

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | neuron cell-cell adhesion (GO:0007158) | 5.40127169 |
| 2 | vocalization behavior (GO:0071625) | 5.19327242 |
| 3 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act | 5.14304884 |
| 4 | presynaptic membrane assembly (GO:0097105) | 5.02535741 |
| 5 | protein localization to synapse (GO:0035418) | 5.00431708 |
| 6 | positive regulation of excitatory postsynaptic membrane potential (GO:2000463) | 5.00300866 |
| 7 | regulation of short-term neuronal synaptic plasticity (GO:0048172) | 5.00232023 |
| 8 | synaptic vesicle exocytosis (GO:0016079) | 4.81103206 |
| 9 | pyrimidine nucleobase catabolic process (GO:0006208) | 4.74824819 |
| 10 | presynaptic membrane organization (GO:0097090) | 4.65184808 |
| 11 | ionotropic glutamate receptor signaling pathway (GO:0035235) | 4.62636065 |
| 12 | regulation of glutamate receptor signaling pathway (GO:1900449) | 4.62485148 |
| 13 | regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310) | 4.57133074 |
| 14 | neurotransmitter-gated ion channel clustering (GO:0072578) | 4.55389973 |
| 15 | regulation of synaptic vesicle exocytosis (GO:2000300) | 4.46424379 |
| 16 | glutamate secretion (GO:0014047) | 4.46314514 |
| 17 | synaptic vesicle docking involved in exocytosis (GO:0016081) | 4.43467319 |
| 18 | glutamate receptor signaling pathway (GO:0007215) | 4.38181825 |
| 19 | postsynaptic membrane organization (GO:0001941) | 4.32371510 |
| 20 | neuron-neuron synaptic transmission (GO:0007270) | 4.27617885 |
| 21 | synaptic transmission, glutamatergic (GO:0035249) | 4.26184199 |
| 22 | locomotory exploration behavior (GO:0035641) | 4.13586278 |
| 23 | synaptic vesicle maturation (GO:0016188) | 4.00779363 |
| 24 | neuron recognition (GO:0008038) | 3.95854434 |
| 25 | positive regulation of calcium ion-dependent exocytosis (GO:0045956) | 3.94728473 |
| 26 | regulation of synaptic vesicle transport (GO:1902803) | 3.90771843 |
| 27 | negative regulation of synaptic transmission, GABAergic (GO:0032229) | 3.90291819 |
| 28 | neuronal action potential propagation (GO:0019227) | 3.89940730 |
| 29 | regulation of long-term neuronal synaptic plasticity (GO:0048169) | 3.89518468 |
| 30 | nucleobase catabolic process (GO:0046113) | 3.82378703 |
| 31 | gamma-aminobutyric acid signaling pathway (GO:0007214) | 3.80518039 |
| 32 | regulation of excitatory postsynaptic membrane potential (GO:0060079) | 3.80507399 |
| 33 | regulation of inhibitory postsynaptic membrane potential (GO:0060080) | 3.77669006 |
| 34 | regulation of neuronal synaptic plasticity (GO:0048168) | 3.70946879 |
| 35 | exploration behavior (GO:0035640) | 3.70424824 |
| 36 | membrane depolarization during cardiac muscle cell action potential (GO:0086012) | 3.67998097 |
| 37 | axonal fasciculation (GO:0007413) | 3.67803369 |
| 38 | long-term synaptic potentiation (GO:0060291) | 3.67396486 |
| 39 | regulation of postsynaptic membrane potential (GO:0060078) | 3.64610631 |
| 40 | negative regulation of synaptic transmission, glutamatergic (GO:0051967) | 3.60522909 |
| 41 | startle response (GO:0001964) | 3.59606208 |
| 42 | neurotransmitter secretion (GO:0007269) | 3.57132998 |
| 43 | positive regulation of synapse maturation (GO:0090129) | 3.55800606 |
| 44 | G-protein coupled glutamate receptor signaling pathway (GO:0007216) | 3.54531761 |
| 45 | regulation of synaptic transmission, glutamatergic (GO:0051966) | 3.54121699 |
| 46 | response to histamine (GO:0034776) | 3.53975331 |
| 47 | cerebral cortex radially oriented cell migration (GO:0021799) | 3.51874217 |
| 48 | cerebellar granule cell differentiation (GO:0021707) | 3.46684679 |
| 49 | behavioral defense response (GO:0002209) | 3.40150911 |
| 50 | behavioral fear response (GO:0001662) | 3.40150911 |
| 51 | mechanosensory behavior (GO:0007638) | 3.39681765 |
| 52 | positive regulation of membrane potential (GO:0045838) | 3.38793056 |
| 53 | regulation of synapse structural plasticity (GO:0051823) | 3.38345845 |
| 54 | auditory behavior (GO:0031223) | 3.36415086 |
| 55 | regulation of dendritic spine morphogenesis (GO:0061001) | 3.32155726 |
| 56 | regulation of synaptic plasticity (GO:0048167) | 3.32082370 |
| 57 | dendritic spine morphogenesis (GO:0060997) | 3.31894337 |
| 58 | positive regulation of synapse assembly (GO:0051965) | 3.30532851 |
| 59 | transmission of nerve impulse (GO:0019226) | 3.29521204 |
| 60 | synaptic vesicle endocytosis (GO:0048488) | 3.29387841 |
| 61 | positive regulation of synaptic transmission, glutamatergic (GO:0051968) | 3.28951357 |
| 62 | regulation of respiratory gaseous exchange by neurological system process (GO:0002087) | 3.28393496 |
| 63 | establishment of nucleus localization (GO:0040023) | 3.28071223 |
| 64 | long-term memory (GO:0007616) | 3.27469830 |
| 65 | negative regulation of dendrite morphogenesis (GO:0050774) | 3.26076400 |
| 66 | innervation (GO:0060384) | 3.19748619 |
| 67 | regulation of neurotransmitter secretion (GO:0046928) | 3.18618569 |
| 68 | synapse assembly (GO:0007416) | 3.18402881 |
| 69 | fear response (GO:0042596) | 3.14778222 |
| 70 | behavioral response to cocaine (GO:0048148) | 3.12178024 |
| 71 | learning (GO:0007612) | 3.11906716 |
| 72 | negative regulation of dendrite development (GO:2000171) | 3.11126200 |
| 73 | layer formation in cerebral cortex (GO:0021819) | 3.08886747 |
| 74 | central nervous system projection neuron axonogenesis (GO:0021952) | 3.07193841 |
| 75 | positive regulation of neurotransmitter secretion (GO:0001956) | 3.06327624 |
| 76 | regulation of synapse maturation (GO:0090128) | 3.06037922 |
| 77 | regulation of glutamate secretion (GO:0014048) | 3.05283142 |
| 78 | membrane depolarization (GO:0051899) | 3.04690979 |
| 79 | gamma-aminobutyric acid transport (GO:0015812) | 3.04135255 |
| 80 | positive regulation of synaptic transmission, GABAergic (GO:0032230) | 3.02479480 |
