ABR

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that is similar to the protein encoded by the breakpoint cluster region gene located on chromosome 22. The protein encoded by this gene contains a GTPase-activating protein domain, a domain found in members of the Rho family of GTP-binding proteins. Functional studies in mice determined that this protein plays a role in vestibular morphogenesis. Alternatively spliced transcript variants have been reported for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.02576294
2synaptic vesicle maturation (GO:0016188)5.93200539
3locomotory exploration behavior (GO:0035641)5.69395813
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.31295639
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.16929882
6synaptic vesicle exocytosis (GO:0016079)5.15232501
7vocalization behavior (GO:0071625)5.04793397
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.94458771
9glutamate secretion (GO:0014047)4.94044615
10regulation of glutamate receptor signaling pathway (GO:1900449)4.76687788
11regulation of synaptic vesicle exocytosis (GO:2000300)4.67531455
12ionotropic glutamate receptor signaling pathway (GO:0035235)4.66957600
13synaptic vesicle docking involved in exocytosis (GO:0016081)4.61119356
14protein localization to synapse (GO:0035418)4.40189767
15exploration behavior (GO:0035640)4.37639711
16cellular potassium ion homeostasis (GO:0030007)4.34158461
17regulation of neuronal synaptic plasticity (GO:0048168)4.30404375
18regulation of synapse structural plasticity (GO:0051823)4.27050650
19sodium ion export (GO:0071436)4.24266104
20layer formation in cerebral cortex (GO:0021819)4.22564687
21regulation of synaptic vesicle transport (GO:1902803)4.20691379
22regulation of long-term neuronal synaptic plasticity (GO:0048169)4.15501263
23regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.03420516
24glutamate receptor signaling pathway (GO:0007215)4.03385347
25proline transport (GO:0015824)4.01639790
26neurotransmitter secretion (GO:0007269)3.95922166
27synaptic transmission, glutamatergic (GO:0035249)3.92595922
28dendritic spine morphogenesis (GO:0060997)3.82574790
29neuron cell-cell adhesion (GO:0007158)3.75658438
30long-term memory (GO:0007616)3.75167303
31amino acid import (GO:0043090)3.70859128
32neuronal action potential propagation (GO:0019227)3.66465775
33positive regulation of synapse maturation (GO:0090129)3.60930602
34regulation of excitatory postsynaptic membrane potential (GO:0060079)3.59804342
35cytoskeletal anchoring at plasma membrane (GO:0007016)3.59209374
36membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.58754679
37regulation of synaptic plasticity (GO:0048167)3.57315712
38cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.55890233
39gamma-aminobutyric acid transport (GO:0015812)3.54530323
40neuron-neuron synaptic transmission (GO:0007270)3.53343581
41activation of protein kinase A activity (GO:0034199)3.50857803
42neurotransmitter-gated ion channel clustering (GO:0072578)3.47904574
43positive regulation of membrane potential (GO:0045838)3.47002893
44synaptic vesicle endocytosis (GO:0048488)3.46992667
45regulation of ARF protein signal transduction (GO:0032012)3.45772804
46cell communication by electrical coupling (GO:0010644)3.44651666
47regulation of postsynaptic membrane potential (GO:0060078)3.39808361
48G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.39602696
49dendrite morphogenesis (GO:0048813)3.37630019
50neuron recognition (GO:0008038)3.34284725
51L-amino acid import (GO:0043092)3.32246934
52regulation of dendritic spine morphogenesis (GO:0061001)3.31892042
53long-term synaptic potentiation (GO:0060291)3.29199568
54cerebellar granule cell differentiation (GO:0021707)3.26229396
55axonal fasciculation (GO:0007413)3.23834251
56gamma-aminobutyric acid signaling pathway (GO:0007214)3.22578157
57vesicle transport along microtubule (GO:0047496)3.21794389
58neurotransmitter transport (GO:0006836)3.18856831
59* neuromuscular process controlling balance (GO:0050885)3.18099423
60positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.17364477
61protein localization to endosome (GO:0036010)3.15402434
62regulation of neurotransmitter secretion (GO:0046928)3.11466243
63cellular sodium ion homeostasis (GO:0006883)3.10597899
64transmission of nerve impulse (GO:0019226)3.10435049
65cerebellar Purkinje cell differentiation (GO:0021702)3.08988415
66negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.08199272
67regulation of vesicle fusion (GO:0031338)3.07569776
68response to auditory stimulus (GO:0010996)3.05937596
69positive regulation of synaptic transmission, GABAergic (GO:0032230)3.03713520
70regulation of synaptic transmission, glutamatergic (GO:0051966)3.03249689
71innervation (GO:0060384)3.00593568
72dendritic spine organization (GO:0097061)3.00356648
73positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.00280716
74membrane depolarization during action potential (GO:0086010)2.99390593
75glycine transport (GO:0015816)2.99357226
76regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.98675093
77positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.96185161
78neuromuscular process controlling posture (GO:0050884)2.95068877
