ABLIM3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the actin-binding LIM (abLIM) family of proteins. These proteins are characterized by an N-terminal LIM domain and a C-terminal dematin-like domain. The encoded protein interacts with actin filaments and may be a component of adherens junctions in several cell types. A variant of this gene may be associated with pain sensitivity in male human patients. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)4.03803239
2response to pheromone (GO:0019236)3.94652686
3fibrinolysis (GO:0042730)3.92758718
4cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.84002148
5negative regulation of fibrinolysis (GO:0051918)3.79749880
6plasma membrane repair (GO:0001778)3.65018823
7cell communication by electrical coupling (GO:0010644)3.63519642
8regulation of synapse structural plasticity (GO:0051823)3.60014768
9cell communication involved in cardiac conduction (GO:0086065)3.58061812
10nucleobase catabolic process (GO:0046113)3.56114269
11regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.55940249
12negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.53796745
13regulation of integrin-mediated signaling pathway (GO:2001044)3.52780442
14regulation of plasminogen activation (GO:0010755)3.50326010
15vocalization behavior (GO:0071625)3.48258235
16blood coagulation, intrinsic pathway (GO:0007597)3.42223537
17positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.41363607
18peptidyl-glutamic acid carboxylation (GO:0017187)3.41149174
19protein carboxylation (GO:0018214)3.41149174
20positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.39323267
21regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.37768428
22platelet degranulation (GO:0002576)3.37579051
23cell-substrate junction assembly (GO:0007044)3.36967228
24regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.33163892
25fatty acid transmembrane transport (GO:1902001)3.33073656
26regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.29085526
27regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.28682006
28negative regulation of potassium ion transmembrane transport (GO:1901380)3.27184628
29synaptic vesicle maturation (GO:0016188)3.26493704
30regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.26408058
31cell adhesion mediated by integrin (GO:0033627)3.26307698
32positive regulation of hemostasis (GO:1900048)3.26037114
33positive regulation of blood coagulation (GO:0030194)3.26037114
34locomotory exploration behavior (GO:0035641)3.25250215
35layer formation in cerebral cortex (GO:0021819)3.24512823
36regulation of fibrinolysis (GO:0051917)3.22803989
37extracellular fibril organization (GO:0043206)3.22585318
38negative regulation of protein localization to cell surface (GO:2000009)3.19441251
39regulation of short-term neuronal synaptic plasticity (GO:0048172)3.17815466
40carnitine shuttle (GO:0006853)3.17181410
41barbed-end actin filament capping (GO:0051016)3.15062785
42negative regulation of hemostasis (GO:1900047)3.14145476
43negative regulation of blood coagulation (GO:0030195)3.14145476
44regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.12193323
45regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.09546656
46activation of protein kinase A activity (GO:0034199)3.05817049
47establishment of nucleus localization (GO:0040023)3.05030106
48cardiac myofibril assembly (GO:0055003)3.04699821
49positive regulation of receptor recycling (GO:0001921)3.04686803
50negative regulation of homotypic cell-cell adhesion (GO:0034111)3.03811079
51triglyceride catabolic process (GO:0019433)3.03100386
52negative regulation of coagulation (GO:0050819)3.01318694
53positive regulation of coagulation (GO:0050820)3.01138798
54stress fiber assembly (GO:0043149)2.97885348
55hemidesmosome assembly (GO:0031581)2.96961893
56protein localization to endosome (GO:0036010)2.95058110
57dendrite morphogenesis (GO:0048813)2.93928935
58gamma-aminobutyric acid transport (GO:0015812)2.93249354
59membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.92830455
60positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.92822779
61regulation of lipoprotein metabolic process (GO:0050746)2.92651249
62L-phenylalanine metabolic process (GO:0006558)2.92546673
63erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.92546673
64sarcomere organization (GO:0045214)2.92261212
65negative regulation of wound healing (GO:0061045)2.91551072
66regulation of glutamate receptor signaling pathway (GO:1900449)2.91505690
67positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.90979893
68ventricular cardiac muscle cell action potential (GO:0086005)2.89569911
69regulation of membrane repolarization (GO:0060306)2.89330338
70glutamate secretion (GO:0014047)2.88453179
71protein heterotrimerization (GO:0070208)2.87223283
72positive regulation of wound healing (GO:0090303)2.86505831
73regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.86240322
74cell migration in hindbrain (GO:0021535)2.85948837
75triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.84813762
76proline transport (GO:0015824)2.84515459
77negative regulation of platelet activation (GO:0010544)2.84111147
78acylglycerol catabolic process (GO:0046464)2.81527122
79neutral lipid catabolic process (GO:0046461)2.81527122
80regulation of cell communication by electrical coupling (GO:0010649)2.80662980
81endodermal cell differentiation (GO:0035987)2.80586876
82positive regulation of potassium ion transmembrane transport (GO:1901381)2.79179246
83synaptic vesicle exocytosis (GO:0016079)2.78597105
84angiogenesis involved in wound healing (GO:0060055)2.76172933
85fibril organization (GO:0097435)2.75567309
86neurotransmitter-gated ion channel clustering (GO:0072578)2.74140968
87sarcoplasmic reticulum calcium ion transport (GO:0070296)2.73995976
88positive regulation of endothelial cell apoptotic process (GO:2000353)2.71289252
89cardiac muscle contraction (GO:0060048)2.68739468