| 81 | cerebellar Purkinje cell differentiation (GO:0021702) | 3.01036936 |
| 82 | nonmotile primary cilium assembly (GO:0035058) | 3.00855366 |
| 83 | behavioral response to nicotine (GO:0035095) | 3.00275637 |
| 84 | response to auditory stimulus (GO:0010996) | 2.98647207 |
| 85 | regulation of neurotransmitter transport (GO:0051588) | 2.97296992 |
| 86 | regulation of synapse assembly (GO:0051963) | 2.96869921 |
| 87 | negative regulation of neurotransmitter transport (GO:0051589) | 2.96334261 |
| 88 | regulation of synaptic transmission, GABAergic (GO:0032228) | 2.96012890 |
| 89 | regulation of female receptivity (GO:0045924) | 2.95402988 |
| 90 | neurotransmitter transport (GO:0006836) | 2.95220454 |
| 91 | regulation of dendritic spine development (GO:0060998) | 2.92940924 |
| 92 | regulation of respiratory system process (GO:0044065) | 2.90854424 |
| 93 | proline transport (GO:0015824) | 2.90014983 |
| 94 | limb bud formation (GO:0060174) | 2.88422644 |
| 95 | cell migration in hindbrain (GO:0021535) | 2.87794826 |
| 96 | positive regulation of synaptic transmission (GO:0050806) | 2.87095864 |
| 97 | dendrite morphogenesis (GO:0048813) | 2.86412652 |
| 98 | regulation of vesicle fusion (GO:0031338) | 2.86017357 |
| 99 | striatum development (GO:0021756) | 2.85851432 |
| 100 | synaptic transmission (GO:0007268) | 2.85831335 |
| 101 | positive regulation of potassium ion transmembrane transporter activity (GO:1901018) | 2.85644772 |
| 102 | membrane hyperpolarization (GO:0060081) | 2.85070987 |
| 103 | positive regulation of neurotransmitter transport (GO:0051590) | 2.85064714 |
| 104 | cochlea development (GO:0090102) | 2.84813326 |
| 105 | positive regulation of dendritic spine morphogenesis (GO:0061003) | 2.83325170 |
| 106 | * dendrite development (GO:0016358) | 2.82559490 |
| 107 | female mating behavior (GO:0060180) | 2.82447476 |
| 108 | regulation of synaptic transmission (GO:0050804) | 2.79921399 |
| 109 | membrane depolarization during action potential (GO:0086010) | 2.79582518 |
| 110 | calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339) | 2.76620193 |
| 111 | retinal ganglion cell axon guidance (GO:0031290) | 2.68398893 |
| 112 | neuromuscular synaptic transmission (GO:0007274) | 2.66835385 |
| 113 | establishment of mitochondrion localization (GO:0051654) | 2.66749163 |
| 114 | spinal cord development (GO:0021510) | 2.66706021 |
| 115 | negative regulation of cytosolic calcium ion concentration (GO:0051481) | 2.63815967 |
| 116 | synapse organization (GO:0050808) | 2.61934491 |
| 117 | central nervous system myelination (GO:0022010) | 2.60570077 |
| 118 | axon ensheathment in central nervous system (GO:0032291) | 2.60570077 |
| 119 | central nervous system neuron axonogenesis (GO:0021955) | 2.55511768 |
| 120 | regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371) | 2.54951458 |
| 121 | short-term memory (GO:0007614) | 2.52302154 |
| 122 | cerebral cortex cell migration (GO:0021795) | 2.50700201 |
| 123 | regulation of axon guidance (GO:1902667) | 2.50247023 |
| 124 | neuronal stem cell maintenance (GO:0097150) | 2.50075562 |
| 125 | neuronal ion channel clustering (GO:0045161) | 2.46828665 |
| 126 | C4-dicarboxylate transport (GO:0015740) | 2.42949103 |
| 127 | limb development (GO:0060173) | 2.40496627 |
| 128 | appendage development (GO:0048736) | 2.40496627 |
| 129 | adult walking behavior (GO:0007628) | 2.38420133 |
| 130 | hippocampus development (GO:0021766) | 2.35637544 |
| 131 | neuron migration (GO:0001764) | 2.35382429 |
| 132 | apical protein localization (GO:0045176) | 2.34777321 |
| 133 | positive regulation of dendritic spine development (GO:0060999) | 2.34484331 |
| 134 | negative regulation of axon guidance (GO:1902668) | 2.34227506 |
| 135 | myelination in peripheral nervous system (GO:0022011) | 2.33967930 |
| 136 | peripheral nervous system axon ensheathment (GO:0032292) | 2.33967930 |
| 137 | atrial cardiac muscle cell action potential (GO:0086014) | 2.33906846 |
| 138 | substrate-independent telencephalic tangential migration (GO:0021826) | 2.32826413 |
| 139 | substrate-independent telencephalic tangential interneuron migration (GO:0021843) | 2.32826413 |
| 140 | hindbrain development (GO:0030902) | 2.32506225 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EZH2_22144423_ChIP-Seq_EOC_Human | 5.27146130 |
| 2 | GBX2_23144817_ChIP-Seq_PC3_Human | 4.48812122 |
| 3 | SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 2.92932525 |
| 4 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 2.84238854 |
| 5 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 2.81503469 |
| 6 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 2.48701540 |
| 7 | SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 2.46199786 |
| 8 | TAF15_26573619_Chip-Seq_HEK293_Human | 2.44487015 |
| 9 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 2.37903596 |
| 10 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 2.37903596 |
| 11 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 2.36615985 |
| 12 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 2.35152569 |
| 13 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 2.31658537 |
| 14 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 2.31076191 |
| 15 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 2.30948145 |
| 16 | REST_21632747_ChIP-Seq_MESCs_Mouse | 2.29259673 |
| 17 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 2.25998843 |
| 18 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 2.25427786 |
| 19 | MTF2_20144788_ChIP-Seq_MESCs_Mouse | 2.10479988 |
| 20 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 2.07080704 |
| 21 | SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 2.06700109 |
| 22 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 2.04344118 |
