ABL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress. The activity of the protein is negatively regulated by its SH3 domain, whereby deletion of the region encoding this domain results in an oncogene. The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function. This gene has been found fused to a variety of translocation partner genes in various leukemias, most notably the t(9;22) translocation that results in a fusion with the 5' end of the breakpoint cluster region gene (BCR; MIM:151410). Alternative splicing of this gene results in two transcript variants, which contain alternative first exons that are spliced to the remaining common exons. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Golgi transport vesicle coating (GO:0048200)3.96148361
2COPI coating of Golgi vesicle (GO:0048205)3.96148361
3focal adhesion assembly (GO:0048041)3.58386775
4cell-substrate adherens junction assembly (GO:0007045)3.58386775
5bone trabecula formation (GO:0060346)3.48635194
6maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.44187418
7protein retention in ER lumen (GO:0006621)3.43525857
8planar cell polarity pathway involved in neural tube closure (GO:0090179)3.30092291
9protein heterotrimerization (GO:0070208)3.29856335
10convergent extension (GO:0060026)3.28166697
11cortical actin cytoskeleton organization (GO:0030866)3.26621748
12regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.19902701
13positive regulation of histone deacetylation (GO:0031065)3.15957275
14regulation of early endosome to late endosome transport (GO:2000641)3.14036738
15outer ear morphogenesis (GO:0042473)3.10538321
16hippo signaling (GO:0035329)3.10183088
17regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.06138019
18mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.05724604
19semaphorin-plexin signaling pathway (GO:0071526)3.04263829
20polarized epithelial cell differentiation (GO:0030859)3.02095777
21cytoskeletal anchoring at plasma membrane (GO:0007016)2.97897885
22insulin-like growth factor receptor signaling pathway (GO:0048009)2.96757901
23nuclear pore complex assembly (GO:0051292)2.96592761
24lateral sprouting from an epithelium (GO:0060601)2.95335143
25hemidesmosome assembly (GO:0031581)2.94132373
26cytoplasmic mRNA processing body assembly (GO:0033962)2.93636770
27vascular endothelial growth factor signaling pathway (GO:0038084)2.92254926
28glomerular filtration (GO:0003094)2.88997280
29barbed-end actin filament capping (GO:0051016)2.88475016
30regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.88134253
31cell migration involved in heart development (GO:0060973)2.87229960
32cell migration involved in sprouting angiogenesis (GO:0002042)2.86620135
33DNA unwinding involved in DNA replication (GO:0006268)2.84757775
34regulation of glucose import in response to insulin stimulus (GO:2001273)2.84031421
35cortical cytoskeleton organization (GO:0030865)2.82138129
36collagen metabolic process (GO:0032963)2.81593451
37positive regulation of SMAD protein import into nucleus (GO:0060391)2.81161396
38renal filtration (GO:0097205)2.81049270
39collagen fibril organization (GO:0030199)2.79240559
40mitotic chromosome condensation (GO:0007076)2.77281950
41retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.77224432
42endothelial cell morphogenesis (GO:0001886)2.76758427
43central nervous system myelination (GO:0022010)2.76644109
44axon ensheathment in central nervous system (GO:0032291)2.76644109
45dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.75605740
46heart morphogenesis (GO:0003007)2.72624673
47endocardial cushion development (GO:0003197)2.71176322
48regulation of NFAT protein import into nucleus (GO:0051532)2.70609045
49regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.70065561
50notochord development (GO:0030903)2.68747763
51axon ensheathment (GO:0008366)2.68700953
52ensheathment of neurons (GO:0007272)2.68700953
53multicellular organismal macromolecule metabolic process (GO:0044259)2.67857749
54regulation of nucleobase-containing compound transport (GO:0032239)2.67544852
55embryonic retina morphogenesis in camera-type eye (GO:0060059)2.66750774
56protein localization to endosome (GO:0036010)2.65479138
57regulation of SMAD protein import into nucleus (GO:0060390)2.65305187
58paraxial mesoderm development (GO:0048339)2.65221192
59adherens junction assembly (GO:0034333)2.64828877
60peptidyl-proline hydroxylation (GO:0019511)2.64365609
61cell adhesion mediated by integrin (GO:0033627)2.63868192
62collagen catabolic process (GO:0030574)2.63785773
63glucocorticoid receptor signaling pathway (GO:0042921)2.63527053
64endodermal cell differentiation (GO:0035987)2.62238468
65craniofacial suture morphogenesis (GO:0097094)2.62223545
66cellular protein complex localization (GO:0034629)2.60531392
67kidney mesenchyme development (GO:0072074)2.60186951
68response to laminar fluid shear stress (GO:0034616)2.59969368
69myelin maintenance (GO:0043217)2.59500826
70germ cell migration (GO:0008354)2.58813112
71myelination (GO:0042552)2.58467575
72vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.58432098
73Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.57472980
