ACAD11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an acyl-CoA dehydrogenase enzyme with a preference for carbon chain lengths between 20 and 26. Naturally occurring read-through transcription occurs between the upstream gene NPHP3 (nephronophthisis 3 (adolescent)) and this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.03727403
2L-phenylalanine catabolic process (GO:0006559)7.03727403
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.74543203
4L-phenylalanine metabolic process (GO:0006558)6.74543203
5exogenous drug catabolic process (GO:0042738)6.73111721
6epoxygenase P450 pathway (GO:0019373)6.50821686
7aromatic amino acid family catabolic process (GO:0009074)6.33138349
8triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.86561122
9indole-containing compound catabolic process (GO:0042436)5.70912115
10indolalkylamine catabolic process (GO:0046218)5.70912115
11tryptophan catabolic process (GO:0006569)5.70912115
12alpha-linolenic acid metabolic process (GO:0036109)5.68653581
13kynurenine metabolic process (GO:0070189)5.65807274
14glyoxylate metabolic process (GO:0046487)5.63896838
15omega-hydroxylase P450 pathway (GO:0097267)5.61719875
16bile acid biosynthetic process (GO:0006699)5.50526573
17tryptophan metabolic process (GO:0006568)5.40608638
18fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.22951991
19cysteine metabolic process (GO:0006534)5.19735704
20sulfur amino acid catabolic process (GO:0000098)5.17781793
21urea cycle (GO:0000050)5.15815536
22urea metabolic process (GO:0019627)5.15815536
23lysine metabolic process (GO:0006553)5.11623227
24lysine catabolic process (GO:0006554)5.11623227
25blood coagulation, intrinsic pathway (GO:0007597)5.05211241
26high-density lipoprotein particle remodeling (GO:0034375)4.94908819
27serine family amino acid catabolic process (GO:0009071)4.86684041
28negative regulation of fibrinolysis (GO:0051918)4.86621588
29complement activation, alternative pathway (GO:0006957)4.84803893
30regulation of triglyceride catabolic process (GO:0010896)4.82855971
31very-low-density lipoprotein particle assembly (GO:0034379)4.80110581
32amino-acid betaine metabolic process (GO:0006577)4.79917108
33homocysteine metabolic process (GO:0050667)4.78811810
34protein carboxylation (GO:0018214)4.78473643
35peptidyl-glutamic acid carboxylation (GO:0017187)4.78473643
36nitrogen cycle metabolic process (GO:0071941)4.75637492
37bile acid metabolic process (GO:0008206)4.74791609
38regulation of protein activation cascade (GO:2000257)4.70753611
39drug metabolic process (GO:0017144)4.69757169
40regulation of fibrinolysis (GO:0051917)4.67312515
41fibrinolysis (GO:0042730)4.62264382
42aromatic amino acid family metabolic process (GO:0009072)4.60382599
43cellular ketone body metabolic process (GO:0046950)4.56990650
44regulation of plasminogen activation (GO:0010755)4.55321659
45alpha-amino acid catabolic process (GO:1901606)4.50011809
46acylglycerol homeostasis (GO:0055090)4.46239202
47triglyceride homeostasis (GO:0070328)4.46239202
48positive regulation of heterotypic cell-cell adhesion (GO:0034116)4.44780139
49ethanol metabolic process (GO:0006067)4.42924179
50tyrosine metabolic process (GO:0006570)4.42348351
51regulation of complement activation (GO:0030449)4.40447514
52reverse cholesterol transport (GO:0043691)4.38935798
53negative regulation of protein activation cascade (GO:2000258)4.36742732
54regulation of cholesterol esterification (GO:0010872)4.35060522
55protein-lipid complex remodeling (GO:0034368)4.33006296
56macromolecular complex remodeling (GO:0034367)4.33006296
57plasma lipoprotein particle remodeling (GO:0034369)4.33006296
58protein-lipid complex assembly (GO:0065005)4.25561151
59plasma lipoprotein particle clearance (GO:0034381)4.21413416
60cellular amino acid catabolic process (GO:0009063)4.21148072
61phospholipid efflux (GO:0033700)4.17674652
62negative regulation of cholesterol transport (GO:0032375)4.16376148
63negative regulation of sterol transport (GO:0032372)4.16376148
64short-chain fatty acid metabolic process (GO:0046459)4.16159042
65ethanol oxidation (GO:0006069)4.13286273
66acetyl-CoA metabolic process (GO:0006084)4.11532386
67intestinal cholesterol absorption (GO:0030299)4.09921753
68oxidative demethylation (GO:0070989)4.09184480
69coenzyme catabolic process (GO:0009109)4.09147146
70* fatty acid beta-oxidation (GO:0006635)4.07450695
71bile acid and bile salt transport (GO:0015721)4.05230580
72indolalkylamine metabolic process (GO:0006586)4.04802391
73protein activation cascade (GO:0072376)4.04339612
74cellular glucuronidation (GO:0052695)4.00741850
75glutamate metabolic process (GO:0006536)3.99499178
76glycine metabolic process (GO:0006544)3.98222879
77plasma lipoprotein particle organization (GO:0071827)3.97105062
78* fatty acid oxidation (GO:0019395)3.95728373
79ketone body metabolic process (GO:1902224)3.95727177
80serine family amino acid metabolic process (GO:0009069)3.95439526
812-oxoglutarate metabolic process (GO:0006103)3.94198767