| 23 | RNF2_27304074_Chip-Seq_ESCs_Mouse | 1.98770652 |
| 24 | P300_19829295_ChIP-Seq_ESCs_Human | 1.96569349 |
| 25 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.96355068 |
| 26 | * RARB_27405468_Chip-Seq_BRAIN_Mouse | 1.96315058 |
| 27 | AR_21572438_ChIP-Seq_LNCaP_Human | 1.94986801 |
| 28 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 1.94395347 |
| 29 | SMAD4_21799915_ChIP-Seq_A2780_Human | 1.92230130 |
| 30 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.91625041 |
| 31 | EZH2_27294783_Chip-Seq_ESCs_Mouse | 1.90374771 |
| 32 | FUS_26573619_Chip-Seq_HEK293_Human | 1.87871540 |
| 33 | SUZ12_27294783_Chip-Seq_ESCs_Mouse | 1.86547850 |
| 34 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.86464319 |
| 35 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 1.84859265 |
| 36 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.82234584 |
| 37 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.77488938 |
| 38 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.76683041 |
| 39 | REST_18959480_ChIP-ChIP_MESCs_Mouse | 1.74423881 |
| 40 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 1.73969320 |
| 41 | DROSHA_22980978_ChIP-Seq_HELA_Human | 1.73492911 |
| 42 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 1.69979685 |
| 43 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.69607024 |
| 44 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 1.66310443 |
| 45 | OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.64800293 |
| 46 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 1.63712979 |
| 47 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.62691349 |
| 48 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.60944536 |
| 49 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 1.59369956 |
| 50 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 1.58888169 |
| 51 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.58395260 |
| 52 | RNF2_16625203_ChIP-ChIP_MESCs_Mouse | 1.55779436 |
| 53 | RNF2_27304074_Chip-Seq_NSC_Mouse | 1.55589558 |
| 54 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 1.55296066 |
| 55 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 1.50273123 |
| 56 | VDR_22108803_ChIP-Seq_LS180_Human | 1.48475093 |
| 57 | STAT3_23295773_ChIP-Seq_U87_Human | 1.45470121 |
| 58 | AR_25329375_ChIP-Seq_VCAP_Human | 1.41677087 |
| 59 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.41353291 |
| 60 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.38831891 |
| 61 | * RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.35489308 |
| 62 | * SOX2_21211035_ChIP-Seq_LN229_Gbm | 1.35470170 |
| 63 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 1.34496605 |
| 64 | TCF4_23295773_ChIP-Seq_U87_Human | 1.32336700 |
| 65 | RCOR2_21632747_ChIP-Seq_MESCs_Mouse | 1.31114183 |
| 66 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.30993427 |
| 67 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.29905755 |
| 68 | ARNT_22903824_ChIP-Seq_MCF-7_Human | 1.29594779 |
| 69 | NR3C1_23031785_ChIP-Seq_PC12_Mouse | 1.27467814 |
| 70 | * TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse | 1.27077438 |
| 71 | TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human | 1.26593862 |
| 72 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 1.25548273 |
| 73 | KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse | 1.25163220 |
| 74 | EWS_26573619_Chip-Seq_HEK293_Human | 1.24083062 |
| 75 | * NANOG_18555785_Chip-Seq_ESCs_Mouse | 1.23339372 |
| 76 | RUNX2_22187159_ChIP-Seq_PCA_Human | 1.21015879 |
| 77 | * PRDM14_20953172_ChIP-Seq_ESCs_Human | 1.18239408 |
| 78 | ZNF217_24962896_ChIP-Seq_MCF-7_Human | 1.17215927 |
| 79 | STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse | 1.17140336 |
| 80 | JUN_21703547_ChIP-Seq_K562_Human | 1.17043420 |
| 81 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 1.16179886 |
| 82 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.16179886 |
| 83 | AHR_22903824_ChIP-Seq_MCF-7_Human | 1.16103608 |
| 84 | P53_22127205_ChIP-Seq_FIBROBLAST_Human | 1.14906988 |
| 85 | CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.14207799 |
| 86 | YAP1_20516196_ChIP-Seq_MESCs_Mouse | 1.13878071 |
| 87 | LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.13755757 |
| 88 | TP53_18474530_ChIP-ChIP_U2OS_Human | 1.13467509 |
| 89 | * E2F1_18555785_Chip-Seq_ESCs_Mouse | 1.12204545 |
| 90 | AR_19668381_ChIP-Seq_PC3_Human | 1.11926795 |
| 91 | NR3C1_21868756_ChIP-Seq_MCF10A_Human | 1.11730680 |
| 92 | TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.10230297 |
| 93 | MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 1.09887081 |
| 94 | CBP_20019798_ChIP-Seq_JUKART_Human | 1.09246374 |
| 95 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 1.09246374 |
| 96 | SOX9_26525672_Chip-Seq_HEART_Mouse | 1.08620327 |
| 97 | * EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse | 1.07437173 |
| 98 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 1.06681040 |
| 99 | * RING1B_27294783_Chip-Seq_ESCs_Mouse | 1.05996524 |
| 100 | TP53_16413492_ChIP-PET_HCT116_Human | 1.05482006 |
| 101 | GATA1_26923725_Chip-Seq_HPCs_Mouse | 1.03886473 |
| 102 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 1.03768244 |
| 103 | MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse | 1.03505874 |
| 104 | * P53_22387025_ChIP-Seq_ESCs_Mouse | 1.03344022 |
| 105 | * RING1B_27294783_Chip-Seq_NPCs_Mouse | 1.03247536 |
| 106 | * TBX3_20139965_ChIP-Seq_MESCs_Mouse | 1.02768993 |
| 107 | * PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.02689637 |
| 108 | * FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.02078926 |
| 109 | TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse | 1.01764070 |
| 110 | * TBX3_20139965_ChIP-Seq_ESCs_Mouse | 1.01506142 |
| 111 | * CMYC_18555785_Chip-Seq_ESCs_Mouse | 1.01193243 |
