ACADM

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the medium-chain specific (C4 to C12 straight chain) acyl-Coenzyme A dehydrogenase. The homotetramer enzyme catalyzes the initial step of the mitochondrial fatty acid beta-oxidation pathway. Defects in this gene cause medium-chain acyl-CoA dehydrogenase deficiency, a disease characterized by hepatic dysfunction, fasting hypoglycemia, and encephalopathy, which can result in infantile death. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1lysine metabolic process (GO:0006553)6.53849051
2lysine catabolic process (GO:0006554)6.53849051
3muscle filament sliding (GO:0030049)6.26689221
4actin-myosin filament sliding (GO:0033275)6.26689221
5* fatty acid beta-oxidation (GO:0006635)5.49132215
62-oxoglutarate metabolic process (GO:0006103)5.40601045
7glyoxylate metabolic process (GO:0046487)5.37312567
8tricarboxylic acid cycle (GO:0006099)5.24878305
9erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.21940369
10L-phenylalanine catabolic process (GO:0006559)5.21940369
11actin-mediated cell contraction (GO:0070252)5.20341383
12erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.18256724
13L-phenylalanine metabolic process (GO:0006558)5.18256724
14carnitine shuttle (GO:0006853)5.16650664
15fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.15161143
16fatty acid transmembrane transport (GO:1902001)5.15150629
17sarcoplasmic reticulum calcium ion transport (GO:0070296)5.13617051
18* fatty acid oxidation (GO:0019395)4.99330418
19aspartate family amino acid catabolic process (GO:0009068)4.98695336
20valine metabolic process (GO:0006573)4.98132310
21acetyl-CoA metabolic process (GO:0006084)4.96631403
22branched-chain amino acid catabolic process (GO:0009083)4.92600587
23* lipid oxidation (GO:0034440)4.90025248
24short-chain fatty acid metabolic process (GO:0046459)4.86756258
25* fatty acid catabolic process (GO:0009062)4.83612837
26aromatic amino acid family catabolic process (GO:0009074)4.82237012
27synapsis (GO:0007129)4.79048173
28kynurenine metabolic process (GO:0070189)4.75061856
29cysteine metabolic process (GO:0006534)4.73800562
30cellular ketone body metabolic process (GO:0046950)4.73416869
31branched-chain amino acid metabolic process (GO:0009081)4.72454757
32regulation of sequestering of triglyceride (GO:0010889)4.71413292
33alpha-linolenic acid metabolic process (GO:0036109)4.67811280
34biotin metabolic process (GO:0006768)4.62797831
35regulation of relaxation of muscle (GO:1901077)4.53295335
36carnitine transport (GO:0015879)4.52518184
37amino-acid betaine transport (GO:0015838)4.52518184
38* amino-acid betaine metabolic process (GO:0006577)4.52367171
39NADH metabolic process (GO:0006734)4.50652644
40tricarboxylic acid metabolic process (GO:0072350)4.48168925
41indole-containing compound catabolic process (GO:0042436)4.47155391
42indolalkylamine catabolic process (GO:0046218)4.47155391
43tryptophan catabolic process (GO:0006569)4.47155391
44positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.46754358
45regulation of skeletal muscle contraction (GO:0014819)4.43297397
46* monocarboxylic acid catabolic process (GO:0072329)4.40525645
47serine family amino acid catabolic process (GO:0009071)4.33099834
48carnitine transmembrane transport (GO:1902603)4.29654190
49sulfur amino acid catabolic process (GO:0000098)4.28234194
50oxidative phosphorylation (GO:0006119)4.25809266
51regulation of triglyceride catabolic process (GO:0010896)4.21444518
52tryptophan metabolic process (GO:0006568)4.20482202
53triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.16117543
54quaternary ammonium group transport (GO:0015697)4.12878723
55homocysteine metabolic process (GO:0050667)4.11982030
56regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.08293181
57ketone body metabolic process (GO:1902224)4.06922800
58regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.04835349
59skeletal muscle contraction (GO:0003009)4.04344880
60regulation of fatty acid oxidation (GO:0046320)4.02943556
61bile acid biosynthetic process (GO:0006699)4.01547273
