ACAD10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the acyl-CoA dehydrogenase family of enzymes (ACADs), which participate in the beta-oxidation of fatty acids in mitochondria. The encoded enzyme contains a hydrolase domain at the N-terminal portion, a serine/threonine protein kinase catlytic domain in the central region, and a conserved ACAD domain at the C-terminus. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)7.16076286
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.16076286
3L-phenylalanine metabolic process (GO:0006558)6.83676386
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.83676386
5aromatic amino acid family catabolic process (GO:0009074)6.72935564
6indole-containing compound catabolic process (GO:0042436)6.34428578
7indolalkylamine catabolic process (GO:0046218)6.34428578
8tryptophan catabolic process (GO:0006569)6.34428578
9tryptophan metabolic process (GO:0006568)5.93532433
10kynurenine metabolic process (GO:0070189)5.92767232
11glyoxylate metabolic process (GO:0046487)5.81657903
12triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.75170222
13bile acid biosynthetic process (GO:0006699)5.55993495
14cysteine metabolic process (GO:0006534)5.42767714
15sulfur amino acid catabolic process (GO:0000098)5.21176669
16alpha-linolenic acid metabolic process (GO:0036109)5.18562859
17serine family amino acid catabolic process (GO:0009071)5.15509899
18fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.12237832
19urea cycle (GO:0000050)5.07034844
20urea metabolic process (GO:0019627)5.07034844
21lysine metabolic process (GO:0006553)5.05370966
22lysine catabolic process (GO:0006554)5.05370966
23high-density lipoprotein particle remodeling (GO:0034375)5.02526504
24homocysteine metabolic process (GO:0050667)4.91960240
25aromatic amino acid family metabolic process (GO:0009072)4.90950650
26amino-acid betaine metabolic process (GO:0006577)4.90479870
27protein carboxylation (GO:0018214)4.76986497
28peptidyl-glutamic acid carboxylation (GO:0017187)4.76986497
29bile acid metabolic process (GO:0008206)4.76818412
30nitrogen cycle metabolic process (GO:0071941)4.72120184
31regulation of fibrinolysis (GO:0051917)4.70164027
32negative regulation of fibrinolysis (GO:0051918)4.68744506
33epoxygenase P450 pathway (GO:0019373)4.66395372
34alpha-amino acid catabolic process (GO:1901606)4.64209490
35tyrosine metabolic process (GO:0006570)4.61722599
36complement activation, alternative pathway (GO:0006957)4.60853813
37amine catabolic process (GO:0009310)4.55941224
38cellular biogenic amine catabolic process (GO:0042402)4.55941224
39regulation of protein activation cascade (GO:2000257)4.53741157
40indolalkylamine metabolic process (GO:0006586)4.52499908
41regulation of triglyceride catabolic process (GO:0010896)4.47528714
42cellular ketone body metabolic process (GO:0046950)4.44200664
43short-chain fatty acid metabolic process (GO:0046459)4.42534246
44reverse cholesterol transport (GO:0043691)4.39912293
45regulation of cholesterol esterification (GO:0010872)4.36827649
46drug transmembrane transport (GO:0006855)4.34626485
47cellular amino acid catabolic process (GO:0009063)4.34224476
48triglyceride homeostasis (GO:0070328)4.33434705
49acylglycerol homeostasis (GO:0055090)4.33434705
50protein-lipid complex remodeling (GO:0034368)4.28596918
51macromolecular complex remodeling (GO:0034367)4.28596918
52plasma lipoprotein particle remodeling (GO:0034369)4.28596918
53negative regulation of sterol transport (GO:0032372)4.24971546
54negative regulation of cholesterol transport (GO:0032375)4.24971546
55cellular glucuronidation (GO:0052695)4.24022588
56regulation of complement activation (GO:0030449)4.22359488
57urate metabolic process (GO:0046415)4.20707111
58drug catabolic process (GO:0042737)4.18827130
59serine family amino acid metabolic process (GO:0009069)4.16470586
60phospholipid efflux (GO:0033700)4.14670507
61cellular modified amino acid catabolic process (GO:0042219)4.14327449
62coenzyme catabolic process (GO:0009109)4.14076866
63benzene-containing compound metabolic process (GO:0042537)4.09825027
64ethanol oxidation (GO:0006069)4.09389746
65glutamate metabolic process (GO:0006536)4.03792046
66glycine metabolic process (GO:0006544)4.02824277
67plasma lipoprotein particle clearance (GO:0034381)4.01958404
68bile acid and bile salt transport (GO:0015721)4.01786135
69acetyl-CoA metabolic process (GO:0006084)3.96938734
70carboxylic acid catabolic process (GO:0046395)3.94409398
71organic acid catabolic process (GO:0016054)3.94409398
72oxidative demethylation (GO:0070989)3.93844258
73alkaloid metabolic process (GO:0009820)3.92925726
74imidazole-containing compound metabolic process (GO:0052803)3.92555155
75fatty acid beta-oxidation (GO:0006635)3.91634967
76aldehyde catabolic process (GO:0046185)3.89059096
77serine family amino acid biosynthetic process (GO:0009070)3.87166396
78uronic acid metabolic process (GO:0006063)3.86507021
79glucuronate metabolic process (GO:0019585)3.86507021
80ketone body metabolic process (GO:1902224)3.85991420
81fatty acid oxidation (GO:0019395)3.85986872
82valine metabolic process (GO:0006573)3.84452671
83carnitine metabolic process (GO:0009437)3.79605399
84cholesterol efflux (GO:0033344)3.79571772
85lipid oxidation (GO:0034440)3.79082460
86arginine metabolic process (GO:0006525)3.78463601
87monocarboxylic acid catabolic process (GO:0072329)3.75127283
88mannose metabolic process (GO:0006013)3.70763222
89fatty acid catabolic process (GO:0009062)3.68377855