90ionotropic glutamate receptor signaling pathway (GO:0035235)2.68504452
91regulation of protein activation cascade (GO:2000257)2.67791030
92skin morphogenesis (GO:0043589)2.67704809
93focal adhesion assembly (GO:0048041)2.66989947
94cell-substrate adherens junction assembly (GO:0007045)2.66989947
95adherens junction assembly (GO:0034333)2.66874509
96cellular ketone body metabolic process (GO:0046950)2.65830010
97low-density lipoprotein particle clearance (GO:0034383)2.64922303
98cellular potassium ion homeostasis (GO:0030007)2.64542917
99basement membrane organization (GO:0071711)2.63792872
100positive regulation of synapse maturation (GO:0090129)2.63163767
101sodium ion export (GO:0071436)2.63056419
102actin-mediated cell contraction (GO:0070252)2.62252660
103tricarboxylic acid cycle (GO:0006099)2.60650304
104cerebellar granule cell differentiation (GO:0021707)2.60453279
105lysine catabolic process (GO:0006554)2.60337365
106lysine metabolic process (GO:0006553)2.60337365
107neuron recognition (GO:0008038)2.60223634
108regulation of axon extension involved in axon guidance (GO:0048841)2.59563522
109complement activation, alternative pathway (GO:0006957)2.59514563
110regulation of complement activation (GO:0030449)2.59303774
111myofibril assembly (GO:0030239)2.58410428
112platelet aggregation (GO:0070527)2.58397601
113dendritic spine morphogenesis (GO:0060997)2.56930675
114exploration behavior (GO:0035640)2.56267406
115neurotransmitter secretion (GO:0007269)2.56169678
116dicarboxylic acid biosynthetic process (GO:0043650)2.55455383
117positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.54523501
118protein localization to synapse (GO:0035418)2.53841189
119mesodermal cell differentiation (GO:0048333)2.53651565
120alpha-linolenic acid metabolic process (GO:0036109)2.53514779
121regulation of calcium ion transmembrane transporter activity (GO:1901019)2.51356786
122regulation of calcium ion transmembrane transport (GO:1903169)2.51356786
123hypotonic response (GO:0006971)2.50920340
124regulation of axon guidance (GO:1902667)2.50760799
125membrane raft organization (GO:0031579)2.50629764
126axon extension (GO:0048675)2.49949801
1272-oxoglutarate metabolic process (GO:0006103)2.49673700
128regulation of blood coagulation (GO:0030193)2.48956957
129regulation of hemostasis (GO:1900046)2.48956957
130protein targeting to plasma membrane (GO:0072661)2.48614905
131membrane depolarization during action potential (GO:0086010)2.48479972
132neuron cell-cell adhesion (GO:0007158)2.46469339
133negative regulation of smooth muscle cell migration (GO:0014912)2.44623761
134positive regulation of extracellular matrix organization (GO:1903055)2.44230417
135axonal fasciculation (GO:0007413)2.43503840
136substrate-dependent cell migration (GO:0006929)2.42130892
137retina vasculature morphogenesis in camera-type eye (GO:0061299)2.41822165
138regulation of synaptic vesicle exocytosis (GO:2000300)2.41627252
139negative regulation of protein localization to plasma membrane (GO:1903077)2.41540097
140regulation of actin filament-based movement (GO:1903115)2.40651581
141carnitine transmembrane transport (GO:1902603)2.40105046
142cell-matrix adhesion (GO:0007160)2.39769105
143positive regulation of axon extension (GO:0045773)2.39132112
144regulation of coagulation (GO:0050818)2.39012902
145glutamate receptor signaling pathway (GO:0007215)2.38856974
146cellular response to epinephrine stimulus (GO:0071872)2.38531579
147positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.38153229
148regulation of fatty acid oxidation (GO:0046320)2.37944712
149regulation of sequestering of triglyceride (GO:0010889)2.36567058
150cerebellar Purkinje cell differentiation (GO:0021702)2.36496448
151cell migration involved in heart development (GO:0060973)2.36169115
152extracellular matrix assembly (GO:0085029)2.35355426
153synaptic transmission, glutamatergic (GO:0035249)2.35006544
154actin filament depolymerization (GO:0030042)2.33592507
155regulation of early endosome to late endosome transport (GO:2000641)2.33067185
156regulation of the force of heart contraction (GO:0002026)2.31980807
157epithelial cell-cell adhesion (GO:0090136)2.31886399
158regulation of synaptic vesicle transport (GO:1902803)2.31126197
159positive regulation of lipoprotein lipase activity (GO:0051006)2.30688801
160positive regulation of triglyceride lipase activity (GO:0061365)2.30688801
161cardiac conduction (GO:0061337)2.30590164
162regulation of heart rate by cardiac conduction (GO:0086091)2.29032765
163regulation of metalloenzyme activity (GO:0048552)2.28121747
164muscle filament sliding (GO:0030049)2.28004123
165actin-myosin filament sliding (GO:0033275)2.28004123
166regulation of wound healing (GO:0061041)2.26978470
167alanine transport (GO:0032328)2.25942176
168acetyl-CoA metabolic process (GO:0006084)2.25684963
169cytoskeletal anchoring at plasma membrane (GO:0007016)2.25630451
170muscle cell migration (GO:0014812)2.25270526
171ketone body metabolic process (GO:1902224)2.25214203
172potassium ion import (GO:0010107)2.25158959
173L-phenylalanine catabolic process (GO:0006559)2.24499014
174erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.24499014
175synaptic vesicle docking involved in exocytosis (GO:0016081)2.24452024
176cardiac muscle cell action potential involved in contraction (GO:0086002)2.24412053
177positive regulation of Rho protein signal transduction (GO:0035025)2.23434157
178negative regulation of potassium ion transport (GO:0043267)2.23043075
179regulation of relaxation of muscle (GO:1901077)2.22484749
180amino-acid betaine transport (GO:0015838)2.22053126
181negative regulation of adherens junction organization (GO:1903392)2.22001519
182negative regulation of focal adhesion assembly (GO:0051895)2.22001519
183negative regulation of cell junction assembly (GO:1901889)2.22001519
184protein localization to cell surface (GO:0034394)2.21729131
185endocytic recycling (GO:0032456)2.21502546
