ABL2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the Abelson family of nonreceptor tyrosine protein kinases. The protein is highly similar to the c-abl oncogene 1 protein, including the tyrosine kinase, SH2 and SH3 domains, and it plays a role in cytoskeletal rearrangements through its C-terminal F-actin- and microtubule-binding sequences. This gene is expressed in both normal and tumor cells, and is involved in translocation with the ets variant 6 gene in leukemia. Multiple alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.32301318
2cell adhesion mediated by integrin (GO:0033627)4.98218370
3nuclear pore organization (GO:0006999)4.63552498
4hemidesmosome assembly (GO:0031581)4.61740429
5lymphangiogenesis (GO:0001946)4.52157042
6pre-miRNA processing (GO:0031054)4.45609012
7substrate-dependent cell migration (GO:0006929)4.34303303
8retina vasculature morphogenesis in camera-type eye (GO:0061299)4.32713520
9wound healing, spreading of epidermal cells (GO:0035313)4.18975678
10mitotic sister chromatid cohesion (GO:0007064)4.06251732
11pore complex assembly (GO:0046931)3.84723205
12regulation of hippo signaling (GO:0035330)3.79369289
13mitotic chromosome condensation (GO:0007076)3.75613094
14positive regulation of p38MAPK cascade (GO:1900745)3.72849826
15regulation of RNA export from nucleus (GO:0046831)3.70340363
16monoubiquitinated protein deubiquitination (GO:0035520)3.65709733
17regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.65434143
18paraxial mesoderm development (GO:0048339)3.54583429
19cytoplasmic mRNA processing body assembly (GO:0033962)3.52735602
20chondrocyte proliferation (GO:0035988)3.50596034
21endodermal cell differentiation (GO:0035987)3.44070417
22regulation of vitamin D biosynthetic process (GO:0060556)3.40888831
23negative regulation of hormone metabolic process (GO:0032351)3.40215338
24negative regulation of hormone biosynthetic process (GO:0032353)3.40215338
25endothelial cell morphogenesis (GO:0001886)3.32363974
26skin morphogenesis (GO:0043589)3.28255679
27wound healing, spreading of cells (GO:0044319)3.26367494
28histone H2A monoubiquitination (GO:0035518)3.25728819
29regulation of nucleobase-containing compound transport (GO:0032239)3.24985392
30heterochromatin organization (GO:0070828)3.24200687
31histone H3-K36 demethylation (GO:0070544)3.22821893
32heparan sulfate proteoglycan biosynthetic process (GO:0015012)3.17652515
33positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.17119420
34mitotic nuclear envelope disassembly (GO:0007077)3.14728160
35corticosteroid receptor signaling pathway (GO:0031958)3.14440458
36negative regulation of fatty acid transport (GO:2000192)3.13187806
37histone lysine demethylation (GO:0070076)3.12590524
38nuclear envelope disassembly (GO:0051081)3.11243815
39membrane disassembly (GO:0030397)3.11243815
40platelet-derived growth factor receptor signaling pathway (GO:0048008)3.07835563
41protein localization to kinetochore (GO:0034501)3.06963505
42negative regulation of systemic arterial blood pressure (GO:0003085)3.05669031
43cell-substrate junction assembly (GO:0007044)3.02433773
44negative regulation of histone methylation (GO:0031061)3.01672312
45dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.00653681
46artery development (GO:0060840)3.00424419
47histone demethylation (GO:0016577)2.99282419
48pericardium development (GO:0060039)2.98233292
49negative regulation of nitric-oxide synthase activity (GO:0051001)2.97106324
50neuron projection extension involved in neuron projection guidance (GO:1902284)2.94151185
51axon extension involved in axon guidance (GO:0048846)2.94151185
52sister chromatid cohesion (GO:0007062)2.93246026
53UDP-N-acetylglucosamine metabolic process (GO:0006047)2.92965040
54pattern specification involved in kidney development (GO:0061004)2.92463450
55NLS-bearing protein import into nucleus (GO:0006607)2.90805635
56cell migration involved in sprouting angiogenesis (GO:0002042)2.89613499
57mesenchymal-epithelial cell signaling (GO:0060638)2.85987272
58sprouting angiogenesis (GO:0002040)2.85792350
59glucocorticoid receptor signaling pathway (GO:0042921)2.85484249
60glomerular visceral epithelial cell development (GO:0072015)2.84371611
61regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.83050900
62endocardial cushion development (GO:0003197)2.82621799
63positive regulation of mitotic sister chromatid separation (GO:1901970)2.80685671
64positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.80685671
65positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.80685671
66histone H3-K9 methylation (GO:0051567)2.79019902
67vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.78917681
68regulation of membrane protein ectodomain proteolysis (GO:0051043)2.77457080
69endosome to melanosome transport (GO:0035646)2.77378988
70endosome to pigment granule transport (GO:0043485)2.77378988
71positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.76061237
72negative regulation of nitric oxide biosynthetic process (GO:0045019)2.75628416
73histone H3-K4 methylation (GO:0051568)2.75520605
74protein dealkylation (GO:0008214)2.75053584
75protein demethylation (GO:0006482)2.75053584
76regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.74479833
77negative regulation of DNA repair (GO:0045738)2.74372111
78notochord development (GO:0030903)2.74350549
79substrate adhesion-dependent cell spreading (GO:0034446)2.74204354
80regulation of transforming growth factor beta1 production (GO:0032908)2.74002007
81ganglion development (GO:0061548)2.72949568
82collagen fibril organization (GO:0030199)2.72420813
83blood vessel maturation (GO:0001955)2.72360125
84mesodermal cell differentiation (GO:0048333)2.72120871
85positive regulation of blood vessel endothelial cell migration (GO:0043536)2.71675852
86regulation of sister chromatid cohesion (GO:0007063)2.69923830
87membrane raft organization (GO:0031579)2.67860203
88negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.67854487
89regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.67032157
90apoptotic cell clearance (GO:0043277)2.66788175
91regulation of centriole replication (GO:0046599)2.66081550