90branched-chain amino acid catabolic process (GO:0009083)3.68184347
912-oxoglutarate metabolic process (GO:0006103)3.65875819
92drug transport (GO:0015893)3.64795629
93NAD biosynthetic process (GO:0009435)3.63510322
94low-density lipoprotein particle remodeling (GO:0034374)3.63497385
95dicarboxylic acid biosynthetic process (GO:0043650)3.63349181
96aspartate family amino acid catabolic process (GO:0009068)3.63250558
97regulation of bile acid biosynthetic process (GO:0070857)3.61691432
98nicotinamide nucleotide biosynthetic process (GO:0019359)3.61061018
99pyridine nucleotide biosynthetic process (GO:0019363)3.61061018
100S-adenosylmethionine metabolic process (GO:0046500)3.60719736
101exogenous drug catabolic process (GO:0042738)3.59930200
102negative regulation of lipase activity (GO:0060192)3.59907634
103plasma lipoprotein particle assembly (GO:0034377)3.59074521
104fibrinolysis (GO:0042730)3.57940378
105branched-chain amino acid metabolic process (GO:0009081)3.56016227
106amino-acid betaine transport (GO:0015838)3.49680462
107carnitine transport (GO:0015879)3.49680462
108drug metabolic process (GO:0017144)3.40481052
109carnitine transmembrane transport (GO:1902603)3.34616642
110quaternary ammonium group transport (GO:0015697)3.27000543
111L-methionine salvage (GO:0071267)3.26115554
112L-methionine biosynthetic process (GO:0071265)3.26115554
113amino acid salvage (GO:0043102)3.26115554
114omega-hydroxylase P450 pathway (GO:0097267)3.25157556
115fatty acid transmembrane transport (GO:1902001)3.17911990
116positive regulation of triglyceride lipase activity (GO:0061365)3.14148042
117positive regulation of lipoprotein lipase activity (GO:0051006)3.14148042
118carnitine shuttle (GO:0006853)3.06594858
119ethanol metabolic process (GO:0006067)3.05583280
120phosphatidylglycerol biosynthetic process (GO:0006655)2.89047831
121dicarboxylic acid catabolic process (GO:0043649)2.77108472
122histone H3-K4 trimethylation (GO:0080182)2.75396170
123positive regulation of icosanoid secretion (GO:0032305)2.71202807
124pyrimidine nucleobase catabolic process (GO:0006208)2.69562993
125positive regulation of fatty acid biosynthetic process (GO:0045723)2.68965821
126L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.68952193
127fat-soluble vitamin biosynthetic process (GO:0042362)2.68370309
128positive regulation of B cell differentiation (GO:0045579)2.63279037
129flavonoid metabolic process (GO:0009812)2.63170680
130arginine catabolic process (GO:0006527)2.61767433
131quinone biosynthetic process (GO:1901663)2.60626331
132phenylpropanoid metabolic process (GO:0009698)2.59170765
133methionine biosynthetic process (GO:0009086)2.57640926
134plasma lipoprotein particle organization (GO:0071827)2.54587621
135positive regulation of fatty acid metabolic process (GO:0045923)2.53019068
136autophagic vacuole fusion (GO:0000046)2.52791122
137phospholipid homeostasis (GO:0055091)2.51217737
138positive regulation of fatty acid transport (GO:2000193)2.51138105
139histone H4-K12 acetylation (GO:0043983)2.50832959
140regulation of triglyceride metabolic process (GO:0090207)2.49690683
141mannosylation (GO:0097502)2.49029000
142sulfur amino acid biosynthetic process (GO:0000097)2.48234714
143positive regulation of fatty acid oxidation (GO:0046321)2.46165961
144proline metabolic process (GO:0006560)2.45538766

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse7.93522671
2EGR1_23403033_ChIP-Seq_LIVER_Mouse6.77826761
3PPARA_22158963_ChIP-Seq_LIVER_Mouse6.73020780
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.17662523
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.16387624
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.93483581
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.71151374
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.80493168
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.76229289
10ELF1_17652178_ChIP-ChIP_JURKAT_Human3.32770883
11CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.60918415
12ZNF274_21170338_ChIP-Seq_K562_Hela2.29066001
13BP1_19119308_ChIP-ChIP_Hs578T_Human2.18765816
14VDR_21846776_ChIP-Seq_THP-1_Human2.14851789
15DROSHA_22980978_ChIP-Seq_HELA_Human2.14082863
16TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.12077333
17ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.9084256
18TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.99348773
19SCL_19346495_ChIP-Seq_HPC-7_Human1.94499359
20VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.93262029
21* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.89144068
22RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.82098877
23E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.79135709
24E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.77478360
25RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.72248173
26BCL6_27268052_Chip-Seq_Bcells_Human1.70456302
27E2F1_20622854_ChIP-Seq_HELA_Human1.69193503
28P68_20966046_ChIP-Seq_HELA_Human1.68155437
29BCOR_27268052_Chip-Seq_Bcells_Human1.63851550
30CIITA_25753668_ChIP-Seq_RAJI_Human1.59000957
31CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.57755693
32SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.54965733
33STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.51390440
34FOXA2_19822575_ChIP-Seq_HepG2_Human1.50504634
35YY1_22570637_ChIP-Seq_MALME-3M_Human1.49513982
36ELF1_20517297_ChIP-Seq_JURKAT_Human1.47104467
37LXR_22292898_ChIP-Seq_THP-1_Human1.46350842
38HTT_18923047_ChIP-ChIP_STHdh_Human1.44911873
