ABTB2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of vitamin D biosynthetic process (GO:0060556)6.73825486
2regulation of vitamin metabolic process (GO:0030656)5.50691853
3proline biosynthetic process (GO:0006561)5.45709561
4regulation of chronic inflammatory response (GO:0002676)5.34337324
5regulation of cytokine secretion involved in immune response (GO:0002739)4.83881009
6positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.80963446
7branching involved in labyrinthine layer morphogenesis (GO:0060670)4.79393225
8regulation of fever generation (GO:0031620)4.78035393
9positive regulation of heat generation (GO:0031652)4.77449511
10regulation of integrin activation (GO:0033623)4.71183719
11regulation of membrane protein ectodomain proteolysis (GO:0051043)4.54034458
12embryonic process involved in female pregnancy (GO:0060136)4.48719109
13positive regulation of chemokine biosynthetic process (GO:0045080)4.34798980
14regulation of interferon-alpha production (GO:0032647)4.23187445
15positive regulation of protein homooligomerization (GO:0032464)4.22648296
16proline metabolic process (GO:0006560)4.22219693
17regulation of podosome assembly (GO:0071801)4.16447783
18activation of MAPKKK activity (GO:0000185)4.12431530
19positive regulation of heterotypic cell-cell adhesion (GO:0034116)4.05029884
20type I interferon signaling pathway (GO:0060337)4.03936213
21cellular response to type I interferon (GO:0071357)4.03936213
22regulation of chemokine biosynthetic process (GO:0045073)3.98329772
23response to type I interferon (GO:0034340)3.97396454
24lipopolysaccharide-mediated signaling pathway (GO:0031663)3.85916702
25negative T cell selection (GO:0043383)3.84221370
26response to peptidoglycan (GO:0032494)3.81207261
27transcription from mitochondrial promoter (GO:0006390)3.79387668
28protein localization to endosome (GO:0036010)3.78714997
29activated T cell proliferation (GO:0050798)3.78255736
30regulation of heterotypic cell-cell adhesion (GO:0034114)3.71526453
31negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.65438548
32regulation of NFAT protein import into nucleus (GO:0051532)3.60997328
33negative thymic T cell selection (GO:0045060)3.57920244
34positive regulation of nitric oxide biosynthetic process (GO:0045429)3.54123528
35positive thymic T cell selection (GO:0045059)3.51920635
36negative regulation of fatty acid biosynthetic process (GO:0045717)3.51753666
37regulation of type I interferon-mediated signaling pathway (GO:0060338)3.51296247
38regulation of interleukin-12 biosynthetic process (GO:0045075)3.51139269
39creatine metabolic process (GO:0006600)3.50035014
40negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.50000276
41regulation of protein homooligomerization (GO:0032462)3.49400253
42regulation of heat generation (GO:0031650)3.47397924
43regulation of nitric oxide biosynthetic process (GO:0045428)3.47355225
44adhesion of symbiont to host (GO:0044406)3.45707538
45regulation of immunoglobulin secretion (GO:0051023)3.43777843
46cellular response to interferon-alpha (GO:0035457)3.42522605
47regulation of gamma-delta T cell differentiation (GO:0045586)3.41368119
48virion attachment to host cell (GO:0019062)3.40608914
49adhesion of symbiont to host cell (GO:0044650)3.40608914
50positive regulation of gamma-delta T cell activation (GO:0046645)3.36929477
51embryonic placenta development (GO:0001892)3.33484902
52T-helper 1 type immune response (GO:0042088)3.30183422
53thymic T cell selection (GO:0045061)3.26024489
54positive regulation of interferon-alpha production (GO:0032727)3.23990614
55positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.23918294
56negative regulation of amino acid transport (GO:0051956)3.22415630
57apoptotic process involved in morphogenesis (GO:0060561)3.20268540
58germinal center formation (GO:0002467)3.19906662
59regulation of interleukin-2 biosynthetic process (GO:0045076)3.18281701
60positive regulation of NF-kappaB import into nucleus (GO:0042346)3.17717476
61low-density lipoprotein particle clearance (GO:0034383)3.17362643
62positive regulation of interleukin-2 production (GO:0032743)3.16552190
63positive regulation of Cdc42 GTPase activity (GO:0043089)3.15594268
64hypotonic response (GO:0006971)3.14967569
65positive regulation of acute inflammatory response (GO:0002675)3.13767599
66negative regulation of protein oligomerization (GO:0032460)3.13671365
67negative regulation of cytokine production involved in immune response (GO:0002719)3.12290351
68regulation of gamma-delta T cell activation (GO:0046643)3.12122830
69cellular response to lipopolysaccharide (GO:0071222)3.07724197
70T cell selection (GO:0045058)3.07241865
71positive regulation of interleukin-4 production (GO:0032753)3.04925657
72regulation of interferon-gamma biosynthetic process (GO:0045072)3.03934160
73positive T cell selection (GO:0043368)3.03393372
74regulation of interleukin-8 biosynthetic process (GO:0045414)3.02179596
75T cell migration (GO:0072678)3.01888022
76membrane tubulation (GO:0097320)3.00599336
77negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.00421341
78cellular response to zinc ion (GO:0071294)3.00305530
79negative regulation of nitric oxide biosynthetic process (GO:0045019)2.99581313
80regulation of cholesterol homeostasis (GO:2000188)2.98268875
81negative regulation of potassium ion transmembrane transport (GO:1901380)2.96998563
82regulation of cholesterol storage (GO:0010885)2.93485893
83positive regulation of transcription factor import into nucleus (GO:0042993)2.93175619
84positive regulation of natural killer cell differentiation (GO:0032825)2.93103857
85cellular response to molecule of bacterial origin (GO:0071219)2.91157880
86regulation of mononuclear cell migration (GO:0071675)2.89957330
87T cell costimulation (GO:0031295)2.89357888
88positive regulation of p38MAPK cascade (GO:1900745)2.89057639