62* carnitine metabolic process (GO:0009437)3.97982703
63ethanol oxidation (GO:0006069)3.96188028
64alpha-amino acid catabolic process (GO:1901606)3.96080986
65positive regulation of fatty acid beta-oxidation (GO:0032000)3.93947610
66* carboxylic acid catabolic process (GO:0046395)3.89770418
67* organic acid catabolic process (GO:0016054)3.89770418
68creatine metabolic process (GO:0006600)3.88074474
69drug transmembrane transport (GO:0006855)3.87083389
70succinate metabolic process (GO:0006105)3.86355509
71cellular amino acid catabolic process (GO:0009063)3.84238248
72urate metabolic process (GO:0046415)3.83341521
73mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.81281889
74positive regulation of fatty acid oxidation (GO:0046321)3.80886204
75sarcomere organization (GO:0045214)3.78177795
76myofibril assembly (GO:0030239)3.73088481
77oxaloacetate metabolic process (GO:0006107)3.73083756
78heart process (GO:0003015)3.69770491
79heart contraction (GO:0060047)3.69770491
80regulation of acyl-CoA biosynthetic process (GO:0050812)3.63022842
81regulation of actin filament-based movement (GO:1903115)3.62582079
82striated muscle contraction (GO:0006941)3.61545152
83response to mercury ion (GO:0046689)3.58660513
84aromatic amino acid family metabolic process (GO:0009072)3.57418349
85actin filament-based movement (GO:0030048)3.52531224
86serine family amino acid metabolic process (GO:0009069)3.52435948
87triglyceride homeostasis (GO:0070328)3.50545327
88acylglycerol homeostasis (GO:0055090)3.50545327
89urea cycle (GO:0000050)3.49756232
90urea metabolic process (GO:0019627)3.49756232
91negative regulation of fatty acid biosynthetic process (GO:0045717)3.48691710
92IMP metabolic process (GO:0046040)3.45527289
93glutamate metabolic process (GO:0006536)3.43493516
94negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.42836961
95phospholipid homeostasis (GO:0055091)3.42408340
96cellular modified amino acid catabolic process (GO:0042219)3.40885784
97dicarboxylic acid biosynthetic process (GO:0043650)3.40491674
98bile acid metabolic process (GO:0008206)3.39415980
99thioester metabolic process (GO:0035383)3.38099828
100acyl-CoA metabolic process (GO:0006637)3.38099828
101regulation of fatty acid beta-oxidation (GO:0031998)3.36106142
102positive regulation of lipid catabolic process (GO:0050996)3.34835960
103regulation of cell communication by electrical coupling (GO:0010649)3.32834465
104plasma lipoprotein particle clearance (GO:0034381)3.32321048
105regulation of cholesterol metabolic process (GO:0090181)3.31832197
106regulation of coenzyme metabolic process (GO:0051196)3.31418067
107regulation of cofactor metabolic process (GO:0051193)3.31418067
108nitrogen cycle metabolic process (GO:0071941)3.30106969
109cardiac muscle contraction (GO:0060048)3.29711139
110glycogen catabolic process (GO:0005980)3.29610647
111piRNA metabolic process (GO:0034587)3.29152223
112benzene-containing compound metabolic process (GO:0042537)3.26948926
113response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.26797813
114* small molecule catabolic process (GO:0044282)3.26779481
115complement activation, alternative pathway (GO:0006957)3.25682701
116glycine metabolic process (GO:0006544)3.25204205
117drug transport (GO:0015893)3.23918176
118respiratory electron transport chain (GO:0022904)3.22782938
119regulation of DNA endoreduplication (GO:0032875)3.20711202
120dicarboxylic acid metabolic process (GO:0043648)3.20216629
121cardiac myofibril assembly (GO:0055003)3.20097293
122negative regulation of potassium ion transmembrane transport (GO:1901380)3.19852679
123mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.19402457
124coenzyme catabolic process (GO:0009109)3.16867720
125drug catabolic process (GO:0042737)3.16706462
126peptidyl-glutamic acid carboxylation (GO:0017187)3.13956027
127protein carboxylation (GO:0018214)3.13956027
128regulation of meiosis I (GO:0060631)3.13301606
129NAD metabolic process (GO:0019674)3.12401400
130tyrosine metabolic process (GO:0006570)3.11425807
131electron transport chain (GO:0022900)3.11316251