39PHF8_20622854_ChIP-Seq_HELA_Human1.44397393
40CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.43987907
41LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.42258923
42GATA1_19941827_ChIP-Seq_MEL_Mouse1.40811819
43ERA_21632823_ChIP-Seq_H3396_Human1.40571855
44IGF1R_20145208_ChIP-Seq_DFB_Human1.37589299
45HNF4A_19822575_ChIP-Seq_HepG2_Human1.36765046
46* P300_27268052_Chip-Seq_Bcells_Human1.33338705
47LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.32966880
48IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.32898859
49VDR_24763502_ChIP-Seq_THP-1_Human1.30227766
50SMC4_20622854_ChIP-Seq_HELA_Human1.28522942
51RAC3_21632823_ChIP-Seq_H3396_Human1.28434925
52MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.27615778
53GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24426305
54IRF8_21731497_ChIP-ChIP_J774_Mouse1.23581327
55EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.22690090
56GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.20111349
57UTX_26944678_Chip-Seq_JUKART_Human1.20024061
58TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19920615
59SRF_21415370_ChIP-Seq_HL-1_Mouse1.19137972
60CLOCK_20551151_ChIP-Seq_293T_Human1.18502426
61IRF8_22096565_ChIP-ChIP_GC-B_Human1.17900042
62GATA1_19941826_ChIP-Seq_K562_Human1.17088202
63EZH2_22144423_ChIP-Seq_EOC_Human1.16603748
64WDR5_24793694_ChIP-Seq_LNCAP_Human1.16578817
65OCT4_20526341_ChIP-Seq_ESCs_Human1.16362342
66CTCF_21964334_ChIP-Seq_BJAB-B_Human1.15297674
67STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.14859383
68MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.13535066
69RXRA_24833708_ChIP-Seq_LIVER_Mouse1.13252938
70RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.12930288
71SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.12514412
72GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.11358615
73HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.10317654
74TET1_21451524_ChIP-Seq_MESCs_Mouse1.06940416
75ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.05957525
76OCT4_19829295_ChIP-Seq_ESCs_Human1.04546634
77MYC_22102868_ChIP-Seq_BL_Human1.03881294
78PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.02950408
79ZNF263_19887448_ChIP-Seq_K562_Human1.02865705
80PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.01283449
81STAT1_20625510_ChIP-Seq_HELA_Human1.00669850
82FOXH1_21741376_ChIP-Seq_ESCs_Human1.00596807
83SPI1_23127762_ChIP-Seq_K562_Human0.98786531
84ETV2_25802403_ChIP-Seq_MESCs_Mouse0.98680550
85KAP1_22055183_ChIP-Seq_ESCs_Mouse0.97879512
86SPI1_20517297_ChIP-Seq_HL60_Human0.96447764
87CTCF_27219007_Chip-Seq_Bcells_Human0.96114777
88SA1_27219007_Chip-Seq_Bcells_Human0.94335668
89CTCF_26484167_Chip-Seq_Bcells_Mouse0.94028144
90KDM2B_26808549_Chip-Seq_SUP-B15_Human0.93821047
91MAF_26560356_Chip-Seq_TH2_Human0.93204245
92TP63_22573176_ChIP-Seq_HFKS_Human0.91537513
93SOX2_27498859_Chip-Seq_STOMACH_Mouse0.91092423
94SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90209106
95Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.90047685
96IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.89931839
97THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.88889816
98* GATA4_25053715_ChIP-Seq_YYC3_Human0.88144241
99ESR1_21235772_ChIP-Seq_MCF-7_Human0.86402026
100TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.85860678
101AUTS2_25519132_ChIP-Seq_293T-REX_Human0.83050559
102GATA1_22025678_ChIP-Seq_K562_Human0.79388404
103TAF15_26573619_Chip-Seq_HEK293_Human0.78585299
104STAT1_17558387_ChIP-Seq_HELA_Human0.77327863
105ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.76649944
106RARG_19884340_ChIP-ChIP_MEFs_Mouse0.76499151
107BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.74458170
108AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.73828901
109NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.72809234
110NRF2_20460467_ChIP-Seq_MEFs_Mouse0.72809234
111* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.72235462
112* ESR2_21235772_ChIP-Seq_MCF-7_Human0.72202753
113CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.72163829
114RAD21_21589869_ChIP-Seq_MESCs_Mouse0.71916699
115RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.69726264
116GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.68633767
117AR_20517297_ChIP-Seq_VCAP_Human0.67776132
118SUZ12_27294783_Chip-Seq_NPCs_Mouse0.67770819
119SALL4_18804426_ChIP-ChIP_XEN_Mouse0.67290985
120SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.67272344
121PIAS1_25552417_ChIP-Seq_VCAP_Human0.67232996
122* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.67125247
123EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.66748833
124EZH2_27294783_Chip-Seq_NPCs_Mouse0.66403454
125PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.66147086
126NFE2_27457419_Chip-Seq_LIVER_Mouse0.65607327
127FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.65200912
128CDX2_20551321_ChIP-Seq_CACO-2_Human0.65139219
129RARA_24833708_ChIP-Seq_LIVER_Mouse0.64495629
130EGR1_19032775_ChIP-ChIP_M12_Human0.62833317
131CRX_20693478_ChIP-Seq_RETINA_Mouse0.62129634
132OCT4_21477851_ChIP-Seq_ESCs_Mouse0.61177100
133STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.61111160
134PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.60703929
135FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.59915006
136BCAT_22108803_ChIP-Seq_LS180_Human0.59890917
137CEBPB_22108803_ChIP-Seq_LS180_Human0.59864157
138ESET_19884257_ChIP-Seq_ESCs_Mouse0.59210308
139ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.58470973
140IRF1_19129219_ChIP-ChIP_H3396_Human0.56753950
141SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.56197583
142RUNX1_27457419_Chip-Seq_LIVER_Mouse0.54834922
143NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.54374743
144PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.54223676
145FOXA1_25552417_ChIP-Seq_VCAP_Human0.54003763
146* CBP_21632823_ChIP-Seq_H3396_Human0.53955413
147MYC_19915707_ChIP-ChIP_AK7_Human0.53313315
148PPAR_26484153_Chip-Seq_NCI-H1993_Human0.52931881
149SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.52697106
150CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.51134335
151ESR1_20079471_ChIP-ChIP_T-47D_Human0.50177381
152RARB_24833708_ChIP-Seq_LIVER_Mouse0.49242224
153AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.48761498
154* CDX2_22108803_ChIP-Seq_LS180_Human0.48404892
155NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.48362540
156PCGF2_27294783_Chip-Seq_NPCs_Mouse0.47671578
157ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.47365653
158ESRRB_18555785_Chip-Seq_ESCs_Mouse0.46438418
159FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.46015039
160GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.45678126
161OCT4_18555785_Chip-Seq_ESCs_Mouse0.44019120
162SMAD1_18555785_Chip-Seq_ESCs_Mouse0.42310461
163EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.41421608
164PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.41283601
165GBX2_23144817_ChIP-Seq_PC3_Human0.40333740
166PU1_27457419_Chip-Seq_LIVER_Mouse0.40227975
167SOX2_22085726_ChIP-Seq_NPCs_Mouse0.40111463
168SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.40052070
169TAF2_19829295_ChIP-Seq_ESCs_Human0.39809699

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.07611348
2MP0005360_urolithiasis7.76450953
3MP0005085_abnormal_gallbladder_physiolo5.97019823
4MP0005365_abnormal_bile_salt5.75940617
5MP0008875_abnormal_xenobiotic_pharmacok4.94322638
6MP0003806_abnormal_nucleotide_metabolis3.83091575
7MP0003252_abnormal_bile_duct3.69176442
8MP0010329_abnormal_lipoprotein_level3.38888088
9MP0005332_abnormal_amino_acid3.25707889
10MP0003195_calcinosis3.10857279
11MP0009840_abnormal_foam_cell2.83594347
12MP0004019_abnormal_vitamin_homeostasis2.77693183
13MP0005083_abnormal_biliary_tract2.62202764
14MP0003172_abnormal_lysosome_physiology2.49916645
15MP0001666_abnormal_nutrient_absorption2.45483468
16MP0002138_abnormal_hepatobiliary_system2.38692949
17MP0003136_yellow_coat_color2.31090133
18MP0002118_abnormal_lipid_homeostasis2.09239325
19MP0000609_abnormal_liver_physiology2.03341503
20MP0003191_abnormal_cellular_cholesterol2.00706668
21MP0005451_abnormal_body_composition1.92998181
22MP0004147_increased_porphyrin_level1.89983023
23MP0009278_abnormal_bone_marrow1.81497690
24MP0001764_abnormal_homeostasis1.81157559
25MP0005670_abnormal_white_adipose1.80823793
26MP0005319_abnormal_enzyme/_coenzyme1.79001452
27MP0003868_abnormal_feces_composition1.71452090
28MP0002653_abnormal_ependyma_morphology1.70668667
29MP0009643_abnormal_urine_homeostasis1.68386836
30MP0005377_hearing/vestibular/ear_phenot1.62223226
31MP0003878_abnormal_ear_physiology1.62223226
32MP0005584_abnormal_enzyme/coenzyme_acti1.61834780
33MP0003183_abnormal_peptide_metabolism1.55899101
34MP0000372_irregular_coat_pigmentation1.54687163
35MP0000015_abnormal_ear_pigmentation1.49976948
36MP0003186_abnormal_redox_activity1.47132156
37MP0009697_abnormal_copulation1.41850443
38MP0005646_abnormal_pituitary_gland1.41839683
39MP0005397_hematopoietic_system_phenotyp1.38595957
40MP0001545_abnormal_hematopoietic_system1.38595957
41MP0000371_diluted_coat_color1.35955042
42MP0001835_abnormal_antigen_presentation1.34717698
43MP0008995_early_reproductive_senescence1.25995278
44MP0002876_abnormal_thyroid_physiology1.24233513
45MP0000569_abnormal_digit_pigmentation1.23940176
46MP0005647_abnormal_sex_gland1.23502810
47MP0009764_decreased_sensitivity_to1.23372109
48MP0000383_abnormal_hair_follicle1.21724933
49MP0005636_abnormal_mineral_homeostasis1.21387990
50MP0003011_delayed_dark_adaptation1.19331473
51MP0001800_abnormal_humoral_immune1.18303791
52MP0001661_extended_life_span1.16602616
53MP0002095_abnormal_skin_pigmentation1.10247179
54MP0000598_abnormal_liver_morphology1.04807475
55MP0005551_abnormal_eye_electrophysiolog1.04219289
56MP0001986_abnormal_taste_sensitivity1.02669568
57MP0005025_abnormal_response_to1.01641877
58MP0004043_abnormal_pH_regulation1.00446577
59MP0003646_muscle_fatigue1.00303948
60MP0001790_abnormal_immune_system0.99078329
61MP0005387_immune_system_phenotype0.99078329
62MP0006036_abnormal_mitochondrial_physio0.98264296
63MP0002249_abnormal_larynx_morphology0.95307107
64MP0009763_increased_sensitivity_to0.93914457
65MP0008469_abnormal_protein_level0.93826099
66MP0005408_hypopigmentation0.93196113
67MP0000685_abnormal_immune_system0.93076388
68MP0001756_abnormal_urination0.92618893
69MP0009642_abnormal_blood_homeostasis0.92101991
70MP0002282_abnormal_trachea_morphology0.91323914
71MP0001485_abnormal_pinna_reflex0.91158167
72MP0005174_abnormal_tail_pigmentation0.90177773
73MP0004142_abnormal_muscle_tone0.89776623
74MP0004130_abnormal_muscle_cell0.88695886
75MP0002136_abnormal_kidney_physiology0.87952527
76MP0001873_stomach_inflammation0.87826645
77MP0005334_abnormal_fat_pad0.87628406
78MP0002419_abnormal_innate_immunity0.87064313
79MP0002254_reproductive_system_inflammat0.86537857
80MP0002971_abnormal_brown_adipose0.86018411
