ABTB1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein with an ankyrin repeat region and two BTB/POZ domains, which are thought to be involved in protein-protein interactions. Expression of this gene is activated by the phosphatase and tensin homolog, a tumor suppressor. Alternate splicing results in three transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.78450474
2negative regulation of cell killing (GO:0031342)5.69252869
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.69252869
4modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.62828806
5positive regulation by organism of defense response of other organism involved in symbiotic interact5.62828806
6modulation by symbiont of host immune response (GO:0052553)5.62828806
7positive regulation by symbiont of host defense response (GO:0052509)5.62828806
8modulation by symbiont of host defense response (GO:0052031)5.62828806
9modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.62828806
10detection of other organism (GO:0098543)5.15707597
11detection of bacterium (GO:0016045)5.03693131
12positive regulation of gamma-delta T cell activation (GO:0046645)5.01071595
13macrophage activation involved in immune response (GO:0002281)4.76289513
14regulation of gamma-delta T cell differentiation (GO:0045586)4.52938079
15negative regulation of lymphocyte mediated immunity (GO:0002707)4.43725774
16regulation of B cell receptor signaling pathway (GO:0050855)4.43354514
17response to peptidoglycan (GO:0032494)4.41912486
18detection of external biotic stimulus (GO:0098581)4.37763372
19killing of cells in other organism involved in symbiotic interaction (GO:0051883)4.37681010
20disruption of cells of other organism involved in symbiotic interaction (GO:0051818)4.37681010
21leukocyte migration involved in inflammatory response (GO:0002523)4.31535944
22negative regulation of interleukin-12 production (GO:0032695)4.13391535
23regulation of gamma-delta T cell activation (GO:0046643)4.07575711
24detection of molecule of bacterial origin (GO:0032490)4.06017335
25protoporphyrinogen IX metabolic process (GO:0046501)4.02008497
26positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.01978256
27regulation of interferon-beta biosynthetic process (GO:0045357)3.99464750
28granulocyte activation (GO:0036230)3.94969089
29negative regulation of leukocyte mediated immunity (GO:0002704)3.93842537
30negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.90312519
31leukocyte aggregation (GO:0070486)3.83524869
32response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.82761458
33response to host immune response (GO:0052572)3.82761458
34positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.81836664
35detection of biotic stimulus (GO:0009595)3.79637897
36regulation of mast cell degranulation (GO:0043304)3.76441805
37immunoglobulin mediated immune response (GO:0016064)3.70289490
38erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.67813769
39L-phenylalanine catabolic process (GO:0006559)3.67813769
40erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.66720623
41L-phenylalanine metabolic process (GO:0006558)3.66720623
42myeloid cell activation involved in immune response (GO:0002275)3.63274383
43microglial cell activation (GO:0001774)3.59305801
44response to host (GO:0075136)3.55070048
45response to host defenses (GO:0052200)3.55070048
46response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.55070048
47negative regulation of T cell mediated immunity (GO:0002710)3.54084112
48defense response to fungus (GO:0050832)3.49244250
49antigen processing and presentation via MHC class Ib (GO:0002475)3.48494665
50regulation of T cell tolerance induction (GO:0002664)3.47856605
51antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.47191009
52antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.47191009
53protoporphyrinogen IX biosynthetic process (GO:0006782)3.46486056
54macrophage activation (GO:0042116)3.45847796
55regulation of mast cell activation involved in immune response (GO:0033006)3.45103436
56fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.44263326
57negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.43675924
58cellular response to type I interferon (GO:0071357)3.42881695
59type I interferon signaling pathway (GO:0060337)3.42881695
60pentose-phosphate shunt (GO:0006098)3.41886285
61negative regulation of phagocytosis (GO:0050765)3.41615960
62response to type I interferon (GO:0034340)3.40785514
63regulation of leukocyte degranulation (GO:0043300)3.36359705
64killing of cells of other organism (GO:0031640)3.33964889
65disruption of cells of other organism (GO:0044364)3.33964889
66germinal center formation (GO:0002467)3.33342290
67leukocyte degranulation (GO:0043299)3.33068566
68regulation of T-helper 2 cell differentiation (GO:0045628)3.30248507
69regulation of isotype switching to IgG isotypes (GO:0048302)3.29749914
70regulation of tolerance induction (GO:0002643)3.27278658
71oxaloacetate metabolic process (GO:0006107)3.27066638
72regulation of T cell mediated cytotoxicity (GO:0001914)3.21469793
73response to muramyl dipeptide (GO:0032495)3.20879895
74positive regulation of T cell mediated cytotoxicity (GO:0001916)3.16861167
75positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.15877284
76regulation of mast cell activation (GO:0033003)3.15422288
77negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.15236148
78negative regulation of T-helper cell differentiation (GO:0045623)3.15236148
79regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.14957086
80regulation of natural killer cell mediated immunity (GO:0002715)3.14957086
81alpha-linolenic acid metabolic process (GO:0036109)3.14055710
82plasma lipoprotein particle assembly (GO:0034377)3.12027800
83negative regulation of type 2 immune response (GO:0002829)3.06362096
84cellular extravasation (GO:0045123)3.04864718
85NADPH regeneration (GO:0006740)3.04611593
86regulation of regulated secretory pathway (GO:1903305)3.03809351
87negative regulation of innate immune response (GO:0045824)3.02748674
88aromatic amino acid family catabolic process (GO:0009074)3.00983621
89neutrophil mediated immunity (GO:0002446)3.00585503
90interferon-gamma-mediated signaling pathway (GO:0060333)3.00426512
91respiratory burst (GO:0045730)2.99905373
92porphyrin-containing compound biosynthetic process (GO:0006779)2.99813616
93heme biosynthetic process (GO:0006783)2.98713433
94valine metabolic process (GO:0006573)2.98575862
95negative regulation of interleukin-6 production (GO:0032715)2.97658769
96tolerance induction (GO:0002507)2.97230881
97kynurenine metabolic process (GO:0070189)2.96159587
98negative regulation of alpha-beta T cell activation (GO:0046636)2.94787368
99regulation of dendritic cell antigen processing and presentation (GO:0002604)2.94005554
100dendritic cell chemotaxis (GO:0002407)2.93669042
101B cell receptor signaling pathway (GO:0050853)2.93103364
102negative regulation of cytokine production involved in immune response (GO:0002719)2.91064787
103erythrocyte maturation (GO:0043249)2.90492907
104positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.90386932
105dendritic cell migration (GO:0036336)2.89925640
106positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.88243639
107very-low-density lipoprotein particle assembly (GO:0034379)2.88169083
108B cell mediated immunity (GO:0019724)2.87379314
109regulation of B cell differentiation (GO:0045577)2.86906667
110regulation of alpha-beta T cell proliferation (GO:0046640)2.85955847
111regulation of regulatory T cell differentiation (GO:0045589)2.85398881
112protein-lipid complex assembly (GO:0065005)2.84693463
113lysine metabolic process (GO:0006553)2.84270935
114lysine catabolic process (GO:0006554)2.84270935
115antigen processing and presentation of endogenous antigen (GO:0019883)2.82990635
116production of molecular mediator involved in inflammatory response (GO:0002532)2.82776645
117urea metabolic process (GO:0019627)2.80626053
118urea cycle (GO:0000050)2.80626053
119response to interleukin-15 (GO:0070672)2.79007035
120positive thymic T cell selection (GO:0045059)2.78018623
121negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.77332749
122imidazole-containing compound metabolic process (GO:0052803)2.75909002
123positive regulation of mast cell activation (GO:0033005)2.75604303
124positive regulation of B cell differentiation (GO:0045579)2.75365723
125tryptophan catabolic process (GO:0006569)2.74796189
126indole-containing compound catabolic process (GO:0042436)2.74796189
127indolalkylamine catabolic process (GO:0046218)2.74796189
128triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.72666830
129Arp2/3 complex-mediated actin nucleation (GO:0034314)2.72188971
1302-oxoglutarate metabolic process (GO:0006103)2.71932274
131glyoxylate metabolic process (GO:0046487)2.71442376
132tetrapyrrole biosynthetic process (GO:0033014)2.70754283
133porphyrin-containing compound metabolic process (GO:0006778)2.67035117
134positive regulation of isotype switching (GO:0045830)2.65370004
135negative regulation of erythrocyte differentiation (GO:0045647)2.64884524
136heme metabolic process (GO:0042168)2.63744140
137neutrophil activation involved in immune response (GO:0002283)2.63191092
138sulfur amino acid catabolic process (GO:0000098)2.62552828
139high-density lipoprotein particle remodeling (GO:0034375)2.59634269
140response to fungus (GO:0009620)2.56620890
141phospholipid efflux (GO:0033700)2.55632911
142defense response to protozoan (GO:0042832)2.54579519
143nitrogen cycle metabolic process (GO:0071941)2.53019519
144barbed-end actin filament capping (GO:0051016)2.50785053
145negative T cell selection (GO:0043383)2.48162368
146positive T cell selection (GO:0043368)2.47520073
147tryptophan metabolic process (GO:0006568)2.47424148
148regulation of interleukin-12 biosynthetic process (GO:0045075)2.43677096
149myeloid leukocyte mediated immunity (GO:0002444)2.42649944
150plasma lipoprotein particle organization (GO:0071827)2.42618432
151neutrophil activation (GO:0042119)2.42376224
152phospholipid homeostasis (GO:0055091)2.41539555
153negative regulation of fibrinolysis (GO:0051918)2.41432822
154leukotriene biosynthetic process (GO:0019370)2.40333443
155ethanol oxidation (GO:0006069)2.40224075
156tricarboxylic acid metabolic process (GO:0072350)2.38455365
157oxygen transport (GO:0015671)2.38310569
158aldehyde catabolic process (GO:0046185)2.37366538
159negative thymic T cell selection (GO:0045060)2.35230287
160bile acid biosynthetic process (GO:0006699)2.34929768
161regulation of myeloid leukocyte mediated immunity (GO:0002886)2.34360322
162cellular response to interleukin-15 (GO:0071350)2.34030648
163positive regulation of DNA recombination (GO:0045911)2.33647513
164negative regulation of protein oligomerization (GO:0032460)2.33474730
165glucose catabolic process (GO:0006007)2.32629204
166amino-acid betaine metabolic process (GO:0006577)2.32033019
167regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.31969483
