ACAD8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the acyl-CoA dehydrogenase family of enzymes that catalyze the dehydrogenation of acyl-CoA derivatives in the metabolism of fatty acids or branch chained amino acids. The encoded protein is a mitochondrial enzyme that functions in catabolism of the branched-chain amino acid valine. Defects in this gene are the cause of isobutyryl-CoA dehydrogenase deficiency. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-methionine biosynthetic process from methylthioadenosine (GO:0019509)7.63732768
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.80193020
3L-phenylalanine catabolic process (GO:0006559)6.80193020
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.61859969
5L-phenylalanine metabolic process (GO:0006558)6.61859969
6amino acid salvage (GO:0043102)6.40661947
7L-methionine salvage (GO:0071267)6.40661947
8L-methionine biosynthetic process (GO:0071265)6.40661947
9aromatic amino acid family catabolic process (GO:0009074)6.02454844
10glyoxylate metabolic process (GO:0046487)5.60164249
11sulfur amino acid catabolic process (GO:0000098)5.48913932
12tryptophan catabolic process (GO:0006569)5.39747568
13indole-containing compound catabolic process (GO:0042436)5.39747568
14indolalkylamine catabolic process (GO:0046218)5.39747568
15kynurenine metabolic process (GO:0070189)5.36392525
16cysteine metabolic process (GO:0006534)5.31546345
17alpha-linolenic acid metabolic process (GO:0036109)5.25014824
18lysine metabolic process (GO:0006553)5.23175696
19lysine catabolic process (GO:0006554)5.23175696
20bile acid biosynthetic process (GO:0006699)5.19194479
21methionine biosynthetic process (GO:0009086)5.15898715
22tryptophan metabolic process (GO:0006568)5.15470133
23triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.12423065
24cellular ketone body metabolic process (GO:0046950)5.11203437
25CENP-A containing nucleosome assembly (GO:0034080)5.06944063
26serine family amino acid catabolic process (GO:0009071)4.91979990
27fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.86031728
28chromatin remodeling at centromere (GO:0031055)4.85778168
29amino-acid betaine metabolic process (GO:0006577)4.83716985
30negative regulation of translation, ncRNA-mediated (GO:0040033)4.74404770
31regulation of translation, ncRNA-mediated (GO:0045974)4.74404770
32negative regulation of translation involved in gene silencing by miRNA (GO:0035278)4.74404770
33homocysteine metabolic process (GO:0050667)4.72770240
34methionine metabolic process (GO:0006555)4.70099989
35urea cycle (GO:0000050)4.64055478
36urea metabolic process (GO:0019627)4.64055478
37sulfur amino acid biosynthetic process (GO:0000097)4.63621154
38ethanol oxidation (GO:0006069)4.57305421
39regulation of translation in response to stress (GO:0043555)4.56625119
40peptidyl-glutamic acid carboxylation (GO:0017187)4.54986561
41protein carboxylation (GO:0018214)4.54986561
42* alpha-amino acid catabolic process (GO:1901606)4.51012640
43aromatic amino acid family metabolic process (GO:0009072)4.47986690
44high-density lipoprotein particle remodeling (GO:0034375)4.47955060
45regulation of protein activation cascade (GO:2000257)4.47738535
46glycine metabolic process (GO:0006544)4.46811269
47complement activation, alternative pathway (GO:0006957)4.43764725
48ketone body metabolic process (GO:1902224)4.41353537
49regulation of sister chromatid cohesion (GO:0007063)4.40045422
50bile acid metabolic process (GO:0008206)4.37651128
51negative regulation of fibrinolysis (GO:0051918)4.36358407
52regulation of triglyceride catabolic process (GO:0010896)4.36066886
53nitrogen cycle metabolic process (GO:0071941)4.36021870
54serine family amino acid metabolic process (GO:0009069)4.33627784
55* cellular amino acid catabolic process (GO:0009063)4.33387418
56regulation of nuclear cell cycle DNA replication (GO:0033262)4.30124324
57serine family amino acid biosynthetic process (GO:0009070)4.29223773
58detection of calcium ion (GO:0005513)4.27802312
59fatty acid beta-oxidation (GO:0006635)4.24546816
60regulation of complement activation (GO:0030449)4.23385463
61* branched-chain amino acid catabolic process (GO:0009083)4.21360548
62* valine metabolic process (GO:0006573)4.21139842
63short-chain fatty acid metabolic process (GO:0046459)4.18964281
64coenzyme catabolic process (GO:0009109)4.15803221
65cellular glucuronidation (GO:0052695)4.12928257
66tyrosine metabolic process (GO:0006570)4.12322909
67fatty acid oxidation (GO:0019395)4.12152037
68aspartate family amino acid biosynthetic process (GO:0009067)4.10501881
69regulation of fibrinolysis (GO:0051917)4.09226381
70aspartate family amino acid catabolic process (GO:0009068)4.06252025
71lipid oxidation (GO:0034440)4.04598510
72acetyl-CoA metabolic process (GO:0006084)4.04418630
732-oxoglutarate metabolic process (GO:0006103)4.03273896
74acylglycerol homeostasis (GO:0055090)3.99359170
75triglyceride homeostasis (GO:0070328)3.99359170
76* carboxylic acid catabolic process (GO:0046395)3.97828838
77* organic acid catabolic process (GO:0016054)3.97828838
78fatty acid catabolic process (GO:0009062)3.97529268
79reverse cholesterol transport (GO:0043691)3.96440349
80protein-lipid complex remodeling (GO:0034368)3.95454638
81macromolecular complex remodeling (GO:0034367)3.95454638
82plasma lipoprotein particle remodeling (GO:0034369)3.95454638
83monocarboxylic acid catabolic process (GO:0072329)3.89465164
84* branched-chain amino acid metabolic process (GO:0009081)3.89070425
85carnitine metabolic process (GO:0009437)3.88706932
86histone exchange (GO:0043486)3.88526600
87cellular modified amino acid catabolic process (GO:0042219)3.87828089
88regulation of cholesterol esterification (GO:0010872)3.87156267
89aldehyde catabolic process (GO:0046185)3.87076777
90cellular biogenic amine catabolic process (GO:0042402)3.86858915
91amine catabolic process (GO:0009310)3.86858915
92indolalkylamine metabolic process (GO:0006586)3.86032595
93sulfur amino acid metabolic process (GO:0000096)3.85927832
94bile acid and bile salt transport (GO:0015721)3.80474067
95benzene-containing compound metabolic process (GO:0042537)3.78894133
96glutamate metabolic process (GO:0006536)3.78763286
97glucuronate metabolic process (GO:0019585)3.77314542
98uronic acid metabolic process (GO:0006063)3.77314542
99imidazole-containing compound metabolic process (GO:0052803)3.71541203
100establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.70068904
101mitochondrion transport along microtubule (GO:0047497)3.70068904
102DNA replication-independent nucleosome organization (GO:0034724)3.68575997
103DNA replication-independent nucleosome assembly (GO:0006336)3.68575997
104plasma lipoprotein particle clearance (GO:0034381)3.68388520
105pyrimidine nucleotide catabolic process (GO:0006244)3.67729840
106negative regulation of cholesterol transport (GO:0032375)3.67099011
107negative regulation of sterol transport (GO:0032372)3.67099011
108establishment of mitochondrion localization (GO:0051654)3.65557434
109iron-sulfur cluster assembly (GO:0016226)3.65335385
110metallo-sulfur cluster assembly (GO:0031163)3.65335385
111pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.63092220
112drug catabolic process (GO:0042737)3.60837886
113drug transmembrane transport (GO:0006855)3.57084992
114phospholipid efflux (GO:0033700)3.53838169
115urate metabolic process (GO:0046415)3.52325876
116ethanol metabolic process (GO:0006067)3.50259327
117N-terminal protein amino acid acetylation (GO:0006474)3.50234596
118RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.50086619
119tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.50086619
120ubiquinone metabolic process (GO:0006743)3.47232726
121drug metabolic process (GO:0017144)3.45149157
122ubiquinone biosynthetic process (GO:0006744)3.45086016
123establishment of integrated proviral latency (GO:0075713)3.44143002
124biotin metabolic process (GO:0006768)3.42907597
125mitotic sister chromatid cohesion (GO:0007064)3.42562194
126phospholipid homeostasis (GO:0055091)3.42227964
127* small molecule catabolic process (GO:0044282)3.39470984
128DNA integration (GO:0015074)3.39409427
129low-density lipoprotein particle remodeling (GO:0034374)3.38852378
130regulation of cholesterol homeostasis (GO:2000188)3.37605789
131L-serine metabolic process (GO:0006563)3.37149877
132positive regulation of triglyceride lipase activity (GO:0061365)3.36332824
133positive regulation of lipoprotein lipase activity (GO:0051006)3.36332824
134primary alcohol catabolic process (GO:0034310)3.35676618
135flavonoid metabolic process (GO:0009812)3.35313151
136positive regulation of fatty acid beta-oxidation (GO:0032000)3.33109304
137histone H4-K5 acetylation (GO:0043981)3.30740642
138histone H4-K8 acetylation (GO:0043982)3.30740642
139histone H4-K12 acetylation (GO:0043983)3.15319610
140fatty acid elongation (GO:0030497)3.13231280
141mitotic metaphase plate congression (GO:0007080)3.11866093
142DNA ligation (GO:0006266)3.07989719
143regulation of gene silencing by RNA (GO:0060966)3.04741428
144regulation of posttranscriptional gene silencing (GO:0060147)3.04741428
145regulation of gene silencing by miRNA (GO:0060964)3.04741428
146negative regulation of translational initiation (GO:0045947)3.03245319
147aspartate family amino acid metabolic process (GO:0009066)3.01980622
148telomere maintenance via semi-conservative replication (GO:0032201)2.97330722
149seminiferous tubule development (GO:0072520)2.94324231
150neuronal action potential (GO:0019228)2.93146320
151positive regulation of microtubule polymerization (GO:0031116)2.91905646
152quinone biosynthetic process (GO:1901663)2.89858343
153establishment of viral latency (GO:0019043)2.89815510
154histone arginine methylation (GO:0034969)2.89200067
155negative regulation of phosphoprotein phosphatase activity (GO:0032515)2.87471772
156folic acid-containing compound biosynthetic process (GO:0009396)2.84976096
157telomere maintenance via telomere lengthening (GO:0010833)2.82575105
158maturation of 5.8S rRNA (GO:0000460)2.79715001
159pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.72699880
160postsynaptic membrane organization (GO:0001941)2.70571722
161DNA replication-dependent nucleosome assembly (GO:0006335)2.69237572
162DNA replication-dependent nucleosome organization (GO:0034723)2.69237572
163regulation of centriole replication (GO:0046599)2.68005348
164microtubule nucleation (GO:0007020)2.63455785
165cardiolipin metabolic process (GO:0032048)2.62302941
166positive regulation of SMAD protein import into nucleus (GO:0060391)2.58232758
167signal peptide processing (GO:0006465)2.58020351
168phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.54795806
169germ cell migration (GO:0008354)2.54153798
170DNA strand elongation involved in DNA replication (GO:0006271)2.54053807
171cellular response to cholesterol (GO:0071397)2.53752939
172DNA catabolic process, exonucleolytic (GO:0000738)2.51829137
173nucleotide-excision repair, DNA gap filling (GO:0006297)2.49881490
174purine nucleobase biosynthetic process (GO:0009113)2.49636832
175regulation of telomere maintenance via telomerase (GO:0032210)2.49104642
176peptidyl-cysteine modification (GO:0018198)2.48974393
177mitotic chromosome condensation (GO:0007076)2.48335007
178IMP biosynthetic process (GO:0006188)2.46623745
179adaptation of signaling pathway (GO:0023058)2.46576900
180C4-dicarboxylate transport (GO:0015740)2.46325202
181oxidative phosphorylation (GO:0006119)2.46156225
182negative regulation of DNA-dependent DNA replication (GO:2000104)2.45382704
183isoprenoid biosynthetic process (GO:0008299)2.42856801
184secondary heart field specification (GO:0003139)2.39979846
185heart field specification (GO:0003128)2.39979846
186chromatin assembly or disassembly (GO:0006333)2.39700846
187negative regulation of telomere maintenance (GO:0032205)2.36293820

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse7.57264257
2PPARA_22158963_ChIP-Seq_LIVER_Mouse6.68235553
3* PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.61041477
4EGR1_23403033_ChIP-Seq_LIVER_Mouse5.78677180
5LXR_22158963_ChIP-Seq_LIVER_Mouse5.77700074
6E2F7_22180533_ChIP-Seq_HELA_Human5.45064565
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.75683312
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.71630011
9TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.44759694
10ELF1_17652178_ChIP-ChIP_JURKAT_Human4.08454748
11CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.67791678
12NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.44075719
13TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.07167208
14IRF1_19129219_ChIP-ChIP_H3396_Human2.76160630
15* NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.62259954
16MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.50299930
17HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.47892120
18GABP_17652178_ChIP-ChIP_JURKAT_Human2.37465247
19HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.37219821
20EST1_17652178_ChIP-ChIP_JURKAT_Human2.32304721
21ZNF274_21170338_ChIP-Seq_K562_Hela2.27706661
22TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.24147981
23EZH2_22144423_ChIP-Seq_EOC_Human2.20798650
24MYC_18555785_ChIP-Seq_MESCs_Mouse2.19649023
25POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.19402041
26CLOCK_20551151_ChIP-Seq_293T_Human2.17784311
27IGF1R_20145208_ChIP-Seq_DFB_Human2.17640173
28YY1_21170310_ChIP-Seq_MESCs_Mouse2.07652574
29GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.05043731
30ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.8840597
31DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.97042924
32TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.94562563
33HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.83631700
34SOX2_18555785_ChIP-Seq_MESCs_Mouse1.81426116
35E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.81305192
36GATA1_22025678_ChIP-Seq_K562_Human1.79458794
37E2F4_17652178_ChIP-ChIP_JURKAT_Human1.66128255
38ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.63569240
39STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.59554992
40PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.55241686
41NANOG_18555785_ChIP-Seq_MESCs_Mouse1.54142480
42* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.49388373
43ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.47992204
44THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.42909204
45HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.42068713
46PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.40170041
47TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.40069568
48RARG_19884340_ChIP-ChIP_MEFs_Mouse1.38871654
49ETS1_20019798_ChIP-Seq_JURKAT_Human1.38086948
50* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.36559971
51MYC_19030024_ChIP-ChIP_MESCs_Mouse1.34850351
52* FOXP3_21729870_ChIP-Seq_TREG_Human1.34665053
53CIITA_25753668_ChIP-Seq_RAJI_Human1.33112786
54NANOG_16153702_ChIP-ChIP_HESCs_Human1.32515090
55GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.31882597
56FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.31692940
57YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.30748470
58HNF4A_19822575_ChIP-Seq_HepG2_Human1.28302860
59CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.27518516
60FOXA2_19822575_ChIP-Seq_HepG2_Human1.27071640
61FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.26725567
62CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.26041581
63SOX2_27498859_Chip-Seq_STOMACH_Mouse1.24984103
64NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.24815014
65POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.24395008
66MYCN_18555785_ChIP-Seq_MESCs_Mouse1.23710715
67GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.20482187
68SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.19487894
69VDR_22108803_ChIP-Seq_LS180_Human1.19440937
70MYC_19079543_ChIP-ChIP_MESCs_Mouse1.17521458
71NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.16798099
72GABP_19822575_ChIP-Seq_HepG2_Human1.16536778
73LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.13807647
74ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.13401891
75VDR_23849224_ChIP-Seq_CD4+_Human1.12955172
76POU5F1_16153702_ChIP-ChIP_HESCs_Human1.11598593
77HTT_18923047_ChIP-ChIP_STHdh_Human1.11427796
78RXRA_24833708_ChIP-Seq_LIVER_Mouse1.10477380
79NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.09914765
80PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.09863123
81CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.07994068
82REST_21632747_ChIP-Seq_MESCs_Mouse1.07612598
83NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.05016543
84SOX2_16153702_ChIP-ChIP_HESCs_Human1.04844335
85* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.02568172
86E2F1_21310950_ChIP-Seq_MCF-7_Human1.01179823
87POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.00354073
88STAT3_1855785_ChIP-Seq_MESCs_Mouse0.99803419
89ZNF263_19887448_ChIP-Seq_K562_Human0.99038680
90* OCT4_20526341_ChIP-Seq_ESCs_Human0.95344353
91GATA4_25053715_ChIP-Seq_YYC3_Human0.92733762
92TAF15_26573619_Chip-Seq_HEK293_Human0.92697755
93PADI4_21655091_ChIP-ChIP_MCF-7_Human0.91154217
94POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.90895162
95ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.90740755
96* SRF_21415370_ChIP-Seq_HL-1_Mouse0.90067477
97PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.89875918
98ESR2_21235772_ChIP-Seq_MCF-7_Human0.88110525
99ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.87945838
100KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.87913256
101KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.83358795
102KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.83358795
103KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.83358795
104ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.83208808
105KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.82445142
106HOXB4_20404135_ChIP-ChIP_EML_Mouse0.81397068
107* CREB1_15753290_ChIP-ChIP_HEK293T_Human0.80935073
108KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.80786390
109SALL4_18804426_ChIP-ChIP_XEN_Mouse0.80465857
110SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.80418770
111SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.79993765
112TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.79898526
113NELFA_20434984_ChIP-Seq_ESCs_Mouse0.79056248
114FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.78623039
115BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.78169314
116PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.77108036
117STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.77084713
118RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.76699865
119GATA3_21867929_ChIP-Seq_CD8_Mouse0.75328367
120RAD21_21589869_ChIP-Seq_MESCs_Mouse0.74839443
121FOXA1_21572438_ChIP-Seq_LNCaP_Human0.74732307
122CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.73548007
123AR_20517297_ChIP-Seq_VCAP_Human0.73304001
124KDM5A_27292631_Chip-Seq_BREAST_Human0.72827863
125ESR1_21235772_ChIP-Seq_MCF-7_Human0.72656179
126ERA_21632823_ChIP-Seq_H3396_Human0.72610294
127XRN2_22483619_ChIP-Seq_HELA_Human0.72497231