82benzene-containing compound metabolic process (GO:0042537)3.93460059
83cellular modified amino acid catabolic process (GO:0042219)3.92881763
84phenylpropanoid metabolic process (GO:0009698)3.92342738
85cellular biogenic amine catabolic process (GO:0042402)3.90450204
86amine catabolic process (GO:0009310)3.90450204
87* lipid oxidation (GO:0034440)3.88220934
88drug catabolic process (GO:0042737)3.88038711
89* carboxylic acid catabolic process (GO:0046395)3.86323527
90* organic acid catabolic process (GO:0016054)3.86323527
91dicarboxylic acid biosynthetic process (GO:0043650)3.85499066
92regulation of humoral immune response (GO:0002920)3.85404531
93aspartate family amino acid catabolic process (GO:0009068)3.85268549
94positive regulation of lipid catabolic process (GO:0050996)3.84692794
95* fatty acid catabolic process (GO:0009062)3.83664610
96positive regulation of fatty acid beta-oxidation (GO:0032000)3.83649678
97phospholipid homeostasis (GO:0055091)3.83233385
98* monocarboxylic acid catabolic process (GO:0072329)3.82742952
99cholesterol efflux (GO:0033344)3.80350109
100carnitine metabolic process (GO:0009437)3.79478177
101protein-lipid complex subunit organization (GO:0071825)3.77936675
102imidazole-containing compound metabolic process (GO:0052803)3.77010491
103negative regulation of blood coagulation (GO:0030195)3.73042646
104negative regulation of hemostasis (GO:1900047)3.73042646
105valine metabolic process (GO:0006573)3.70728234
106serine family amino acid biosynthetic process (GO:0009070)3.68669204
107complement activation, classical pathway (GO:0006958)3.67293412
108S-adenosylmethionine metabolic process (GO:0046500)3.65752770
109plasma lipoprotein particle assembly (GO:0034377)3.65238077
110positive regulation of triglyceride lipase activity (GO:0061365)3.61943026
111positive regulation of lipoprotein lipase activity (GO:0051006)3.61943026
112arginine metabolic process (GO:0006525)3.61549938
113negative regulation of lipase activity (GO:0060192)3.61199835
114drug transmembrane transport (GO:0006855)3.61086916
115cholesterol homeostasis (GO:0042632)3.60673488
116complement activation (GO:0006956)3.59913306
117regulation of bile acid biosynthetic process (GO:0070857)3.58613521
118regulation of cholesterol homeostasis (GO:2000188)3.57458844
119low-density lipoprotein particle remodeling (GO:0034374)3.56945798
120uronic acid metabolic process (GO:0006063)3.56250252
121glucuronate metabolic process (GO:0019585)3.56250252
122aldehyde catabolic process (GO:0046185)3.55842415
123sterol homeostasis (GO:0055092)3.55414102
124fatty acid transmembrane transport (GO:1902001)3.54598632
125regulation of apoptotic cell clearance (GO:2000425)3.50131819
126acute-phase response (GO:0006953)3.43500374
127lipoprotein metabolic process (GO:0042157)3.40882435
128negative regulation of coagulation (GO:0050819)3.40413874
129negative regulation of wound healing (GO:0061045)3.36507240
130negative regulation of complement activation (GO:0045916)3.29230143
131positive regulation of blood coagulation (GO:0030194)3.27960084
132positive regulation of hemostasis (GO:1900048)3.27960084
133polyketide metabolic process (GO:0030638)3.27604516
134doxorubicin metabolic process (GO:0044598)3.27604516
135daunorubicin metabolic process (GO:0044597)3.27604516
136regulation of cholesterol metabolic process (GO:0090181)3.20460155
137lipoprotein transport (GO:0042953)3.20215377
138sterol transport (GO:0015918)3.12166509
139cholesterol transport (GO:0030301)3.12166509
140negative regulation of fatty acid biosynthetic process (GO:0045717)3.11934680
141response to mercury ion (GO:0046689)3.11514677

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse7.94456526
2PPARA_22158963_ChIP-Seq_LIVER_Mouse6.86610407
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.33378329
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.26392102
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.09399188
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.04756983
7* CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.52811362
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.99757497
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.52012495
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.09641247
11TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.71508087
12GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.29667682
13RBPJ_22232070_ChIP-Seq_NCS_Mouse2.15447745
14CDX2_19796622_ChIP-Seq_MESCs_Mouse2.10068052
15TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.03937705
16HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.02214941
17ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.1462350
18CLOCK_20551151_ChIP-Seq_293T_Human1.86287747
19TRIM28_21343339_ChIP-Seq_HEK293_Human1.66259218
20FOXA2_19822575_ChIP-Seq_HepG2_Human1.64889627
21TP53_16413492_ChIP-PET_HCT116_Human1.63481436
22GATA1_22025678_ChIP-Seq_K562_Human1.63148906
23EP300_21415370_ChIP-Seq_HL-1_Mouse1.62159325
24PIAS1_25552417_ChIP-Seq_VCAP_Human1.56739672
25POU3F2_20337985_ChIP-ChIP_501MEL_Human1.44903799
