ACACB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. ACC-beta is thought to control fatty acid oxidation by means of the ability of malonyl-CoA to inhibit carnitine-palmitoyl-CoA transferase I, the rate-limiting step in fatty acid uptake and oxidation by mitochondria. ACC-beta may be involved in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. There is evidence for the presence of two ACC-beta isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* carnitine shuttle (GO:0006853)5.81900626
2* fatty acid transmembrane transport (GO:1902001)5.78119510
3regulation of sequestering of triglyceride (GO:0010889)5.74802673
4fatty acid beta-oxidation (GO:0006635)5.38470803
5tricarboxylic acid cycle (GO:0006099)5.37834005
6lysine catabolic process (GO:0006554)5.15114568
7lysine metabolic process (GO:0006553)5.15114568
82-oxoglutarate metabolic process (GO:0006103)4.95319591
9alpha-linolenic acid metabolic process (GO:0036109)4.94160842
10positive regulation of fatty acid beta-oxidation (GO:0032000)4.74737574
11fatty acid catabolic process (GO:0009062)4.73457959
12fatty acid oxidation (GO:0019395)4.72644561
13regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.68570591
14* acetyl-CoA metabolic process (GO:0006084)4.68050169
15diacylglycerol metabolic process (GO:0046339)4.66382960
16regulation of fatty acid oxidation (GO:0046320)4.64138107
17lipid oxidation (GO:0034440)4.63179298
18regulation of triglyceride catabolic process (GO:0010896)4.46485255
19positive regulation of fatty acid oxidation (GO:0046321)4.45174437
20sarcomere organization (GO:0045214)4.41194255
21valine metabolic process (GO:0006573)4.39190715
22glycerolipid catabolic process (GO:0046503)4.36719150
23negative regulation of fatty acid biosynthetic process (GO:0045717)4.36232230
24fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.35121479
25brown fat cell differentiation (GO:0050873)4.32341704
26L-phenylalanine metabolic process (GO:0006558)4.31293270
27erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.31293270
28* carnitine transmembrane transport (GO:1902603)4.31257665
29NADH metabolic process (GO:0006734)4.28167849
30L-phenylalanine catabolic process (GO:0006559)4.27660533
31erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.27660533
32aspartate family amino acid catabolic process (GO:0009068)4.27195427
33branched-chain amino acid catabolic process (GO:0009083)4.26194340
34short-chain fatty acid metabolic process (GO:0046459)4.23224632
35regulation of acyl-CoA biosynthetic process (GO:0050812)4.19694107
36monocarboxylic acid catabolic process (GO:0072329)4.18573487
37cellular response to epinephrine stimulus (GO:0071872)4.11897605
38glyoxylate metabolic process (GO:0046487)4.05727339
39amino-acid betaine metabolic process (GO:0006577)4.03568178
40* amino-acid betaine transport (GO:0015838)4.03099686
41* carnitine transport (GO:0015879)4.03099686
42branched-chain amino acid metabolic process (GO:0009081)4.02036970
43* biotin metabolic process (GO:0006768)3.96972007
44negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.96875964
45sulfur amino acid catabolic process (GO:0000098)3.96002656
46triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.95107990
47carnitine metabolic process (GO:0009437)3.94481087
48tricarboxylic acid metabolic process (GO:0072350)3.93262627
49lipid storage (GO:0019915)3.89865783
50regulation of fatty acid beta-oxidation (GO:0031998)3.88643586
51cardiac myofibril assembly (GO:0055003)3.86017434
52response to epinephrine (GO:0071871)3.84638466
53ethanol metabolic process (GO:0006067)3.83772261
54fatty acid homeostasis (GO:0055089)3.81921227
55kynurenine metabolic process (GO:0070189)3.81343092
56regulation of cofactor metabolic process (GO:0051193)3.81027966
57regulation of coenzyme metabolic process (GO:0051196)3.81027966
58triglyceride biosynthetic process (GO:0019432)3.80335473
59cellular ketone body metabolic process (GO:0046950)3.77250691
60positive regulation of lipid catabolic process (GO:0050996)3.76664476
61actin-myosin filament sliding (GO:0033275)3.75401683
62muscle filament sliding (GO:0030049)3.75401683
63neutral lipid biosynthetic process (GO:0046460)3.73546829
64acylglycerol biosynthetic process (GO:0046463)3.73546829
65ethanol oxidation (GO:0006069)3.69713107
66oxaloacetate metabolic process (GO:0006107)3.69516604
67acylglycerol homeostasis (GO:0055090)3.68479554
68triglyceride homeostasis (GO:0070328)3.68479554
69myofibril assembly (GO:0030239)3.64723161
70lipid particle organization (GO:0034389)3.64531381
71aromatic amino acid family catabolic process (GO:0009074)3.64314422
72negative regulation of fatty acid metabolic process (GO:0045922)3.64027463
73regulation of cholesterol storage (GO:0010885)3.63649971
74succinate metabolic process (GO:0006105)3.63233908
75negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.61208119
76phospholipid homeostasis (GO:0055091)3.60718497
77triglyceride catabolic process (GO:0019433)3.60037214
78triglyceride metabolic process (GO:0006641)3.54840334
79regulation of skeletal muscle contraction (GO:0014819)3.54631814
