ACAA2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The encoded protein catalyzes the last step of the mitochondrial fatty acid beta-oxidation spiral. Unlike most mitochondrial matrix proteins, it contains a non-cleavable amino-terminal targeting signal. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.60199642
2L-phenylalanine catabolic process (GO:0006559)6.60199642
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.42129566
4L-phenylalanine metabolic process (GO:0006558)6.42129566
5aromatic amino acid family catabolic process (GO:0009074)5.92867014
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.86482287
7glyoxylate metabolic process (GO:0046487)5.64144293
8kynurenine metabolic process (GO:0070189)5.48280679
9alpha-linolenic acid metabolic process (GO:0036109)5.47825085
10indole-containing compound catabolic process (GO:0042436)5.37236820
11indolalkylamine catabolic process (GO:0046218)5.37236820
12tryptophan catabolic process (GO:0006569)5.37236820
13lysine catabolic process (GO:0006554)5.29218506
14lysine metabolic process (GO:0006553)5.29218506
15bile acid biosynthetic process (GO:0006699)5.29046142
16epoxygenase P450 pathway (GO:0019373)5.26687936
17exogenous drug catabolic process (GO:0042738)5.18794794
18tryptophan metabolic process (GO:0006568)5.07596815
19fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.06926762
20regulation of triglyceride catabolic process (GO:0010896)5.06191372
21urea metabolic process (GO:0019627)5.00017306
22urea cycle (GO:0000050)5.00017306
23uronic acid metabolic process (GO:0006063)4.99429242
24glucuronate metabolic process (GO:0019585)4.99429242
25drug catabolic process (GO:0042737)4.98392264
26sulfur amino acid catabolic process (GO:0000098)4.97358429
27high-density lipoprotein particle remodeling (GO:0034375)4.93466014
28negative regulation of fibrinolysis (GO:0051918)4.89412251
29amino-acid betaine metabolic process (GO:0006577)4.88017516
30cysteine metabolic process (GO:0006534)4.84694680
31peptidyl-glutamic acid carboxylation (GO:0017187)4.71536380
32protein carboxylation (GO:0018214)4.71536380
33complement activation, alternative pathway (GO:0006957)4.70379956
34regulation of protein activation cascade (GO:2000257)4.68534402
35serine family amino acid catabolic process (GO:0009071)4.68239552
36regulation of fibrinolysis (GO:0051917)4.66817375
37cellular ketone body metabolic process (GO:0046950)4.62395246
38nitrogen cycle metabolic process (GO:0071941)4.61686627
39homocysteine metabolic process (GO:0050667)4.50064635
40fatty acid beta-oxidation (GO:0006635)4.49831003
41bile acid metabolic process (GO:0008206)4.48065305
42regulation of complement activation (GO:0030449)4.38658361
43positive regulation of heterotypic cell-cell adhesion (GO:0034116)4.38246286
44reverse cholesterol transport (GO:0043691)4.37634543
45alpha-amino acid catabolic process (GO:1901606)4.37264788
46very-low-density lipoprotein particle assembly (GO:0034379)4.37095767
47regulation of cholesterol esterification (GO:0010872)4.36188295
48acylglycerol homeostasis (GO:0055090)4.35093004
49triglyceride homeostasis (GO:0070328)4.35093004
50plasma lipoprotein particle remodeling (GO:0034369)4.32750287
51protein-lipid complex remodeling (GO:0034368)4.32750287
52macromolecular complex remodeling (GO:0034367)4.32750287
53aromatic amino acid family metabolic process (GO:0009072)4.32327794
54omega-hydroxylase P450 pathway (GO:0097267)4.27301865
55ethanol oxidation (GO:0006069)4.24473944
56fatty acid oxidation (GO:0019395)4.23945382
57acetyl-CoA metabolic process (GO:0006084)4.23726945
58plasma lipoprotein particle clearance (GO:0034381)4.20355394
592-oxoglutarate metabolic process (GO:0006103)4.18068411
60short-chain fatty acid metabolic process (GO:0046459)4.16385877
61lipid oxidation (GO:0034440)4.16083620
62fatty acid catabolic process (GO:0009062)4.14490726
63phospholipid efflux (GO:0033700)4.14289413
64tyrosine metabolic process (GO:0006570)4.11380133
65cellular amino acid catabolic process (GO:0009063)4.08662998
66carnitine metabolic process (GO:0009437)4.07241763
67drug metabolic process (GO:0017144)4.04242096
68glycine metabolic process (GO:0006544)4.03646126
69monocarboxylic acid catabolic process (GO:0072329)4.03242294
70fatty acid transmembrane transport (GO:1902001)4.01798430
71aspartate family amino acid catabolic process (GO:0009068)4.01071119
72negative regulation of cholesterol transport (GO:0032375)3.99320131
73negative regulation of sterol transport (GO:0032372)3.99320131
74ketone body metabolic process (GO:1902224)3.98945393
75positive regulation of fatty acid beta-oxidation (GO:0032000)3.96186969
76coenzyme catabolic process (GO:0009109)3.94743215
77positive regulation of lipid catabolic process (GO:0050996)3.89006958
78carboxylic acid catabolic process (GO:0046395)3.88169327
79organic acid catabolic process (GO:0016054)3.88169327
80protein-lipid complex assembly (GO:0065005)3.81483768
81phospholipid homeostasis (GO:0055091)3.80887208
82serine family amino acid metabolic process (GO:0009069)3.79888607
83valine metabolic process (GO:0006573)3.78215178
84bile acid and bile salt transport (GO:0015721)3.78032412