89establishment of apical/basal cell polarity (GO:0035089)2.88280163
90macrophage activation involved in immune response (GO:0002281)2.88094961
91growth hormone receptor signaling pathway (GO:0060396)2.87623517
92signal complex assembly (GO:0007172)2.85151584
93positive regulation of humoral immune response (GO:0002922)2.84881468
94positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.83741155
95response to protozoan (GO:0001562)2.82896931
96negative regulation of lipid storage (GO:0010888)2.82790917
97regulation of T-helper 1 cell differentiation (GO:0045625)2.82385595
98lymphocyte costimulation (GO:0031294)2.81826368
99face development (GO:0060324)2.81531397
100cellular response to nicotine (GO:0071316)2.81496945
101regulation of NF-kappaB import into nucleus (GO:0042345)2.81494320
102sarcoplasmic reticulum calcium ion transport (GO:0070296)2.80296700
103positive regulation of lipid storage (GO:0010884)2.76848245
104oxidative demethylation (GO:0070989)2.76227132
105glycosphingolipid catabolic process (GO:0046479)2.75056144
106regulation of interleukin-12 production (GO:0032655)2.74853060
107regulation of isotype switching to IgG isotypes (GO:0048302)2.74465321
108defense response to protozoan (GO:0042832)2.73511744
109mitotic G1/S transition checkpoint (GO:0044819)2.72818357
110negative regulation of viral genome replication (GO:0045071)2.71994427
111response to muramyl dipeptide (GO:0032495)2.71808101
112positive regulation of T-helper cell differentiation (GO:0045624)2.71092523
113glutamine family amino acid biosynthetic process (GO:0009084)2.70499660
114modulation by symbiont of host cellular process (GO:0044068)2.70378213
115regulation of RIG-I signaling pathway (GO:0039535)2.70155105
116regulation of T-helper cell differentiation (GO:0045622)2.69919988
117negative regulation of growth of symbiont in host (GO:0044130)2.69791315
118negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.69791315
119modulation of growth of symbiont involved in interaction with host (GO:0044144)2.69791315
120regulation of growth of symbiont in host (GO:0044126)2.69791315
121regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.69638053
122negative regulation of JAK-STAT cascade (GO:0046426)2.69355598
123membrane raft organization (GO:0031579)2.68977025
124positive regulation of steroid biosynthetic process (GO:0010893)2.68963266
125regulation of type 2 immune response (GO:0002828)2.68710848
126antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.62880052
127antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.62880052
128NIK/NF-kappaB signaling (GO:0038061)2.62547118
129negative regulation of myeloid cell apoptotic process (GO:0033033)2.61010909
130positive regulation of interleukin-6 production (GO:0032755)2.60882307
131regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.60565998
132myeloid dendritic cell differentiation (GO:0043011)2.59577857
133mitotic G1 DNA damage checkpoint (GO:0031571)2.58829407
134dendritic cell differentiation (GO:0097028)2.58334847
135cell adhesion mediated by integrin (GO:0033627)2.58210037
136positive regulation of protein oligomerization (GO:0032461)2.57759710
137decidualization (GO:0046697)2.57297710
138regulation of protein oligomerization (GO:0032459)2.57088028
139regulation of dendritic cell antigen processing and presentation (GO:0002604)2.57050323
140regulation of interferon-beta biosynthetic process (GO:0045357)2.56649322
141cellular response to ATP (GO:0071318)2.56596783
142regulation of inflammatory response to antigenic stimulus (GO:0002861)2.55051584
143negative regulation of viral release from host cell (GO:1902187)2.54955568
144regulation of interleukin-4 production (GO:0032673)2.54262178
145regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.54063870
146response to manganese ion (GO:0010042)2.53693016
147ventricular trabecula myocardium morphogenesis (GO:0003222)2.53107313
148positive regulation by host of viral transcription (GO:0043923)2.52695554
149cellular response to biotic stimulus (GO:0071216)2.52136808
150positive regulation of lymphocyte apoptotic process (GO:0070230)2.50950400
151interferon-gamma-mediated signaling pathway (GO:0060333)2.50804819
152positive regulation of interferon-beta production (GO:0032728)2.50231758
153acetyl-CoA metabolic process (GO:0006084)2.50195979
154negative regulation of Ras GTPase activity (GO:0034261)2.48374005
155labyrinthine layer development (GO:0060711)2.47240291
156regulation of alpha-beta T cell proliferation (GO:0046640)2.46344746
157very-low-density lipoprotein particle assembly (GO:0034379)2.45745105
158regulation of T cell tolerance induction (GO:0002664)2.45058869
159positive regulation of alpha-beta T cell proliferation (GO:0046641)2.44791057
160anatomical structure regression (GO:0060033)2.44187903
161positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.42145870
162positive regulation of astrocyte differentiation (GO:0048711)2.40679779
163G1 DNA damage checkpoint (GO:0044783)2.40481414
164antigen processing and presentation of endogenous antigen (GO:0019883)2.39913998
165leukocyte aggregation (GO:0070486)2.39906620
166JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.39466210
167cellular response to growth hormone stimulus (GO:0071378)2.38683471
168oxygen transport (GO:0015671)2.38372479
169regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.37978710
170alkaloid metabolic process (GO:0009820)2.37056072
171response to laminar fluid shear stress (GO:0034616)2.36545180
172retinoic acid receptor signaling pathway (GO:0048384)2.36372596
173positive regulation of interleukin-17 production (GO:0032740)2.35811745
174sulfur amino acid catabolic process (GO:0000098)2.35152302
175establishment or maintenance of monopolar cell polarity (GO:0061339)2.34006021
176establishment of monopolar cell polarity (GO:0061162)2.34006021
177regulation of T-helper 2 cell differentiation (GO:0045628)2.33610648
178positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.33441864
179positive regulation of type 2 immune response (GO:0002830)2.31472609
180regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.31068280
181negative regulation of interleukin-12 production (GO:0032695)2.30376886
182response to interleukin-15 (GO:0070672)2.29809663
183positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.29809626
184fatty-acyl-CoA biosynthetic process (GO:0046949)2.29767343
185positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.29411208
186cellular response to virus (GO:0098586)2.28879278

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.39158356
2TP63_17297297_ChIP-ChIP_HaCaT_Human3.29093947
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.94881111
4EGR1_19374776_ChIP-ChIP_THP-1_Human2.94319649
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.90857332
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.87510108
7STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.74139504
8CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.63803987
9IRF8_21731497_ChIP-ChIP_J774_Mouse2.39447514
10THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.27505298
11* RXR_22158963_ChIP-Seq_LIVER_Mouse2.26309909
12BP1_19119308_ChIP-ChIP_Hs578T_Human2.25062448
13* KDM2B_26808549_Chip-Seq_DND41_Human2.22046141
14* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.21555315
15VDR_21846776_ChIP-Seq_THP-1_Human2.14486782
16ESR1_21235772_ChIP-Seq_MCF-7_Human2.12794238
17RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.09021756
18PPARA_22158963_ChIP-Seq_LIVER_Mouse2.06960787
19* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.06372216
20LXR_22292898_ChIP-Seq_THP-1_Human2.05252381
21* KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.01978734
22ZNF263_19887448_ChIP-Seq_K562_Human2.01662287
23* LXR_22158963_ChIP-Seq_LIVER_Mouse1.98646728
24ESR2_21235772_ChIP-Seq_MCF-7_Human1.98454671
25ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.97987435
26IRF8_27001747_Chip-Seq_BMDM_Mouse1.97538076
27TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.86737790
28IRF8_22096565_ChIP-ChIP_GC-B_Human1.86681029
29NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.84928643
30* RACK7_27058665_Chip-Seq_MCF-7_Human1.81686782
31* MAF_26560356_Chip-Seq_TH1_Human1.79518530
32* FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.77189108
33* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.76937575
34ELK3_25401928_ChIP-Seq_HUVEC_Human1.72269987
35SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.71280912
36* RUNX_20019798_ChIP-Seq_JUKART_Human1.70717452
37Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.69535524
38STAT6_21828071_ChIP-Seq_BEAS2B_Human1.68733517
39IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.67596258
40MYB_21317192_ChIP-Seq_ERMYB_Mouse1.60656132
41* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.55244167
42P300_27058665_Chip-Seq_ZR-75-30cells_Human1.50938981
43STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.50614136
44* KDM2B_26808549_Chip-Seq_JURKAT_Human1.49810200
45TCF7_22412390_ChIP-Seq_EML_Mouse1.48461540
46EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.47200722
47* KDM2B_26808549_Chip-Seq_K562_Human1.46331794
48KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.45521988
49KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.45521988
50KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.45521988
51SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.44969824
52MYC_22102868_ChIP-Seq_BL_Human1.44204223
53TRIM28_21343339_ChIP-Seq_HEK293_Human1.41588524
54* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.38211366
55NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.36870681
56IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.34627324
57HIF1A_21447827_ChIP-Seq_MCF-7_Human1.34514716
58* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.31792650
59FOXO3_23340844_ChIP-Seq_DLD1_Human1.30342645
60* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.29137458
61FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.27936372
62* UTX_26944678_Chip-Seq_JUKART_Human1.25860235
63E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.24012794
64* MAF_26560356_Chip-Seq_TH2_Human1.23217328
65VDR_24763502_ChIP-Seq_THP-1_Human1.23029300
66ERG_21242973_ChIP-ChIP_JURKAT_Human1.22903870
67* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.22627236
68POU5F1_16518401_ChIP-PET_MESCs_Mouse1.20789725
69* VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.20396520
70ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.19793568
71* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.19489604
72* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.18099841
73NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.17940918
74TBX20_22328084_ChIP-Seq_HEART_Mouse1.17491045
75TBX20_22080862_ChIP-Seq_HEART_Mouse1.17491045
76* UBF1/2_26484160_Chip-Seq_HMECs_Human1.17220504
77* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.16843496
78RARG_19884340_ChIP-ChIP_MEFs_Mouse1.14781293
79SMAD_19615063_ChIP-ChIP_OVARY_Human1.14266510
80P63_26484246_Chip-Seq_KERATINOCYTES_Human1.13842032
81* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.13662038
82PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.13601349
83CLOCK_20551151_ChIP-Seq_293T_Human1.13036201
84TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.12949466
85ZFP281_27345836_Chip-Seq_ESCs_Mouse1.12911701
86ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.11456531
87GATA1_19941827_ChIP-Seq_MEL_Mouse1.10565059
88MYB_26560356_Chip-Seq_TH2_Human1.08981592
89* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.08069902
90RUNX1_27514584_Chip-Seq_MCF-7_Human1.07208460
91TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.06457567
92SRY_22984422_ChIP-ChIP_TESTIS_Rat1.06044626
93VDR_24787735_ChIP-Seq_THP-1_Human1.05832297
94PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.05675864