80* thioester biosynthetic process (GO:0035384)3.54030451
81* acyl-CoA biosynthetic process (GO:0071616)3.54030451
82positive regulation of glycolytic process (GO:0045821)3.52944747
83regulation of glycogen (starch) synthase activity (GO:2000465)3.52301619
84white fat cell differentiation (GO:0050872)3.50558698
85exogenous drug catabolic process (GO:0042738)3.49590885
86serine family amino acid catabolic process (GO:0009071)3.49554694
87low-density lipoprotein particle clearance (GO:0034383)3.49074536
88positive regulation of cholesterol efflux (GO:0010875)3.47911087
89neutral lipid catabolic process (GO:0046461)3.46047479
90acylglycerol catabolic process (GO:0046464)3.46047479
91carboxylic acid catabolic process (GO:0046395)3.43494484
92organic acid catabolic process (GO:0016054)3.43494484
93creatine metabolic process (GO:0006600)3.43030552
94negative regulation of potassium ion transmembrane transport (GO:1901380)3.42764502
95positive regulation of fatty acid metabolic process (GO:0045923)3.41709160
96plasma lipoprotein particle clearance (GO:0034381)3.40424266
97response to phenylpropanoid (GO:0080184)3.37327306
98bundle of His cell to Purkinje myocyte communication (GO:0086069)3.36353161
99acylglycerol metabolic process (GO:0006639)3.34161832
100alpha-amino acid catabolic process (GO:1901606)3.33345573
101positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.30527088
102positive regulation of cholesterol transport (GO:0032376)3.29390585
103positive regulation of sterol transport (GO:0032373)3.29390585
104neutral lipid metabolic process (GO:0006638)3.29144097
105bile acid biosynthetic process (GO:0006699)3.28663469
106drug catabolic process (GO:0042737)3.28013247
107complement activation, alternative pathway (GO:0006957)3.27251816
108positive regulation of triglyceride metabolic process (GO:0090208)3.24968831
109regulation of triglyceride metabolic process (GO:0090207)3.24917920
110regulation of sulfur metabolic process (GO:0042762)3.24704989
111plasma membrane repair (GO:0001778)3.24220119
112ketone body metabolic process (GO:1902224)3.23081383
113glycogen catabolic process (GO:0005980)3.23056481
114glycerol metabolic process (GO:0006071)3.22811587
115cellular amino acid catabolic process (GO:0009063)3.22409659
116primary alcohol metabolic process (GO:0034308)3.20307376
117regulation of fatty acid metabolic process (GO:0019217)3.20015103
118regulation of triglyceride biosynthetic process (GO:0010866)3.19380002
119cysteine metabolic process (GO:0006534)3.18814940
120urea metabolic process (GO:0019627)3.17778351
121urea cycle (GO:0000050)3.17778351
122* thioester metabolic process (GO:0035383)3.17567066
123* acyl-CoA metabolic process (GO:0006637)3.17567066
124epoxygenase P450 pathway (GO:0019373)3.17058635
125tryptophan catabolic process (GO:0006569)3.16248137
126indole-containing compound catabolic process (GO:0042436)3.16248137
127indolalkylamine catabolic process (GO:0046218)3.16248137
128cardiac muscle contraction (GO:0060048)3.16228600
129cardiac muscle cell development (GO:0055013)3.16156952
130positive regulation of lipid storage (GO:0010884)3.15614197
131negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)3.06650955
132regulation of cAMP-dependent protein kinase activity (GO:2000479)3.03698450
133growth hormone receptor signaling pathway (GO:0060396)3.03523614
134cGMP-mediated signaling (GO:0019934)2.99020443
135regulation of protein activation cascade (GO:2000257)2.97199740
136CDP-diacylglycerol biosynthetic process (GO:0016024)2.96363625
137regulation of lipid storage (GO:0010883)2.96002292
138positive regulation of glomerulus development (GO:0090193)2.95599755
139regulation of complement activation (GO:0030449)2.94821424
140regulation of macrophage derived foam cell differentiation (GO:0010743)2.94442084
141negative regulation of granulocyte differentiation (GO:0030853)2.93481599
142regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.92521894
143transcytosis (GO:0045056)2.91651014
144positive regulation of triglyceride lipase activity (GO:0061365)2.89095761
145positive regulation of lipoprotein lipase activity (GO:0051006)2.89095761
146polyol transport (GO:0015791)2.84429535
147alditol metabolic process (GO:0019400)2.81516486
148negative regulation of lipase activity (GO:0060192)2.80318178
149protein heterotrimerization (GO:0070208)2.79927648
150negative regulation of lipid catabolic process (GO:0050995)2.78302318
151cellular response to growth hormone stimulus (GO:0071378)2.76998455
152omega-hydroxylase P450 pathway (GO:0097267)2.74320235
153regulation of lipid catabolic process (GO:0050994)2.74310134
154CDP-diacylglycerol metabolic process (GO:0046341)2.74026758
155phosphatidic acid metabolic process (GO:0046473)2.71820563
156phosphatidic acid biosynthetic process (GO:0006654)2.71820563
157regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.71299906

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse9.17606514
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.97351629
3* RXR_22158963_ChIP-Seq_LIVER_Mouse5.92594102
