ABLIM1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a cytoskeletal LIM protein that binds to actin filaments via a domain that is homologous to erythrocyte dematin. LIM domains, found in over 60 proteins, play key roles in the regulation of developmental pathways. LIM domains also function as protein-binding interfaces, mediating specific protein-protein interactions. The protein encoded by this gene could mediate such interactions between actin filaments and cytoplasmic targets. Alternatively spliced transcript variants encoding different isoforms have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)6.22008674
2positive thymic T cell selection (GO:0045059)6.04940319
3positive T cell selection (GO:0043368)5.87255451
4regulation of gamma-delta T cell differentiation (GO:0045586)5.82742943
5negative T cell selection (GO:0043383)5.77131821
6negative regulation of cell killing (GO:0031342)5.54008209
7negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.54008209
8thymic T cell selection (GO:0045061)5.39786014
9negative thymic T cell selection (GO:0045060)5.37080796
10T cell selection (GO:0045058)5.30508662
11regulation of gamma-delta T cell activation (GO:0046643)5.18136526
12antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.11562613
13antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.11562613
14antigen processing and presentation of endogenous antigen (GO:0019883)4.82793026
15membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.62029534
16response to interleukin-15 (GO:0070672)4.60674729
17positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.53011612
18detection of calcium ion (GO:0005513)4.43497198
19regulation of isotype switching to IgG isotypes (GO:0048302)4.23735664
20regulation of T cell tolerance induction (GO:0002664)4.20116757
21cellular response to interleukin-15 (GO:0071350)4.11075873
22negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.06166479
23regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.95438139
24sarcomere organization (GO:0045214)3.93232154
25interferon-gamma production (GO:0032609)3.88193683
26T cell receptor signaling pathway (GO:0050852)3.84354883
27cardiac conduction (GO:0061337)3.81364313
28cellular sodium ion homeostasis (GO:0006883)3.78402318
29T cell costimulation (GO:0031295)3.71859221
30relaxation of cardiac muscle (GO:0055119)3.70455155
31synaptic vesicle docking involved in exocytosis (GO:0016081)3.69540477
32positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.69120332
33lymphocyte costimulation (GO:0031294)3.64592667
34cardiac myofibril assembly (GO:0055003)3.63489674
35negative regulation of potassium ion transmembrane transport (GO:1901380)3.61747503
36regulation of relaxation of muscle (GO:1901077)3.61700940
37muscle hypertrophy (GO:0014896)3.57731836
38cardiac muscle cell action potential (GO:0086001)3.50709882
39cardiac muscle cell action potential involved in contraction (GO:0086002)3.49064152
40antigen receptor-mediated signaling pathway (GO:0050851)3.46970739
41cardiac muscle adaptation (GO:0014887)3.42908841
42cardiac muscle hypertrophy in response to stress (GO:0014898)3.42908841
43muscle hypertrophy in response to stress (GO:0003299)3.42908841
44positive regulation of tolerance induction (GO:0002645)3.42577063
45regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.40171469
46oxygen transport (GO:0015671)3.37921986
47cardiac muscle contraction (GO:0060048)3.37671439
48regulation of interleukin-12 biosynthetic process (GO:0045075)3.37484875
49cellular response to epinephrine stimulus (GO:0071872)3.37185129
50regulation of regulatory T cell differentiation (GO:0045589)3.36854078
51activated T cell proliferation (GO:0050798)3.36389339
52regulation of heart rate by cardiac conduction (GO:0086091)3.33107986
53regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.29277510
54glutamate secretion (GO:0014047)3.28134239
55regulation of heart rate (GO:0002027)3.25968856
56B cell receptor signaling pathway (GO:0050853)3.24162989
57plasma membrane repair (GO:0001778)3.23576554
58ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.23385009
59T cell migration (GO:0072678)3.22943177
60response to epinephrine (GO:0071871)3.21545114
61regulation of B cell receptor signaling pathway (GO:0050855)3.20706766
62regulation of membrane repolarization (GO:0060306)3.17479808
63activation of protein kinase A activity (GO:0034199)3.16736460
64cerebellar granule cell differentiation (GO:0021707)3.16536392
65regulation of actin filament-based movement (GO:1903115)3.14187521
66cardiac muscle tissue morphogenesis (GO:0055008)3.12765004
67potassium ion import (GO:0010107)3.09915569
68regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.09203908
69positive regulation of histone deacetylation (GO:0031065)3.08199392
70regulation of the force of heart contraction (GO:0002026)3.06522112
71synaptic vesicle maturation (GO:0016188)3.06004365
72myofibril assembly (GO:0030239)3.03962648
73cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.02749137
74sodium ion export (GO:0071436)3.02654143
75neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.00128521
76potassium ion homeostasis (GO:0055075)2.97330304
77regulation of cell communication by electrical coupling (GO:0010649)2.96250002
78negative regulation of T cell mediated immunity (GO:0002710)2.95088319
79positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.94213737
80cytoskeletal anchoring at plasma membrane (GO:0007016)2.92619502
81regulation of cardioblast differentiation (GO:0051890)2.92169783
82regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.90163238