79behavioral fear response (GO:0001662)2.94832549
80behavioral defense response (GO:0002209)2.94832549
81potassium ion import (GO:0010107)2.94105740
82membrane depolarization (GO:0051899)2.93749232
83establishment of nucleus localization (GO:0040023)2.93671407
84adenosine receptor signaling pathway (GO:0001973)2.93628185
85positive regulation of dendritic spine morphogenesis (GO:0061003)2.93326248
86response to histamine (GO:0034776)2.91774343
87regulation of neurotransmitter levels (GO:0001505)2.90789785
88nerve growth factor signaling pathway (GO:0038180)2.90742874
89G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.86592187
90positive regulation of neurotransmitter secretion (GO:0001956)2.84380162
91regulation of synaptic transmission (GO:0050804)2.84042454
92regulation of neurotransmitter transport (GO:0051588)2.82833228
93potassium ion homeostasis (GO:0055075)2.82349867
94positive regulation of fibroblast migration (GO:0010763)2.82241459
95learning (GO:0007612)2.81924750
96positive regulation of dendritic spine development (GO:0060999)2.81767435
97regulation of dendritic spine development (GO:0060998)2.81533019
98chemosensory behavior (GO:0007635)2.80300888
99positive regulation of synaptic transmission (GO:0050806)2.79681315
100long term synaptic depression (GO:0060292)2.75282009
101regulation of clathrin-mediated endocytosis (GO:2000369)2.74881287
102positive regulation of Rap GTPase activity (GO:0032854)2.74340105
103neuronal ion channel clustering (GO:0045161)2.72840441
104fear response (GO:0042596)2.72300096
105alanine transport (GO:0032328)2.72134918
106synaptic transmission (GO:0007268)2.72097710
107negative regulation of synaptic transmission, GABAergic (GO:0032229)2.71944019
108macrophage activation involved in immune response (GO:0002281)2.68927273
109barbed-end actin filament capping (GO:0051016)2.63949213
110signal complex assembly (GO:0007172)2.62654361
111positive regulation of neurotransmitter transport (GO:0051590)2.61163060
112negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.54100395
113negative regulation of dendrite morphogenesis (GO:0050774)2.52515073
114negative regulation of erythrocyte differentiation (GO:0045647)2.51188241
115regulation of early endosome to late endosome transport (GO:2000641)2.50801261
116positive regulation of protein dephosphorylation (GO:0035307)2.46793293
117mannose metabolic process (GO:0006013)2.44720588
118regulation of ARF GTPase activity (GO:0032312)2.43190773
119regulation of Rap GTPase activity (GO:0032317)2.42118430
120cell-cell junction maintenance (GO:0045217)2.42035518
121regulation of T-helper 2 cell differentiation (GO:0045628)2.40618245
122negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.38506827
123negative regulation of cell killing (GO:0031342)2.38506827
124positive regulation of cellular amide metabolic process (GO:0034250)2.38141982
125regulation of voltage-gated calcium channel activity (GO:1901385)2.37790868
126cortical actin cytoskeleton organization (GO:0030866)2.34279937
127mating behavior (GO:0007617)2.33490087
128regulation of beta-amyloid formation (GO:1902003)2.33026214
129regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.26517832
130cellular response to catecholamine stimulus (GO:0071870)2.22995152
131cellular response to monoamine stimulus (GO:0071868)2.22995152
132regulation of synapse maturation (GO:0090128)2.20299748
133acidic amino acid transport (GO:0015800)2.19537737
134dopamine receptor signaling pathway (GO:0007212)2.19321875
135positive regulation of macrophage cytokine production (GO:0060907)2.17879033
136regulation of amyloid precursor protein catabolic process (GO:1902991)2.15618137
137stress fiber assembly (GO:0043149)2.13727524
138response to peptidoglycan (GO:0032494)2.13566340
139central nervous system myelination (GO:0022010)2.12745270
140axon ensheathment in central nervous system (GO:0032291)2.12745270
141peptidyl-tyrosine autophosphorylation (GO:0038083)2.11466928
142cortical cytoskeleton organization (GO:0030865)2.08905624
143response to muramyl dipeptide (GO:0032495)2.08579297

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.83519986
2SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.89192009
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.88152158
4GBX2_23144817_ChIP-Seq_PC3_Human2.86136987
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.84344628
6DROSHA_22980978_ChIP-Seq_HELA_Human2.79462358
7* RARB_27405468_Chip-Seq_BRAIN_Mouse2.68560154
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.59136050
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.59136050
10REST_21632747_ChIP-Seq_MESCs_Mouse2.58455329
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.49193041
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.45238319
13MTF2_20144788_ChIP-Seq_MESCs_Mouse2.43726509
14SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.43237773
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.37342226
16IKZF1_21737484_ChIP-ChIP_HCT116_Human2.35102059
17LXR_22292898_ChIP-Seq_THP-1_Human2.32957285
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.26668542
19EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.25450045