4PPARA_22158963_ChIP-Seq_LIVER_Mouse5.33326245
5* LXR_22158963_ChIP-Seq_LIVER_Mouse4.79090761
6TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse4.58467717
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.12753695
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.72774620
9EGR1_23403033_ChIP-Seq_LIVER_Mouse3.21582203
10CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.71246659
11ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.69531975
12EZH2_22144423_ChIP-Seq_EOC_Human2.62434531
13CLOCK_20551151_ChIP-Seq_293T_Human2.57559134
14RARG_19884340_ChIP-ChIP_MEFs_Mouse2.04129255
15* TBX20_22080862_ChIP-Seq_HEART_Mouse1.98508000
16* TBX20_22328084_ChIP-Seq_HEART_Mouse1.98508000
17CDX2_19796622_ChIP-Seq_MESCs_Mouse1.89221562
18THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.76397197
19GBX2_23144817_ChIP-Seq_PC3_Human1.74969317
20TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.72770359
21CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.72443580
22* ZNF263_19887448_ChIP-Seq_K562_Human1.71511247
23ESR1_20079471_ChIP-ChIP_T-47D_Human1.71284345
24NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.59810502
25ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.59000014
26EP300_21415370_ChIP-Seq_HL-1_Mouse1.58049095
27PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.56257049
28STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.54986194
29PIAS1_25552417_ChIP-Seq_VCAP_Human1.54147814
30ESR2_21235772_ChIP-Seq_MCF-7_Human1.52066159
31PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.46083967
32RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.43035495
33CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.42708616
34FOXA2_19822575_ChIP-Seq_HepG2_Human1.37142820
35STAT3_1855785_ChIP-Seq_MESCs_Mouse1.36181679
36GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.32418317
37LXR_22292898_ChIP-Seq_THP-1_Human1.30525332
38DROSHA_22980978_ChIP-Seq_HELA_Human1.29236081
39TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.27868214
40HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.23332585
41BCAT_22108803_ChIP-Seq_LS180_Human1.22606568
42AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.21866998
43SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.21711207
44ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.21461564
45PPAR_26484153_Chip-Seq_NCI-H1993_Human1.18436630
46SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.18378991
47SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.16754347
48MTF2_20144788_ChIP-Seq_MESCs_Mouse1.15375347
49CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.13367025
50STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.13185817
51RACK7_27058665_Chip-Seq_MCF-7_Human1.12298821
52NR3C1_23031785_ChIP-Seq_PC12_Mouse1.12179210
53SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.11757121
54GATA2_21666600_ChIP-Seq_HMVEC_Human1.10630438
55EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.10592096
56AHR_22903824_ChIP-Seq_MCF-7_Human1.07131516
57PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.06923778
58RNF2_18974828_ChIP-Seq_MESCs_Mouse1.03993580
59EZH2_18974828_ChIP-Seq_MESCs_Mouse1.03993580
60SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.03909055
61PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.03339893
62CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.03309727
63* HNF4A_19822575_ChIP-Seq_HepG2_Human1.02420652
64GATA4_21415370_ChIP-Seq_HL-1_Mouse1.02126865
65VDR_22108803_ChIP-Seq_LS180_Human1.01885967
66* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.01045747
67WT1_25993318_ChIP-Seq_PODOCYTE_Human1.01035383
68SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.00997851
69NR3C1_21868756_ChIP-Seq_MCF10A_Human0.99093664
70CJUN_26792858_Chip-Seq_BT549_Human0.98800469
71MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.96834720
72NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.95763983
73NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.95573633
74SOX2_27498859_Chip-Seq_STOMACH_Mouse0.94979933
75AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.94185169
76EZH2_27294783_Chip-Seq_ESCs_Mouse0.94121510
77ZNF217_24962896_ChIP-Seq_MCF-7_Human0.94101191
78STAT3_23295773_ChIP-Seq_U87_Human0.93035234
79EED_16625203_ChIP-ChIP_MESCs_Mouse0.92377101
80* NRF2_20460467_ChIP-Seq_MEFs_Mouse0.92328666
81* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.92328666
82* SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.92287857
83NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.92190884
84CTNNB1_20460455_ChIP-Seq_HCT116_Human0.91406435
85IGF1R_20145208_ChIP-Seq_DFB_Human0.91378251
86KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.90944893
87RXRA_24833708_ChIP-Seq_LIVER_Mouse0.90663469
88ARNT_22903824_ChIP-Seq_MCF-7_Human0.90242644
89GATA1_22025678_ChIP-Seq_K562_Human0.90198050
90ESR1_21235772_ChIP-Seq_MCF-7_Human0.89477954
91FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.89118683
92RXR_22108803_ChIP-Seq_LS180_Human0.88542439
93JARID2_20075857_ChIP-Seq_MESCs_Mouse0.87725699
94* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.87679875