83regulation of cardiac muscle contraction (GO:0055117)2.89614876
84desmosome organization (GO:0002934)2.89441931
85lymph vessel development (GO:0001945)2.88494123
86cell communication involved in cardiac conduction (GO:0086065)2.86924471
87regulation of synaptic vesicle exocytosis (GO:2000300)2.84993087
88positive regulation of interleukin-2 production (GO:0032743)2.84714935
89regulation of calcium ion transmembrane transporter activity (GO:1901019)2.84073030
90regulation of calcium ion transmembrane transport (GO:1903169)2.84073030
91tolerance induction (GO:0002507)2.83422746
92regulation of tolerance induction (GO:0002643)2.80808796
93positive regulation of sodium ion transport (GO:0010765)2.80680195
94regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.78769974
95regulation of heart contraction (GO:0008016)2.77750255
96positive regulation of Rap GTPase activity (GO:0032854)2.76271688
97sarcoplasmic reticulum calcium ion transport (GO:0070296)2.72912731
98cellular response to zinc ion (GO:0071294)2.72738879
99leukocyte aggregation (GO:0070486)2.71905012
100regulation of cardiac muscle cell contraction (GO:0086004)2.70964202
101regulation of voltage-gated calcium channel activity (GO:1901385)2.70787235
102regulation of sodium ion transmembrane transport (GO:1902305)2.69733808
103muscle tissue morphogenesis (GO:0060415)2.68815084
104cellular response to catecholamine stimulus (GO:0071870)2.68798436
105cellular response to monoamine stimulus (GO:0071868)2.68798436
106regulation of sarcomere organization (GO:0060297)2.68508474
107muscle filament sliding (GO:0030049)2.68361673
108actin-myosin filament sliding (GO:0033275)2.68361673
109synaptic vesicle exocytosis (GO:0016079)2.66861026
110morphogenesis of an endothelium (GO:0003159)2.66680262
111endothelial tube morphogenesis (GO:0061154)2.66680262
112relaxation of muscle (GO:0090075)2.64885097
113heart trabecula formation (GO:0060347)2.63823044
114vascular endothelial growth factor signaling pathway (GO:0038084)2.63672352
115actomyosin structure organization (GO:0031032)2.62636158
116protein localization to endosome (GO:0036010)2.62621736
117regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.62341095
118positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.61605957
119regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.61431297
120keratinization (GO:0031424)2.59824093
121response to monoamine (GO:0071867)2.59800621
122response to catecholamine (GO:0071869)2.59800621
123cardiac muscle hypertrophy (GO:0003300)2.58887751
124regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.58365147
125negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.56810750
126regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.56508540
127positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.55868783
128multicellular organismal signaling (GO:0035637)2.54505593
129immune response-activating cell surface receptor signaling pathway (GO:0002429)2.52602634
130ventricular cardiac muscle cell action potential (GO:0086005)2.52242983
131striated muscle contraction (GO:0006941)2.51979237
132alpha-beta T cell differentiation (GO:0046632)2.51792389
133regulation of sodium ion transmembrane transporter activity (GO:2000649)2.51581547
134cell communication by electrical coupling (GO:0010644)2.50311655
135neurotransmitter secretion (GO:0007269)2.50277298
136negative regulation of potassium ion transport (GO:0043267)2.49371685
137positive regulation of synapse maturation (GO:0090129)2.49178988
138response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.49029320
139adult heart development (GO:0007512)2.48968250
140regulation of T cell receptor signaling pathway (GO:0050856)2.48730932
141striated muscle hypertrophy (GO:0014897)2.48143437
142sodium ion homeostasis (GO:0055078)2.48053658
143V(D)J recombination (GO:0033151)2.46591170
144alpha-beta T cell activation (GO:0046631)2.46458282
145regulation of alpha-beta T cell proliferation (GO:0046640)2.46393216
146T cell differentiation (GO:0030217)2.46299011
147regulation of sodium ion transport (GO:0002028)2.46072231
148actin-mediated cell contraction (GO:0070252)2.46069980
149regulation of short-term neuronal synaptic plasticity (GO:0048172)2.45623359
150regulation of synaptic vesicle transport (GO:1902803)2.43349439
151NADH metabolic process (GO:0006734)2.42726970
152positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.42226691
153cellular potassium ion homeostasis (GO:0030007)2.41513647
154cardiac muscle cell development (GO:0055013)2.41177412
155regulation of ARF protein signal transduction (GO:0032012)2.40448637
156bundle of His cell to Purkinje myocyte communication (GO:0086069)2.40026757
157regulation of interleukin-2 biosynthetic process (GO:0045076)2.37989292
158carnitine shuttle (GO:0006853)2.37927131
159regulation of striated muscle contraction (GO:0006942)2.37469470
160JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.36676105
161regulation of B cell differentiation (GO:0045577)2.36145904

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse6.09474790
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.64808419
3RUNX_20019798_ChIP-Seq_JUKART_Human3.71096175
4MYC_22102868_ChIP-Seq_BL_Human2.98991991
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.96149149
6FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.92331249
7* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.54924797
8CDX2_19796622_ChIP-Seq_MESCs_Mouse2.45404704
9STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.44429063
10KDM2B_26808549_Chip-Seq_DND41_Human2.38142107