85cellular glucuronidation (GO:0052695)3.77605803
86benzene-containing compound metabolic process (GO:0042537)3.76448263
87glutamate metabolic process (GO:0006536)3.75282062
88indolalkylamine metabolic process (GO:0006586)3.75141682
89cellular modified amino acid catabolic process (GO:0042219)3.73907702
90carnitine shuttle (GO:0006853)3.72624135
91branched-chain amino acid catabolic process (GO:0009083)3.72380705
92dicarboxylic acid biosynthetic process (GO:0043650)3.71533607
93cholesterol efflux (GO:0033344)3.70356513
94amine catabolic process (GO:0009310)3.66779376
95cellular biogenic amine catabolic process (GO:0042402)3.66779376
96plasma lipoprotein particle assembly (GO:0034377)3.65685194
97imidazole-containing compound metabolic process (GO:0052803)3.65107176
98negative regulation of lipase activity (GO:0060192)3.63010453
99tricarboxylic acid cycle (GO:0006099)3.61866557
100negative regulation of fatty acid biosynthetic process (GO:0045717)3.59588502
101positive regulation of triglyceride lipase activity (GO:0061365)3.59111422
102positive regulation of lipoprotein lipase activity (GO:0051006)3.59111422
103serine family amino acid biosynthetic process (GO:0009070)3.58030989
104arginine metabolic process (GO:0006525)3.57441509
105NADH metabolic process (GO:0006734)3.57105293
106positive regulation of fatty acid oxidation (GO:0046321)3.52554441
107cholesterol homeostasis (GO:0042632)3.52515242
108low-density lipoprotein particle remodeling (GO:0034374)3.52022690
109aldehyde catabolic process (GO:0046185)3.51718823
110regulation of sequestering of triglyceride (GO:0010889)3.50674099
111regulation of cholesterol metabolic process (GO:0090181)3.50614612
112heme transport (GO:0015886)3.49390539
113blood coagulation, intrinsic pathway (GO:0007597)3.49173541
114fibrinolysis (GO:0042730)3.47326931
115phenylpropanoid metabolic process (GO:0009698)3.46362061
116plasma lipoprotein particle organization (GO:0071827)3.45754370
117ethanol metabolic process (GO:0006067)3.45169223
118oxaloacetate metabolic process (GO:0006107)3.40722329
119water-soluble vitamin biosynthetic process (GO:0042364)3.39512457
120vitamin biosynthetic process (GO:0009110)3.33668314
121fat-soluble vitamin biosynthetic process (GO:0042362)3.27824171
122intestinal cholesterol absorption (GO:0030299)3.24669896
123oxidative demethylation (GO:0070989)3.21374929
124protein-lipid complex subunit organization (GO:0071825)3.20814343
125xenobiotic catabolic process (GO:0042178)3.17039127
126S-adenosylmethionine metabolic process (GO:0046500)3.14021605
127intestinal absorption (GO:0050892)3.13665945
128sterol homeostasis (GO:0055092)3.09850190
129acylglycerol catabolic process (GO:0046464)3.08251514
130neutral lipid catabolic process (GO:0046461)3.08251514
131primary alcohol metabolic process (GO:0034308)3.06668869
132polyketide metabolic process (GO:0030638)3.06056333
133doxorubicin metabolic process (GO:0044598)3.06056333
134daunorubicin metabolic process (GO:0044597)3.06056333
135regulation of heterotypic cell-cell adhesion (GO:0034114)3.05528759
136L-ascorbic acid metabolic process (GO:0019852)3.03290607
137branched-chain amino acid metabolic process (GO:0009081)3.03245630
138transcytosis (GO:0045056)3.03084350
139triglyceride catabolic process (GO:0019433)2.99956883

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse7.78346186
2* PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.91400074
3PPARA_22158963_ChIP-Seq_LIVER_Mouse6.87362693
4EGR1_23403033_ChIP-Seq_LIVER_Mouse6.09870770
5LXR_22158963_ChIP-Seq_LIVER_Mouse6.05499292
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.89771573
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.65977477
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.00775237
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.85803422
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.49315089
11* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.18731146
12GABP_17652178_ChIP-ChIP_JURKAT_Human2.79887154
13HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.25719226
14CLOCK_20551151_ChIP-Seq_293T_Human2.10112811
15EST1_17652178_ChIP-ChIP_JURKAT_Human2.09307069
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.08764929
17NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.04698482
18TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.01487528
19* ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.1657597
20JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.99257254
21GATA1_22025678_ChIP-Seq_K562_Human1.94297332
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.84739539
23GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.74572955
24ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.66887320
25ELK1_19687146_ChIP-ChIP_HELA_Human1.56002685
26HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.55232656
27* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.50956323
28RARG_19884340_ChIP-ChIP_MEFs_Mouse1.47946351
29MYC_18555785_ChIP-Seq_MESCs_Mouse1.46775018
30FOXA2_19822575_ChIP-Seq_HepG2_Human1.44908066
31STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.42604996
32ZNF263_19887448_ChIP-Seq_K562_Human1.38338153