| 112 | TRIM28_17542650_ChIP-ChIP_NTERA2_Human | 0.99713900 |
| 113 | * PCGF2_27294783_Chip-Seq_NPCs_Mouse | 0.98724659 |
| 114 | BCAT_22108803_ChIP-Seq_LS180_Human | 0.98567506 |
| 115 | CEBPB_26923725_Chip-Seq_MESODERM_Mouse | 0.98442911 |
| 116 | KDM2B_26808549_Chip-Seq_REH_Human | 0.96233027 |
| 117 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 0.94980606 |
| 118 | SMAD3_21741376_ChIP-Seq_ESCs_Human | 0.94538471 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0004859_abnormal_synaptic_plasticity | 5.29450008 |
| 2 | MP0003880_abnormal_central_pattern | 4.98799872 |
| 3 | MP0003635_abnormal_synaptic_transmissio | 3.73506183 |
| 4 | MP0004270_analgesia | 3.58499132 |
| 5 | MP0009745_abnormal_behavioral_response | 3.24201220 |
| 6 | * MP0002063_abnormal_learning/memory/cond | 3.18873203 |
| 7 | MP0001968_abnormal_touch/_nociception | 2.98351336 |
| 8 | MP0002064_seizures | 2.90761361 |
| 9 | MP0009046_muscle_twitch | 2.78729367 |
| 10 | MP0002572_abnormal_emotion/affect_behav | 2.75799965 |
| 11 | MP0002734_abnormal_mechanical_nocicepti | 2.58373231 |
| 12 | MP0002735_abnormal_chemical_nociception | 2.56904672 |
| 13 | MP0001486_abnormal_startle_reflex | 2.46617189 |
| 14 | MP0002272_abnormal_nervous_system | 2.44969864 |
| 15 | MP0002736_abnormal_nociception_after | 2.41972948 |
| 16 | MP0005423_abnormal_somatic_nervous | 2.36780850 |
| 17 | MP0003787_abnormal_imprinting | 2.28274622 |
| 18 | MP0002822_catalepsy | 2.26067498 |
| 19 | MP0001188_hyperpigmentation | 2.15062633 |
| 20 | * MP0000778_abnormal_nervous_system | 2.13049403 |
| 21 | MP0002067_abnormal_sensory_capabilities | 2.03025924 |
| 22 | MP0001440_abnormal_grooming_behavior | 2.01683466 |
| 23 | MP0001501_abnormal_sleep_pattern | 1.91217454 |
| 24 | MP0005646_abnormal_pituitary_gland | 1.87949884 |
| 25 | MP0002184_abnormal_innervation | 1.86853649 |
| 26 | MP0001529_abnormal_vocalization | 1.85233766 |
| 27 | MP0002733_abnormal_thermal_nociception | 1.83700915 |
| 28 | MP0006276_abnormal_autonomic_nervous | 1.83617980 |
| 29 | MP0001970_abnormal_pain_threshold | 1.81162681 |
| 30 | MP0003122_maternal_imprinting | 1.76113444 |
| 31 | MP0005386_behavior/neurological_phenoty | 1.72977047 |
| 32 | MP0004924_abnormal_behavior | 1.72977047 |
| 33 | MP0009780_abnormal_chondrocyte_physiolo | 1.69991682 |
| 34 | MP0002557_abnormal_social/conspecific_i | 1.67869891 |
| 35 | MP0000566_synostosis | 1.67124118 |
| 36 | MP0005171_absent_coat_pigmentation | 1.65442511 |
| 37 | MP0001984_abnormal_olfaction | 1.61056778 |
| 38 | MP0004811_abnormal_neuron_physiology | 1.55312914 |
| 39 | MP0008569_lethality_at_weaning | 1.52146601 |
| 40 | MP0002653_abnormal_ependyma_morphology | 1.50788861 |
| 41 | MP0001905_abnormal_dopamine_level | 1.44102110 |
| 42 | MP0000955_abnormal_spinal_cord | 1.43508434 |
| 43 | * MP0002882_abnormal_neuron_morphology | 1.40152611 |
| 44 | MP0003879_abnormal_hair_cell | 1.38617880 |
| 45 | MP0002234_abnormal_pharynx_morphology | 1.37434773 |
| 46 | MP0000049_abnormal_middle_ear | 1.36334000 |
| 47 | MP0002938_white_spotting | 1.34392297 |
| 48 | MP0003890_abnormal_embryonic-extraembry | 1.33899096 |
| 49 | MP0005645_abnormal_hypothalamus_physiol | 1.32250071 |
| 50 | MP0001293_anophthalmia | 1.31700955 |
| 51 | MP0002066_abnormal_motor_capabilities/c | 1.30830576 |
| 52 | MP0004133_heterotaxia | 1.27763548 |
| 53 | MP0004142_abnormal_muscle_tone | 1.27481269 |
| 54 | MP0003937_abnormal_limbs/digits/tail_de | 1.26790094 |
| 55 | MP0004885_abnormal_endolymph | 1.25680501 |
| 56 | MP0004858_abnormal_nervous_system | 1.24901462 |
| 57 | MP0002233_abnormal_nose_morphology | 1.21889407 |
| 58 | MP0003119_abnormal_digestive_system | 1.20048860 |
| 59 | MP0003121_genomic_imprinting | 1.14317728 |
| 60 | * MP0002152_abnormal_brain_morphology | 1.14251488 |
| 61 | MP0005409_darkened_coat_color | 1.10655615 |
| 62 | MP0000631_abnormal_neuroendocrine_gland | 1.10608738 |
| 63 | MP0001502_abnormal_circadian_rhythm | 1.10358995 |
| 64 | MP0004742_abnormal_vestibular_system | 1.09127452 |
| 65 | MP0005551_abnormal_eye_electrophysiolog | 1.07722568 |
| 66 | MP0004043_abnormal_pH_regulation | 1.07145578 |
| 67 | MP0010386_abnormal_urinary_bladder | 1.06260548 |
| 68 | MP0002909_abnormal_adrenal_gland | 1.05464484 |
| 69 | MP0002876_abnormal_thyroid_physiology | 1.03983463 |
| 70 | MP0003633_abnormal_nervous_system | 1.02892946 |
| 71 | MP0001963_abnormal_hearing_physiology | 1.01306436 |
| 72 | MP0008789_abnormal_olfactory_epithelium | 0.99450289 |
| 73 | MP0003631_nervous_system_phenotype | 0.96640571 |
| 74 | MP0003942_abnormal_urinary_system | 0.96501851 |
| 75 | MP0001177_atelectasis | 0.96294583 |
| 76 | MP0010030_abnormal_orbit_morphology | 0.96127294 |
| 77 | MP0000534_abnormal_ureter_morphology | 0.95221938 |
| 78 | MP0002249_abnormal_larynx_morphology | 0.94991695 |
| 79 | MP0004085_abnormal_heartbeat | 0.94783633 |
| 80 | MP0003755_abnormal_palate_morphology | 0.94289725 |
| 81 | MP0003283_abnormal_digestive_organ | 0.93625351 |
| 82 | MP0003329_amyloid_beta_deposits | 0.93096739 |
| 83 | MP0002752_abnormal_somatic_nervous | 0.90868206 |
| 84 | MP0005499_abnormal_olfactory_system | 0.88059984 |
| 85 | MP0005394_taste/olfaction_phenotype | 0.88059984 |
| 86 | MP0001485_abnormal_pinna_reflex | 0.87137054 |
| 87 | * MP0001286_abnormal_eye_development | 0.86492967 |
| 88 | MP0002751_abnormal_autonomic_nervous | 0.85601265 |
| 89 | MP0006292_abnormal_olfactory_placode | 0.85555333 |
| 90 | MP0002229_neurodegeneration | 0.84971172 |
| 91 | MP0005248_abnormal_Harderian_gland | 0.84941747 |
| 92 | MP0008877_abnormal_DNA_methylation | 0.83881934 |
| 93 | MP0001986_abnormal_taste_sensitivity | 0.83284228 |
| 94 | MP0004145_abnormal_muscle_electrophysio | 0.83249682 |
| 95 | * MP0002697_abnormal_eye_size | 0.83074525 |