81MP0005666_abnormal_adipose_tissue0.85180382
82MP0005084_abnormal_gallbladder_morpholo0.83365019
83MP0005535_abnormal_body_temperature0.83281838
84MP0002078_abnormal_glucose_homeostasis0.82556696
85MP0002723_abnormal_immune_serum0.81594731
86MP0000604_amyloidosis0.80913747
87MP0003656_abnormal_erythrocyte_physiolo0.80774271
88MP0001663_abnormal_digestive_system0.78634754
89MP0005220_abnormal_exocrine_pancreas0.78258359
90MP0009765_abnormal_xenobiotic_induced0.75946875
91MP0005376_homeostasis/metabolism_phenot0.75617086
92MP0002075_abnormal_coat/hair_pigmentati0.75391988
93MP0000689_abnormal_spleen_morphology0.75322371
94MP0002938_white_spotting0.72496810
95MP0005310_abnormal_salivary_gland0.72250030
96MP0005167_abnormal_blood-brain_barrier0.69202299
97MP0003724_increased_susceptibility_to0.68839157
98MP0002452_abnormal_antigen_presenting0.68413435
99MP0001819_abnormal_immune_cell0.68243244
100MP0004782_abnormal_surfactant_physiolog0.67363956
101MP0010368_abnormal_lymphatic_system0.66991767
102MP0002420_abnormal_adaptive_immunity0.66789711
103MP0010155_abnormal_intestine_physiology0.64769750
104MP0004742_abnormal_vestibular_system0.64005970
105MP0006035_abnormal_mitochondrial_morpho0.63968019
106MP0001765_abnormal_ion_homeostasis0.63865705
107MP0003690_abnormal_glial_cell0.62007038
108MP0001529_abnormal_vocalization0.61625315
109MP0004381_abnormal_hair_follicle0.61174482
110MP0005395_other_phenotype0.59644770
111MP0005448_abnormal_energy_balance0.55904786
112MP0005266_abnormal_metabolism0.50737679
113MP0005464_abnormal_platelet_physiology0.50644596
114MP0000230_abnormal_systemic_arterial0.50619033
115MP0002928_abnormal_bile_duct0.50444713
116MP0003718_maternal_effect0.50309711
117MP0003953_abnormal_hormone_level0.49628642
118MP0002168_other_aberrant_phenotype0.49605398
119MP0003638_abnormal_response/metabolism_0.46878301
120MP0009115_abnormal_fat_cell0.46449668
121MP0000566_synostosis0.45209627
122MP0006082_CNS_inflammation0.43231486
123MP0002132_abnormal_respiratory_system0.41878545
124MP0008874_decreased_physiological_sensi0.41868193
125MP0005058_abnormal_lysosome_morphology0.41104448
126MP0003436_decreased_susceptibility_to0.40747266
127MP0003959_abnormal_lean_body0.40657620
128MP0000538_abnormal_urinary_bladder0.39871719
129MP0000639_abnormal_adrenal_gland0.39290035
130MP0002135_abnormal_kidney_morphology0.36009143
131MP0003329_amyloid_beta_deposits0.35641844
132MP0002837_dystrophic_cardiac_calcinosis0.35360660
133MP0003705_abnormal_hypodermis_morpholog0.33181466
134MP0005248_abnormal_Harderian_gland0.31611078
135MP0001845_abnormal_inflammatory_respons0.31331427
136MP0001853_heart_inflammation0.30756488
137MP0002970_abnormal_white_adipose0.30399017
138MP0008873_increased_physiological_sensi0.29140962
139MP0005166_decreased_susceptibility_to0.29081403
140MP0005375_adipose_tissue_phenotype0.27333455
141MP0000249_abnormal_blood_vessel0.26899841
142MP0008872_abnormal_physiological_respon0.26436103
143MP0003075_altered_response_to0.26149118
144MP0001324_abnormal_eye_pigmentation0.24145641
145MP0005075_abnormal_melanosome_morpholog0.23401488
146MP0008260_abnormal_autophagy0.23045115
147MP0005595_abnormal_vascular_smooth0.22679561

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)6.56226209
2Intrahepatic cholestasis (HP:0001406)6.49129532
3Deep venous thrombosis (HP:0002625)6.14601837
4Prolonged partial thromboplastin time (HP:0003645)5.85168707
5Abnormality of monocarboxylic acid metabolism (HP:0010996)5.79627630
6Xanthomatosis (HP:0000991)5.65641239
7Hypobetalipoproteinemia (HP:0003563)5.25973776
8Hyperglycinuria (HP:0003108)5.14555736
9Hyperlipoproteinemia (HP:0010980)4.96193067
10Hyperglycinemia (HP:0002154)4.77186322
11Abnormality of serine family amino acid metabolism (HP:0010894)4.76960013
12Abnormality of glycine metabolism (HP:0010895)4.76960013
13Hyperammonemia (HP:0001987)4.69240301
14Abnormality of glutamine family amino acid metabolism (HP:0010902)4.64815446
15Joint hemorrhage (HP:0005261)4.62863383
16Ketosis (HP:0001946)4.51314092
17Complement deficiency (HP:0004431)4.46431517
18Abnormality of aspartate family amino acid metabolism (HP:0010899)4.23024014
19Abnormality of sulfur amino acid metabolism (HP:0004339)4.11315615
20Hypolipoproteinemia (HP:0010981)4.10392145
21Hypoglycemic coma (HP:0001325)4.02068880
22Abnormality of fatty-acid metabolism (HP:0004359)3.95105282
23Conjugated hyperbilirubinemia (HP:0002908)3.87503758
24Abnormality of methionine metabolism (HP:0010901)3.83171239
25Epidermoid cyst (HP:0200040)3.81165853
26Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.80994088
27Abnormality of pyrimidine metabolism (HP:0004353)3.80934080
28Hypoalphalipoproteinemia (HP:0003233)3.74556330
29Fat malabsorption (HP:0002630)3.67784606
30Abnormality of the common coagulation pathway (HP:0010990)3.67166379
31Ketoacidosis (HP:0001993)3.59404373
32Abnormality of nucleobase metabolism (HP:0010932)3.42624801
33Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.40228361
34Agammaglobulinemia (HP:0004432)3.34702313
35Delayed CNS myelination (HP:0002188)3.33859791
36Abnormality of serum amino acid levels (HP:0003112)3.30661253
37Dicarboxylic aciduria (HP:0003215)3.25002182
38Abnormality of dicarboxylic acid metabolism (HP:0010995)3.25002182
39Generalized aminoaciduria (HP:0002909)3.24165664
40Abnormality of purine metabolism (HP:0004352)3.23470162
41Abnormality of complement system (HP:0005339)3.19952309
42Abnormality of the intrinsic pathway (HP:0010989)3.18485246
