ACAD9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the acyl-CoA dehydrogenase family. Members of this family of proteins localize to the mitochondria and catalyze the rate-limiting step in the beta-oxidation of fatty acyl-CoA. The encoded protein is specifically active toward palmitoyl-CoA and long-chain unsaturated substrates. Mutations in this gene cause acyl-CoA dehydrogenase family member type 9 deficiency. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)6.02999573
2Golgi transport vesicle coating (GO:0048200)6.02999573
3deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.60913983
4cilium or flagellum-dependent cell motility (GO:0001539)4.59186299
5pentose-phosphate shunt (GO:0006098)4.49193475
6protein maturation by protein folding (GO:0022417)4.45210214
7DNA unwinding involved in DNA replication (GO:0006268)4.39054885
8mitotic chromosome condensation (GO:0007076)4.25738911
9G-protein coupled receptor internalization (GO:0002031)4.17194237
10negative regulation of granulocyte differentiation (GO:0030853)4.08458972
11left/right axis specification (GO:0070986)4.02938662
12retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.99688870
13NADH metabolic process (GO:0006734)3.96686771
14glucose catabolic process (GO:0006007)3.95190273
15peptidyl-arginine omega-N-methylation (GO:0035247)3.92605652
16glucocorticoid biosynthetic process (GO:0006704)3.91842865
17NADPH regeneration (GO:0006740)3.86648529
18spliceosomal tri-snRNP complex assembly (GO:0000244)3.82172407
19folic acid metabolic process (GO:0046655)3.77363431
20DNA strand elongation involved in DNA replication (GO:0006271)3.74631877
21embryonic retina morphogenesis in camera-type eye (GO:0060059)3.72683221
22maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.71109584
23negative regulation of cell size (GO:0045792)3.71080350
24negative regulation of release of cytochrome c from mitochondria (GO:0090201)3.69577014
25mitotic nuclear envelope reassembly (GO:0007084)3.69030149
26nuclear envelope reassembly (GO:0031468)3.69030149
27cilium movement (GO:0003341)3.68746343
28DNA strand elongation (GO:0022616)3.66155930
29tricarboxylic acid metabolic process (GO:0072350)3.65119374
30histone H3-K4 trimethylation (GO:0080182)3.64584064
31protein retention in ER lumen (GO:0006621)3.60600965
32axonemal dynein complex assembly (GO:0070286)3.52662012
33UV protection (GO:0009650)3.48342346
34negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.43554136
35negative regulation of translation, ncRNA-mediated (GO:0040033)3.43554136
36regulation of translation, ncRNA-mediated (GO:0045974)3.43554136
37pentose metabolic process (GO:0019321)3.39816251
38import into cell (GO:0098657)3.37762261
39dosage compensation (GO:0007549)3.36679267
40telomere maintenance via semi-conservative replication (GO:0032201)3.33767979
41epithelial cell differentiation involved in prostate gland development (GO:0060742)3.33372122
42tRNA methylation (GO:0030488)3.32386676
43righting reflex (GO:0060013)3.32331733
44nucleobase-containing small molecule interconversion (GO:0015949)3.30214027
45ribosomal small subunit biogenesis (GO:0042274)3.28821806
46proline biosynthetic process (GO:0006561)3.27923068
47protoporphyrinogen IX biosynthetic process (GO:0006782)3.25903527
48negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.24733161
49cell morphogenesis involved in neuron differentiation (GO:0048667)3.21761231
50protoporphyrinogen IX metabolic process (GO:0046501)3.21049422
51regulation of non-canonical Wnt signaling pathway (GO:2000050)3.18072622
52desmosome organization (GO:0002934)3.17157730
53androgen biosynthetic process (GO:0006702)3.13847077
54motile cilium assembly (GO:0044458)3.08340133
55GDP-mannose metabolic process (GO:0019673)3.08118004
56negative regulation of keratinocyte proliferation (GO:0010839)3.06012814
57regulation of translational fidelity (GO:0006450)3.05882079
58DNA replication initiation (GO:0006270)3.05257190
59regulation of mitochondrial translation (GO:0070129)3.04291609
60startle response (GO:0001964)3.02829361
61keratinocyte proliferation (GO:0043616)3.01435805
62ventricular system development (GO:0021591)3.00261114
63mitotic sister chromatid segregation (GO:0000070)2.98954123
64positive regulation of NIK/NF-kappaB signaling (GO:1901224)2.98731579
65viral mRNA export from host cell nucleus (GO:0046784)2.96164907
66barbed-end actin filament capping (GO:0051016)2.96161636
67postsynaptic membrane organization (GO:0001941)2.95543738
68regulation of mammary gland epithelial cell proliferation (GO:0033599)2.94688210
69oxaloacetate metabolic process (GO:0006107)2.93680593
70peptidyl-arginine methylation (GO:0018216)2.92537399
71peptidyl-arginine N-methylation (GO:0035246)2.92537399
72pinocytosis (GO:0006907)2.90267931
73cellular protein complex localization (GO:0034629)2.89718152
74phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.89477884
75negative regulation of lipase activity (GO:0060192)2.88436681
76sphingosine metabolic process (GO:0006670)2.88319532
77regulation of sequestering of triglyceride (GO:0010889)2.87915961
78telomere maintenance via recombination (GO:0000722)2.87714053
79DNA strand renaturation (GO:0000733)2.86276254
80interkinetic nuclear migration (GO:0022027)2.85881575
81germinal center formation (GO:0002467)2.85820609
82chaperone mediated protein folding requiring cofactor (GO:0051085)2.84133724
83diol metabolic process (GO:0034311)2.83941111
84epithelial cilium movement (GO:0003351)2.83513649
85sphingoid metabolic process (GO:0046519)2.83371971
86urea cycle (GO:0000050)2.82055006
87histone arginine methylation (GO:0034969)2.81584645
88regulation of pigment cell differentiation (GO:0050932)2.80520305
89tricarboxylic acid cycle (GO:0006099)2.77002812
90cell proliferation in forebrain (GO:0021846)2.76546573
91positive regulation of smoothened signaling pathway (GO:0045880)2.76430531
92negative regulation of DNA-dependent DNA replication (GO:2000104)2.75054256
93regulation of NIK/NF-kappaB signaling (GO:1901222)2.74196100
94regulation of phospholipase A2 activity (GO:0032429)2.72732480
95negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.72414515
96histone H3-K36 demethylation (GO:0070544)2.72122812
97rRNA transcription (GO:0009303)2.71655721
98regulation of water loss via skin (GO:0033561)2.71638321
99female gonad development (GO:0008585)2.69763812
100mitochondrial fusion (GO:0008053)2.69627771
101hemidesmosome assembly (GO:0031581)2.69413347
102phosphatidylethanolamine metabolic process (GO:0046337)2.68734373
103urea metabolic process (GO:0019627)2.67857852
104inner ear receptor stereocilium organization (GO:0060122)2.66613365
105embryonic viscerocranium morphogenesis (GO:0048703)2.66194806
106monosaccharide biosynthetic process (GO:0046364)2.66085337
107positive regulation of nuclease activity (GO:0032075)2.65857749
108establishment of viral latency (GO:0019043)2.64860389
109polyol transport (GO:0015791)2.64263984
110activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.63252528
111peptidyl-lysine dimethylation (GO:0018027)2.62744677
112neuron projection extension involved in neuron projection guidance (GO:1902284)2.62468463
113axon extension involved in axon guidance (GO:0048846)2.62468463
114regulation of germinal center formation (GO:0002634)2.62244416
1152-oxoglutarate metabolic process (GO:0006103)2.61991908
116regulation of bile acid biosynthetic process (GO:0070857)2.61366871
117cellular hyperosmotic response (GO:0071474)2.61342148
118mitotic recombination (GO:0006312)2.60738410
119sympathetic nervous system development (GO:0048485)2.60106027
120keratinocyte development (GO:0003334)2.59252549
121mesenchymal cell differentiation (GO:0048762)2.58805058
122reflex (GO:0060004)2.57983717
123nitrogen cycle metabolic process (GO:0071941)2.57055901
124regulation of glucose import in response to insulin stimulus (GO:2001273)2.55877771
125regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.54784265
126sister chromatid segregation (GO:0000819)2.52727177
127maternal placenta development (GO:0001893)2.52276293
128protein complex localization (GO:0031503)2.51974318
129mitochondrion distribution (GO:0048311)2.51890374
130mannose metabolic process (GO:0006013)2.51289337
131replicative senescence (GO:0090399)2.51091950
132heme biosynthetic process (GO:0006783)2.50873817
133myoblast fusion (GO:0007520)2.50457950
134epithelial cell differentiation involved in kidney development (GO:0035850)2.49517465
135establishment of integrated proviral latency (GO:0075713)2.48397424
136pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.47501515
137homocysteine metabolic process (GO:0050667)2.47462439
138positive regulation of cellular amide metabolic process (GO:0034250)2.47281626
139cornea development in camera-type eye (GO:0061303)2.47110935
140detection of bacterium (GO:0016045)2.47039126
141DNA integration (GO:0015074)2.46918445
142positive regulation of cardiac muscle cell differentiation (GO:2000727)2.46803710
143endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.46500134
144regulation of Cdc42 GTPase activity (GO:0043088)2.46317585
145rRNA catabolic process (GO:0016075)2.46312955
146regulation of protein polyubiquitination (GO:1902914)2.46021550
147positive regulation of interleukin-1 beta secretion (GO:0050718)2.44876947
148establishment of skin barrier (GO:0061436)2.44609946
149nonmotile primary cilium assembly (GO:0035058)2.44185159
150detection of other organism (GO:0098543)2.43902317
151mesenchymal-epithelial cell signaling (GO:0060638)2.43874387
152biotin metabolic process (GO:0006768)2.43440187
153limb bud formation (GO:0060174)2.42340560
154regulation of translational termination (GO:0006449)2.42289012
155positive regulation of lamellipodium assembly (GO:0010592)2.42064973
156positive regulation of protein kinase C signaling (GO:0090037)2.41797270
157regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.41133707
158mitochondrial genome maintenance (GO:0000002)2.40855095
159positive regulation of receptor biosynthetic process (GO:0010870)2.40581966
160inflammatory response to antigenic stimulus (GO:0002437)2.40084932
161developmental induction (GO:0031128)2.39995197
162carnitine shuttle (GO:0006853)2.39546209
163gluconeogenesis (GO:0006094)2.39424024
164chromosome condensation (GO:0030261)2.39268898
165base-excision repair (GO:0006284)2.38557142
166early endosome to late endosome transport (GO:0045022)2.38105014
167apoptotic process involved in morphogenesis (GO:0060561)2.38033393
168DNA duplex unwinding (GO:0032508)2.37659236
169mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.37563109
170endoplasmic reticulum unfolded protein response (GO:0030968)2.36991791
171microtubule depolymerization (GO:0007019)2.36617972
172positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.35338890
173phospholipid homeostasis (GO:0055091)2.35160863
174protein heterotetramerization (GO:0051290)2.34522290
175mitotic nuclear envelope disassembly (GO:0007077)2.34325326
176low-density lipoprotein particle clearance (GO:0034383)2.33524233
177nuclear envelope organization (GO:0006998)2.32597416
1783-UTR-mediated mRNA stabilization (GO:0070935)2.32220440
179cell-cell signaling involved in cell fate commitment (GO:0045168)2.31840253
180positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.31322683
181regulation of nuclease activity (GO:0032069)2.31002015
182glucocorticoid metabolic process (GO:0008211)2.30794029
183peptidyl-lysine trimethylation (GO:0018023)2.30516288
184cilium assembly (GO:0042384)2.30403486
185hexose biosynthetic process (GO:0019319)2.30220715
186cellular response to calcium ion (GO:0071277)2.29202699
187negative regulation of B cell apoptotic process (GO:0002903)2.29006561
188linoleic acid metabolic process (GO:0043651)2.27795124
189negative regulation of osteoblast proliferation (GO:0033689)2.27594608
190proline metabolic process (GO:0006560)2.27587244
191organ induction (GO:0001759)2.26363520
192smoothened signaling pathway (GO:0007224)2.25915151
193cilium organization (GO:0044782)2.25597528
194indole-containing compound catabolic process (GO:0042436)2.25003118
195indolalkylamine catabolic process (GO:0046218)2.25003118
196tryptophan catabolic process (GO:0006569)2.25003118
197cerebellar Purkinje cell differentiation (GO:0021702)2.24988424
198amine catabolic process (GO:0009310)2.23888729

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.08488881
2GBX2_23144817_ChIP-Seq_PC3_Human3.73817836
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.16313063
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.94724721
5TP63_17297297_ChIP-ChIP_HaCaT_Human2.74456467
6PCGF2_27294783_Chip-Seq_ESCs_Mouse2.73382848
7BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.68851349
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.62465449
9TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.58133990
10MYC_18555785_ChIP-Seq_MESCs_Mouse2.51907795
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.50959865
12SUZ12_27294783_Chip-Seq_NPCs_Mouse2.49146489
13PCGF2_27294783_Chip-Seq_NPCs_Mouse2.49039481
14GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.45723531
15FLI1_27457419_Chip-Seq_LIVER_Mouse2.43816156
16NFE2_27457419_Chip-Seq_LIVER_Mouse2.39169214
17MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.36032916
18ZNF263_19887448_ChIP-Seq_K562_Human2.26994694
19VDR_21846776_ChIP-Seq_THP-1_Human2.26613749
20AR_21572438_ChIP-Seq_LNCaP_Human2.26073928
21* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.21168705
22TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.16691584
23EZH2_27294783_Chip-Seq_NPCs_Mouse2.11591580
24ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.08200532
25EZH2_22144423_ChIP-Seq_EOC_Human2.07766127
26MYC_22102868_ChIP-Seq_BL_Human2.06053654
27DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.02884959
28SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.02349983
29* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.01089438
30FOXM1_23109430_ChIP-Seq_U2OS_Human1.96804334
31TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.95178279
32CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.94965384
33NANOG_18555785_Chip-Seq_ESCs_Mouse1.93843985
34EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.90057042
35LXR_22292898_ChIP-Seq_THP-1_Human1.89688308
36PIAS1_25552417_ChIP-Seq_VCAP_Human1.84971621
37CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.84607013
38P53_22387025_ChIP-Seq_ESCs_Mouse1.83000076
39RARG_19884340_ChIP-ChIP_MEFs_Mouse1.80839668
40NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.80532217
41GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.78599590
42* E2F1_18555785_Chip-Seq_ESCs_Mouse1.78181834
43NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.77179091
44POU3F2_20337985_ChIP-ChIP_501MEL_Human1.75804805
45IGF1R_20145208_ChIP-Seq_DFB_Human1.74885997
46SRY_22984422_ChIP-ChIP_TESTIS_Rat1.73438446
47ELK3_25401928_ChIP-Seq_HUVEC_Human1.72597725
48SUZ12_18555785_Chip-Seq_ESCs_Mouse1.72306301
49XRN2_22483619_ChIP-Seq_HELA_Human1.70420098
50DROSHA_22980978_ChIP-Seq_HELA_Human1.70079556
51EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.68922123
52CMYC_18555785_Chip-Seq_ESCs_Mouse1.68439279
53PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.65752840
54STAT3_18555785_Chip-Seq_ESCs_Mouse1.65587530
55MYC_19030024_ChIP-ChIP_MESCs_Mouse1.64080738
56CDX2_19796622_ChIP-Seq_MESCs_Mouse1.63949734
57CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.62889955
58P300_18555785_Chip-Seq_ESCs_Mouse1.62549463
59AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.61293436
60OCT4_18555785_Chip-Seq_ESCs_Mouse1.60599326
61BMI1_23680149_ChIP-Seq_NPCS_Mouse1.60462277
62MYC_19079543_ChIP-ChIP_MESCs_Mouse1.59584171
63RUNX1_27457419_Chip-Seq_LIVER_Mouse1.59417551
64P300_19829295_ChIP-Seq_ESCs_Human1.58877222
65ZFX_18555785_ChIP-Seq_MESCs_Mouse1.58011234
66SMAD4_21799915_ChIP-Seq_A2780_Human1.57850525
67FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.57634289
68RACK7_27058665_Chip-Seq_MCF-7_Human1.56964059
69CBX2_27304074_Chip-Seq_ESCs_Mouse1.56908566
70PU1_27457419_Chip-Seq_LIVER_Mouse1.56350254
71TET1_21451524_ChIP-Seq_MESCs_Mouse1.56285795
72NELFA_20434984_ChIP-Seq_ESCs_Mouse1.56042184
73GABP_19822575_ChIP-Seq_HepG2_Human1.55950905
74HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.54354690
75THAP11_20581084_ChIP-Seq_MESCs_Mouse1.54168726
76JARID2_20064375_ChIP-Seq_MESCs_Mouse1.54046212
77CTBP1_25329375_ChIP-Seq_LNCAP_Human1.53574061
78* NMYC_18555785_Chip-Seq_ESCs_Mouse1.53171656
79TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.52985618
80KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.51297337
81OCT4_21477851_ChIP-Seq_ESCs_Mouse1.50815740
82FUS_26573619_Chip-Seq_HEK293_Human1.49323983
83SOX2_18555785_Chip-Seq_ESCs_Mouse1.48419383
84TAF15_26573619_Chip-Seq_HEK293_Human1.46161581
85ESRRB_18555785_Chip-Seq_ESCs_Mouse1.45381540
86POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.45174851
87TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.45174851
88STAT3_23295773_ChIP-Seq_U87_Human1.44764670
89* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.44647668
90EED_16625203_ChIP-ChIP_MESCs_Mouse1.43557875
91DCP1A_22483619_ChIP-Seq_HELA_Human1.43516404
92* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.42207009
93CRX_20693478_ChIP-Seq_RETINA_Mouse1.41852777
94* ZFX_18555785_Chip-Seq_ESCs_Mouse1.40490900
95* ETS1_20019798_ChIP-Seq_JURKAT_Human1.40224369
96P68_20966046_ChIP-Seq_HELA_Human1.39412322
97SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.39229441
98KDM5A_27292631_Chip-Seq_BREAST_Human1.38716623
99CTCF_18555785_Chip-Seq_ESCs_Mouse1.38481728
100SMAD3_21741376_ChIP-Seq_EPCs_Human1.38288672
101ARNT_22903824_ChIP-Seq_MCF-7_Human1.37959818
102SMAD1_18555785_Chip-Seq_ESCs_Mouse1.37924304
103ESR1_15608294_ChIP-ChIP_MCF-7_Human1.37714140
104SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.37638489
105KLF4_18555785_Chip-Seq_ESCs_Mouse1.37544460
106ELF1_20517297_ChIP-Seq_JURKAT_Human1.37464033
107AHR_22903824_ChIP-Seq_MCF-7_Human1.37382102
108CREB1_15753290_ChIP-ChIP_HEK293T_Human1.36309254
109SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.35970537
110ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.35482522
111CTBP2_25329375_ChIP-Seq_LNCAP_Human1.35292949
112SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.34971185
113KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.34950518
114SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.34620209
115THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.34590764
116TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.33487216
117TCF4_23295773_ChIP-Seq_U87_Human1.32656974
118TP53_18474530_ChIP-ChIP_U2OS_Human1.32437145
119* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.32050530
120KLF4_18555785_ChIP-Seq_MESCs_Mouse1.31597878
121EGR1_23403033_ChIP-Seq_LIVER_Mouse1.28842372
122AR_21909140_ChIP-Seq_LNCAP_Human1.28511453
123CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.28217727
124ZNF217_24962896_ChIP-Seq_MCF-7_Human1.28007810
125ELF1_17652178_ChIP-ChIP_JURKAT_Human1.26968032
126STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.26690529
127MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.26343559
128NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.26142343
129MYCN_18555785_ChIP-Seq_MESCs_Mouse1.26012775
130EZH2_27304074_Chip-Seq_ESCs_Mouse1.25960106
131SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.24835706
132SMAD_19615063_ChIP-ChIP_OVARY_Human1.24689942
133HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.24290251
134STAT6_21828071_ChIP-Seq_BEAS2B_Human1.24210804
135STAT3_1855785_ChIP-Seq_MESCs_Mouse1.23225993
136ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.22567365
137TP53_16413492_ChIP-PET_HCT116_Human1.22047338
138UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.21614553
139ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.21150818
140KDM2B_26808549_Chip-Seq_REH_Human1.20678914
141CLOCK_20551151_ChIP-Seq_293T_Human1.20603589
142EZH2_18974828_ChIP-Seq_MESCs_Mouse1.20379581
143RNF2_18974828_ChIP-Seq_MESCs_Mouse1.20379581
144CIITA_25753668_ChIP-Seq_RAJI_Human1.20103302
145TAL1_26923725_Chip-Seq_HPCs_Mouse1.19665525
146RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.19013456
147CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.18208704
148* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.17687752
149SALL1_21062744_ChIP-ChIP_HESCs_Human1.17578228
150CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.17360270
151PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.16834720
152TBL1_22424771_ChIP-Seq_293T_Human1.16327141
153CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.16218568
154YY1_21170310_ChIP-Seq_MESCs_Mouse1.15879750