95TP53_22127205_ChIP-Seq_IMR90_Human1.04956157
96KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.04951365
97* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.04684729
98STAT3_1855785_ChIP-Seq_MESCs_Mouse1.02892194
99* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.02557410
100MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.02497327
101MYB_26560356_Chip-Seq_TH1_Human1.02082177
102NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.01948748
103TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.01699083
104* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.01663448
105* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01613822
106SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.01047861
107SMC4_20622854_ChIP-Seq_HELA_Human1.01028941
108* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.00584152
109EGR1_19032775_ChIP-ChIP_M12_Human1.00553167
110NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.99202875
111BCOR_27268052_Chip-Seq_Bcells_Human0.99181728
112* CTCF_21964334_ChIP-Seq_BJAB-B_Human0.99095728
113TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.98921538
114* SA1_27219007_Chip-Seq_ERYTHROID_Human0.98873064
115NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.98395339
116ATF3_27146783_Chip-Seq_COLON_Human0.96274316
117SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.95859207
118WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.95808699
119SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.95552353
120SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.95552353
121SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95203701
122SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.94818422
123STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.94756631
124GATA2_21666600_ChIP-Seq_HMVEC_Human0.94521480
125SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.94475581
126MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.94242341
127ESR1_20079471_ChIP-ChIP_T-47D_Human0.94084762
128* PPAR_26484153_Chip-Seq_NCI-H1993_Human0.93890797
129SOX9_24532713_ChIP-Seq_HFSC_Mouse0.91556257
130UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.90924129
131NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.89194065
132BRD4_27068464_Chip-Seq_AML-cells_Mouse0.88572750
133SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.87301165
134NFIB_24661679_ChIP-Seq_LUNG_Mouse0.86001143
135* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.84512381

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system3.85696398
2MP0009278_abnormal_bone_marrow3.85608465
3MP0000685_abnormal_immune_system3.41082180
4MP0005058_abnormal_lysosome_morphology3.33266766
5MP0004510_myositis2.96533222
6MP0003763_abnormal_thymus_physiology2.72696490
7MP0002332_abnormal_exercise_endurance2.69257921
8MP0005171_absent_coat_pigmentation2.67099895
9MP0003453_abnormal_keratinocyte_physiol2.65718093
10MP0003724_increased_susceptibility_to2.52905509
11MP0006082_CNS_inflammation2.19877785
12MP0008057_abnormal_DNA_replication2.11536785
13MP0008004_abnormal_stomach_pH2.04971453
14MP0002009_preneoplasia2.00608647
15MP0003075_altered_response_to1.99520203
16MP0004233_abnormal_muscle_weight1.97560677
17MP0002254_reproductive_system_inflammat1.90879582
18MP0009764_decreased_sensitivity_to1.86565872
19MP0003436_decreased_susceptibility_to1.83141310
20MP0003045_fibrosis1.78419461
21MP0002166_altered_tumor_susceptibility1.71819142
22MP0002933_joint_inflammation1.69989817
23MP0002405_respiratory_system_inflammati1.68331610
24MP0004947_skin_inflammation1.67345359
25MP0001533_abnormal_skeleton_physiology1.66247813
26MP0005076_abnormal_cell_differentiation1.66221051
27MP0001348_abnormal_lacrimal_gland1.62701212
28MP0009840_abnormal_foam_cell1.62443197
29MP0005387_immune_system_phenotype1.61496135
30MP0001790_abnormal_immune_system1.61496135
31MP0002796_impaired_skin_barrier1.61069228
32MP0004185_abnormal_adipocyte_glucose1.60527624
33MP0005257_abnormal_intraocular_pressure1.57851494
34MP0002419_abnormal_innate_immunity1.57688576
35MP0000920_abnormal_myelination1.57153991
36MP0005451_abnormal_body_composition1.54641089
37MP0003646_muscle_fatigue1.52309704
38MP0005085_abnormal_gallbladder_physiolo1.51255797
39MP0009333_abnormal_splenocyte_physiolog1.50643881
40MP0004084_abnormal_cardiac_muscle1.49718578
41MP0004381_abnormal_hair_follicle1.48223559
42MP0000343_altered_response_to1.47411625
43MP0005671_abnormal_response_to1.46755700
44MP0001800_abnormal_humoral_immune1.42909699
45MP0003705_abnormal_hypodermis_morpholog1.42413075
46MP0010630_abnormal_cardiac_muscle1.42129872
47MP0005330_cardiomyopathy1.41825443
48MP0004134_abnormal_chest_morphology1.41545872
49MP0008775_abnormal_heart_ventricle1.39632760
50MP0005000_abnormal_immune_tolerance1.38428066
51MP0002006_tumorigenesis1.38237763
52MP0005167_abnormal_blood-brain_barrier1.38109420
53MP0003091_abnormal_cell_migration1.37639553
54MP0000751_myopathy1.37150834
55MP0000579_abnormal_nail_morphology1.37065854
56MP0010155_abnormal_intestine_physiology1.35587289
57MP0003566_abnormal_cell_adhesion1.34875153
58MP0004087_abnormal_muscle_fiber1.34572523
59MP0003300_gastrointestinal_ulcer1.34500682
60MP0003191_abnormal_cellular_cholesterol1.33920499
61MP0003195_calcinosis1.32916414
62MP0005365_abnormal_bile_salt1.32414738
63MP0008469_abnormal_protein_level1.32310347
64MP0005666_abnormal_adipose_tissue1.31025890
65MP0002269_muscular_atrophy1.29835342
66MP0002282_abnormal_trachea_morphology1.28547809
67MP0005623_abnormal_meninges_morphology1.28058892
68MP0001545_abnormal_hematopoietic_system1.27820028
69MP0005397_hematopoietic_system_phenotyp1.27820028
70MP0002877_abnormal_melanocyte_morpholog1.25268527
71MP0003828_pulmonary_edema1.24712477
72MP0003172_abnormal_lysosome_physiology1.22738094
73MP0000858_altered_metastatic_potential1.21966100
74MP0010030_abnormal_orbit_morphology1.21832373