168protein-lipid complex subunit organization (GO:0071825)2.31224906
169NADP metabolic process (GO:0006739)2.31057973
170mast cell activation (GO:0045576)2.30187057

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.04766270
2MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.89044133
3MYC_22102868_ChIP-Seq_BL_Human2.78140753
4RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.73908032
5PPARA_22158963_ChIP-Seq_LIVER_Mouse2.61479310
6VDR_21846776_ChIP-Seq_THP-1_Human2.61045202
7* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.55735806
8SCL_19346495_ChIP-Seq_HPC-7_Human2.55019681
9RXR_22158963_ChIP-Seq_LIVER_Mouse2.51023032
10STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.42550319
11GATA1_22025678_ChIP-Seq_K562_Human2.31287138
12IRF8_21731497_ChIP-ChIP_J774_Mouse2.23827145
13FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.23153106
14GATA1_19941827_ChIP-Seq_MEL_Mouse2.20455908
15STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.12185970
16IRF8_22096565_ChIP-ChIP_GC-B_Human2.11681284
17NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.11665319
18CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.08916450
19VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.08124262
20MYB_21317192_ChIP-Seq_ERMYB_Mouse2.03530036
21FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.02619536
22E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.00517691
23CIITA_25753668_ChIP-Seq_RAJI_Human1.99849477
24SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.97487525
25IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.95172867
26FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.94810451
27THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.93997834
28MAF_26560356_Chip-Seq_TH1_Human1.88035488
29SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.87330887
30PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.84441366
31BRD4_27068464_Chip-Seq_AML-cells_Mouse1.83855376
32TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.82951980
33SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.82287183
34CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.79716576
35RUNX1_22412390_ChIP-Seq_EML_Mouse1.79439529
36UTX_26944678_Chip-Seq_JUKART_Human1.78313295
37* TCF7_22412390_ChIP-Seq_EML_Mouse1.77238209
38NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.77073105
39* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.76651904
40EGR1_23403033_ChIP-Seq_LIVER_Mouse1.74037669
41* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.73265886
42LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.71994069
43LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.71945558
44* LXR_22292898_ChIP-Seq_THP-1_Human1.66556200
45FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.64612287
46NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.64478701
47SPI1_23547873_ChIP-Seq_NB4_Human1.63199299
48SPI1_23127762_ChIP-Seq_K562_Human1.60055185
49RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.59131826
50MYB_26560356_Chip-Seq_TH1_Human1.59067672
51* LXR_22158963_ChIP-Seq_LIVER_Mouse1.58810962
52GATA1_22383799_ChIP-Seq_G1ME_Mouse1.58290428
53ELF1_17652178_ChIP-ChIP_JURKAT_Human1.57159678
54BP1_19119308_ChIP-ChIP_Hs578T_Human1.55594810
55STAT4_19710469_ChIP-ChIP_TH1__Mouse1.55445693
56STAT6_21828071_ChIP-Seq_BEAS2B_Human1.55388687
57RUNX_20019798_ChIP-Seq_JUKART_Human1.55158758
58GATA3_27048872_Chip-Seq_THYMUS_Human1.51992676
59VDR_24763502_ChIP-Seq_THP-1_Human1.50974846
60Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.50714467
61E2F7_22180533_ChIP-Seq_HELA_Human1.47444137
62IKZF1_21737484_ChIP-ChIP_HCT116_Human1.47145497
63TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.45420378
64SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.45376479
65ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.43493023
66VDR_24787735_ChIP-Seq_THP-1_Human1.42330468
67MAF_26560356_Chip-Seq_TH2_Human1.42101379
68GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.41952870
69MYB_26560356_Chip-Seq_TH2_Human1.41743768
70KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.41249026
71KDM2B_26808549_Chip-Seq_JURKAT_Human1.40194868
72GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.37887051
73KDM2B_26808549_Chip-Seq_DND41_Human1.37853568
74BCL6_27268052_Chip-Seq_Bcells_Human1.37320488
75KDM2B_26808549_Chip-Seq_SUP-B15_Human1.35742808
76IRF8_27001747_Chip-Seq_BMDM_Mouse1.35666016
77GATA1_19941826_ChIP-Seq_K562_Human1.35633001
78GATA2_22383799_ChIP-Seq_G1ME_Mouse1.35377843
79* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.35100272
80BCOR_27268052_Chip-Seq_Bcells_Human1.34063243
81MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.33583515
82SMAD_19615063_ChIP-ChIP_OVARY_Human1.32629573
83KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.30194591
84SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.29357322
85P68_20966046_ChIP-Seq_HELA_Human1.26904824
86PU.1_20513432_ChIP-Seq_Bcells_Mouse1.25793452
87ELF1_20517297_ChIP-Seq_JURKAT_Human1.24542333
88GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.24078433
89NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.22813975
90CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.20964330
91* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.20697695
92EGR1_19374776_ChIP-ChIP_THP-1_Human1.19734423
93SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.16911899
94ELK3_25401928_ChIP-Seq_HUVEC_Human1.16794116
95PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.16218274
96GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.15987694
97CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.14517503
98GATA2_21666600_ChIP-Seq_HMVEC_Human1.13080532
99IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.12272341
100PU_27001747_Chip-Seq_BMDM_Mouse1.12211294
101PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11549429
102SA1_27219007_Chip-Seq_ERYTHROID_Human1.09110183
103VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.08723014
104RACK7_27058665_Chip-Seq_MCF-7_Human1.08386719
105EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.08362093
106ERG_20887958_ChIP-Seq_HPC-7_Mouse1.07749794
107TET1_21451524_ChIP-Seq_MESCs_Mouse1.07420276
108PHF8_20622854_ChIP-Seq_HELA_Human1.06905140
109GATA2_19941826_ChIP-Seq_K562_Human1.06775601
110SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.06659270
111SPI1_20517297_ChIP-Seq_HL60_Human1.06000188
112SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.05497057
113GATA3_26560356_Chip-Seq_TH2_Human1.04093306
114KDM2B_26808549_Chip-Seq_K562_Human1.03853924
115NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.01891568
116E2F1_20622854_ChIP-Seq_HELA_Human1.00993070
117RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.99956307
118* CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.98237354
119DNAJC2_21179169_ChIP-ChIP_NT2_Human0.98096662
120CTCF_27219007_Chip-Seq_ERYTHROID_Human0.97993030
121CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97949140
122NCOR1_26117541_ChIP-Seq_K562_Human0.97700796
123TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.97302638
124SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.96997426
125* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96232203
126FOXP3_21729870_ChIP-Seq_TREG_Human0.96051778
127CTCF_21964334_ChIP-Seq_BJAB-B_Human0.96004141
128RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94250229
129STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.89546718
130CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.89362984
131SMC4_20622854_ChIP-Seq_HELA_Human0.86597048

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003656_abnormal_erythrocyte_physiolo4.04026134
2MP0002139_abnormal_hepatobiliary_system2.93086299
3MP0005360_urolithiasis2.92694761
4MP0003436_decreased_susceptibility_to2.69216441
5MP0005365_abnormal_bile_salt2.63811779
6MP0005671_abnormal_response_to2.50380058
7MP0003806_abnormal_nucleotide_metabolis2.47932823
8MP0009840_abnormal_foam_cell2.37321341
9MP0002837_dystrophic_cardiac_calcinosis2.29925118
10MP0009785_altered_susceptibility_to2.28362070
11MP0005085_abnormal_gallbladder_physiolo2.28048242
12MP0003191_abnormal_cellular_cholesterol2.17640567
13MP0001835_abnormal_antigen_presentation2.02866420
14MP0010329_abnormal_lipoprotein_level2.02638117
15MP0009278_abnormal_bone_marrow2.00415402
16MP0002419_abnormal_innate_immunity1.98108119
17MP0005464_abnormal_platelet_physiology1.92985624
18MP0008875_abnormal_xenobiotic_pharmacok1.92701741
19MP0005397_hematopoietic_system_phenotyp1.89692723
20MP0001545_abnormal_hematopoietic_system1.89692723
21MP0001800_abnormal_humoral_immune1.88950519
22MP0003763_abnormal_thymus_physiology1.88929557
23MP0003303_peritoneal_inflammation1.86488089
24MP0005025_abnormal_response_to1.85309432
25MP0000685_abnormal_immune_system1.83702355
26MP0002398_abnormal_bone_marrow1.81967294
27MP0005083_abnormal_biliary_tract1.76127862
28MP0002396_abnormal_hematopoietic_system1.75948719
29MP0003172_abnormal_lysosome_physiology1.75487904
30MP0003828_pulmonary_edema1.73258251
31MP0002420_abnormal_adaptive_immunity1.69765889
32MP0005000_abnormal_immune_tolerance1.69745140
33MP0001819_abnormal_immune_cell1.67787325
34MP0002405_respiratory_system_inflammati1.66529847
35MP0001790_abnormal_immune_system1.66492142
36MP0005387_immune_system_phenotype1.66492142
37MP0000689_abnormal_spleen_morphology1.65986557
38MP0002723_abnormal_immune_serum1.64797704
39MP0001764_abnormal_homeostasis1.63627869
40MP0006082_CNS_inflammation1.62186885
41MP0000609_abnormal_liver_physiology1.59765938
42MP0000716_abnormal_immune_system1.57232306
43MP0004147_increased_porphyrin_level1.55553645
44MP0001873_stomach_inflammation1.55227691
45MP0002722_abnormal_immune_system1.53956643
46MP0002452_abnormal_antigen_presenting1.53815247
47MP0005451_abnormal_body_composition1.53127638
48MP0004381_abnormal_hair_follicle1.52094900
49MP0002735_abnormal_chemical_nociception1.50829058
50MP0002277_abnormal_respiratory_mucosa1.50109514
51MP0005166_decreased_susceptibility_to1.47025988
52MP0002429_abnormal_blood_cell1.44588181
53MP0001845_abnormal_inflammatory_respons1.44304537
54MP0003724_increased_susceptibility_to1.41690448
55MP0006036_abnormal_mitochondrial_physio1.40798620
56MP0001851_eye_inflammation1.38743749
57MP0005058_abnormal_lysosome_morphology1.37611917
58MP0009333_abnormal_splenocyte_physiolog1.37494121
59MP0008469_abnormal_protein_level1.36969653
60MP0009764_decreased_sensitivity_to1.34315296
61MP0005174_abnormal_tail_pigmentation1.34309819
62MP0001853_heart_inflammation1.34061150
63MP0002132_abnormal_respiratory_system1.31970197
64MP0003075_altered_response_to1.30714907
65MP0005319_abnormal_enzyme/_coenzyme1.28866216
66MP0004883_abnormal_blood_vessel1.28728107
67MP0000858_altered_metastatic_potential1.27857274
68MP0005310_abnormal_salivary_gland1.26418507
69MP0002998_abnormal_bone_remodeling1.24719048
70MP0000703_abnormal_thymus_morphology1.22313500
71MP0002148_abnormal_hypersensitivity_rea1.21955354
72MP0003690_abnormal_glial_cell1.18769418