33FLI1_27457419_Chip-Seq_LIVER_Mouse1.37923708
34AR_21909140_ChIP-Seq_LNCAP_Human1.37157648
35ETS1_20019798_ChIP-Seq_JURKAT_Human1.36186840
36THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.35987106
37STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.35025008
38* HNF4A_19822575_ChIP-Seq_HepG2_Human1.31269608
39FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.29841400
40TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.28013576
41MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.25513659
42PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.25096589
43* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23897115
44IGF1R_20145208_ChIP-Seq_DFB_Human1.22651016
45PADI4_21655091_ChIP-ChIP_MCF-7_Human1.22510817
46PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.22278294
47PCGF2_27294783_Chip-Seq_ESCs_Mouse1.21065069
48VDR_23849224_ChIP-Seq_CD4+_Human1.20885472
49ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.18396406
50MYC_18358816_ChIP-ChIP_MESCs_Mouse1.18170147
51HTT_18923047_ChIP-ChIP_STHdh_Human1.17414294
52FOXP3_21729870_ChIP-Seq_TREG_Human1.17362838
53EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.15277133
54E2F7_22180533_ChIP-Seq_HELA_Human1.14463195
55PCGF2_27294783_Chip-Seq_NPCs_Mouse1.14461625
56HOXB4_20404135_ChIP-ChIP_EML_Mouse1.14368453
57E2F4_17652178_ChIP-ChIP_JURKAT_Human1.13575035
58ELF1_17652178_ChIP-ChIP_JURKAT_Human1.12594060
59GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.11044775
60SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.10934557
61SOX2_19829295_ChIP-Seq_ESCs_Human1.10187896
62NANOG_19829295_ChIP-Seq_ESCs_Human1.10187896
63POU3F2_20337985_ChIP-ChIP_501MEL_Human1.09084365
64MYC_19030024_ChIP-ChIP_MESCs_Mouse1.09000454
65NFE2_27457419_Chip-Seq_LIVER_Mouse1.07616886
66CDX2_22108803_ChIP-Seq_LS180_Human1.06699631
67ZNF274_21170338_ChIP-Seq_K562_Hela1.06693236
68EZH2_27294783_Chip-Seq_NPCs_Mouse1.06410919
69* RXRA_24833708_ChIP-Seq_LIVER_Mouse1.03463558
70ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.03459697
71FOXA1_27270436_Chip-Seq_PROSTATE_Human1.03342262
72FOXA1_25329375_ChIP-Seq_VCAP_Human1.03342262
73IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.02855045
74POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.02735349
75NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.02271514
76SALL1_21062744_ChIP-ChIP_HESCs_Human1.02195759
77* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.01743059
78* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.01228944
79FOXA1_21572438_ChIP-Seq_LNCaP_Human1.00939760
80TCF3_18692474_ChIP-Seq_MEFs_Mouse1.00690406
81NANOG_16153702_ChIP-ChIP_HESCs_Human1.00326127
82POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.98798607
83NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.98504026
84CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.98357984
85TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97824723
86SUZ12_27294783_Chip-Seq_NPCs_Mouse0.97806643
87RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.97271590
88FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.97174084
89BCAT_22108803_ChIP-Seq_LS180_Human0.93937105
90VDR_22108803_ChIP-Seq_LS180_Human0.93620269
91GATA4_25053715_ChIP-Seq_YYC3_Human0.93404937
92KLF5_20875108_ChIP-Seq_MESCs_Mouse0.93285760
93IRF8_22096565_ChIP-ChIP_GC-B_Human0.92997576
94P300_19829295_ChIP-Seq_ESCs_Human0.92590288
95PHF8_20622853_ChIP-Seq_HELA_Human0.91822884
96NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.91644628
97IRF1_19129219_ChIP-ChIP_H3396_Human0.91432746
98STAT3_1855785_ChIP-Seq_MESCs_Mouse0.91356857
99PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.91336549
100DCP1A_22483619_ChIP-Seq_HELA_Human0.90862233
101SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.89630672
102SOX17_20123909_ChIP-Seq_XEN_Mouse0.88706980
103ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.88560017
104NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.88327697
105MYC_18940864_ChIP-ChIP_HL60_Human0.88292908
106CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.87726006
107* PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.87443357
108CRX_20693478_ChIP-Seq_RETINA_Mouse0.86987974
109TBX20_22080862_ChIP-Seq_HEART_Mouse0.86574247
110TBX20_22328084_ChIP-Seq_HEART_Mouse0.86574247
111HNFA_21074721_ChIP-Seq_CACO-2_Human0.86028000
112PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.85201541
113ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.85178364
114CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.84745814
115AUTS2_25519132_ChIP-Seq_293T-REX_Human0.83978400
116ESR1_20079471_ChIP-ChIP_T-47D_Human0.80994895
117SALL4_18804426_ChIP-ChIP_XEN_Mouse0.77648096
118ESR1_15608294_ChIP-ChIP_MCF-7_Human0.75675056
119SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.75079667
120BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.75079624
121ESR2_21235772_ChIP-Seq_MCF-7_Human0.74775096
122PPAR_26484153_Chip-Seq_NCI-H1993_Human0.70657224
123RARA_24833708_ChIP-Seq_LIVER_Mouse0.67008339
124BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.66538901
125AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.66187806
126CEBPB_22108803_ChIP-Seq_LS180_Human0.65769748
127PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.64935142
128EGR1_19032775_ChIP-ChIP_M12_Human0.64440797
129RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.62701073
130RAD21_21589869_ChIP-Seq_MESCs_Mouse0.62401323
131LXR_22292898_ChIP-Seq_THP-1_Human0.62102130
132AR_20517297_ChIP-Seq_VCAP_Human0.59018400
133RARB_24833708_ChIP-Seq_LIVER_Mouse0.58753241
134Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.58448998
135TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.58338143
136TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.57816228
137GATA1_19941826_ChIP-Seq_K562_Human0.56696940
138NRF2_20460467_ChIP-Seq_MEFs_Mouse0.54030402
139NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.54030402
140KAP1_22055183_ChIP-Seq_ESCs_Mouse0.53978301
141ESR1_21235772_ChIP-Seq_MCF-7_Human0.53452768
142GATA1_19941827_ChIP-Seq_MEL_Mouse0.53236084
143CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.53211745
144EP300_21415370_ChIP-Seq_HL-1_Mouse0.52979891
145GATA2_19941826_ChIP-Seq_K562_Human0.52846527
146GATA6_25053715_ChIP-Seq_YYC3_Human0.52452098
147FOXO3_23340844_ChIP-Seq_DLD1_Human0.51464658
148PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.50406702
149FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.49922440
150FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.49273695
151* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.48892569
152TAF2_19829295_ChIP-Seq_ESCs_Human0.48636999
153E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.48560979
154CDX2_20551321_ChIP-Seq_CACO-2_Human0.48559142
155BCOR_27268052_Chip-Seq_Bcells_Human0.48267984
156GATA3_24758297_ChIP-Seq_MCF-7_Human0.48220619
157RACK7_27058665_Chip-Seq_MCF-7_Human0.47953343
158FOXA1_25552417_ChIP-Seq_VCAP_Human0.47761841
159ERG_20517297_ChIP-Seq_VCAP_Human0.46876655
160GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.46769354
161* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.44246802
162ESET_19884257_ChIP-Seq_ESCs_Mouse0.44140709
163SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.44001610
164CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.43449997
165BCL6_27268052_Chip-Seq_Bcells_Human0.43257104
166P53_21459846_ChIP-Seq_SAOS-2_Human0.42831274
167SRF_21415370_ChIP-Seq_HL-1_Mouse0.42704784
168NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.42511136
169* GATA4_21415370_ChIP-Seq_HL-1_Mouse0.42404980
170GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.41470581
171PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.41344540
172CBP_21632823_ChIP-Seq_H3396_Human0.41223748

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.33543184
2MP0005360_urolithiasis6.77766008
3MP0005085_abnormal_gallbladder_physiolo5.86890916
4MP0005365_abnormal_bile_salt5.66026677
5MP0008875_abnormal_xenobiotic_pharmacok4.49782532
6MP0003806_abnormal_nucleotide_metabolis4.15950396
7MP0003252_abnormal_bile_duct3.50631857
8MP0010329_abnormal_lipoprotein_level3.45321926
9MP0009840_abnormal_foam_cell3.14334440
10MP0005332_abnormal_amino_acid2.81810234
11MP0005083_abnormal_biliary_tract2.75345614
12MP0003195_calcinosis2.65847140
13MP0001666_abnormal_nutrient_absorption2.41770550
14MP0003191_abnormal_cellular_cholesterol2.30561750
15MP0002118_abnormal_lipid_homeostasis2.15371272
16MP0000609_abnormal_liver_physiology2.12109122
17MP0002837_dystrophic_cardiac_calcinosis1.99062235
18MP0004019_abnormal_vitamin_homeostasis1.93872364
19MP0005319_abnormal_enzyme/_coenzyme1.93078835
20MP0005670_abnormal_white_adipose1.71277330
21MP0004130_abnormal_muscle_cell1.67139810
22MP0005584_abnormal_enzyme/coenzyme_acti1.66975741
23MP0002138_abnormal_hepatobiliary_system1.63728841
24MP0000372_irregular_coat_pigmentation1.59893427
25MP0006036_abnormal_mitochondrial_physio1.58739720
26MP0001764_abnormal_homeostasis1.57392807
27MP0003941_abnormal_skin_development1.54959480
28MP0003718_maternal_effect1.49570143
29MP0005451_abnormal_body_composition1.48939607
30MP0003186_abnormal_redox_activity1.47634341
31MP0003868_abnormal_feces_composition1.47225032
32MP0009697_abnormal_copulation1.45577446
33MP0009643_abnormal_urine_homeostasis1.38953010
34MP0003567_abnormal_fetal_cardiomyocyte1.33246556
35MP0003705_abnormal_hypodermis_morpholog1.32726061
36MP0003011_delayed_dark_adaptation1.30420309
37MP0005330_cardiomyopathy1.24245356
38MP0005666_abnormal_adipose_tissue1.23829136
39MP0003656_abnormal_erythrocyte_physiolo1.23564130
40MP0003646_muscle_fatigue1.21193775
41MP0010368_abnormal_lymphatic_system1.18990455
42MP0002971_abnormal_brown_adipose1.16032171
43MP0000598_abnormal_liver_morphology1.14996742
44MP0005647_abnormal_sex_gland1.00003498
45MP0002090_abnormal_vision0.99981675
46MP0004957_abnormal_blastocyst_morpholog0.98978678
47MP0008877_abnormal_DNA_methylation0.98725158
48MP0009763_increased_sensitivity_to0.98644805
49MP0002938_white_spotting0.97660727
50MP0005379_endocrine/exocrine_gland_phen0.97196531
51MP0004084_abnormal_cardiac_muscle0.96445840
52MP0001986_abnormal_taste_sensitivity0.96435146
53MP0006035_abnormal_mitochondrial_morpho0.95064632
54MP0008058_abnormal_DNA_repair0.93454996
55MP0009764_decreased_sensitivity_to0.93375874
56MP0002078_abnormal_glucose_homeostasis0.92350393