75MP0001873_stomach_inflammation1.19479338
76MP0001835_abnormal_antigen_presentation1.19137126
77MP0002998_abnormal_bone_remodeling1.16534807
78MP0002723_abnormal_immune_serum1.16490836
79MP0001853_heart_inflammation1.15883493
80MP0001340_abnormal_eyelid_morphology1.15519549
81MP0005166_decreased_susceptibility_to1.15428576
82MP0003690_abnormal_glial_cell1.12614543
83MP0008995_early_reproductive_senescence1.12312693
84MP0004858_abnormal_nervous_system1.11853210
85MP0010352_gastrointestinal_tract_polyps1.11604159
86MP0003329_amyloid_beta_deposits1.10679512
87MP0003303_peritoneal_inflammation1.09437296
88MP0005025_abnormal_response_to1.08346204
89MP0005023_abnormal_wound_healing1.08108338
90MP0005083_abnormal_biliary_tract1.06315043
91MP0003137_abnormal_impulse_conducting1.04940162
92MP0002148_abnormal_hypersensitivity_rea1.04636777
93MP0009785_altered_susceptibility_to1.03068349
94MP0004130_abnormal_muscle_cell1.01024218
95MP0010234_abnormal_vibrissa_follicle1.00642204
96MP0002452_abnormal_antigen_presenting0.99599709
97MP0005375_adipose_tissue_phenotype0.98245120
98MP0003879_abnormal_hair_cell0.97923934
99MP0000733_abnormal_muscle_development0.96946214
100MP0002398_abnormal_bone_marrow0.95657536
101MP0002420_abnormal_adaptive_immunity0.94846878
102MP0005360_urolithiasis0.93810802
103MP0000750_abnormal_muscle_regeneration0.93759815
104MP0000703_abnormal_thymus_morphology0.93685151
105MP0001819_abnormal_immune_cell0.93250827
106MP0005165_increased_susceptibility_to0.92742972
107MP0002060_abnormal_skin_morphology0.92185369
108MP0002106_abnormal_muscle_physiology0.91131552
109MP0006054_spinal_hemorrhage0.90874325
110MP0005310_abnormal_salivary_gland0.90754573
111MP0000609_abnormal_liver_physiology0.90641667
112MP0005501_abnormal_skin_physiology0.90567970
113MP0001849_ear_inflammation0.89016028
114MP0000716_abnormal_immune_system0.88244710
115MP0003950_abnormal_plasma_membrane0.87150303
116MP0000689_abnormal_spleen_morphology0.86337787
117MP0008260_abnormal_autophagy0.85147125
118MP0003806_abnormal_nucleotide_metabolis0.84704589
119MP0000371_diluted_coat_color0.84479256
120MP0002089_abnormal_postnatal_growth/wei0.84346997
121MP0008874_decreased_physiological_sensi0.82448127
122MP0003634_abnormal_glial_cell0.79862044
123MP0003866_abnormal_defecation0.79798156
124MP0004036_abnormal_muscle_relaxation0.78910806
125MP0005390_skeleton_phenotype0.78859811
126MP0005647_abnormal_sex_gland0.78593968
127MP0001845_abnormal_inflammatory_respons0.78115311
128MP0003183_abnormal_peptide_metabolism0.77992213
129MP0005164_abnormal_response_to0.77919254
130MP0005248_abnormal_Harderian_gland0.76148405
131MP0002971_abnormal_brown_adipose0.76032306
132MP0002722_abnormal_immune_system0.75363455
133MP0000604_amyloidosis0.74608399
134MP0010307_abnormal_tumor_latency0.74246410
135MP0003448_altered_tumor_morphology0.74016236
136MP0002138_abnormal_hepatobiliary_system0.72690594
137MP0000470_abnormal_stomach_morphology0.72374525
138MP0005266_abnormal_metabolism0.72266351
139MP0000762_abnormal_tongue_morphology0.71928837
140MP0009763_increased_sensitivity_to0.71541651
141MP0003221_abnormal_cardiomyocyte_apopto0.70694602
142MP0003656_abnormal_erythrocyte_physiolo0.70221343
143MP0000747_muscle_weakness0.70180113
144MP0009115_abnormal_fat_cell0.69656257
145MP0001346_abnormal_lacrimal_gland0.68456368
146MP0001216_abnormal_epidermal_layer0.66697771
147MP0005197_abnormal_uvea_morphology0.64664246
148MP0001542_abnormal_bone_strength0.64137175
149MP0009765_abnormal_xenobiotic_induced0.63483463
150MP0005319_abnormal_enzyme/_coenzyme0.62675048
151MP0004808_abnormal_hematopoietic_stem0.62451131

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glycolipid metabolism (HP:0010969)5.37166095
2Abnormality of liposaccharide metabolism (HP:0010968)5.37166095
3Abnormality of glycosphingolipid metabolism (HP:0004343)5.37166095
4Increased IgM level (HP:0003496)4.72177599
5Nuclear cataract (HP:0100018)4.34788515
6Pustule (HP:0200039)4.30404506
7Loss of speech (HP:0002371)4.26752369
8Orchitis (HP:0100796)4.19033323
9Optic neuritis (HP:0100653)4.11548743
10Retrobulbar optic neuritis (HP:0100654)4.11548743
11Systemic lupus erythematosus (HP:0002725)4.08716877
12Dysostosis multiplex (HP:0000943)3.72006838
13Neurofibrillary tangles (HP:0002185)3.64751217
14Premature skin wrinkling (HP:0100678)3.56063355
15Hyporeflexia of lower limbs (HP:0002600)3.52757533
16Alopecia of scalp (HP:0002293)3.50244006
17Ulnar bowing (HP:0003031)3.32726501
18Thin bony cortex (HP:0002753)3.27395025
19Vacuolated lymphocytes (HP:0001922)3.22666347
20T lymphocytopenia (HP:0005403)3.21837779
21Turricephaly (HP:0000262)3.21623679
22Apathy (HP:0000741)3.19871665
23Abnormality of T cell number (HP:0011839)3.15614417
24Myositis (HP:0100614)3.10299366
25Increased cerebral lipofuscin (HP:0011813)3.07242529
26Disinhibition (HP:0000734)3.05732026
27Abnormality of mucopolysaccharide metabolism (HP:0011020)3.05208952
28Abnormality of polysaccharide metabolism (HP:0011012)3.05208952
29Abnormality of glycosaminoglycan metabolism (HP:0004371)3.05208952
30Myocardial infarction (HP:0001658)3.03822849
31Mucopolysacchariduria (HP:0008155)3.00058908
32Urinary glycosaminoglycan excretion (HP:0003541)3.00058908
33Annular pancreas (HP:0001734)2.99039894
34Exercise-induced myalgia (HP:0003738)2.96760513
35Interstitial pulmonary disease (HP:0006530)2.96291624
36Cerebral inclusion bodies (HP:0100314)2.93048976
37Male infertility (HP:0003251)2.91291889
38Hypoplastic ischia (HP:0003175)2.91264782
39Diminished motivation (HP:0000745)2.90703805
40Abnormality of macrophages (HP:0004311)2.89847232
41Axonal loss (HP:0003447)2.88137761
42Abnormal hemoglobin (HP:0011902)2.86851356
43Coronal craniosynostosis (HP:0004440)2.86017356
44Rib fusion (HP:0000902)2.81990494
45Diaphragmatic weakness (HP:0009113)2.79806464
46Concave nail (HP:0001598)2.77302431
47Abnormality of monocarboxylic acid metabolism (HP:0010996)2.68935557