43Hypercholesterolemia (HP:0003124)3.14231783
44Cerebral palsy (HP:0100021)3.11225768
45Metabolic acidosis (HP:0001942)3.10473584
46Hyperbilirubinemia (HP:0002904)3.07408045
47Gout (HP:0001997)3.06750174
48Vascular calcification (HP:0004934)3.06088515
49Proximal tubulopathy (HP:0000114)3.00387186
50Lethargy (HP:0001254)2.94689345
51Steatorrhea (HP:0002570)2.75819674
52Myocardial infarction (HP:0001658)2.72565123
53Colitis (HP:0002583)2.72423947
54Cardiovascular calcification (HP:0011915)2.67878965
55Renal cortical cysts (HP:0000803)2.64175126
56Hepatocellular carcinoma (HP:0001402)2.63284726
57Panhypogammaglobulinemia (HP:0003139)2.61086619
58Cerebral edema (HP:0002181)2.60312275
59Elevated erythrocyte sedimentation rate (HP:0003565)2.60049908
60Systemic lupus erythematosus (HP:0002725)2.59782133
61Abnormality of proline metabolism (HP:0010907)2.57364755
62Hydroxyprolinuria (HP:0003080)2.57364755
63Enlarged kidneys (HP:0000105)2.56511642
64Alkalosis (HP:0001948)2.54409506
65Glycosuria (HP:0003076)2.49375778
66Abnormality of urine glucose concentration (HP:0011016)2.49375778
67Vomiting (HP:0002013)2.46641621
68Hypoglycemic seizures (HP:0002173)2.46057202
69Malnutrition (HP:0004395)2.45959591
70Abnormal number of erythroid precursors (HP:0012131)2.38922078
71Pancreatitis (HP:0001733)2.38054380
72Increased purine levels (HP:0004368)2.37088438
73Hyperuricemia (HP:0002149)2.37088438
74Spontaneous abortion (HP:0005268)2.34946113
75Glomerulonephritis (HP:0000099)2.34727374
76Abnormality of mucopolysaccharide metabolism (HP:0011020)2.33769558
77Abnormality of polysaccharide metabolism (HP:0011012)2.33769558
78Abnormality of glycosaminoglycan metabolism (HP:0004371)2.33769558
79Hypochromic microcytic anemia (HP:0004840)2.32571848
80Myositis (HP:0100614)2.31371461
81Pancreatic fibrosis (HP:0100732)2.26888639
82Cystic liver disease (HP:0006706)2.24919829
83Decreased circulating renin level (HP:0003351)2.23806779
84Chronic mucocutaneous candidiasis (HP:0002728)2.23794334
85Recurrent cutaneous fungal infections (HP:0011370)2.23794334
86Irritability (HP:0000737)2.22572698
87Type I transferrin isoform profile (HP:0003642)2.22171956
88Mucopolysacchariduria (HP:0008155)2.21585608
89Urinary glycosaminoglycan excretion (HP:0003541)2.21585608
90Rickets (HP:0002748)2.20235181
91Chronic hepatic failure (HP:0100626)2.19608539
92True hermaphroditism (HP:0010459)2.18533934
93Stomatitis (HP:0010280)2.18337704
94Nausea (HP:0002018)2.14380932
95Skin nodule (HP:0200036)2.14236973
96Mitral stenosis (HP:0001718)2.12810352
97Pancreatic cysts (HP:0001737)2.11425448
98Neonatal onset (HP:0003623)2.09747415
99Meningitis (HP:0001287)2.09658454
100Abnormal biliary tract physiology (HP:0012439)2.09424103
101Bile duct proliferation (HP:0001408)2.09424103
102Hypophosphatemic rickets (HP:0004912)2.09016362
103Absent rod-and cone-mediated responses on ERG (HP:0007688)2.08956097
104Late onset (HP:0003584)2.07818970
105Thyroid-stimulating hormone excess (HP:0002925)2.07477165
106Attenuation of retinal blood vessels (HP:0007843)2.07148901
107Spastic diplegia (HP:0001264)2.07090260
108Abnormality of transition element cation homeostasis (HP:0011030)2.06487336
109Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.06168765
110Occipital encephalocele (HP:0002085)2.05293244
111Menorrhagia (HP:0000132)2.05084455
112Nephronophthisis (HP:0000090)2.03632999
113Sensorimotor neuropathy (HP:0007141)2.02963364
114Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.02259803
115Abnormal delayed hypersensitivity skin test (HP:0002963)2.01935331
116Brushfield spots (HP:0001088)1.99121956
117Abnormal enzyme/coenzyme activity (HP:0012379)1.98456889
118Amyloidosis (HP:0011034)1.98396421
119Recurrent fungal infections (HP:0002841)1.98148208
120Esophageal varix (HP:0002040)1.97968395
121Tubulointerstitial nephritis (HP:0001970)1.97952654
122Hemorrhage of the eye (HP:0011885)1.97856863
123Cerebellar dysplasia (HP:0007033)1.97712096
124Elevated hepatic transaminases (HP:0002910)1.94908847
125Opisthotonus (HP:0002179)1.94479397
126Neurodegeneration (HP:0002180)1.93647108
127Oligomenorrhea (HP:0000876)1.93573481
128Inflammation of the large intestine (HP:0002037)1.92887173
129Tachypnea (HP:0002789)1.91564396
130Recurrent gram-negative bacterial infections (HP:0005420)1.90624769
131Methylmalonic aciduria (HP:0012120)1.90202075
132Abnormality of cells of the erythroid lineage (HP:0012130)1.88950508
133Abnormal gallbladder morphology (HP:0012437)1.87833255
134Abnormality of the renal medulla (HP:0100957)1.87793270
135Gastrointestinal inflammation (HP:0004386)1.87506904
136Confusion (HP:0001289)1.87145178
137Hyperinsulinemic hypoglycemia (HP:0000825)1.86903156
138Acanthocytosis (HP:0001927)1.86727160
139Constricted visual fields (HP:0001133)1.86500177
140Gingival bleeding (HP:0000225)1.84627896
141Albinism (HP:0001022)1.84081263
142Increased neuronal autofluorescent lipopigment (HP:0002074)1.83013477
143Abnormality of the fingertips (HP:0001211)1.82802900
144Methylmalonic acidemia (HP:0002912)1.82034694
145Dysostosis multiplex (HP:0000943)1.81992317
146Abnormality of vitamin metabolism (HP:0100508)1.81266884
147J-shaped sella turcica (HP:0002680)1.80699571
148Cholelithiasis (HP:0001081)1.79849819
149Pulmonary embolism (HP:0002204)1.79428575
150Hypochromic anemia (HP:0001931)1.78891827
151Abnormal protein N-linked glycosylation (HP:0012347)1.78612865
152Abnormal protein glycosylation (HP:0012346)1.78612865
153Abnormal glycosylation (HP:0012345)1.78612865
154Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.78612865
155Recurrent sinusitis (HP:0011108)1.78288542
156Elevated alkaline phosphatase (HP:0003155)1.76745192
157Symptomatic seizures (HP:0011145)1.76465870
158Nephritis (HP:0000123)1.76262385
159Lymphangioma (HP:0100764)1.75710810
160Congenital hepatic fibrosis (HP:0002612)1.74539940
161Homocystinuria (HP:0002156)1.74058978
162Abnormality of homocysteine metabolism (HP:0010919)1.74058978
163Thoracic kyphosis (HP:0002942)1.72937806
164Myoglobinuria (HP:0002913)1.71254061
165Large for gestational age (HP:0001520)1.70541679
166Broad alveolar ridges (HP:0000187)1.69931274

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.99895989
2SIK14.01686974
3FGFR43.85166220
4INSRR3.33052702
5ERN13.16160920
6TNK22.85835289
7TAOK32.64150226
8WNK32.16085076
9KIT2.14084357
10IRAK32.12349987
11MST1R2.07787743
12WNK41.96035655
13PIK3CG1.92529216
14ERBB41.65893574
15OXSR11.65727132
16STK38L1.64905779
17MAP4K21.64610739
18MAP3K141.62833519
19TLK11.60287358
20TYK21.55651418
21DYRK1B1.54894433
22MAPK111.53817535
23PINK11.53804070
24FLT31.44191731
25LATS11.42887979
26PIM21.35580798
27PRKAA21.27866708
28BTK1.23392421
29IRAK21.21283508
30PDK21.20751805
31NEK91.20253099
32FGFR21.18885428
33NME11.17626712
34IRAK11.17167736
35MAP2K41.13809065
36TIE11.11901264
37SYK1.10277561
38EPHB11.09358343
39RPS6KA61.09138914
40RPS6KL11.07161269
41RPS6KC11.07161269
42FES1.04449426
43PTK61.01844734
44NUAK11.01767321
45FRK0.99815392
46PRKD20.98954932
47BLK0.97871803
48PDK40.97003008
49PDK30.97003008
50IKBKE0.96888126
51ABL20.96291061
52GRK10.95268905
53MARK20.95254272
54MAPKAPK30.94758990
55CAMK1D0.92321120
56MAPK120.91535872
57PKN20.91272311
58JAK10.90616990
59MAP2K20.90463768
60SGK20.90296327
61SIK20.87504378
62MAPK130.87489034
63ITK0.87155219
64TGFBR20.85917877
65AKT30.84742137
66SGK2230.84093947
67SGK4940.84093947
68KDR0.82830620
69CHUK0.82161179
70MAPK40.81309747
71CDC42BPA0.80517882
72MAP3K70.79509306
73CDK30.79252188
74JAK20.79130754
75SGK30.77919197
76STK390.77693467
77MAP3K60.77648545
78LYN0.76088282
79MATK0.72184177
80NTRK20.72097066
81RPS6KA20.70983989
82MAPK150.70370512
83LCK0.70144652
84PRKAA10.70070546
85TEC0.68876070
86TBK10.68542329
87MAP4K10.68509969
88MET0.68213261
89DYRK20.67967652
90PRKCZ0.67957448
91GSK3A0.67711218
92GRK60.67312017
93ICK0.67211346
94MAP3K30.67094001
95VRK20.66848655
96PRKCQ0.66227087
97CAMK10.65907665
98RPS6KA50.64694791
99EPHB20.63903727
100MAP2K30.63540741
101OBSCN0.63098124
102ZAK0.62839290
103PRKD10.62407942
104CSK0.62240072
105PRKACG0.61374388
106FGR0.60547666
107RET0.58847467
108MAPK70.58694836
109IRAK40.58660452
110HCK0.58498335
111PIK3CA0.58048170
112RIPK40.57863347
113PKN10.57568720
114MAPK30.57315565
115PASK0.56901747
116FER0.56551640
117HIPK20.56264118
118MTOR0.56141018
119ADRBK20.55389609
120CAMK1G0.54961752
121EPHA30.54701011
122FGFR30.53620552
123CDK120.53584197
124EPHA20.52966435
125ZAP700.52724963
126DAPK20.52039784
127CSF1R0.51957153
128STK160.51901638
129ERBB20.51356190
130IKBKB0.51347341
131CDK60.51053392
132EPHA40.50396467
133MAP3K110.49240252
134RPS6KB20.48012935
135PNCK0.47124258
136PDPK10.46718123
137NME20.46219435
138STK110.45802660
139PTK20.45001330
140IGF1R0.42954549
141TRIB30.42770899
142MAP2K60.42693221
143MAP3K130.41676160
144CAMK2G0.40850405
145TAOK20.40517850
146JAK30.40224593
147TXK0.37725479
148PDK10.36828830
149NEK60.36597191
150MYLK0.36462293
151EIF2AK20.36345916
152CSNK1G10.36001764

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.99423529
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.33241807
3Nitrogen metabolism_Homo sapiens_hsa009102.88400558
4Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.79557090
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.76570029
6Tryptophan metabolism_Homo sapiens_hsa003802.73150975
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.70858084
8Fatty acid degradation_Homo sapiens_hsa000712.70607404
9Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.67697299
10Arginine biosynthesis_Homo sapiens_hsa002202.64878317
11Pentose and glucuronate interconversions_Homo sapiens_hsa000402.46151501
12Propanoate metabolism_Homo sapiens_hsa006402.42992019
13Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.42922769
14Complement and coagulation cascades_Homo sapiens_hsa046102.40644035
15Butanoate metabolism_Homo sapiens_hsa006502.36672314
16Peroxisome_Homo sapiens_hsa041462.26551940
17Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.11927949
18Fatty acid metabolism_Homo sapiens_hsa012122.07005745
19PPAR signaling pathway_Homo sapiens_hsa033201.98357948
20beta-Alanine metabolism_Homo sapiens_hsa004101.94736173
21Histidine metabolism_Homo sapiens_hsa003401.92897779
22Steroid hormone biosynthesis_Homo sapiens_hsa001401.91770497
23Chemical carcinogenesis_Homo sapiens_hsa052041.89347160
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.89192771
25Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.88598235
26Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.79504311
272-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.71473817
28Retinol metabolism_Homo sapiens_hsa008301.69173482
29Drug metabolism - other enzymes_Homo sapiens_hsa009831.68517154
30Caffeine metabolism_Homo sapiens_hsa002321.66240198
31Staphylococcus aureus infection_Homo sapiens_hsa051501.61591379
32Fatty acid elongation_Homo sapiens_hsa000621.54073410
33Pyruvate metabolism_Homo sapiens_hsa006201.51580054
34Sulfur metabolism_Homo sapiens_hsa009201.50306117