57MP0005636_abnormal_mineral_homeostasis0.91366540
58MP0006054_spinal_hemorrhage0.88206837
59MP0008872_abnormal_physiological_respon0.87166088
60MP0005535_abnormal_body_temperature0.86961732
61MP0009642_abnormal_blood_homeostasis0.86912269
62MP0005266_abnormal_metabolism0.86724436
63MP0000604_amyloidosis0.86259192
64MP0003693_abnormal_embryo_hatching0.86182890
65MP0005334_abnormal_fat_pad0.85691644
66MP0008469_abnormal_protein_level0.85116462
67MP0005376_homeostasis/metabolism_phenot0.83519176
68MP0002254_reproductive_system_inflammat0.82571781
69MP0004036_abnormal_muscle_relaxation0.82147208
70MP0004215_abnormal_myocardial_fiber0.80857545
71MP0001756_abnormal_urination0.74631466
72MP0005385_cardiovascular_system_phenoty0.74380782
73MP0001544_abnormal_cardiovascular_syste0.74380782
74MP0001661_extended_life_span0.71997944
75MP0002269_muscular_atrophy0.70937414
76MP0008775_abnormal_heart_ventricle0.70089476
77MP0004185_abnormal_adipocyte_glucose0.69946528
78MP0008007_abnormal_cellular_replicative0.69437086
79MP0005084_abnormal_gallbladder_morpholo0.69335450
80MP0006138_congestive_heart_failure0.67143375
81MP0004087_abnormal_muscle_fiber0.66091418
82MP0003122_maternal_imprinting0.65994349
83MP0010630_abnormal_cardiac_muscle0.65051306
84MP0002102_abnormal_ear_morphology0.63540942
85MP0002638_abnormal_pupillary_reflex0.63501384
86MP0005408_hypopigmentation0.63164312
87MP0005448_abnormal_energy_balance0.62898394
88MP0002972_abnormal_cardiac_muscle0.62642689
89MP0000749_muscle_degeneration0.62485461
90MP0003221_abnormal_cardiomyocyte_apopto0.61559369
91MP0001853_heart_inflammation0.59670122
92MP0009115_abnormal_fat_cell0.58957187
93MP0005375_adipose_tissue_phenotype0.58264054
94MP0009765_abnormal_xenobiotic_induced0.57346056
95MP0000230_abnormal_systemic_arterial0.57226444
96MP0000751_myopathy0.56985167
97MP0010094_abnormal_chromosome_stability0.56157781
98MP0001727_abnormal_embryo_implantation0.55954815
99MP0002876_abnormal_thyroid_physiology0.55886663
100MP0002970_abnormal_white_adipose0.55448018
101MP0000516_abnormal_urinary_system0.54489655
102MP0005367_renal/urinary_system_phenotyp0.54489655
103MP0009672_abnormal_birth_weight0.54241496
104MP0002132_abnormal_respiratory_system0.53956643
105MP0002163_abnormal_gland_morphology0.53564416
106MP0005551_abnormal_eye_electrophysiolog0.53166794
107MP0005220_abnormal_exocrine_pancreas0.52966739
108MP0002136_abnormal_kidney_physiology0.52055663
109MP0003724_increased_susceptibility_to0.50934100
110MP0005620_abnormal_muscle_contractility0.50416917
111MP0005452_abnormal_adipose_tissue0.49583566
112MP0003690_abnormal_glial_cell0.48742182
113MP0009384_cardiac_valve_regurgitation0.47666543
114MP0002909_abnormal_adrenal_gland0.47251404
115MP0009053_abnormal_anal_canal0.46714365
116MP0003890_abnormal_embryonic-extraembry0.46500226
117MP0002332_abnormal_exercise_endurance0.46472286
118MP0004043_abnormal_pH_regulation0.46345406
119MP0003123_paternal_imprinting0.46066101
120MP0004782_abnormal_surfactant_physiolog0.44984553
121MP0002796_impaired_skin_barrier0.44593730
122MP0003953_abnormal_hormone_level0.44448896
123MP0001324_abnormal_eye_pigmentation0.44172321
124MP0004147_increased_porphyrin_level0.43433419
125MP0005165_increased_susceptibility_to0.43252379
126MP0003329_amyloid_beta_deposits0.42451682
127MP0001944_abnormal_pancreas_morphology0.41565364
128MP0003137_abnormal_impulse_conducting0.40790885
129MP0000249_abnormal_blood_vessel0.40053899
130MP0000639_abnormal_adrenal_gland0.39858626
131MP0008932_abnormal_embryonic_tissue0.39072285
132MP0005395_other_phenotype0.38496302
133MP0005464_abnormal_platelet_physiology0.36853581

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)6.08932374
2Abnormality of aromatic amino acid family metabolism (HP:0004338)6.04010839
3Intrahepatic cholestasis (HP:0001406)6.02377910
4Xanthomatosis (HP:0000991)5.52884565
5Abnormality of monocarboxylic acid metabolism (HP:0010996)5.43092984
6Hypobetalipoproteinemia (HP:0003563)5.33700326
7Prolonged partial thromboplastin time (HP:0003645)5.25976408
8Hyperammonemia (HP:0001987)4.96421565
9Hypoglycemic coma (HP:0001325)4.92061627
10Hyperlipoproteinemia (HP:0010980)4.81995200
11Hyperglycinuria (HP:0003108)4.64077547
12Ketosis (HP:0001946)4.55169565
13Abnormality of fatty-acid metabolism (HP:0004359)4.48772069
14Complement deficiency (HP:0004431)4.38168739
15Hypolipoproteinemia (HP:0010981)4.38016404
16Abnormality of serine family amino acid metabolism (HP:0010894)4.33927675
17Abnormality of glycine metabolism (HP:0010895)4.33927675
18Hyperglycinemia (HP:0002154)4.31134438
19Hypoalphalipoproteinemia (HP:0003233)4.12903925
20Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.01515619
21Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.90877377
22Epidermoid cyst (HP:0200040)3.88806113
23Joint hemorrhage (HP:0005261)3.82569507
24Abnormality of glutamine family amino acid metabolism (HP:0010902)3.81240861
25Ketoacidosis (HP:0001993)3.76501504
26Abnormality of aspartate family amino acid metabolism (HP:0010899)3.73231759
27Abnormality of dicarboxylic acid metabolism (HP:0010995)3.71886829
28Dicarboxylic aciduria (HP:0003215)3.71886829