186desmosome organization (GO:0002934)2.20934681
187negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.18519142
188actin filament-based movement (GO:0030048)2.18512892
189endothelium development (GO:0003158)2.17762972

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.84865781
2RARG_19884340_ChIP-ChIP_MEFs_Mouse3.95560750
3TP63_17297297_ChIP-ChIP_HaCaT_Human3.14391447
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.89678614
5* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.65940741
6PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.57021810
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.46774272
8GATA2_21666600_ChIP-Seq_HMVEC_Human2.43974734
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.38067103
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.38067103
11TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.34678718
12GBX2_23144817_ChIP-Seq_PC3_Human2.31649425
13ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.25845382
14JARID2_20064375_ChIP-Seq_MESCs_Mouse2.25288547
15* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.19310793
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.13321958
17GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.12140064
18SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.11664339
19JARID2_20075857_ChIP-Seq_MESCs_Mouse2.11587368
20SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.11042534
21DROSHA_22980978_ChIP-Seq_HELA_Human2.10746177
22SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.05831600
23EZH2_27294783_Chip-Seq_ESCs_Mouse2.04137948
24EZH2_27304074_Chip-Seq_ESCs_Mouse2.03124914
25NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.99451803
26SUZ12_27294783_Chip-Seq_ESCs_Mouse1.91794490
27RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.91613189
28MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.88114519
29EED_16625203_ChIP-ChIP_MESCs_Mouse1.87783002
30* REST_21632747_ChIP-Seq_MESCs_Mouse1.80749125
31SMAD_19615063_ChIP-ChIP_OVARY_Human1.78567157
32* ELK3_25401928_ChIP-Seq_HUVEC_Human1.77644192
33EP300_21415370_ChIP-Seq_HL-1_Mouse1.69664071
34CJUN_26792858_Chip-Seq_BT549_Human1.69347317
35RNF2_27304074_Chip-Seq_ESCs_Mouse1.68818392
36TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.67186198
37NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.65277912
38* NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.64681669
39CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.62110678
40THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.61799900
41SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.58938973
42PPAR_26484153_Chip-Seq_NCI-H1993_Human1.58717558
43* RXR_22158963_ChIP-Seq_LIVER_Mouse1.58166163
44REST_18959480_ChIP-ChIP_MESCs_Mouse1.57678454
45EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.56916467
46STAT6_21828071_ChIP-Seq_BEAS2B_Human1.56824240
47SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.55914286
48AR_21572438_ChIP-Seq_LNCaP_Human1.55806785
49ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.55792881
50FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.54595001
51RARB_27405468_Chip-Seq_BRAIN_Mouse1.51855275
52ERG_21242973_ChIP-ChIP_JURKAT_Human1.49969775
53SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.46389935
54SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.46389935
55ESR1_21235772_ChIP-Seq_MCF-7_Human1.44521688
56CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.44015440
57* LXR_22158963_ChIP-Seq_LIVER_Mouse1.41015358
58* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.37393971
59* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.36789199
60JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.36490231
61CDX2_19796622_ChIP-Seq_MESCs_Mouse1.33327164
62ESR1_20079471_ChIP-ChIP_T-47D_Human1.32933680
63ZNF274_21170338_ChIP-Seq_K562_Hela1.31801519
64Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.30381266
65KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.29594103
66NR3C1_23031785_ChIP-Seq_PC12_Mouse1.28402213
67KDM2B_26808549_Chip-Seq_K562_Human1.27993310
68HIF1A_21447827_ChIP-Seq_MCF-7_Human1.27818754
69NRF2_20460467_ChIP-Seq_MEFs_Mouse1.25611465
70NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.25611465
71NFIB_24661679_ChIP-Seq_LUNG_Mouse1.25492125
72DNAJC2_21179169_ChIP-ChIP_NT2_Human1.24815280
73P300_27058665_Chip-Seq_ZR-75-30cells_Human1.24255913
74ZNF263_19887448_ChIP-Seq_K562_Human1.24093395
75* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.24023593
76PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.23392644
77ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.19612621
78TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.19590525
79* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.19493703
80RING1B_27294783_Chip-Seq_ESCs_Mouse1.19053194
81UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.16882644
82* SOX2_21211035_ChIP-Seq_LN229_Gbm1.16799427
83ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.16605455
84* BRD4_25478319_ChIP-Seq_HGPS_Human1.16324885
85SMAD4_21799915_ChIP-Seq_A2780_Human1.15672469
86PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.15638173
87* SOX2_20726797_ChIP-Seq_SW620_Human1.15492242
88PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.13780398
89RACK7_27058665_Chip-Seq_MCF-7_Human1.13065780
90PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.12960241
91WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.12601653
92IKZF1_21737484_ChIP-ChIP_HCT116_Human1.12029758
93ESR2_21235772_ChIP-Seq_MCF-7_Human1.11718561
94SMC1_22415368_ChIP-Seq_MEFs_Mouse1.11325612
95ZFP281_18757296_ChIP-ChIP_E14_Mouse1.09445502
96EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.08589996
97TP53_23651856_ChIP-Seq_MEFs_Mouse1.08362980
98WT1_19549856_ChIP-ChIP_CCG9911_Human1.08342292
99KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.08327258
100P63_26484246_Chip-Seq_KERATINOCYTES_Human1.08153974
101CTBP2_25329375_ChIP-Seq_LNCAP_Human1.07498534