20SUZ12_27294783_Chip-Seq_ESCs_Mouse2.17050765
21MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.15072433
22EZH2_27304074_Chip-Seq_ESCs_Mouse2.14400872
23EZH2_27294783_Chip-Seq_ESCs_Mouse2.12671410
24* RNF2_27304074_Chip-Seq_ESCs_Mouse2.09947486
25REST_18959480_ChIP-ChIP_MESCs_Mouse2.09226186
26EED_16625203_ChIP-ChIP_MESCs_Mouse2.00392282
27ESR2_21235772_ChIP-Seq_MCF-7_Human1.95331394
28NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.87753615
29CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.86915478
30NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.86853845
31ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.73370464
32AR_21572438_ChIP-Seq_LNCaP_Human1.68520453
33RARG_19884340_ChIP-ChIP_MEFs_Mouse1.60290985
34TCF7_22412390_ChIP-Seq_EML_Mouse1.59392984
35VDR_21846776_ChIP-Seq_THP-1_Human1.58896797
36NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.55154745
37* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.53065394
38SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.50871779
39VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.48662157
40ERG_21242973_ChIP-ChIP_JURKAT_Human1.44503837
41SMAD_19615063_ChIP-ChIP_OVARY_Human1.43365628
42* ELK3_25401928_ChIP-Seq_HUVEC_Human1.42694178
43* KDM2B_26808549_Chip-Seq_K562_Human1.42574881
44SMAD4_21799915_ChIP-Seq_A2780_Human1.42218369
45SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.41540728
46* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.40941044
47WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.34125443
48CTBP2_25329375_ChIP-Seq_LNCAP_Human1.33360088
49* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.33120889
50TP63_17297297_ChIP-ChIP_HaCaT_Human1.33096942
51DNAJC2_21179169_ChIP-ChIP_NT2_Human1.31300847
52* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.31249480
53RACK7_27058665_Chip-Seq_MCF-7_Human1.30898222
54RING1B_27294783_Chip-Seq_ESCs_Mouse1.30436820
55GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.29596991
56VDR_24763502_ChIP-Seq_THP-1_Human1.27907923
57* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.27587603
58* SMC4_20622854_ChIP-Seq_HELA_Human1.27373176
59NR3C1_23031785_ChIP-Seq_PC12_Mouse1.27154611
60PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.26861691
61GATA1_19941827_ChIP-Seq_MEL_Mouse1.26720585
62* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.26486308
63CTBP1_25329375_ChIP-Seq_LNCAP_Human1.24988225
64RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.24771559
65SOX2_21211035_ChIP-Seq_LN229_Gbm1.24648901
66GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.23966035
67ZNF217_24962896_ChIP-Seq_MCF-7_Human1.23792810
68* IRF8_27001747_Chip-Seq_BMDM_Mouse1.23681653
69SPI1_23127762_ChIP-Seq_K562_Human1.22812256
70* AR_19668381_ChIP-Seq_PC3_Human1.22555004
71* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.20988977
72E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.19700441
73SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.18678269
74* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.15147923
75ZNF274_21170338_ChIP-Seq_K562_Hela1.15003161
76CDX2_19796622_ChIP-Seq_MESCs_Mouse1.14852360
77AR_25329375_ChIP-Seq_VCAP_Human1.14214663
78NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.13857092
79SMAD3_21741376_ChIP-Seq_EPCs_Human1.13236589
80* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.11575271
81SRY_22984422_ChIP-ChIP_TESTIS_Rat1.11425869
82THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.11384123
83KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.10113688
84PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.09546866
85RING1B_27294783_Chip-Seq_NPCs_Mouse1.09072591
86AHR_22903824_ChIP-Seq_MCF-7_Human1.08889592
87ZFP281_27345836_Chip-Seq_ESCs_Mouse1.07920231
88STAT3_23295773_ChIP-Seq_U87_Human1.07640456
89TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.07184419
90ARNT_22903824_ChIP-Seq_MCF-7_Human1.06899569
91BP1_19119308_ChIP-ChIP_Hs578T_Human1.06860984
92CTCF_27219007_Chip-Seq_ERYTHROID_Human1.06116462
93STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.05489120
94RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.05401906
95P53_22127205_ChIP-Seq_FIBROBLAST_Human1.05208341
96TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.04969702
97SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.04943576
98* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.04774040
99* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.03933265
100RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.03740917
101IRF8_22096565_ChIP-ChIP_GC-B_Human1.03476565
102Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.03438520
103TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.02767023
104P68_20966046_ChIP-Seq_HELA_Human1.02726542
105TP53_16413492_ChIP-PET_HCT116_Human1.01995186
106CREB1_26743006_Chip-Seq_LNCaP_Human1.01073772
107* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.00977377
108SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00953005
109* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.00862680
110SMAD3_21741376_ChIP-Seq_HESCs_Human1.00457655
111SA1_27219007_Chip-Seq_ERYTHROID_Human1.00322165
112IRF8_21731497_ChIP-ChIP_J774_Mouse0.99484802
113* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.98938447
114RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.98351296
115P300_19829295_ChIP-Seq_ESCs_Human0.98023391
116STAT6_21828071_ChIP-Seq_BEAS2B_Human0.97729248
117MYB_21317192_ChIP-Seq_ERMYB_Mouse0.97554727
118SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.96494647
119OCT4_19829295_ChIP-Seq_ESCs_Human0.94682336
120SMAD3_21741376_ChIP-Seq_ESCs_Human0.94280749
121MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.94161930
122TCF4_23295773_ChIP-Seq_U87_Human0.93421434
123NFIB_24661679_ChIP-Seq_LUNG_Mouse0.92322646
124* RXR_22108803_ChIP-Seq_LS180_Human0.91402186
125TOP2B_26459242_ChIP-Seq_MCF-7_Human0.91283593
126DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.91257605
127* SMAD4_21741376_ChIP-Seq_HESCs_Human0.91234950
128* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.91200569
129MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.91064168
130CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.90253490
131ESR1_21235772_ChIP-Seq_MCF-7_Human0.90096311
132MYC_22102868_ChIP-Seq_BL_Human0.89280704
133TBX20_22080862_ChIP-Seq_HEART_Mouse0.89263768
134TBX20_22328084_ChIP-Seq_HEART_Mouse0.89263768
135PRDM14_20953172_ChIP-Seq_ESCs_Human0.89238582
136TET1_21451524_ChIP-Seq_MESCs_Mouse0.88993890
137* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.87773097
138PIAS1_25552417_ChIP-Seq_VCAP_Human0.87121707
139TET1_21490601_ChIP-Seq_MESCs_Mouse0.85915714
140NR3C1_21868756_ChIP-Seq_MCF10A_Human0.85886641
141* ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.85811157
142CTNNB1_20460455_ChIP-Seq_HCT116_Human0.85443389
143GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84236639
144AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.83764685
145* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.83141136
146* KDM2B_26808549_Chip-Seq_DND41_Human0.82729126
147* KDM2B_26808549_Chip-Seq_JURKAT_Human0.81197256
148* CTCF_27219007_Chip-Seq_Bcells_Human0.80090968
149TAF15_26573619_Chip-Seq_HEK293_Human0.79177122
150BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.78938859
151TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.78907700

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.52527775
2MP0003880_abnormal_central_pattern4.68212489
3MP0003635_abnormal_synaptic_transmissio4.25360874
4MP0004270_analgesia3.75296874
5MP0002063_abnormal_learning/memory/cond3.41819191
6MP0009745_abnormal_behavioral_response3.31374572
7MP0002064_seizures3.15805202
8MP0009046_muscle_twitch2.85868211
9MP0005423_abnormal_somatic_nervous2.80917954
10MP0005058_abnormal_lysosome_morphology2.78301287
11MP0001968_abnormal_touch/_nociception2.77505105
12MP0002572_abnormal_emotion/affect_behav2.70756331
13MP0004858_abnormal_nervous_system2.59821740
14MP0002734_abnormal_mechanical_nocicepti2.45949505
15MP0001501_abnormal_sleep_pattern2.37953410
16MP0001486_abnormal_startle_reflex2.37301852
17MP0000569_abnormal_digit_pigmentation2.30859435
18MP0002272_abnormal_nervous_system2.29547606
19MP0002822_catalepsy2.22893717
20MP0002735_abnormal_chemical_nociception2.19128282
21MP0001440_abnormal_grooming_behavior2.15161427
22MP0002736_abnormal_nociception_after2.08454075
23MP0002733_abnormal_thermal_nociception2.00586583
24MP0003329_amyloid_beta_deposits1.98799661
25MP0009780_abnormal_chondrocyte_physiolo1.97368519
26MP0003705_abnormal_hypodermis_morpholog1.96192710
27MP0003436_decreased_susceptibility_to1.93777724
28MP0002909_abnormal_adrenal_gland1.92823709
29MP0001970_abnormal_pain_threshold1.92083449
30MP0008569_lethality_at_weaning1.91396368
31MP0004811_abnormal_neuron_physiology1.86433520
32MP0003300_gastrointestinal_ulcer1.79313805
33MP0002067_abnormal_sensory_capabilities1.77058323
34MP0000778_abnormal_nervous_system1.75541581
35MP0002184_abnormal_innervation1.65897245
36MP0006082_CNS_inflammation1.62491836
37MP0009840_abnormal_foam_cell1.62272808
38MP0002557_abnormal_social/conspecific_i1.59030381
39MP0003879_abnormal_hair_cell1.53910509
40MP0004510_myositis1.52287196
41MP0000955_abnormal_spinal_cord1.50993159
42MP0003191_abnormal_cellular_cholesterol1.49552415
43MP0003172_abnormal_lysosome_physiology1.49132447
44MP0005409_darkened_coat_color1.48881204
45MP0004885_abnormal_endolymph1.46983258
46MP0004924_abnormal_behavior1.45263555
47MP0005386_behavior/neurological_phenoty1.45263555
48MP0003075_altered_response_to1.44888154
49MP0003787_abnormal_imprinting1.43865845
50MP0003633_abnormal_nervous_system1.43561780
51MP0002882_abnormal_neuron_morphology1.40304870
52MP0003091_abnormal_cell_migration1.38310678
53MP0001984_abnormal_olfaction1.37847915
54MP0009278_abnormal_bone_marrow1.35383187
55MP0001958_emphysema1.33975172
56MP0002066_abnormal_motor_capabilities/c1.32461580
57MP0002419_abnormal_innate_immunity1.30838199
58MP0002998_abnormal_bone_remodeling1.29726374
59MP0008961_abnormal_basal_metabolism1.28292802
60MP0008260_abnormal_autophagy1.26285229
61MP0005645_abnormal_hypothalamus_physiol1.24742850
62MP0001502_abnormal_circadian_rhythm1.24217440
63MP0005646_abnormal_pituitary_gland1.22897293
64MP0000604_amyloidosis1.22333885
65MP0003724_increased_susceptibility_to1.21980884