26IGF1R_20145208_ChIP-Seq_DFB_Human1.42132975
27* HNF4A_19822575_ChIP-Seq_HepG2_Human1.40451842
28STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.39990851
29CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.39013086
30HTT_18923047_ChIP-ChIP_STHdh_Human1.37285809
31AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.33005272
32TP53_18474530_ChIP-ChIP_U2OS_Human1.30246739
33GBX2_23144817_ChIP-Seq_PC3_Human1.29852618
34PCGF2_27294783_Chip-Seq_NPCs_Mouse1.26012659
35HIF1A_21447827_ChIP-Seq_MCF-7_Human1.24894073
36TCF4_18268006_ChIP-ChIP_LS174T_Human1.24725315
37THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.19151434
38PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.18105287
39ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.17264153
40STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.14103421
41SALL1_21062744_ChIP-ChIP_HESCs_Human1.12804062
42SOX2_27498859_Chip-Seq_STOMACH_Mouse1.11471072
43PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.10722237
44RARG_19884340_ChIP-ChIP_MEFs_Mouse1.10109301
45PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.05656605
46SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.05306942
47EZH2_27294783_Chip-Seq_NPCs_Mouse1.05114712
48STAT3_23295773_ChIP-Seq_U87_Human1.04901636
49RXRA_24833708_ChIP-Seq_LIVER_Mouse1.04901079
50TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.04079472
51IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.03819202
52SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01174520
53ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.98768769
54CTNNB1_20460455_ChIP-Seq_HCT116_Human0.97846277
55SUZ12_27294783_Chip-Seq_NPCs_Mouse0.97764922
56ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.95796842
57NFE2_27457419_Chip-Seq_LIVER_Mouse0.95244316
58* GATA4_25053715_ChIP-Seq_YYC3_Human0.94056676
59CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.93925685
60BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.92273795
61ZNF263_19887448_ChIP-Seq_K562_Human0.91494769
62TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.89116095
63ESR2_21235772_ChIP-Seq_MCF-7_Human0.87671693
64TCF4_23295773_ChIP-Seq_U87_Human0.87442811
65SMAD4_21799915_ChIP-Seq_A2780_Human0.85344768
66MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.84186865
67AUTS2_25519132_ChIP-Seq_293T-REX_Human0.83410068
68CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.83311643
69AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.82326627
70PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.82274647
71TCF4_22108803_ChIP-Seq_LS180_Human0.80753198
72CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.79629335
73MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.79035259
74Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.78414794
75EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.78275753
76NR3C1_21868756_ChIP-Seq_MCF10A_Human0.77916033
77CRX_20693478_ChIP-Seq_RETINA_Mouse0.76253548
78NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.76186128
79NRF2_20460467_ChIP-Seq_MEFs_Mouse0.76186128
80P300_19829295_ChIP-Seq_ESCs_Human0.76175827
81WT1_19549856_ChIP-ChIP_CCG9911_Human0.75598656
82FLI1_27457419_Chip-Seq_LIVER_Mouse0.75000626
83CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.74684222
84SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.74573796
85OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.74393805
86SALL4_18804426_ChIP-ChIP_XEN_Mouse0.74074137
87NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.73422265
88PCGF2_27294783_Chip-Seq_ESCs_Mouse0.73383371
89PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.72487968
90SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.72343406
91CBP_20019798_ChIP-Seq_JUKART_Human0.72230487
92IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.72230487
93CJUN_26792858_Chip-Seq_BT549_Human0.71997152
94OCT4_21477851_ChIP-Seq_ESCs_Mouse0.71632234
95ESR1_20079471_ChIP-ChIP_T-47D_Human0.71136204
96NANOG_18555785_Chip-Seq_ESCs_Mouse0.70347206
97ESR1_21235772_ChIP-Seq_MCF-7_Human0.69960399
98GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.69907691
99IRF8_22096565_ChIP-ChIP_GC-B_Human0.69361474
100PPAR_26484153_Chip-Seq_NCI-H1993_Human0.69316905
101ETV2_25802403_ChIP-Seq_MESCs_Mouse0.69031112
102ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.68963206
103SMAD4_21741376_ChIP-Seq_HESCs_Human0.68188775
104KAP1_22055183_ChIP-Seq_ESCs_Mouse0.67689768
105ZFP57_27257070_Chip-Seq_ESCs_Mouse0.67657724
106KLF5_20875108_ChIP-Seq_MESCs_Mouse0.67581443
107ESR1_15608294_ChIP-ChIP_MCF-7_Human0.67244471
108BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.65869742
109RAD21_21589869_ChIP-Seq_MESCs_Mouse0.64736811
110CEBPB_22108803_ChIP-Seq_LS180_Human0.64333392
111SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.64062940
112PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.63571720
113RARA_24833708_ChIP-Seq_LIVER_Mouse0.62900927
114FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.62809850
115TBX20_22080862_ChIP-Seq_HEART_Mouse0.62447024