74blood vessel endothelial cell migration (GO:0043534)2.56496690
75atrioventricular valve morphogenesis (GO:0003181)2.56153634
76negative regulation of cell size (GO:0045792)2.55024863
77cardiac myofibril assembly (GO:0055003)2.54487528
78regulation of establishment of planar polarity (GO:0090175)2.54427983
79response to fluid shear stress (GO:0034405)2.52964021
80basement membrane organization (GO:0071711)2.52873734
81endothelial cell chemotaxis (GO:0035767)2.51836696
82positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.51135726
83cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.49993593
84multicellular organismal metabolic process (GO:0044236)2.49279871
85apoptotic process involved in morphogenesis (GO:0060561)2.48565687
86anatomical structure regression (GO:0060033)2.48499299
87retina vasculature morphogenesis in camera-type eye (GO:0061299)2.47732438
88gastrulation with mouth forming second (GO:0001702)2.47062338
89extracellular matrix disassembly (GO:0022617)2.46914133
90regulation of translational fidelity (GO:0006450)2.46425701
91negative regulation of catenin import into nucleus (GO:0035414)2.46317557
92lens fiber cell development (GO:0070307)2.46274335
93stress fiber assembly (GO:0043149)2.45962148
94myelination in peripheral nervous system (GO:0022011)2.45777246
95peripheral nervous system axon ensheathment (GO:0032292)2.45777246
96vesicle coating (GO:0006901)2.44634343
97axis elongation (GO:0003401)2.44584320
98cell-substrate junction assembly (GO:0007044)2.44192304
99chondrocyte proliferation (GO:0035988)2.43909879
100mesodermal cell differentiation (GO:0048333)2.43722614
101camera-type eye morphogenesis (GO:0048593)2.43343411
102regulation of mammary gland epithelial cell proliferation (GO:0033599)2.42738520
103multicellular organismal catabolic process (GO:0044243)2.40290258
104head development (GO:0060322)2.38874375
105protein complex localization (GO:0031503)2.38758399
106activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.38676500
107establishment of epithelial cell polarity (GO:0090162)2.37711950
108negative regulation of chondrocyte differentiation (GO:0032331)2.37224292
109nuclear pore organization (GO:0006999)2.35407207
110face morphogenesis (GO:0060325)2.34566641
111positive regulation of blood vessel endothelial cell migration (GO:0043536)2.34458298
112eye morphogenesis (GO:0048592)2.34207019
113heterochromatin organization (GO:0070828)2.33976632
114positive regulation of epithelial to mesenchymal transition (GO:0010718)2.33937021
115cranial suture morphogenesis (GO:0060363)2.33646563
116regulation of RNA export from nucleus (GO:0046831)2.33627496
117RNA stabilization (GO:0043489)2.33534348
118mRNA stabilization (GO:0048255)2.33534348
119neuron projection extension involved in neuron projection guidance (GO:1902284)2.33408034
120axon extension involved in axon guidance (GO:0048846)2.33408034
121proline biosynthetic process (GO:0006561)2.32599437
122positive regulation of osteoblast proliferation (GO:0033690)2.32161595
123positive regulation of nuclease activity (GO:0032075)2.32136380
124establishment or maintenance of apical/basal cell polarity (GO:0035088)2.32109936
125establishment or maintenance of bipolar cell polarity (GO:0061245)2.32109936
126protein hydroxylation (GO:0018126)2.32057005
127pre-miRNA processing (GO:0031054)2.31851575
128positive regulation of gene expression, epigenetic (GO:0045815)2.31623436
129metanephric mesenchyme development (GO:0072075)2.31553451
130regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.30106975
131maternal placenta development (GO:0001893)2.30026276
132establishment of mitotic spindle orientation (GO:0000132)2.29285770
133extracellular fibril organization (GO:0043206)2.28805432
134embryonic eye morphogenesis (GO:0048048)2.28782996
135pathway-restricted SMAD protein phosphorylation (GO:0060389)2.28153383
136protein-DNA complex disassembly (GO:0032986)2.27902757
137nucleosome disassembly (GO:0006337)2.27902757
138non-canonical Wnt signaling pathway (GO:0035567)2.27821683
139establishment of apical/basal cell polarity (GO:0035089)2.27817114
140cochlea morphogenesis (GO:0090103)2.27790425
141apoptotic cell clearance (GO:0043277)2.27372498
142somatic stem cell division (GO:0048103)2.26705492
143neural tube development (GO:0021915)2.26367559
144establishment of mitotic spindle localization (GO:0040001)2.25760070
145regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.25758682
146establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.25579819
147trabecula formation (GO:0060343)2.25182495
148skin morphogenesis (GO:0043589)2.24718392
149epithelial cell-cell adhesion (GO:0090136)2.24392244
150cell proliferation involved in metanephros development (GO:0072203)2.24035791
151branching involved in salivary gland morphogenesis (GO:0060445)2.22456562
152substrate adhesion-dependent cell spreading (GO:0034446)2.22142694
153extracellular matrix assembly (GO:0085029)2.21298955
154glomerular basement membrane development (GO:0032836)2.21247873
155renal system development (GO:0072001)2.21100119
156regulation of hippo signaling (GO:0035330)2.21054767
157dorsal/ventral axis specification (GO:0009950)2.20186317