155EGR1_19374776_ChIP-ChIP_THP-1_Human1.15863900
156BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.15692833
157NANOG_18555785_ChIP-Seq_MESCs_Mouse1.15540967
158ERG_20887958_ChIP-Seq_HPC-7_Mouse1.15321091
159KDM2B_26808549_Chip-Seq_SUP-B15_Human1.15045067
160SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.14998975
161SMC4_20622854_ChIP-Seq_HELA_Human1.14856518
162BCAT_22108803_ChIP-Seq_LS180_Human1.14316064
163KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.13942793
164TCF7_22412390_ChIP-Seq_EML_Mouse1.13438463
165CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.12199615
166ATF3_27146783_Chip-Seq_COLON_Human1.12032016
167RUNX2_22187159_ChIP-Seq_PCA_Human1.11579795
168TOP2B_26459242_ChIP-Seq_MCF-7_Human1.11300623
169FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.10887608
170SA1_27219007_Chip-Seq_ERYTHROID_Human1.10736614
171FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.10697475
172EZH2_27294783_Chip-Seq_ESCs_Mouse1.10526953
173CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10480155
174PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.10319237
175ER_23166858_ChIP-Seq_MCF-7_Human1.10152539
176Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.09981461
177EWS_26573619_Chip-Seq_HEK293_Human1.09316407
178JARID2_20075857_ChIP-Seq_MESCs_Mouse1.08706968
179KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.08236375
180ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.07683817
181RNF2_27304074_Chip-Seq_ESCs_Mouse1.07197811
182KDM2B_26808549_Chip-Seq_DND41_Human1.07013818
183UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.06874958
184E2F1_21310950_ChIP-Seq_MCF-7_Human1.06491544
185AR_25329375_ChIP-Seq_VCAP_Human1.06237401
186* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.06216800
187* TFEB_21752829_ChIP-Seq_HELA_Human1.06131836
188KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.04697250
189SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.04540263
190SRF_21415370_ChIP-Seq_HL-1_Mouse1.03281590
191PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03091167
192TBX5_21415370_ChIP-Seq_HL-1_Mouse1.02667692
193CTCF_27219007_Chip-Seq_ERYTHROID_Human1.02288848
194TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.02285950
195TP53_22127205_ChIP-Seq_IMR90_Human1.02064015
196SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.01807714
197CTCF_18555785_ChIP-Seq_MESCs_Mouse1.01786061
198HIF1A_21447827_ChIP-Seq_MCF-7_Human1.01280247
199BP1_19119308_ChIP-ChIP_Hs578T_Human1.01269451
200POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.01151856

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation6.08872254
2MP0001188_hyperpigmentation4.65474014
3MP0004381_abnormal_hair_follicle4.14379433
4MP0000383_abnormal_hair_follicle3.81039873
5MP0005058_abnormal_lysosome_morphology3.13139852
6MP0003136_yellow_coat_color3.11898135
7MP0004233_abnormal_muscle_weight3.04486000
8MP0002102_abnormal_ear_morphology2.87387748
9MP0000579_abnormal_nail_morphology2.65272059
10MP0002138_abnormal_hepatobiliary_system2.62222584
11MP0003693_abnormal_embryo_hatching2.60943626
12MP0000566_synostosis2.53307651
13MP0002877_abnormal_melanocyte_morpholog2.53261094
14MP0000427_abnormal_hair_cycle2.51441692
15MP0003111_abnormal_nucleus_morphology2.48996466
16MP0010678_abnormal_skin_adnexa2.48401921
17MP0010234_abnormal_vibrissa_follicle2.47402529
18MP0005670_abnormal_white_adipose2.39534084
19MP0005647_abnormal_sex_gland2.32211236
20MP0002254_reproductive_system_inflammat2.31990936
21MP0005174_abnormal_tail_pigmentation2.31767110
22MP0005409_darkened_coat_color2.31673629
23MP0010094_abnormal_chromosome_stability2.31513326
24MP0003191_abnormal_cellular_cholesterol2.22443244
25MP0009278_abnormal_bone_marrow2.22335848
26MP0002060_abnormal_skin_morphology2.21577300
27MP0000751_myopathy2.07973063
28MP0004742_abnormal_vestibular_system1.98178594
29MP0003566_abnormal_cell_adhesion1.97000531
30MP0000015_abnormal_ear_pigmentation1.96702516
31MP0004185_abnormal_adipocyte_glucose1.96323295
32MP0003806_abnormal_nucleotide_metabolis1.96161160
33MP0000003_abnormal_adipose_tissue1.93818151
34MP0005076_abnormal_cell_differentiation1.90271653
35MP0003077_abnormal_cell_cycle1.84766037
36MP0002269_muscular_atrophy1.83727953
37MP0009697_abnormal_copulation1.80058163
38MP0008007_abnormal_cellular_replicative1.79340840
39MP0003453_abnormal_keratinocyte_physiol1.78268194
40MP0003252_abnormal_bile_duct1.74867361
41MP0002928_abnormal_bile_duct1.72280953
42MP0005451_abnormal_body_composition1.70426746
43MP0001346_abnormal_lacrimal_gland1.69892559
44MP0005360_urolithiasis1.69100002
45MP0008057_abnormal_DNA_replication1.68530640
46MP0000747_muscle_weakness1.66747479
47MP0005083_abnormal_biliary_tract1.64995015
48MP0009840_abnormal_foam_cell1.58835753
49MP0000647_abnormal_sebaceous_gland1.57382641
50MP0003786_premature_aging1.57062306
51MP0004019_abnormal_vitamin_homeostasis1.55739663
52MP0001849_ear_inflammation1.53395641
53MP0009046_muscle_twitch1.52648873
54MP0008004_abnormal_stomach_pH1.51493381
55MP0005397_hematopoietic_system_phenotyp1.45248839
56MP0001545_abnormal_hematopoietic_system1.45248839
57MP0005375_adipose_tissue_phenotype1.45143145
58MP0005365_abnormal_bile_salt1.44324893
59MP0001486_abnormal_startle_reflex1.43663255
60MP0002249_abnormal_larynx_morphology1.41029993
61MP0008058_abnormal_DNA_repair1.38187355
62MP0004957_abnormal_blastocyst_morpholog1.37911849
63MP0005075_abnormal_melanosome_morpholog1.37471686
64MP0003045_fibrosis1.35937174
65MP0000759_abnormal_skeletal_muscle1.35072157
66MP0004858_abnormal_nervous_system1.32098257
67MP0010771_integument_phenotype1.29516637
68MP0006036_abnormal_mitochondrial_physio1.29099609
69MP0002970_abnormal_white_adipose1.28707654
70MP0005645_abnormal_hypothalamus_physiol1.28154812
71MP0005085_abnormal_gallbladder_physiolo1.26592096
72MP0008932_abnormal_embryonic_tissue1.26587316
73MP0005330_cardiomyopathy1.26284315
74MP0002139_abnormal_hepatobiliary_system1.23830136
75MP0001730_embryonic_growth_arrest1.22503208
76MP0002796_impaired_skin_barrier1.22190568
77MP0002277_abnormal_respiratory_mucosa1.19657664
78MP0005275_abnormal_skin_tensile1.18044601
79MP0003705_abnormal_hypodermis_morpholog1.17565930
80MP0003868_abnormal_feces_composition1.17063078
81MP0000749_muscle_degeneration1.16424384
82MP0002019_abnormal_tumor_incidence1.16372636
83MP0000350_abnormal_cell_proliferation1.15968086
84MP0001661_extended_life_span1.15451812
85MP0002876_abnormal_thyroid_physiology1.15245485
86MP0004087_abnormal_muscle_fiber1.12825926
87MP0005621_abnormal_cell_physiology1.11739212
88MP0001243_abnormal_dermal_layer1.10687871
89MP0002735_abnormal_chemical_nociception1.07921526
90MP0001853_heart_inflammation1.07847241
91MP0001881_abnormal_mammary_gland1.07738635
92MP0009931_abnormal_skin_appearance1.07267721
93MP0003787_abnormal_imprinting1.07250829
94MP0001873_stomach_inflammation1.06704699
95MP0004808_abnormal_hematopoietic_stem1.06626599