128FLI1_27457419_Chip-Seq_LIVER_Mouse0.71795040
129AUTS2_25519132_ChIP-Seq_293T-REX_Human0.71319490
130EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.71312291
131E2F1_17053090_ChIP-ChIP_MCF-7_Human0.70748276
132JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.69976475
133PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.69920962
134E2F1_18555785_ChIP-Seq_MESCs_Mouse0.69906773
135FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.69460236
136AR_21909140_ChIP-Seq_LNCAP_Human0.68931913
137RARA_24833708_ChIP-Seq_LIVER_Mouse0.68200063
138ESR1_15608294_ChIP-ChIP_MCF-7_Human0.66287707
139AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.65383119
140FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.62898408
141PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.62597564
142CEBPB_22108803_ChIP-Seq_LS180_Human0.59149995
143* SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.58960523
144* RARB_24833708_ChIP-Seq_LIVER_Mouse0.58518583
145BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.57910269
146EGR1_19032775_ChIP-ChIP_M12_Human0.56997340
147KAP1_22055183_ChIP-Seq_ESCs_Mouse0.56494532
148GATA3_24758297_ChIP-Seq_MCF-7_Human0.55977277
149IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.55478514
150SOX17_20123909_ChIP-Seq_XEN_Mouse0.54465793
151GATA6_25053715_ChIP-Seq_YYC3_Human0.54451805
152NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.54274141
153NRF2_20460467_ChIP-Seq_MEFs_Mouse0.54274141
154LXR_22292898_ChIP-Seq_THP-1_Human0.53878508
155GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.53660999
156CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.53446925
157* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.53097282
158PPAR_26484153_Chip-Seq_NCI-H1993_Human0.52480120
159ERG_20517297_ChIP-Seq_VCAP_Human0.51712868
160SOX2_20726797_ChIP-Seq_SW620_Human0.51442389
161TBX20_22328084_ChIP-Seq_HEART_Mouse0.49602481
162TBX20_22080862_ChIP-Seq_HEART_Mouse0.49602481
163SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.49414611
164FOXA1_25552417_ChIP-Seq_VCAP_Human0.49319436
165RACK7_27058665_Chip-Seq_MCF-7_Human0.49168249
166CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.49008543
167TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.48928856
168SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.48315202
169* TBX5_21415370_ChIP-Seq_HL-1_Mouse0.48198997
170PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.47402342
171P53_21459846_ChIP-Seq_SAOS-2_Human0.47056112
172MYC_19915707_ChIP-ChIP_AK7_Human0.46936712
173* MYC_18358816_ChIP-ChIP_MESCs_Mouse0.46617798
174OCT4_18692474_ChIP-Seq_MEFs_Mouse0.46533284
175TAF2_19829295_ChIP-Seq_ESCs_Human0.46141569
176BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.45952690
177FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.45655487
178BCOR_27268052_Chip-Seq_Bcells_Human0.44466513
179PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.43917564

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.58275162
2MP0005360_urolithiasis6.95945430
3MP0005085_abnormal_gallbladder_physiolo5.76400166
4MP0005365_abnormal_bile_salt5.75909736
5MP0008875_abnormal_xenobiotic_pharmacok5.03091407
6MP0003806_abnormal_nucleotide_metabolis4.59819487
7MP0008877_abnormal_DNA_methylation4.07965387
8MP0002736_abnormal_nociception_after3.39488768
9MP0003252_abnormal_bile_duct3.33898963
10MP0010329_abnormal_lipoprotein_level3.31253724
11MP0005332_abnormal_amino_acid3.24601195
12MP0001968_abnormal_touch/_nociception3.20006311
13MP0009840_abnormal_foam_cell3.12883793
14MP0001188_hyperpigmentation2.86837207
15MP0009379_abnormal_foot_pigmentation2.83575633
16MP0008058_abnormal_DNA_repair2.83284451
17MP0003195_calcinosis2.74169636
18MP0005083_abnormal_biliary_tract2.69958012
19MP0001666_abnormal_nutrient_absorption2.64378998
20MP0003191_abnormal_cellular_cholesterol2.59223237
21MP0004019_abnormal_vitamin_homeostasis2.48993894
22MP0000751_myopathy2.38659160
23MP0001529_abnormal_vocalization2.18635731
24MP0002118_abnormal_lipid_homeostasis2.16399463
25MP0000609_abnormal_liver_physiology2.01792388
26MP0005319_abnormal_enzyme/_coenzyme1.94428629
27MP0001764_abnormal_homeostasis1.87230707
28MP0004145_abnormal_muscle_electrophysio1.83337274
29MP0001545_abnormal_hematopoietic_system1.79177306
30MP0005397_hematopoietic_system_phenotyp1.79177306
31MP0002638_abnormal_pupillary_reflex1.79105365
32MP0009643_abnormal_urine_homeostasis1.76626028
33MP0005584_abnormal_enzyme/coenzyme_acti1.74311677
34MP0004147_increased_porphyrin_level1.72526273
35MP0003186_abnormal_redox_activity1.67900127
36MP0006292_abnormal_olfactory_placode1.67404651
37MP0005646_abnormal_pituitary_gland1.66895537
38MP0002735_abnormal_chemical_nociception1.64448163
39MP0003868_abnormal_feces_composition1.62320394
40MP0001486_abnormal_startle_reflex1.58252659
41MP0006036_abnormal_mitochondrial_physio1.56279674
42MP0006276_abnormal_autonomic_nervous1.56117455
43MP0005670_abnormal_white_adipose1.50846475
44MP0009046_muscle_twitch1.49932376
45MP0003880_abnormal_central_pattern1.44880125
46MP0004185_abnormal_adipocyte_glucose1.43862130
47MP0009697_abnormal_copulation1.42524460
48MP0002138_abnormal_hepatobiliary_system1.42493354
49MP0004043_abnormal_pH_regulation1.35355923
50MP0002837_dystrophic_cardiac_calcinosis1.34816670
51MP0002272_abnormal_nervous_system1.31278066
52MP0005645_abnormal_hypothalamus_physiol1.30887253
53MP0003787_abnormal_imprinting1.30625543
54MP0004130_abnormal_muscle_cell1.29948551
55MP0003635_abnormal_synaptic_transmissio1.29269224
56MP0009745_abnormal_behavioral_response1.27379055
57MP0003828_pulmonary_edema1.25932631
58MP0002733_abnormal_thermal_nociception1.25241094
59MP0001986_abnormal_taste_sensitivity1.24490816
60MP0005636_abnormal_mineral_homeostasis1.23205276
61MP0003890_abnormal_embryonic-extraembry1.22991392
62MP0002734_abnormal_mechanical_nocicepti1.22648189
63MP0005451_abnormal_body_composition1.21778537
64MP0001485_abnormal_pinna_reflex1.21548790
65MP0005167_abnormal_blood-brain_barrier1.20280743
66MP0005551_abnormal_eye_electrophysiolog1.14836590
67MP0006072_abnormal_retinal_apoptosis1.13850893
68MP0003567_abnormal_fetal_cardiomyocyte1.13036485
69MP0000598_abnormal_liver_morphology1.12525492
70MP0002572_abnormal_emotion/affect_behav1.12512650
71MP0003011_delayed_dark_adaptation1.12432121
72MP0003941_abnormal_skin_development1.08136612
73MP0001984_abnormal_olfaction1.06592907
74MP0002063_abnormal_learning/memory/cond1.03877248