66MP0003303_peritoneal_inflammation1.21821400
67MP0001533_abnormal_skeleton_physiology1.21274475
68MP0004947_skin_inflammation1.18677348
69MP0006276_abnormal_autonomic_nervous1.18412146
70MP0003631_nervous_system_phenotype1.15215075
71MP0005167_abnormal_blood-brain_barrier1.14827477
72MP0005387_immune_system_phenotype1.13577674
73MP0001790_abnormal_immune_system1.13577674
74MP0003283_abnormal_digestive_organ1.11040311
75MP0005000_abnormal_immune_tolerance1.09230993
76MP0000751_myopathy1.07038008
77* MP0002152_abnormal_brain_morphology1.06920493
78MP0005451_abnormal_body_composition1.05046792
79MP0005025_abnormal_response_to1.04741643
80MP0000343_altered_response_to1.02871880
81MP0001849_ear_inflammation1.02867711
82MP0003279_aneurysm1.01611565
83MP0010234_abnormal_vibrissa_follicle1.00531498
84MP0001348_abnormal_lacrimal_gland1.00332868
85MP0002148_abnormal_hypersensitivity_rea0.98854032
86MP0003453_abnormal_keratinocyte_physiol0.95767954
87MP0002090_abnormal_vision0.93233114
88MP0003183_abnormal_peptide_metabolism0.92673016
89MP0010386_abnormal_urinary_bladder0.92339982
90* MP0003634_abnormal_glial_cell0.90945905
91MP0002069_abnormal_eating/drinking_beha0.90277622
92MP0008004_abnormal_stomach_pH0.89917866
93MP0008874_decreased_physiological_sensi0.88734075
94MP0002229_neurodegeneration0.87521571
95MP0001177_atelectasis0.86060746
96MP0003122_maternal_imprinting0.84877264
97MP0005671_abnormal_response_to0.84737767
98MP0001835_abnormal_antigen_presentation0.82742001
99MP0001905_abnormal_dopamine_level0.82019372
100MP0005165_increased_susceptibility_to0.81316926
101MP0003632_abnormal_nervous_system0.79048187
102* MP0003690_abnormal_glial_cell0.78718394
103MP0004142_abnormal_muscle_tone0.76774880
104MP0002877_abnormal_melanocyte_morpholog0.76481519
105MP0005257_abnormal_intraocular_pressure0.76063940
106MP0002452_abnormal_antigen_presenting0.75540401
107MP0003566_abnormal_cell_adhesion0.75212980
108MP0000685_abnormal_immune_system0.75130579
109MP0000920_abnormal_myelination0.73209391
110MP0002723_abnormal_immune_serum0.72485913
111MP0004085_abnormal_heartbeat0.70456240
112MP0009785_altered_susceptibility_to0.70382345
113MP0005535_abnormal_body_temperature0.70044557
114MP0002133_abnormal_respiratory_system0.69943668
115MP0005388_respiratory_system_phenotype0.69943668
116MP0005076_abnormal_cell_differentiation0.67825620
117MP0000015_abnormal_ear_pigmentation0.67791888
118MP0008872_abnormal_physiological_respon0.67696780
119MP0005166_decreased_susceptibility_to0.67432182
120MP0001963_abnormal_hearing_physiology0.67411575
121MP0002420_abnormal_adaptive_immunity0.66735131
122MP0003828_pulmonary_edema0.66476859
123MP0001819_abnormal_immune_cell0.66257408
124MP0001299_abnormal_eye_distance/0.63966906
125MP0005499_abnormal_olfactory_system0.63812988
126MP0005394_taste/olfaction_phenotype0.63812988
127MP0000747_muscle_weakness0.63293167
128MP0003045_fibrosis0.62980277
129MP0004742_abnormal_vestibular_system0.62971333
130MP0005551_abnormal_eye_electrophysiolog0.62664408
131MP0005623_abnormal_meninges_morphology0.62562823
132MP0004145_abnormal_muscle_electrophysio0.58502366
133MP0004233_abnormal_muscle_weight0.58113146
134MP0002752_abnormal_somatic_nervous0.57725658
135MP0000013_abnormal_adipose_tissue0.57491044
136MP0004484_altered_response_of0.56279994
137MP0003137_abnormal_impulse_conducting0.54851803
138MP0001664_abnormal_digestion0.54748777
139MP0005310_abnormal_salivary_gland0.52080661
140MP0004130_abnormal_muscle_cell0.51794402
141* MP0003861_abnormal_nervous_system0.51378446
142MP0010769_abnormal_survival0.51112991
143MP0002089_abnormal_postnatal_growth/wei0.50452718
144MP0001943_abnormal_respiration0.49757775
145MP0001485_abnormal_pinna_reflex0.49444244
146MP0000631_abnormal_neuroendocrine_gland0.47850464
147MP0010768_mortality/aging0.46648861

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.77414135
2Myokymia (HP:0002411)6.37230668
3Focal seizures (HP:0007359)5.35608722
4Visual hallucinations (HP:0002367)5.00143994
5Supranuclear gaze palsy (HP:0000605)4.32514915
6Epileptic encephalopathy (HP:0200134)4.30943791
7Progressive cerebellar ataxia (HP:0002073)4.06680499
8Atonic seizures (HP:0010819)3.97739003
9Febrile seizures (HP:0002373)3.89863501
10Abnormality of glycolipid metabolism (HP:0010969)3.83453246
11Abnormality of liposaccharide metabolism (HP:0010968)3.83453246
12Abnormality of glycosphingolipid metabolism (HP:0004343)3.83453246
13Absence seizures (HP:0002121)3.77931270
14Action tremor (HP:0002345)3.72434205
15Dialeptic seizures (HP:0011146)3.50024069
16Generalized tonic-clonic seizures (HP:0002069)3.48553206
17Papilledema (HP:0001085)3.44782706
18Mutism (HP:0002300)3.37443680
19Ankle clonus (HP:0011448)3.24062768
20Postural instability (HP:0002172)3.20001712
21Genetic anticipation (HP:0003743)3.17994136
22Depression (HP:0000716)3.17654804
23Impaired vibration sensation in the lower limbs (HP:0002166)3.11320879
24Dysostosis multiplex (HP:0000943)3.08759384
25Urinary bladder sphincter dysfunction (HP:0002839)3.07120543
26Dysmetria (HP:0001310)2.99882189
27Abnormality of the lower motor neuron (HP:0002366)2.95008009
28Truncal ataxia (HP:0002078)2.90611534
29Hemiplegia (HP:0002301)2.89133693