102* AHR_22903824_ChIP-Seq_MCF-7_Human1.06800202
103TAF15_26573619_Chip-Seq_HEK293_Human1.06316257
104SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.05843819
105SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.05834310
106CTCF_27219007_Chip-Seq_Bcells_Human1.05342431
107* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.05122760
108SMAD4_21741376_ChIP-Seq_HESCs_Human1.04668609
109* AR_19668381_ChIP-Seq_PC3_Human1.03818539
110TP53_18474530_ChIP-ChIP_U2OS_Human1.03009716
111SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.02850124
112BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.02179522
113MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.01892533
114GATA1_19941827_ChIP-Seq_MEL_Mouse1.01365250
115CTNNB1_20460455_ChIP-Seq_HCT116_Human0.99957580
116SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.99652213
117KDM2B_26808549_Chip-Seq_SUP-B15_Human0.98883681
118TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.98611576
119* ARNT_22903824_ChIP-Seq_MCF-7_Human0.98140724
120RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.98072478
121ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.97293128
122TBX20_22080862_ChIP-Seq_HEART_Mouse0.97133314
123TBX20_22328084_ChIP-Seq_HEART_Mouse0.97133314
124EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.96530301
125GATA1_19941826_ChIP-Seq_K562_Human0.95694688
126AR_25329375_ChIP-Seq_VCAP_Human0.95117974
127BCAT_22108803_ChIP-Seq_LS180_Human0.94595918
128UBF1/2_26484160_Chip-Seq_HMECs_Human0.94519958
129CTBP1_25329375_ChIP-Seq_LNCAP_Human0.94315385
130SALL4_18804426_ChIP-ChIP_XEN_Mouse0.94124143
131TRIM28_21343339_ChIP-Seq_HEK293_Human0.93764209
132CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.93147810
133CLOCK_20551151_ChIP-Seq_293T_Human0.92938830
134FOXO3_23340844_ChIP-Seq_DLD1_Human0.92497141
135TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92125821
136RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.92065829
137RING1B_27294783_Chip-Seq_NPCs_Mouse0.91255590
138TP53_16413492_ChIP-PET_HCT116_Human0.90755508
139RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.90334829
140CBX2_27304074_Chip-Seq_ESCs_Mouse0.90306430
141LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.89255381
142TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.88505734
143PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.87571550
144LXR_22292898_ChIP-Seq_THP-1_Human0.86943808
145SMAD3_21741376_ChIP-Seq_HESCs_Human0.86919201
146* SMC3_22415368_ChIP-Seq_MEFs_Mouse0.86810254
147PIAS1_25552417_ChIP-Seq_VCAP_Human0.86631583
148* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.86510169
149FOXA2_19822575_ChIP-Seq_HepG2_Human0.86404164
150TP53_20018659_ChIP-ChIP_R1E_Mouse0.86212369
151SMAD3_21741376_ChIP-Seq_EPCs_Human0.85911422
152STAT3_23295773_ChIP-Seq_U87_Human0.85539088
153GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85230669
154ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.84950492
155MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.82185057
156TOP2B_26459242_ChIP-Seq_MCF-7_Human0.82031658
157TET1_21490601_ChIP-Seq_MESCs_Mouse0.80348782
158* NR3C1_21868756_ChIP-Seq_MCF10A_Human0.79871393

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.34799727
2MP0002837_dystrophic_cardiac_calcinosis3.99513913
3MP0004859_abnormal_synaptic_plasticity3.87759104
4MP0003705_abnormal_hypodermis_morpholog3.55162187
5MP0000751_myopathy3.43713204
6MP0003566_abnormal_cell_adhesion3.20515239
7MP0004084_abnormal_cardiac_muscle2.83916524
8MP0004215_abnormal_myocardial_fiber2.75022705
9MP0003950_abnormal_plasma_membrane2.74719078
10MP0003646_muscle_fatigue2.67778954
11MP0003635_abnormal_synaptic_transmissio2.53812065
12MP0004130_abnormal_muscle_cell2.52430745
13MP0004270_analgesia2.50893722
14MP0003279_aneurysm2.33050699
15MP0004036_abnormal_muscle_relaxation2.32815522
16MP0005275_abnormal_skin_tensile2.32801211
17MP0005464_abnormal_platelet_physiology2.18335236
18MP0003191_abnormal_cellular_cholesterol2.17458615
19MP0001958_emphysema2.12505013
20MP0005360_urolithiasis2.08502575
21MP0003880_abnormal_central_pattern2.01300830
22MP0002063_abnormal_learning/memory/cond1.95012810
23MP0005023_abnormal_wound_healing1.91397309
24MP0003137_abnormal_impulse_conducting1.91378066
25MP0002139_abnormal_hepatobiliary_system1.88904230
26MP0004145_abnormal_muscle_electrophysio1.82517427
27MP0005330_cardiomyopathy1.79551175
28MP0003828_pulmonary_edema1.79531409
29MP0001968_abnormal_touch/_nociception1.78877134
30MP0003091_abnormal_cell_migration1.77939182
31MP0000749_muscle_degeneration1.77923293
32MP0009745_abnormal_behavioral_response1.73941316
33MP0004087_abnormal_muscle_fiber1.73795134
34MP0005365_abnormal_bile_salt1.72992246
35MP0009046_muscle_twitch1.72524881
36MP0002735_abnormal_chemical_nociception1.72069645
37MP0010368_abnormal_lymphatic_system1.71824786
38MP0005085_abnormal_gallbladder_physiolo1.71070537
39MP0002734_abnormal_mechanical_nocicepti1.70993792
40MP0005423_abnormal_somatic_nervous1.70535604
41MP0003329_amyloid_beta_deposits1.68899891
42MP0006276_abnormal_autonomic_nervous1.68707571
43MP0005620_abnormal_muscle_contractility1.66492563
44MP0004085_abnormal_heartbeat1.66185887
45MP0002972_abnormal_cardiac_muscle1.64945474
46MP0009780_abnormal_chondrocyte_physiolo1.62065665
47MP0001440_abnormal_grooming_behavior1.60657889
48MP0005375_adipose_tissue_phenotype1.60218294
49MP0002064_seizures1.57617048
50MP0002909_abnormal_adrenal_gland1.56110206
51MP0006138_congestive_heart_failure1.53704876
52MP0005670_abnormal_white_adipose1.53105081
53MP0005503_abnormal_tendon_morphology1.52536875
54MP0002572_abnormal_emotion/affect_behav1.51079956
55MP0000003_abnormal_adipose_tissue1.46364133
56MP0004484_altered_response_of1.45529242
57MP0002184_abnormal_innervation1.45449333
58MP0008775_abnormal_heart_ventricle1.44921749
59MP0002733_abnormal_thermal_nociception1.44168876
60MP0000343_altered_response_to1.43478622
61MP0004858_abnormal_nervous_system1.42867559