| 96 | MP0002069_abnormal_eating/drinking_beha | 0.83011469 |
| 97 | MP0000569_abnormal_digit_pigmentation | 0.82955387 |
| 98 | MP0000647_abnormal_sebaceous_gland | 0.80876045 |
| 99 | MP0003935_abnormal_craniofacial_develop | 0.80779424 |
| 100 | MP0002837_dystrophic_cardiac_calcinosis | 0.80733650 |
| 101 | MP0005195_abnormal_posterior_eye | 0.80487320 |
| 102 | MP0003567_abnormal_fetal_cardiomyocyte | 0.80003752 |
| 103 | MP0003385_abnormal_body_wall | 0.79623547 |
| 104 | MP0005377_hearing/vestibular/ear_phenot | 0.79405637 |
| 105 | MP0003878_abnormal_ear_physiology | 0.79405637 |
| 106 | MP0000026_abnormal_inner_ear | 0.78880644 |
| 107 | MP0004484_altered_response_of | 0.78636696 |
| 108 | MP0003136_yellow_coat_color | 0.77658476 |
| 109 | MP0000751_myopathy | 0.76848534 |
| 110 | MP0003634_abnormal_glial_cell | 0.76097457 |
| 111 | MP0003861_abnormal_nervous_system | 0.75658592 |
| 112 | MP0003123_paternal_imprinting | 0.73832905 |
| 113 | MP0002102_abnormal_ear_morphology | 0.73539494 |
| 114 | MP0003632_abnormal_nervous_system | 0.72815087 |
| 115 | MP0002638_abnormal_pupillary_reflex | 0.72112623 |
| 116 | MP0004215_abnormal_myocardial_fiber | 0.69731327 |
| 117 | MP0001299_abnormal_eye_distance/ | 0.67802233 |
| 118 | MP0000015_abnormal_ear_pigmentation | 0.67420240 |
| 119 | MP0000920_abnormal_myelination | 0.67059121 |
| 120 | MP0001943_abnormal_respiration | 0.66915547 |
| 121 | MP0001664_abnormal_digestion | 0.66472126 |
| 122 | MP0006072_abnormal_retinal_apoptosis | 0.65017797 |
| 123 | MP0008872_abnormal_physiological_respon | 0.61851540 |
| 124 | MP0003938_abnormal_ear_development | 0.60482819 |
| 125 | MP0003137_abnormal_impulse_conducting | 0.59762179 |
| 126 | MP0005253_abnormal_eye_physiology | 0.57104694 |
| 127 | MP0010770_preweaning_lethality | 0.56663401 |
| 128 | MP0002082_postnatal_lethality | 0.56663401 |
| 129 | MP0005187_abnormal_penis_morphology | 0.55296124 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Focal motor seizures (HP:0011153) | 7.39452150 |
| 2 | Epileptic encephalopathy (HP:0200134) | 5.29683783 |
| 3 | Focal seizures (HP:0007359) | 4.99565239 |
| 4 | Myokymia (HP:0002411) | 4.84918705 |
| 5 | Hyperventilation (HP:0002883) | 4.81701011 |
| 6 | Atonic seizures (HP:0010819) | 4.78215839 |
| 7 | Febrile seizures (HP:0002373) | 4.46777239 |
| 8 | Broad-based gait (HP:0002136) | 3.94297006 |
| 9 | Absence seizures (HP:0002121) | 3.88778250 |
| 10 | Progressive cerebellar ataxia (HP:0002073) | 3.84838375 |
| 11 | Dialeptic seizures (HP:0011146) | 3.68280085 |
| 12 | Visual hallucinations (HP:0002367) | 3.46529349 |
| 13 | Generalized tonic-clonic seizures (HP:0002069) | 3.36705831 |
| 14 | Gaze-evoked nystagmus (HP:0000640) | 3.21674414 |
| 15 | Excessive salivation (HP:0003781) | 3.10832995 |
| 16 | Drooling (HP:0002307) | 3.10832995 |
| 17 | Amblyopia (HP:0000646) | 3.04997482 |
| 18 | Protruding tongue (HP:0010808) | 2.95534412 |
| 19 | Impaired vibration sensation in the lower limbs (HP:0002166) | 2.80728849 |
| 20 | Termporal pattern (HP:0011008) | 2.80722415 |
| 21 | Insidious onset (HP:0003587) | 2.80722415 |
| 22 | Gait imbalance (HP:0002141) | 2.80366651 |
| 23 | Abnormal hair whorl (HP:0010721) | 2.78304350 |
| 24 | Truncal ataxia (HP:0002078) | 2.75380846 |
| 25 | Poor eye contact (HP:0000817) | 2.70256319 |
| 26 | Absent speech (HP:0001344) | 2.68800002 |
| 27 | Epileptiform EEG discharges (HP:0011182) | 2.58790989 |
| 28 | Dysdiadochokinesis (HP:0002075) | 2.53870436 |
| 29 | Urinary bladder sphincter dysfunction (HP:0002839) | 2.52092008 |
| 30 | Blue irides (HP:0000635) | 2.51213355 |
| 31 | Action tremor (HP:0002345) | 2.49733387 |
| 32 | True hermaphroditism (HP:0010459) | 2.45609432 |
| 33 | Abnormality of the corticospinal tract (HP:0002492) | 2.45140764 |
| 34 | Medial flaring of the eyebrow (HP:0010747) | 2.44145033 |
| 35 | Congenital primary aphakia (HP:0007707) | 2.42770742 |
| 36 | Progressive inability to walk (HP:0002505) | 2.39247111 |
| 37 | Inability to walk (HP:0002540) | 2.38213642 |
| 38 | Scanning speech (HP:0002168) | 2.37781942 |
| 39 | Pheochromocytoma (HP:0002666) | 2.36753244 |
| 40 | Pancreatic fibrosis (HP:0100732) | 2.36336132 |
| 41 | Atrophy/Degeneration involving the corticospinal tracts (HP:0007372) | 2.35607071 |
| 42 | Degeneration of the lateral corticospinal tracts (HP:0002314) | 2.35607071 |
| 43 | Genetic anticipation (HP:0003743) | 2.33445163 |
| 44 | Abnormal eating behavior (HP:0100738) | 2.33053004 |
| 45 | Septo-optic dysplasia (HP:0100842) | 2.32143787 |
| 46 | Nephronophthisis (HP:0000090) | 2.30886232 |
| 47 | Nephrogenic diabetes insipidus (HP:0009806) | 2.29283403 |
| 48 | EEG with generalized epileptiform discharges (HP:0011198) | 2.28617402 |
| 49 | Fetal akinesia sequence (HP:0001989) | 2.28443640 |
| 50 | Dysmetria (HP:0001310) | 2.27998721 |
| 51 | Pancreatic cysts (HP:0001737) | 2.26958571 |
| 52 | Ankle clonus (HP:0011448) | 2.26824612 |
| 53 | Limb dystonia (HP:0002451) | 2.26398621 |
| 54 | Abnormality of midbrain morphology (HP:0002418) | 2.22178383 |
| 55 | Molar tooth sign on MRI (HP:0002419) | 2.22178383 |
| 56 | Abnormal social behavior (HP:0012433) | 2.20461621 |
| 57 | Impaired social interactions (HP:0000735) | 2.20461621 |
| 58 | Cutaneous finger syndactyly (HP:0010554) | 2.17949567 |
| 59 | Abnormality of salivation (HP:0100755) | 2.15147467 |
| 60 | Optic nerve hypoplasia (HP:0000609) | 2.13692072 |
| 61 | Specific learning disability (HP:0001328) | 2.13354755 |
| 62 | Depression (HP:0000716) | 2.12723961 |
| 63 | Bilateral microphthalmos (HP:0007633) | 2.11501296 |
| 64 | Impaired smooth pursuit (HP:0007772) | 2.10724357 |
| 65 | Anxiety (HP:0000739) | 2.09567779 |
| 66 | Hypsarrhythmia (HP:0002521) | 2.09435476 |
| 67 | Neuroendocrine neoplasm (HP:0100634) | 2.09236281 |
| 68 | Urinary urgency (HP:0000012) | 2.08834516 |