158regulation of extracellular matrix disassembly (GO:0010715)2.20125835
159negative regulation of fatty acid transport (GO:2000192)2.19337944
160ruffle organization (GO:0031529)2.18877856
161hindlimb morphogenesis (GO:0035137)2.18610849

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_21828071_ChIP-Seq_BEAS2B_Human3.69414404
2NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.56476472
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.36491826
4TP63_17297297_ChIP-ChIP_HaCaT_Human3.06721381
5EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse3.02341581
6KDM2B_26808549_Chip-Seq_DND41_Human2.48335712
7KDM2B_26808549_Chip-Seq_SUP-B15_Human2.44895615
8MYC_22102868_ChIP-Seq_BL_Human2.40417469
9ELK3_25401928_ChIP-Seq_HUVEC_Human2.38555227
10WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.37827048
11E2F7_22180533_ChIP-Seq_HELA_Human2.35657139
12* EGR1_19374776_ChIP-ChIP_THP-1_Human2.32871705
13* VDR_21846776_ChIP-Seq_THP-1_Human2.29958033
14TCF7_22412390_ChIP-Seq_EML_Mouse2.24232164
15TRIM28_21343339_ChIP-Seq_HEK293_Human2.20784227
16KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.16965881
17RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.14475691
18ZNF263_19887448_ChIP-Seq_K562_Human2.09262223
19KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.04130796
20THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.02925015
21ZFP281_27345836_Chip-Seq_ESCs_Mouse2.00672625
22NFIB_24661679_ChIP-Seq_LUNG_Mouse1.99819341
23VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.97826962
24DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.92377286
25P300_27058665_Chip-Seq_ZR-75-30cells_Human1.91903816
26SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.89520779
27KDM2B_26808549_Chip-Seq_JURKAT_Human1.86940903
28WT1_19549856_ChIP-ChIP_CCG9911_Human1.85501418
29ZFP281_18757296_ChIP-ChIP_E14_Mouse1.77899509
30* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.76859173
31KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.76755011
32POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.75962502
33CLOCK_20551151_ChIP-Seq_293T_Human1.72414381
34EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.69563751
35ISL1_27105846_Chip-Seq_CPCs_Mouse1.69465106
36TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.66391405
37* KDM2B_26808549_Chip-Seq_K562_Human1.64305132
38RARG_19884340_ChIP-ChIP_MEFs_Mouse1.62446015
39MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.56574182
40TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.54802728
41* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.54486603
42SOX9_24532713_ChIP-Seq_HFSC_Mouse1.54274813
43FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.54025527
44* VDR_24763502_ChIP-Seq_THP-1_Human1.52562009
45RACK7_27058665_Chip-Seq_MCF-7_Human1.51152970
46PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.47895077
47* TP53_22127205_ChIP-Seq_IMR90_Human1.47861932
48ESR2_21235772_ChIP-Seq_MCF-7_Human1.47755688
49FOXO3_23340844_ChIP-Seq_DLD1_Human1.46782706
50CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.44478096
51* TBX20_22328084_ChIP-Seq_HEART_Mouse1.44428790
52* TBX20_22080862_ChIP-Seq_HEART_Mouse1.44428790
53STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.43286456
54TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.43208935
55KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.40748762
56EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.40026896
57KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.38249968
58SCL_19346495_ChIP-Seq_HPC-7_Human1.38133646
59ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.37201625
60ERG_21242973_ChIP-ChIP_JURKAT_Human1.36952310
61TP63_19390658_ChIP-ChIP_HaCaT_Human1.36544748
62TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.36073826
63FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.35858756
64ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.35055512
65HIF1A_21447827_ChIP-Seq_MCF-7_Human1.34104608
66EP300_21415370_ChIP-Seq_HL-1_Mouse1.33899902
67TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.33693719
68LXR_22292898_ChIP-Seq_THP-1_Human1.30946211
69CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.30145346
70NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.30014479
71SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.29477595
72DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.28580717
73* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.28412142
74UTX_26944678_Chip-Seq_JUKART_Human1.27650582
75MAF_26560356_Chip-Seq_TH1_Human1.27647209
76HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.27498281
77UBF1/2_26484160_Chip-Seq_HMECs_Human1.26394863
78* ATF3_27146783_Chip-Seq_COLON_Human1.26097236
79FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.25907165
80SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.24788159
81* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.24369079
82ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.23100989
83ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.22683350
84* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.22127715
85CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.21029523
86NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.20783697
87* NCOR1_26117541_ChIP-Seq_K562_Human1.20580681
88* RUNX1_27514584_Chip-Seq_MCF-7_Human1.20360078
89NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.19949015
90CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.18272556
91* BRD4_25478319_ChIP-Seq_HGPS_Human1.16859844
92KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.16630788
93KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.16630788
94KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.16630788
95SPI1_23127762_ChIP-Seq_K562_Human1.15732730
96RBPJ_22232070_ChIP-Seq_NCS_Mouse1.14898485
97TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14115019
98PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.11969806
99GATA1_19941826_ChIP-Seq_K562_Human1.11691158
100PPAR_26484153_Chip-Seq_NCI-H1993_Human1.11638798
101NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.10017545
102* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.09268777
103ESR1_15608294_ChIP-ChIP_MCF-7_Human1.08783612
104UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.07392543
105TP53_16413492_ChIP-PET_HCT116_Human1.07223638
106NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.06188276
107* CREB1_26743006_Chip-Seq_LNCaP_Human1.05277251
108* TP53_23651856_ChIP-Seq_MEFs_Mouse1.04599617
109CTCF_27219007_Chip-Seq_ERYTHROID_Human1.04399820
110MYC_19079543_ChIP-ChIP_MESCs_Mouse1.03484765
111CTNNB1_20460455_ChIP-Seq_HCT116_Human1.01413949
112TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01038357
113* TET1_21490601_ChIP-Seq_MESCs_Mouse0.97960357
114ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.97891358
115DROSHA_22980978_ChIP-Seq_HELA_Human0.97239893
116SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.96774013
117ZNF217_24962896_ChIP-Seq_MCF-7_Human0.96760347
118TET1_21451524_ChIP-Seq_MESCs_Mouse0.96450363
119RING1B_27294783_Chip-Seq_NPCs_Mouse0.95729459
120HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.95455233
121NANOG_21062744_ChIP-ChIP_HESCs_Human0.95233730
122BRD4_27068464_Chip-Seq_AML-cells_Mouse0.95081043
123SA1_27219007_Chip-Seq_ERYTHROID_Human0.94782873
124* SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.94090765
125* SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.94090765
126* PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.93728088
127CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.93351096
128SMC1_22415368_ChIP-Seq_MEFs_Mouse0.93348352
129KLF5_25053715_ChIP-Seq_YYC3_Human0.93329025
130AR_21909140_ChIP-Seq_LNCAP_Human0.93111965
131* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.93106332
132SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.92823513
133ESR1_20079471_ChIP-ChIP_T-47D_Human0.90127984
134* NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.89754879
135* OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.89699554

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.49084466
2MP0003705_abnormal_hypodermis_morpholog3.11328147
3MP0005623_abnormal_meninges_morphology2.88312037
4MP0000733_abnormal_muscle_development2.42015971
5MP0010030_abnormal_orbit_morphology2.32041985
6MP0002877_abnormal_melanocyte_morpholog2.21030348
7MP0004272_abnormal_basement_membrane2.16379434
8MP0003279_aneurysm2.07967532
9MP0004858_abnormal_nervous_system2.07310921
10MP0005275_abnormal_skin_tensile2.02451744
11MP0005503_abnormal_tendon_morphology1.97231391
12MP0000537_abnormal_urethra_morphology1.95218242
13MP0005076_abnormal_cell_differentiation1.94970275
14* MP0003385_abnormal_body_wall1.93399306
15MP0003566_abnormal_cell_adhesion1.92651834
16MP0010352_gastrointestinal_tract_polyps1.91011848
17MP0006054_spinal_hemorrhage1.80116276
18MP0001958_emphysema1.71231664
19MP0000428_abnormal_craniofacial_morphol1.70642131
20MP0005409_darkened_coat_color1.69585998
21MP0003300_gastrointestinal_ulcer1.68307744
22MP0009053_abnormal_anal_canal1.64905709
23MP0003115_abnormal_respiratory_system1.61395558
24MP0003091_abnormal_cell_migration1.57836252
25MP0001849_ear_inflammation1.57384016
26MP0003937_abnormal_limbs/digits/tail_de1.54544600
27MP0000767_abnormal_smooth_muscle1.54153942
28MP0009250_abnormal_appendicular_skeleto1.54133241
29MP0003941_abnormal_skin_development1.47588560
30* MP0009278_abnormal_bone_marrow1.46157917
31MP0000383_abnormal_hair_follicle1.45399193
32MP0003935_abnormal_craniofacial_develop1.42971375
33MP0010678_abnormal_skin_adnexa1.42077548
34MP0009384_cardiac_valve_regurgitation1.40902815
35MP0000534_abnormal_ureter_morphology1.40404757
36MP0005508_abnormal_skeleton_morphology1.39832111
37MP0002932_abnormal_joint_morphology1.39786673
38MP0003950_abnormal_plasma_membrane1.37258461
39MP0002925_abnormal_cardiovascular_devel1.35962391
40MP0005023_abnormal_wound_healing1.35778448
41MP0004185_abnormal_adipocyte_glucose1.34946886
42MP0004197_abnormal_fetal_growth/weight/1.34759914
43MP0005257_abnormal_intraocular_pressure1.34650156
44MP0004134_abnormal_chest_morphology1.33248736
45MP0002249_abnormal_larynx_morphology1.31114576
46MP0000678_abnormal_parathyroid_gland1.26095283
47MP0003942_abnormal_urinary_system1.23827594
48MP0000432_abnormal_head_morphology1.23544557