62MP0005165_increased_susceptibility_to1.40860444
63MP0002272_abnormal_nervous_system1.40581173
64MP0000747_muscle_weakness1.39640979
65MP0000767_abnormal_smooth_muscle1.38495766
66MP0002877_abnormal_melanocyte_morpholog1.37872282
67MP0001542_abnormal_bone_strength1.37716058
68MP0010329_abnormal_lipoprotein_level1.37353276
69MP0009840_abnormal_foam_cell1.36643002
70MP0002295_abnormal_pulmonary_circulatio1.36464417
71MP0008004_abnormal_stomach_pH1.35844655
72MP0005385_cardiovascular_system_phenoty1.35192974
73MP0001544_abnormal_cardiovascular_syste1.35192974
74MP0002106_abnormal_muscle_physiology1.35079653
75MP0008961_abnormal_basal_metabolism1.31868751
76MP0001501_abnormal_sleep_pattern1.31336918
77MP0005595_abnormal_vascular_smooth1.30557992
78MP0002067_abnormal_sensory_capabilities1.29820586
79MP0002269_muscular_atrophy1.28993798
80MP0000759_abnormal_skeletal_muscle1.26252499
81MP0000750_abnormal_muscle_regeneration1.25436317
82MP0000778_abnormal_nervous_system1.24995960
83MP0008569_lethality_at_weaning1.22494906
84MP0005386_behavior/neurological_phenoty1.21684426
85MP0004924_abnormal_behavior1.21684426
86MP0005257_abnormal_intraocular_pressure1.20008355
87MP0003868_abnormal_feces_composition1.19414416
88MP0008875_abnormal_xenobiotic_pharmacok1.19371047
89MP0001486_abnormal_startle_reflex1.18562142
90MP0001970_abnormal_pain_threshold1.17941145
91MP0002736_abnormal_nociception_after1.16866912
92MP0002332_abnormal_exercise_endurance1.15587385
93MP0005409_darkened_coat_color1.15287646
94MP0005083_abnormal_biliary_tract1.13183632
95MP0003122_maternal_imprinting1.11760949
96MP0005666_abnormal_adipose_tissue1.10660237
97MP0004233_abnormal_muscle_weight1.10528101
98MP0005164_abnormal_response_to1.10495085
99MP0005645_abnormal_hypothalamus_physiol1.09655153
100MP0005369_muscle_phenotype1.08142596
101MP0005535_abnormal_body_temperature1.07679398
102MP0000733_abnormal_muscle_development1.06390860
103MP0005167_abnormal_blood-brain_barrier1.05648703
104MP0010630_abnormal_cardiac_muscle1.04979749
105MP0002108_abnormal_muscle_morphology1.03336730
106MP0000249_abnormal_blood_vessel1.02903385
107MP0002060_abnormal_skin_morphology1.02592108
108MP0001502_abnormal_circadian_rhythm1.01508550
109MP0004811_abnormal_neuron_physiology0.98304545
110MP0002557_abnormal_social/conspecific_i0.98127645
111MP0002118_abnormal_lipid_homeostasis0.98016929
112MP0002896_abnormal_bone_mineralization0.96711502
113MP0000013_abnormal_adipose_tissue0.95874149
114MP0003252_abnormal_bile_duct0.95680579
115MP0000955_abnormal_spinal_cord0.95538970
116MP0002128_abnormal_blood_circulation0.95527598
117MP0002066_abnormal_motor_capabilities/c0.94760926
118MP0004510_myositis0.93062874
119MP0005058_abnormal_lysosome_morphology0.91342242
120MP0005187_abnormal_penis_morphology0.91242462
121MP0001661_extended_life_span0.90843466
122MP0001984_abnormal_olfaction0.90765218
123MP0000230_abnormal_systemic_arterial0.89650026
124MP0000858_altered_metastatic_potential0.89364858
125MP0002822_catalepsy0.88702795
126MP0002971_abnormal_brown_adipose0.88613828
127MP0005623_abnormal_meninges_morphology0.87045826
128MP0001879_abnormal_lymphatic_vessel0.84550029
129MP0004272_abnormal_basement_membrane0.83939035
130MP0005451_abnormal_body_composition0.83694980
131MP0003633_abnormal_nervous_system0.83424856
132MP0009053_abnormal_anal_canal0.82468039
133MP0003075_altered_response_to0.81838905
134MP0003879_abnormal_hair_cell0.81630933
135MP0005332_abnormal_amino_acid0.81137296
136MP0000604_amyloidosis0.80540345
137MP0002882_abnormal_neuron_morphology0.78867347
138MP0008874_decreased_physiological_sensi0.78793952
139MP0001849_ear_inflammation0.78769840
140MP0001915_intracranial_hemorrhage0.78495489
141MP0003690_abnormal_glial_cell0.78473906
142MP0004147_increased_porphyrin_level0.77870767
143MP0009384_cardiac_valve_regurgitation0.75005108
144MP0000762_abnormal_tongue_morphology0.73721521
145MP0003453_abnormal_keratinocyte_physiol0.73347546
146MP0004185_abnormal_adipocyte_glucose0.71775351
147MP0001299_abnormal_eye_distance/0.68872850
148MP0000467_abnormal_esophagus_morphology0.67970815
149MP0001614_abnormal_blood_vessel0.67677915
150MP0004883_abnormal_blood_vessel0.67271617
151MP0003941_abnormal_skin_development0.66681339
152MP0006054_spinal_hemorrhage0.65599212

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)4.77104779
2Protrusio acetabuli (HP:0003179)4.69584523
3Menorrhagia (HP:0000132)4.27610911
4Premature rupture of membranes (HP:0001788)4.19554788
5Exercise-induced myalgia (HP:0003738)4.12290167
6Increased mean platelet volume (HP:0011877)4.08393614
7Myokymia (HP:0002411)3.94597014
8Abnormal platelet volume (HP:0011876)3.65982756
9Difficulty running (HP:0009046)3.56241882
10Aortic aneurysm (HP:0004942)3.55843540
11Hyporeflexia of lower limbs (HP:0002600)3.48684612
12Distal lower limb muscle weakness (HP:0009053)3.46172997
13Calf muscle hypertrophy (HP:0008981)3.45047847
14Spinal rigidity (HP:0003306)3.41713580
15Myotonia (HP:0002486)3.38121282
16Focal motor seizures (HP:0011153)3.30104953
17Atrial fibrillation (HP:0005110)3.28045762
18Muscle fiber splitting (HP:0003555)3.24854433
19Distal lower limb amyotrophy (HP:0008944)3.23204353
20Vascular tortuosity (HP:0004948)3.21965215
21Primary atrial arrhythmia (HP:0001692)3.20008330
22Muscle hypertrophy of the lower extremities (HP:0008968)3.18376619
23Ventricular fibrillation (HP:0001663)3.14902823
24Ventricular tachycardia (HP:0004756)3.10476417
25Action tremor (HP:0002345)3.10065090
26Visual hallucinations (HP:0002367)3.09658141
27Bundle branch block (HP:0011710)3.09213070
28Prolonged QT interval (HP:0001657)3.07646090
29Syncope (HP:0001279)3.05250791
30Mildly elevated creatine phosphokinase (HP:0008180)3.03651648
31Aortic dissection (HP:0002647)3.02250765
32Supraventricular tachycardia (HP:0004755)3.00651322
33Supraventricular arrhythmia (HP:0005115)2.99620731
34Nemaline bodies (HP:0003798)2.98538982
35Abnormality of the lower motor neuron (HP:0002366)2.98534664