30Broad-based gait (HP:0002136)2.89117982
31Abnormal eating behavior (HP:0100738)2.87558490
32Dysdiadochokinesis (HP:0002075)2.87049601
33Poor eye contact (HP:0000817)2.83601375
34Gaze-evoked nystagmus (HP:0000640)2.80740240
35Diplopia (HP:0000651)2.79875541
36Abnormality of binocular vision (HP:0011514)2.79875541
37Abnormal social behavior (HP:0012433)2.73671687
38Impaired social interactions (HP:0000735)2.73671687
39Impaired smooth pursuit (HP:0007772)2.67997076
40Amblyopia (HP:0000646)2.67499992
41Ventricular fibrillation (HP:0001663)2.65233086
42Loss of speech (HP:0002371)2.64103577
43Hemiparesis (HP:0001269)2.60702265
44Systemic lupus erythematosus (HP:0002725)2.60389914
45Axonal loss (HP:0003447)2.59682374
46Stereotypic behavior (HP:0000733)2.58525282
47Urinary urgency (HP:0000012)2.57142471
48Cerebral inclusion bodies (HP:0100314)2.56315789
49Drooling (HP:0002307)2.53018693
50Excessive salivation (HP:0003781)2.53018693
51Neurofibrillary tangles (HP:0002185)2.52829419
52Eczematoid dermatitis (HP:0000976)2.52543173
53Pointed chin (HP:0000307)2.49634618
54Anxiety (HP:0000739)2.48195553
55Increased neuronal autofluorescent lipopigment (HP:0002074)2.46152688
56Cerebral aneurysm (HP:0004944)2.45188354
57Abnormality of polysaccharide metabolism (HP:0011012)2.45173114
58Abnormality of glycosaminoglycan metabolism (HP:0004371)2.45173114
59Abnormality of mucopolysaccharide metabolism (HP:0011020)2.45173114
60Nuclear cataract (HP:0100018)2.43177240
61Mucopolysacchariduria (HP:0008155)2.42448042
62Urinary glycosaminoglycan excretion (HP:0003541)2.42448042
63Peripheral hypomyelination (HP:0007182)2.42343385
64Abnormality of macrophages (HP:0004311)2.37209187
65Apathy (HP:0000741)2.36802696
66Megalencephaly (HP:0001355)2.35686277
67Insomnia (HP:0100785)2.33047942
68Abnormality of ocular smooth pursuit (HP:0000617)2.31879934
69Bradykinesia (HP:0002067)2.29412093
70Inappropriate behavior (HP:0000719)2.28835102
71Intention tremor (HP:0002080)2.27957959
72Spastic gait (HP:0002064)2.27794476
73Torticollis (HP:0000473)2.26760837
74Scanning speech (HP:0002168)2.22661162
75Neuronal loss in central nervous system (HP:0002529)2.20265907
76Annular pancreas (HP:0001734)2.19662372
77Distal upper limb amyotrophy (HP:0007149)2.19119765
78Upper limb amyotrophy (HP:0009129)2.19119765
79Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.18722699
80Amyloidosis (HP:0011034)2.18483101
81Epileptiform EEG discharges (HP:0011182)2.17270039
82Disinhibition (HP:0000734)2.16859632
83Progressive inability to walk (HP:0002505)2.14215175
84Dysmetric saccades (HP:0000641)2.11901263
85Diminished motivation (HP:0000745)2.10301507
86Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.05262098
87Absent speech (HP:0001344)2.04519387
88Fetal akinesia sequence (HP:0001989)2.04482970
89Rapidly progressive (HP:0003678)2.03611312
90Focal dystonia (HP:0004373)2.03473503
91Tetraplegia (HP:0002445)2.03171642
92Lower limb amyotrophy (HP:0007210)2.01307045
93Lower limb muscle weakness (HP:0007340)2.01035265
94Ocular albinism (HP:0001107)2.00574781
95EEG with generalized epileptiform discharges (HP:0011198)2.00442150
96Agitation (HP:0000713)1.99421920
97Termporal pattern (HP:0011008)1.99247229
98Insidious onset (HP:0003587)1.99247229
99Hyperventilation (HP:0002883)1.96254687
100Bundle branch block (HP:0011710)1.94883470
101Polyphagia (HP:0002591)1.93806955
102Impaired vibratory sensation (HP:0002495)1.93767881
103Ankyloglossia (HP:0010296)1.93739430
104Interstitial pulmonary disease (HP:0006530)1.93390353
105Slow saccadic eye movements (HP:0000514)1.93266913
106Obstructive sleep apnea (HP:0002870)1.93056627
107Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.92564036
108Recurrent bacterial skin infections (HP:0005406)1.91883761
109Status epilepticus (HP:0002133)1.90624943
110Generalized myoclonic seizures (HP:0002123)1.89194214
111Hypsarrhythmia (HP:0002521)1.87812558
112Hyperacusis (HP:0010780)1.87386227
113Hand muscle atrophy (HP:0009130)1.85171072
114Segmental peripheral demyelination/remyelination (HP:0003481)1.84090071
115Akinesia (HP:0002304)1.83045855
116Recurrent abscess formation (HP:0002722)1.82595160
117Global brain atrophy (HP:0002283)1.82562554
118Onion bulb formation (HP:0003383)1.82346086
119Lower limb asymmetry (HP:0100559)1.80439690
120Increased cerebral lipofuscin (HP:0011813)1.80373847
121Hyperparathyroidism (HP:0000843)1.80007994
122Memory impairment (HP:0002354)1.78657055
123Broad face (HP:0000283)1.78629499
124Cellulitis (HP:0100658)1.78334979
125Abnormality of saccadic eye movements (HP:0000570)1.77766168
126Asymmetric septal hypertrophy (HP:0001670)1.77217258
127Psychosis (HP:0000709)1.76058804
128Abnormality of salivation (HP:0100755)1.75461378
129Abnormality of the periventricular white matter (HP:0002518)1.74834676
130Incomplete penetrance (HP:0003829)1.74833749
131Increased circulating renin level (HP:0000848)1.74422192
132Vacuolated lymphocytes (HP:0001922)1.74336747
133Hypoventilation (HP:0002791)1.73664948
134Rigidity (HP:0002063)1.73615038
135Distal lower limb amyotrophy (HP:0008944)1.73349774
136Abnormal EKG (HP:0003115)1.71419529
137Personality changes (HP:0000751)1.71125084
138Craniofacial dystonia (HP:0012179)1.70404039