49MP0002697_abnormal_eye_size1.18892961
50* MP0010630_abnormal_cardiac_muscle1.17631756
51* MP0002092_abnormal_eye_morphology1.16129283
52MP0009672_abnormal_birth_weight1.15820726
53MP0004808_abnormal_hematopoietic_stem1.15810061
54MP0001915_intracranial_hemorrhage1.15513045
55* MP0002085_abnormal_embryonic_tissue1.15429034
56MP0010368_abnormal_lymphatic_system1.14642800
57MP0001348_abnormal_lacrimal_gland1.13705165
58MP0002084_abnormal_developmental_patter1.12952178
59MP0004233_abnormal_muscle_weight1.12688297
60MP0003755_abnormal_palate_morphology1.11897614
61MP0002060_abnormal_skin_morphology1.11170793
62MP0002108_abnormal_muscle_morphology1.10900408
63MP0000049_abnormal_middle_ear1.10483565
64MP0002396_abnormal_hematopoietic_system1.09485721
65MP0000569_abnormal_digit_pigmentation1.08442074
66MP0000003_abnormal_adipose_tissue1.08026139
67MP0000759_abnormal_skeletal_muscle1.06652010
68MP0001614_abnormal_blood_vessel1.06627775
69MP0005375_adipose_tissue_phenotype1.06288168
70MP0001299_abnormal_eye_distance/1.06192756
71MP0006138_congestive_heart_failure1.06140259
72MP0003984_embryonic_growth_retardation1.04933696
73MP0002088_abnormal_embryonic_growth/wei1.04090152
74MP0002111_abnormal_tail_morphology1.03426782
75MP0002282_abnormal_trachea_morphology1.02605406
76* MP0002116_abnormal_craniofacial_bone1.02344287
77MP0003303_peritoneal_inflammation1.01811491
78MP0003122_maternal_imprinting1.01590475
79MP0000762_abnormal_tongue_morphology1.00919235
80MP0001293_anophthalmia1.00314428
81MP0003045_fibrosis1.00219648
82MP0000566_synostosis0.99832238
83MP0005380_embryogenesis_phenotype0.99628668
84MP0001672_abnormal_embryogenesis/_devel0.99628668
85MP0003121_genomic_imprinting0.97720854
86* MP0002128_abnormal_blood_circulation0.97568913
87MP0000013_abnormal_adipose_tissue0.97418541
88MP0000920_abnormal_myelination0.96750657
89MP0005666_abnormal_adipose_tissue0.96409813
90MP0008932_abnormal_embryonic_tissue0.94883771
91MP0001879_abnormal_lymphatic_vessel0.94869415
92MP0003111_abnormal_nucleus_morphology0.94024587
93* MP0004087_abnormal_muscle_fiber0.93926376
94MP0005451_abnormal_body_composition0.92904408
95MP0003453_abnormal_keratinocyte_physiol0.91951855
96* MP0000266_abnormal_heart_morphology0.91908254
97MP0002896_abnormal_bone_mineralization0.90514889
98MP0002086_abnormal_extraembryonic_tissu0.90362529
99MP0002938_white_spotting0.89985001
100MP0004084_abnormal_cardiac_muscle0.89868814
101MP0003283_abnormal_digestive_organ0.89826258
102MP0002089_abnormal_postnatal_growth/wei0.88913965
103MP0001243_abnormal_dermal_layer0.88289125
104MP0009703_decreased_birth_body0.88241386
105MP0003938_abnormal_ear_development0.88146119
106MP0002796_impaired_skin_barrier0.87578763
107MP0002109_abnormal_limb_morphology0.87293260
108MP0000751_myopathy0.86825303
109MP0002114_abnormal_axial_skeleton0.86790758
110MP0010234_abnormal_vibrissa_follicle0.86648655
111* MP0001784_abnormal_fluid_regulation0.85027030
112MP0002233_abnormal_nose_morphology0.84839321
113MP0000747_muscle_weakness0.84501596
114MP0001730_embryonic_growth_arrest0.84394518
115MP0009780_abnormal_chondrocyte_physiolo0.83650492
116MP0000579_abnormal_nail_morphology0.83605724
117* MP0002080_prenatal_lethality0.82713382
118MP0005621_abnormal_cell_physiology0.82682316
119MP0000350_abnormal_cell_proliferation0.82393210
120MP0002113_abnormal_skeleton_development0.80920507
121MP0000163_abnormal_cartilage_morphology0.80555530
122MP0001697_abnormal_embryo_size0.80494017
123MP0004957_abnormal_blastocyst_morpholog0.77999932
124MP0005501_abnormal_skin_physiology0.77781996
125MP0001542_abnormal_bone_strength0.77613409
126MP0005171_absent_coat_pigmentation0.76536639
127MP0005197_abnormal_uvea_morphology0.75347223
128MP0009840_abnormal_foam_cell0.75222585

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)4.23760094
2Shallow orbits (HP:0000586)4.21133455
3Protrusio acetabuli (HP:0003179)4.07970234
4Cerebral aneurysm (HP:0004944)4.01223152
5Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.62400228
6Short 4th metacarpal (HP:0010044)3.62400228
7Broad metatarsal (HP:0001783)3.46895866
8Aortic dissection (HP:0002647)3.28727785
9Ankle contracture (HP:0006466)3.17286215
10Bladder diverticulum (HP:0000015)3.12135629
11Abnormality of the 4th metacarpal (HP:0010012)2.98653214
12Aortic aneurysm (HP:0004942)2.93746358
13Hyperacusis (HP:0010780)2.83684493
14Ulnar bowing (HP:0003031)2.82386560
15Mitral valve prolapse (HP:0001634)2.79238378
16Atrophic scars (HP:0001075)2.76287895
17Cervical subluxation (HP:0003308)2.75771334
18Neonatal short-limb short stature (HP:0008921)2.72066671
19Renal duplication (HP:0000075)2.70609374
20Disproportionate tall stature (HP:0001519)2.60750395
21Biconcave vertebral bodies (HP:0004586)2.57075909
22Vertebral compression fractures (HP:0002953)2.51740043
23Overriding aorta (HP:0002623)2.48888917
24Increased variability in muscle fiber diameter (HP:0003557)2.47064889
25Deviation of the hallux (HP:0010051)2.43819799
26Soft skin (HP:0000977)2.43545570
27Scapular winging (HP:0003691)2.42085826
28Hallux valgus (HP:0001822)2.39023056
29Buphthalmos (HP:0000557)2.33609316
30Asymmetry of the thorax (HP:0001555)2.33088672