116TBX20_22328084_ChIP-Seq_HEART_Mouse0.62447024
117FOXO3_23340844_ChIP-Seq_DLD1_Human0.62109294
118NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.61369780
119CDX2_20551321_ChIP-Seq_CACO-2_Human0.60830243
120FOXA1_25552417_ChIP-Seq_VCAP_Human0.59406270
121PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.59205519
122STAT3_1855785_ChIP-Seq_MESCs_Mouse0.58610902
123RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.57937621
124CBP_21632823_ChIP-Seq_H3396_Human0.55267176
125AR_20517297_ChIP-Seq_VCAP_Human0.54667538
126FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.53817233
127RARB_24833708_ChIP-Seq_LIVER_Mouse0.52558607
128ESET_19884257_ChIP-Seq_ESCs_Mouse0.52009474
129GATA2_19941826_ChIP-Seq_K562_Human0.51942189
130BCAT_22108803_ChIP-Seq_LS180_Human0.51693396
131LXR_22292898_ChIP-Seq_THP-1_Human0.51266973
132GATA6_25053715_ChIP-Seq_YYC3_Human0.50556073
133GATA1_19941826_ChIP-Seq_K562_Human0.50552013
134ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.50339892
135* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.48240056
136MYC_19915707_ChIP-ChIP_AK7_Human0.48221708
137EGR1_19032775_ChIP-ChIP_M12_Human0.47952757
138* STAT1_17558387_ChIP-Seq_HELA_Human0.47654402
139TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.46326854
140TAF2_19829295_ChIP-Seq_ESCs_Human0.45742434
141CDX2_22108803_ChIP-Seq_LS180_Human0.45619260
142* SOX2_20726797_ChIP-Seq_SW620_Human0.45488275
143EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.45197238
144PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.44648158
145GATA1_19941827_ChIP-Seq_MEL_Mouse0.44251842
146* GATA3_24758297_ChIP-Seq_MCF-7_Human0.43815188
147PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.43102850
148ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.42470813
149* P53_21459846_ChIP-Seq_SAOS-2_Human0.41415533
150GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.41070621
151ERG_20517297_ChIP-Seq_VCAP_Human0.39797421
152FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.39150981
153SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.38378750
154OCT4_20526341_ChIP-Seq_ESCs_Human0.37683792
155CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.37532882
156FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.37354655

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.88319629
2MP0005360_urolithiasis7.23103705
3MP0005085_abnormal_gallbladder_physiolo6.04748529
4MP0005365_abnormal_bile_salt5.94037999
5MP0008875_abnormal_xenobiotic_pharmacok4.88677967
6MP0003806_abnormal_nucleotide_metabolis4.07073291
7MP0003252_abnormal_bile_duct3.78747911
8MP0010329_abnormal_lipoprotein_level3.55888277
9MP0009840_abnormal_foam_cell2.99151841
10MP0005332_abnormal_amino_acid2.90164603
11MP0003195_calcinosis2.80901248
12MP0005083_abnormal_biliary_tract2.78206373
13MP0001666_abnormal_nutrient_absorption2.57333292
14MP0003191_abnormal_cellular_cholesterol2.34666257
15MP0004019_abnormal_vitamin_homeostasis2.25101744
16MP0002118_abnormal_lipid_homeostasis2.22429810
17MP0004272_abnormal_basement_membrane2.19532090
18MP0000609_abnormal_liver_physiology2.13167290
19MP0002138_abnormal_hepatobiliary_system1.93477420
20MP0005319_abnormal_enzyme/_coenzyme1.86066021
21MP0005670_abnormal_white_adipose1.75420788
22MP0003868_abnormal_feces_composition1.69054623
23MP0001764_abnormal_homeostasis1.63997103
24MP0005584_abnormal_enzyme/coenzyme_acti1.62568145
25MP0005451_abnormal_body_composition1.56753765
26MP0003122_maternal_imprinting1.49043882
27MP0009643_abnormal_urine_homeostasis1.48414645
28MP0002837_dystrophic_cardiac_calcinosis1.46528832
29MP0004130_abnormal_muscle_cell1.42692695
30MP0003186_abnormal_redox_activity1.38641753
31MP0008438_abnormal_cutaneous_collagen1.38090491
32MP0009697_abnormal_copulation1.31849719
33MP0005503_abnormal_tendon_morphology1.28030885
34MP0000566_synostosis1.27575430
35MP0001984_abnormal_olfaction1.26155694
36MP0003011_delayed_dark_adaptation1.24684734
37MP0009780_abnormal_chondrocyte_physiolo1.20184041
38MP0006036_abnormal_mitochondrial_physio1.17141473
39MP0003705_abnormal_hypodermis_morpholog1.13855259
40MP0005666_abnormal_adipose_tissue1.11873475
41MP0000598_abnormal_liver_morphology1.09759049
42MP0002971_abnormal_brown_adipose1.06557469
43MP0005647_abnormal_sex_gland1.05093186
44MP0003656_abnormal_erythrocyte_physiolo1.05060247
45MP0002254_reproductive_system_inflammat1.04515574
46MP0001986_abnormal_taste_sensitivity1.02647849
47MP0002132_abnormal_respiratory_system1.02203729
48MP0002876_abnormal_thyroid_physiology1.02167854
49MP0005636_abnormal_mineral_homeostasis1.00750874
50MP0009764_decreased_sensitivity_to0.97086792
51MP0002078_abnormal_glucose_homeostasis0.95623058
52MP0009763_increased_sensitivity_to0.95550944
53MP0003879_abnormal_hair_cell0.94787607
54MP0005334_abnormal_fat_pad0.90819241
55MP0005535_abnormal_body_temperature0.90769522
56MP0001915_intracranial_hemorrhage0.89149356
57MP0000604_amyloidosis0.89134009
58MP0010368_abnormal_lymphatic_system0.87152130
59MP0009642_abnormal_blood_homeostasis0.86920149