92regulation of clathrin-mediated endocytosis (GO:2000369)2.65033126
93protein localization to chromosome, centromeric region (GO:0071459)2.64616562
94regulation of mitotic spindle organization (GO:0060236)2.64050920
95vascular endothelial growth factor signaling pathway (GO:0038084)2.62537444
96chromatin assembly (GO:0031497)2.62420805
97decidualization (GO:0046697)2.62093012
98peptidyl-lysine dimethylation (GO:0018027)2.62057319
99mitotic cytokinesis (GO:0000281)2.61578920
100gene silencing by RNA (GO:0031047)2.61224444
101smooth muscle tissue development (GO:0048745)2.59810925
102negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.59150354
103negative regulation of translation, ncRNA-mediated (GO:0040033)2.59150354
104regulation of translation, ncRNA-mediated (GO:0045974)2.59150354
105virion attachment to host cell (GO:0019062)2.57892071
106adhesion of symbiont to host cell (GO:0044650)2.57892071
107negative regulation of chondrocyte differentiation (GO:0032331)2.57883647
108regulation of gene silencing by miRNA (GO:0060964)2.57514849
109regulation of gene silencing by RNA (GO:0060966)2.57514849
110regulation of posttranscriptional gene silencing (GO:0060147)2.57514849
111histone H3-K9 demethylation (GO:0033169)2.57074108
112peptidyl-threonine phosphorylation (GO:0018107)2.56926089
113negative regulation of lipid storage (GO:0010888)2.56432713
114regulation of integrin-mediated signaling pathway (GO:2001044)2.55673630
115regulation of protein polyubiquitination (GO:1902914)2.55088144
116regulation of spindle organization (GO:0090224)2.54755805
117histone lysine methylation (GO:0034968)2.54627247
118regulation of translational termination (GO:0006449)2.53238985
119negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.52849346
120ovulation from ovarian follicle (GO:0001542)2.52109977
121regulation of p38MAPK cascade (GO:1900744)2.52078028
122sister chromatid segregation (GO:0000819)2.51865608
123response to magnesium ion (GO:0032026)2.51375922
124histone H4-K12 acetylation (GO:0043983)2.49951913
125cellular response to ATP (GO:0071318)2.49121213
126chondrocyte development (GO:0002063)2.48829799
127peptidyl-lysine trimethylation (GO:0018023)2.46956632
128negative regulation of adherens junction organization (GO:1903392)2.46441820
129negative regulation of focal adhesion assembly (GO:0051895)2.46441820
130negative regulation of cell junction assembly (GO:1901889)2.46441820
131spindle assembly involved in mitosis (GO:0090307)2.45991783
132neuron remodeling (GO:0016322)2.45322436
133microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.45229553
134stress granule assembly (GO:0034063)2.45200218
135nuclear envelope organization (GO:0006998)2.43380610
136negative regulation of anoikis (GO:2000811)2.42600201
137SMAD protein complex assembly (GO:0007183)2.41930362
138insulin-like growth factor receptor signaling pathway (GO:0048009)2.41391007
139negative regulation of monooxygenase activity (GO:0032769)2.40801706
140mitotic sister chromatid segregation (GO:0000070)2.40045721
141regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.39699202
142peptidyl-threonine modification (GO:0018210)2.38816244
143hippo signaling (GO:0035329)2.38448733
144bone remodeling (GO:0046849)2.38261321
145morphogenesis of an epithelial sheet (GO:0002011)2.37373753
146negative regulation of axon extension involved in axon guidance (GO:0048843)2.37359545
147protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.37036431
148protein localization to chromosome (GO:0034502)2.36861177
149positive regulation of astrocyte differentiation (GO:0048711)2.36828250
150protein localization to endosome (GO:0036010)2.36227973
151negative regulation of histone modification (GO:0031057)2.36186969
152piRNA metabolic process (GO:0034587)2.35862996
153branching involved in salivary gland morphogenesis (GO:0060445)2.35687248
154positive regulation of osteoblast proliferation (GO:0033690)2.34090525
155regulation of histone H3-K9 methylation (GO:0051570)2.34070402
156cellular response to vitamin (GO:0071295)2.33809800
157positive regulation of chemokine biosynthetic process (GO:0045080)2.33412444
158mitotic metaphase plate congression (GO:0007080)2.33262412
159regulation of mononuclear cell migration (GO:0071675)2.33233193
160positive regulation of chromosome segregation (GO:0051984)2.32557401
161positive regulation of fibroblast migration (GO:0010763)2.32552118
162negative regulation of vascular permeability (GO:0043116)2.32541789
163histone methylation (GO:0016571)2.31294511
164trophoblast giant cell differentiation (GO:0060707)2.31175135
165negative regulation of circadian rhythm (GO:0042754)2.30464799
166gene silencing (GO:0016458)2.30208912
167regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.29483752
168histone H3-K4 trimethylation (GO:0080182)2.29236389
169establishment of nucleus localization (GO:0040023)2.28720573
170kidney mesenchyme development (GO:0072074)2.28265743
171semaphorin-plexin signaling pathway (GO:0071526)2.27928868
172histone H4-K16 acetylation (GO:0043984)2.27095889
173negative chemotaxis (GO:0050919)2.26939241
174inner cell mass cell proliferation (GO:0001833)2.26142626
175DNA damage induced protein phosphorylation (GO:0006975)2.25454204
176RNA stabilization (GO:0043489)2.24816960
177mRNA stabilization (GO:0048255)2.24816960
178metaphase plate congression (GO:0051310)2.24702178
179regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.24633951
180histone phosphorylation (GO:0016572)2.23620596
181glomerular epithelial cell development (GO:0072310)2.22812723
182fibroblast migration (GO:0010761)2.22650195
183regulation of transforming growth factor beta2 production (GO:0032909)2.22474458
184meiotic chromosome segregation (GO:0045132)2.22439844
185cellular response to vitamin D (GO:0071305)2.22310635
186attachment of spindle microtubules to kinetochore (GO:0008608)2.22102436
187interkinetic nuclear migration (GO:0022027)2.21536505
188negative regulation of chromatin modification (GO:1903309)2.21453157
189regulation of establishment of cell polarity (GO:2000114)2.20974498
190plasma membrane repair (GO:0001778)2.20786910
191DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.20695022
192cytoskeleton-dependent cytokinesis (GO:0061640)2.19420072

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.06431836
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.49653237
3TP63_17297297_ChIP-ChIP_HaCaT_Human3.96721229
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.61318564
5TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.52929501
6SALL1_21062744_ChIP-ChIP_HESCs_Human3.49015393
7TRIM28_21343339_ChIP-Seq_HEK293_Human3.26316278
8NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.12566438
9BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.08829559
10SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.90314487
11* CJUN_26792858_Chip-Seq_BT549_Human2.77808614
12SMAD_19615063_ChIP-ChIP_OVARY_Human2.75067967
13* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.69856667
14ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.63040063
15GATA2_21666600_ChIP-Seq_HMVEC_Human2.62219956
16TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.59241294
17CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.36885436
18SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.32149509
19* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.08941118
20EP300_21415370_ChIP-Seq_HL-1_Mouse2.05116686
21TP53_18474530_ChIP-ChIP_U2OS_Human2.03138875
22ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.02086519
23* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.95480878
24WT1_19549856_ChIP-ChIP_CCG9911_Human1.93379082
25Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.92426416
26HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.89797572
27NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.87831264
28NRF2_20460467_ChIP-Seq_MEFs_Mouse1.87831264
29MYC_22102868_ChIP-Seq_BL_Human1.86968916
30EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.85069802
31PPAR_26484153_Chip-Seq_NCI-H1993_Human1.80423219
32TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.78999251
33AHR_22903824_ChIP-Seq_MCF-7_Human1.76608425
34* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.75065591
35FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.74631740
36EZH2_22144423_ChIP-Seq_EOC_Human1.72327837
37DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.72178832
38* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.72000869
39E2F4_17652178_ChIP-ChIP_JURKAT_Human1.68564997
40SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.66920971
41TP53_16413492_ChIP-PET_HCT116_Human1.66718859
42WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.66424736
43CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.64050246
44E2F1_21310950_ChIP-Seq_MCF-7_Human1.60083754
45STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.59652958
46RBPJ_22232070_ChIP-Seq_NCS_Mouse1.59608625
47ESR2_21235772_ChIP-Seq_MCF-7_Human1.56188963
48KDM2B_26808549_Chip-Seq_K562_Human1.55711216
49SALL4_18804426_ChIP-ChIP_XEN_Mouse1.55608935
50KDM2B_26808549_Chip-Seq_DND41_Human1.55245975
51TCF7_22412390_ChIP-Seq_EML_Mouse1.55083800
52* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.53397413
53NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.53212686
54RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.53106714
55RARG_19884340_ChIP-ChIP_MEFs_Mouse1.52349705
56ESR1_21235772_ChIP-Seq_MCF-7_Human1.51685564
57PKCTHETA_26484144_Chip-Seq_BREAST_Human1.51645760
58CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.48594033
59KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.48577852
60KDM2B_26808549_Chip-Seq_JURKAT_Human1.47248612
61TP63_23658742_ChIP-Seq_EP156T_Human1.46746550
62MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.46507263
63STAT6_21828071_ChIP-Seq_BEAS2B_Human1.44857020
64RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.44813475
65ZNF217_24962896_ChIP-Seq_MCF-7_Human1.44659339
66ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.44055498
67* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.41472384
68FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.39865007
69* RARB_27405468_Chip-Seq_BRAIN_Mouse1.39032252
70TP63_19390658_ChIP-ChIP_HaCaT_Human1.38597436
71NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.36265243
72KDM2B_26808549_Chip-Seq_SUP-B15_Human1.33310705
73FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.32905081
74SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.32288594
75* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.31832796
76* BRD4_25478319_ChIP-Seq_HGPS_Human1.31391481
77KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.31349280
78PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.31142028
79GBX2_23144817_ChIP-Seq_PC3_Human1.25831333
80ARNT_22903824_ChIP-Seq_MCF-7_Human1.24765499
81ZFP57_27257070_Chip-Seq_ESCs_Mouse1.24167784
82TCF4_18268006_ChIP-ChIP_LS174T_Human1.23885573
83CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.23592452
84NFIB_24661679_ChIP-Seq_LUNG_Mouse1.22013481
85TP53_22127205_ChIP-Seq_IMR90_Human1.20864245
86NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.18776442
87NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.18685754
88* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.18491686
89AR_21572438_ChIP-Seq_LNCaP_Human1.17897907
90CDX2_19796622_ChIP-Seq_MESCs_Mouse1.16608230
91* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.16605425
92ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.16181978
93POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.15865993
94TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15865993
95FUS_26573619_Chip-Seq_HEK293_Human1.15010741
96FOXM1_26456572_ChIP-Seq_MCF-7_Human1.14915079
97* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.14907446
98AR_21909140_ChIP-Seq_LNCAP_Human1.13634344
99ESR1_20079471_ChIP-ChIP_T-47D_Human1.13470926
100EED_16625203_ChIP-ChIP_MESCs_Mouse1.11864842
101TP53_23651856_ChIP-Seq_MEFs_Mouse1.11311220
102NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.06193722
103RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.05921003
104NOTCH1_21737748_ChIP-Seq_TLL_Human1.05690116
105MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.05007486
106EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.04533695
107PIAS1_25552417_ChIP-Seq_VCAP_Human1.04453891
108EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.04135044
109FOXO3_23340844_ChIP-Seq_DLD1_Human1.03868178
110HIF1A_21447827_ChIP-Seq_MCF-7_Human1.03502565
111* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.03258413
112STAT3_23295773_ChIP-Seq_U87_Human1.02354495
113ZFP281_18757296_ChIP-ChIP_E14_Mouse1.02071770
114* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.01510817
115ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.01358015
116YAP1_20516196_ChIP-Seq_MESCs_Mouse1.00737030
117AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.99652332
118MYB_21317192_ChIP-Seq_ERMYB_Mouse0.99630811
119TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.98817810
120ISL1_27105846_Chip-Seq_CPCs_Mouse0.97727872
121VDR_24787735_ChIP-Seq_THP-1_Human0.96491127
122SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.95520995
123* ATF3_27146783_Chip-Seq_COLON_Human0.95497901
124CTNNB1_20460455_ChIP-Seq_HCT116_Human0.94086054
125TBX3_20139965_ChIP-Seq_ESCs_Mouse0.93534681
126STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.93084022
127OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.91782262
128TBX3_20139965_ChIP-Seq_MESCs_Mouse0.91194128
129TBX20_22328084_ChIP-Seq_HEART_Mouse0.90000333
130TBX20_22080862_ChIP-Seq_HEART_Mouse0.90000333
131NR3C1_23031785_ChIP-Seq_PC12_Mouse0.89393178
132* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.88094566
133ELK3_25401928_ChIP-Seq_HUVEC_Human0.87825772
134* AR_19668381_ChIP-Seq_PC3_Human0.87583536
135DROSHA_22980978_ChIP-Seq_HELA_Human0.87331556
136SMAD3_21741376_ChIP-Seq_HESCs_Human0.86688017
137RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.86659497
138WT1_25993318_ChIP-Seq_PODOCYTE_Human0.86471243
139PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.86122397
140ELK4_26923725_Chip-Seq_MESODERM_Mouse0.85949127
141PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.84826401
142CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.83822294
143GATA1_26923725_Chip-Seq_HPCs_Mouse0.83602385
144* UBF1/2_26484160_Chip-Seq_HMECs_Human0.83536803
145TCF4_23295773_ChIP-Seq_U87_Human0.82565250
146SOX2_21211035_ChIP-Seq_LN229_Gbm0.82505986
147EWS_26573619_Chip-Seq_HEK293_Human0.82017667
148* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.79864560
149TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.79299042
150RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.78687322
151DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.78651053
152SMAD4_21799915_ChIP-Seq_A2780_Human0.77791223
153* SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.75766383
154* SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.75766383
155NANOG_21062744_ChIP-ChIP_HESCs_Human0.74418479
156FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.74332270
157RING1B_27294783_Chip-Seq_NPCs_Mouse0.74311249
158* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.74209805
159RUNX1_26923725_Chip-Seq_HPCs_Mouse0.73833456
160MYCN_18555785_ChIP-Seq_MESCs_Mouse0.73294988
161RXR_22108803_ChIP-Seq_LS180_Human0.72560944

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003950_abnormal_plasma_membrane5.30181630
2MP0008438_abnormal_cutaneous_collagen3.91409882
3MP0004272_abnormal_basement_membrane3.35887330
4MP0010368_abnormal_lymphatic_system3.13945363
5MP0000569_abnormal_digit_pigmentation3.09877736
6MP0004859_abnormal_synaptic_plasticity2.78184444
7MP0003787_abnormal_imprinting2.72416613
8MP0005076_abnormal_cell_differentiation2.43975480
9MP0010352_gastrointestinal_tract_polyps2.43834491
10MP0003111_abnormal_nucleus_morphology2.33934651
11MP0008057_abnormal_DNA_replication2.30374162
12MP0006054_spinal_hemorrhage2.29882074
13MP0001879_abnormal_lymphatic_vessel2.28170507
14MP0010307_abnormal_tumor_latency2.25867953
15MP0003705_abnormal_hypodermis_morpholog2.21561003
16MP0008877_abnormal_DNA_methylation2.17254633
17MP0005171_absent_coat_pigmentation2.16067522
18MP0005275_abnormal_skin_tensile2.07950736
19MP0002877_abnormal_melanocyte_morpholog2.07196005
20MP0003890_abnormal_embryonic-extraembry2.06078220
21MP0010094_abnormal_chromosome_stability2.02819639
22MP0003941_abnormal_skin_development2.02740210
23MP0003077_abnormal_cell_cycle2.02739942
24MP0005623_abnormal_meninges_morphology2.02476332
25MP0003279_aneurysm2.02042907
26MP0008007_abnormal_cellular_replicative1.85361294
27MP0002332_abnormal_exercise_endurance1.85264137
28MP0003091_abnormal_cell_migration1.80690722
29MP0000350_abnormal_cell_proliferation1.78458968
30MP0002084_abnormal_developmental_patter1.72648161
31MP0003828_pulmonary_edema1.69463814
32MP0009840_abnormal_foam_cell1.69298774
33MP0003121_genomic_imprinting1.69208325
34MP0004185_abnormal_adipocyte_glucose1.67425133
35MP0000015_abnormal_ear_pigmentation1.67120692
36MP0000371_diluted_coat_color1.65711094
37MP0005409_darkened_coat_color1.65517010
38MP0001730_embryonic_growth_arrest1.63649986
39MP0001672_abnormal_embryogenesis/_devel1.60197721
40MP0005380_embryogenesis_phenotype1.60197721
41MP0005595_abnormal_vascular_smooth1.58841651
42MP0000733_abnormal_muscle_development1.58773950
43MP0003123_paternal_imprinting1.56741175
44MP0003984_embryonic_growth_retardation1.52287137
45MP0002088_abnormal_embryonic_growth/wei1.49369916
46MP0002085_abnormal_embryonic_tissue1.47223397
47MP0004808_abnormal_hematopoietic_stem1.47046638
48MP0001849_ear_inflammation1.46605271
49MP0008961_abnormal_basal_metabolism1.44247259
50MP0001697_abnormal_embryo_size1.42581107
51MP0002086_abnormal_extraembryonic_tissu1.42055934
52MP0005197_abnormal_uvea_morphology1.41451771
53MP0002896_abnormal_bone_mineralization1.37459224
54MP0003453_abnormal_keratinocyte_physiol1.36381738
55MP0003937_abnormal_limbs/digits/tail_de1.35992028
56MP0001299_abnormal_eye_distance/1.35725314
57MP0001542_abnormal_bone_strength1.35032087
58MP0005167_abnormal_blood-brain_barrier1.32324020
59MP0001348_abnormal_lacrimal_gland1.31860390
60MP0004197_abnormal_fetal_growth/weight/1.31635835
61MP0001958_emphysema1.30296788
62MP0010030_abnormal_orbit_morphology1.28345154
63MP0003385_abnormal_body_wall1.27118309
64MP0002060_abnormal_skin_morphology1.26728048