36Arterial tortuosity (HP:0005116)2.95981253
37Abnormality of the calf musculature (HP:0001430)2.95565566
38Focal seizures (HP:0007359)2.91760948
39Deep venous thrombosis (HP:0002625)2.85783778
40Joint hemorrhage (HP:0005261)2.85307977
41Prolonged bleeding time (HP:0003010)2.85128212
42Purpura (HP:0000979)2.84908766
43Right ventricular cardiomyopathy (HP:0011663)2.82137713
44Ankle contracture (HP:0006466)2.81069232
45Myoglobinuria (HP:0002913)2.80417845
46Progressive cerebellar ataxia (HP:0002073)2.78476604
47Exercise-induced muscle cramps (HP:0003710)2.76598835
48Abnormality of complement system (HP:0005339)2.74020050
49Atrophic scars (HP:0001075)2.72207590
50Lower limb amyotrophy (HP:0007210)2.70583302
51Round ear (HP:0100830)2.67845762
52Mitral stenosis (HP:0001718)2.66793144
53Abnormality of monocarboxylic acid metabolism (HP:0010996)2.64868149
54EMG: myopathic abnormalities (HP:0003458)2.62618693
55Ventricular arrhythmia (HP:0004308)2.57411609
56Abnormality of the Achilles tendon (HP:0005109)2.55142183
57Increased variability in muscle fiber diameter (HP:0003557)2.54727389
58Atrioventricular block (HP:0001678)2.53839264
59Increased connective tissue (HP:0009025)2.51447949
60Heart block (HP:0012722)2.50331669
61Abnormal EKG (HP:0003115)2.49432990
62Abnormality of the common coagulation pathway (HP:0010990)2.48477347
63Polyphagia (HP:0002591)2.48264836
64Poor eye contact (HP:0000817)2.45500658
65Dysmetric saccades (HP:0000641)2.45448686
66Wormian bones (HP:0002645)2.45211237
67Abnormal social behavior (HP:0012433)2.45107859
68Impaired social interactions (HP:0000735)2.45107859
69Slender build (HP:0001533)2.43950875
70Ketoacidosis (HP:0001993)2.43694668
71Vertebral compression fractures (HP:0002953)2.43293111
72Fragile skin (HP:0001030)2.38540384
73Cardiovascular calcification (HP:0011915)2.36919308
74Difficulty climbing stairs (HP:0003551)2.36791406
75Pheochromocytoma (HP:0002666)2.34837100
76Neck muscle weakness (HP:0000467)2.33718590
77Follicular hyperkeratosis (HP:0007502)2.33414507
78Abnormal atrioventricular conduction (HP:0005150)2.31722830
79Ketosis (HP:0001946)2.31688210
80Gingival bleeding (HP:0000225)2.31472461
81Cerebral aneurysm (HP:0004944)2.31284863
82Lipoatrophy (HP:0100578)2.28544633
83Failure to thrive in infancy (HP:0001531)2.28457760
84Epistaxis (HP:0000421)2.28359103
85Rapidly progressive (HP:0003678)2.27004499
86Reduced subcutaneous adipose tissue (HP:0003758)2.26510904
87Supranuclear gaze palsy (HP:0000605)2.23986353
88Palpitations (HP:0001962)2.22708275
89Abnormal eating behavior (HP:0100738)2.22242849
90Achilles tendon contracture (HP:0001771)2.22200610
91Abnormality of skeletal muscle fiber size (HP:0012084)2.21932318
92Abnormal platelet function (HP:0011869)2.21080155
93Impaired platelet aggregation (HP:0003540)2.21080155
94Fetal akinesia sequence (HP:0001989)2.19794969
95Back pain (HP:0003418)2.15707223
96Lymphangioma (HP:0100764)2.13656472
97Generalized tonic-clonic seizures (HP:0002069)2.13620885
98Type 1 muscle fiber predominance (HP:0003803)2.12194957
99Osteolytic defects of the hand bones (HP:0009699)2.11343757
100Osteolytic defects of the phalanges of the hand (HP:0009771)2.11343757
101Generalized amyotrophy (HP:0003700)2.11167042
102Subaortic stenosis (HP:0001682)2.11096055
103Abnormality of the left ventricular outflow tract (HP:0011103)2.11096055
104Shallow orbits (HP:0000586)2.10737613
105Asymmetric septal hypertrophy (HP:0001670)2.09946952
106Hyperventilation (HP:0002883)2.09543057
107Mutism (HP:0002300)2.08747278
108Broad-based gait (HP:0002136)2.08454649
109Abnormality of aromatic amino acid family metabolism (HP:0004338)2.06999796
110Aneurysm (HP:0002617)2.06321763
111Scapular winging (HP:0003691)2.06148911
112Depression (HP:0000716)2.05424274
113Cervical subluxation (HP:0003308)2.04399512
114Vascular calcification (HP:0004934)2.04226417
115Upper limb amyotrophy (HP:0009129)2.02774986
116Distal upper limb amyotrophy (HP:0007149)2.02774986
117Hyperlipoproteinemia (HP:0010980)2.02070020
118Gowers sign (HP:0003391)2.02027441
119Myocardial infarction (HP:0001658)2.01406321
120Torticollis (HP:0000473)2.01385352
121Distal arthrogryposis (HP:0005684)2.01091793
122Dysdiadochokinesis (HP:0002075)2.01070214
123Complement deficiency (HP:0004431)2.00828683
124Genetic anticipation (HP:0003743)2.00403816
125Polycythemia (HP:0001901)2.00392917
126Hemiplegia (HP:0002301)1.99954254
127Dilatation of the ascending aorta (HP:0005111)1.99526636
128Centrally nucleated skeletal muscle fibers (HP:0003687)1.98739886
129Oligomenorrhea (HP:0000876)1.98733008
130Absence seizures (HP:0002121)1.98257352
131Xanthomatosis (HP:0000991)1.95643809
132Anxiety (HP:0000739)1.94928585
133Abnormal delivery (HP:0001787)1.94611455
134Drooling (HP:0002307)1.94443532
135Excessive salivation (HP:0003781)1.94443532
136Acanthosis nigricans (HP:0000956)1.93221119
137Epidermoid cyst (HP:0200040)1.93020544
138Muscle stiffness (HP:0003552)1.92587839
139Ulnar deviation of the wrist (HP:0003049)1.92109736
140Scanning speech (HP:0002168)1.91815456
141Hyperammonemia (HP:0001987)1.91081736
142Bladder diverticulum (HP:0000015)1.90695742
143Ankle clonus (HP:0011448)1.90639426
144EMG: neuropathic changes (HP:0003445)1.90542653
145Blue sclerae (HP:0000592)1.89611461
146Neuroendocrine neoplasm (HP:0100634)1.87806607
147Broad metatarsal (HP:0001783)1.87452442
148Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.85425782
149Hemorrhage of the eye (HP:0011885)1.85113763
150Popliteal pterygium (HP:0009756)1.81983863
151Cerebral hemorrhage (HP:0001342)1.80655454
152Dilated cardiomyopathy (HP:0001644)1.80557410
153Conjugated hyperbilirubinemia (HP:0002908)1.80499658
154Muscle fiber inclusion bodies (HP:0100299)1.80366690
155Hypertriglyceridemia (HP:0002155)1.80212366
156Abnormality of the intrinsic pathway (HP:0010989)1.79861800
157Soft skin (HP:0000977)1.79164081
158Postural instability (HP:0002172)1.78908949