48Asymmetric septal hypertrophy (HP:0001670)2.66541827
49Glomerulonephritis (HP:0000099)2.66448465
50Stomatitis (HP:0010280)2.66255752
51Abnormality of the ischium (HP:0003174)2.65348074
52Mutism (HP:0002300)2.63792642
53Keratoconjunctivitis sicca (HP:0001097)2.59513997
54Hyperparathyroidism (HP:0000843)2.58752126
55Complement deficiency (HP:0004431)2.51234373
56Poikiloderma (HP:0001029)2.49758623
57Autoimmune thrombocytopenia (HP:0001973)2.49450882
58Abnormality of the aortic arch (HP:0012303)2.48295665
59Neuronal loss in central nervous system (HP:0002529)2.46681845
60Prolonged neonatal jaundice (HP:0006579)2.45385588
61Recurrent fungal infections (HP:0002841)2.44305712
62Increased serum ferritin (HP:0003281)2.43814187
63Muscle fiber splitting (HP:0003555)2.41586371
64Cerebral aneurysm (HP:0004944)2.39486327
65Elevated erythrocyte sedimentation rate (HP:0003565)2.39270702
66Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.39247637
67Intestinal fistula (HP:0100819)2.37888222
68Hypochromic microcytic anemia (HP:0004840)2.37410609
69Vertebral hypoplasia (HP:0008417)2.34330316
70Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.34330316
71Abnormality of male internal genitalia (HP:0000022)2.30577434
72Bilateral sensorineural hearing impairment (HP:0008619)2.30012213
73Deep venous thrombosis (HP:0002625)2.29605608
74Facial hemangioma (HP:0000329)2.28717091
75Metaphyseal irregularity (HP:0003025)2.28119425
76Sudden death (HP:0001699)2.25617012
77Alacrima (HP:0000522)2.22944644
78Hypergammaglobulinemia (HP:0010702)2.22881366
79Keratoconjunctivitis (HP:0001096)2.22084830
80Rectal fistula (HP:0100590)2.21867671
81Rectovaginal fistula (HP:0000143)2.21867671
82Large for gestational age (HP:0001520)2.21435233
83Metaphyseal cupping (HP:0003021)2.21169048
84Gangrene (HP:0100758)2.20818731
85Malnutrition (HP:0004395)2.20794555
86Achilles tendon contracture (HP:0001771)2.20340853
87Peripheral hypomyelination (HP:0007182)2.18743525
88Polycythemia (HP:0001901)2.18742835
89Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.18670382
90Albinism (HP:0001022)2.17527078
91Congenital hip dislocation (HP:0001374)2.16726473
92Ventricular tachycardia (HP:0004756)2.16377832
93Abnormality of complement system (HP:0005339)2.16006936
94Bone pain (HP:0002653)2.15590520
95Hamartoma (HP:0010566)2.14751466
96Increased neuronal autofluorescent lipopigment (HP:0002074)2.14404777
97Hemorrhage of the eye (HP:0011885)2.13564726
98Muscle fibrillation (HP:0010546)2.11993023
99Abnormality of the Achilles tendon (HP:0005109)2.10658850
100Vertebral compression fractures (HP:0002953)2.08414682
101Segmental peripheral demyelination/remyelination (HP:0003481)2.07975187
102Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.07132177
103Depressed nasal tip (HP:0000437)2.06850545
104Amyloidosis (HP:0011034)2.06644920
105Hypotrichosis (HP:0001006)2.05793179
106IgA deficiency (HP:0002720)2.04389740
107Anteriorly placed anus (HP:0001545)2.03865583
108Clumsiness (HP:0002312)1.99745229
109Eczematoid dermatitis (HP:0000976)1.95447776
110Peripheral demyelination (HP:0011096)1.94501839
111Increased IgE level (HP:0003212)1.94477686
112Increased CSF protein (HP:0002922)1.94057499
113Popliteal pterygium (HP:0009756)1.93790736
114Vaginal fistula (HP:0004320)1.92905060
115Mediastinal lymphadenopathy (HP:0100721)1.91249652
116Ulnar claw (HP:0001178)1.90651254
117Distal lower limb muscle weakness (HP:0009053)1.89858128
118Flat acetabular roof (HP:0003180)1.89847479
119Aplasia of the musculature (HP:0100854)1.87891064
120Broad alveolar ridges (HP:0000187)1.87521154
121Arterial thrombosis (HP:0004420)1.87233620
122Bulbar palsy (HP:0001283)1.86738695
123Right ventricular cardiomyopathy (HP:0011663)1.86563920
124Progressive neurologic deterioration (HP:0002344)1.86492746
125Onion bulb formation (HP:0003383)1.86090635
126Tongue fasciculations (HP:0001308)1.85773779
127Nausea (HP:0002018)1.82638420
128Abnormality of T cells (HP:0002843)1.82186898
129Xanthomatosis (HP:0000991)1.81619242
130Abnormality of the nasal septum (HP:0000419)1.80877425
131Pancreatic islet-cell hyperplasia (HP:0004510)1.80018021
132Distal lower limb amyotrophy (HP:0008944)1.79246496
133Elevated alkaline phosphatase (HP:0003155)1.78858345
134Intrahepatic cholestasis (HP:0001406)1.78836851
135Exercise-induced muscle cramps (HP:0003710)1.78682162
136Hypercortisolism (HP:0001578)1.77896939
137Palmoplantar hyperkeratosis (HP:0000972)1.77832363
138Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.76247291
139Difficulty running (HP:0009046)1.76018559
140Pathologic fracture (HP:0002756)1.75454198
141Thoracolumbar scoliosis (HP:0002944)1.75286586
142Bowed forearm bones (HP:0003956)1.75162308
143Bowing of the arm (HP:0006488)1.75162308
144Fused cervical vertebrae (HP:0002949)1.74760373
145Supranuclear gaze palsy (HP:0000605)1.74665840
146Acne (HP:0001061)1.74547488
147Joint stiffness (HP:0001387)1.74523769
148Upper limb amyotrophy (HP:0009129)1.73664516
149Distal upper limb amyotrophy (HP:0007149)1.73664516
150Protuberant abdomen (HP:0001538)1.73230361
151Abnormality of aromatic amino acid family metabolism (HP:0004338)1.72432832
152IgG deficiency (HP:0004315)1.71805327
153Hypobetalipoproteinemia (HP:0003563)1.70964071
154Aseptic necrosis (HP:0010885)1.70303583
155Increased connective tissue (HP:0009025)1.70282038
156Gastrointestinal infarctions (HP:0005244)1.69264494
157Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.69163617
158Split hand (HP:0001171)1.68508495
159Dementia (HP:0000726)1.68390861
160Peritonitis (HP:0002586)1.67844190
161Epiphyseal dysplasia (HP:0002656)1.67001712
162Pulmonary infiltrates (HP:0002113)1.66912553
163Abnormality of the thoracic spine (HP:0100711)1.66335769
164Abnormality of the endocardium (HP:0004306)1.65770826
165Lower limb hyperreflexia (HP:0002395)1.65759413
166Vertebral fusion (HP:0002948)1.65568570