| 69 | Preaxial foot polydactyly (HP:0001841) | 2.08312439 |
| 70 | Polyphagia (HP:0002591) | 2.08306463 |
| 71 | Genital tract atresia (HP:0001827) | 2.07547293 |
| 72 | Stereotypic behavior (HP:0000733) | 2.06691425 |
| 73 | Diplopia (HP:0000651) | 2.04456321 |
| 74 | Abnormality of binocular vision (HP:0011514) | 2.04456321 |
| 75 | Vaginal atresia (HP:0000148) | 2.03154229 |
| 76 | Supranuclear gaze palsy (HP:0000605) | 2.03033513 |
| 77 | Intestinal atresia (HP:0011100) | 2.01430193 |
| 78 | Abnormality of the labia minora (HP:0012880) | 2.00581154 |
| 79 | Thickened helices (HP:0000391) | 1.98649335 |
| 80 | Aplasia/Hypoplasia of the optic nerve (HP:0008058) | 1.98580293 |
| 81 | Gastroesophageal reflux (HP:0002020) | 1.98384119 |
| 82 | Hemiparesis (HP:0001269) | 1.96250262 |
| 83 | Pachygyria (HP:0001302) | 1.96154097 |
| 84 | Impaired vibratory sensation (HP:0002495) | 1.95561059 |
| 85 | Colon cancer (HP:0003003) | 1.95456866 |
| 86 | Postaxial hand polydactyly (HP:0001162) | 1.91295771 |
| 87 | Abnormality of the renal medulla (HP:0100957) | 1.90951539 |
| 88 | Spastic gait (HP:0002064) | 1.90853508 |
| 89 | Anophthalmia (HP:0000528) | 1.87578495 |
| 90 | Morphological abnormality of the middle ear (HP:0008609) | 1.87560009 |
| 91 | Akinesia (HP:0002304) | 1.87245835 |
| 92 | Aplasia/Hypoplasia of the pubic bone (HP:0009104) | 1.86740579 |
| 93 | Cutaneous syndactyly (HP:0012725) | 1.86106167 |
| 94 | Abnormality of the ischium (HP:0003174) | 1.84847074 |
| 95 | Mutism (HP:0002300) | 1.83619146 |
| 96 | Generalized hypopigmentation of hair (HP:0011358) | 1.83614083 |
| 97 | Aqueductal stenosis (HP:0002410) | 1.83561906 |
| 98 | Short 4th metacarpal (HP:0010044) | 1.83559753 |
| 99 | Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042) | 1.83559753 |
| 100 | Widely spaced teeth (HP:0000687) | 1.83424410 |
| 101 | Dysmetric saccades (HP:0000641) | 1.83403012 |
| 102 | Generalized myoclonic seizures (HP:0002123) | 1.82993337 |
| 103 | Type II lissencephaly (HP:0007260) | 1.82843859 |
| 104 | Poor coordination (HP:0002370) | 1.82534275 |
| 105 | Cortical dysplasia (HP:0002539) | 1.82520724 |
| 106 | Incomplete penetrance (HP:0003829) | 1.81063370 |
| 107 | Exotropia (HP:0000577) | 1.80901013 |
| 108 | Postural instability (HP:0002172) | 1.80882683 |
| 109 | Lower limb muscle weakness (HP:0007340) | 1.79986681 |
| 110 | Retinal dysplasia (HP:0007973) | 1.77388431 |
| 111 | Fair hair (HP:0002286) | 1.77169959 |
| 112 | Absent/shortened dynein arms (HP:0200106) | 1.76037284 |
| 113 | Dynein arm defect of respiratory motile cilia (HP:0012255) | 1.76037284 |
| 114 | Heterochromia iridis (HP:0001100) | 1.75614560 |
| 115 | Oligodactyly (hands) (HP:0001180) | 1.75214236 |
| 116 | Midline defect of the nose (HP:0004122) | 1.74325488 |
| 117 | Bradykinesia (HP:0002067) | 1.73697784 |
| 118 | Aplasia/Hypoplasia of the sternum (HP:0006714) | 1.72657881 |
| 119 | Torticollis (HP:0000473) | 1.72156986 |
| 120 | Abnormality of the pubic bones (HP:0003172) | 1.71957610 |
| 121 | Inappropriate behavior (HP:0000719) | 1.71853540 |
| 122 | Abnormality of ocular smooth pursuit (HP:0000617) | 1.71768748 |
| 123 | Hyperthyroidism (HP:0000836) | 1.71126199 |
| 124 | Hypoplasia of the brainstem (HP:0002365) | 1.71042951 |
| 125 | Aplasia/Hypoplasia of the brainstem (HP:0007362) | 1.71042951 |
| 126 | Morphological abnormality of the pyramidal tract (HP:0002062) | 1.70536802 |
| 127 | Broad foot (HP:0001769) | 1.70269880 |
| 128 | Bronchomalacia (HP:0002780) | 1.69767066 |
| 129 | Cystic liver disease (HP:0006706) | 1.69578766 |
| 130 | Megalencephaly (HP:0001355) | 1.69137449 |
| 131 | Split foot (HP:0001839) | 1.69066265 |
| 132 | Hepatoblastoma (HP:0002884) | 1.66315329 |
| 133 | Spastic tetraplegia (HP:0002510) | 1.65969398 |
| 134 | Postaxial foot polydactyly (HP:0001830) | 1.65309718 |
| 135 | Lissencephaly (HP:0001339) | 1.65197691 |
| 136 | Neoplasm of the oral cavity (HP:0100649) | 1.64837790 |
| 137 | Sleep apnea (HP:0010535) | 1.64686653 |
| 138 | Cerebellar dysplasia (HP:0007033) | 1.64204203 |
| 139 | Hypoplastic ischia (HP:0003175) | 1.63815284 |
| 140 | Micropenis (HP:0000054) | 1.62600146 |
| 141 | Bifid tongue (HP:0010297) | 1.62365368 |
| 142 | Focal dystonia (HP:0004373) | 1.62004634 |
| 143 | Gastrointestinal atresia (HP:0002589) | 1.61730549 |
| 144 | Short foot (HP:0001773) | 1.61207694 |
| 145 | Abnormality of the lower motor neuron (HP:0002366) | 1.60405697 |
| 146 | Abnormality of the diencephalon (HP:0010662) | 1.59664368 |
| 147 | Absent eyebrow (HP:0002223) | 1.59558375 |
| 148 | Abnormality of the 4th metacarpal (HP:0010012) | 1.57347061 |
| 149 | Renal hypoplasia (HP:0000089) | 1.57304572 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | CASK | 5.23851870 |
| 2 | NTRK3 | 3.95277101 |
| 3 | EPHA4 | 3.89302132 |
| 4 | MARK1 | 3.18504814 |
| 5 | MAP3K4 | 2.92317416 |
| 6 | MAP2K7 | 2.86262005 |
| 7 | PLK2 | 2.32522169 |
| 8 | MINK1 | 2.30576353 |
| 9 | PRPF4B | 2.16985986 |
| 10 | DAPK2 | 2.10359326 |
| 11 | MAP3K12 | 2.09328255 |
| 12 | AKT3 | 2.05134510 |
| 13 | MAP3K9 | 2.01096334 |
| 14 | MAPK13 | 1.86953204 |
| 15 | KSR1 | 1.76819647 |
| 16 | CDK19 | 1.70597996 |
| 17 | NTRK2 | 1.68415266 |
| 18 | FRK | 1.65317690 |
| 19 | RIPK4 | 1.64693295 |
| 20 | DAPK1 | 1.61560042 |
| 21 | SIK3 | 1.59418466 |
| 22 | MAP2K4 | 1.51610552 |
| 23 | TNIK | 1.50631191 |
| 24 | PINK1 | 1.45602010 |
| 25 | BMPR2 | 1.45061047 |
| 26 | SGK2 | 1.41170141 |
| 27 | OXSR1 | 1.38761211 |
| 28 | PAK6 | 1.35697015 |
| 29 | SGK223 | 1.35421771 |
| 30 | SGK494 | 1.35421771 |
| 31 | BCR | 1.33633178 |
| 32 | CCNB1 | 1.30865015 |
| 33 | CDK5 | 1.25156345 |
| 34 | PNCK | 1.20199831 |
| 35 | MKNK1 | 1.16226094 |
| 36 | PRKCG | 1.15707019 |
| 37 | LATS1 | 1.14124146 |
| 38 | ERBB3 | 1.12910570 |
| 39 | GRK5 | 1.10681850 |