60MP0001661_extended_life_span0.85354743
61MP0001756_abnormal_urination0.83310242
62MP0004043_abnormal_pH_regulation0.82433955
63MP0002282_abnormal_trachea_morphology0.81740150
64MP0005084_abnormal_gallbladder_morpholo0.81267871
65MP0002295_abnormal_pulmonary_circulatio0.80956229
66MP0008469_abnormal_protein_level0.80585264
67MP0005376_homeostasis/metabolism_phenot0.79413567
68MP0004084_abnormal_cardiac_muscle0.78045420
69MP0008775_abnormal_heart_ventricle0.77176098
70MP0005266_abnormal_metabolism0.76450432
71MP0005187_abnormal_penis_morphology0.75076670
72MP0003690_abnormal_glial_cell0.73355935
73MP0005408_hypopigmentation0.70659799
74MP0001270_distended_abdomen0.70443429
75MP0006035_abnormal_mitochondrial_morpho0.69113756
76MP0005448_abnormal_energy_balance0.68199947
77MP0009765_abnormal_xenobiotic_induced0.68020001
78MP0005220_abnormal_exocrine_pancreas0.65412577
79MP0005023_abnormal_wound_healing0.65235661
80MP0003950_abnormal_plasma_membrane0.65124204
81MP0000751_myopathy0.63185234
82MP0002136_abnormal_kidney_physiology0.61698654
83MP0003646_muscle_fatigue0.60941979
84MP0004185_abnormal_adipocyte_glucose0.60533310
85MP0001299_abnormal_eye_distance/0.58909340
86MP0005330_cardiomyopathy0.58272425
87MP0002233_abnormal_nose_morphology0.57565796
88MP0005164_abnormal_response_to0.57384464
89MP0009115_abnormal_fat_cell0.57000613
90MP0003183_abnormal_peptide_metabolism0.56918120
91MP0008789_abnormal_olfactory_epithelium0.56659598
92MP0000013_abnormal_adipose_tissue0.56486676
93MP0005375_adipose_tissue_phenotype0.56067333
94MP0002128_abnormal_blood_circulation0.55849968
95MP0002697_abnormal_eye_size0.54922665
96MP0002249_abnormal_larynx_morphology0.54444316
97MP0002822_catalepsy0.53573704
98MP0000230_abnormal_systemic_arterial0.53488302
99MP0003329_amyloid_beta_deposits0.53216842
100MP0001293_anophthalmia0.53033005
101MP0003953_abnormal_hormone_level0.51015119
102MP0006054_spinal_hemorrhage0.50684975
103MP0003718_maternal_effect0.49580889
104MP0004215_abnormal_myocardial_fiber0.48280266
105MP0009379_abnormal_foot_pigmentation0.47641789
106MP0002970_abnormal_white_adipose0.47538161
107MP0003724_increased_susceptibility_to0.47536012
108MP0010030_abnormal_orbit_morphology0.47447302
109MP0002108_abnormal_muscle_morphology0.46469516
110MP0002928_abnormal_bile_duct0.46148941
111MP0002796_impaired_skin_barrier0.46135443
112MP0004036_abnormal_muscle_relaxation0.45739599
113MP0002234_abnormal_pharynx_morphology0.45007163
114MP0002269_muscular_atrophy0.44863226
115MP0003279_aneurysm0.44765343
116MP0005395_other_phenotype0.43816025
117MP0000003_abnormal_adipose_tissue0.43265481
118MP0001765_abnormal_ion_homeostasis0.42474517
119MP0000639_abnormal_adrenal_gland0.42013229
120MP0003638_abnormal_response/metabolism_0.41558896
121MP0008874_decreased_physiological_sensi0.40819944
122MP0004782_abnormal_surfactant_physiolog0.37867650
123MP0002168_other_aberrant_phenotype0.37774879
124MP0005058_abnormal_lysosome_morphology0.37465323
125MP0009053_abnormal_anal_canal0.36792671
126MP0008873_increased_physiological_sensi0.36322914
127MP0003959_abnormal_lean_body0.36211926
128MP0009672_abnormal_birth_weight0.35851474
129MP0009384_cardiac_valve_regurgitation0.34415417
130MP0001853_heart_inflammation0.34228074
131MP0003075_altered_response_to0.33569936
132MP0008872_abnormal_physiological_respon0.33260044
133MP0005167_abnormal_blood-brain_barrier0.32924621
134MP0005464_abnormal_platelet_physiology0.32135553
135MP0006138_congestive_heart_failure0.31818622
136MP0000249_abnormal_blood_vessel0.31083937
137MP0002060_abnormal_skin_morphology0.30414522
138MP0005166_decreased_susceptibility_to0.30407122
139MP0001881_abnormal_mammary_gland0.29640698
140MP0000579_abnormal_nail_morphology0.28898793

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)6.63726390
2Abnormality of aromatic amino acid family metabolism (HP:0004338)6.57510600
3Deep venous thrombosis (HP:0002625)6.41529758
4Xanthomatosis (HP:0000991)5.94857124
5Abnormality of monocarboxylic acid metabolism (HP:0010996)5.86044841
6Hypobetalipoproteinemia (HP:0003563)5.66827748
7Prolonged partial thromboplastin time (HP:0003645)5.63943727
8Hyperlipoproteinemia (HP:0010980)5.11753649
9Hyperammonemia (HP:0001987)4.83780498
10Complement deficiency (HP:0004431)4.72128643
11Hyperglycinuria (HP:0003108)4.67309549
12Ketosis (HP:0001946)4.67069316
13Hyperglycinemia (HP:0002154)4.51840130
14Hypolipoproteinemia (HP:0010981)4.51182356
15Hypoglycemic coma (HP:0001325)4.45318443
16Abnormality of glycine metabolism (HP:0010895)4.43760425
17Abnormality of serine family amino acid metabolism (HP:0010894)4.43760425
18Epidermoid cyst (HP:0200040)4.36178163
19Abnormality of glutamine family amino acid metabolism (HP:0010902)4.24093083
20Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.18454139
21Joint hemorrhage (HP:0005261)4.18147031
22Hypoalphalipoproteinemia (HP:0003233)4.15277082
23Abnormality of fatty-acid metabolism (HP:0004359)4.10745962
24Abnormality of aspartate family amino acid metabolism (HP:0010899)4.04678502