75MP0001756_abnormal_urination1.03065721
76MP0004859_abnormal_synaptic_plasticity1.01997393
77MP0010094_abnormal_chromosome_stability1.01941877
78MP0002064_seizures0.99130310
79MP0009764_decreased_sensitivity_to0.97451363
80MP0001970_abnormal_pain_threshold0.97444921
81MP0000516_abnormal_urinary_system0.97307167
82MP0005367_renal/urinary_system_phenotyp0.97307167
83MP0006035_abnormal_mitochondrial_morpho0.96965065
84MP0002106_abnormal_muscle_physiology0.96179610
85MP0000604_amyloidosis0.95320885
86MP0002971_abnormal_brown_adipose0.95229810
87MP0003136_yellow_coat_color0.94221183
88MP0005058_abnormal_lysosome_morphology0.93879976
89MP0008569_lethality_at_weaning0.92415619
90MP0003656_abnormal_erythrocyte_physiolo0.91648357
91MP0005376_homeostasis/metabolism_phenot0.89946197
92MP0009703_decreased_birth_body0.89911633
93MP0010368_abnormal_lymphatic_system0.89871290
94MP0003693_abnormal_embryo_hatching0.89852577
95MP0009763_increased_sensitivity_to0.89644535
96MP0005666_abnormal_adipose_tissue0.88501101
97MP0001346_abnormal_lacrimal_gland0.88461606
98MP0003119_abnormal_digestive_system0.87935071
99MP0002396_abnormal_hematopoietic_system0.87841088
100MP0005647_abnormal_sex_gland0.87322691
101MP0002078_abnormal_glucose_homeostasis0.86837040
102MP0005266_abnormal_metabolism0.85949376
103MP0009642_abnormal_blood_homeostasis0.85720541
104MP0008995_early_reproductive_senescence0.84245846
105MP0005408_hypopigmentation0.84158098
106MP0005535_abnormal_body_temperature0.83773325
107MP0001661_extended_life_span0.83581790
108MP0002067_abnormal_sensory_capabilities0.82350971
109MP0003329_amyloid_beta_deposits0.81538814
110MP0005220_abnormal_exocrine_pancreas0.80890087
111MP0005499_abnormal_olfactory_system0.80387912
112MP0005394_taste/olfaction_phenotype0.80387912
113MP0000750_abnormal_muscle_regeneration0.80087886
114MP0001177_atelectasis0.79697935
115MP0008469_abnormal_protein_level0.79546599
116MP0002876_abnormal_thyroid_physiology0.79177788
117MP0003878_abnormal_ear_physiology0.78310519
118MP0005377_hearing/vestibular/ear_phenot0.78310519
119MP0005330_cardiomyopathy0.78274651
120MP0003690_abnormal_glial_cell0.78063732
121MP0003698_abnormal_male_reproductive0.77731103
122MP0004924_abnormal_behavior0.76250712
123MP0005386_behavior/neurological_phenoty0.76250712
124MP0005334_abnormal_fat_pad0.76067152
125MP0003111_abnormal_nucleus_morphology0.75103843
126MP0003121_genomic_imprinting0.74674198
127MP0003705_abnormal_hypodermis_morpholog0.74202758
128MP0005369_muscle_phenotype0.72121031
129MP0005423_abnormal_somatic_nervous0.72051843
130MP0002332_abnormal_exercise_endurance0.71792013
131MP0002210_abnormal_sex_determination0.71726383
132MP0002254_reproductive_system_inflammat0.71287157
133MP0000647_abnormal_sebaceous_gland0.70402033
134MP0001501_abnormal_sleep_pattern0.70320032
135MP0002557_abnormal_social/conspecific_i0.69296176
136MP0002229_neurodegeneration0.68658802
137MP0002277_abnormal_respiratory_mucosa0.68542444
138MP0004215_abnormal_myocardial_fiber0.68412717
139MP0003646_muscle_fatigue0.68394281
140MP0001929_abnormal_gametogenesis0.67983370
141MP0003221_abnormal_cardiomyocyte_apopto0.67628698
142MP0002136_abnormal_kidney_physiology0.66925706
143MP0009765_abnormal_xenobiotic_induced0.64629792
144MP0003638_abnormal_response/metabolism_0.63228013
145MP0005084_abnormal_gallbladder_morpholo0.63029615
146MP0001765_abnormal_ion_homeostasis0.61655813
147MP0000230_abnormal_systemic_arterial0.61253422
148MP0002796_impaired_skin_barrier0.60983924
149MP0002269_muscular_atrophy0.58175428
150MP0004036_abnormal_muscle_relaxation0.56701456
151MP0009053_abnormal_anal_canal0.56579654
152MP0005448_abnormal_energy_balance0.50907794
153MP0003953_abnormal_hormone_level0.49441161
154MP0003718_maternal_effect0.49170186
155MP0000747_muscle_weakness0.44484978
156MP0005395_other_phenotype0.44355710
157MP0000749_muscle_degeneration0.44330152
158MP0005166_decreased_susceptibility_to0.42033433
159MP0002970_abnormal_white_adipose0.41639235
160MP0008004_abnormal_stomach_pH0.41628685
161MP0005165_increased_susceptibility_to0.41451796
162MP0006138_congestive_heart_failure0.40175306
163MP0008872_abnormal_physiological_respon0.39236599
164MP0008873_increased_physiological_sensi0.39218417
165MP0004084_abnormal_cardiac_muscle0.39191465
166MP0004264_abnormal_extraembryonic_tissu0.38336043
167MP0005375_adipose_tissue_phenotype0.38177405
168MP0003959_abnormal_lean_body0.36223460
169MP0000639_abnormal_adrenal_gland0.36089443
170MP0009115_abnormal_fat_cell0.35821315
171MP0001853_heart_inflammation0.34195187
172MP0003724_increased_susceptibility_to0.33290561
173MP0004782_abnormal_surfactant_physiolog0.33287736
174MP0009672_abnormal_birth_weight0.32405182
175MP0000249_abnormal_blood_vessel0.32348454
176MP0002822_catalepsy0.31883997
177MP0004087_abnormal_muscle_fiber0.31512830
178MP0001544_abnormal_cardiovascular_syste0.29706607

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)6.21872201
2Intrahepatic cholestasis (HP:0001406)6.01677227
3Focal motor seizures (HP:0011153)5.71774932
4Deep venous thrombosis (HP:0002625)5.48431537
5Abnormality of monocarboxylic acid metabolism (HP:0010996)5.48028767
6Xanthomatosis (HP:0000991)5.32847333
7Hyperglycinuria (HP:0003108)5.13657752
8Hypobetalipoproteinemia (HP:0003563)4.98822120
9Hyperglycinemia (HP:0002154)4.96432961
10Prolonged partial thromboplastin time (HP:0003645)4.87282202
11Hyperammonemia (HP:0001987)4.82089507
12Abnormality of glycine metabolism (HP:0010895)4.81806925
13Abnormality of serine family amino acid metabolism (HP:0010894)4.81806925
14Hyperlipoproteinemia (HP:0010980)4.77379349
15Personality changes (HP:0000751)4.62593086
16* Abnormality of fatty-acid metabolism (HP:0004359)4.58637103
17Acanthocytosis (HP:0001927)4.54550216
18Cerebral hypomyelination (HP:0006808)4.47832479
19Hypoglycemic coma (HP:0001325)4.47038600
20Ketosis (HP:0001946)4.46028041
21Complement deficiency (HP:0004431)4.18015503
22Absent rod-and cone-mediated responses on ERG (HP:0007688)4.15395186
23Hypolipoproteinemia (HP:0010981)4.04974752
24Generalized aminoaciduria (HP:0002909)3.97307383
25Abnormality of glutamine family amino acid metabolism (HP:0010902)3.82604815
26Hypoalphalipoproteinemia (HP:0003233)3.78661709
27Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.78182042
28Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.78102478
29Abnormality of aspartate family amino acid metabolism (HP:0010899)3.76292801