11MAF_26560356_Chip-Seq_TH1_Human2.22998305
12IRF8_22096565_ChIP-ChIP_GC-B_Human2.22157805
13SMAD_19615063_ChIP-ChIP_OVARY_Human2.15839380
14* KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.12534179
15TCF7_22412390_ChIP-Seq_EML_Mouse2.09111484
16* UTX_26944678_Chip-Seq_JUKART_Human2.07735164
17MYB_26560356_Chip-Seq_TH2_Human2.06457276
18IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.05461145
19KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.87990341
20E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.80593668
21* KDM2B_26808549_Chip-Seq_JURKAT_Human1.79485644
22VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.72827298
23MYB_26560356_Chip-Seq_TH1_Human1.72320071
24DROSHA_22980978_ChIP-Seq_HELA_Human1.70467347
25* TBX20_22080862_ChIP-Seq_HEART_Mouse1.70006893
26* TBX20_22328084_ChIP-Seq_HEART_Mouse1.70006893
27SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.68744655
28GATA3_27048872_Chip-Seq_THYMUS_Human1.62045171
29THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.60400236
30* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.59667434
31VDR_21846776_ChIP-Seq_THP-1_Human1.59515220
32ESR1_20079471_ChIP-ChIP_T-47D_Human1.58215617
33PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.56280097
34GBX2_23144817_ChIP-Seq_PC3_Human1.53877661
35FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.49497070
36EZH2_22144423_ChIP-Seq_EOC_Human1.48446002
37SPI1_23127762_ChIP-Seq_K562_Human1.46093899
38SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.44826887
39ELK3_25401928_ChIP-Seq_HUVEC_Human1.44543130
40PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.43835880
41AR_21572438_ChIP-Seq_LNCaP_Human1.43427323
42* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.43134292
43MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.42347357
44STAT4_19710469_ChIP-ChIP_TH1__Mouse1.42258277
45TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.42147267
46* NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.40073712
47EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.38922736
48SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.38519688
49JARID2_20064375_ChIP-Seq_MESCs_Mouse1.38254189
50KDM2B_26808549_Chip-Seq_K562_Human1.38132889
51GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.35537513
52IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.33399938
53TRIM28_21343339_ChIP-Seq_HEK293_Human1.32578861
54* EP300_21415370_ChIP-Seq_HL-1_Mouse1.32014796
55MAF_26560356_Chip-Seq_TH2_Human1.31819016
56RNF2_27304074_Chip-Seq_ESCs_Mouse1.31003695
57GATA1_19941826_ChIP-Seq_K562_Human1.30993700
58* FOXA2_19822575_ChIP-Seq_HepG2_Human1.29739274
59SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.29470969
60* GATA2_21666600_ChIP-Seq_HMVEC_Human1.29037773
61TP63_17297297_ChIP-ChIP_HaCaT_Human1.28363180
62SMAD4_21799915_ChIP-Seq_A2780_Human1.26959825
63JARID2_20075857_ChIP-Seq_MESCs_Mouse1.25630628
64GATA1_22025678_ChIP-Seq_K562_Human1.23790244
65LXR_22292898_ChIP-Seq_THP-1_Human1.23194172
66PIAS1_25552417_ChIP-Seq_VCAP_Human1.22747487
67EZH2_27294783_Chip-Seq_ESCs_Mouse1.22366396
68* FOXO3_23340844_ChIP-Seq_DLD1_Human1.21200214
69* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.21103065
70TCF4_18268006_ChIP-ChIP_LS174T_Human1.20023554
71CLOCK_20551151_ChIP-Seq_293T_Human1.19596008
72* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.18899840
73STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.18499582
74ZNF263_19887448_ChIP-Seq_K562_Human1.17474341
75TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.16928621
76ESR2_21235772_ChIP-Seq_MCF-7_Human1.16836814
77GATA2_19941826_ChIP-Seq_K562_Human1.13957486
78* RUNX1_27514584_Chip-Seq_MCF-7_Human1.13792008
79* RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.13384829
80YAP1_20516196_ChIP-Seq_MESCs_Mouse1.12904074
81AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.11481395
82VDR_24763502_ChIP-Seq_THP-1_Human1.10842072
83SCL_19346495_ChIP-Seq_HPC-7_Human1.10390726
84REST_21632747_ChIP-Seq_MESCs_Mouse1.09596250
85SMAD3_21741376_ChIP-Seq_HESCs_Human1.08549975
86EZH2_27304074_Chip-Seq_ESCs_Mouse1.08029055
87ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.07895021
88WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.07369765
89SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07354408
90EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.07204200
91CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.05783993
92SUZ12_27294783_Chip-Seq_ESCs_Mouse1.05686341
93ESR1_21235772_ChIP-Seq_MCF-7_Human1.05482019
94* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.05133824
95BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.04305284
96GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.03852284
97KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.03290379
98* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.02949961
99RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02589054
100CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.01822304
101MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.01771911
102PPAR_26484153_Chip-Seq_NCI-H1993_Human1.01622530
103IKZF1_21737484_ChIP-ChIP_HCT116_Human1.01502054
104BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.01426493
105AHR_22903824_ChIP-Seq_MCF-7_Human1.01127201
106* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.00504250
107EGR1_19374776_ChIP-ChIP_THP-1_Human0.99627945
108SOX2_21211035_ChIP-Seq_LN229_Gbm0.98761863
109* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.98735297
110SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.98491608