96MP0003941_abnormal_skin_development1.06171304
97MP0002080_prenatal_lethality1.05711961
98MP0000371_diluted_coat_color1.05700777
99MP0001727_abnormal_embryo_implantation1.05365913
100MP0000358_abnormal_cell_content/1.04696767
101MP0003656_abnormal_erythrocyte_physiolo1.04155112
102MP0002098_abnormal_vibrissa_morphology1.04025587
103MP0005551_abnormal_eye_electrophysiolog1.01924982
104MP0002332_abnormal_exercise_endurance1.01214658
105MP0001186_pigmentation_phenotype1.01085047
106MP0000026_abnormal_inner_ear1.00312290
107MP0005023_abnormal_wound_healing1.00108705
108MP0002396_abnormal_hematopoietic_system0.99610435
109MP0000733_abnormal_muscle_development0.99100357
110MP0002971_abnormal_brown_adipose0.98377417
111MP0003186_abnormal_redox_activity0.98028827
112MP0008438_abnormal_cutaneous_collagen0.98000929
113MP0004947_skin_inflammation0.97334399
114MP0001191_abnormal_skin_condition0.97243928
115MP0002095_abnormal_skin_pigmentation0.97225325
116MP0000313_abnormal_cell_death0.96566593
117MP0002009_preneoplasia0.96190381
118MP0000377_abnormal_hair_follicle0.95985720
119MP0000750_abnormal_muscle_regeneration0.95031387
120MP0000470_abnormal_stomach_morphology0.94887969
121MP0006035_abnormal_mitochondrial_morpho0.92956619
122MP0002075_abnormal_coat/hair_pigmentati0.92891990
123MP0005384_cellular_phenotype0.91966681
124MP0003938_abnormal_ear_development0.89598432
125MP0005501_abnormal_skin_physiology0.88755220
126MP0002089_abnormal_postnatal_growth/wei0.88684444
127MP0001216_abnormal_epidermal_layer0.88315638
128MP0010030_abnormal_orbit_morphology0.88082559
129MP0003937_abnormal_limbs/digits/tail_de0.87791756
130MP0005666_abnormal_adipose_tissue0.87659895
131MP0005266_abnormal_metabolism0.87257310
132MP0005257_abnormal_intraocular_pressure0.86210931
133MP0010352_gastrointestinal_tract_polyps0.85977527
134MP0001986_abnormal_taste_sensitivity0.85941319
135MP0000613_abnormal_salivary_gland0.85290233
136MP0000858_altered_metastatic_potential0.84847062
137MP0006072_abnormal_retinal_apoptosis0.84186943
138MP0000538_abnormal_urinary_bladder0.82344953
139MP0004142_abnormal_muscle_tone0.82011658
140MP0005171_absent_coat_pigmentation0.79801292
141MP0009115_abnormal_fat_cell0.79517630
142MP0003959_abnormal_lean_body0.79331260
143MP0002177_abnormal_outer_ear0.78965273
144MP0001348_abnormal_lacrimal_gland0.78289764
145MP0003984_embryonic_growth_retardation0.77051218
146MP0002234_abnormal_pharynx_morphology0.77029126
147MP0002168_other_aberrant_phenotype0.76845944
148MP0000013_abnormal_adipose_tissue0.76673743
149MP0006292_abnormal_olfactory_placode0.76393933
150MP0005248_abnormal_Harderian_gland0.76222080
151MP0003221_abnormal_cardiomyocyte_apopto0.75844966
152MP0000627_abnormal_mammary_gland0.75759617
153MP0003329_amyloid_beta_deposits0.75747186
154MP0009333_abnormal_splenocyte_physiolog0.74903992
155MP0010307_abnormal_tumor_latency0.72730511
156MP0000762_abnormal_tongue_morphology0.72296042
157MP0001764_abnormal_homeostasis0.71697995
158MP0001324_abnormal_eye_pigmentation0.71500102
159MP0003880_abnormal_central_pattern0.71319559
160MP0002067_abnormal_sensory_capabilities0.70769599
161MP0010630_abnormal_cardiac_muscle0.70659481
162MP0005380_embryogenesis_phenotype0.70518400
163MP0001672_abnormal_embryogenesis/_devel0.70518400
164MP0000604_amyloidosis0.70245680
165MP0001270_distended_abdomen0.69939856
166MP0005334_abnormal_fat_pad0.69553752
167MP0000467_abnormal_esophagus_morphology0.68237905
168MP0005623_abnormal_meninges_morphology0.67607672
169MP0008260_abnormal_autophagy0.66497254
170MP0005379_endocrine/exocrine_gland_phen0.66012890
171MP0001963_abnormal_hearing_physiology0.65861575
172MP0004133_heterotaxia0.63634765
173MP0000778_abnormal_nervous_system0.62195135
174MP0003011_delayed_dark_adaptation0.61705412
175MP0001340_abnormal_eyelid_morphology0.61609488
176MP0001879_abnormal_lymphatic_vessel0.60430874
177MP0001177_atelectasis0.60176446
178MP0010329_abnormal_lipoprotein_level0.60043951
179MP0000462_abnormal_digestive_system0.59824554
180MP0001501_abnormal_sleep_pattern0.59293140

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)6.15125308
2Chromsome breakage (HP:0040012)5.33272201
3Upper limb muscle weakness (HP:0003484)4.81036998
4Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.73883075
5Prostate neoplasm (HP:0100787)4.23834592
6Progressive muscle weakness (HP:0003323)3.88009301
7Abnormal respiratory motile cilium physiology (HP:0012261)3.84075747
8Distal lower limb muscle weakness (HP:0009053)3.83960252
9Abnormal ciliary motility (HP:0012262)3.79797191
10Ragged-red muscle fibers (HP:0003200)3.72769812
11Febrile seizures (HP:0002373)3.70254407
12Absent/shortened dynein arms (HP:0200106)3.66210553
13Dynein arm defect of respiratory motile cilia (HP:0012255)3.66210553
14Tubulointerstitial nephritis (HP:0001970)3.65657936
15Distal lower limb amyotrophy (HP:0008944)3.57248748
16Vertebral compression fractures (HP:0002953)3.55724100
17Duplicated collecting system (HP:0000081)3.45508461
18Abnormality of the renal collecting system (HP:0004742)3.12889672
19Entropion (HP:0000621)3.09247030
20Short nail (HP:0001799)2.93617013
21Abnormal respiratory motile cilium morphology (HP:0005938)2.91270523
22Abnormal respiratory epithelium morphology (HP:0012253)2.91270523
23Increased connective tissue (HP:0009025)2.89245496
24Submucous cleft hard palate (HP:0000176)2.88839716
25Hyperacusis (HP:0010780)2.80468766
26Alveolar cell carcinoma (HP:0006519)2.74398316
27Achilles tendon contracture (HP:0001771)2.72202118
28Lower limb amyotrophy (HP:0007210)2.68450143
29Conical tooth (HP:0000698)2.67599596
30Natal tooth (HP:0000695)2.63470008
31Bile duct proliferation (HP:0001408)2.61687797
32Abnormal biliary tract physiology (HP:0012439)2.61687797
33Neoplasm of the tracheobronchial system (HP:0100552)2.60175234
34Congenital stationary night blindness (HP:0007642)2.60045195
35Aplasia cutis congenita (HP:0001057)2.57845462
36Rhabdomyolysis (HP:0003201)2.56935970
37Abnormality of incisor morphology (HP:0011063)2.54607254
38Upper limb amyotrophy (HP:0009129)2.50800117
39Distal upper limb amyotrophy (HP:0007149)2.50800117
40Centrally nucleated skeletal muscle fibers (HP:0003687)2.48282903
41Premature rupture of membranes (HP:0001788)2.47319154
42Abnormality of glycolysis (HP:0004366)2.46630243
43Lip pit (HP:0100267)2.45297695
44J-shaped sella turcica (HP:0002680)2.41672131
45Abnormality of cells of the erythroid lineage (HP:0012130)2.40916039
46Cholecystitis (HP:0001082)2.40216525
47Abnormal gallbladder physiology (HP:0012438)2.40216525
48Abnormality of the Achilles tendon (HP:0005109)2.37001303
49Abnormal number of erythroid precursors (HP:0012131)2.36962736
50Renal cortical cysts (HP:0000803)2.35563359
51Poikiloderma (HP:0001029)2.35490563
52Chronic hepatic failure (HP:0100626)2.35303323
53Male pseudohermaphroditism (HP:0000037)2.34301086
54Onycholysis (HP:0001806)2.33058648
55Mesomelia (HP:0003027)2.32952305
56Fasciculations (HP:0002380)2.32856186