139Thin bony cortex (HP:0002753)1.69645058
140Iris hypopigmentation (HP:0007730)1.69224564
141Macroorchidism (HP:0000053)1.68463408
142Turricephaly (HP:0000262)1.67753692
143Dementia (HP:0000726)1.66903073
144Spastic tetraparesis (HP:0001285)1.66177853
145Amyotrophic lateral sclerosis (HP:0007354)1.65982347
146Aqueductal stenosis (HP:0002410)1.65487515
147Glomerulonephritis (HP:0000099)1.64987986
148Gingivitis (HP:0000230)1.63431762
149Decreased motor nerve conduction velocity (HP:0003431)1.62067116
150Distal sensory impairment (HP:0002936)1.62010895
151Vertebral compression fractures (HP:0002953)1.61906863
152Clonus (HP:0002169)1.61523845

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.47786957
2MAP3K94.26995307
3EPHA44.26288798
4MARK13.00463056
5KSR22.67159749
6DAPK22.57524496
7MAP3K42.52755233
8RIPK42.52405571
9MINK12.52264808
10PAK62.45081336
11PRKD32.22642856
12NTRK22.18784185
13CAMKK12.03869019
14MAP2K71.87462471
15KSR11.82283802
16SIK21.81715059
17NTRK11.77609015
18ERN11.74687900
19MAP3K131.72896335
20FES1.67580864
21CDK51.58283653
22MAP3K21.56046502
23DAPK11.54475443
24STK381.48313558
25MAP2K41.45005694
26MAP3K121.41329640
27MAP3K111.38098611
28ARAF1.36566215
29BLK1.32606909
30TYRO31.31924747
31TNIK1.30727964
32PLK21.30560102
33TAOK11.26938275
34IRAK31.25873001
35PRPF4B1.18523426
36MARK21.10412492
37MAPK131.06563944
38GRK51.05434802
39PRKCG1.04351052
40PRKCH1.02994218
41ALK1.02216854
42TESK11.01668330
43MAPK121.01497040
44RIPK10.99482196
45CAMK10.98180093
46RET0.98085443
47UHMK10.94842142
48JAK10.93804123
49TAOK20.93268827
50SIK10.93025727
51CAMKK20.92362304
52TYK20.91465149
53RAF10.91079450
54STK110.90397032
55LMTK20.86833305
56PHKG10.86195589
57PHKG20.86195589
58MAP4K10.82008148
59SGK30.81705716
60CDK150.81078907
61CAMK1G0.81046779
62CDK180.80911503
63CAMK2A0.80695238
64IRAK20.80410063
65PTK2B0.79699773
66PDK10.79464561
67MAP3K10.77774495
68CDK190.77612711
69SCYL20.76601599
70CDK140.75607968
71SGK10.73940483
72MAP3K70.73901434
73FGR0.73269726
74LATS20.72796091
75SGK4940.72444635
76SGK2230.72444635
77PDPK10.71967698
78CAMK1D0.71720605
79CAMK2B0.71348971
80EPHB10.71008252
81PAK30.70408865
82ZAP700.70103072
83TTN0.69725711
84CDK11A0.69711355
85SGK20.69587690
86TBK10.69560739
87DMPK0.69144916
88MAP3K30.68061125
89CSK0.67910211
90MAP3K140.65613818
91LIMK10.65453744
92MAP2K30.65453380
93ROCK20.63689952
94SMG10.62695931
95JAK20.62381844
96PNCK0.60694410
97DYRK1A0.60589079
98FYN0.60532618
99CSNK1G20.60453874
100NEK60.60098661
101CDC42BPA0.59060445
102PRKG20.57487375
103EEF2K0.57401602
104MAPK70.57401252
105TGFBR20.54565422
106BMX0.53195806
107CSF1R0.52405027
108RPS6KA30.50504469
109PRKCZ0.49806750
110CAMK2G0.47201429
111TRIB30.47157996
112MAPK100.46502863
113RPS6KA20.46272080
114CAMK40.46166049
115SYK0.45867774
116PDGFRB0.43818305
117IRAK40.43394063
118TNK20.42734851
119DDR20.41541346
120FER0.40468935
121BMPR20.39966289
122PRKCE0.39417178
123PDGFRA0.38258866
124MAP2K10.37381100
125ICK0.36488991
126HCK0.32613858
127CAMK2D0.32028305
128DAPK30.31384473
129PRKD20.31085635
130SRC0.30678268
131PINK10.29949419
132PKN20.29646117
133CASK0.29062909
134PRKCB0.28372426
135MOS0.27962595

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.11617424
2Synaptic vesicle cycle_Homo sapiens_hsa047212.89522864
3Olfactory transduction_Homo sapiens_hsa047402.53592646
4Circadian entrainment_Homo sapiens_hsa047132.47342154
5Long-term potentiation_Homo sapiens_hsa047202.43683744
6GABAergic synapse_Homo sapiens_hsa047272.33986938
7Glutamatergic synapse_Homo sapiens_hsa047242.31518047
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.29173663
9Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.20592244
10Morphine addiction_Homo sapiens_hsa050322.18435227
11Amphetamine addiction_Homo sapiens_hsa050312.04721204
12Salivary secretion_Homo sapiens_hsa049702.01458811
13Dopaminergic synapse_Homo sapiens_hsa047281.87488304
14Insulin secretion_Homo sapiens_hsa049111.85932637
15Gastric acid secretion_Homo sapiens_hsa049711.82313742
16Cholinergic synapse_Homo sapiens_hsa047251.80141722
17Aldosterone synthesis and secretion_Homo sapiens_hsa049251.71908975
18Other glycan degradation_Homo sapiens_hsa005111.68612703
19Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.58469179
20Oxytocin signaling pathway_Homo sapiens_hsa049211.58372776
21Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.53158582
22Long-term depression_Homo sapiens_hsa047301.49175201
23GnRH signaling pathway_Homo sapiens_hsa049121.48070982
24Renin secretion_Homo sapiens_hsa049241.47886665
25Type II diabetes mellitus_Homo sapiens_hsa049301.43118935
26Calcium signaling pathway_Homo sapiens_hsa040201.39796514
27Cocaine addiction_Homo sapiens_hsa050301.37650998
28Lysosome_Homo sapiens_hsa041421.35835963
29Serotonergic synapse_Homo sapiens_hsa047261.35587609
30Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.34602766
31Taste transduction_Homo sapiens_hsa047421.33997576
32Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.30227949
33Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.28517421
34Glioma_Homo sapiens_hsa052141.26489975
35Phosphatidylinositol signaling system_Homo sapiens_hsa040701.25084897
36cAMP signaling pathway_Homo sapiens_hsa040241.23550135