31Dilatation of the ascending aorta (HP:0005111)2.32514544
32Bowel diverticulosis (HP:0005222)2.32169592
33Mildly elevated creatine phosphokinase (HP:0008180)2.30704175
34Flat cornea (HP:0007720)2.26664697
35Obstructive sleep apnea (HP:0002870)2.26526608
36Coronal craniosynostosis (HP:0004440)2.21654214
37Arnold-Chiari malformation (HP:0002308)2.20512853
38Renovascular hypertension (HP:0100817)2.19715523
39Broad face (HP:0000283)2.18721958
40Blue sclerae (HP:0000592)2.18294170
41Fragile skin (HP:0001030)2.15975409
42Arterial tortuosity (HP:0005116)2.14862311
43Abnormality of skeletal muscle fiber size (HP:0012084)2.12288083
44Distal upper limb amyotrophy (HP:0007149)2.11245065
45Upper limb amyotrophy (HP:0009129)2.11245065
46Ankyloglossia (HP:0010296)2.10535786
47Supernumerary ribs (HP:0005815)2.10217008
48Genu recurvatum (HP:0002816)2.08232020
49Breech presentation (HP:0001623)2.06223917
50Vascular tortuosity (HP:0004948)2.05541880
51Increased connective tissue (HP:0009025)2.04749621
52Distal lower limb amyotrophy (HP:0008944)2.04627879
53Elfin facies (HP:0004428)2.03749163
54Overgrowth (HP:0001548)2.03410749
55Natal tooth (HP:0000695)2.03286767
56Type 1 muscle fiber predominance (HP:0003803)2.03122548
57Premature skin wrinkling (HP:0100678)2.01520747
58Abnormality of the acetabulum (HP:0003170)2.00428022
59Abnormality of the calcaneus (HP:0008364)1.98939271
60Thin ribs (HP:0000883)1.98778267
61Macroorchidism (HP:0000053)1.96270849
62Abnormality of the distal phalanx of the thumb (HP:0009617)1.96214605
63Elbow flexion contracture (HP:0002987)1.96196478
64Peritonitis (HP:0002586)1.95981984
65Syringomyelia (HP:0003396)1.95412465
66Spinal cord lesions (HP:0100561)1.95412465
67Mitral regurgitation (HP:0001653)1.95299872
68Broad thumb (HP:0011304)1.94747385
69Achilles tendon contracture (HP:0001771)1.94490877
70Trigonocephaly (HP:0000243)1.94077726
71Increased density of long bones (HP:0006392)1.91843630
72Abnormality of the parietal bone (HP:0002696)1.91685275
73Aneurysm (HP:0002617)1.91073401
74Vertebral arch anomaly (HP:0008438)1.90166542
75Abnormality of oral frenula (HP:0000190)1.90023479
76Long eyelashes (HP:0000527)1.88260891
77Abnormality of the fingertips (HP:0001211)1.88091475
78Bell-shaped thorax (HP:0001591)1.87784022
79Hypoplastic ischia (HP:0003175)1.85671678
80Advanced eruption of teeth (HP:0006288)1.85225905
81Abnormality of the peritoneum (HP:0002585)1.84534295
82Thin bony cortex (HP:0002753)1.84371819
83Patellar dislocation (HP:0002999)1.83729373
84Ectopia lentis (HP:0001083)1.83334594
85Abnormal delivery (HP:0001787)1.82228641
86Increased nuchal translucency (HP:0010880)1.81703682
87Wormian bones (HP:0002645)1.81152667
88Rectal prolapse (HP:0002035)1.80949344
89Flat acetabular roof (HP:0003180)1.79954837
90Supernumerary bones of the axial skeleton (HP:0009144)1.79781372
91Spinal rigidity (HP:0003306)1.78761829
92Bicuspid aortic valve (HP:0001647)1.78463857
93Turricephaly (HP:0000262)1.77847596
94Narrow palate (HP:0000189)1.76553600
95Lower limb amyotrophy (HP:0007210)1.76332708
96Chin dimple (HP:0010751)1.76178266
97Wrist flexion contracture (HP:0001239)1.75692817
98Camptodactyly of toe (HP:0001836)1.75577938
99Wide anterior fontanel (HP:0000260)1.75251691
100Long palpebral fissure (HP:0000637)1.74929909
101Short nail (HP:0001799)1.74900749
102Pseudobulbar signs (HP:0002200)1.74506024
103Hyporeflexia of lower limbs (HP:0002600)1.74172082
104Hypoventilation (HP:0002791)1.73368876
105Arachnodactyly (HP:0001166)1.72417230
106Venous abnormality (HP:0002624)1.72024431
107Joint laxity (HP:0001388)1.71647364
108Broad ribs (HP:0000885)1.71321802
109Nonimmune hydrops fetalis (HP:0001790)1.71109589
110Follicular hyperkeratosis (HP:0007502)1.70068574
111Esophageal atresia (HP:0002032)1.69923768
112Bowing of the arm (HP:0006488)1.69795507
113Bowed forearm bones (HP:0003956)1.69795507
114Osteolytic defects of the phalanges of the hand (HP:0009771)1.69728216
115Osteolytic defects of the hand bones (HP:0009699)1.69728216
116Selective tooth agenesis (HP:0001592)1.69629746
117Muscle fiber splitting (HP:0003555)1.68481599
118Insomnia (HP:0100785)1.68423004
119Lymphangioma (HP:0100764)1.68291780
120Broad toe (HP:0001837)1.68160718
121Abnormality of dentin (HP:0010299)1.67569513
122Broad long bones (HP:0005622)1.67187801
123Hypoplasia of the iris (HP:0007676)1.66621148
124Inguinal hernia (HP:0000023)1.66524308
125Round ear (HP:0100830)1.66382623
126Hand muscle atrophy (HP:0009130)1.66185205
127Aortic regurgitation (HP:0001659)1.65732476
128Midface retrusion (HP:0011800)1.65438607
129Abnormality of the Achilles tendon (HP:0005109)1.65205081
130Protruding ear (HP:0000411)1.64708522
131Slender build (HP:0001533)1.64629239
132Abnormality of the phalanges of the hallux (HP:0010057)1.64317832
133Spondylolisthesis (HP:0003302)1.64310032
134Hyperextensible skin (HP:0000974)1.63898184
135Persistence of primary teeth (HP:0006335)1.63500890
136Hematochezia (HP:0002573)1.63405614
137Urethral obstruction (HP:0000796)1.62052629
138Tibial bowing (HP:0002982)1.61944133
139Limited elbow extension (HP:0001377)1.61397378
140Broad phalanges of the hand (HP:0009768)1.60975521
141Partial duplication of the phalanx of hand (HP:0009999)1.59379948