95SMAD4_21799915_ChIP-Seq_A2780_Human0.87009949
96GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85412950
97* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.84845639
98ATF3_27146783_Chip-Seq_COLON_Human0.84162792
99ZFP57_27257070_Chip-Seq_ESCs_Mouse0.83601244
100GATA1_19941826_ChIP-Seq_K562_Human0.83351992
101KDM2B_26808549_Chip-Seq_SUP-B15_Human0.83136975
102NFIB_24661679_ChIP-Seq_LUNG_Mouse0.82829421
103SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.81570487
104CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.81450464
105PCGF2_27294783_Chip-Seq_NPCs_Mouse0.81235620
106SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.81016281
107TP63_17297297_ChIP-ChIP_HaCaT_Human0.80752058
108BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.80500063
109PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.80494909
110* TCF4_23295773_ChIP-Seq_U87_Human0.80292659
111* CBP_21632823_ChIP-Seq_H3396_Human0.80247396
112AR_25329375_ChIP-Seq_VCAP_Human0.79754528
113ELK3_25401928_ChIP-Seq_HUVEC_Human0.79640284
114EZH2_27304074_Chip-Seq_ESCs_Mouse0.79249289
115TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.79240429
116CTCF_27219007_Chip-Seq_Bcells_Human0.79110536
117MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.78619169
118SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.78244043
119POU3F2_20337985_ChIP-ChIP_501MEL_Human0.78046819
120SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77631622
121* TP63_22573176_ChIP-Seq_HFKS_Human0.76923243
122SOX2_21211035_ChIP-Seq_LN229_Gbm0.76006262
123* BCOR_27268052_Chip-Seq_Bcells_Human0.75901423
124* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.75786708
125CTCF_21964334_ChIP-Seq_BJAB-B_Human0.75763636
126PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.74372538
127MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.73874239
128SMAD4_21741376_ChIP-Seq_HESCs_Human0.73667381
129* P68_20966046_ChIP-Seq_HELA_Human0.73600868
130HIF1A_21447827_ChIP-Seq_MCF-7_Human0.72216573
131RNF2_27304074_Chip-Seq_ESCs_Mouse0.71924156
132CREB1_26743006_Chip-Seq_LNCaP_Human0.71582103
133PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.71398324
134P300_27058665_Chip-Seq_ZR-75-30cells_Human0.71299636
135RUNX1_27514584_Chip-Seq_MCF-7_Human0.70832971
136GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.70387836
137KDM2B_26808549_Chip-Seq_DND41_Human0.70156816
138FOXO3_23340844_ChIP-Seq_DLD1_Human0.69834771
139P63_26484246_Chip-Seq_KERATINOCYTES_Human0.69718370
140TET1_21451524_ChIP-Seq_MESCs_Mouse0.69611123
141BCL6_27268052_Chip-Seq_Bcells_Human0.68204080
142TRIM28_21343339_ChIP-Seq_HEK293_Human0.67185044
143ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.67004362
144CTCF_21964334_Chip-Seq_Bcells_Human0.66575491
145* AUTS2_25519132_ChIP-Seq_293T-REX_Human0.65942823
146POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.65917298
147SPI1_20517297_ChIP-Seq_HL60_Human0.65710724
148SOX9_24532713_ChIP-Seq_HFSC_Mouse0.65347084
149* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.63910107
150GATA2_19941826_ChIP-Seq_K562_Human0.63826715
151RARA_24833708_ChIP-Seq_LIVER_Mouse0.63335405
152E2F1_20622854_ChIP-Seq_HELA_Human0.63075783
153RAD21_21589869_ChIP-Seq_MESCs_Mouse0.62617260
154CEBPB_22108803_ChIP-Seq_LS180_Human0.62447399
155CSB_26484114_Chip-Seq_FIBROBLAST_Human0.60886472
156ESR1_15608294_ChIP-ChIP_MCF-7_Human0.60865175
157GATA1_19941827_ChIP-Seq_MEL_Mouse0.60131747
158KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.59638499
159SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.59151027

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis5.20295703
2MP0003646_muscle_fatigue4.22901939
3MP0002139_abnormal_hepatobiliary_system4.19588064
4MP0005085_abnormal_gallbladder_physiolo3.67520985
5MP0005365_abnormal_bile_salt3.66583945
6MP0005360_urolithiasis3.64676760
7MP0005670_abnormal_white_adipose3.57893991
8MP0004130_abnormal_muscle_cell3.49179677
9MP0000751_myopathy3.37916025
10MP0004084_abnormal_cardiac_muscle3.12120283
11MP0005330_cardiomyopathy2.82025596
12MP0005666_abnormal_adipose_tissue2.79030249
13MP0004215_abnormal_myocardial_fiber2.71534741
14MP0004036_abnormal_muscle_relaxation2.62443056
15MP0003806_abnormal_nucleotide_metabolis2.59097622
16MP0000749_muscle_degeneration2.52748213
17MP0010329_abnormal_lipoprotein_level2.49084960
18MP0004087_abnormal_muscle_fiber2.27452041
19MP0008875_abnormal_xenobiotic_pharmacok2.21057338
20MP0004185_abnormal_adipocyte_glucose2.15763326
21MP0002876_abnormal_thyroid_physiology2.11120540
22MP0002269_muscular_atrophy2.02737149
23MP0003252_abnormal_bile_duct1.97763442
24MP0002971_abnormal_brown_adipose1.96842914
25MP0003011_delayed_dark_adaptation1.93621075
26MP0008775_abnormal_heart_ventricle1.91156344
27MP0005332_abnormal_amino_acid1.86662163
28MP0009840_abnormal_foam_cell1.86641632
29* MP0002118_abnormal_lipid_homeostasis1.86422985
30MP0000750_abnormal_muscle_regeneration1.84773362
31* MP0006036_abnormal_mitochondrial_physio1.83688765
32MP0005083_abnormal_biliary_tract1.83333564
33MP0010630_abnormal_cardiac_muscle1.82044270