57Hypophosphatemic rickets (HP:0004912)2.31974488
58Abnormality of the preputium (HP:0100587)2.26890412
59Aplasia/Hypoplasia of the uvula (HP:0010293)2.26659031
60Selective tooth agenesis (HP:0001592)2.26396788
61Genetic anticipation (HP:0003743)2.24546338
62Protrusio acetabuli (HP:0003179)2.22150302
63Increased corneal curvature (HP:0100692)2.21093513
64Keratoconus (HP:0000563)2.21093513
65Rhinitis (HP:0012384)2.20983653
66Myoglobinuria (HP:0002913)2.20170710
67Bell-shaped thorax (HP:0001591)2.19671131
68Hypertensive crisis (HP:0100735)2.19173914
69Abnormality of nail color (HP:0100643)2.19024473
70Abnormality of DNA repair (HP:0003254)2.17229390
71Hand muscle atrophy (HP:0009130)2.16602216
72Abnormality of the prostate (HP:0008775)2.16261002
73Premature loss of primary teeth (HP:0006323)2.15927737
74Generalized amyotrophy (HP:0003700)2.15916758
75Seborrheic dermatitis (HP:0001051)2.14881670
76Fair hair (HP:0002286)2.14651473
77Elbow flexion contracture (HP:0002987)2.12011347
78Abnormality of the nasal septum (HP:0000419)2.10171838
79Pili torti (HP:0003777)2.10060398
80Squamous cell carcinoma (HP:0002860)2.09913345
81Congenital hepatic fibrosis (HP:0002612)2.09106746
82Testicular atrophy (HP:0000029)2.08438782
83Broad face (HP:0000283)2.07656217
84Trismus (HP:0000211)2.07570758
85Abnormality of the thoracic spine (HP:0100711)2.07345071
86Decreased number of peripheral myelinated nerve fibers (HP:0003380)2.07009420
87Increased serum pyruvate (HP:0003542)2.04707997
88Back pain (HP:0003418)2.04652967
89Abnormal hair laboratory examination (HP:0003328)2.03797877
90Abnormality of liposaccharide metabolism (HP:0010968)2.02849463
91Abnormality of glycosphingolipid metabolism (HP:0004343)2.02849463
92Abnormality of glycolipid metabolism (HP:0010969)2.02849463
93Decreased central vision (HP:0007663)2.02373133
94Insomnia (HP:0100785)2.00408087
95* Microvesicular hepatic steatosis (HP:0001414)1.99831625
96Thoracic kyphosis (HP:0002942)1.99035710
97Decreased motor nerve conduction velocity (HP:0003431)1.96551703
98Meckel diverticulum (HP:0002245)1.96408251
99Clubbing of toes (HP:0100760)1.95925266
100Abnormality of the renal cortex (HP:0011035)1.95161694
101Exercise-induced myalgia (HP:0003738)1.93679113
102Abnormality of the carotid arteries (HP:0005344)1.93591769
103Reticulocytosis (HP:0001923)1.92193777
104Postaxial foot polydactyly (HP:0001830)1.91120592
105Difficulty climbing stairs (HP:0003551)1.90855653
106Cervical subluxation (HP:0003308)1.90155678
107Acanthosis nigricans (HP:0000956)1.89716096
108Foot dorsiflexor weakness (HP:0009027)1.89478863
109Hepatosplenomegaly (HP:0001433)1.88453335
110Myopathic facies (HP:0002058)1.88155143
111Cellulitis (HP:0100658)1.87933486
112Ulnar bowing (HP:0003031)1.86956164
113Osteolytic defects of the phalanges of the hand (HP:0009771)1.85882810
114Osteolytic defects of the hand bones (HP:0009699)1.85882810
115Dry hair (HP:0011359)1.85407296
116Biconcave vertebral bodies (HP:0004586)1.84827206
117Abnormality of the renal medulla (HP:0100957)1.82718232
118Advanced eruption of teeth (HP:0006288)1.81676077
119Abnormality of the ileum (HP:0001549)1.81661851
120Absent speech (HP:0001344)1.81627960
121Congenital ichthyosiform erythroderma (HP:0007431)1.81335303
122Cholelithiasis (HP:0001081)1.78309530
123Hypokinesia (HP:0002375)1.78276147
124Conjugated hyperbilirubinemia (HP:0002908)1.77724496
125Duplication of thumb phalanx (HP:0009942)1.77685345
126Abnormality of the distal phalanges of the toes (HP:0010182)1.76996075
127Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.76468378
128Rough bone trabeculation (HP:0100670)1.75108221
129Broad distal phalanx of finger (HP:0009836)1.74718365
130Abnormality of the umbilical cord (HP:0010881)1.74698534
131Multiple enchondromatosis (HP:0005701)1.74539112
132Joint hemorrhage (HP:0005261)1.74225233
133Absent eyebrow (HP:0002223)1.73994032
134Abnormality of reticulocytes (HP:0004312)1.73759050
135Tubulointerstitial abnormality (HP:0001969)1.73447502
136Renal agenesis (HP:0000104)1.73040852
137Nephronophthisis (HP:0000090)1.72541256
138Milia (HP:0001056)1.71901576
139Ectopic kidney (HP:0000086)1.71476677
140Facial cleft (HP:0002006)1.71224040
141Long toe (HP:0010511)1.70606271
142Right ventricular cardiomyopathy (HP:0011663)1.70580785
143Axonal loss (HP:0003447)1.69645282
144Athetosis (HP:0002305)1.69310021
145Tetany (HP:0001281)1.69064583
146Cutaneous melanoma (HP:0012056)1.68331850
147Onion bulb formation (HP:0003383)1.67468997
148Nuclear cataract (HP:0100018)1.67322662
149Upper motor neuron abnormality (HP:0002127)1.67253175
150Increased IgE level (HP:0003212)1.67141571
151Long palpebral fissure (HP:0000637)1.66853831
152Colitis (HP:0002583)1.65486381
153Anal stenosis (HP:0002025)1.65431795
154Ventricular tachycardia (HP:0004756)1.65239290
155Nephroblastoma (Wilms tumor) (HP:0002667)1.65075274
156Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.64438088
157Polycystic kidney dysplasia (HP:0000113)1.64436288
158Abnormality of the antihelix (HP:0009738)1.64160476
159Sparse lateral eyebrow (HP:0005338)1.63736530
160Protruding tongue (HP:0010808)1.63113442
161Generalized hypopigmentation of hair (HP:0011358)1.62725420
162Mildly elevated creatine phosphokinase (HP:0008180)1.62679603
163Abnormality of the tricuspid valve (HP:0001702)1.62006086
164Hypoplasia of the iris (HP:0007676)1.61889559
165Increased serum ferritin (HP:0003281)1.61747197
166Hyperammonemia (HP:0001987)1.61645004
167Hyperthyroidism (HP:0000836)1.61169655
168Abnormality of the dental pulp (HP:0006479)1.60288019
169Spinal rigidity (HP:0003306)1.60132352
170Toxemia of pregnancy (HP:0100603)1.59638887
171Atrophic scars (HP:0001075)1.59277816
172Abnormality of the incisor (HP:0000676)1.59024529
173Abnormality of skeletal muscle fiber size (HP:0012084)1.58546400
174Pseudobulbar signs (HP:0002200)1.58388456
175Increased muscle lipid content (HP:0009058)1.58292633
176Abnormality of primary teeth (HP:0006481)1.57899099
177Ureteral duplication (HP:0000073)1.57762702
178Nonimmune hydrops fetalis (HP:0001790)1.57589689
179Abnormality of chromosome stability (HP:0003220)1.57375020
180Severe Myopia (HP:0011003)1.56525701
181Progressive cerebellar ataxia (HP:0002073)1.56493522
182Hypotelorism (HP:0000601)1.56092505
183Ectropion (HP:0000656)1.56039845
184Enlarged kidneys (HP:0000105)1.54261837
185Thick nail (HP:0001805)1.54025914
186Median cleft lip (HP:0000161)1.53058248
187Renovascular hypertension (HP:0100817)1.52451505
188Medial flaring of the eyebrow (HP:0010747)1.52145670
189Abnormality of pyrimidine metabolism (HP:0004353)1.52069044
190Hypoplasia of dental enamel (HP:0006297)1.51650083
191Gaze-evoked nystagmus (HP:0000640)1.50943660
192Septo-optic dysplasia (HP:0100842)1.50778558
193Hydroxyprolinuria (HP:0003080)1.50091538

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK4.06030792
2NME23.99674509
3EIF2AK23.77139417
4TRIB33.67913670