29Abnormality of the common coagulation pathway (HP:0010990)3.67110254
30Abnormality of methionine metabolism (HP:0010901)3.62315378
31Abnormality of sulfur amino acid metabolism (HP:0004339)3.58761034
32Increased serum pyruvate (HP:0003542)3.39735604
33Fat malabsorption (HP:0002630)3.38432082
34Abnormality of the intrinsic pathway (HP:0010989)3.20535895
35Abnormality of serum amino acid levels (HP:0003112)3.16828821
36Abnormality of complement system (HP:0005339)3.16651029
37Hypercholesterolemia (HP:0003124)3.15486060
38Cerebral edema (HP:0002181)3.14059299
39Metabolic acidosis (HP:0001942)3.11370021
40Generalized aminoaciduria (HP:0002909)3.10934621
41Hyperbilirubinemia (HP:0002904)3.04214030
42Abnormality of pyrimidine metabolism (HP:0004353)3.03978078
43Myoglobinuria (HP:0002913)3.02770901
44Abnormality of glycolysis (HP:0004366)3.02694742
45Lethargy (HP:0001254)3.01586254
46Delayed CNS myelination (HP:0002188)2.88654608
47Conjugated hyperbilirubinemia (HP:0002908)2.83778255
48Hepatocellular necrosis (HP:0001404)2.81541216
49Acute necrotizing encephalopathy (HP:0006965)2.78317055
50Abnormality of vitamin metabolism (HP:0100508)2.77928852
51Abnormality of nucleobase metabolism (HP:0010932)2.73344663
52Skin nodule (HP:0200036)2.68656844
53Symptomatic seizures (HP:0011145)2.66803428
54Abnormality of alanine metabolism (HP:0010916)2.65904659
55Hyperalaninemia (HP:0003348)2.65904659
56Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.65904659
57Increased CSF lactate (HP:0002490)2.63220966
58Hepatocellular carcinoma (HP:0001402)2.62682408
59Hepatic necrosis (HP:0002605)2.60513103
60Rhabdomyolysis (HP:0003201)2.59099727
61Abnormality of purine metabolism (HP:0004352)2.58027956
62Abnormal mitochondria in muscle tissue (HP:0008316)2.56421175
63Abnormality of vitamin B metabolism (HP:0004340)2.55549362
64Renal cortical cysts (HP:0000803)2.55254749
65Mitochondrial inheritance (HP:0001427)2.54625687
66Nausea (HP:0002018)2.53595199
67Proximal tubulopathy (HP:0000114)2.50896166
68Steatorrhea (HP:0002570)2.50219906
69Hypoglycemic seizures (HP:0002173)2.49419871
70Vomiting (HP:0002013)2.48642103
71Myocardial infarction (HP:0001658)2.48187609
72Hyperphosphaturia (HP:0003109)2.41854174
73Reduced antithrombin III activity (HP:0001976)2.40995556
74Gout (HP:0001997)2.39743714
75Cholelithiasis (HP:0001081)2.39426959
76Abnormality of the vitamin B12 metabolism (HP:0004341)2.38629249
77Lactic acidosis (HP:0003128)2.38346360
78Abnormal gallbladder morphology (HP:0012437)2.36491185
79CNS demyelination (HP:0007305)2.32148292
80Spontaneous abortion (HP:0005268)2.31025747
81Progressive macrocephaly (HP:0004481)2.29711467
82Methylmalonic aciduria (HP:0012120)2.26699344
83Hyperinsulinemic hypoglycemia (HP:0000825)2.26501243
84Systemic lupus erythematosus (HP:0002725)2.25668656
85Hypochromic microcytic anemia (HP:0004840)2.23797583
86Methylmalonic acidemia (HP:0002912)2.22704902
87Pancreatic islet-cell hyperplasia (HP:0004510)2.22462734
88Cerebral palsy (HP:0100021)2.22398378
89Increased muscle lipid content (HP:0009058)2.19255784
90Vascular calcification (HP:0004934)2.18551322
91Late onset (HP:0003584)2.16342933
92Pancreatitis (HP:0001733)2.16302182
93Abnormality of urine glucose concentration (HP:0011016)2.14977858
94Glycosuria (HP:0003076)2.14977858
95Lipid accumulation in hepatocytes (HP:0006561)2.14813388
96Neonatal onset (HP:0003623)2.13277059
97Hypothermia (HP:0002045)2.13237594
98Increased serum lactate (HP:0002151)2.12899988
99Abnormal cartilage morphology (HP:0002763)2.10942287
100Abnormality of proline metabolism (HP:0010907)2.10557722
101Hydroxyprolinuria (HP:0003080)2.10557722
102Neoplasm of the adrenal gland (HP:0100631)2.09262926
103Megaloblastic anemia (HP:0001889)2.08314655
104Acute encephalopathy (HP:0006846)2.06496544
105Acanthocytosis (HP:0001927)2.05527821
106Spastic diplegia (HP:0001264)2.05488267
107Esophageal varix (HP:0002040)2.03798135
108Irritability (HP:0000737)2.01493963
109Abnormal gallbladder physiology (HP:0012438)2.00325133
110Cholecystitis (HP:0001082)2.00325133
111Right ventricular cardiomyopathy (HP:0011663)2.00059587
112Sensorimotor neuropathy (HP:0007141)1.98869499
113Increased hepatocellular lipid droplets (HP:0006565)1.97893655
114Cardiovascular calcification (HP:0011915)1.97602188
115Hyperglycemia (HP:0003074)1.97024735
116Brushfield spots (HP:0001088)1.96161581
117Respiratory failure (HP:0002878)1.96134447
118Malnutrition (HP:0004395)1.95178784
119Ragged-red muscle fibers (HP:0003200)1.94975648
120Hypertriglyceridemia (HP:0002155)1.94937249
121Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.92973326
122Decreased activity of mitochondrial respiratory chain (HP:0008972)1.92973326
123Palpitations (HP:0001962)1.90872884
124Mitral stenosis (HP:0001718)1.90492086
125Rickets (HP:0002748)1.89559623
126Enlarged kidneys (HP:0000105)1.89048287
127Elevated hepatic transaminases (HP:0002910)1.87067826
128Hyperuricemia (HP:0002149)1.86009842
129Increased purine levels (HP:0004368)1.86009842
130Abnormality of the gallbladder (HP:0005264)1.85972609
131Glomerulonephritis (HP:0000099)1.85589412
132Exercise-induced myalgia (HP:0003738)1.85499349