| 40 | CAMK2A | 1.09753410 |
| 41 | EPHA3 | 1.09015346 |
| 42 | TRIM28 | 1.08628607 |
| 43 | CSNK1G1 | 1.07728267 |
| 44 | EPHB2 | 1.05574368 |
| 45 | CSNK1G3 | 1.03782404 |
| 46 | PRKD3 | 0.99620578 |
| 47 | CAMK2B | 0.99361483 |
| 48 | CSNK1A1L | 0.98104221 |
| 49 | CAMK1G | 0.98000091 |
| 50 | KSR2 | 0.97497618 |
| 51 | NTRK1 | 0.97414239 |
| 52 | STK38L | 0.93394008 |
| 53 | UHMK1 | 0.87962703 |
| 54 | SGK3 | 0.86492037 |
| 55 | CAMKK1 | 0.86237691 |
| 56 | CDK18 | 0.85775925 |
| 57 | ARAF | 0.84584650 |
| 58 | CAMKK2 | 0.84320559 |
| 59 | MAPK15 | 0.83526540 |
| 60 | NUAK1 | 0.81996804 |
| 61 | CDK14 | 0.79622743 |
| 62 | WNK4 | 0.78177936 |
| 63 | PTK2B | 0.78136471 |
| 64 | PRKCE | 0.77536277 |
| 65 | SGK1 | 0.76437701 |
| 66 | DYRK1A | 0.75580103 |
| 67 | CDK15 | 0.74748274 |
| 68 | NEK2 | 0.74307763 |
| 69 | SIK2 | 0.73438295 |
| 70 | WNK3 | 0.72681773 |
| 71 | FES | 0.71198014 |
| 72 | CSNK1G2 | 0.69777069 |
| 73 | MAP4K2 | 0.68213050 |
| 74 | WEE1 | 0.66959368 |
| 75 | NEK6 | 0.65983784 |
| 76 | BMPR1B | 0.64210370 |
| 77 | BRAF | 0.63657785 |
| 78 | BRD4 | 0.62433106 |
| 79 | NME1 | 0.62093885 |
| 80 | CDK11A | 0.62042726 |
| 81 | PKN1 | 0.61887434 |
| 82 | ERBB2 | 0.61863481 |
| 83 | PHKG1 | 0.61615581 |
| 84 | PHKG2 | 0.61615581 |
| 85 | DYRK3 | 0.61191291 |
| 86 | DMPK | 0.59876618 |
| 87 | CDK3 | 0.58793630 |
| 88 | MAP3K2 | 0.58759908 |
| 89 | DYRK2 | 0.58622337 |
| 90 | INSRR | 0.57774472 |
| 91 | FGR | 0.57047285 |
| 92 | STK39 | 0.56926234 |
| 93 | CDC7 | 0.54401027 |
| 94 | PLK3 | 0.53564170 |
| 95 | ZAK | 0.52534978 |
| 96 | ADRBK2 | 0.52516234 |
| 97 | WNK1 | 0.51945777 |
| 98 | YES1 | 0.51745175 |
| 99 | MARK2 | 0.50932968 |
| 100 | STK11 | 0.50686545 |
| 101 | CAMK1D | 0.50108096 |
| 102 | CAMK1 | 0.50097100 |
| 103 | CAMK2D | 0.49939148 |
| 104 | CSNK1E | 0.49450335 |
| 105 | GRK7 | 0.49101155 |
| 106 | PRKCH | 0.48959211 |
| 107 | LATS2 | 0.48755478 |
| 108 | MKNK2 | 0.48034289 |
| 109 | CSNK1D | 0.47272211 |
| 110 | RAF1 | 0.46880684 |
| 111 | PAK3 | 0.46418542 |
| 112 | TSSK6 | 0.45423179 |
| 113 | FGFR1 | 0.42624825 |
| 114 | PRKDC | 0.42043816 |
| 115 | MAP3K6 | 0.39591185 |
| 116 | GRK1 | 0.39538916 |
| 117 | ADRBK1 | 0.39471250 |
| 118 | PLK4 | 0.39238056 |
| 119 | ACVR1B | 0.39150653 |
| 120 | MAP3K13 | 0.38864587 |
| 121 | RPS6KA4 | 0.38705961 |
| 122 | ROCK2 | 0.38530292 |
| 123 | FER | 0.37603605 |
| 124 | PRKG1 | 0.37326528 |
| 125 | RPS6KA3 | 0.36921983 |
| 126 | RPS6KA2 | 0.36718589 |
| 127 | RET | 0.35353022 |
| 128 | PRKCZ | 0.35336712 |
| 129 | MAPK10 | 0.34675277 |
| 130 | CAMK2G | 0.33621286 |
| 131 | TYRO3 | 0.32761604 |
| 132 | CAMK4 | 0.32101373 |
| 133 | PRKCB | 0.31690601 |
| 134 | PRKACA | 0.31625279 |
| 135 | FGFR2 | 0.31595547 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Nicotine addiction_Homo sapiens_hsa05033 | 4.11511864 |
| 2 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 3.13334379 |
| 3 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 2.85093139 |
| 4 | Circadian entrainment_Homo sapiens_hsa04713 | 2.74637982 |
| 5 | Long-term potentiation_Homo sapiens_hsa04720 | 2.71339938 |
| 6 | Olfactory transduction_Homo sapiens_hsa04740 | 2.68173155 |
| 7 | Morphine addiction_Homo sapiens_hsa05032 | 2.67408270 |
| 8 | GABAergic synapse_Homo sapiens_hsa04727 | 2.61624210 |
| 9 | Glutamatergic synapse_Homo sapiens_hsa04724 | 2.59410276 |
| 10 | Amphetamine addiction_Homo sapiens_hsa05031 | 2.52330000 |
| 11 | Dopaminergic synapse_Homo sapiens_hsa04728 | 2.28262083 |
| 12 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 2.07654443 |
| 13 | Taste transduction_Homo sapiens_hsa04742 | 2.05480894 |
| 14 | Serotonergic synapse_Homo sapiens_hsa04726 | 2.00877193 |
| 15 | Salivary secretion_Homo sapiens_hsa04970 | 1.99262513 |
| 16 | Long-term depression_Homo sapiens_hsa04730 | 1.89201477 |
| 17 | Renin secretion_Homo sapiens_hsa04924 | 1.85845332 |
| 18 | Insulin secretion_Homo sapiens_hsa04911 | 1.84656220 |
| 19 | Cholinergic synapse_Homo sapiens_hsa04725 | 1.81314052 |
| 20 | Cocaine addiction_Homo sapiens_hsa05030 | 1.63731865 |
| 21 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 1.61916497 |
| 22 | Calcium signaling pathway_Homo sapiens_hsa04020 | 1.60901919 |
| 23 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 1.56850755 |
| 24 | Gastric acid secretion_Homo sapiens_hsa04971 | 1.56164811 |
| 25 | Axon guidance_Homo sapiens_hsa04360 | 1.53145635 |
| 26 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 1.50206116 |
| 27 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 1.48489568 |
| 28 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 1.46381222 |
| 29 | Basal cell carcinoma_Homo sapiens_hsa05217 | 1.45336344 |
| 30 | Phototransduction_Homo sapiens_hsa04744 | 1.42768002 |
| 31 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 1.37837379 |
| 32 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.37674975 |
| 33 | Hippo signaling pathway_Homo sapiens_hsa04390 | 1.36585996 |
| 34 | Gap junction_Homo sapiens_hsa04540 | 1.35841928 |
| 35 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 1.26640194 |
| 36 | cAMP signaling pathway_Homo sapiens_hsa04024 | 1.25785316 |
| 37 | GnRH signaling pathway_Homo sapiens_hsa04912 | 1.23045852 |
| 38 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 1.21028095 |
| 39 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 1.14769434 |
| 40 | ErbB signaling pathway_Homo sapiens_hsa04012 | 1.12836866 |
| 41 | Melanogenesis_Homo sapiens_hsa04916 | 1.10928556 |
| 42 | Steroid biosynthesis_Homo sapiens_hsa00100 | 1.10587952 |
| 43 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 1.10504987 |
| 44 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 1.07668929 |
| 45 | Glioma_Homo sapiens_hsa05214 | 1.03367801 |
| 46 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 1.03355765 |