142Broad hallux (HP:0010055)1.57888013

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EEF2K3.58982267
2MAP3K103.45542667
3TRIB33.34381440
4PKN23.11166932
5ICK3.08166601
6SMG13.02820260
7TTN2.94601339
8CDK122.71858446
9EPHB12.51641573
10NTRK12.43252964
11LATS12.30253332
12PDGFRA2.25044257
13TGFBR22.13636188
14PTK62.13083012
15DDR22.12639043
16PRPF4B2.07874531
17SIK12.03576651
18CAMK1G1.98977643
19FGFR21.92955236
20FGFR41.92259034
21CAMK1D1.88735382
22DMPK1.68541950
23PAK41.64629326
24STK391.51656040
25RIPK11.49928220
26MTOR1.48998463
27STK101.41402665
28PDGFRB1.39259405
29BMX1.33281642
30MET1.29849707
31KSR21.28759676
32IRAK31.28720667
33BRD41.26088683
34CSF1R1.21566051
35* PAK21.19973365
36NEK21.19140487
37TYRO31.17237744
38EPHB21.12031206
39WNK11.09742336
40SIK21.06465875
41LRRK21.04197146
42PTK21.03391666
43CDK61.02122627
44MYLK1.01855289
45ERN10.98973722
46MST1R0.98373771
47RPS6KA20.97030325
48TRPM70.96995172
49RPS6KB20.95542066
50MARK20.95238861
51CSNK1A1L0.90542306
52FGFR10.88979793
53MOS0.88356616
54PRKD10.87868895
55MKNK10.86666090
56MAPK150.86501283
57MAP3K60.84142944
58ERBB40.83371360
59LMTK20.83078254
60PRKD20.81810663
61PKN10.80169895
62TESK10.78606027
63ROCK20.78147080
64CDK40.77365833
65ALK0.77104451
66DYRK1B0.75022700
67NEK90.71665259
68SCYL20.70927172
69MAP3K70.69331014
70MELK0.65156142
71CSK0.62622303
72STK380.62064191
73ARAF0.60974653
74KSR10.60626603
75PTK2B0.59412262
76RPS6KL10.58959456
77RPS6KC10.58959456
78UHMK10.58436963
79ERBB20.57739174
80PRKD30.56705781
81RET0.55986569
82BRAF0.55938993
83HIPK20.55705369
84FGR0.55335708
85PRKG20.55236996
86CDC42BPA0.54839610
87CDC70.54821043
88CDK90.54781342
89PASK0.54601632
90ROCK10.53730617
91ILK0.52075840
92CDK80.51212213
93LATS20.49937827
94CSNK1D0.49715232
95CSNK1G10.49690848
96TAOK20.49167964
97TIE10.49143053
98* STK30.48230199
99FLT30.47955167
100PRKCH0.46900533
101MAP4K10.46723399
102CDK70.45890168
103MAPK100.45255223
104MAPK10.45147088
105STK110.44882225
106MAPK110.44144253
107MAP2K30.43341634
108GSK3A0.42841554
109PAK30.40332687
110* INSR0.40133014
111MAPKAPK50.39761406
112CSNK1G30.39683942
113MAP3K130.39601975
114FGFR30.38743374
115AKT20.38686147
116WNK40.38102147
117CHEK10.37447786
118EPHA20.37445187
119PAK10.37376412
120* HCK0.37209936
121AKT30.37078293
122* SRC0.37047428
123CHEK20.36624105
124MAPKAPK20.36400488
125MAP3K20.35617660
126ITK0.34797827
127RAF10.34566042
128MAPK70.34488781
129CDK20.34093830
130PRKAA20.34061858
131MAP2K20.33852233
132* MAP3K80.33649711
133MKNK20.33071915
134AKT10.32472796
135RPS6KA60.32269210
136* CDK10.32172725
137MAP2K10.31359853
138PAK60.30702635
139PDPK10.30630778

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045122.42465768
2Basal cell carcinoma_Homo sapiens_hsa052172.28185315
3Focal adhesion_Homo sapiens_hsa045102.16758738
4Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.12698161
5Notch signaling pathway_Homo sapiens_hsa043302.11291769
6* Chronic myeloid leukemia_Homo sapiens_hsa052201.95975268
7Small cell lung cancer_Homo sapiens_hsa052221.93194281
8Proteoglycans in cancer_Homo sapiens_hsa052051.92555049
9Adherens junction_Homo sapiens_hsa045201.84890434
10Hedgehog signaling pathway_Homo sapiens_hsa043401.80785475
11Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.79414269
12* MicroRNAs in cancer_Homo sapiens_hsa052061.79161636
13Hippo signaling pathway_Homo sapiens_hsa043901.76768574
14Thyroid cancer_Homo sapiens_hsa052161.70633477
15Lysine degradation_Homo sapiens_hsa003101.67218972
16Renal cell carcinoma_Homo sapiens_hsa052111.59713360
17Leukocyte transendothelial migration_Homo sapiens_hsa046701.54995159
18AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.53347390
19Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.53066355
20Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.48699719
21Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.47068694
22Tight junction_Homo sapiens_hsa045301.43269366
23Dilated cardiomyopathy_Homo sapiens_hsa054141.41676598
24Regulation of actin cytoskeleton_Homo sapiens_hsa048101.40444442
25Prion diseases_Homo sapiens_hsa050201.39914716
26TGF-beta signaling pathway_Homo sapiens_hsa043501.37257687
27* Axon guidance_Homo sapiens_hsa043601.36810829
28Pancreatic cancer_Homo sapiens_hsa052121.36545609
29B cell receptor signaling pathway_Homo sapiens_hsa046621.35973192
30Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.33881515
31Prostate cancer_Homo sapiens_hsa052151.33349049
32Colorectal cancer_Homo sapiens_hsa052101.32526823
33Amoebiasis_Homo sapiens_hsa051461.32525234
34Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.30718530
35Protein digestion and absorption_Homo sapiens_hsa049741.29065177
36* Pathways in cancer_Homo sapiens_hsa052001.25453470
37Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.23140165
38Platelet activation_Homo sapiens_hsa046111.22654774
39Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.20422148
40PI3K-Akt signaling pathway_Homo sapiens_hsa041511.19804304
41Wnt signaling pathway_Homo sapiens_hsa043101.17865386
42Biosynthesis of amino acids_Homo sapiens_hsa012301.16341833
43HTLV-I infection_Homo sapiens_hsa051661.15782935