25Abnormality of sulfur amino acid metabolism (HP:0004339)3.95912644
26Abnormality of the common coagulation pathway (HP:0010990)3.90775923
27Abnormality of methionine metabolism (HP:0010901)3.87836009
28Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.82505489
29Ketoacidosis (HP:0001993)3.75451381
30Fat malabsorption (HP:0002630)3.74583355
31Abnormality of the intrinsic pathway (HP:0010989)3.42437443
32Hypercholesterolemia (HP:0003124)3.38646600
33Conjugated hyperbilirubinemia (HP:0002908)3.38034411
34Abnormality of complement system (HP:0005339)3.36585506
35Dicarboxylic aciduria (HP:0003215)3.24592679
36Abnormality of dicarboxylic acid metabolism (HP:0010995)3.24592679
37Abnormality of pyrimidine metabolism (HP:0004353)3.23674429
38Nephritis (HP:0000123)3.20166600
39Abnormality of serum amino acid levels (HP:0003112)3.16537712
40Hyperbilirubinemia (HP:0002904)3.13535690
41Abnormality of nucleobase metabolism (HP:0010932)3.08780522
42Delayed CNS myelination (HP:0002188)3.08764154
43Metabolic acidosis (HP:0001942)3.07416426
44Abnormality of purine metabolism (HP:0004352)3.01333569
45Gout (HP:0001997)2.88496634
46Lethargy (HP:0001254)2.87140026
47Skin nodule (HP:0200036)2.81698315
48Gingival bleeding (HP:0000225)2.78657898
49Generalized aminoaciduria (HP:0002909)2.73923846
50Hepatocellular carcinoma (HP:0001402)2.73116455
51Cerebral edema (HP:0002181)2.72692145
52Steatorrhea (HP:0002570)2.72314598
53Hypoglycemic seizures (HP:0002173)2.67771574
54Myocardial infarction (HP:0001658)2.66014236
55Osteomalacia (HP:0002749)2.61317645
56Spontaneous abortion (HP:0005268)2.56593787
57Vascular calcification (HP:0004934)2.52486230
58Abnormal gallbladder morphology (HP:0012437)2.41741183
59Systemic lupus erythematosus (HP:0002725)2.39952186
60Proximal tubulopathy (HP:0000114)2.39357564
61Hyperinsulinemic hypoglycemia (HP:0000825)2.38591909
62Vomiting (HP:0002013)2.36690609
63Cholelithiasis (HP:0001081)2.36267572
64Hypochromic microcytic anemia (HP:0004840)2.36172028
65Renal cortical cysts (HP:0000803)2.34702843
66Acanthocytosis (HP:0001927)2.29646401
67Abnormality of proline metabolism (HP:0010907)2.29248162
68Hydroxyprolinuria (HP:0003080)2.29248162
69Protrusio acetabuli (HP:0003179)2.28695746
70Malnutrition (HP:0004395)2.28495504
71Chronic hepatic failure (HP:0100626)2.27738567
72Pancreatitis (HP:0001733)2.27166748
73Irritability (HP:0000737)2.26546445
74Spastic diplegia (HP:0001264)2.25712893
75Cardiovascular calcification (HP:0011915)2.25266148
76Late onset (HP:0003584)2.21968884
77Myoglobinuria (HP:0002913)2.21848337
78Neonatal onset (HP:0003623)2.21581271
79Hyperuricemia (HP:0002149)2.19755225
80Increased purine levels (HP:0004368)2.19755225
81Sensorimotor neuropathy (HP:0007141)2.18244426
82Abnormal delivery (HP:0001787)2.17613464
83Enlarged kidneys (HP:0000105)2.17409148
84Arthropathy (HP:0003040)2.16398826
85Hyperphosphaturia (HP:0003109)2.13874955
86Brushfield spots (HP:0001088)2.12604997
87Facial shape deformation (HP:0011334)2.12087874
88Potter facies (HP:0002009)2.12087874
89Cholecystitis (HP:0001082)2.10689459
90Abnormal gallbladder physiology (HP:0012438)2.10689459
91Abnormality of urine glucose concentration (HP:0011016)2.08328820
92Glycosuria (HP:0003076)2.08328820
93Recurrent gram-negative bacterial infections (HP:0005420)2.07811347
94Hyperglycemia (HP:0003074)2.07264553
95Esophageal varix (HP:0002040)2.04946940
96Mitral stenosis (HP:0001718)2.03107771
97Alkalosis (HP:0001948)2.03031331
98Abnormal cartilage morphology (HP:0002763)2.00572987
99Glomerulonephritis (HP:0000099)1.99007141
100Hemorrhage of the eye (HP:0011885)1.97100937
101Nausea (HP:0002018)1.96428624
102Abnormal biliary tract physiology (HP:0012439)1.95227160
103Bile duct proliferation (HP:0001408)1.95227160
104Abnormal tarsal ossification (HP:0008369)1.94953902
105Amyloidosis (HP:0011034)1.94440785
106Opisthotonus (HP:0002179)1.93788965
107Abnormality of the gallbladder (HP:0005264)1.92873228
108Hypertriglyceridemia (HP:0002155)1.92828294
109Rickets (HP:0002748)1.89650891
110Abnormality of carpal bone ossification (HP:0006257)1.89293529
111Elevated hepatic transaminases (HP:0002910)1.84579077
112Retinal atrophy (HP:0001105)1.84134651
113Symptomatic seizures (HP:0011145)1.83179303
114Increased serum pyruvate (HP:0003542)1.81315457
115Abnormal enzyme/coenzyme activity (HP:0012379)1.80730495
116Thrombophlebitis (HP:0004418)1.80479931
117Abnormality of vitamin metabolism (HP:0100508)1.80108071
118Hypophosphatemic rickets (HP:0004912)1.79796055
119Abnormal urine phosphate concentration (HP:0012599)1.79244500
120Type II lissencephaly (HP:0007260)1.79069825
121Broad alveolar ridges (HP:0000187)1.77141607
122Menorrhagia (HP:0000132)1.76934489
123Bifid scrotum (HP:0000048)1.75864240
124Calf muscle hypertrophy (HP:0008981)1.67982044
125Fair hair (HP:0002286)1.57133519
126Flat acetabular roof (HP:0003180)1.57009932
127Cervical subluxation (HP:0003308)1.54327124
128Broad palm (HP:0001169)1.53378920
129Joint swelling (HP:0001386)1.52256103
130Hepatoblastoma (HP:0002884)1.48106507