5CASK3.44378317
6SMG13.44068602
7TESK23.39220220
8CAMK1D3.16408515
9GRK13.16100187
10CAMK1G3.03828751
11INSRR2.91174344
12TESK12.69319948
13ERN12.67026456
14ZAK2.51123153
15VRK22.31833017
16LATS12.29089552
17PIM22.17726947
18TNIK2.09855452
19EEF2K2.09092069
20SCYL21.93026809
21BRD41.92096750
22MAP3K141.82465882
23NTRK31.80192242
24PBK1.69574163
25TTN1.65465286
26SIK11.64055931
27MKNK21.59610239
28CCNB11.59457504
29CDC71.56801932
30PKN21.56363877
31CDC42BPA1.55820230
32IRAK31.50797688
33SIK21.47258381
34PDK21.46816219
35MAP3K131.45959439
36NEK11.45145925
37FRK1.43732977
38KDR1.42322417
39CDK121.37325236
40BCKDK1.36826987
41PRKAA21.35514471
42BUB11.35492436
43PKN11.34930855
44MAP3K111.31223333
45RPS6KB21.29657076
46SGK21.28948694
47JAK11.27465609
48LIMK11.25039462
49EIF2AK31.16643394
50PINK11.16325568
51ARAF1.15157042
52TXK1.14555848
53MET1.13849254
54YES11.10867071
55CDK71.10756545
56AURKA1.08093159
57MTOR1.06675577
58TAOK31.02958686
59PIK3CG1.02031913
60CDK91.01577887
61LMTK21.01168209
62MUSK1.00313179
63PAK40.99236236
64STK160.99218057
65EPHA40.98953336
66TBK10.98292441
67CDK30.95257391
68SGK10.93921338
69NEK20.92551653
70NUAK10.90876999
71CDK80.90221436
72ABL20.89867811
73EIF2AK10.88466641
74NEK60.86646038
75LRRK20.86098241
76SGK30.85951374
77FGFR20.85212191
78MAP3K70.82954049
79TNK20.81407310
80AURKB0.80883505
81RIPK10.80717373
82MAPKAPK30.80489538
83EPHA20.79766739
84MAP2K30.78425937
85AKT30.78186115
86ATR0.77282059
87SRPK10.75935934
88TAOK20.75739302
89SGK2230.73661988
90SGK4940.73661988
91MST1R0.72952372
92PRKD20.72890762
93TLK10.72511698
94MAP2K70.72439240
95STK30.72432571
96CDK40.71189399
97MKNK10.70834039
98MAPK70.70274876
99CHEK10.69899918
100TRPM70.69050607
101MAPKAPK50.68341899
102MAP3K60.67239565
103DAPK20.66519682
104PDGFRA0.65944092
105BMPR1B0.65696059
106PTK20.64634244
107MAPK120.64164760
108MAPK150.63723358
109MAPK130.63542443
110AKT20.63412429
111PRKCQ0.61671806
112DAPK10.61624164
113FER0.60530642
114WNK10.58833098
115PRKCE0.58785667
116PIK3CA0.57655952
117TTK0.57156731
118RPS6KC10.56369427
119RPS6KL10.56369427
120FES0.55950607
121BMPR20.55431043
122RET0.55049441
123MAP3K80.54782299
124HCK0.54024984
125ADRBK20.53090095
126CAMK10.52826773
127BRAF0.51877943
128PRKAA10.50891830
129MAP2K20.49010568
130FLT30.49007969
131IRAK20.47987369
132EPHB20.47599632
133STK38L0.47128642
134PRPF4B0.47073530
135MAPK110.46916396
136EPHA30.46706423
137IKBKE0.46558852
138MARK20.46247042
139PRKG10.45597733
140CAMKK20.44677069
141STK100.44561141
142BMX0.44502623
143MELK0.44247949
144TYK20.43952534
145FGR0.43226535
146TEC0.41451620
147RPS6KA20.40938467
148DDR20.40323043
149STK110.40075727
150IRAK10.40007265
151PLK10.39976540
152OBSCN0.39834504
153ERBB20.39829292
154PRKCB0.39199725
155DAPK30.38558333
156MOS0.38092756
157PAK10.37974500
158IKBKB0.37353227
159ILK0.37174759
160RIPK40.36928496
161BRSK10.36811495
162RPS6KA40.36808498
163CAMK40.36770506
164WNK30.36683361
165RAF10.36489734
166PAK20.36378969
167JAK30.36333554
168PRKCG0.35933941
169MAPK100.35845504
170PNCK0.35653155
171IRAK40.35610396
172CDK60.35544863
173ABL10.35464952
174CHEK20.35043065
175PDPK10.33973109
176NME10.33945304
177RPS6KA60.33772518
178STK380.33618247
179CDK20.32540266
180MAPKAPK20.31190929
181STK40.28526270
182PRKD10.28263038
183CDK10.28182044

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.98554975
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.74019316
3Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.15061501
4Pentose phosphate pathway_Homo sapiens_hsa000303.07813680
5Base excision repair_Homo sapiens_hsa034103.03328890
6Other glycan degradation_Homo sapiens_hsa005112.98596884
7Biosynthesis of amino acids_Homo sapiens_hsa012302.97210319
8Fanconi anemia pathway_Homo sapiens_hsa034602.69916304
9Sulfur relay system_Homo sapiens_hsa041222.63630277
10Carbon metabolism_Homo sapiens_hsa012002.48547268
11Lysine degradation_Homo sapiens_hsa003102.45408822
12ABC transporters_Homo sapiens_hsa020102.35557712
13Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.21384503
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.14470969
15Steroid hormone biosynthesis_Homo sapiens_hsa001402.13549351
16Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.13070539
17beta-Alanine metabolism_Homo sapiens_hsa004101.98520790
18Phototransduction_Homo sapiens_hsa047441.94418917
19Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.91430840
20Nicotine addiction_Homo sapiens_hsa050331.86294722
21Fructose and mannose metabolism_Homo sapiens_hsa000511.84636586
22Retinol metabolism_Homo sapiens_hsa008301.79239680
23Nucleotide excision repair_Homo sapiens_hsa034201.75931963
24Tryptophan metabolism_Homo sapiens_hsa003801.75089855
25Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.74968113
26Pyruvate metabolism_Homo sapiens_hsa006201.74058379
27Vitamin digestion and absorption_Homo sapiens_hsa049771.73424320
28Propanoate metabolism_Homo sapiens_hsa006401.71438106
29Caffeine metabolism_Homo sapiens_hsa002321.70775034
30Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.66108175
31Mismatch repair_Homo sapiens_hsa034301.64412217
32Ovarian steroidogenesis_Homo sapiens_hsa049131.63038119
33Histidine metabolism_Homo sapiens_hsa003401.61751860
34Pyrimidine metabolism_Homo sapiens_hsa002401.59053278
35Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.52444388
36Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.52400845
37Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.52094134
38Phosphatidylinositol signaling system_Homo sapiens_hsa040701.51197794
39Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.50040459
40Dorso-ventral axis formation_Homo sapiens_hsa043201.49845994
41Fatty acid elongation_Homo sapiens_hsa000621.48480065
42Glycosaminoglycan degradation_Homo sapiens_hsa005311.47635466
43Spliceosome_Homo sapiens_hsa030401.46321132
44Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.45055894
45Primary bile acid biosynthesis_Homo sapiens_hsa001201.43748883
46Butanoate metabolism_Homo sapiens_hsa006501.41871656
47Sphingolipid metabolism_Homo sapiens_hsa006001.38853850
48Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.35250873
49Fatty acid biosynthesis_Homo sapiens_hsa000611.32562118
50Phenylalanine metabolism_Homo sapiens_hsa003601.31757988
51Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.28719734
52Inositol phosphate metabolism_Homo sapiens_hsa005621.28423947
53Fatty acid degradation_Homo sapiens_hsa000711.27838604
54Galactose metabolism_Homo sapiens_hsa000521.27378488
55Proteasome_Homo sapiens_hsa030501.24877581
56Taste transduction_Homo sapiens_hsa047421.23620581
57PPAR signaling pathway_Homo sapiens_hsa033201.23502735
58Fatty acid metabolism_Homo sapiens_hsa012121.22531751
59Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.22418117
60Cysteine and methionine metabolism_Homo sapiens_hsa002701.20323705
61Peroxisome_Homo sapiens_hsa041461.20181691
62One carbon pool by folate_Homo sapiens_hsa006701.19752539