73MP0002822_catalepsy1.17224869
74MP0004947_skin_inflammation1.17207341
75MP0002118_abnormal_lipid_homeostasis1.16853703
76MP0010155_abnormal_intestine_physiology1.16211362
77MP0005584_abnormal_enzyme/coenzyme_acti1.14918528
78MP0008260_abnormal_autophagy1.09453834
79MP0004808_abnormal_hematopoietic_stem1.09073545
80MP0005332_abnormal_amino_acid1.07724651
81MP0004130_abnormal_muscle_cell1.07253136
82MP0002166_altered_tumor_susceptibility1.05806309
83MP0005164_abnormal_response_to1.04489919
84MP0003183_abnormal_peptide_metabolism1.02939698
85MP0001533_abnormal_skeleton_physiology1.02566865
86MP0000343_altered_response_to1.01230010
87MP0009765_abnormal_xenobiotic_induced1.01104883
88MP0003252_abnormal_bile_duct0.98035674
89MP0003866_abnormal_defecation0.97700966
90MP0008004_abnormal_stomach_pH0.97648394
91MP0000598_abnormal_liver_morphology0.96272792
92MP0003186_abnormal_redox_activity0.96256213
93MP0000465_gastrointestinal_hemorrhage0.95735738
94MP0005390_skeleton_phenotype0.95343959
95MP0005075_abnormal_melanosome_morpholog0.93832092
96MP0008874_decreased_physiological_sensi0.92448735
97MP0001986_abnormal_taste_sensitivity0.92210357
98MP0001666_abnormal_nutrient_absorption0.91723610
99MP0000604_amyloidosis0.91532025
100MP0004510_myositis0.91122364
101MP0001663_abnormal_digestive_system0.89722050
102MP0005167_abnormal_blood-brain_barrier0.89461496
103MP0002138_abnormal_hepatobiliary_system0.87131316
104MP0009643_abnormal_urine_homeostasis0.86295254
105MP0009763_increased_sensitivity_to0.85145305
106MP0003045_fibrosis0.84629892
107MP0005636_abnormal_mineral_homeostasis0.82949418
108MP0003448_altered_tumor_morphology0.82574475
109MP0000490_abnormal_crypts_of0.81820016
110MP0000015_abnormal_ear_pigmentation0.81680135
111MP0002019_abnormal_tumor_incidence0.80802198
112MP0005377_hearing/vestibular/ear_phenot0.79434497
113MP0003878_abnormal_ear_physiology0.79434497
114MP0009642_abnormal_blood_homeostasis0.76343019
115MP0004858_abnormal_nervous_system0.75895730
116MP0003300_gastrointestinal_ulcer0.73288384
117MP0003329_amyloid_beta_deposits0.72575513
118MP0002933_joint_inflammation0.70204932
119MP0003638_abnormal_response/metabolism_0.68141392
120MP0008569_lethality_at_weaning0.68123654
121MP0003795_abnormal_bone_structure0.66962060
122MP0000249_abnormal_blood_vessel0.66197464
123MP0001958_emphysema0.65319042
124MP0002133_abnormal_respiratory_system0.58055280
125MP0005388_respiratory_system_phenotype0.58055280
126MP0003705_abnormal_hypodermis_morpholog0.57209591
127MP0000920_abnormal_myelination0.56972415
128MP0002332_abnormal_exercise_endurance0.53420119
129MP0005535_abnormal_body_temperature0.52088937

Predicted human phenotypes

RankGene SetZ-score
1Orchitis (HP:0100796)5.49824352
2Retrobulbar optic neuritis (HP:0100654)5.03111603
3Optic neuritis (HP:0100653)5.03111603
4Eczematoid dermatitis (HP:0000976)4.34558340
5Recurrent gram-negative bacterial infections (HP:0005420)3.96703790
6Increased IgE level (HP:0003212)3.86460122
7Recurrent abscess formation (HP:0002722)3.82999500
8Keratoconjunctivitis sicca (HP:0001097)3.70371410
9Encephalitis (HP:0002383)3.70033752
10Recurrent bacterial skin infections (HP:0005406)3.45437043
11Keratoconjunctivitis (HP:0001096)3.42771487
12Abnormality of aromatic amino acid family metabolism (HP:0004338)3.42609603
13Vasculitis (HP:0002633)3.37874462
14Hyperlipoproteinemia (HP:0010980)3.26160498
15Chest pain (HP:0100749)3.23620135
16Episodic fever (HP:0001954)3.20951702
17Poikilocytosis (HP:0004447)3.12344488
18Hyperbilirubinemia (HP:0002904)3.11201339
19T lymphocytopenia (HP:0005403)3.00347984
20Abnormality of the heme biosynthetic pathway (HP:0010472)2.98098520
21Deep venous thrombosis (HP:0002625)2.96993080
22Recurrent fungal infections (HP:0002841)2.92191381
23Abnormality of T cell number (HP:0011839)2.91624975
24Hemoptysis (HP:0002105)2.88751188
25Peritonitis (HP:0002586)2.83241333
26Pulmonary infiltrates (HP:0002113)2.82885084
27Spontaneous hematomas (HP:0007420)2.79575103
28Reticulocytosis (HP:0001923)2.76842088
29Hypoplasia of the thymus (HP:0000778)2.74343671
30Cholelithiasis (HP:0001081)2.71425320
31Xanthomatosis (HP:0000991)2.68263448
32Anorexia (HP:0002039)2.64371397
33Amyloidosis (HP:0011034)2.64030536
34Abnormality of monocarboxylic acid metabolism (HP:0010996)2.62326572
35Abnormal gallbladder morphology (HP:0012437)2.61788194
36Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.59505164
37Arterial thrombosis (HP:0004420)2.59332339
38Joint hemorrhage (HP:0005261)2.59299198
39Urticaria (HP:0001025)2.58570583
40Panhypogammaglobulinemia (HP:0003139)2.57651831
41Abnormality of fatty-acid metabolism (HP:0004359)2.55281934
42Increased IgM level (HP:0003496)2.54408180
43Purpura (HP:0000979)2.54043080
44Hypobetalipoproteinemia (HP:0003563)2.52666507
45Ketosis (HP:0001946)2.52254871
46Epistaxis (HP:0000421)2.51136632
47Recurrent skin infections (HP:0001581)2.49882066
48Hypochromic microcytic anemia (HP:0004840)2.48218043
49Osteomyelitis (HP:0002754)2.47775084
50Mediastinal lymphadenopathy (HP:0100721)2.47406409
51Microcytic anemia (HP:0001935)2.46081435
52Increased cerebral lipofuscin (HP:0011813)2.46002714
53Petechiae (HP:0000967)2.45130170
54Abnormality of macrophages (HP:0004311)2.44113168
55Gingivitis (HP:0000230)2.43329511
56Abnormal gallbladder physiology (HP:0012438)2.39953936
57Cholecystitis (HP:0001082)2.39953936
58Joint swelling (HP:0001386)2.37550754
59Sepsis (HP:0100806)2.36103326
60Increased neuronal autofluorescent lipopigment (HP:0002074)2.35921334