30Abnormality of sulfur amino acid metabolism (HP:0004339)3.74651642
313-Methylglutaconic aciduria (HP:0003535)3.69829226
32Dicarboxylic aciduria (HP:0003215)3.68912763
33Abnormality of dicarboxylic acid metabolism (HP:0010995)3.68912763
34Ketoacidosis (HP:0001993)3.68462894
35Abnormality of methionine metabolism (HP:0010901)3.55139988
36Delusions (HP:0000746)3.54648733
37Fat malabsorption (HP:0002630)3.53870283
38Abnormality of the common coagulation pathway (HP:0010990)3.49675920
39Joint hemorrhage (HP:0005261)3.39640358
40Abnormality of serum amino acid levels (HP:0003112)3.39305610
41Abnormality of the intrinsic pathway (HP:0010989)3.36031470
42Epidermoid cyst (HP:0200040)3.32009674
43Lethargy (HP:0001254)3.24010327
44Self-mutilation (HP:0000742)3.21603316
45Disinhibition (HP:0000734)3.20784956
46Decreased central vision (HP:0007663)3.18761170
47Cerebral edema (HP:0002181)3.15062485
48Postnatal microcephaly (HP:0005484)3.14690641
49Gout (HP:0001997)3.13559412
50Abnormality of complement system (HP:0005339)3.05662284
51Metabolic acidosis (HP:0001942)3.03829829
52Dyskinesia (HP:0100660)3.03026525
53Pendular nystagmus (HP:0012043)3.01736490
54Delayed CNS myelination (HP:0002188)2.98250698
55Abnormality of pyrimidine metabolism (HP:0004353)2.91739788
56Abnormality of nucleobase metabolism (HP:0010932)2.90144396
57Abnormality of purine metabolism (HP:0004352)2.89346699
58Abnormal rod and cone electroretinograms (HP:0008323)2.88510266
59Conjugated hyperbilirubinemia (HP:0002908)2.87916208
60Proximal tubulopathy (HP:0000114)2.85562036
61Hyperbilirubinemia (HP:0002904)2.85102230
62Steatorrhea (HP:0002570)2.81876579
63Oligomenorrhea (HP:0000876)2.78612642
64Premature ovarian failure (HP:0008209)2.72589271
65Hypercholesterolemia (HP:0003124)2.71251756
66Generalized myoclonic seizures (HP:0002123)2.67074017
67Abnormality of alanine metabolism (HP:0010916)2.66165382
68Hyperalaninemia (HP:0003348)2.66165382
69Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.66165382
70Inappropriate behavior (HP:0000719)2.62596471
71Dialeptic seizures (HP:0011146)2.61547224
72Hepatic necrosis (HP:0002605)2.60638341
73Vomiting (HP:0002013)2.60628587
74Unsteady gait (HP:0002317)2.60411726
75Epileptic encephalopathy (HP:0200134)2.59801636
76Absence seizures (HP:0002121)2.58840040
77Glycosuria (HP:0003076)2.54512613
78Abnormality of urine glucose concentration (HP:0011016)2.54512613
79Bile duct proliferation (HP:0001408)2.53914153
80Abnormal biliary tract physiology (HP:0012439)2.53914153
81CNS hypomyelination (HP:0003429)2.50443011
82Visual hallucinations (HP:0002367)2.50109761
83Acute hepatic failure (HP:0006554)2.49107726
84Hepatocellular carcinoma (HP:0001402)2.48678321
85Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.48560619
86Focal seizures (HP:0007359)2.48442444
87Myoglobinuria (HP:0002913)2.45600908
88Hyperkalemia (HP:0002153)2.44562386
89Nausea (HP:0002018)2.41417914
90Renal cortical cysts (HP:0000803)2.38969073
91Acute encephalopathy (HP:0006846)2.37259630
92Vascular calcification (HP:0004934)2.35013085
93Irritability (HP:0000737)2.31685970
94Progressive inability to walk (HP:0002505)2.31677754
95Spastic diplegia (HP:0001264)2.31247378
96Malnutrition (HP:0004395)2.30812235
97Myopathic facies (HP:0002058)2.28953900
98Pancreatitis (HP:0001733)2.28411035
99Inability to walk (HP:0002540)2.27936597
100Hyperuricemia (HP:0002149)2.27680341
101Increased purine levels (HP:0004368)2.27680341
102Skin nodule (HP:0200036)2.27278780
103Abnormality of the labia minora (HP:0012880)2.27134780
104Increased hepatocellular lipid droplets (HP:0006565)2.27036038
105Impaired vibration sensation in the lower limbs (HP:0002166)2.25075412
106Drooling (HP:0002307)2.22606117
107Hypoglycemic seizures (HP:0002173)2.17137368
108Chronic bronchitis (HP:0004469)2.16208753
109Choreoathetosis (HP:0001266)2.16062540
110Increased serum pyruvate (HP:0003542)2.15430609
111Abnormality of glycolysis (HP:0004366)2.15430609
112Increased muscle lipid content (HP:0009058)2.14001191
113Alkalosis (HP:0001948)2.13357386
114Dry hair (HP:0011359)2.13235817
115Excessive salivation (HP:0003781)2.10990354
116Myocardial infarction (HP:0001658)2.10958656
117Abnormal cartilage morphology (HP:0002763)2.10623152
118Late onset (HP:0003584)2.10561115
119Abnormal gallbladder morphology (HP:0012437)2.09173110
120Methylmalonic aciduria (HP:0012120)2.08699262
121Cardiovascular calcification (HP:0011915)2.08653874
122Opisthotonus (HP:0002179)2.08309641
123Rhabdomyolysis (HP:0003201)2.08258550
124Neonatal onset (HP:0003623)2.07849712
125Attenuation of retinal blood vessels (HP:0007843)2.07545389
126Brushfield spots (HP:0001088)2.06960132
127Exercise-induced muscle cramps (HP:0003710)2.06608600
128Atonic seizures (HP:0010819)2.05283951
129Cholelithiasis (HP:0001081)2.04078215
130Septo-optic dysplasia (HP:0100842)2.04077666
131Intellectual disability, profound (HP:0002187)2.03729893
132Hyperventilation (HP:0002883)2.00795186
133Lipid accumulation in hepatocytes (HP:0006561)2.00038832
134Poikilocytosis (HP:0004447)1.97819593
135Psychosis (HP:0000709)1.97741887
136Abnormality of proline metabolism (HP:0010907)1.96976794
137Hydroxyprolinuria (HP:0003080)1.96976794
138Increased intramyocellular lipid droplets (HP:0012240)1.96286863
139Ankle clonus (HP:0011448)1.95832656
140Abnormality of the vocal cords (HP:0008777)1.95706276
141Systemic lupus erythematosus (HP:0002725)1.94615111
142Enlarged kidneys (HP:0000105)1.93144544
143Lissencephaly (HP:0001339)1.91695316
144Lactic acidosis (HP:0003128)1.90989455
145Abnormal enzyme/coenzyme activity (HP:0012379)1.90277949
146Hyperinsulinemic hypoglycemia (HP:0000825)1.89073107
147Prostate neoplasm (HP:0100787)1.88771272
148Hyperglycemia (HP:0003074)1.88708524
149Abnormality of vitamin metabolism (HP:0100508)1.88305344
150Genital tract atresia (HP:0001827)1.88076490
151Anencephaly (HP:0002323)1.87990691
152Sensorimotor neuropathy (HP:0007141)1.87056304
153Bilateral microphthalmos (HP:0007633)1.86719359
154Memory impairment (HP:0002354)1.86517180
155Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.86425478
156Generalized tonic-clonic seizures (HP:0002069)1.85612313
157Abnormal gallbladder physiology (HP:0012438)1.84783096
158Cholecystitis (HP:0001082)1.84783096
159Constricted visual fields (HP:0001133)1.83900248
160IgM deficiency (HP:0002850)1.82416458
161Febrile seizures (HP:0002373)1.82207688