111* LXR_22158963_ChIP-Seq_LIVER_Mouse0.98482729
112* ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.97875970
113OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.97196999
114RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.97039142
115AR_19668381_ChIP-Seq_PC3_Human0.95644610
116SOX2_27498859_Chip-Seq_STOMACH_Mouse0.95238115
117* CTNNB1_20460455_ChIP-Seq_HCT116_Human0.94920914
118* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.94872996
119ZFP281_27345836_Chip-Seq_ESCs_Mouse0.93592219
120ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.93339306
121SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.93275789
122ISL1_27105846_Chip-Seq_CPCs_Mouse0.92847912
123REST_18959480_ChIP-ChIP_MESCs_Mouse0.91807724
124SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.91273390
125RXR_22108803_ChIP-Seq_LS180_Human0.90991015
126* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90803337
127RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.90626907
128* SMAD4_21741376_ChIP-Seq_HESCs_Human0.90492925
129TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.90059745
130* GATA1_19941827_ChIP-Seq_MEL_Mouse0.90022098
131RARB_27405468_Chip-Seq_BRAIN_Mouse0.89804165
132PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.89379296
133CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.88993057
134ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.88683911
135TAF15_26573619_Chip-Seq_HEK293_Human0.87978612
136P300_27058665_Chip-Seq_ZR-75-30cells_Human0.87459615
137TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.86045433
138* TP63_23658742_ChIP-Seq_EP156T_Human0.85750661
139TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.85633009
140RUNX1_22412390_ChIP-Seq_EML_Mouse0.85314146
141TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.84306397
142NRF2_20460467_ChIP-Seq_MEFs_Mouse0.84062924
143NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.84062924
144* NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.83951628
145MTF2_20144788_ChIP-Seq_MESCs_Mouse0.83887419
146RING1B_27294783_Chip-Seq_ESCs_Mouse0.83887314
147SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.83789112
148BCAT_22108803_ChIP-Seq_LS180_Human0.83446107
149SALL4_18804426_ChIP-ChIP_XEN_Mouse0.83130187
150NR3C1_23031785_ChIP-Seq_PC12_Mouse0.82645570
151* RACK7_27058665_Chip-Seq_MCF-7_Human0.82602158
152ARNT_22903824_ChIP-Seq_MCF-7_Human0.82390553
153EZH2_18974828_ChIP-Seq_MESCs_Mouse0.80525260
154RNF2_18974828_ChIP-Seq_MESCs_Mouse0.80525260
155VDR_24787735_ChIP-Seq_THP-1_Human0.79813398
156ZFP281_18757296_ChIP-ChIP_E14_Mouse0.79507827
157SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.78841069
158STAT6_21828071_ChIP-Seq_BEAS2B_Human0.77808882

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology3.99060670
2MP0004084_abnormal_cardiac_muscle3.51556592
3MP0002837_dystrophic_cardiac_calcinosis3.43601534
4MP0004215_abnormal_myocardial_fiber3.02034162
5MP0009780_abnormal_chondrocyte_physiolo2.93974358
6MP0000751_myopathy2.92232999
7MP0004270_analgesia2.73974252
8MP0002166_altered_tumor_susceptibility2.68009387
9MP0003646_muscle_fatigue2.57435168
10MP0005671_abnormal_response_to2.54988590
11MP0004036_abnormal_muscle_relaxation2.51436297
12MP0004510_myositis2.48070383
13MP0005409_darkened_coat_color2.45010173
14MP0003300_gastrointestinal_ulcer2.37411141
15MP0000579_abnormal_nail_morphology2.37374143
16MP0005330_cardiomyopathy2.33558721
17MP0004130_abnormal_muscle_cell2.27032623
18MP0005423_abnormal_somatic_nervous2.26319820
19MP0004484_altered_response_of2.16327202
20MP0000685_abnormal_immune_system2.15837813
21MP0001873_stomach_inflammation2.15016183
22MP0001800_abnormal_humoral_immune2.14576451
23MP0001790_abnormal_immune_system2.10689989
24MP0005387_immune_system_phenotype2.10689989
25MP0008961_abnormal_basal_metabolism2.09389704
26MP0004087_abnormal_muscle_fiber1.97493081
27MP0003828_pulmonary_edema1.96222833
28MP0002972_abnormal_cardiac_muscle1.89526856
29MP0003635_abnormal_synaptic_transmissio1.89292646
30MP0001879_abnormal_lymphatic_vessel1.87956703
31MP0003880_abnormal_central_pattern1.86433467
32MP0010630_abnormal_cardiac_muscle1.85879691
33MP0000703_abnormal_thymus_morphology1.85433642
34MP0002006_tumorigenesis1.85109462
35MP0000749_muscle_degeneration1.74455475
36MP0002064_seizures1.74108463
37MP0008569_lethality_at_weaning1.73383481
38MP0003690_abnormal_glial_cell1.72582847
39MP0005385_cardiovascular_system_phenoty1.67888417
40MP0001544_abnormal_cardiovascular_syste1.67888417
41MP0002398_abnormal_bone_marrow1.67517293
42MP0003045_fibrosis1.64140897
43MP0010368_abnormal_lymphatic_system1.61184216
44MP0008775_abnormal_heart_ventricle1.60956469
45MP0002420_abnormal_adaptive_immunity1.60180612
46MP0010234_abnormal_vibrissa_follicle1.57759822
47MP0004947_skin_inflammation1.56404889
48MP0001819_abnormal_immune_cell1.54395049
49MP0001501_abnormal_sleep_pattern1.52403609
50MP0003866_abnormal_defecation1.51625139
51MP0001835_abnormal_antigen_presentation1.51519060
52MP0005620_abnormal_muscle_contractility1.50847913
53MP0002063_abnormal_learning/memory/cond1.50356472
54MP0002272_abnormal_nervous_system1.49437456
55MP0009745_abnormal_behavioral_response1.48777833
56MP0003329_amyloid_beta_deposits1.48448099
57MP0004185_abnormal_adipocyte_glucose1.43119962
58MP0002723_abnormal_immune_serum1.42632769
59MP0002127_abnormal_cardiovascular_syste1.42441489
60MP0002452_abnormal_antigen_presenting1.40369134
61MP0000716_abnormal_immune_system1.39278301
62MP0009046_muscle_twitch1.39098582
63MP0005666_abnormal_adipose_tissue1.38786834
64MP0001486_abnormal_startle_reflex1.38775675