167Bundle branch block (HP:0011710)1.65521532
168Parakeratosis (HP:0001036)1.65217474
169Zonular cataract (HP:0010920)1.65131837
170Colitis (HP:0002583)1.64752300
171Cervical subluxation (HP:0003308)1.64719460
172Severe combined immunodeficiency (HP:0004430)1.64475224
173Rickets (HP:0002748)1.64197897
174Broad face (HP:0000283)1.63515364
175Thoracic kyphosis (HP:0002942)1.63133336
176Esophageal varix (HP:0002040)1.62938993
177Purpura (HP:0000979)1.62927555
178Delayed epiphyseal ossification (HP:0002663)1.62393223
179Hyperacusis (HP:0010780)1.61815986
180Joint swelling (HP:0001386)1.61068897
181Hypoalphalipoproteinemia (HP:0003233)1.61051562
182Decreased lacrimation (HP:0000633)1.60867563
183Hypochromic anemia (HP:0001931)1.60782771
184Polyneuropathy (HP:0001271)1.60642495
185Inflammation of the large intestine (HP:0002037)1.60525014
186J-shaped sella turcica (HP:0002680)1.60296567
187Increased mean platelet volume (HP:0011877)1.59906064

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK35.60504816
2ICK4.75655161
3TYRO33.58131707
4DDR23.24892058
5TAOK23.20191673
6EPHB13.12893960
7NME22.85789032
8CSK2.45910790
9MAP3K112.38369753
10FGFR42.35006208
11MOS2.32509347
12MAPK152.27486422
13GRK72.26677030
14BMX2.18484109
15FGR2.11098744
16MAP4K12.08219676
17MAP3K62.06206367
18TRIB32.00841841
19EPHA31.79733707
20TRPM71.76176419
21PIM21.64534828
22PDGFRA1.57205422
23MAP3K141.54447144
24EPHA21.51061768
25JAK31.46245196
26PINK11.42026388
27TXK1.41917637
28DYRK1B1.40476165
29PRKD21.38016992
30SIK11.35427906
31TTN1.35035778
32TBK11.33617623
33IRAK41.32569283
34MAP3K101.30417919
35ARAF1.28532461
36MAP3K131.25756236
37UHMK11.25752937
38ITK1.25289722
39TYK21.25283258
40PDGFRB1.22954453
41PHKG21.22010937
42PHKG11.22010937
43MAP3K91.18686319
44MAP2K31.18480181
45IKBKB1.16836622
46MATK1.15003910
47PIM11.14743877
48IRAK21.10653873
49DMPK1.08845290
50IKBKE1.08412229
51CHUK1.05825560
52STK391.04854657
53GSK3A1.04279747
54MAP3K11.02941829
55MAP3K51.00171256
56CDK120.98416243
57SMG10.98292864
58PKN20.95783068
59FGFR30.94877861
60JAK10.93762186
61NLK0.92061603
62STK100.90901582
63MST1R0.87420522
64ZAP700.87220921
65CDC42BPA0.86253686
66LCK0.85093472
67TGFBR20.85052649
68CLK10.81692662
69YES10.81492470
70MST40.81216195
71MAPK110.78495071
72PTK60.76252963
73PAK40.75315722
74ABL20.74095722
75JAK20.73560698
76CDK60.73111040
77TESK10.72285879
78PKN10.72069963
79RIPK10.71749639
80MAP3K30.69038945
81HIPK20.67816527
82TESK20.67721814
83PRPF4B0.66815256
84MARK30.66762143
85MTOR0.66093621
86RPS6KA60.65220383
87RPS6KL10.65196713
88RPS6KC10.65196713
89BLK0.63625321
90MAP3K70.62980311
91BMPR20.61953725
92PTK20.61723931
93EGFR0.60368472
94INSR0.59399952
95HCK0.58933350
96EPHB20.58753177
97IRAK10.58301439
98RPS6KA10.57878636
99PRKD10.57015302
100MET0.56787803
101FGFR10.54297988
102DYRK30.54006739
103RPS6KA20.52451129
104LMTK20.51981826
105ROCK20.50551259
106PRKCH0.49974005
107EEF2K0.47410420
108CDK90.46834786
109PRKAA10.46750336
110CAMK1D0.46396675
111SIK30.46330940
112PRKCQ0.46259440
113NEK90.46254610
114MELK0.46241409
115SIK20.45515966
116RET0.45262247
117MAPK40.45240588
118OBSCN0.44476307
119KSR20.44130743
120LATS20.43678027
121WNK40.42554336
122PRKAA20.42400046
123LRRK20.41838039
124BRAF0.41697968
125PAK30.40363318
126MARK20.39844967
127PDPK10.38902889
128WNK10.38645803
129LIMK10.38318150
130TAOK10.38034757
131FGFR20.36486012
132MAP3K80.35746388
133ERN10.35705429
134PAK60.33034343
135STK240.32114125
136MAPK10.31961900
137MAPKAPK20.31332860
138LATS10.31236087
139PRKD30.31013338
140RIPK40.28067792
141MUSK0.27951091
142DAPK30.27131141
143CDK150.26616868

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000613.85330137
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.98889742
3Other glycan degradation_Homo sapiens_hsa005112.67536879
4Viral myocarditis_Homo sapiens_hsa054162.62425853
5Primary immunodeficiency_Homo sapiens_hsa053402.53542043
6African trypanosomiasis_Homo sapiens_hsa051432.27613589
7Steroid biosynthesis_Homo sapiens_hsa001002.18549601
8Pertussis_Homo sapiens_hsa051332.13021150
9Prion diseases_Homo sapiens_hsa050202.02105970
10Glycosaminoglycan degradation_Homo sapiens_hsa005311.98455678
11Allograft rejection_Homo sapiens_hsa053301.93331751
12Graft-versus-host disease_Homo sapiens_hsa053321.93010841
13Influenza A_Homo sapiens_hsa051641.92060177
14Fatty acid metabolism_Homo sapiens_hsa012121.87837781
15Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.80489856
16T cell receptor signaling pathway_Homo sapiens_hsa046601.74313350
17Lysosome_Homo sapiens_hsa041421.73784270
18Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.70548880
19Arginine biosynthesis_Homo sapiens_hsa002201.68504637
20Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.66925732
21Rheumatoid arthritis_Homo sapiens_hsa053231.66002488
22NF-kappa B signaling pathway_Homo sapiens_hsa040641.65515231
23Adherens junction_Homo sapiens_hsa045201.62509366
24Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.59921163
25Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.59911685
26Fatty acid elongation_Homo sapiens_hsa000621.55138041
27Measles_Homo sapiens_hsa051621.54342565
28Notch signaling pathway_Homo sapiens_hsa043301.54327084
29Bladder cancer_Homo sapiens_hsa052191.53562969
30Dorso-ventral axis formation_Homo sapiens_hsa043201.51751346
31Intestinal immune network for IgA production_Homo sapiens_hsa046721.49545990
32Tuberculosis_Homo sapiens_hsa051521.38630655
33Primary bile acid biosynthesis_Homo sapiens_hsa001201.36663968
34Arginine and proline metabolism_Homo sapiens_hsa003301.35880632
35Autoimmune thyroid disease_Homo sapiens_hsa053201.32713502
36Staphylococcus aureus infection_Homo sapiens_hsa051501.29702740
37Lysine degradation_Homo sapiens_hsa003101.23925300
382-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.22215438
39mTOR signaling pathway_Homo sapiens_hsa041501.21237076
40Shigellosis_Homo sapiens_hsa051311.18703036