162Spontaneous abortion (HP:0005268)1.81586042
163Acute necrotizing encephalopathy (HP:0006965)1.81168472
164Symptomatic seizures (HP:0011145)1.81069672
165Abnormal hair whorl (HP:0010721)1.79538023
166Rickets (HP:0002748)1.77266468
167Elevated hepatic transaminases (HP:0002910)1.76326914
168Hepatocellular necrosis (HP:0001404)1.76212666
169Irregular epiphyses (HP:0010582)1.75507556
170Colon cancer (HP:0003003)1.75479276
171Increased serum lactate (HP:0002151)1.75406431
172Death in childhood (HP:0003819)1.75201884
173Keratoconus (HP:0000563)1.74548064
174Increased corneal curvature (HP:0100692)1.74548064
175Scanning speech (HP:0002168)1.73562307
176Chronic otitis media (HP:0000389)1.73522029
177Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.72672486
178Emotional lability (HP:0000712)1.71628411
179Hemiparesis (HP:0001269)1.70011020
180Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.69931549
181True hermaphroditism (HP:0010459)1.68618951
182Muscle fiber inclusion bodies (HP:0100299)1.68468623
183Polyphagia (HP:0002591)1.67541459
184Azoospermia (HP:0000027)1.67366352
185Abnormality of lateral ventricle (HP:0030047)1.66914763
186Status epilepticus (HP:0002133)1.66900530
187Vaginal atresia (HP:0000148)1.66496672
188Abnormal spermatogenesis (HP:0008669)1.66054714
189Cellular immunodeficiency (HP:0005374)1.63970218

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.98633411
2TAOK16.24495280
3VRK24.40891206
4ZAK4.34385940
5SIK13.86131968
6SRPK13.66275737
7ERN13.51679741
8VRK13.21023561
9FGFR43.18894537
10CDC72.84827700
11TSSK62.57210567
12MST1R2.46666918
13PDK32.44507145
14PDK42.44507145
15PDK22.42201413
16MAPK132.11193067
17TIE12.10160705
18CDK192.02858555
19MAP2K41.98352870
20MKNK21.90590975
21INSRR1.87452159
22BMPR1B1.85292145
23NEK91.84844173
24MYLK1.81127964
25MKNK11.78063257
26PIK3CG1.77327799
27WNK41.76591215
28PKN21.66316538
29TTK1.59385537
30STK38L1.52250792
31MAP3K31.52121696
32FLT31.49454659
33RIPK41.47571168
34TLK11.44975293
35MAP2K31.44704581
36MAPK111.44416559
37OBSCN1.40955182
38PINK11.40342306
39TRIB31.37591929
40ABL21.34492646
41PIK3CA1.34055675
42NEK11.32551457
43ERBB41.30939672
44DYRK21.28019440
45IRAK31.25789617
46STK161.23000657
47TTN1.17924378
48STK391.17506189
49OXSR11.16987431
50FRK1.14415122
51MAP3K41.13523902
52TAOK31.13474080
53EPHB11.12428385
54TYK21.07779438
55PLK31.06619274
56AKT31.06102968
57KDR1.05862237
58CAMK11.05666090
59MAP4K11.05557529
60ALK1.05335559
61CDK31.03965820
62CAMKK10.98044509
63STK110.93386974
64UHMK10.91822125
65PRKAA20.89974708
66WNK30.89599683
67CAMK1D0.88589718
68JAK20.88014024
69MET0.85948295
70LATS10.83575631
71NME20.82481635
72GRK10.80643549
73MAP3K70.80327285
74MAP2K20.78636994
75PTK60.78595649
76DAPK20.77493055
77EIF2AK10.77256455
78PKN10.76359398
79MAP2K10.74955513
80TGFBR20.73866898
81CAMK40.73843107
82CAMK2G0.70983732
83MAP2K60.70336413
84EIF2AK30.69156629
85CCNB10.68977783
86CDK70.68333488
87PRKCG0.67681916
88PLK10.67613810
89TNIK0.66542593
90TNK20.65197248
91MAP2K70.64229409
92MAP3K110.63882605
93AURKB0.63747481
94PRKCQ0.61423603
95MAPK120.60616850
96CSNK1D0.60573137
97TGFBR10.59998249
98BRSK10.59608182
99FGFR20.59345273
100GRK60.59152624
101CDK60.58537064
102BMX0.58140841
103MAPK40.57922204
104EPHA30.57708822
105PHKG10.57084478
106PHKG20.57084478
107DYRK1A0.57022847
108CSNK1G20.56467331
109SGK4940.56270245
110SGK2230.56270245
111PDPK10.55982386
112ERBB20.55250507
113SGK20.54759703
114JAK10.54651541
115PRKCE0.54501952
116PRKAA10.53796404
117ATR0.53681101
118PRKACA0.53406014
119MAPK150.53282003
120TAOK20.53177325
121SGK30.52952225
122CAMKK20.52873762
123MAP3K20.51847649
124PBK0.51493291
125DAPK10.50900151
126AURKA0.50416138
127PRKACG0.47297180
128CSNK1G30.45597421
129TESK20.45339918
130BRSK20.44365197
131CAMK2A0.43126534
132PASK0.40042786
133PRKDC0.39904465
134PRKG10.39835678
135ATM0.39016126
136IRAK10.38812491
137YES10.38548951
138SGK10.38022812
139NEK60.37621473
140GRK70.37532572
141EPHA40.36390321
142PRKCZ0.35216003
143MAPK70.35097207
144LMTK20.34788835
145CDK40.33347496
146GSK3A0.32362286
147CDK10.32330508
148MARK10.32267043
149IRAK20.32219053
150MINK10.31405906
151CDK50.29834387
152MAPK90.28750077
153CDK20.28243852
154NUAK10.27438568
155DAPK30.27227088
156GSK3B0.25853102
157PIM10.25150938
158NTRK20.24898636
159MAPK30.24824405
160PRKACB0.24442357
161PAK30.24271127
162NTRK30.23870163
163RET0.23451172
164BUB10.23199995
165RPS6KB20.22225388
166IGF1R0.21926194
167CAMK1G0.21297904
168TBK10.21003283
169CAMK2D0.18106661
170PRKCA0.17682057
171CSNK1G10.17675948

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.60477295
2* Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.97059014
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.96711442
4Mismatch repair_Homo sapiens_hsa034302.95907738
5Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.92190386
6Fatty acid degradation_Homo sapiens_hsa000712.87835935
7Nitrogen metabolism_Homo sapiens_hsa009102.74796197
8DNA replication_Homo sapiens_hsa030302.74487780
9Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.71855017
10Propanoate metabolism_Homo sapiens_hsa006402.64100054
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.49340376
12Arginine biosynthesis_Homo sapiens_hsa002202.46913477
13Tryptophan metabolism_Homo sapiens_hsa003802.46622037
14Butanoate metabolism_Homo sapiens_hsa006502.44899195
15Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.44661054
16Base excision repair_Homo sapiens_hsa034102.43284080
172-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.30504113
18Pentose and glucuronate interconversions_Homo sapiens_hsa000402.25130981
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.16532625
20Fatty acid metabolism_Homo sapiens_hsa012122.13593653
21Peroxisome_Homo sapiens_hsa041462.11925381
22Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.08137916
23Complement and coagulation cascades_Homo sapiens_hsa046102.03857614
24beta-Alanine metabolism_Homo sapiens_hsa004101.87174102
25Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.86393574
26PPAR signaling pathway_Homo sapiens_hsa033201.86177050
27Chemical carcinogenesis_Homo sapiens_hsa052041.84267681
28Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.78796645
29Histidine metabolism_Homo sapiens_hsa003401.78183901
30Sulfur metabolism_Homo sapiens_hsa009201.73328753
31Caffeine metabolism_Homo sapiens_hsa002321.70602511
32Drug metabolism - other enzymes_Homo sapiens_hsa009831.69813564