65MP0006138_congestive_heart_failure1.38242978
66MP0005670_abnormal_white_adipose1.37771059
67MP0003303_peritoneal_inflammation1.37666063
68MP0004085_abnormal_heartbeat1.36745798
69MP0005275_abnormal_skin_tensile1.34898027
70MP0004885_abnormal_endolymph1.34368791
71MP0002722_abnormal_immune_system1.31300952
72MP0002106_abnormal_muscle_physiology1.31188196
73MP0002822_catalepsy1.30979930
74MP0005000_abnormal_immune_tolerance1.30541491
75MP0002009_preneoplasia1.29071720
76MP0001984_abnormal_olfaction1.28849792
77MP0003879_abnormal_hair_cell1.25895375
78MP0000566_synostosis1.25689237
79MP0009278_abnormal_bone_marrow1.25620180
80MP0010155_abnormal_intestine_physiology1.24400535
81MP0004043_abnormal_pH_regulation1.22044500
82MP0000747_muscle_weakness1.20059720
83MP0002405_respiratory_system_inflammati1.17927799
84MP0000689_abnormal_spleen_morphology1.17472517
85MP0003137_abnormal_impulse_conducting1.16707579
86MP0005375_adipose_tissue_phenotype1.15828039
87MP0000013_abnormal_adipose_tissue1.15747528
88MP0002734_abnormal_mechanical_nocicepti1.15703570
89MP0004145_abnormal_muscle_electrophysio1.14819251
90MP0000750_abnormal_muscle_regeneration1.13722802
91MP0005167_abnormal_blood-brain_barrier1.13010933
92MP0000759_abnormal_skeletal_muscle1.11238738
93MP0001502_abnormal_circadian_rhythm1.10988713
94MP0003279_aneurysm1.08866302
95MP0002796_impaired_skin_barrier1.08463399
96MP0002572_abnormal_emotion/affect_behav1.06435489
97MP0002933_joint_inflammation1.05765479
98MP0002429_abnormal_blood_cell1.04156270
99MP0004808_abnormal_hematopoietic_stem1.02918057
100MP0009333_abnormal_splenocyte_physiolog1.01589442
101MP0000003_abnormal_adipose_tissue1.00085656
102MP0005369_muscle_phenotype0.97853416
103MP0002269_muscular_atrophy0.96751581
104MP0010678_abnormal_skin_adnexa0.96507767
105MP0002909_abnormal_adrenal_gland0.96199642
106MP0003221_abnormal_cardiomyocyte_apopto0.92550595
107MP0000920_abnormal_myelination0.92500016
108MP0003633_abnormal_nervous_system0.91553881
109MP0003724_increased_susceptibility_to0.90800743
110MP0001851_eye_inflammation0.90480530
111MP0003566_abnormal_cell_adhesion0.88894269
112MP0002638_abnormal_pupillary_reflex0.87754349
113MP0003453_abnormal_keratinocyte_physiol0.86807147
114MP0005535_abnormal_body_temperature0.85597490
115MP0003950_abnormal_plasma_membrane0.85370681
116MP0001765_abnormal_ion_homeostasis0.83431630
117MP0002396_abnormal_hematopoietic_system0.83207987
118MP0008874_decreased_physiological_sensi0.83072585
119MP0000266_abnormal_heart_morphology0.82136553
120MP0002971_abnormal_brown_adipose0.81623995
121MP0005025_abnormal_response_to0.81369245
122MP0004859_abnormal_synaptic_plasticity0.80935697
123MP0003091_abnormal_cell_migration0.79842718
124MP0001440_abnormal_grooming_behavior0.78112847
125MP0001784_abnormal_fluid_regulation0.77141357
126MP0004924_abnormal_behavior0.77138323
127MP0005386_behavior/neurological_phenoty0.77138323
128MP0002332_abnormal_exercise_endurance0.76135258
129MP0002128_abnormal_blood_circulation0.75582141
130MP0003705_abnormal_hypodermis_morpholog0.75319318
131MP0009785_altered_susceptibility_to0.74204088
132MP0008004_abnormal_stomach_pH0.73968180
133MP0003631_nervous_system_phenotype0.72778445
134MP0001970_abnormal_pain_threshold0.71544313
135MP0010329_abnormal_lipoprotein_level0.71120902
136MP0002067_abnormal_sensory_capabilities0.70901788
137MP0002735_abnormal_chemical_nociception0.70710617
138MP0001845_abnormal_inflammatory_respons0.70123868
139MP0001853_heart_inflammation0.69971117
140MP0005623_abnormal_meninges_morphology0.69310999
141MP0005165_increased_susceptibility_to0.68260811
142MP0004233_abnormal_muscle_weight0.67928024
143MP0003787_abnormal_imprinting0.67917466
144MP0002066_abnormal_motor_capabilities/c0.65670699
145MP0003634_abnormal_glial_cell0.65557462
146MP0003122_maternal_imprinting0.65471323
147MP0001348_abnormal_lacrimal_gland0.64869288
148MP0004381_abnormal_hair_follicle0.62181910
149MP0002078_abnormal_glucose_homeostasis0.58213169
150MP0005501_abnormal_skin_physiology0.57220784
151MP0001756_abnormal_urination0.57095680

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)5.05163036
2Sudden death (HP:0001699)5.04797593
3Abnormality of T cell number (HP:0011839)4.80154173
4Ventricular tachycardia (HP:0004756)4.23107679
5Hyporeflexia of lower limbs (HP:0002600)3.94119201
6Exercise-induced myalgia (HP:0003738)3.83433327
7Recurrent bronchitis (HP:0002837)3.73676204
8Verrucae (HP:0200043)3.71523451
9Papilloma (HP:0012740)3.71523451
10Atrial fibrillation (HP:0005110)3.69253182
11Myokymia (HP:0002411)3.61546565
12Panhypogammaglobulinemia (HP:0003139)3.58716588
13Agammaglobulinemia (HP:0004432)3.53266657
14Primary atrial arrhythmia (HP:0001692)3.48298969
15Right ventricular cardiomyopathy (HP:0011663)3.44688263
16Calf muscle hypertrophy (HP:0008981)3.40637584
17Dysmetric saccades (HP:0000641)3.36666299
18Supraventricular tachycardia (HP:0004755)3.33796663
19Supraventricular arrhythmia (HP:0005115)3.31502817
20Severe combined immunodeficiency (HP:0004430)3.24982428
21Muscle fiber splitting (HP:0003555)3.19915386
22Bundle branch block (HP:0011710)3.15315191
23Thyroiditis (HP:0100646)3.10906195
24EMG: neuropathic changes (HP:0003445)3.08850210
25Abnormality of the fingertips (HP:0001211)3.07959881
26Syncope (HP:0001279)3.07632325
27Recurrent viral infections (HP:0004429)3.06883018
28Exercise-induced muscle cramps (HP:0003710)3.06010874
29Difficulty running (HP:0009046)3.05759460
30Ventricular fibrillation (HP:0001663)3.02670543
31Combined immunodeficiency (HP:0005387)3.02362918
32Muscle hypertrophy of the lower extremities (HP:0008968)3.02161561