63Bladder cancer_Homo sapiens_hsa052191.13112241
64NF-kappa B signaling pathway_Homo sapiens_hsa040641.11284678
65N-Glycan biosynthesis_Homo sapiens_hsa005101.09761698
66Calcium signaling pathway_Homo sapiens_hsa040201.08609701
67Cyanoamino acid metabolism_Homo sapiens_hsa004601.06797884
68Non-homologous end-joining_Homo sapiens_hsa034501.06466017
69Complement and coagulation cascades_Homo sapiens_hsa046101.05110288
70Vibrio cholerae infection_Homo sapiens_hsa051101.03769909
71Central carbon metabolism in cancer_Homo sapiens_hsa052301.03071603
72Cell cycle_Homo sapiens_hsa041101.02793885
73Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.99248003
74Type II diabetes mellitus_Homo sapiens_hsa049300.97587114
75Lysosome_Homo sapiens_hsa041420.97561100
76Folate biosynthesis_Homo sapiens_hsa007900.97478879
77Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.97364482
78Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.95390523
79alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.94231511
80Basal cell carcinoma_Homo sapiens_hsa052170.93556237
81Axon guidance_Homo sapiens_hsa043600.92933074
82Notch signaling pathway_Homo sapiens_hsa043300.92371350
83Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.91506909
84Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.89408520
85Morphine addiction_Homo sapiens_hsa050320.87139756
86Glutamatergic synapse_Homo sapiens_hsa047240.86255771
87Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.86145071
88ECM-receptor interaction_Homo sapiens_hsa045120.86126212
89Tyrosine metabolism_Homo sapiens_hsa003500.85756350
90Systemic lupus erythematosus_Homo sapiens_hsa053220.83879328
91Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.83706658
92Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.83174542
93RNA transport_Homo sapiens_hsa030130.82789805
94Glycerolipid metabolism_Homo sapiens_hsa005610.82052232
95Chronic myeloid leukemia_Homo sapiens_hsa052200.80498782
96Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.80174926
97Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.78805991
98Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.78637271
99Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.77447665
100Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.77224832
101Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.76580186
102Pentose and glucuronate interconversions_Homo sapiens_hsa000400.72713770
103Thyroid cancer_Homo sapiens_hsa052160.72587727
104Linoleic acid metabolism_Homo sapiens_hsa005910.72545416
105Chemical carcinogenesis_Homo sapiens_hsa052040.71310114
106AMPK signaling pathway_Homo sapiens_hsa041520.71268354
107Ribosome_Homo sapiens_hsa030100.70602423
108Non-small cell lung cancer_Homo sapiens_hsa052230.68985412
109Apoptosis_Homo sapiens_hsa042100.67997830
110Hedgehog signaling pathway_Homo sapiens_hsa043400.67557292
111Serotonergic synapse_Homo sapiens_hsa047260.67452515
112Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.65858552
113Steroid biosynthesis_Homo sapiens_hsa001000.65523503
114Glutathione metabolism_Homo sapiens_hsa004800.65421903
115Shigellosis_Homo sapiens_hsa051310.64330488
116Viral carcinogenesis_Homo sapiens_hsa052030.63369814
117Longevity regulating pathway - mammal_Homo sapiens_hsa042110.62648643
118Arginine biosynthesis_Homo sapiens_hsa002200.61214958
119ErbB signaling pathway_Homo sapiens_hsa040120.60731653
120Hepatitis C_Homo sapiens_hsa051600.60523127
121Choline metabolism in cancer_Homo sapiens_hsa052310.60152902
122VEGF signaling pathway_Homo sapiens_hsa043700.59282952
123Pancreatic cancer_Homo sapiens_hsa052120.57965667
124Glucagon signaling pathway_Homo sapiens_hsa049220.55073795
125Ras signaling pathway_Homo sapiens_hsa040140.54851081
126Staphylococcus aureus infection_Homo sapiens_hsa051500.54661912
127Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.54234551
128Prion diseases_Homo sapiens_hsa050200.54126653
129GnRH signaling pathway_Homo sapiens_hsa049120.53256307
130Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.53255469
131Melanoma_Homo sapiens_hsa052180.51450159
132Phospholipase D signaling pathway_Homo sapiens_hsa040720.51081646
133Small cell lung cancer_Homo sapiens_hsa052220.50121681
134Hematopoietic cell lineage_Homo sapiens_hsa046400.49779789
135HTLV-I infection_Homo sapiens_hsa051660.49437274
136Arachidonic acid metabolism_Homo sapiens_hsa005900.49326178
137Circadian entrainment_Homo sapiens_hsa047130.49315492
138Insulin signaling pathway_Homo sapiens_hsa049100.47826972
139Starch and sucrose metabolism_Homo sapiens_hsa005000.46258872
140Bile secretion_Homo sapiens_hsa049760.46192029
141Purine metabolism_Homo sapiens_hsa002300.45521161
142Renin secretion_Homo sapiens_hsa049240.44548125
143mTOR signaling pathway_Homo sapiens_hsa041500.44497027
144MicroRNAs in cancer_Homo sapiens_hsa052060.44350472
145cAMP signaling pathway_Homo sapiens_hsa040240.44343453
146Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.44293894
147Aldosterone synthesis and secretion_Homo sapiens_hsa049250.43841210
148Homologous recombination_Homo sapiens_hsa034400.43706653
149Metabolic pathways_Homo sapiens_hsa011000.43387459
150Olfactory transduction_Homo sapiens_hsa047400.43128732
151Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.42504962
152p53 signaling pathway_Homo sapiens_hsa041150.41527518
153Acute myeloid leukemia_Homo sapiens_hsa052210.40916363
154Intestinal immune network for IgA production_Homo sapiens_hsa046720.40551942
155Jak-STAT signaling pathway_Homo sapiens_hsa046300.40228580
156Salivary secretion_Homo sapiens_hsa049700.40120300
157Measles_Homo sapiens_hsa051620.39140269
158Epstein-Barr virus infection_Homo sapiens_hsa051690.38951756
159Dilated cardiomyopathy_Homo sapiens_hsa054140.38268939
160Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.38156255
161Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.37543888
162Arginine and proline metabolism_Homo sapiens_hsa003300.37380502
163Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.36334813
164Adipocytokine signaling pathway_Homo sapiens_hsa049200.36213871
165Thyroid hormone signaling pathway_Homo sapiens_hsa049190.36201976
166Drug metabolism - other enzymes_Homo sapiens_hsa009830.36025695
167Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.34383260
168Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.33609833
169RNA polymerase_Homo sapiens_hsa030200.31029203
170Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.29415390
171Salmonella infection_Homo sapiens_hsa051320.27868181
172mRNA surveillance pathway_Homo sapiens_hsa030150.27603447
173Endometrial cancer_Homo sapiens_hsa052130.26678318
174Hepatitis B_Homo sapiens_hsa051610.26426580
175Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.24821491
176Parkinsons disease_Homo sapiens_hsa050120.24350160
177Vitamin B6 metabolism_Homo sapiens_hsa007500.24024788

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