34MP0005620_abnormal_muscle_contractility1.81073828
35MP0002972_abnormal_cardiac_muscle1.79360862
36MP0005375_adipose_tissue_phenotype1.79299632
37MP0005385_cardiovascular_system_phenoty1.73970009
38MP0001544_abnormal_cardiovascular_syste1.73970009
39MP0003705_abnormal_hypodermis_morpholog1.68920113
40MP0003137_abnormal_impulse_conducting1.67854862
41MP0006138_congestive_heart_failure1.64850665
42* MP0002106_abnormal_muscle_physiology1.63002743
43MP0002638_abnormal_pupillary_reflex1.61918704
44MP0000609_abnormal_liver_physiology1.59284797
45MP0003191_abnormal_cellular_cholesterol1.56747178
46MP0000747_muscle_weakness1.54152680
47MP0000759_abnormal_skeletal_muscle1.51952263
48MP0004145_abnormal_muscle_electrophysio1.45514623
49MP0003221_abnormal_cardiomyocyte_apopto1.44601772
50* MP0005319_abnormal_enzyme/_coenzyme1.43746307
51MP0004233_abnormal_muscle_weight1.40770454
52MP0002332_abnormal_exercise_endurance1.40575884
53MP0003195_calcinosis1.38318093
54MP0003828_pulmonary_edema1.31921136
55MP0001666_abnormal_nutrient_absorption1.30800375
56* MP0005369_muscle_phenotype1.29440052
57MP0005334_abnormal_fat_pad1.28363132
58MP0005584_abnormal_enzyme/coenzyme_acti1.23330124
59MP0003690_abnormal_glial_cell1.22304515
60MP0009780_abnormal_chondrocyte_physiolo1.21067471
61MP0009115_abnormal_fat_cell1.18054612
62MP0004484_altered_response_of1.16472806
63MP0005266_abnormal_metabolism1.11493570
64MP0005535_abnormal_body_temperature1.10871320
65* MP0002078_abnormal_glucose_homeostasis1.09067674
66MP0005451_abnormal_body_composition1.06373178
67MP0004085_abnormal_heartbeat1.01034728
68MP0010368_abnormal_lymphatic_system1.00835398
69MP0008438_abnormal_cutaneous_collagen1.00123126
70MP0005167_abnormal_blood-brain_barrier0.98154883
71MP0006035_abnormal_mitochondrial_morpho0.98047764
72MP0000003_abnormal_adipose_tissue0.96077882
73MP0003879_abnormal_hair_cell0.94725333
74* MP0002970_abnormal_white_adipose0.93799723
75MP0005595_abnormal_vascular_smooth0.93143083
76MP0004019_abnormal_vitamin_homeostasis0.90577232
77MP0003724_increased_susceptibility_to0.88851173
78MP0000343_altered_response_to0.87132923
79MP0002127_abnormal_cardiovascular_syste0.86673077
80MP0005275_abnormal_skin_tensile0.83590576
81* MP0003953_abnormal_hormone_level0.83201507
82MP0005503_abnormal_tendon_morphology0.82585593
83MP0002909_abnormal_adrenal_gland0.82552483
84MP0000013_abnormal_adipose_tissue0.82222170
85MP0009643_abnormal_urine_homeostasis0.81410792
86MP0001501_abnormal_sleep_pattern0.80823684
87MP0003950_abnormal_plasma_membrane0.79287145
88MP0004272_abnormal_basement_membrane0.76530991
89MP0001764_abnormal_homeostasis0.76395302
90MP0003186_abnormal_redox_activity0.75627841
91MP0002108_abnormal_muscle_morphology0.72494978
92MP0003656_abnormal_erythrocyte_physiolo0.72014407
93MP0001661_extended_life_span0.71757960
94MP0000598_abnormal_liver_morphology0.70699128
95MP0003567_abnormal_fetal_cardiomyocyte0.69962357
96* MP0000266_abnormal_heart_morphology0.68705324
97MP0000249_abnormal_blood_vessel0.68294303
98* MP0003948_abnormal_gas_homeostasis0.67415739
99MP0002254_reproductive_system_inflammat0.65990536
100* MP0005448_abnormal_energy_balance0.65862621
101MP0005376_homeostasis/metabolism_phenot0.65530613
102MP0005165_increased_susceptibility_to0.65516563
103MP0004510_myositis0.64325251
104MP0002295_abnormal_pulmonary_circulatio0.63980101
105MP0000230_abnormal_systemic_arterial0.63644706
106MP0002796_impaired_skin_barrier0.62931792
107MP0005647_abnormal_sex_gland0.60732792
108MP0003045_fibrosis0.60599849
109MP0003566_abnormal_cell_adhesion0.60512732
110MP0004043_abnormal_pH_regulation0.59140800
111MP0003279_aneurysm0.58657013
112* MP0005452_abnormal_adipose_tissue0.58216014
113MP0005164_abnormal_response_to0.58022701
114MP0003959_abnormal_lean_body0.56202885
115MP0008961_abnormal_basal_metabolism0.55055735
116MP0002128_abnormal_blood_circulation0.53881944
117MP0009763_increased_sensitivity_to0.53583760
118* MP0009642_abnormal_blood_homeostasis0.52335936
119MP0002138_abnormal_hepatobiliary_system0.49146571
120MP0003868_abnormal_feces_composition0.47948285
121MP0000579_abnormal_nail_morphology0.46929508

Predicted human phenotypes

RankGene SetZ-score
1Myoglobinuria (HP:0002913)5.35260208
2Exercise-induced myalgia (HP:0003738)5.17238504
3Sudden death (HP:0001699)5.07007272
4Hyperglycinuria (HP:0003108)4.57025034
5Hypoglycemic coma (HP:0001325)4.52940479
6Ventricular tachycardia (HP:0004756)4.27465390
7Rhabdomyolysis (HP:0003201)4.27110811
8Exercise-induced muscle cramps (HP:0003710)4.21171768
9Muscle fiber splitting (HP:0003555)4.18520109
10Ketoacidosis (HP:0001993)4.17981289
11Ketosis (HP:0001946)4.17967741
12Abnormality of fatty-acid metabolism (HP:0004359)4.16653778
13Hyperammonemia (HP:0001987)4.06149119
14Calf muscle hypertrophy (HP:0008981)4.02681979
15Abnormality of complement system (HP:0005339)4.01108391
16Abnormality of glycine metabolism (HP:0010895)3.96306600
17Abnormality of serine family amino acid metabolism (HP:0010894)3.96306600
18Hyporeflexia of lower limbs (HP:0002600)3.90283708
19Muscle hypertrophy of the lower extremities (HP:0008968)3.81388999