65MP0003566_abnormal_cell_adhesion1.24927598
66MP0002653_abnormal_ependyma_morphology1.24573808
67MP0003935_abnormal_craniofacial_develop1.24226064
68MP0005174_abnormal_tail_pigmentation1.23904165
69MP0000428_abnormal_craniofacial_morphol1.22180438
70MP0001915_intracranial_hemorrhage1.22077960
71MP0000343_altered_response_to1.21424189
72MP0004270_analgesia1.21253685
73MP0000749_muscle_degeneration1.20375867
74MP0003755_abnormal_palate_morphology1.19461745
75MP0003693_abnormal_embryo_hatching1.18398749
76MP0010678_abnormal_skin_adnexa1.16520962
77MP0002925_abnormal_cardiovascular_devel1.15693532
78MP0004957_abnormal_blastocyst_morpholog1.15008468
79MP0003861_abnormal_nervous_system1.13380849
80MP0005508_abnormal_skeleton_morphology1.12876632
81MP0010234_abnormal_vibrissa_follicle1.11760921
82MP0005503_abnormal_tendon_morphology1.11249833
83MP0000432_abnormal_head_morphology1.11141855
84MP0002295_abnormal_pulmonary_circulatio1.10979572
85MP0009278_abnormal_bone_marrow1.10815989
86MP0005164_abnormal_response_to1.08499367
87MP0003191_abnormal_cellular_cholesterol1.08151529
88MP0003045_fibrosis1.07960096
89MP0009780_abnormal_chondrocyte_physiolo1.06119287
90MP0003303_peritoneal_inflammation1.03013927
91MP0005621_abnormal_cell_physiology1.02990932
92MP0004510_myositis1.02803793
93MP0002998_abnormal_bone_remodeling1.02371865
94MP0005257_abnormal_intraocular_pressure1.01187203
95MP0005187_abnormal_penis_morphology0.99217735
96MP0003635_abnormal_synaptic_transmissio0.98551064
97MP0002396_abnormal_hematopoietic_system0.97323442
98MP0000762_abnormal_tongue_morphology0.95843772
99MP0003119_abnormal_digestive_system0.95515024
100MP0002080_prenatal_lethality0.95313233
101MP0002168_other_aberrant_phenotype0.95261210
102MP0000383_abnormal_hair_follicle0.95125867
103MP0005408_hypopigmentation0.92384977
104MP0005058_abnormal_lysosome_morphology0.92145558
105MP0009703_decreased_birth_body0.92111855
106MP0003115_abnormal_respiratory_system0.91877536
107MP0005193_abnormal_anterior_eye0.91771450
108MP0000778_abnormal_nervous_system0.91277715
109MP0004233_abnormal_muscle_weight0.89105215
110MP0009384_cardiac_valve_regurgitation0.87738695
111MP0003283_abnormal_digestive_organ0.86678839
112MP0002075_abnormal_coat/hair_pigmentati0.86662529
113MP0006292_abnormal_olfactory_placode0.86220659
114MP0005397_hematopoietic_system_phenotyp0.85761815
115MP0001545_abnormal_hematopoietic_system0.85761815
116MP0005165_increased_susceptibility_to0.85539768
117MP0002116_abnormal_craniofacial_bone0.84380576
118MP0003448_altered_tumor_morphology0.84129718
119MP0009672_abnormal_birth_weight0.83976898
120MP0004084_abnormal_cardiac_muscle0.83100757
121MP0008058_abnormal_DNA_repair0.82963047
122MP0002092_abnormal_eye_morphology0.80857985
123MP0005248_abnormal_Harderian_gland0.80470097
124MP0001186_pigmentation_phenotype0.79849524
125MP0000767_abnormal_smooth_muscle0.79526055
126MP0008770_decreased_survivor_rate0.77986385
127MP0003632_abnormal_nervous_system0.77582407
128MP0009697_abnormal_copulation0.77185034
129MP0002210_abnormal_sex_determination0.77106531
130* MP0002063_abnormal_learning/memory/cond0.76935152
131* MP0002152_abnormal_brain_morphology0.76585305
132MP0005451_abnormal_body_composition0.75476827
133MP0005384_cellular_phenotype0.74014166
134MP0002114_abnormal_axial_skeleton0.72978915
135MP0002128_abnormal_blood_circulation0.71714128
136MP0000163_abnormal_cartilage_morphology0.71497093
137MP0003300_gastrointestinal_ulcer0.71384112
138MP0001243_abnormal_dermal_layer0.71273136
139MP0001216_abnormal_epidermal_layer0.71024286
140MP0002095_abnormal_skin_pigmentation0.70943102
141MP0000266_abnormal_heart_morphology0.70476597
142MP0002234_abnormal_pharynx_morphology0.70228430
143MP0002109_abnormal_limb_morphology0.70119199
144MP0000013_abnormal_adipose_tissue0.69882350
145MP0000759_abnormal_skeletal_muscle0.68594155
146MP0009053_abnormal_anal_canal0.68320134
147MP0001784_abnormal_fluid_regulation0.68005941
148MP0002089_abnormal_postnatal_growth/wei0.67790094
149MP0002081_perinatal_lethality0.67415616
150MP0000427_abnormal_hair_cycle0.67369453
151MP0002177_abnormal_outer_ear0.66561465
152MP0004811_abnormal_neuron_physiology0.65869630
153MP0002113_abnormal_skeleton_development0.65823577
154MP0009250_abnormal_appendicular_skeleto0.64026410
155MP0005023_abnormal_wound_healing0.63806515
156MP0003942_abnormal_urinary_system0.62734551
157MP0000537_abnormal_urethra_morphology0.62455866
158MP0000653_abnormal_sex_gland0.61942961
159* MP0001929_abnormal_gametogenesis0.61614840
160MP0004134_abnormal_chest_morphology0.61545939
161MP0008932_abnormal_embryonic_tissue0.61372119
162MP0000534_abnormal_ureter_morphology0.60508713
163MP0001614_abnormal_blood_vessel0.60493409
164MP0003699_abnormal_female_reproductive0.59645242

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)3.80920264
2Premature rupture of membranes (HP:0001788)3.50079889
3Spondylolisthesis (HP:0003302)3.43303111
4Abnormality of glycolipid metabolism (HP:0010969)3.37271143
5Abnormality of liposaccharide metabolism (HP:0010968)3.37271143
6Abnormality of glycosphingolipid metabolism (HP:0004343)3.37271143
7Short nail (HP:0001799)3.16940165
8Aortic aneurysm (HP:0004942)3.07201894
9Atrophic scars (HP:0001075)3.06898540
10Arterial tortuosity (HP:0005116)3.04989932
11Aortic dissection (HP:0002647)3.01499848
12Vascular tortuosity (HP:0004948)2.90767769
13Papillary thyroid carcinoma (HP:0002895)2.80871294
14Osteolytic defects of the hand bones (HP:0009699)2.68033278
15Osteolytic defects of the phalanges of the hand (HP:0009771)2.68033278
16Mitral stenosis (HP:0001718)2.65083182
17Abnormality of the fingertips (HP:0001211)2.57214500
18Absent frontal sinuses (HP:0002688)2.53898913
19Volvulus (HP:0002580)2.53672587
20Thick nail (HP:0001805)2.49228780
21Abnormality of the astrocytes (HP:0100707)2.46384446
22Astrocytoma (HP:0009592)2.46384446
23Natal tooth (HP:0000695)2.45389699
24Urethral obstruction (HP:0000796)2.44221913
25Facial hemangioma (HP:0000329)2.42737687
26Overgrowth (HP:0001548)2.42006694
27Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.41024133
28Tibial bowing (HP:0002982)2.36424287