61Polygenic inheritance (HP:0010982)2.35214884
62Gingival bleeding (HP:0000225)2.34435717
63Lymphopenia (HP:0001888)2.33790043
64Obstructive lung disease (HP:0006536)2.32403741
65Chronic obstructive pulmonary disease (HP:0006510)2.32403741
66Abnormal platelet volume (HP:0011876)2.30830412
67Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.29044950
68Prolonged bleeding time (HP:0003010)2.28949374
69Hepatosplenomegaly (HP:0001433)2.28350058
70Hypochromic anemia (HP:0001931)2.27268728
71Autoimmune thrombocytopenia (HP:0001973)2.25425916
72Combined immunodeficiency (HP:0005387)2.24560684
73Abnormality of the pleura (HP:0002103)2.24321995
74Hypergammaglobulinemia (HP:0010702)2.22970267
75Recurrent viral infections (HP:0004429)2.22935275
76Hyperammonemia (HP:0001987)2.22858616
77Meningitis (HP:0001287)2.20551926
78Colitis (HP:0002583)2.19322629
79Prolonged partial thromboplastin time (HP:0003645)2.19066494
80Hypercholesterolemia (HP:0003124)2.18580149
81Slow saccadic eye movements (HP:0000514)2.16860841
82Severe combined immunodeficiency (HP:0004430)2.16216050
83Abnormality of cells of the lymphoid lineage (HP:0012140)2.15321933
84Thyroiditis (HP:0100646)2.15294970
85Limb hypertonia (HP:0002509)2.15276578
86Intrahepatic cholestasis (HP:0001406)2.14447976
87Gangrene (HP:0100758)2.13816747
88Stomatitis (HP:0010280)2.13298538
89Elevated erythrocyte sedimentation rate (HP:0003565)2.12660176
90Abnormality of the peritoneum (HP:0002585)2.12313699
91Myositis (HP:0100614)2.11894144
92Complement deficiency (HP:0004431)2.10602327
93Cerebral palsy (HP:0100021)2.09893431
94Acne (HP:0001061)2.07998017
95Abnormality of T cell physiology (HP:0011840)2.06992654
96Abnormality of the endocardium (HP:0004306)2.05618170
97Glomerulopathy (HP:0100820)2.05536308
98Systemic lupus erythematosus (HP:0002725)2.05315468
99Premature loss of primary teeth (HP:0006323)2.04144066
100Abnormality of T cells (HP:0002843)2.03321496
101Gastrointestinal infarctions (HP:0005244)2.02765979
102Vacuolated lymphocytes (HP:0001922)2.02330782
103Cellulitis (HP:0100658)2.02242292
104Leukocytosis (HP:0001974)2.01239182
105Papilledema (HP:0001085)2.01148794
106Skin ulcer (HP:0200042)2.00829647
107Abnormality of iron homeostasis (HP:0011031)1.99299869
108Loss of speech (HP:0002371)1.98730976
109Vertigo (HP:0002321)1.98541429
110Abnormality of the pericardium (HP:0001697)1.97585196
111Growth hormone excess (HP:0000845)1.97111814
112Pulmonary embolism (HP:0002204)1.95860611
113Pustule (HP:0200039)1.95859375
114Hyperglycinuria (HP:0003108)1.94415008
115Abnormality of transition element cation homeostasis (HP:0011030)1.93675615
116Abnormality of the nasal mucosa (HP:0000433)1.93119305
117Increased serum ferritin (HP:0003281)1.92837258
118Gastrointestinal inflammation (HP:0004386)1.92667179
119Abnormality of the gallbladder (HP:0005264)1.92306370
120Acanthocytosis (HP:0001927)1.92174986
121IgM deficiency (HP:0002850)1.92119009
122Keratitis (HP:0000491)1.92019271
123Polycythemia (HP:0001901)1.91590873
124Conjugated hyperbilirubinemia (HP:0002908)1.91467580
125Periodontitis (HP:0000704)1.90662056
126Upper motor neuron abnormality (HP:0002127)1.89520879
127Metaphyseal cupping (HP:0003021)1.89397444
128Agammaglobulinemia (HP:0004432)1.89300555
129Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.88971285
130Abnormal platelet function (HP:0011869)1.88493575
131Impaired platelet aggregation (HP:0003540)1.88493575
132Gastrointestinal stroma tumor (HP:0100723)1.87656443
133Eosinophilia (HP:0001880)1.86548144
134Difficulty running (HP:0009046)1.86333327
135Acute hepatic failure (HP:0006554)1.85346499
136Segmental peripheral demyelination/remyelination (HP:0003481)1.84202639
137Recurrent cutaneous fungal infections (HP:0011370)1.83515984
138Chronic mucocutaneous candidiasis (HP:0002728)1.83515984
139Abnormality of pyrimidine metabolism (HP:0004353)1.83141036
140Inflammation of the large intestine (HP:0002037)1.82332990
141Chronic otitis media (HP:0000389)1.82323789
142Hypermelanotic macule (HP:0001034)1.81137843
143Abnormality of sulfur amino acid metabolism (HP:0004339)1.80522949
144Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.80276952
145Late onset (HP:0003584)1.80056464
146Abnormality of the common coagulation pathway (HP:0010990)1.79946488
147Granulocytopenia (HP:0001913)1.79778240
148Nasal polyposis (HP:0100582)1.79565228
149Recurrent pneumonia (HP:0006532)1.78652184
150Abnormal delayed hypersensitivity skin test (HP:0002963)1.77707759
151Verrucae (HP:0200043)1.77627566
152Toxemia of pregnancy (HP:0100603)1.76463124

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN13.48074210
2MAP4K13.38516055
3GRK62.65664293
4MAP3K122.41341567
5BTK2.34622479
6PRPF4B2.30541355
7TAOK32.19416188
8TYK22.11845902
9TRIB32.09969064
10PKN22.05102252
11TAOK12.03599586
12EEF2K2.01607670
13DAPK22.00715812
14BCKDK1.99869730
15ZAP701.96017413
16MAP2K31.95513600
17MAP3K31.93751263
18KIT1.84571496
19CSK1.79207177
20MAP3K131.77551964
21MAP3K101.74136790
22ITK1.69438007
23SIK21.67868129
24DAPK11.67630123
25TEC1.62129601
26TXK1.61698694
27FGFR41.60677973
28IRAK41.60204907
29SYK1.59798540
30FGR1.56911721
31TNK21.52843692
32EPHB11.48592835
33JAK31.45979937
34FLT31.35165686
35RIPK41.33507458
36TBK11.33442563
37IKBKE1.28722180
38MARK21.26046514
39MATK1.25540002
40SGK31.23226948
41JAK21.20559370
42PRKD21.18516150
43MAPKAPK31.16954800
44MAPK111.16469313
45MAP3K111.13517871
46KSR21.09479524
47HCK1.08892471
48JAK11.07917752
49MAP3K91.06661027
50TAOK21.03773143
51CDK191.01837110