20Right ventricular cardiomyopathy (HP:0011663)3.68337966
21Dicarboxylic aciduria (HP:0003215)3.63167900
22Abnormality of dicarboxylic acid metabolism (HP:0010995)3.63167900
23Nemaline bodies (HP:0003798)3.60970064
24Increased connective tissue (HP:0009025)3.60538369
25Lipoatrophy (HP:0100578)3.53077909
26Hyperglycinemia (HP:0002154)3.45041820
27Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.44543772
28Xanthomatosis (HP:0000991)3.44273472
29Deep venous thrombosis (HP:0002625)3.43940775
30Difficulty running (HP:0009046)3.41292691
31Hypoalphalipoproteinemia (HP:0003233)3.38982209
32Abnormality of skeletal muscle fiber size (HP:0012084)3.37834802
33Intrahepatic cholestasis (HP:0001406)3.31381710
34Palpitations (HP:0001962)3.21105177
35Asymmetric septal hypertrophy (HP:0001670)3.20709756
36Atrial fibrillation (HP:0005110)3.12950491
37Abnormality of aromatic amino acid family metabolism (HP:0004338)3.12761926
38Hyperlipoproteinemia (HP:0010980)3.12406710
39Abnormality of the calf musculature (HP:0001430)3.07204033
40Dilated cardiomyopathy (HP:0001644)2.99840179
41Hypolipoproteinemia (HP:0010981)2.99355600
42Subaortic stenosis (HP:0001682)2.90711160
43Abnormality of the left ventricular outflow tract (HP:0011103)2.90711160
44Atrioventricular block (HP:0001678)2.89396083
45Primary atrial arrhythmia (HP:0001692)2.87242003
46Increased muscle lipid content (HP:0009058)2.85157035
47Joint hemorrhage (HP:0005261)2.81546473
48Hemorrhage of the eye (HP:0011885)2.80614972
49Pigmentary retinal degeneration (HP:0001146)2.80390880
50Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.79996238
51Hypobetalipoproteinemia (HP:0003563)2.79367490
52Systemic lupus erythematosus (HP:0002725)2.79333098
53EMG: myopathic abnormalities (HP:0003458)2.76470249
54Hepatic necrosis (HP:0002605)2.76265973
55Supraventricular tachycardia (HP:0004755)2.75386709
56Cerebral edema (HP:0002181)2.75188896
57Muscle stiffness (HP:0003552)2.74582995
58Frequent falls (HP:0002359)2.71958180
59Supraventricular arrhythmia (HP:0005115)2.71753151
60Abnormality of alanine metabolism (HP:0010916)2.71563748
61Hyperalaninemia (HP:0003348)2.71563748
62Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.71563748
63Bundle branch block (HP:0011710)2.70115688
64Glomerulonephritis (HP:0000099)2.69627418
65Abnormality of monocarboxylic acid metabolism (HP:0010996)2.68538842
66Insulin resistance (HP:0000855)2.63799227
67Syncope (HP:0001279)2.63372206
68Epidermoid cyst (HP:0200040)2.62703022
69Facial shape deformation (HP:0011334)2.62159216
70Potter facies (HP:0002009)2.62159216
71Heart block (HP:0012722)2.60719144
72Complement deficiency (HP:0004431)2.60460261
73Rimmed vacuoles (HP:0003805)2.59239880
74Ventricular arrhythmia (HP:0004308)2.53676040
75Myotonia (HP:0002486)2.52444010
76Generalized aminoaciduria (HP:0002909)2.52275432
77Type 1 muscle fiber predominance (HP:0003803)2.51115578
78Lethargy (HP:0001254)2.51013289
79Metabolic acidosis (HP:0001942)2.47754130
80Hyperinsulinemic hypoglycemia (HP:0000825)2.43754546
81Abnormal atrioventricular conduction (HP:0005150)2.43590424
82Abnormality of serum amino acid levels (HP:0003112)2.39950914
83Prolonged partial thromboplastin time (HP:0003645)2.38615736
84Muscle fiber inclusion bodies (HP:0100299)2.37343040
85Abnormality of glutamine family amino acid metabolism (HP:0010902)2.33822539
86Skin nodule (HP:0200036)2.33152719
87Cholelithiasis (HP:0001081)2.32542216
88Hyperglycemia (HP:0003074)2.30615582
89Gowers sign (HP:0003391)2.28840687
90Generalized muscle weakness (HP:0003324)2.26850805
91Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.26584558
92Difficulty climbing stairs (HP:0003551)2.21574686
93Nausea (HP:0002018)2.19021866
94Abnormal gallbladder morphology (HP:0012437)2.18795243
95Nephritis (HP:0000123)2.18180428
96Oligomenorrhea (HP:0000876)2.16871747
97EMG: neuropathic changes (HP:0003445)2.16313593
98Infantile muscular hypotonia (HP:0008947)2.14591938
99Increased serum pyruvate (HP:0003542)2.12152629
100Prolonged QT interval (HP:0001657)2.11482502
101Lymphangioma (HP:0100764)2.07192847
102Abnormality of aspartate family amino acid metabolism (HP:0010899)2.06864385
103Acute encephalopathy (HP:0006846)2.06547597
104Vomiting (HP:0002013)2.06272830
105Conjunctival hamartoma (HP:0100780)2.05558545
106Hyperkalemia (HP:0002153)2.05387648
107Distal lower limb muscle weakness (HP:0009053)2.02819033
108Ragged-red muscle fibers (HP:0003200)2.02693305
109Hypertriglyceridemia (HP:0002155)1.99827072
110Polycythemia (HP:0001901)1.99102687
111Abnormality of purine metabolism (HP:0004352)1.98264345
112Abnormality of proline metabolism (HP:0010907)1.98224093
113Hydroxyprolinuria (HP:0003080)1.98224093
114Hypercholesterolemia (HP:0003124)1.97545406
115Increased variability in muscle fiber diameter (HP:0003557)1.97414251
116Pancreatic islet-cell hyperplasia (HP:0004510)1.96807803
117Insulin-resistant diabetes mellitus (HP:0000831)1.96642145
118Testicular atrophy (HP:0000029)1.96540321
119Renal cortical cysts (HP:0000803)1.95274681
120Lactic acidosis (HP:0003128)1.94140031