44Transcriptional misregulation in cancer_Homo sapiens_hsa052021.15502329
45Other glycan degradation_Homo sapiens_hsa005111.13898051
46Insulin signaling pathway_Homo sapiens_hsa049101.12803536
47Pentose phosphate pathway_Homo sapiens_hsa000301.12393878
48Glioma_Homo sapiens_hsa052141.08879951
49* Viral myocarditis_Homo sapiens_hsa054161.08212853
50Non-small cell lung cancer_Homo sapiens_hsa052231.08182529
51Rap1 signaling pathway_Homo sapiens_hsa040151.07504527
52Toxoplasmosis_Homo sapiens_hsa051451.07355066
53Dorso-ventral axis formation_Homo sapiens_hsa043201.06410404
54Bladder cancer_Homo sapiens_hsa052191.05887046
55Endometrial cancer_Homo sapiens_hsa052131.04709110
56mTOR signaling pathway_Homo sapiens_hsa041501.03973382
57Acute myeloid leukemia_Homo sapiens_hsa052211.01718019
58Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.01137866
59Osteoclast differentiation_Homo sapiens_hsa043801.00145799
60Thyroid hormone signaling pathway_Homo sapiens_hsa049190.98772968
61Phospholipase D signaling pathway_Homo sapiens_hsa040720.97313191
62Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.97162383
63mRNA surveillance pathway_Homo sapiens_hsa030150.95063732
64Viral carcinogenesis_Homo sapiens_hsa052030.94439767
65Endocytosis_Homo sapiens_hsa041440.93746421
66Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.93388670
67VEGF signaling pathway_Homo sapiens_hsa043700.90125455
68Estrogen signaling pathway_Homo sapiens_hsa049150.89986555
69Fructose and mannose metabolism_Homo sapiens_hsa000510.89723359
70Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.89067934
71Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.87420277
72Glycosaminoglycan degradation_Homo sapiens_hsa005310.86217023
73Insulin resistance_Homo sapiens_hsa049310.83834036
74Melanoma_Homo sapiens_hsa052180.83662570
75Galactose metabolism_Homo sapiens_hsa000520.83234516
762-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.82448773
77AMPK signaling pathway_Homo sapiens_hsa041520.81360589
78Central carbon metabolism in cancer_Homo sapiens_hsa052300.79445937
79Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.79434057
80GnRH signaling pathway_Homo sapiens_hsa049120.78523636
81Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.74885316
82Hepatitis B_Homo sapiens_hsa051610.74788370
83* Neurotrophin signaling pathway_Homo sapiens_hsa047220.74753963
84Melanogenesis_Homo sapiens_hsa049160.73753142
85* Cell cycle_Homo sapiens_hsa041100.73431248
86Longevity regulating pathway - mammal_Homo sapiens_hsa042110.73258648
87Thyroid hormone synthesis_Homo sapiens_hsa049180.72423758
88Malaria_Homo sapiens_hsa051440.72330575
89Inositol phosphate metabolism_Homo sapiens_hsa005620.70354342
90Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.69930296
91Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.69355283
92Cyanoamino acid metabolism_Homo sapiens_hsa004600.69334793
93Prolactin signaling pathway_Homo sapiens_hsa049170.69065271
94MAPK signaling pathway_Homo sapiens_hsa040100.67999213
95Carbon metabolism_Homo sapiens_hsa012000.67353534
96* ErbB signaling pathway_Homo sapiens_hsa040120.67342622
97FoxO signaling pathway_Homo sapiens_hsa040680.67165092
98Sphingolipid signaling pathway_Homo sapiens_hsa040710.66142600
99Choline metabolism in cancer_Homo sapiens_hsa052310.65780952
100Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.64011560
101* Ras signaling pathway_Homo sapiens_hsa040140.62507416
102Chemokine signaling pathway_Homo sapiens_hsa040620.60717842
103HIF-1 signaling pathway_Homo sapiens_hsa040660.60561813
104cGMP-PKG signaling pathway_Homo sapiens_hsa040220.60526687
105Apoptosis_Homo sapiens_hsa042100.60413088
106T cell receptor signaling pathway_Homo sapiens_hsa046600.59649479
107Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.59178430
108Salmonella infection_Homo sapiens_hsa051320.57516202
109Glucagon signaling pathway_Homo sapiens_hsa049220.55450787
110* Shigellosis_Homo sapiens_hsa051310.55403948
111Long-term potentiation_Homo sapiens_hsa047200.55361304
112p53 signaling pathway_Homo sapiens_hsa041150.52884785
113N-Glycan biosynthesis_Homo sapiens_hsa005100.52757882
114Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.52729535
115Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.51385523
116Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.51206704
117Spliceosome_Homo sapiens_hsa030400.49451731
118Adipocytokine signaling pathway_Homo sapiens_hsa049200.49154997
119Gap junction_Homo sapiens_hsa045400.48121234
120Ether lipid metabolism_Homo sapiens_hsa005650.47980745
121Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.47368428
122Type II diabetes mellitus_Homo sapiens_hsa049300.47289366
123NF-kappa B signaling pathway_Homo sapiens_hsa040640.46455034
124Vibrio cholerae infection_Homo sapiens_hsa051100.46334646
125Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.46138978
126Vitamin B6 metabolism_Homo sapiens_hsa007500.45351372
127Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.45273691
128Aldosterone synthesis and secretion_Homo sapiens_hsa049250.45117289
129Phosphatidylinositol signaling system_Homo sapiens_hsa040700.44840141

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