52CSF1R1.01452895
53TGFBR20.98302086
54PAK40.97023341
55SMG10.96081498
56FES0.95746351
57PRKCH0.94878493
58CAMKK20.94837784
59MAP2K60.91879633
60BLK0.91472560
61LCK0.89601271
62PIM10.88328174
63MAP3K10.87175482
64STK100.87008839
65SGK20.83621129
66SIK10.81605501
67MAP3K70.81464576
68MAP3K60.81420095
69PDK10.80003737
70PTK2B0.77460624
71IRAK20.77387070
72MAP2K40.76217902
73DAPK30.75630761
74STK380.73322962
75IRAK10.73038364
76SGK4940.72564759
77SGK2230.72564759
78DYRK1B0.72372791
79RIPK10.69211758
80KDR0.69195130
81STK40.68425967
82CDC42BPA0.68307997
83TTN0.67403106
84LYN0.67142396
85STK110.66470129
86CAMK40.64499985
87RPS6KA60.64186323
88RPS6KA20.63687954
89BRD40.63632280
90MAP3K140.63152120
91SIK30.61802941
92HIPK20.61255357
93TESK20.60661882
94LRRK20.60650522
95BMPR20.57429649
96MAPK40.57203975
97PDPK10.57114239
98MAPK70.55126640
99MYLK0.54550827
100MAP3K20.53636732
101IKBKB0.53279883
102RPS6KL10.51272348
103RPS6KC10.51272348
104CAMKK10.51058162
105CLK10.50437441
106YES10.50364028
107MAPK120.48988866
108PRKG20.47783986
109EPHA30.46857717
110NEK20.45440321
111BMX0.44047081
112MAP3K50.44011734
113FYN0.43735012
114INSRR0.42688995
115FGFR30.41804165
116PINK10.41348448
117MARK30.38926027
118RAF10.37994642
119RET0.36682021
120TRPM70.36206228
121PRKCQ0.35870662
122CDK40.35573206
123MAPKAPK20.35193558
124PRKCD0.34849579
125PRKCZ0.33757579
126KSR10.33260306
127NLK0.32876792
128PRKD10.32432238
129PTK60.31521550

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.51897970
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.03800822
3Staphylococcus aureus infection_Homo sapiens_hsa051502.74570966
42-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.43611726
5Primary immunodeficiency_Homo sapiens_hsa053402.34879826
6Graft-versus-host disease_Homo sapiens_hsa053322.21656569
7Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.19538418
8Allograft rejection_Homo sapiens_hsa053302.17586682
9Sulfur relay system_Homo sapiens_hsa041222.10931243
10Arginine biosynthesis_Homo sapiens_hsa002202.09206932
11Caffeine metabolism_Homo sapiens_hsa002322.04673541
12Autoimmune thyroid disease_Homo sapiens_hsa053202.03261263
13Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.92113700
14Fatty acid degradation_Homo sapiens_hsa000711.91629523
15Malaria_Homo sapiens_hsa051441.89481479
16Pentose phosphate pathway_Homo sapiens_hsa000301.87196932
17Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.84708635
18Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.80160922
19ABC transporters_Homo sapiens_hsa020101.76002702
20Leishmaniasis_Homo sapiens_hsa051401.73463180
21Complement and coagulation cascades_Homo sapiens_hsa046101.73431179
22Peroxisome_Homo sapiens_hsa041461.70344923
23Histidine metabolism_Homo sapiens_hsa003401.65111902
24NOD-like receptor signaling pathway_Homo sapiens_hsa046211.63571645
25Tryptophan metabolism_Homo sapiens_hsa003801.62777138
26Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.60714516
27Biosynthesis of amino acids_Homo sapiens_hsa012301.60634489
28Type I diabetes mellitus_Homo sapiens_hsa049401.58154326
29Carbon metabolism_Homo sapiens_hsa012001.56275644
30Nitrogen metabolism_Homo sapiens_hsa009101.52286197
31Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.51112902
32Antigen processing and presentation_Homo sapiens_hsa046121.47138030
33Viral myocarditis_Homo sapiens_hsa054161.45351337
34Pyruvate metabolism_Homo sapiens_hsa006201.43015508
35Cyanoamino acid metabolism_Homo sapiens_hsa004601.40485759
36Selenocompound metabolism_Homo sapiens_hsa004501.38724872
37Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.36765206
38Phagosome_Homo sapiens_hsa041451.35636906
39Leukocyte transendothelial migration_Homo sapiens_hsa046701.34902053
40beta-Alanine metabolism_Homo sapiens_hsa004101.34437550
41Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.33670116
42African trypanosomiasis_Homo sapiens_hsa051431.32861046
43Propanoate metabolism_Homo sapiens_hsa006401.30665001
44Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.28643209
45Drug metabolism - other enzymes_Homo sapiens_hsa009831.27893419
46Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.26617645
47Platelet activation_Homo sapiens_hsa046111.26542905
48Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.26504046
49Other glycan degradation_Homo sapiens_hsa005111.23418134
50Osteoclast differentiation_Homo sapiens_hsa043801.22471173
51Cysteine and methionine metabolism_Homo sapiens_hsa002701.22074737
52TNF signaling pathway_Homo sapiens_hsa046681.21150607
53B cell receptor signaling pathway_Homo sapiens_hsa046621.20929366
54Pentose and glucuronate interconversions_Homo sapiens_hsa000401.16885994
55Acute myeloid leukemia_Homo sapiens_hsa052211.16344508
56Vitamin B6 metabolism_Homo sapiens_hsa007501.11749213
57VEGF signaling pathway_Homo sapiens_hsa043701.11566105
58Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.05303778
59Hepatitis C_Homo sapiens_hsa051601.04891746
60Starch and sucrose metabolism_Homo sapiens_hsa005001.03491895
61Insulin resistance_Homo sapiens_hsa049311.03433300
62Hepatitis B_Homo sapiens_hsa051611.03128068
63Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.01652466
64Endocytosis_Homo sapiens_hsa041441.00600430
65Glycerolipid metabolism_Homo sapiens_hsa005611.00175109
66Pancreatic cancer_Homo sapiens_hsa052120.99982841
67Fructose and mannose metabolism_Homo sapiens_hsa000510.99338161
68Chronic myeloid leukemia_Homo sapiens_hsa052200.98870466