29Spinal rigidity (HP:0003306)2.32497330
30Aortic regurgitation (HP:0001659)2.31628253
31Vertebral compression fractures (HP:0002953)2.31382875
32Abnormality of the frontal sinuses (HP:0002687)2.31352046
33Follicular hyperkeratosis (HP:0007502)2.30897712
34Genu recurvatum (HP:0002816)2.29682655
35Hyperacusis (HP:0010780)2.27585515
36Short 4th metacarpal (HP:0010044)2.24735235
37Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.24735235
38Neurofibrillary tangles (HP:0002185)2.20693392
39Bradycardia (HP:0001662)2.19622577
40Distal lower limb amyotrophy (HP:0008944)2.16931351
41Heterotopia (HP:0002282)2.16326297
42Wormian bones (HP:0002645)2.16042807
43Chromsome breakage (HP:0040012)2.15792430
44Ependymoma (HP:0002888)2.12847879
45Broad thumb (HP:0011304)2.12501004
46Entropion (HP:0000621)2.12404247
47Lower limb amyotrophy (HP:0007210)2.11300360
48Long eyelashes (HP:0000527)2.10517724
49Mitral valve prolapse (HP:0001634)2.09586928
50Chromosomal breakage induced by crosslinking agents (HP:0003221)2.06991152
51Ectopic kidney (HP:0000086)2.06324923
52Subacute progressive viral hepatitis (HP:0006572)2.04431907
53Myocardial infarction (HP:0001658)2.04071934
54Shawl scrotum (HP:0000049)2.04019242
55Hypopigmentation of the fundus (HP:0007894)2.03183762
56Aplasia cutis congenita (HP:0001057)2.02915674
57Nuclear cataract (HP:0100018)2.02785807
58Shallow orbits (HP:0000586)2.01287139
59Hypoplastic ischia (HP:0003175)2.00684251
60Hypoplasia of the iris (HP:0007676)1.99002742
61Cerebral aneurysm (HP:0004944)1.98547655
62Long toe (HP:0010511)1.98502942
63Genetic anticipation (HP:0003743)1.96645500
64Knee flexion contracture (HP:0006380)1.94948436
65Transitional cell carcinoma of the bladder (HP:0006740)1.93417400
66Increased number of teeth (HP:0011069)1.93343225
67Hematochezia (HP:0002573)1.92548468
68Aortic valve stenosis (HP:0001650)1.91116185
69Elfin facies (HP:0004428)1.90968373
70Renovascular hypertension (HP:0100817)1.90041700
71Persistence of primary teeth (HP:0006335)1.89678769
72Elbow flexion contracture (HP:0002987)1.89554122
73Thoracolumbar scoliosis (HP:0002944)1.88244507
74Sandal gap (HP:0001852)1.87798482
75Tetraparesis (HP:0002273)1.87334836
76Bowel diverticulosis (HP:0005222)1.86148874
77Hyporeflexia of lower limbs (HP:0002600)1.86105305
78Reduced subcutaneous adipose tissue (HP:0003758)1.85832095
79Submucous cleft hard palate (HP:0000176)1.85595050
80Macroorchidism (HP:0000053)1.85035909
81Radial bowing (HP:0002986)1.84719278
82Bladder carcinoma (HP:0002862)1.84710290
83Bladder neoplasm (HP:0009725)1.84710290
84Pointed chin (HP:0000307)1.83990726
85Coxa valga (HP:0002673)1.83909021
86Abnormality of the distal phalanges of the toes (HP:0010182)1.83808875
87Cubitus valgus (HP:0002967)1.83137565
88Ulnar bowing (HP:0003031)1.82856515
89Cerebral inclusion bodies (HP:0100314)1.82690735
90Leiomyosarcoma (HP:0100243)1.81753392
91Uterine leiomyosarcoma (HP:0002891)1.81753392
92Glioma (HP:0009733)1.81485622
93Acute myeloid leukemia (HP:0004808)1.81437897
94Focal motor seizures (HP:0011153)1.81271608
95Ovoid vertebral bodies (HP:0003300)1.80998516
96Flat cornea (HP:0007720)1.80617548
97Fragile skin (HP:0001030)1.80506261
98Difficulty climbing stairs (HP:0003551)1.79598035
99Abnormality of the odontoid process (HP:0003310)1.78825407
100Broad phalanges of the hand (HP:0009768)1.78409595
101Cardiovascular calcification (HP:0011915)1.77357984
102Broad face (HP:0000283)1.76399605
103Abnormality of the labia minora (HP:0012880)1.76090943
104Cervical subluxation (HP:0003308)1.75557060
105Overriding aorta (HP:0002623)1.75136850
106Limited elbow extension (HP:0001377)1.74738131
107Increased nuchal translucency (HP:0010880)1.74484387
108Broad phalanx (HP:0006009)1.73200418
109Syringomyelia (HP:0003396)1.72859841
110Spinal cord lesions (HP:0100561)1.72859841
111Renal duplication (HP:0000075)1.72758734
112Asymmetry of the thorax (HP:0001555)1.71930393
113Soft skin (HP:0000977)1.70054313
114Mitral regurgitation (HP:0001653)1.69590329
115Urinary bladder sphincter dysfunction (HP:0002839)1.67554708
116Short chin (HP:0000331)1.67420697
117Impaired smooth pursuit (HP:0007772)1.67149181
118Abnormality of the lower motor neuron (HP:0002366)1.66809968
119Albinism (HP:0001022)1.66381421
120Pulmonic stenosis (HP:0001642)1.66227603
121Sensory axonal neuropathy (HP:0003390)1.66206452
122Trigonocephaly (HP:0000243)1.66065067
123Broad finger (HP:0001500)1.65167583
124Limited hip movement (HP:0008800)1.65167374
125Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.64864828
126Abnormality of the epiphyses of the hand (HP:0005924)1.64206301
127Overlapping toe (HP:0001845)1.63961773
128Narrow palate (HP:0000189)1.63931846
129Prominent nose (HP:0000448)1.63788645
130Thin bony cortex (HP:0002753)1.63542679
131Milia (HP:0001056)1.63517795
132Abnormality of the distal phalanx of the thumb (HP:0009617)1.62529358
133Deviation of the thumb (HP:0009603)1.62324470
134Thyroid carcinoma (HP:0002890)1.62213960
135Broad long bones (HP:0005622)1.61999388
136Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.61530230
137Obsessive-compulsive behavior (HP:0000722)1.59244751
138Abnormality of the ischium (HP:0003174)1.59020103
139Neoplasm of the oral cavity (HP:0100649)1.58894689
140Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.58587807
141Dysmetric saccades (HP:0000641)1.58320038
142Abnormality of the acetabulum (HP:0003170)1.57824733
143Malignant gastrointestinal tract tumors (HP:0006749)1.57191457
144Gastrointestinal carcinoma (HP:0002672)1.57191457
145Aneurysm (HP:0002617)1.57014253
146Fused cervical vertebrae (HP:0002949)1.56960465
147Sparse lateral eyebrow (HP:0005338)1.56856736
148Wrist flexion contracture (HP:0001239)1.56632805
149Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.55287179
150Neoplasm of the adrenal cortex (HP:0100641)1.55160669
151Ankle contracture (HP:0006466)1.55113571
152Bilateral sensorineural hearing impairment (HP:0008619)1.54931964
153Neonatal short-limb short stature (HP:0008921)1.54911454
154Abnormality of ocular smooth pursuit (HP:0000617)1.54626929
155Coxa vara (HP:0002812)1.54617637
156Increased density of long bones (HP:0006392)1.54616115
157Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.53188676
158Increased connective tissue (HP:0009025)1.53110747
159Abnormality of the carotid arteries (HP:0005344)1.52810075
160Cystic hygroma (HP:0000476)1.52323814
161Bowing of the arm (HP:0006488)1.52249765
162Bowed forearm bones (HP:0003956)1.52249765
163Enlarged penis (HP:0000040)1.52110846
164Deep palmar crease (HP:0006191)1.51801688
165Chin dimple (HP:0010751)1.51381279
166Bladder diverticulum (HP:0000015)1.51211132
167Pelvic girdle muscle weakness (HP:0003749)1.50252279
168Abnormality of the nasal septum (HP:0000419)1.50176304
169Broad palm (HP:0001169)1.47968318
170Aqueductal stenosis (HP:0002410)1.47497119
171Anal stenosis (HP:0002025)1.46423105
172Metaphyseal cupping (HP:0003021)1.46389904
173Pes planus (HP:0001763)1.45691868
174Mild short stature (HP:0003502)1.45423970
175Relative macrocephaly (HP:0004482)1.45411608
176Epiphyseal dysplasia (HP:0002656)1.44416193
177Megalocornea (HP:0000485)1.44130529

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS16.42015411
2LATS24.89946998
3CDK124.22226139
4IRAK34.21448195
5STK38L3.59114060
6MST1R3.03577556
7TGFBR22.80992094
8AKT32.79212453
9TIE12.57586437
10CDC72.56471818
11MET2.52156980
12STK32.45497396
13TRPM72.41823659
14TAOK12.10179366
15MAP3K42.07447068
16MAP3K92.03931712
17STK382.02919736
18MAP3K61.98353868
19EPHA41.91652764
20NEK91.79538682
21EEF2K1.78126044
22NTRK31.77548382
23PAK61.74642098
24PIM21.67264198
25CAMK1D1.57571003
26CAMK1G1.42508614
27PRKD31.37722201
28NEK21.37510403
29KSR21.36541491
30DMPK1.32850992
31GRK71.32568640
32DDR21.30284826
33PKN21.29196815
34TYRO31.27924150
35EPHB21.26704770
36NTRK11.21828513
37RAF11.14578609
38MYLK1.12005341
39KSR11.11214907
40TTK1.09753067
41ERBB41.06440844
42CHEK21.05056099
43DYRK31.04857927
44RIPK11.02564277
45PDGFRA1.02379137
46TGFBR11.02037392
47TTN1.01605126
48MTOR1.00804229
49TRIB30.97401586
50ALK0.97270161
51EIF2AK30.96948581
52PAK40.96365987
53CDK80.95219536
54NME20.94868863
55LIMK10.93931861
56BRD40.93770923
57RET0.92853512
58GSK3A0.91185848
59MELK0.90099316
60CDK90.89587895
61CHEK10.88407802
62PLK20.88400899
63RPS6KA20.85526668
64SGK20.85238274
65CDC42BPA0.85146161
66ADRBK20.84056179
67MOS0.81937887
68SCYL20.80023493
69INSRR0.79185031
70ATM0.77595027
71MARK20.77577881
72MAP3K20.77562417
73PAK20.76860027
74CLK10.75870382
75BMPR1B0.74263902
76MAPK100.73947410
77CDK70.73303662
78NTRK20.71424106
79ERBB30.69122194
80PLK40.68103630
81CHUK0.67167412
82PDK20.66559245
83WNK10.65174536
84* PDGFRB0.64002779
85CDK40.62918202
86CDK20.62285223
87MAP3K140.62018026
88CSNK1D0.61515426
89CDK60.61327560
90FES0.61223649
91SIK20.60731233
92MAP3K50.60685562
93PBK0.58028864
94ROCK10.57938629
95MAP3K100.57667993
96FLT30.57374808
97ICK0.57208570
98BMX0.56761267
99STK100.56647931
100CAMKK10.56424433
101PTK2B0.55607154
102* ABL20.54821883
103FRK0.53253482
104PRKD20.53191007
105STK240.53126718
106MAP3K120.52755224
107CDK10.52639700
108MAP3K80.51215322
109STK110.51086857
110PLK30.50816307
111SGK10.49785097
112ATR0.49095262
113ADRBK10.49018472
114ACVR1B0.46552570
115MARK30.46395546
116EPHA20.45317073
117AURKB0.45238422
118TAOK20.45143889
119SGK30.44949878
120MAPK140.44256820
121PRKDC0.43533152
122GSK3B0.43129264
123FGFR30.42903866
124MAP2K30.42144063
125MAP3K30.41502752
126CSNK1A1L0.40723682
127PLK10.40280683
128RPS6KA60.39676360
129MKNK20.39307618
130* ABL10.39081527
131MAP2K70.38444810
132PNCK0.37760942
133DAPK30.37394539
134PTK20.37017885
135RIPK40.36916243
136MAP2K40.36013524
137NUAK10.35941074
138FER0.35352141
139SGK2230.34746092
140SGK4940.34746092
141RPS6KL10.33630887
142RPS6KC10.33630887
143FGFR10.33457361
144DYRK1A0.33426893
145CSNK1E0.33163458
146AKT10.33131789
147FGR0.32620341
148PKN10.31302393
149* INSR0.30705225
150NEK10.30700235
151CSNK1G20.30629398
152PRKCH0.30160726
153FGFR20.29843521
154MAPKAPK50.29506428

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan degradation_Homo sapiens_hsa005311.92445627
2Lysosome_Homo sapiens_hsa041421.70395451
3Malaria_Homo sapiens_hsa051441.68474466
4MicroRNAs in cancer_Homo sapiens_hsa052061.65981393
5mTOR signaling pathway_Homo sapiens_hsa041501.50983868
6Dorso-ventral axis formation_Homo sapiens_hsa043201.48550964
7Long-term potentiation_Homo sapiens_hsa047201.47551798
8Glioma_Homo sapiens_hsa052141.42185792
9Chronic myeloid leukemia_Homo sapiens_hsa052201.41180111
10Amoebiasis_Homo sapiens_hsa051461.36473669
11Cell cycle_Homo sapiens_hsa041101.33508809
12Colorectal cancer_Homo sapiens_hsa052101.29225533
13Pancreatic cancer_Homo sapiens_hsa052121.27529711
14Adherens junction_Homo sapiens_hsa045201.26708140
15Salmonella infection_Homo sapiens_hsa051321.25874175
16Endometrial cancer_Homo sapiens_hsa052131.25630330
17Thyroid hormone signaling pathway_Homo sapiens_hsa049191.25630134
18NOD-like receptor signaling pathway_Homo sapiens_hsa046211.24976898
19TGF-beta signaling pathway_Homo sapiens_hsa043501.20516117
20Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.19826086
21Other glycan degradation_Homo sapiens_hsa005111.19788208
22GnRH signaling pathway_Homo sapiens_hsa049121.19447818
23Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.17720177
24Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.16946382
25Non-small cell lung cancer_Homo sapiens_hsa052231.16732178
26Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.16200337
27NF-kappa B signaling pathway_Homo sapiens_hsa040641.15584201
28Renal cell carcinoma_Homo sapiens_hsa052111.13786638
29mRNA surveillance pathway_Homo sapiens_hsa030151.13452995
30Estrogen signaling pathway_Homo sapiens_hsa049151.13384479
31Toll-like receptor signaling pathway_Homo sapiens_hsa046201.13105412
32Focal adhesion_Homo sapiens_hsa045101.12956696
33Oocyte meiosis_Homo sapiens_hsa041141.12011977
34Neurotrophin signaling pathway_Homo sapiens_hsa047221.11725289
35* ErbB signaling pathway_Homo sapiens_hsa040121.11715373
36Hippo signaling pathway_Homo sapiens_hsa043901.11391670
37Proteoglycans in cancer_Homo sapiens_hsa052051.09877097
38Phosphatidylinositol signaling system_Homo sapiens_hsa040701.09281021
39Choline metabolism in cancer_Homo sapiens_hsa052311.08498323
40PI3K-Akt signaling pathway_Homo sapiens_hsa041511.07962385