131Elevated alkaline phosphatase (HP:0003155)1.46373009
132Abnormal hand bone ossification (HP:0010660)1.44140578
133Retinal dysplasia (HP:0007973)1.44038635
134Pigmentary retinal degeneration (HP:0001146)1.43580204
135Abnormality of the vitreous humor (HP:0004327)1.41944664

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.25125431
2SIK13.98315655
3FGFR43.54060386
4ERN13.47461104
5INSRR3.34336012
6MST1R2.71004730
7TRIB32.34361073
8PDGFRA2.26965606
9TAOK32.20226668
10PKN22.17601247
11ERBB42.11492738
12CAMKK21.91503697
13MAP3K131.88547125
14PDK41.88393088
15PDK31.88393088
16LATS11.87714817
17MAP2K41.78013530
18PINK11.75751549
19PIK3CG1.71081386
20FRK1.69683638
21FLT31.69298816
22MAPK111.61032942
23CDK191.57055020
24DDR21.55679437
25PRKAA21.45079733
26CAMK1D1.44445822
27BRSK21.44120794
28STK38L1.43213848
29PTK61.40652621
30NTRK11.39126635
31TIE11.38559381
32MAP3K71.30114913
33NEK91.28956485
34NLK1.26281899
35TYK21.25764517
36BRD41.22158414
37AKT31.15192717
38TYRO31.15088976
39CDC42BPA1.14618617
40PDK21.14397511
41PIK3CA1.14288897
42ABL21.13485692
43BCR1.13398682
44MET1.13244669
45SCYL21.12999983
46FGFR21.12612661
47NTRK31.11595213
48PBK1.11031371
49JAK21.05863366
50MAP3K31.04998128
51WNK41.02114834
52MARK11.02111448
53MAP2K31.01605071
54KDR0.99022408
55RIPK10.98739296
56PRKAA10.94169356
57JAK10.93947758
58NTRK20.93516109
59DAPK20.93244864
60EPHA40.93235707
61LMTK20.91739857
62IRAK30.91220444
63EPHB10.90263190
64TTN0.87435036
65MARK20.82970296
66MYLK0.82552283
67TGFBR20.82138154
68OBSCN0.80509131
69FER0.79763115
70CSNK1A1L0.79424184
71CAMK1G0.78098309
72PRKACG0.77627450
73SGK30.76455207
74SRPK10.75515950
75CSNK1G10.74203798
76MAPK120.73632183
77TBK10.73608728
78PRKG10.72471559
79PRKCG0.71673613
80MAPK40.71498878
81EEF2K0.71189676
82PDGFRB0.70893976
83DYRK1A0.70258027
84ERBB30.69376524
85ERBB20.67931913
86PDPK10.67833501
87EPHB20.66596587
88CAMK10.66335355
89STK390.66224955
90WNK10.65401285
91CDK90.64846470
92GSK3A0.64070993
93SGK20.63780708
94MAP3K140.63041834
95WNK30.62630777
96NEK60.62289654
97EPHA30.62070080
98CDK60.61815856
99MAPKAPK30.61492069
100KSR20.61090508
101EIF2AK30.59917320
102PRKACB0.59664687
103PRKCZ0.59504450
104PHKG20.59164883
105PHKG10.59164883
106GRK60.59010100
107CSNK1G30.58933952
108CAMK2G0.58019920
109FGFR10.56897534
110SGK2230.56004040
111SGK4940.56004040
112MAP3K100.54352882
113FGFR30.53655325
114PRKACA0.52884404
115MAPK100.52058298
116MAPK150.51667530
117PTK20.51368642
118PRKCE0.51162653
119MAP2K10.50667264
120OXSR10.50575122
121RPS6KA30.50407710
122PAK30.49409093
123MAPK70.48840657
124MAP2K60.48795332
125STK30.48507807
126PDK10.48133750
127NEK10.47838062
128DYRK1B0.46747584
129UHMK10.46671264
130CSK0.46577232
131CASK0.46335394
132SRC0.45834083
133MAP3K50.44982597
134CSNK1D0.44397910
135CSNK1G20.43832054
136MAP3K20.43237784
137RET0.40536825
138MAP3K60.40032573
139IGF1R0.39984927
140PRKCQ0.36875912
141GRK10.36639803
142PKN10.35069116
143PRKD10.34849678
144MTOR0.34389360
145MAP3K110.33851087
146ICK0.33811336
147IKBKE0.30062329
148IRAK10.29482998
149MAP2K20.28991386
150CAMK40.27728583
151STK380.26262601
152CDK40.25447896

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.04313599
2Nitrogen metabolism_Homo sapiens_hsa009103.29760553
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.16989599
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.14074214
5Fatty acid degradation_Homo sapiens_hsa000712.87352647
6Arginine biosynthesis_Homo sapiens_hsa002202.79631243
7Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.78624128
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.70662769
9Tryptophan metabolism_Homo sapiens_hsa003802.67950664
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.61661512
11Propanoate metabolism_Homo sapiens_hsa006402.50264429
12Butanoate metabolism_Homo sapiens_hsa006502.37249151
13Complement and coagulation cascades_Homo sapiens_hsa046102.35197616
14Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.34917288
15Pentose and glucuronate interconversions_Homo sapiens_hsa000402.18557782
16Peroxisome_Homo sapiens_hsa041462.17293842
17Fatty acid metabolism_Homo sapiens_hsa012122.17279820
18PPAR signaling pathway_Homo sapiens_hsa033202.10763201
19Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.00761956
202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.93246316
21beta-Alanine metabolism_Homo sapiens_hsa004101.87846508
22Chemical carcinogenesis_Homo sapiens_hsa052041.78428614
23Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.77185113
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.76309023
25Histidine metabolism_Homo sapiens_hsa003401.75998675
26Steroid hormone biosynthesis_Homo sapiens_hsa001401.69999761
27Caffeine metabolism_Homo sapiens_hsa002321.67805086
28Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.64777304
29Pyruvate metabolism_Homo sapiens_hsa006201.64161221
30Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.58358986
31Drug metabolism - other enzymes_Homo sapiens_hsa009831.56496312
32Retinol metabolism_Homo sapiens_hsa008301.54903870