133Amyloidosis (HP:0011034)1.83969033

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.29473035
2ACVR1B4.54621020
3SIK13.54393788
4ERN13.43848023
5PKN23.27615791
6FGFR43.23675139
7TRIB33.19391755
8PBK3.01118197
9STK162.73858247
10WNK32.66534262
11PDK32.61555402
12PDK42.61555402
13MST42.47008578
14EIF2AK32.40114928
15INSRR2.37181753
16ZAK2.14975544
17TNIK2.13248240
18FLT32.08856192
19TTN1.87941088
20BMPR1B1.86654435
21MYLK1.85531608
22PLK41.83830372
23OBSCN1.83767544
24NUAK11.80156207
25MAP3K121.76768182
26TIE11.73331941
27BUB11.72473937
28TRIM281.71393609
29NEK91.67383156
30TTK1.66914195
31KDR1.66860568
32GRK11.65808166
33EIF2AK11.64273602
34MST1R1.63112121
35PLK31.61281247
36OXSR11.59504378
37PINK11.58082761
38LMTK21.57628565
39MAP4K21.57356977
40PDK21.55122959
41VRK21.54376761
42SRPK11.54115288
43MAPK111.52724930
44TAOK31.50239451
45ERBB41.46572991
46MKNK21.42382793
47MAP2K31.41433122
48PIK3CG1.41091422
49NEK11.35711630
50MKNK11.33635390
51TYK21.33249192
52TSSK61.33060321
53LATS11.32955730
54PRKAA21.30639448
55MAP3K31.22078050
56STK38L1.21974787
57MAP2K41.21338339
58CDC71.20907353
59PTK61.19218459
60MAP3K71.13715139
61ABL21.10755108
62VRK11.07044388
63TGFBR21.06335342
64CAMK1D1.05975059
65NLK1.05477865
66PIK3CA1.04815323
67BRSK21.01741503
68CDK191.01293052
69PHKG21.01122030
70PHKG11.01122030
71FRK0.99433874
72WEE10.98168838
73PLK10.95356052
74TBK10.94219476
75JAK20.92674949
76CSNK1G10.89646396
77MAPK120.89280177
78STK240.88759366
79PRKAA10.85622399
80RIPK10.83909629
81JAK10.80830724
82MAP3K100.80477930
83NME10.79908880
84LIMK10.79804745
85STK390.79697143
86ADRBK20.78930151
87MAP3K110.78862792
88FER0.76631508
89NME20.75504797
90PLK20.71891092
91IRAK30.71313651
92PRKCE0.70974807
93PRKACG0.70904375
94MAPK40.70733012
95TESK20.69674097
96MAP3K50.69244865
97CSNK2A10.65309662
98MAP2K60.64187971
99CSNK1G30.62504410
100CSNK1G20.62339840
101CAMK2D0.61288094
102MUSK0.60673221
103STK30.60603252
104CSNK2A20.59537094
105FGFR20.58120984
106CDK60.57747561
107ERBB20.56745626
108PDPK10.56258270
109DAPK10.55666063
110EPHB10.54306785
111PRKCG0.53828974
112CDK40.53355088
113TGFBR10.51103674
114CASK0.49344110
115SGK30.48842320
116MET0.48361268
117CAMK2G0.47618822
118GRK60.47129664
119PRKD10.46959162
120FGFR30.46766508
121CSNK1A10.46313275
122ATR0.45463100
123EPHA30.45175607
124TAF10.43179332
125GSK3A0.42376324
126ATM0.41649267
127DAPK20.41389542
128EIF2AK20.40921279
129TAOK20.40836698
130PDK10.40605581
131CAMK40.40474304
132PRKCZ0.40465175
133AURKB0.38950468
134PDGFRA0.38917073
135CSK0.38786529
136TESK10.38466233
137DYRK20.38372057
138PRKG10.38341405
139MAPKAPK30.37981588
140LRRK20.37915576
141MAP2K10.37499431
142STK40.37462053
143CSNK1E0.36967443
144PAK30.36240937
145FGFR10.36073723
146PAK40.35353801
147DYRK1B0.34969105
148PRKACA0.34886765
149ILK0.34638422
150BCR0.34623007
151PRKCA0.34574628
152MAPK70.33316578
153MTOR0.32615993
154IGF1R0.32002609
155WNK40.31973224
156IKBKE0.31972793
157PRKCQ0.31474137
158MAP3K140.29112780
159ERBB30.28204079
160AKT20.27472350
161EPHB20.26186733
162ZAP700.25371170
163GRK70.24833269
164SGK20.24760503
165PRKACB0.23847002
166PRKG20.23390181
167MAP4K10.22559811
168CSF1R0.22068426
169CAMK1G0.21179146

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.90051285
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.21362866
3Nitrogen metabolism_Homo sapiens_hsa009103.08599408
4* Fatty acid degradation_Homo sapiens_hsa000713.08340653
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.94485190
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.87748278
7* Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.83867015
8Propanoate metabolism_Homo sapiens_hsa006402.79229668
9Arginine biosynthesis_Homo sapiens_hsa002202.73321487
10Tryptophan metabolism_Homo sapiens_hsa003802.63014287
11Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.56589695
122-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.39332242
13Complement and coagulation cascades_Homo sapiens_hsa046102.31095565
14* Fatty acid metabolism_Homo sapiens_hsa012122.29729407
15Butanoate metabolism_Homo sapiens_hsa006502.28518217
16Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.27995486
17PPAR signaling pathway_Homo sapiens_hsa033202.15565130
18Peroxisome_Homo sapiens_hsa041462.12749508
19Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.06168288
20Pentose and glucuronate interconversions_Homo sapiens_hsa000402.05535301
21Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.88410310
22beta-Alanine metabolism_Homo sapiens_hsa004101.85377610
23Pyruvate metabolism_Homo sapiens_hsa006201.79420514
24Carbon metabolism_Homo sapiens_hsa012001.71787438
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.69939159
26Chemical carcinogenesis_Homo sapiens_hsa052041.69608540
27Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.69170209
28Proteasome_Homo sapiens_hsa030501.64334426
29Histidine metabolism_Homo sapiens_hsa003401.61787409
30Caffeine metabolism_Homo sapiens_hsa002321.60239852
31Steroid hormone biosynthesis_Homo sapiens_hsa001401.57073380
32Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.54310011
33Drug metabolism - other enzymes_Homo sapiens_hsa009831.53393695
34Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.51817231
35Retinol metabolism_Homo sapiens_hsa008301.48523193
36Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.47303498
37Phenylalanine metabolism_Homo sapiens_hsa003601.45641732
38* Fatty acid elongation_Homo sapiens_hsa000621.44577518
39Selenocompound metabolism_Homo sapiens_hsa004501.42593483
40Staphylococcus aureus infection_Homo sapiens_hsa051501.41261026
41Biosynthesis of amino acids_Homo sapiens_hsa012301.36738834
42Starch and sucrose metabolism_Homo sapiens_hsa005001.35611312
43Tyrosine metabolism_Homo sapiens_hsa003501.31857228
44Bile secretion_Homo sapiens_hsa049761.28123578
45Sulfur metabolism_Homo sapiens_hsa009201.26570279
46Fat digestion and absorption_Homo sapiens_hsa049751.23698555
47Cysteine and methionine metabolism_Homo sapiens_hsa002701.21366718
48Protein export_Homo sapiens_hsa030601.11154196
49Folate biosynthesis_Homo sapiens_hsa007901.09617827
50ABC transporters_Homo sapiens_hsa020101.05098957
51Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.98140546
52Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.96394864
53Arginine and proline metabolism_Homo sapiens_hsa003300.94931082
54Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.90671755
55Lysine degradation_Homo sapiens_hsa003100.90042166
56Sulfur relay system_Homo sapiens_hsa041220.87300772
57Fatty acid biosynthesis_Homo sapiens_hsa000610.86188487
58Cyanoamino acid metabolism_Homo sapiens_hsa004600.84488117
59Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.81871891
60Glycerolipid metabolism_Homo sapiens_hsa005610.78778173
61Steroid biosynthesis_Homo sapiens_hsa001000.78608427
62Vitamin digestion and absorption_Homo sapiens_hsa049770.75381973
63Vitamin B6 metabolism_Homo sapiens_hsa007500.74133991
64Pentose phosphate pathway_Homo sapiens_hsa000300.72774664
65Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.72090382
66Glutathione metabolism_Homo sapiens_hsa004800.71287595
67Maturity onset diabetes of the young_Homo sapiens_hsa049500.69450658
68Mismatch repair_Homo sapiens_hsa034300.68703599
69One carbon pool by folate_Homo sapiens_hsa006700.60177377
70* Metabolic pathways_Homo sapiens_hsa011000.53072092
71Mineral absorption_Homo sapiens_hsa049780.51901932
72Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.51127877
73Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.46845087
74Galactose metabolism_Homo sapiens_hsa000520.45957090
75Non-homologous end-joining_Homo sapiens_hsa034500.45356026
76Adipocytokine signaling pathway_Homo sapiens_hsa049200.43169967
77DNA replication_Homo sapiens_hsa030300.42219724
78RNA polymerase_Homo sapiens_hsa030200.41824305
79Insulin resistance_Homo sapiens_hsa049310.41399874
80Fructose and mannose metabolism_Homo sapiens_hsa000510.41298538
81Homologous recombination_Homo sapiens_hsa034400.39898333
82Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.37531620
83Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.31448129
84Pyrimidine metabolism_Homo sapiens_hsa002400.28927769
85Ether lipid metabolism_Homo sapiens_hsa005650.27156427
86Parkinsons disease_Homo sapiens_hsa050120.26863603
87Oxidative phosphorylation_Homo sapiens_hsa001900.26160556
88Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.25921724
89Glucagon signaling pathway_Homo sapiens_hsa049220.25200249
90Base excision repair_Homo sapiens_hsa034100.24232510
91Purine metabolism_Homo sapiens_hsa002300.23075028
92alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.22863613
93AMPK signaling pathway_Homo sapiens_hsa041520.19733804
94Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.19226094
95Nucleotide excision repair_Homo sapiens_hsa034200.17032355
96Linoleic acid metabolism_Homo sapiens_hsa005910.15287257
97Glycerophospholipid metabolism_Homo sapiens_hsa005640.15228375
98RNA degradation_Homo sapiens_hsa030180.14748113
99Prion diseases_Homo sapiens_hsa050200.14667998
100Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.13634232
101Alzheimers disease_Homo sapiens_hsa050100.09455579
102Insulin signaling pathway_Homo sapiens_hsa049100.06692622
103Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.04034608
104Cardiac muscle contraction_Homo sapiens_hsa042600.03669639
105Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.00449136
106Systemic lupus erythematosus_Homo sapiens_hsa05322-0.2232520
107Hepatitis C_Homo sapiens_hsa05160-0.2215981
108Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.2114567
109Amoebiasis_Homo sapiens_hsa05146-0.2053876
110Regulation of autophagy_Homo sapiens_hsa04140-0.1859181
111Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.1738690
112Dilated cardiomyopathy_Homo sapiens_hsa05414-0.1676671
113Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410-0.1420979
114Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.1379550
115Renin-angiotensin system_Homo sapiens_hsa04614-0.1101090
116Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0932330
117Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0781279
118Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.0520610
119Huntingtons disease_Homo sapiens_hsa05016-0.0266718

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