33Abnormality of the nasal mucosa (HP:0000433)2.99493821
34Abnormality of T cells (HP:0002843)2.99153661
35Lipoatrophy (HP:0100578)2.95095901
36B lymphocytopenia (HP:0010976)2.93347132
37Abnormality of B cell number (HP:0010975)2.93347132
38Nasal polyposis (HP:0100582)2.89329030
39Action tremor (HP:0002345)2.85441379
40Increased connective tissue (HP:0009025)2.83976380
41Abnormality of the calf musculature (HP:0001430)2.82166093
42Prolonged QT interval (HP:0001657)2.79019593
43Myotonia (HP:0002486)2.78199692
44Atonic seizures (HP:0010819)2.75712613
45Febrile seizures (HP:0002373)2.74791194
46Abnormality of the left ventricular outflow tract (HP:0011103)2.74491027
47Subaortic stenosis (HP:0001682)2.74491027
48Chronic otitis media (HP:0000389)2.73779905
49Obstructive sleep apnea (HP:0002870)2.68094922
50Colitis (HP:0002583)2.66768211
51Focal motor seizures (HP:0011153)2.61026680
52Abnormal delayed hypersensitivity skin test (HP:0002963)2.58873121
53Facial diplegia (HP:0001349)2.57190862
54EMG: myopathic abnormalities (HP:0003458)2.54400282
55Abnormality of the foot musculature (HP:0001436)2.52763803
56Palmoplantar keratoderma (HP:0000982)2.50951044
57Inflammation of the large intestine (HP:0002037)2.50705311
58Myoglobinuria (HP:0002913)2.48793469
59Ventricular arrhythmia (HP:0004308)2.42017899
60Gastrointestinal inflammation (HP:0004386)2.41158444
61Hemiplegia (HP:0002301)2.40165001
62Gastrointestinal stroma tumor (HP:0100723)2.39397433
63Chronic sinusitis (HP:0011109)2.38089499
64Abnormality of nail color (HP:0100643)2.38070224
65Papilledema (HP:0001085)2.37892619
66Vertebral arch anomaly (HP:0008438)2.36813611
67Recurrent fungal infections (HP:0002841)2.36758158
68Foot dorsiflexor weakness (HP:0009027)2.33613870
69Abnormality of the salivary glands (HP:0010286)2.33092124
70Broad metatarsal (HP:0001783)2.33016404
71Increased IgE level (HP:0003212)2.31966832
72Heart block (HP:0012722)2.31200054
73Atrioventricular block (HP:0001678)2.31083961
74Dilated cardiomyopathy (HP:0001644)2.30334132
75Frequent falls (HP:0002359)2.24646519
76Spontaneous hematomas (HP:0007420)2.23629089
77Abnormality of skeletal muscle fiber size (HP:0012084)2.21993042
78Centrally nucleated skeletal muscle fibers (HP:0003687)2.21538688
79Increased variability in muscle fiber diameter (HP:0003557)2.20153125
80Recurrent sinusitis (HP:0011108)2.18277948
81Eosinophilia (HP:0001880)2.16723957
82Abnormal atrioventricular conduction (HP:0005150)2.16577477
83Conjunctival hamartoma (HP:0100780)2.15220704
84Ankle clonus (HP:0011448)2.13087525
85IgG deficiency (HP:0004315)2.12411363
86Cerebral aneurysm (HP:0004944)2.10882180
87Growth hormone excess (HP:0000845)2.10063730
88Abnormality of eosinophils (HP:0001879)2.09122254
89Focal seizures (HP:0007359)2.08821846
90Supranuclear gaze palsy (HP:0000605)2.08726934
91Aortic aneurysm (HP:0004942)2.06807690
92Muscle stiffness (HP:0003552)2.06527676
93Lymphopenia (HP:0001888)2.05819206
94Neck muscle weakness (HP:0000467)2.05534335
95Emphysema (HP:0002097)2.04587701
96Asymmetric septal hypertrophy (HP:0001670)2.04150071
97Increased circulating renin level (HP:0000848)2.03348768
98IgM deficiency (HP:0002850)2.02267045
99Hyperkalemia (HP:0002153)2.00390556
100Left ventricular hypertrophy (HP:0001712)1.98891095
101Postural instability (HP:0002172)1.98197416
102Bronchitis (HP:0012387)1.97030057
103Autoimmune thrombocytopenia (HP:0001973)1.96669979
104Chronic mucocutaneous candidiasis (HP:0002728)1.96069190
105Recurrent cutaneous fungal infections (HP:0011370)1.96069190
106Palmoplantar hyperkeratosis (HP:0000972)1.95324634
107Dysdiadochokinesis (HP:0002075)1.94944225
108Distal lower limb muscle weakness (HP:0009053)1.94074976
109Sudden cardiac death (HP:0001645)1.93386879
110Abnormality of cells of the lymphoid lineage (HP:0012140)1.93007421
111Bradycardia (HP:0001662)1.92755498
112Neurofibrillary tangles (HP:0002185)1.92082065
113Epileptic encephalopathy (HP:0200134)1.90141087
114Abnormal EKG (HP:0003115)1.89435221
115Dysmetria (HP:0001310)1.89143078
116Meningitis (HP:0001287)1.87015667
117Intention tremor (HP:0002080)1.86887527
118Plantar hyperkeratosis (HP:0007556)1.86350281
119Autoimmune hemolytic anemia (HP:0001890)1.86190348
120Aplasia involving bones of the upper limbs (HP:0009823)1.85894244
121Aplasia of the phalanges of the hand (HP:0009802)1.85894244
122Aplasia involving bones of the extremities (HP:0009825)1.85894244
123Scanning speech (HP:0002168)1.85202309
124Hamartoma of the eye (HP:0010568)1.84554762
125Hypoplasia of the thymus (HP:0000778)1.84385521
126Areflexia of lower limbs (HP:0002522)1.83505703
127Macroorchidism (HP:0000053)1.83342288
128Pustule (HP:0200039)1.82949957
129Recurrent otitis media (HP:0000403)1.82126613
130Hypotrichosis (HP:0001006)1.81661779
131Tetraplegia (HP:0002445)1.81659034
132Palmar hyperkeratosis (HP:0010765)1.80336230
133IgA deficiency (HP:0002720)1.79819558
134Palpitations (HP:0001962)1.78385638
135Cellulitis (HP:0100658)1.78284941
136Anxiety (HP:0000739)1.77784023
137Abnormality of binocular vision (HP:0011514)1.77586161
138Diplopia (HP:0000651)1.77586161
139Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.77294657
140Hematochezia (HP:0002573)1.74722349
141Truncal ataxia (HP:0002078)1.74366414
142Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.73746264
143Absence seizures (HP:0002121)1.71339296
144Depression (HP:0000716)1.71178715
145Arterial tortuosity (HP:0005116)1.68683223
146Hyperactive renin-angiotensin system (HP:0000841)1.68469060
147Resting tremor (HP:0002322)1.67682340
148Hypercortisolism (HP:0001578)1.66708694