159Mitral valve prolapse (HP:0001634)1.78649864
160Hypoalphalipoproteinemia (HP:0003233)1.78357660
161Axonal loss (HP:0003447)1.77751015
162Obstructive sleep apnea (HP:0002870)1.77270136
163Dysmetria (HP:0001310)1.76973944
164Epileptic encephalopathy (HP:0200134)1.76287728
165Neonatal onset (HP:0003623)1.76097621
166Skin nodule (HP:0200036)1.76053767
167Urinary urgency (HP:0000012)1.75839657
168Atonic seizures (HP:0010819)1.75831152
169Abnormality of the corticospinal tract (HP:0002492)1.74574117
170Hyperglycinuria (HP:0003108)1.73377974
171Focal dystonia (HP:0004373)1.71104867
172Cerebral inclusion bodies (HP:0100314)1.70355469

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK13.99351234
2PHKG13.11569443
3PHKG23.11569443
4NTRK32.88443901
5TIE12.33363357
6MAP2K42.31867336
7TESK12.27066712
8MAP3K92.26175938
9MAP3K42.25893858
10TGFBR22.18327945
11PTK22.10748392
12LMTK22.07320106
13MINK12.04155371
14LIMK12.03376400
15RIPK11.89653692
16DDR21.84668355
17DAPK21.84120540
18MET1.82877801
19NTRK21.81161849
20MOS1.78258922
21TRIB31.75736535
22PIK3CG1.72605133
23TTN1.69029906
24ARAF1.67199732
25PAK61.66067099
26MST1R1.65444087
27LATS21.62624895
28EPHA41.57643141
29EPHB11.52625307
30MAP2K71.50030994
31MAPKAPK31.48026598
32ERN11.45674831
33EPHA21.44174366
34PDK31.43378035
35PDK41.43378035
36BMX1.43285114
37MARK21.38139435
38MAP3K61.35135269
39PAK41.34748999
40KSR21.29503703
41IRAK31.28633068
42PAK31.28204576
43GRK51.27612177
44MAPK121.26813850
45MYLK1.22716159
46EPHB21.21692111
47OBSCN1.21614377
48NEK91.21284981
49STK381.20427123
50PINK11.18726150
51PRPF4B1.16863692
52TRPM71.15800168
53PAK21.15374092
54KSR11.13556706
55BCKDK1.11267606
56MAPK131.11212512
57CAMKK11.08333120
58FER1.07967053
59CAMK1G1.07190197
60PDGFRB1.04683665
61CDK51.03702275
62ILK1.02412967
63ABL21.01536737
64MAP3K31.00158714
65NTRK10.99613570
66RET0.99281207
67DMPK0.98952658
68SIK20.94408621
69MAP3K70.93917794
70PKN20.93446275
71MAP3K120.90581628
72PRKD20.90552645
73PIM20.88351755
74CAMK2A0.86480328
75DAPK30.85951846
76ERBB40.85650466
77ROCK20.85130028
78CAMK10.84527654
79PRKD30.84331065
80SIK10.83618626
81ZAP700.83394159
82LATS10.80566304
83PRKCH0.79512130
84PDK20.79099672
85PRKAA10.78017157
86NEK10.77789639
87CAMK40.76649549
88SGK30.75881228
89TAOK20.75358960
90MAP2K30.74280629
91CAMKK20.73989828
92SGK4940.73087775
93SGK2230.73087775
94PTK2B0.72961143
95FLT30.71792565
96MAP3K130.71388631
97TYRO30.70930832
98PRKCG0.70223070
99SGK20.70016517
100CAMK1D0.69908397
101TAOK10.68279344
102SIK30.66168963
103PKN10.65557692
104PRKD10.65426221
105STK110.64953488
106ADRBK10.63938621
107PDGFRA0.63528411
108ERBB30.63428394
109INSRR0.62226511
110MUSK0.61919153
111PRKG20.61396940
112MAP2K10.60659498
113CAMK2D0.60506353
114PDPK10.60354838
115ROCK10.58285351
116MAP3K10.57416583
117FGFR40.57182796
118CAMK2G0.57150768
119PRKCZ0.56775360
120ICK0.55613163
121PRKACG0.55397139
122PAK10.55291553
123RPS6KA20.55205682
124CDC42BPA0.55025444
125MAP3K20.54777137
126CAMK2B0.53994992
127DYRK20.53859205
128FES0.53849906
129GRK70.53771339
130BCR0.53725818
131TNIK0.53483414
132FGFR20.51787236
133PIK3CA0.51142047
134CDK180.51118390
135CDK140.50800238
136CSNK1G20.50594990
137UHMK10.50451006
138WNK10.50326275
139PRKAA20.49532904
140PRKCE0.48912728
141MAP2K60.48212063
142MAPK40.45732096
143MAP3K50.44978060
144PDK10.43849071
145GSK3A0.41995783
146MTOR0.41059360
147MAPK70.40532578
148SRC0.37506958
149PRKG10.33574461

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045122.80303930
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.58690978
3Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.25309757
4Nicotine addiction_Homo sapiens_hsa050332.06407873
52-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.04337542
6Focal adhesion_Homo sapiens_hsa045102.03051360
7Nitrogen metabolism_Homo sapiens_hsa009101.95688697
8Fatty acid degradation_Homo sapiens_hsa000711.83723986
9Arginine biosynthesis_Homo sapiens_hsa002201.82928799
10Primary bile acid biosynthesis_Homo sapiens_hsa001201.79403811
11Propanoate metabolism_Homo sapiens_hsa006401.76379709
12Cardiac muscle contraction_Homo sapiens_hsa042601.74962268
13Dilated cardiomyopathy_Homo sapiens_hsa054141.70834346
14Butanoate metabolism_Homo sapiens_hsa006501.68349080
15Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.63223793
16Circadian entrainment_Homo sapiens_hsa047131.60856380
17Fatty acid metabolism_Homo sapiens_hsa012121.60321543
18Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.57665823
19Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.55686820
20Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.54274219
21GABAergic synapse_Homo sapiens_hsa047271.53321013
22PPAR signaling pathway_Homo sapiens_hsa033201.52741406
23Synaptic vesicle cycle_Homo sapiens_hsa047211.51141620
24Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.50042951
25Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.47758362
26Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.45373656
27Glutamatergic synapse_Homo sapiens_hsa047241.43217867
28Platelet activation_Homo sapiens_hsa046111.41087409
29Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.39777917
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.33513240
31Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.32450845
32Long-term potentiation_Homo sapiens_hsa047201.31579538
33Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.31197871
34Bile secretion_Homo sapiens_hsa049761.30503563
35Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.26308911
36Tryptophan metabolism_Homo sapiens_hsa003801.25686863
37Aldosterone synthesis and secretion_Homo sapiens_hsa049251.23726656
38Renin secretion_Homo sapiens_hsa049241.22938348
39Amoebiasis_Homo sapiens_hsa051461.22204688
40Salivary secretion_Homo sapiens_hsa049701.20322134
41Morphine addiction_Homo sapiens_hsa050321.20187747
42Insulin secretion_Homo sapiens_hsa049111.17268022
43Retinol metabolism_Homo sapiens_hsa008301.16933119
44Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.16562185
45Regulation of actin cytoskeleton_Homo sapiens_hsa048101.14415206
46Olfactory transduction_Homo sapiens_hsa047401.12926357
47Oxytocin signaling pathway_Homo sapiens_hsa049211.12003743
48Taste transduction_Homo sapiens_hsa047421.11242726
49Dopaminergic synapse_Homo sapiens_hsa047281.08381967
50Gastric acid secretion_Homo sapiens_hsa049711.07810831
51Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.07114064
52Chemical carcinogenesis_Homo sapiens_hsa052041.06688465
53Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.06444362
54Glycosaminoglycan degradation_Homo sapiens_hsa005311.05937478
55Amphetamine addiction_Homo sapiens_hsa050311.05068606
56Proteoglycans in cancer_Homo sapiens_hsa052051.04755072
57Type II diabetes mellitus_Homo sapiens_hsa049301.04655704
58Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.04009895
59Cholinergic synapse_Homo sapiens_hsa047251.03113282
60Pyruvate metabolism_Homo sapiens_hsa006201.02144333
61Calcium signaling pathway_Homo sapiens_hsa040201.00825567
62Adherens junction_Homo sapiens_hsa045200.95272477
63Pentose and glucuronate interconversions_Homo sapiens_hsa000400.94885609
64Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.94747552
65Fatty acid biosynthesis_Homo sapiens_hsa000610.94092104
66Carbon metabolism_Homo sapiens_hsa012000.93303915
67* Axon guidance_Homo sapiens_hsa043600.92948443
68Steroid hormone biosynthesis_Homo sapiens_hsa001400.91950462
69Gap junction_Homo sapiens_hsa045400.89681247
70Long-term depression_Homo sapiens_hsa047300.89381528
71Histidine metabolism_Homo sapiens_hsa003400.89359539
72Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.88790565
73cAMP signaling pathway_Homo sapiens_hsa040240.86391755
74GnRH signaling pathway_Homo sapiens_hsa049120.85362931
75Glucagon signaling pathway_Homo sapiens_hsa049220.84816992
76cGMP-PKG signaling pathway_Homo sapiens_hsa040220.84566437
77Drug metabolism - other enzymes_Homo sapiens_hsa009830.84019486
78Complement and coagulation cascades_Homo sapiens_hsa046100.82769763
79AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.81825401
80Arginine and proline metabolism_Homo sapiens_hsa003300.79464572
81Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.77191680
82Adipocytokine signaling pathway_Homo sapiens_hsa049200.76991737
83Insulin signaling pathway_Homo sapiens_hsa049100.76826589
84Endocytosis_Homo sapiens_hsa041440.74951423
85beta-Alanine metabolism_Homo sapiens_hsa004100.74481901
86Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.72651386
87Estrogen signaling pathway_Homo sapiens_hsa049150.72074073
88Cocaine addiction_Homo sapiens_hsa050300.70541309
89Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.69521250
90AMPK signaling pathway_Homo sapiens_hsa041520.69403604
91Vascular smooth muscle contraction_Homo sapiens_hsa042700.69309857
92Dorso-ventral axis formation_Homo sapiens_hsa043200.68649853
93Insulin resistance_Homo sapiens_hsa049310.68232102
94Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.68127444
95Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.66718456
96Peroxisome_Homo sapiens_hsa041460.66264550
97Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.65570866
98Leukocyte transendothelial migration_Homo sapiens_hsa046700.64860404
99Glycerolipid metabolism_Homo sapiens_hsa005610.64252002
100Serotonergic synapse_Homo sapiens_hsa047260.61880913
101Small cell lung cancer_Homo sapiens_hsa052220.61789962
102Phenylalanine metabolism_Homo sapiens_hsa003600.59116536
103Renal cell carcinoma_Homo sapiens_hsa052110.58974460
104PI3K-Akt signaling pathway_Homo sapiens_hsa041510.58957198
105Arachidonic acid metabolism_Homo sapiens_hsa005900.58552097
106Tight junction_Homo sapiens_hsa045300.57813447
107Prion diseases_Homo sapiens_hsa050200.57023000
108Rap1 signaling pathway_Homo sapiens_hsa040150.56049465
109Pentose phosphate pathway_Homo sapiens_hsa000300.55545614
110Starch and sucrose metabolism_Homo sapiens_hsa005000.55200196
111Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.54942739
112Alzheimers disease_Homo sapiens_hsa050100.54790894
113Longevity regulating pathway - mammal_Homo sapiens_hsa042110.50222058
114Fatty acid elongation_Homo sapiens_hsa000620.49872517
115Lysine degradation_Homo sapiens_hsa003100.48940555
116Fat digestion and absorption_Homo sapiens_hsa049750.48262870
117Galactose metabolism_Homo sapiens_hsa000520.47373202
118Melanogenesis_Homo sapiens_hsa049160.46355467
119Phospholipase D signaling pathway_Homo sapiens_hsa040720.45668619
120Shigellosis_Homo sapiens_hsa051310.45630757
121Thyroid hormone signaling pathway_Homo sapiens_hsa049190.45079364
122VEGF signaling pathway_Homo sapiens_hsa043700.44814602
123Protein digestion and absorption_Homo sapiens_hsa049740.43641463
124Vitamin B6 metabolism_Homo sapiens_hsa007500.43011404
125Malaria_Homo sapiens_hsa051440.42214281
126Glioma_Homo sapiens_hsa052140.42141099
127Sulfur metabolism_Homo sapiens_hsa009200.42059870
128Central carbon metabolism in cancer_Homo sapiens_hsa052300.42030390
129Circadian rhythm_Homo sapiens_hsa047100.41886202
130Phosphatidylinositol signaling system_Homo sapiens_hsa040700.41856600
131Bladder cancer_Homo sapiens_hsa052190.41794206
132Pertussis_Homo sapiens_hsa051330.41767628
133Vibrio cholerae infection_Homo sapiens_hsa051100.41513226
134Parkinsons disease_Homo sapiens_hsa050120.41232365
135Tyrosine metabolism_Homo sapiens_hsa003500.41225929
136Chronic myeloid leukemia_Homo sapiens_hsa052200.40990362
137Thyroid hormone synthesis_Homo sapiens_hsa049180.39007289
138ErbB signaling pathway_Homo sapiens_hsa040120.38707046
139Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.38346421
140Ovarian steroidogenesis_Homo sapiens_hsa049130.37915556
141Biosynthesis of amino acids_Homo sapiens_hsa012300.37682983
142Pancreatic secretion_Homo sapiens_hsa049720.37170511
143Caffeine metabolism_Homo sapiens_hsa002320.36769730

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