| 47 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.00356259 |
| 48 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.99195819 |
| 49 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.97484565 |
| 50 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.95918716 |
| 51 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 0.94667456 |
| 52 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.94045160 |
| 53 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.92053310 |
| 54 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.88888058 |
| 55 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.88319629 |
| 56 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.87387124 |
| 57 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.78774741 |
| 58 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.78019429 |
| 59 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 0.76660180 |
| 60 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.75964233 |
| 61 | Alcoholism_Homo sapiens_hsa05034 | 0.75886432 |
| 62 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 0.75186087 |
| 63 | Basal transcription factors_Homo sapiens_hsa03022 | 0.74706731 |
| 64 | Alzheimers disease_Homo sapiens_hsa05010 | 0.74256440 |
| 65 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.74142149 |
| 66 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.73329960 |
| 67 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.71644100 |
| 68 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.70747925 |
| 69 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.69422497 |
| 70 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.68786009 |
| 71 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.67275391 |
| 72 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.66987869 |
| 73 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.66719597 |
| 74 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.65964435 |
| 75 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.64968060 |
| 76 | Protein export_Homo sapiens_hsa03060 | 0.64729558 |
| 77 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.63862534 |
| 78 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.63293913 |
| 79 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.62910382 |
| 80 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.60888760 |
| 81 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.60822661 |
| 82 | Adherens junction_Homo sapiens_hsa04520 | 0.60518154 |
| 83 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.60344058 |
| 84 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.59208110 |
| 85 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.57680938 |
| 86 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.57252414 |
| 87 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.57153583 |
| 88 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.56099027 |
| 89 | Endometrial cancer_Homo sapiens_hsa05213 | 0.55486280 |
| 90 | RNA degradation_Homo sapiens_hsa03018 | 0.54129734 |
| 91 | Bile secretion_Homo sapiens_hsa04976 | 0.53300181 |
| 92 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.52975381 |
| 93 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.52373021 |
| 94 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.51081023 |
| 95 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.50832908 |
| 96 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 0.50202537 |
| 97 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.49847075 |
| 98 | Lysine degradation_Homo sapiens_hsa00310 | 0.48921322 |
| 99 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.48221699 |
| 100 | Parkinsons disease_Homo sapiens_hsa05012 | 0.48189007 |
| 101 | Melanoma_Homo sapiens_hsa05218 | 0.48058954 |
| 102 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.47970052 |
| 103 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.47908629 |
| 104 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.46971440 |
| 105 | Circadian rhythm_Homo sapiens_hsa04710 | 0.46517937 |
| 106 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.46464027 |
| 107 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.44530219 |
| 108 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 0.44247982 |
| 109 | Colorectal cancer_Homo sapiens_hsa05210 | 0.43907457 |
| 110 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.43358796 |
| 111 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.43043290 |
| 112 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.42717853 |
| 113 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.42572376 |
| 114 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.42227817 |
| 115 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.41195293 |
| 116 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.40511242 |
| 117 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.39824030 |
| 118 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.39732593 |
| 119 | Phagosome_Homo sapiens_hsa04145 | 0.39645347 |
| 120 | Huntingtons disease_Homo sapiens_hsa05016 | 0.39239860 |
| 121 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.38846597 |
| 122 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.37854724 |
| 123 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.35890922 |
| 124 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.35743050 |
| 125 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.35688532 |
| 126 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.34341325 |
| 127 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.33550458 |
| 128 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.30882904 |
| 129 | Tight junction_Homo sapiens_hsa04530 | 0.30105932 |
| 130 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.29660241 |
| 131 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.27739967 |