69Intestinal immune network for IgA production_Homo sapiens_hsa046720.98857030
70T cell receptor signaling pathway_Homo sapiens_hsa046600.98699052
71Regulation of autophagy_Homo sapiens_hsa041400.98031232
72Salmonella infection_Homo sapiens_hsa051320.96100684
73Pertussis_Homo sapiens_hsa051330.95665063
74Folate biosynthesis_Homo sapiens_hsa007900.93516480
75PPAR signaling pathway_Homo sapiens_hsa033200.92659348
76Hematopoietic cell lineage_Homo sapiens_hsa046400.92136385
77Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.91634237
78Measles_Homo sapiens_hsa051620.91489577
79Phospholipase D signaling pathway_Homo sapiens_hsa040720.89790945
80Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.88258125
81Fatty acid metabolism_Homo sapiens_hsa012120.86973222
82Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.83714234
83Renal cell carcinoma_Homo sapiens_hsa052110.83190610
84Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.82320222
85Notch signaling pathway_Homo sapiens_hsa043300.82233141
86Asthma_Homo sapiens_hsa053100.80117129
87Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.79840832
88Rheumatoid arthritis_Homo sapiens_hsa053230.79408551
89Phosphatidylinositol signaling system_Homo sapiens_hsa040700.77850199
90Lysosome_Homo sapiens_hsa041420.77734989
91SNARE interactions in vesicular transport_Homo sapiens_hsa041300.77527975
92Prolactin signaling pathway_Homo sapiens_hsa049170.77479158
93Sphingolipid signaling pathway_Homo sapiens_hsa040710.77003793
94Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.76418292
95Phenylalanine metabolism_Homo sapiens_hsa003600.76292678
96Synaptic vesicle cycle_Homo sapiens_hsa047210.75381940
97Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.75372613
98Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.74931875
99Carbohydrate digestion and absorption_Homo sapiens_hsa049730.74653216
100GnRH signaling pathway_Homo sapiens_hsa049120.73811003
101AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.73318537
102Bile secretion_Homo sapiens_hsa049760.73093042
103Choline metabolism in cancer_Homo sapiens_hsa052310.72776899
104Fat digestion and absorption_Homo sapiens_hsa049750.71971689
105Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.70756581
106Endometrial cancer_Homo sapiens_hsa052130.69014326
107Non-small cell lung cancer_Homo sapiens_hsa052230.68683356
108Tuberculosis_Homo sapiens_hsa051520.68460663
109Galactose metabolism_Homo sapiens_hsa000520.68247303
110RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.67550118
111FoxO signaling pathway_Homo sapiens_hsa040680.66799966
112Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.66036295
113Chemokine signaling pathway_Homo sapiens_hsa040620.65425358
114Adipocytokine signaling pathway_Homo sapiens_hsa049200.65312160
115Amoebiasis_Homo sapiens_hsa051460.63094901
116Jak-STAT signaling pathway_Homo sapiens_hsa046300.62703053
117Chemical carcinogenesis_Homo sapiens_hsa052040.61583686
118Inositol phosphate metabolism_Homo sapiens_hsa005620.60942937
119Insulin signaling pathway_Homo sapiens_hsa049100.59539177
120Rap1 signaling pathway_Homo sapiens_hsa040150.58770371
121Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.58270213
122Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.57924715
123Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.57521541
124Viral carcinogenesis_Homo sapiens_hsa052030.56833490
125Epstein-Barr virus infection_Homo sapiens_hsa051690.56136762
126NF-kappa B signaling pathway_Homo sapiens_hsa040640.55990466
127MAPK signaling pathway_Homo sapiens_hsa040100.55825972
128mTOR signaling pathway_Homo sapiens_hsa041500.54835690
129Herpes simplex infection_Homo sapiens_hsa051680.54827574
130Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.53910344
131Long-term potentiation_Homo sapiens_hsa047200.53849673
132Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.53318752
133Colorectal cancer_Homo sapiens_hsa052100.52787266
134Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.52783465
135Collecting duct acid secretion_Homo sapiens_hsa049660.52408781
136Influenza A_Homo sapiens_hsa051640.51926682
137HTLV-I infection_Homo sapiens_hsa051660.50558653
138Butanoate metabolism_Homo sapiens_hsa006500.49167889
139HIF-1 signaling pathway_Homo sapiens_hsa040660.48841400
140Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.48772148
141Neurotrophin signaling pathway_Homo sapiens_hsa047220.48274144
142Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.47421681
143ErbB signaling pathway_Homo sapiens_hsa040120.47400689
144Lysine degradation_Homo sapiens_hsa003100.46207499
145Glycerophospholipid metabolism_Homo sapiens_hsa005640.46205722
146Dorso-ventral axis formation_Homo sapiens_hsa043200.44996725
147Toll-like receptor signaling pathway_Homo sapiens_hsa046200.44368272
148Estrogen signaling pathway_Homo sapiens_hsa049150.42923707
149Toxoplasmosis_Homo sapiens_hsa051450.41786241
150Legionellosis_Homo sapiens_hsa051340.41574620
151Maturity onset diabetes of the young_Homo sapiens_hsa049500.40653378
152Retinol metabolism_Homo sapiens_hsa008300.40100946
153DNA replication_Homo sapiens_hsa030300.39071804
154Shigellosis_Homo sapiens_hsa051310.38954645
155Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.38612882
156Type II diabetes mellitus_Homo sapiens_hsa049300.37805269
157Glycosaminoglycan degradation_Homo sapiens_hsa005310.36406465
158Apoptosis_Homo sapiens_hsa042100.35575488
159Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.34935958

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