37Gap junction_Homo sapiens_hsa045401.21906932
38Collecting duct acid secretion_Homo sapiens_hsa049661.21204949
39Estrogen signaling pathway_Homo sapiens_hsa049151.17677491
40Glycosaminoglycan degradation_Homo sapiens_hsa005311.16023986
41Toll-like receptor signaling pathway_Homo sapiens_hsa046201.14784510
42Leishmaniasis_Homo sapiens_hsa051401.14110783
43Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.11656155
44Axon guidance_Homo sapiens_hsa043601.07716495
45ErbB signaling pathway_Homo sapiens_hsa040121.02729648
46Dorso-ventral axis formation_Homo sapiens_hsa043201.00954647
47cGMP-PKG signaling pathway_Homo sapiens_hsa040220.99797388
48Carbohydrate digestion and absorption_Homo sapiens_hsa049730.99054905
49Phospholipase D signaling pathway_Homo sapiens_hsa040720.98303725
50Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.96647734
51Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.96062671
52Nitrogen metabolism_Homo sapiens_hsa009100.95967878
53Staphylococcus aureus infection_Homo sapiens_hsa051500.93746641
54Melanogenesis_Homo sapiens_hsa049160.92895769
55Neurotrophin signaling pathway_Homo sapiens_hsa047220.92836791
56VEGF signaling pathway_Homo sapiens_hsa043700.89075186
57Phagosome_Homo sapiens_hsa041450.88921405
58Pertussis_Homo sapiens_hsa051330.87048834
59Vascular smooth muscle contraction_Homo sapiens_hsa042700.85530490
60Pancreatic secretion_Homo sapiens_hsa049720.85156804
61Vibrio cholerae infection_Homo sapiens_hsa051100.83166619
62Choline metabolism in cancer_Homo sapiens_hsa052310.83150298
63AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.82283781
64Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.80583134
65Amoebiasis_Homo sapiens_hsa051460.78882369
66Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.76683852
67Rheumatoid arthritis_Homo sapiens_hsa053230.76637125
68Toxoplasmosis_Homo sapiens_hsa051450.76125309
69MAPK signaling pathway_Homo sapiens_hsa040100.75874891
70mTOR signaling pathway_Homo sapiens_hsa041500.75837872
71Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.75571522
72Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.74730469
73TNF signaling pathway_Homo sapiens_hsa046680.74404573
74Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.74155086
75Thyroid hormone synthesis_Homo sapiens_hsa049180.73819216
76Dilated cardiomyopathy_Homo sapiens_hsa054140.73451184
77Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.72439334
78Thyroid hormone signaling pathway_Homo sapiens_hsa049190.71616411
79Leukocyte transendothelial migration_Homo sapiens_hsa046700.71452760
80Notch signaling pathway_Homo sapiens_hsa043300.70866434
81Sphingolipid signaling pathway_Homo sapiens_hsa040710.69557324
82Oocyte meiosis_Homo sapiens_hsa041140.69273918
83Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.69087584
84Rap1 signaling pathway_Homo sapiens_hsa040150.66993835
85Acute myeloid leukemia_Homo sapiens_hsa052210.66890282
86Endocytosis_Homo sapiens_hsa041440.66154634
87Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.66043658
88Chemokine signaling pathway_Homo sapiens_hsa040620.64712549
89Prolactin signaling pathway_Homo sapiens_hsa049170.64533400
90Chronic myeloid leukemia_Homo sapiens_hsa052200.63807860
91Inositol phosphate metabolism_Homo sapiens_hsa005620.63166394
92Non-small cell lung cancer_Homo sapiens_hsa052230.61687397
93Endometrial cancer_Homo sapiens_hsa052130.61493541
94Ras signaling pathway_Homo sapiens_hsa040140.61045766
95Type I diabetes mellitus_Homo sapiens_hsa049400.60788192
96Malaria_Homo sapiens_hsa051440.57073125
97Hepatitis C_Homo sapiens_hsa051600.56643114
98Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.56621109
99Renal cell carcinoma_Homo sapiens_hsa052110.55039439
100Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.53165967
101African trypanosomiasis_Homo sapiens_hsa051430.49114164
102Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.49063414
103Tuberculosis_Homo sapiens_hsa051520.48177612
104Longevity regulating pathway - mammal_Homo sapiens_hsa042110.47173924
105Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.46865923
106Cardiac muscle contraction_Homo sapiens_hsa042600.46569292
107Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.46261510
108Regulation of actin cytoskeleton_Homo sapiens_hsa048100.45640245
109Colorectal cancer_Homo sapiens_hsa052100.45463178
110Glucagon signaling pathway_Homo sapiens_hsa049220.44441177
111Prion diseases_Homo sapiens_hsa050200.44215278
112Mineral absorption_Homo sapiens_hsa049780.44060777
113Salmonella infection_Homo sapiens_hsa051320.43607964
114Osteoclast differentiation_Homo sapiens_hsa043800.43423970
115Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.43328211
116Bile secretion_Homo sapiens_hsa049760.43151873
117Platelet activation_Homo sapiens_hsa046110.42774582
118Insulin signaling pathway_Homo sapiens_hsa049100.42034289
119B cell receptor signaling pathway_Homo sapiens_hsa046620.41686738
120Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.41264307
121Circadian rhythm_Homo sapiens_hsa047100.41002024
122Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.40599238

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