41Type II diabetes mellitus_Homo sapiens_hsa049301.07750811
42RNA transport_Homo sapiens_hsa030131.07415485
43Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.06023393
44Sphingolipid metabolism_Homo sapiens_hsa006001.04730100
45Small cell lung cancer_Homo sapiens_hsa052221.04651142
46Long-term depression_Homo sapiens_hsa047301.04137971
47Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.03585978
48VEGF signaling pathway_Homo sapiens_hsa043701.02451439
49Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.00901750
50Oxytocin signaling pathway_Homo sapiens_hsa049211.00366812
51p53 signaling pathway_Homo sapiens_hsa041151.00213034
52RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.99845933
53Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.99360216
54Prolactin signaling pathway_Homo sapiens_hsa049170.99316417
55Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.98675816
56MAPK signaling pathway_Homo sapiens_hsa040100.98628274
57African trypanosomiasis_Homo sapiens_hsa051430.98210753
58Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.97081428
59Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.95858216
60Nicotine addiction_Homo sapiens_hsa050330.95152863
61ECM-receptor interaction_Homo sapiens_hsa045120.94965674
62Regulation of actin cytoskeleton_Homo sapiens_hsa048100.94518432
63Pertussis_Homo sapiens_hsa051330.93948885
64Legionellosis_Homo sapiens_hsa051340.93735904
65Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.93698910
66Thyroid cancer_Homo sapiens_hsa052160.93669353
67AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.93097530
68Amphetamine addiction_Homo sapiens_hsa050310.92908436
69Wnt signaling pathway_Homo sapiens_hsa043100.91862818
70Dopaminergic synapse_Homo sapiens_hsa047280.91264602
71Lysine degradation_Homo sapiens_hsa003100.91079132
72Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.90487467
73Cholinergic synapse_Homo sapiens_hsa047250.90024254
74Aldosterone synthesis and secretion_Homo sapiens_hsa049250.89852226
75Glutamatergic synapse_Homo sapiens_hsa047240.89593151
76B cell receptor signaling pathway_Homo sapiens_hsa046620.89547401
77Circadian entrainment_Homo sapiens_hsa047130.88989519
78FoxO signaling pathway_Homo sapiens_hsa040680.88498384
79Prion diseases_Homo sapiens_hsa050200.88267600
80Rap1 signaling pathway_Homo sapiens_hsa040150.87608996
81Rheumatoid arthritis_Homo sapiens_hsa053230.85878878
82Fanconi anemia pathway_Homo sapiens_hsa034600.84573243
83Dilated cardiomyopathy_Homo sapiens_hsa054140.84552425
84Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.84101949
85Phospholipase D signaling pathway_Homo sapiens_hsa040720.84071436
86Prostate cancer_Homo sapiens_hsa052150.83749116
87Toxoplasmosis_Homo sapiens_hsa051450.83201078
88HTLV-I infection_Homo sapiens_hsa051660.82470747
89Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.82039533
90Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.81558847
91cAMP signaling pathway_Homo sapiens_hsa040240.81273777
92Gap junction_Homo sapiens_hsa045400.81139225
93Longevity regulating pathway - mammal_Homo sapiens_hsa042110.80870629
94Bladder cancer_Homo sapiens_hsa052190.80759607
95Axon guidance_Homo sapiens_hsa043600.79454040
96Hepatitis B_Homo sapiens_hsa051610.79453592
97Hedgehog signaling pathway_Homo sapiens_hsa043400.78571769
98Osteoclast differentiation_Homo sapiens_hsa043800.78148646
99Selenocompound metabolism_Homo sapiens_hsa004500.77619099
100Transcriptional misregulation in cancer_Homo sapiens_hsa052020.77058475
101Olfactory transduction_Homo sapiens_hsa047400.76971529
102Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.76889780
103Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.76340566
104Viral carcinogenesis_Homo sapiens_hsa052030.75890205
105Melanogenesis_Homo sapiens_hsa049160.75739477
106Melanoma_Homo sapiens_hsa052180.75687046
107RNA degradation_Homo sapiens_hsa030180.74613862
108Tight junction_Homo sapiens_hsa045300.74528440
109Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.74512288
110Basal cell carcinoma_Homo sapiens_hsa052170.74258076
111Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.74028397
112Shigellosis_Homo sapiens_hsa051310.73651797
113Platelet activation_Homo sapiens_hsa046110.73346545
114Central carbon metabolism in cancer_Homo sapiens_hsa052300.73126781
115cGMP-PKG signaling pathway_Homo sapiens_hsa040220.72801345
116Pathways in cancer_Homo sapiens_hsa052000.72551429
117Inositol phosphate metabolism_Homo sapiens_hsa005620.72427491
118Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.70749856
119Notch signaling pathway_Homo sapiens_hsa043300.70641490
120Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.70269933
121Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.69591563
122Adipocytokine signaling pathway_Homo sapiens_hsa049200.68842592
123Apoptosis_Homo sapiens_hsa042100.68530654
124Morphine addiction_Homo sapiens_hsa050320.68218768
125Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.68027542
126Circadian rhythm_Homo sapiens_hsa047100.67920920
127HIF-1 signaling pathway_Homo sapiens_hsa040660.67793993
128* Ras signaling pathway_Homo sapiens_hsa040140.66708841
129TNF signaling pathway_Homo sapiens_hsa046680.66451467
130Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.65551625
131Gastric acid secretion_Homo sapiens_hsa049710.64859738
132Endocytosis_Homo sapiens_hsa041440.64741332
133Acute myeloid leukemia_Homo sapiens_hsa052210.64480134
134Salivary secretion_Homo sapiens_hsa049700.63749944
135Insulin resistance_Homo sapiens_hsa049310.62470218
136Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.62446947
137Hepatitis C_Homo sapiens_hsa051600.59046981
138Influenza A_Homo sapiens_hsa051640.57999611
139Phagosome_Homo sapiens_hsa041450.57463633
140Sphingolipid signaling pathway_Homo sapiens_hsa040710.56065674
141Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.55330965
142Jak-STAT signaling pathway_Homo sapiens_hsa046300.55223092
143Vascular smooth muscle contraction_Homo sapiens_hsa042700.52375349
144Vibrio cholerae infection_Homo sapiens_hsa051100.50834911

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