149Congenital malformation of the right heart (HP:0011723)1.66689643
150Double outlet right ventricle (HP:0001719)1.66689643
151Menstrual irregularities (HP:0000858)1.66111072
152Skin nodule (HP:0200036)1.65192197
153Steppage gait (HP:0003376)1.64188402
154Milia (HP:0001056)1.62809176
155Cerebral inclusion bodies (HP:0100314)1.60576240
156Neonatal hypoglycemia (HP:0001998)1.60504583
157Adrenal overactivity (HP:0002717)1.60457731
158Rapidly progressive (HP:0003678)1.60285164
159Progressive cerebellar ataxia (HP:0002073)1.58776523
160Generalized tonic-clonic seizures (HP:0002069)1.56199578
161Hyperaldosteronism (HP:0000859)1.54206768

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.27350288
2TXK2.96449040
3TTN2.70336756
4TRIB32.55808157
5FGFR42.44962111
6MAP3K102.24225736
7PKN22.21122816
8NTRK32.19861411
9FGFR32.19103044
10EEF2K2.17982040
11MAP3K92.07731853
12UHMK12.00494319
13STK102.00220940
14GRK61.97736569
15PRKCH1.96058227
16JAK11.88077855
17PRPF4B1.87521381
18MARK11.84004826
19LMTK21.79516589
20JAK31.70483240
21DMPK1.67853222
22* ITK1.67373280
23MAPK121.66999702
24MAP3K71.66803316
25NLK1.66338516
26SGK2231.64126316
27SGK4941.64126316
28ZAP701.63414087
29TIE11.54939669
30TYK21.54616421
31RIPK11.54365577
32KDR1.51182895
33SIK21.48740047
34FGFR21.45302504
35EPHA41.43999050
36MAP3K21.41871324
37PHKG11.39310017
38PHKG21.39310017
39DAPK21.32658188
40LRRK21.30984969
41OBSCN1.27134040
42LATS21.23415749
43TGFBR21.23189848
44SYK1.21006520
45MAPK71.20210895
46MYLK1.15363050
47MARK21.14990362
48CSK1.14778074
49PAK61.13978602
50LCK1.12298685
51IKBKE1.07818484
52CAMK2D1.05131397
53PRKCQ1.02038810
54STK241.02033076
55KSR21.01447957
56MARK31.00789684
57HCK0.99740058
58NTRK10.98741434
59PRKD10.98558436
60CAMK1G0.98212175
61CAMK2B0.97621626
62FER0.96224101
63PTK60.95782689
64MAP3K120.94142669
65TYRO30.93486677
66CDK50.91561924
67WNK10.88570359
68PRKD30.88174338
69SGK30.87463275
70TAOK10.85860049
71NEK60.85785061
72PDK10.85626168
73EPHB10.83356439
74PDGFRB0.82813507
75PRKD20.82517195
76CAMK2A0.82329341
77TEC0.81726369
78MST40.80494743
79GRK50.80304217
80RET0.78736592
81JAK20.78078873
82NTRK20.76675804
83STK380.76597874
84SGK10.76012775
85SIK10.75596823
86PDK20.75184259
87MAP3K130.74947899
88STK38L0.74378447
89CDC42BPA0.74042768
90BTK0.73944125
91PDK30.73482858
92PDK40.73482858
93PDGFRA0.73120637
94PINK10.72337346
95CAMK1D0.70868308
96ICK0.70184027
97MAP3K60.69201277
98MST1R0.68814020
99ALK0.68091385
100PAK30.67922254
101MAP2K30.67397528
102MINK10.67167507
103PRKCE0.66922716
104MAP3K10.64889824
105MAPKAPK30.64867526
106CAMK40.64503481
107CASK0.64350736
108MAPK100.64289889
109EPHA30.63910115
110STK110.62631250
111MUSK0.62273570
112FGFR10.61845014
113ROCK10.61393876
114FES0.60785590
115STK390.58753054
116TNK20.56594309
117TRPM70.56564084
118HIPK20.56265113
119PRKAA20.56103702
120CAMK2G0.55475900
121PTK2B0.54893790
122INSRR0.51679327
123TBK10.51282759
124FYN0.50983146
125CAMK10.50443312
126LATS10.50267609
127SGK20.50138940
128ERN10.49453618
129MAP3K140.48070054
130GRK10.47062305
131AKT30.46205810
132ROCK20.45707283
133* RPS6KA30.45128423
134PTK20.44503381
135CAMKK20.44137114
136MET0.43992583
137MAPK40.42761080
138PIK3CA0.41961022
139CAMKK10.41624960
140PRKAA10.40949055
141MAPK110.40069606
142ILK0.39089148
143CDK120.38550954
144PDPK10.36851379

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.08689199
2T cell receptor signaling pathway_Homo sapiens_hsa046602.57679800
3Dilated cardiomyopathy_Homo sapiens_hsa054141.97575550
4Circadian rhythm_Homo sapiens_hsa047101.94027633
5B cell receptor signaling pathway_Homo sapiens_hsa046621.90300734
6Viral myocarditis_Homo sapiens_hsa054161.81067920
7Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.72262577
8Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.70161692
9Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.63531382
10Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.52497823
11GABAergic synapse_Homo sapiens_hsa047271.52056206
12Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.50922056
13Phosphatidylinositol signaling system_Homo sapiens_hsa040701.46443704
14Bile secretion_Homo sapiens_hsa049761.35589313
15Leukocyte transendothelial migration_Homo sapiens_hsa046701.34649797
16Gastric acid secretion_Homo sapiens_hsa049711.32376215
17Intestinal immune network for IgA production_Homo sapiens_hsa046721.31166173
18Aldosterone synthesis and secretion_Homo sapiens_hsa049251.29149274
19Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.28014005
20cGMP-PKG signaling pathway_Homo sapiens_hsa040221.27804606
21Nicotine addiction_Homo sapiens_hsa050331.26969178
22Osteoclast differentiation_Homo sapiens_hsa043801.26566905
23Long-term potentiation_Homo sapiens_hsa047201.26306980
24Synaptic vesicle cycle_Homo sapiens_hsa047211.24835050
25Cardiac muscle contraction_Homo sapiens_hsa042601.22918436
26Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.22449830
27Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.21218740
28VEGF signaling pathway_Homo sapiens_hsa043701.20633542
29Insulin resistance_Homo sapiens_hsa049311.18875124
30Oxytocin signaling pathway_Homo sapiens_hsa049211.18642919
31Platelet activation_Homo sapiens_hsa046111.17476978
32Renin secretion_Homo sapiens_hsa049241.14466101
33Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.11790585
34Phenylalanine metabolism_Homo sapiens_hsa003601.11178316
35Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.09737080
36Type II diabetes mellitus_Homo sapiens_hsa049301.09498092
37Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.08380269
38Measles_Homo sapiens_hsa051621.08319720
