.57530167
104Rap1 signaling pathway_Homo sapiens_hsa040150.57529180
105Transcriptional misregulation in cancer_Homo sapiens_hsa052020.54108721
106Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.42496371
107Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.41377859
108Regulation of autophagy_Homo sapiens_hsa041400.38525206
109Systemic lupus erythematosus_Homo sapiens_hsa053220.34448594
110Sulfur metabolism_Homo sapiens_hsa009200.33680370
111Arachidonic acid metabolism_Homo sapiens_hsa005900.32590667
112Viral carcinogenesis_Homo sapiens_hsa052030.31340427
113Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.30161604
114Ether lipid metabolism_Homo sapiens_hsa005650.29128408
115HTLV-I infection_Homo sapiens_hsa051660.27884416
116Adipocytokine signaling pathway_Homo sapiens_hsa049200.25124206
117Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.22862688
118alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.22262950
119FoxO signaling pathway_Homo sapiens_hsa040680.21421545
120Mineral absorption_Homo sapiens_hsa049780.20046568
121Renal cell carcinoma_Homo sapiens_hsa052110.17873557
122HIF-1 signaling pathway_Homo sapiens_hsa040660.17554561
123Circadian rhythm_Homo sapiens_hsa047100.15306214
124Primary bile acid biosynthesis_Homo sapiens_hsa001200.14537198
125Peroxisome_Homo sapiens_hsa041460.14307981
126Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.12796483
127Non-small cell lung cancer_Homo sapiens_hsa052230.12115469
128Vibrio cholerae infection_Homo sapiens_hsa051100.12080637
129Pancreatic secretion_Homo sapiens_hsa049720.11579079
130Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.10046630

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