121Myocardial infarction (HP:0001658)1.93876662
122Decreased circulating renin level (HP:0003351)1.93429537
123Prominent supraorbital ridges (HP:0000336)1.92612765
124Hypoglycemic seizures (HP:0002173)1.91391711
125Delayed CNS myelination (HP:0002188)1.90849051
126Neck muscle weakness (HP:0000467)1.90319258
127Gout (HP:0001997)1.89581819
128Acanthosis nigricans (HP:0000956)1.89206517
129Scapular winging (HP:0003691)1.87833846

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK4.91486536
2TTN3.97813108
3TRIB33.82030324
4OBSCN3.58004166
5PDK43.47698649
6PDK33.47698649
7PHKG13.21587469
8PHKG23.21587469
9SIK12.84570547
10PKN22.78793281
11PINK12.62648283
12FRK2.53299757
13CAMK1D2.51868167
14EPHA32.36147491
15LMTK22.24454781
16PDK22.12651385
17CAMK11.95700892
18ICK1.95249359
19MYLK1.73415822
20TIE11.73238441
21CAMK1G1.68802644
22NLK1.63944162
23INSRR1.62948947
24NEK11.60786113
25DMPK1.58192732
26ERN11.56421251
27PIK3CA1.46177819
28FGFR41.43614592
29RIPK11.36929700
30MAP3K61.32320917
31PDGFRA1.25396469
32AKT31.22529863
33MAP3K71.20286923
34LATS11.19910370
35FLT31.18282924
36* PRKAA21.13791039
37SGK21.11845892
38MAP2K31.11247197
39EPHB21.09332218
40MAPK111.06855110
41* PRKAA11.03492545
42EEF2K1.00128393
43MAPK120.96488144
44DDR20.96048354
45PRKD10.94019718
46STK38L0.92656512
47MAP3K110.89918932
48MARK10.88881710
49PIK3CG0.87805291
50MUSK0.86616374
51FER0.83419419
52MAPK70.82361276
53GRK10.81518498
54DAPK20.81367285
55CAMKK20.81238651
56PRKG10.80538653
57MAPKAPK30.78917854
58SGK4940.78057260
59SGK2230.78057260
60KDR0.77963312
61TGFBR20.75240575
62LATS20.74955711
63MAP3K30.73487225
64ADRBK10.73330475
65STK110.72650751
66MAPK150.72464389
67TRPM70.71127400
68MTOR0.70341023
69PTK60.67208034
70NTRK30.64017577
71EPHB10.61054199
72CAMK2D0.60594680
73STK240.60267388
74IGF1R0.59766584
75NEK90.59718383
76MAP2K40.57895667
77WNK40.57730172
78KIT0.57290620
79MARK20.56984060
80MST1R0.55837011
81PAK30.55652662
82PDPK10.55508557
83CSK0.55298782
84CDC42BPA0.55255823
85STK380.54410842
86MAP2K60.53771833
87MAPK30.53613369
88DYRK1B0.53424629
89GSK3A0.53320354
90* PRKACG0.52541750
91JAK20.52358356
92RPS6KC10.52317883
93RPS6KL10.52317883
94BMX0.52189848
95ILK0.51726852
96ACVR1B0.50067410
97PRKD20.49918143
98CDK60.48985141
99MAP3K50.48635930
100PRKCE0.47081935
101IRAK10.46654156
102MAP3K100.46460337
103JAK10.45903438
104WNK10.45369145
105STK390.44778767
106RPS6KA60.43735967
107OXSR10.43509031
108ADRBK20.43053718
109WNK30.42836498
110TYRO30.41439234
111CAMK40.41300272
112BMPR1B0.40756921
113CAMK2G0.40553967
114PDK10.38700483
115MAPK40.36718515
116AKT20.35942957
117PKN10.35187300
118RPS6KA10.34810102
119FGFR30.34386868
120GRK70.33808702
121ROCK10.33688270
122STK40.33074053
123ERBB40.32539011
124PRKACB0.30703112
125TYK20.30311591
126SGK30.29814485
127PRKACA0.28441431
128CDK40.27195202
129PDGFRB0.26889313
130FGFR20.25713368
131MET0.24956252
132ABL20.24394468
133RET0.23455889
134MAP2K10.21493379
135RPS6KA30.20521786

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.94744333
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.65531440
3Fatty acid degradation_Homo sapiens_hsa000713.63324193
4* Propanoate metabolism_Homo sapiens_hsa006403.59979456
5Fatty acid metabolism_Homo sapiens_hsa012123.35045812
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.33251287
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.30819833
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.78483576
9PPAR signaling pathway_Homo sapiens_hsa033202.57552043
10Primary bile acid biosynthesis_Homo sapiens_hsa001202.53579308
11Arginine biosynthesis_Homo sapiens_hsa002202.34659504
12Carbon metabolism_Homo sapiens_hsa012002.28856148
13Nitrogen metabolism_Homo sapiens_hsa009102.25604911
14Tryptophan metabolism_Homo sapiens_hsa003802.24508004
15Butanoate metabolism_Homo sapiens_hsa006502.23314621
16Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.21931273
17* Pyruvate metabolism_Homo sapiens_hsa006202.04775536
18Fatty acid elongation_Homo sapiens_hsa000621.92527711
19* Fatty acid biosynthesis_Homo sapiens_hsa000611.89731573
20Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.86306287
21beta-Alanine metabolism_Homo sapiens_hsa004101.78917244
22Peroxisome_Homo sapiens_hsa041461.78190469
23Biosynthesis of amino acids_Homo sapiens_hsa012301.55153348
24Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.53646263
25Starch and sucrose metabolism_Homo sapiens_hsa005001.43082322
26Caffeine metabolism_Homo sapiens_hsa002321.38706105
27Pentose and glucuronate interconversions_Homo sapiens_hsa000401.38061731
28Complement and coagulation cascades_Homo sapiens_hsa046101.35918010
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.34226954
30Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.25416993
31Phenylalanine metabolism_Homo sapiens_hsa003601.23575905
32Fat digestion and absorption_Homo sapiens_hsa049751.22035723
33Lysine degradation_Homo sapiens_hsa003101.19460095
34Cardiac muscle contraction_Homo sapiens_hsa042601.14797149
35Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.12382945
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.11458679