39Thyroid hormone signaling pathway_Homo sapiens_hsa049191.08110301
40Hematopoietic cell lineage_Homo sapiens_hsa046401.08078060
41Dorso-ventral axis formation_Homo sapiens_hsa043201.03818183
42AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.03314408
43Cocaine addiction_Homo sapiens_hsa050301.02271685
44Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.01933131
45NF-kappa B signaling pathway_Homo sapiens_hsa040641.01872692
46Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.01508169
47Salivary secretion_Homo sapiens_hsa049701.00798147
48Thyroid hormone synthesis_Homo sapiens_hsa049181.00319611
49Histidine metabolism_Homo sapiens_hsa003401.00228435
50Acute myeloid leukemia_Homo sapiens_hsa052211.00010988
51Chemokine signaling pathway_Homo sapiens_hsa040620.98788659
52Toxoplasmosis_Homo sapiens_hsa051450.97427581
53Gap junction_Homo sapiens_hsa045400.96048805
54Adherens junction_Homo sapiens_hsa045200.95834599
55Cholinergic synapse_Homo sapiens_hsa047250.95181756
56Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.95150363
57Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.94363300
58Serotonergic synapse_Homo sapiens_hsa047260.93139793
59Jak-STAT signaling pathway_Homo sapiens_hsa046300.92083235
60Circadian entrainment_Homo sapiens_hsa047130.91365418
61Estrogen signaling pathway_Homo sapiens_hsa049150.89808591
62Arginine biosynthesis_Homo sapiens_hsa002200.89480053
63Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.88778655
64GnRH signaling pathway_Homo sapiens_hsa049120.88664534
65mTOR signaling pathway_Homo sapiens_hsa041500.87157086
66Antigen processing and presentation_Homo sapiens_hsa046120.86873847
67Focal adhesion_Homo sapiens_hsa045100.86865981
68Neurotrophin signaling pathway_Homo sapiens_hsa047220.86121941
69Vascular smooth muscle contraction_Homo sapiens_hsa042700.85516327
70Calcium signaling pathway_Homo sapiens_hsa040200.85475604
71Ovarian steroidogenesis_Homo sapiens_hsa049130.85373830
72Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.84739075
73Chronic myeloid leukemia_Homo sapiens_hsa052200.84725470
74Adipocytokine signaling pathway_Homo sapiens_hsa049200.83600564
752-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.83469260
76Endometrial cancer_Homo sapiens_hsa052130.83343673
77Insulin secretion_Homo sapiens_hsa049110.83300984
78Insulin signaling pathway_Homo sapiens_hsa049100.83080381
79cAMP signaling pathway_Homo sapiens_hsa040240.82655969
80Glucagon signaling pathway_Homo sapiens_hsa049220.82560452
81Tight junction_Homo sapiens_hsa045300.82422278
82Inositol phosphate metabolism_Homo sapiens_hsa005620.82294598
83Taste transduction_Homo sapiens_hsa047420.81605853
84Phospholipase D signaling pathway_Homo sapiens_hsa040720.81252132
85Renal cell carcinoma_Homo sapiens_hsa052110.80262690
86PPAR signaling pathway_Homo sapiens_hsa033200.80036780
87MAPK signaling pathway_Homo sapiens_hsa040100.79822229
88Melanogenesis_Homo sapiens_hsa049160.79242339
89Rap1 signaling pathway_Homo sapiens_hsa040150.78909537
90Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.78774316
91Olfactory transduction_Homo sapiens_hsa047400.78666734
92HIF-1 signaling pathway_Homo sapiens_hsa040660.78219428
93Morphine addiction_Homo sapiens_hsa050320.77347826
94Non-small cell lung cancer_Homo sapiens_hsa052230.77320442
95Colorectal cancer_Homo sapiens_hsa052100.77101645
96Pancreatic cancer_Homo sapiens_hsa052120.76757589
97Glutamatergic synapse_Homo sapiens_hsa047240.76146583
98FoxO signaling pathway_Homo sapiens_hsa040680.75219790
99Choline metabolism in cancer_Homo sapiens_hsa052310.75103780
100Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.73138821
101Pancreatic secretion_Homo sapiens_hsa049720.70855625
102Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.70141333
103Prion diseases_Homo sapiens_hsa050200.69441021
104Glioma_Homo sapiens_hsa052140.68768029
105Dopaminergic synapse_Homo sapiens_hsa047280.68305582
106Longevity regulating pathway - mammal_Homo sapiens_hsa042110.68259905
107Carbohydrate digestion and absorption_Homo sapiens_hsa049730.67551368
108Prolactin signaling pathway_Homo sapiens_hsa049170.67265173
109Lysine degradation_Homo sapiens_hsa003100.66513813
110Proteoglycans in cancer_Homo sapiens_hsa052050.66323533
111ABC transporters_Homo sapiens_hsa020100.65346400
112Long-term depression_Homo sapiens_hsa047300.64871268
113ErbB signaling pathway_Homo sapiens_hsa040120.63258358
114Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.62853578
115Regulation of actin cytoskeleton_Homo sapiens_hsa048100.62148548
116Arginine and proline metabolism_Homo sapiens_hsa003300.61412561
117HTLV-I infection_Homo sapiens_hsa051660.61250007
118Endocytosis_Homo sapiens_hsa041440.59915039
119ECM-receptor interaction_Homo sapiens_hsa045120.59123044
120AMPK signaling pathway_Homo sapiens_hsa041520.59083811
121Amphetamine addiction_Homo sapiens_hsa050310.56924561
122Ras signaling pathway_Homo sapiens_hsa040140.56505802
123Sphingolipid signaling pathway_Homo sapiens_hsa040710.56098014
124Leishmaniasis_Homo sapiens_hsa051400.55668516
125Glycerophospholipid metabolism_Homo sapiens_hsa005640.55490304
126Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.53786628
127Mineral absorption_Homo sapiens_hsa049780.50342272
128Fatty acid degradation_Homo sapiens_hsa000710.50042495
129Amoebiasis_Homo sapiens_hsa051460.48747430
130beta-Alanine metabolism_Homo sapiens_hsa004100.41151923
131Vitamin B6 metabolism_Homo sapiens_hsa007500.39703789
132Fatty acid biosynthesis_Homo sapiens_hsa000610.39184742

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