33Fatty acid elongation_Homo sapiens_hsa000621.68045885
34Pyruvate metabolism_Homo sapiens_hsa006201.67562130
35Carbon metabolism_Homo sapiens_hsa012001.64260929
36Steroid hormone biosynthesis_Homo sapiens_hsa001401.63027743
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.62242996
38Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.60508871
39Homologous recombination_Homo sapiens_hsa034401.56098890
40Phenylalanine metabolism_Homo sapiens_hsa003601.53442017
41Nicotine addiction_Homo sapiens_hsa050331.48613161
42Retinol metabolism_Homo sapiens_hsa008301.48363705
43Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.46870288
44Biosynthesis of amino acids_Homo sapiens_hsa012301.42642710
45Selenocompound metabolism_Homo sapiens_hsa004501.41019747
46Tyrosine metabolism_Homo sapiens_hsa003501.40197999
47Folate biosynthesis_Homo sapiens_hsa007901.36426366
48Cysteine and methionine metabolism_Homo sapiens_hsa002701.32677891
49Nucleotide excision repair_Homo sapiens_hsa034201.32338509
50Starch and sucrose metabolism_Homo sapiens_hsa005001.30541027
51RNA polymerase_Homo sapiens_hsa030201.28576243
52Bile secretion_Homo sapiens_hsa049761.25040532
53Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.15760482
54mRNA surveillance pathway_Homo sapiens_hsa030151.15399777
55Vitamin B6 metabolism_Homo sapiens_hsa007501.14145294
56Non-homologous end-joining_Homo sapiens_hsa034501.12565327
57Fat digestion and absorption_Homo sapiens_hsa049751.12465597
58Steroid biosynthesis_Homo sapiens_hsa001001.12173560
59Sulfur relay system_Homo sapiens_hsa041221.09969965
60Staphylococcus aureus infection_Homo sapiens_hsa051501.09237742
61Arginine and proline metabolism_Homo sapiens_hsa003301.08611594
62Purine metabolism_Homo sapiens_hsa002301.02558590
63Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.01340707
64Cyanoamino acid metabolism_Homo sapiens_hsa004600.94914591
65Spliceosome_Homo sapiens_hsa030400.94727564
66Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.93434973
67Glutathione metabolism_Homo sapiens_hsa004800.92202846
68Taste transduction_Homo sapiens_hsa047420.90620749
69ABC transporters_Homo sapiens_hsa020100.87610012
70RNA degradation_Homo sapiens_hsa030180.87169947
71Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.86770947
72Glycerolipid metabolism_Homo sapiens_hsa005610.86086851
73Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.85787090
74Olfactory transduction_Homo sapiens_hsa047400.85581320
75Insulin secretion_Homo sapiens_hsa049110.83449655
76Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.82898657
77Pentose phosphate pathway_Homo sapiens_hsa000300.78114306
78Maturity onset diabetes of the young_Homo sapiens_hsa049500.76582856
79Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.75639689
80Phototransduction_Homo sapiens_hsa047440.75154752
81Vitamin digestion and absorption_Homo sapiens_hsa049770.74848087
82Fructose and mannose metabolism_Homo sapiens_hsa000510.73317703
83Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.72914785
84One carbon pool by folate_Homo sapiens_hsa006700.72548321
85Long-term depression_Homo sapiens_hsa047300.72171339
86RNA transport_Homo sapiens_hsa030130.71283725
87Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.69445224
88Circadian entrainment_Homo sapiens_hsa047130.68044688
89Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.68026892
90Glutamatergic synapse_Homo sapiens_hsa047240.64062862
91* Metabolic pathways_Homo sapiens_hsa011000.63497480
92Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.60490118
93GABAergic synapse_Homo sapiens_hsa047270.60432805
94Fanconi anemia pathway_Homo sapiens_hsa034600.59781100
95Lysine degradation_Homo sapiens_hsa003100.59487475
96Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.56835570
97Vascular smooth muscle contraction_Homo sapiens_hsa042700.53799571
98Fatty acid biosynthesis_Homo sapiens_hsa000610.50288193
99Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.49995951
100Cell cycle_Homo sapiens_hsa041100.49512597
101Serotonergic synapse_Homo sapiens_hsa047260.48560989
102Oxidative phosphorylation_Homo sapiens_hsa001900.47465708
103Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.46599362
104Morphine addiction_Homo sapiens_hsa050320.45214331
105Galactose metabolism_Homo sapiens_hsa000520.42952509
106Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.42811169
107Amphetamine addiction_Homo sapiens_hsa050310.42224453
108Dopaminergic synapse_Homo sapiens_hsa047280.40521646
109Calcium signaling pathway_Homo sapiens_hsa040200.40081871
110Ether lipid metabolism_Homo sapiens_hsa005650.36624595
111Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.35594386
112Parkinsons disease_Homo sapiens_hsa050120.35221964
113Adipocytokine signaling pathway_Homo sapiens_hsa049200.32915099
114Salivary secretion_Homo sapiens_hsa049700.30308581
115Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.24954735
116Insulin resistance_Homo sapiens_hsa049310.22490075
117Glycerophospholipid metabolism_Homo sapiens_hsa005640.20104775
118alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.19394695
119Alzheimers disease_Homo sapiens_hsa050100.19390655
120Prion diseases_Homo sapiens_hsa050200.16888011
121Linoleic acid metabolism_Homo sapiens_hsa005910.14443279
122AMPK signaling pathway_Homo sapiens_hsa041520.10601480
123Regulation of autophagy_Homo sapiens_hsa041400.10121998
124Glucagon signaling pathway_Homo sapiens_hsa049220.08955667
125Protein export_Homo sapiens_hsa030600.04122310
126Huntingtons disease_Homo sapiens_hsa050160.03684013
127Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.03626883
128Arachidonic acid metabolism_Homo sapiens_hsa005900.01182491
129Ovarian steroidogenesis_Homo sapiens_hsa04913-0.1340237
130Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1262354
131Lysosome_Homo sapiens_hsa04142-0.1215229
132Pyrimidine metabolism_Homo sapiens_hsa00240-0.0935408
133Proteasome_Homo sapiens_hsa03050-0.0847050
134Other glycan degradation_Homo sapiens_hsa00511-0.0796565
135Protein digestion and absorption_Homo sapiens_hsa04974-0.0770648
136Cardiac muscle contraction_Homo sapiens_hsa04260-0.0766021
137Renin-angiotensin system_Homo sapiens_hsa04614-0.0616779
138Insulin signaling pathway_Homo sapiens_hsa04910-0.0471216
139Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970-0.0371856

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