37Glycerolipid metabolism_Homo sapiens_hsa005611.10475345
38Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.10055372
39Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.01532670
40Dilated cardiomyopathy_Homo sapiens_hsa054141.00745176
41Tyrosine metabolism_Homo sapiens_hsa003501.00474317
42Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.00451757
43Arginine and proline metabolism_Homo sapiens_hsa003301.00334738
44Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.93856804
45Bile secretion_Homo sapiens_hsa049760.93600521
46Chemical carcinogenesis_Homo sapiens_hsa052040.93229457
47Renin secretion_Homo sapiens_hsa049240.92788724
48Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.88977923
49Histidine metabolism_Homo sapiens_hsa003400.85732071
50Vascular smooth muscle contraction_Homo sapiens_hsa042700.85348448
51Cysteine and methionine metabolism_Homo sapiens_hsa002700.84592266
52ABC transporters_Homo sapiens_hsa020100.84511484
53* Adipocytokine signaling pathway_Homo sapiens_hsa049200.84079842
54* Insulin resistance_Homo sapiens_hsa049310.81748489
55Staphylococcus aureus infection_Homo sapiens_hsa051500.81107383
56Drug metabolism - other enzymes_Homo sapiens_hsa009830.79814049
57Retinol metabolism_Homo sapiens_hsa008300.79368852
58Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.78867480
59Selenocompound metabolism_Homo sapiens_hsa004500.78667941
60* AMPK signaling pathway_Homo sapiens_hsa041520.75986324
61Parkinsons disease_Homo sapiens_hsa050120.75012925
62Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.73501646
63Aldosterone synthesis and secretion_Homo sapiens_hsa049250.71245740
64* Glucagon signaling pathway_Homo sapiens_hsa049220.70404428
65Steroid hormone biosynthesis_Homo sapiens_hsa001400.69921118
66Oxidative phosphorylation_Homo sapiens_hsa001900.68444045
67Arachidonic acid metabolism_Homo sapiens_hsa005900.65476370
68* Insulin signaling pathway_Homo sapiens_hsa049100.63930247
69Sulfur relay system_Homo sapiens_hsa041220.62373714
70Galactose metabolism_Homo sapiens_hsa000520.62284451
71Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.62027013
72Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.59799000
73Pentose phosphate pathway_Homo sapiens_hsa000300.59154495
74Fructose and mannose metabolism_Homo sapiens_hsa000510.58868290
75Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.58010313
76Sulfur metabolism_Homo sapiens_hsa009200.57121721
77ECM-receptor interaction_Homo sapiens_hsa045120.56334633
78Folate biosynthesis_Homo sapiens_hsa007900.53162652
79Alzheimers disease_Homo sapiens_hsa050100.48958950
80* Metabolic pathways_Homo sapiens_hsa011000.43154963
81Vitamin B6 metabolism_Homo sapiens_hsa007500.41353406
82Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.40569835
83Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.37509964
84Viral myocarditis_Homo sapiens_hsa054160.36857570
85Longevity regulating pathway - mammal_Homo sapiens_hsa042110.36611398
86Renin-angiotensin system_Homo sapiens_hsa046140.34646519
87Glutathione metabolism_Homo sapiens_hsa004800.34041608
88Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.34003614
89Protein digestion and absorption_Homo sapiens_hsa049740.31275585
90Huntingtons disease_Homo sapiens_hsa050160.30184943
91Calcium signaling pathway_Homo sapiens_hsa040200.29338153
92cAMP signaling pathway_Homo sapiens_hsa040240.28960660
93Insulin secretion_Homo sapiens_hsa049110.28381959
94Central carbon metabolism in cancer_Homo sapiens_hsa052300.27856459
95Oxytocin signaling pathway_Homo sapiens_hsa049210.27801871
96Glycerophospholipid metabolism_Homo sapiens_hsa005640.27705990
97alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.26420658
98Circadian rhythm_Homo sapiens_hsa047100.24506939
99Maturity onset diabetes of the young_Homo sapiens_hsa049500.23498509
100Mineral absorption_Homo sapiens_hsa049780.23023292
101Cyanoamino acid metabolism_Homo sapiens_hsa004600.22930356
102Vitamin digestion and absorption_Homo sapiens_hsa049770.22228348
103Morphine addiction_Homo sapiens_hsa050320.20931248
104Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.18496262
105Gastric acid secretion_Homo sapiens_hsa049710.16036467
106Steroid biosynthesis_Homo sapiens_hsa001000.15921552
107Dorso-ventral axis formation_Homo sapiens_hsa043200.15004650
108Pancreatic secretion_Homo sapiens_hsa049720.13891013
109Circadian entrainment_Homo sapiens_hsa047130.13593975
110FoxO signaling pathway_Homo sapiens_hsa040680.13514490
111Salivary secretion_Homo sapiens_hsa049700.12952981
112mTOR signaling pathway_Homo sapiens_hsa041500.10967938
113Type II diabetes mellitus_Homo sapiens_hsa049300.10661154
114Linoleic acid metabolism_Homo sapiens_hsa005910.07555710
115HIF-1 signaling pathway_Homo sapiens_hsa040660.06182623
116Focal adhesion_Homo sapiens_hsa045100.03160075
117cGMP-PKG signaling pathway_Homo sapiens_hsa040220.01029563
118Adherens junction_Homo sapiens_hsa045200.00662014
119Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0172501

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