35Phenylalanine metabolism_Homo sapiens_hsa003601.49377869
36Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.47080662
37Selenocompound metabolism_Homo sapiens_hsa004501.41579731
38Bile secretion_Homo sapiens_hsa049761.39176941
39Tyrosine metabolism_Homo sapiens_hsa003501.38252993
40Starch and sucrose metabolism_Homo sapiens_hsa005001.35898614
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.33005007
42ABC transporters_Homo sapiens_hsa020101.26485767
43Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.23321492
44Carbon metabolism_Homo sapiens_hsa012001.19057590
45Intestinal immune network for IgA production_Homo sapiens_hsa046721.18634352
46Vitamin digestion and absorption_Homo sapiens_hsa049771.18008454
47Primary immunodeficiency_Homo sapiens_hsa053401.17894297
48Steroid biosynthesis_Homo sapiens_hsa001001.16582035
49Cyanoamino acid metabolism_Homo sapiens_hsa004601.14727882
50Folate biosynthesis_Homo sapiens_hsa007901.14704313
51Arginine and proline metabolism_Homo sapiens_hsa003301.07902553
52Cysteine and methionine metabolism_Homo sapiens_hsa002701.06823371
53Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.05928615
54Fat digestion and absorption_Homo sapiens_hsa049751.04836848
55Biosynthesis of amino acids_Homo sapiens_hsa012301.04311134
56Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.99448000
57Maturity onset diabetes of the young_Homo sapiens_hsa049500.99241540
58Asthma_Homo sapiens_hsa053100.97608135
59Allograft rejection_Homo sapiens_hsa053300.97171648
60Lysine degradation_Homo sapiens_hsa003100.95675864
61Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.91835796
62Vitamin B6 metabolism_Homo sapiens_hsa007500.90729538
63Autoimmune thyroid disease_Homo sapiens_hsa053200.89300120
64Sulfur relay system_Homo sapiens_hsa041220.87674068
65Glycerolipid metabolism_Homo sapiens_hsa005610.83913793
66Glutathione metabolism_Homo sapiens_hsa004800.74875065
67Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.72365080
68Fatty acid biosynthesis_Homo sapiens_hsa000610.70267867
69One carbon pool by folate_Homo sapiens_hsa006700.68994841
70Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.66507679
71Graft-versus-host disease_Homo sapiens_hsa053320.63674265
72Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.59339422
73Leishmaniasis_Homo sapiens_hsa051400.56319603
74Pentose phosphate pathway_Homo sapiens_hsa000300.55729931
75Metabolic pathways_Homo sapiens_hsa011000.55695331
76Antigen processing and presentation_Homo sapiens_hsa046120.51367894
77Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.48443344
78Notch signaling pathway_Homo sapiens_hsa043300.43008602
79Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.40639581
80alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.39164812
81Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.39129239
82Fructose and mannose metabolism_Homo sapiens_hsa000510.37543782
83Type I diabetes mellitus_Homo sapiens_hsa049400.33697656
84Linoleic acid metabolism_Homo sapiens_hsa005910.30503225
85Systemic lupus erythematosus_Homo sapiens_hsa053220.30383213
86Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.29831426
87Adipocytokine signaling pathway_Homo sapiens_hsa049200.24187342
88Galactose metabolism_Homo sapiens_hsa000520.23515783
89Insulin resistance_Homo sapiens_hsa049310.22871475
90Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.22774935
91N-Glycan biosynthesis_Homo sapiens_hsa005100.21904387
92Longevity regulating pathway - mammal_Homo sapiens_hsa042110.19928118
93Choline metabolism in cancer_Homo sapiens_hsa052310.19030924
94Glycerophospholipid metabolism_Homo sapiens_hsa005640.17532851
95Sphingolipid metabolism_Homo sapiens_hsa006000.17449850
96Platelet activation_Homo sapiens_hsa046110.15912341
97Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.15637525
98Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.14962151
99Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.14879689
100Arachidonic acid metabolism_Homo sapiens_hsa005900.12870730
101Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.08578224
102Prion diseases_Homo sapiens_hsa050200.08196529
103Glycosaminoglycan degradation_Homo sapiens_hsa005310.06502646
104Glucagon signaling pathway_Homo sapiens_hsa049220.05871130
105Other glycan degradation_Homo sapiens_hsa005110.02170933
106AMPK signaling pathway_Homo sapiens_hsa041520.01980661
107Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.2123637
108RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622-0.2067662
109Oxidative phosphorylation_Homo sapiens_hsa00190-0.2003143
110African trypanosomiasis_Homo sapiens_hsa05143-0.1865600
111Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1854587
112Ether lipid metabolism_Homo sapiens_hsa00565-0.1611636
113Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563-0.1593859
114Insulin signaling pathway_Homo sapiens_hsa04910-0.1591424
115Hepatitis C_Homo sapiens_hsa05160-0.1525413
116Lysosome_Homo sapiens_hsa04142-0.1509478
117Mineral absorption_Homo sapiens_hsa04978-0.1143573
118Protein digestion and absorption_Homo sapiens_hsa04974-0.0878687
119Renin-angiotensin system_Homo sapiens_hsa04614-0.0692834
120Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0665320
121Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0586225
122Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0109623
123Regulation of autophagy_Homo sapiens_hsa04140-0.0086291

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