41Acute myeloid leukemia_Homo sapiens_hsa052211.14721882
42Jak-STAT signaling pathway_Homo sapiens_hsa046301.08407678
43Nitrogen metabolism_Homo sapiens_hsa009101.07123002
44Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.06518537
45Leishmaniasis_Homo sapiens_hsa051401.05192487
46VEGF signaling pathway_Homo sapiens_hsa043701.04689049
47Small cell lung cancer_Homo sapiens_hsa052221.02720256
48Hippo signaling pathway_Homo sapiens_hsa043901.02080890
49Toxoplasmosis_Homo sapiens_hsa051451.01724648
50Fructose and mannose metabolism_Homo sapiens_hsa000510.99899432
51Chronic myeloid leukemia_Homo sapiens_hsa052200.97603023
52TGF-beta signaling pathway_Homo sapiens_hsa043500.96867579
53Adipocytokine signaling pathway_Homo sapiens_hsa049200.96335435
54Osteoclast differentiation_Homo sapiens_hsa043800.95941356
55Hedgehog signaling pathway_Homo sapiens_hsa043400.95606652
56Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.95034160
57Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.92924113
58Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.89746411
59Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.88262407
60Biosynthesis of amino acids_Homo sapiens_hsa012300.86334393
61Regulation of actin cytoskeleton_Homo sapiens_hsa048100.86127915
62Legionellosis_Homo sapiens_hsa051340.86075509
63Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.83698566
64Circadian rhythm_Homo sapiens_hsa047100.83493411
65Fatty acid degradation_Homo sapiens_hsa000710.83252306
66Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.83205987
67Galactose metabolism_Homo sapiens_hsa000520.83021738
68Focal adhesion_Homo sapiens_hsa045100.82657591
69TNF signaling pathway_Homo sapiens_hsa046680.82270825
70Sphingolipid metabolism_Homo sapiens_hsa006000.81191609
71RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.81086811
72Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.80754300
73Chemokine signaling pathway_Homo sapiens_hsa040620.78481353
74Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.77410447
75Toll-like receptor signaling pathway_Homo sapiens_hsa046200.77100446
76Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.75684835
77AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.74777780
78Malaria_Homo sapiens_hsa051440.74547845
79Prolactin signaling pathway_Homo sapiens_hsa049170.74506346
80Proteoglycans in cancer_Homo sapiens_hsa052050.74187219
81Asthma_Homo sapiens_hsa053100.74108449
82MicroRNAs in cancer_Homo sapiens_hsa052060.74097432
83Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.73420468
84Type II diabetes mellitus_Homo sapiens_hsa049300.73169549
85Salmonella infection_Homo sapiens_hsa051320.71649472
86Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.71491100
87Pancreatic cancer_Homo sapiens_hsa052120.70970040
88B cell receptor signaling pathway_Homo sapiens_hsa046620.70860389
89Dilated cardiomyopathy_Homo sapiens_hsa054140.69257498
90Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.68817558
91Basal cell carcinoma_Homo sapiens_hsa052170.68537236
92Complement and coagulation cascades_Homo sapiens_hsa046100.67307706
93Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.66145791
94Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.66036288
95Hepatitis B_Homo sapiens_hsa051610.65642225
96Insulin resistance_Homo sapiens_hsa049310.65568292
97Neurotrophin signaling pathway_Homo sapiens_hsa047220.64567037
98Epstein-Barr virus infection_Homo sapiens_hsa051690.64293060
99Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.64035631
100Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.62326093
101Apoptosis_Homo sapiens_hsa042100.61697993
102Amoebiasis_Homo sapiens_hsa051460.60904986
103Insulin signaling pathway_Homo sapiens_hsa049100.60226920
104Ovarian steroidogenesis_Homo sapiens_hsa049130.59884009
105Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.59677793
106Tight junction_Homo sapiens_hsa045300.59481841
107Histidine metabolism_Homo sapiens_hsa003400.59476632
108Tryptophan metabolism_Homo sapiens_hsa003800.58645074
109PPAR signaling pathway_Homo sapiens_hsa033200.58482581
110Longevity regulating pathway - mammal_Homo sapiens_hsa042110.57775671
111Transcriptional misregulation in cancer_Homo sapiens_hsa052020.57536265
112Leukocyte transendothelial migration_Homo sapiens_hsa046700.57097474
113Herpes simplex infection_Homo sapiens_hsa051680.57065427
114Renal cell carcinoma_Homo sapiens_hsa052110.56585497
115Central carbon metabolism in cancer_Homo sapiens_hsa052300.55054210
116MAPK signaling pathway_Homo sapiens_hsa040100.54725877
117ECM-receptor interaction_Homo sapiens_hsa045120.54433179
118Phenylalanine metabolism_Homo sapiens_hsa003600.53951440
119HIF-1 signaling pathway_Homo sapiens_hsa040660.53692032
120ErbB signaling pathway_Homo sapiens_hsa040120.53598901
121FoxO signaling pathway_Homo sapiens_hsa040680.53215130
122Sphingolipid signaling pathway_Homo sapiens_hsa040710.52077864
123NOD-like receptor signaling pathway_Homo sapiens_hsa046210.51920550
124Hepatitis C_Homo sapiens_hsa051600.50715824
125Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.49791812
126Choline metabolism in cancer_Homo sapiens_hsa052310.49155236
127Endocytosis_Homo sapiens_hsa041440.47391607
128Hematopoietic cell lineage_Homo sapiens_hsa046400.47179124
129Phagosome_Homo sapiens_hsa041450.46185760
130HTLV-I infection_Homo sapiens_hsa051660.42195248
131Vibrio cholerae infection_Homo sapiens_hsa051100.39226586
132Endometrial cancer_Homo sapiens_hsa052130.37411258
133Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.37269552
134Pentose phosphate pathway_Homo sapiens_hsa000300.36985828
135Thyroid hormone signaling pathway_Homo sapiens_hsa049190.36355850
136Viral carcinogenesis_Homo sapiens_hsa052030.35837796
137Folate biosynthesis_Homo sapiens_hsa007900.33604852
138Prostate cancer_Homo sapiens_hsa052150.31990986

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