33Fatty acid elongation_Homo sapiens_hsa000621.52682286
34Phenylalanine metabolism_Homo sapiens_hsa003601.52255790
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.45424371
36Staphylococcus aureus infection_Homo sapiens_hsa051501.45300788
37Bile secretion_Homo sapiens_hsa049761.45067562
38Sulfur metabolism_Homo sapiens_hsa009201.43310485
39Selenocompound metabolism_Homo sapiens_hsa004501.43262180
40Carbon metabolism_Homo sapiens_hsa012001.38566142
41Starch and sucrose metabolism_Homo sapiens_hsa005001.36837180
42Tyrosine metabolism_Homo sapiens_hsa003501.35338366
43Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.25721671
44Fat digestion and absorption_Homo sapiens_hsa049751.24202101
45Cysteine and methionine metabolism_Homo sapiens_hsa002701.19568550
46ABC transporters_Homo sapiens_hsa020101.19455968
47Biosynthesis of amino acids_Homo sapiens_hsa012301.19335451
48Folate biosynthesis_Homo sapiens_hsa007901.12638573
49Maturity onset diabetes of the young_Homo sapiens_hsa049500.99320283
50Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.99163344
51Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.98462744
52Arginine and proline metabolism_Homo sapiens_hsa003300.97034227
53Cyanoamino acid metabolism_Homo sapiens_hsa004600.95971760
54Steroid biosynthesis_Homo sapiens_hsa001000.94788486
55Vitamin digestion and absorption_Homo sapiens_hsa049770.92624734
56Lysine degradation_Homo sapiens_hsa003100.89301249
57Other glycan degradation_Homo sapiens_hsa005110.88657585
58Glycerolipid metabolism_Homo sapiens_hsa005610.87722870
59Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.86124064
60Vitamin B6 metabolism_Homo sapiens_hsa007500.85741799
61Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.85699790
62Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.82381303
63Fatty acid biosynthesis_Homo sapiens_hsa000610.81382844
64Sulfur relay system_Homo sapiens_hsa041220.81067996
65Glutathione metabolism_Homo sapiens_hsa004800.71013915
66Pentose phosphate pathway_Homo sapiens_hsa000300.58899502
67One carbon pool by folate_Homo sapiens_hsa006700.50299409
68Metabolic pathways_Homo sapiens_hsa011000.49305643
69Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.45316269
70Adipocytokine signaling pathway_Homo sapiens_hsa049200.39969477
71Circadian rhythm_Homo sapiens_hsa047100.38574084
72Fructose and mannose metabolism_Homo sapiens_hsa000510.37192552
73Insulin resistance_Homo sapiens_hsa049310.36986110
74Galactose metabolism_Homo sapiens_hsa000520.34830392
75ECM-receptor interaction_Homo sapiens_hsa045120.34107749
76alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.31128689
77Glucagon signaling pathway_Homo sapiens_hsa049220.21440992
78Linoleic acid metabolism_Homo sapiens_hsa005910.21403368
79Glycerophospholipid metabolism_Homo sapiens_hsa005640.20524732
80Prion diseases_Homo sapiens_hsa050200.19077521
81AMPK signaling pathway_Homo sapiens_hsa041520.17726429
82Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.16267109
83Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.14289651
84Sphingolipid metabolism_Homo sapiens_hsa006000.09702411
85Insulin signaling pathway_Homo sapiens_hsa049100.02249480
86Parkinsons disease_Homo sapiens_hsa05012-0.2116925
87Hepatitis C_Homo sapiens_hsa05160-0.1868848
88Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923-0.1863058
89Type II diabetes mellitus_Homo sapiens_hsa04930-0.1683529
90Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1637197
91Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.1624057
92Oxidative phosphorylation_Homo sapiens_hsa00190-0.1609836
93Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1585129
94Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1573535
95Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.1561163
96Protein digestion and absorption_Homo sapiens_hsa04974-0.1491774
97Mineral absorption_Homo sapiens_hsa04978-0.1417604
98Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1242661
99Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1214989
100Regulation of autophagy_Homo sapiens_hsa04140-0.1140851
101Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563-0.1133331
102Dilated cardiomyopathy_Homo sapiens_hsa05414-0.1096513
103Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410-0.0975667
104Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0838029
105Renin-angiotensin system_Homo sapiens_hsa04614-0.0827682
106Inositol phosphate metabolism_Homo sapiens_hsa00562-0.0812542
107Serotonergic synapse_Homo sapiens_hsa04726-0.0737037
108Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0695606
109Ether lipid metabolism_Homo sapiens_hsa00565-0.0677033
110Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962-0.0638271
111Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0586486
112Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.0426634
113Cocaine addiction_Homo sapiens_hsa05030-0.0409030
114Pertussis_Homo sapiens_hsa05133-0.0128153
115Amoebiasis_Homo sapiens_hsa05146-0.0030596

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