132fatty acid homeostasis (GO:0055089)3.10362601
133negative regulation of fibrinolysis (GO:0051918)3.07828849
134thioester biosynthetic process (GO:0035384)3.07345596
135glucan catabolic process (GO:0009251)3.04854960
136IMP biosynthetic process (GO:0006188)3.04534729
137somatic hypermutation of immunoglobulin genes (GO:0016446)3.03465500
138somatic diversification of immune receptors via somatic mutation (GO:0002566)3.03465500
139regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.99695632
140aerobic respiration (GO:0009060)2.96160669
141resolution of meiotic recombination intermediates (GO:0000712)2.93024198
142ATP synthesis coupled proton transport (GO:0015986)2.89957831
143energy coupled proton transport, down electrochemical gradient (GO:0015985)2.89957831
144AMP metabolic process (GO:0046033)2.88813088
145* glucan biosynthetic process (GO:0009250)2.88627154
146* glycogen biosynthetic process (GO:0005978)2.88627154
147cellular polysaccharide catabolic process (GO:0044247)2.88144453
148proteasome assembly (GO:0043248)2.85410698
149regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.82007216
150CENP-A containing nucleosome assembly (GO:0034080)2.79173760
151gluconeogenesis (GO:0006094)2.78978242
152ubiquinone biosynthetic process (GO:0006744)2.78196704
153cellular respiration (GO:0045333)2.77971816
154chromatin remodeling at centromere (GO:0031055)2.77209428
155quinone biosynthetic process (GO:1901663)2.74566083
156response to muscle activity (GO:0014850)2.74533661
157regulation of sulfur metabolic process (GO:0042762)2.74524103
158chromosome organization involved in meiosis (GO:0070192)2.73804959
159xenobiotic catabolic process (GO:0042178)2.71675850
160exogenous drug catabolic process (GO:0042738)2.67209937
161negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.66887155
162cardiac muscle hypertrophy (GO:0003300)2.65894094
163polysaccharide catabolic process (GO:0000272)2.63652091
164meiotic chromosome segregation (GO:0045132)2.59062527
165striated muscle hypertrophy (GO:0014897)2.58718370
166actomyosin structure organization (GO:0031032)2.55345370
167cullin deneddylation (GO:0010388)2.54594702
168mitotic sister chromatid cohesion (GO:0007064)2.50200575
169ubiquinone metabolic process (GO:0006743)2.49589993

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.41975286
2* PPARG_19300518_ChIP-PET_3T3-L1_Mouse8.93334727
3* RXR_22158963_ChIP-Seq_LIVER_Mouse6.62806564
4* PPARA_22158963_ChIP-Seq_LIVER_Mouse5.94066380
5E2F7_22180533_ChIP-Seq_HELA_Human5.28762774
6* LXR_22158963_ChIP-Seq_LIVER_Mouse5.21543179
7* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse4.54024798
8EGR1_23403033_ChIP-Seq_LIVER_Mouse4.34901688
9FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.13268108
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.99133116
11CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.52014154
12NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.43773635
13IGF1R_20145208_ChIP-Seq_DFB_Human3.12710926
14E2F4_17652178_ChIP-ChIP_JURKAT_Human3.00640461
15ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.72374302
16EST1_17652178_ChIP-ChIP_JURKAT_Human2.67057457
17GABP_17652178_ChIP-ChIP_JURKAT_Human2.65909588
18CLOCK_20551151_ChIP-Seq_293T_Human2.65243360
19CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.64644908
20MYC_18555785_ChIP-Seq_MESCs_Mouse2.52480020
21CREB1_15753290_ChIP-ChIP_HEK293T_Human2.44089264
22HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.28320955
23ZNF263_19887448_ChIP-Seq_K562_Human2.16031538
24PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.15291373
25MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.12951954
26ELK1_19687146_ChIP-ChIP_HELA_Human2.10213435
27TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.08496637
28POU3F2_20337985_ChIP-ChIP_501MEL_Human2.03373186
29* RARG_19884340_ChIP-ChIP_MEFs_Mouse1.99882010
30CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.98464545
31JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.92749662
32KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.91043757
33NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.90784325
34VDR_23849224_ChIP-Seq_CD4+_Human1.88403678
35FLI1_27457419_Chip-Seq_LIVER_Mouse1.87305835
36FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.87274272
37TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.83889422
38RBPJ_22232070_ChIP-Seq_NCS_Mouse1.76602784
39FUS_26573619_Chip-Seq_HEK293_Human1.73648590
40GATA1_22025678_ChIP-Seq_K562_Human1.73180015
41ETS1_20019798_ChIP-Seq_JURKAT_Human1.70775112
42HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.70336488
43VDR_22108803_ChIP-Seq_LS180_Human1.67740939
44* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.66653529
45TBX20_22080862_ChIP-Seq_HEART_Mouse1.62200645
46TBX20_22328084_ChIP-Seq_HEART_Mouse1.62200645
47STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.60993995
48FOXP3_21729870_ChIP-Seq_TREG_Human1.59855188
49EWS_26573619_Chip-Seq_HEK293_Human1.56909105
50YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.56701708
51PADI4_21655091_ChIP-ChIP_MCF-7_Human1.55794431
52MYC_18358816_ChIP-ChIP_MESCs_Mouse1.53533410
53HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.51306908
54RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.50235775
55E2F1_21310950_ChIP-Seq_MCF-7_Human1.47904849
56* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.47679740
57SALL1_21062744_ChIP-ChIP_HESCs_Human1.44206408
58MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.43566065
59FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.42375170
60EP300_21415370_ChIP-Seq_HL-1_Mouse1.41150080
61GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40066920
62DCP1A_22483619_ChIP-Seq_HELA_Human1.39182081
63STAT3_1855785_ChIP-Seq_MESCs_Mouse1.38657837
64PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.38128610
65PCGF2_27294783_Chip-Seq_ESCs_Mouse1.37306414
66TAF15_26573619_Chip-Seq_HEK293_Human1.37040128
67PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.34680834
68FOXA2_19822575_ChIP-Seq_HepG2_Human1.34577767
69THAP11_20581084_ChIP-Seq_MESCs_Mouse1.33007064
70MYC_19079543_ChIP-ChIP_MESCs_Mouse1.30923564
71* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.30117982
72HOXB4_20404135_ChIP-ChIP_EML_Mouse1.29970335
73TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.29465843
74PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.27902110
75EZH2_27294783_Chip-Seq_NPCs_Mouse1.27022711
76MYCN_18555785_ChIP-Seq_MESCs_Mouse1.25251409
77PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.25105863
78ESR2_21235772_ChIP-Seq_MCF-7_Human1.24731467
79THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.24653498
80* HNF4A_19822575_ChIP-Seq_HepG2_Human1.23282391
81ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.22207655
82* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.21898286
83ESR1_20079471_ChIP-ChIP_T-47D_Human1.21728674
84* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.21610404
85ZFX_18555785_ChIP-Seq_MESCs_Mouse1.20411789
86SUZ12_27294783_Chip-Seq_NPCs_Mouse1.19111537
87HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.18358717
88NFE2_27457419_Chip-Seq_LIVER_Mouse1.16438732
89TTF2_22483619_ChIP-Seq_HELA_Human1.15788653
90PPAR_26484153_Chip-Seq_NCI-H1993_Human1.13015376
91MYC_18940864_ChIP-ChIP_HL60_Human1.11411105
92SOX2_27498859_Chip-Seq_STOMACH_Mouse1.08347321
93* PHF8_20622853_ChIP-Seq_HELA_Human1.06720274
94NANOG_19829295_ChIP-Seq_ESCs_Human1.06464637
95SOX2_19829295_ChIP-Seq_ESCs_Human1.06464637
96SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.06201152
97CRX_20693478_ChIP-Seq_RETINA_Mouse1.05360501
98ESR1_21235772_ChIP-Seq_MCF-7_Human1.05194454
99PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.04044385
100* CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.01892156
101E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.00813697
102ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.00589936
103FOXM1_23109430_ChIP-Seq_U2OS_Human0.98060119
104* RBPJ_21746931_ChIP-Seq_IB4_Human0.97799851
105FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.97672895
106SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.97613995
107* GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.97335767
108POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.97158297
109POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.96467199
110SALL4_22934838_ChIP-ChIP_CD34+_Human0.96238009
111PCGF2_27294783_Chip-Seq_NPCs_Mouse0.95813202
112CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.94600822
113ZFP57_27257070_Chip-Seq_ESCs_Mouse0.93554115
114CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.93432629
115* GATA4_25053715_ChIP-Seq_YYC3_Human0.93394930
116* GATA6_21074721_ChIP-Seq_CACO-2_Human0.92367815
117NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.91920047
118* PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.91789691
119* ETV1_20927104_ChIP-Seq_GIST48_Human0.91506059
120GATA4_21415370_ChIP-Seq_HL-1_Mouse0.91441857
121ER_23166858_ChIP-Seq_MCF-7_Human0.90490905
122KLF5_20875108_ChIP-Seq_MESCs_Mouse0.90403416
123AUTS2_25519132_ChIP-Seq_293T-REX_Human0.89996453
124* HNFA_21074721_ChIP-Seq_CACO-2_Human0.89581591
125SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.89580322
126NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.87664693
127TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.87375402
128* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.86716115
129SALL4_18804426_ChIP-ChIP_XEN_Mouse0.85922466
130CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.82255940
131BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.81031541
132STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.80844703
133IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.80499163
134RXRA_24833708_ChIP-Seq_LIVER_Mouse0.79809221
135MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.76212436
136TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.76092005
137FOXO3_23340844_ChIP-Seq_DLD1_Human0.74780125
138BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.73320882
139CEBPB_22108803_ChIP-Seq_LS180_Human0.73223524
140RACK7_27058665_Chip-Seq_MCF-7_Human0.70932072
141ATF3_27146783_Chip-Seq_COLON_Human0.69435635
142* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.68692399
143BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.68526996
144GATA1_19941826_ChIP-Seq_K562_Human0.67785922
145ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.67384237
146GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.66453233
147SRF_21415370_ChIP-Seq_HL-1_Mouse0.65993728
148EGR1_19032775_ChIP-ChIP_M12_Human0.65893874
149HTT_18923047_ChIP-ChIP_STHdh_Human0.65544247
150TRIM28_21343339_ChIP-Seq_HEK293_Human0.65488158
151LXR_22292898_ChIP-Seq_THP-1_Human0.63872058
152AR_21909140_ChIP-Seq_LNCAP_Human0.63243822
153SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.63133799
154SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.62686390
155GATA2_19941826_ChIP-Seq_K562_Human0.62616169
156GATA6_25053715_ChIP-Seq_YYC3_Human0.61873557
157RAD21_21589869_ChIP-Seq_MESCs_Mouse0.61338791
158BCOR_27268052_Chip-Seq_Bcells_Human0.60584299
159* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.60102945
160PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.59659618
161POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.58788011
162GATA3_24758297_ChIP-Seq_MCF-7_Human0.58656440
163RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.57816592
164NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.57420178
165NRF2_20460467_ChIP-Seq_MEFs_Mouse0.57420178
166SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.57155074
167SOX2_18692474_ChIP-Seq_MEFs_Mouse0.55979442
168CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.55200990
169TAF2_19829295_ChIP-Seq_ESCs_Human0.55042371
170CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.54142772
171AR_20517297_ChIP-Seq_VCAP_Human0.53778357
172EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.53459040
173RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.52397798
174FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.52062564
175RAC3_21632823_ChIP-Seq_H3396_Human0.51962892
176PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.51583895
177* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.51561627
178CSB_26484114_Chip-Seq_FIBROBLAST_Human0.51226193
179ERG_20517297_ChIP-Seq_VCAP_Human0.51196834
180GATA1_19941827_ChIP-Seq_MEL_Mouse0.51100820
181P68_20966046_ChIP-Seq_HELA_Human0.51095548

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.66329234
2MP0005360_urolithiasis5.57912124
3MP0004145_abnormal_muscle_electrophysio4.70250307
4MP0005365_abnormal_bile_salt4.22002816
5MP0005085_abnormal_gallbladder_physiolo4.16421581
6MP0002837_dystrophic_cardiac_calcinosis3.77619031
7MP0003806_abnormal_nucleotide_metabolis3.35937039
8MP0008875_abnormal_xenobiotic_pharmacok3.35350451
9MP0003646_muscle_fatigue3.29809944
10MP0005670_abnormal_white_adipose2.93289695
11* MP0005332_abnormal_amino_acid2.89472355
12MP0010329_abnormal_lipoprotein_level2.68373770
13MP0004130_abnormal_muscle_cell2.67149491
14MP0003195_calcinosis2.64650976
15MP0004084_abnormal_cardiac_muscle2.60758865
16MP0003252_abnormal_bile_duct2.52358683
17MP0010094_abnormal_chromosome_stability2.36235820
18MP0009840_abnormal_foam_cell2.29871592
19MP0005666_abnormal_adipose_tissue2.27507680
20MP0008058_abnormal_DNA_repair2.27413608
21MP0003191_abnormal_cellular_cholesterol2.24281398
22MP0004215_abnormal_myocardial_fiber2.22221358
23MP0006036_abnormal_mitochondrial_physio2.18904211
24MP0000751_myopathy2.11714042
25* MP0005330_cardiomyopathy2.05932024
26MP0004036_abnormal_muscle_relaxation2.03633690
27MP0004019_abnormal_vitamin_homeostasis2.02209658
28MP0008057_abnormal_DNA_replication1.94597127
29MP0002118_abnormal_lipid_homeostasis1.93756528
30MP0005319_abnormal_enzyme/_coenzyme1.83369475
31MP0009643_abnormal_urine_homeostasis1.80723427
32MP0004043_abnormal_pH_regulation1.79265975
33MP0000749_muscle_degeneration1.69014057
34MP0005083_abnormal_biliary_tract1.68532837
35MP0008877_abnormal_DNA_methylation1.67926434
36MP0000372_irregular_coat_pigmentation1.67769519
37MP0001666_abnormal_nutrient_absorption1.66199367
38* MP0000609_abnormal_liver_physiology1.66091422
39MP0005584_abnormal_enzyme/coenzyme_acti1.58984637
40MP0003186_abnormal_redox_activity1.58162977
41MP0008775_abnormal_heart_ventricle1.57027574
42MP0005451_abnormal_body_composition1.55972606
43MP0002972_abnormal_cardiac_muscle1.51339058
44MP0002971_abnormal_brown_adipose1.47339764
45MP0005385_cardiovascular_system_phenoty1.46708210
46MP0001544_abnormal_cardiovascular_syste1.46708210
47* MP0004087_abnormal_muscle_fiber1.46627025
48MP0004957_abnormal_blastocyst_morpholog1.42228051
49MP0002138_abnormal_hepatobiliary_system1.41571387
50MP0004185_abnormal_adipocyte_glucose1.40320681
51MP0006138_congestive_heart_failure1.35430936
52MP0003221_abnormal_cardiomyocyte_apopto1.34623073
53MP0003693_abnormal_embryo_hatching1.34617835
54MP0005620_abnormal_muscle_contractility1.34074944
55MP0002269_muscular_atrophy1.32568991
56MP0005375_adipose_tissue_phenotype1.31692280
57MP0001764_abnormal_homeostasis1.31368813
58MP0000750_abnormal_muscle_regeneration1.27211104
59MP0001756_abnormal_urination1.26445088
60MP0003111_abnormal_nucleus_morphology1.26224204
61* MP0010630_abnormal_cardiac_muscle1.25484589
62MP0002009_preneoplasia1.22899109
63MP0003718_maternal_effect1.21844843
64MP0006035_abnormal_mitochondrial_morpho1.21831812
65MP0003077_abnormal_cell_cycle1.13313640
66MP0003705_abnormal_hypodermis_morpholog1.11648366
67MP0000747_muscle_weakness1.10983287
68MP0003137_abnormal_impulse_conducting1.10972836
69MP0004484_altered_response_of1.07618856
70MP0005636_abnormal_mineral_homeostasis1.06512214
71* MP0005535_abnormal_body_temperature1.02374730
72MP0001661_extended_life_span0.99528383
73MP0005266_abnormal_metabolism0.99393338
74MP0002106_abnormal_muscle_physiology0.98691600
75MP0005334_abnormal_fat_pad0.98221236
76* MP0002078_abnormal_glucose_homeostasis0.97494597
77MP0000230_abnormal_systemic_arterial0.95781812
78MP0002332_abnormal_exercise_endurance0.94258818
79MP0010368_abnormal_lymphatic_system0.93048961
80MP0006072_abnormal_retinal_apoptosis0.91688616
81MP0005645_abnormal_hypothalamus_physiol0.89856015
82MP0003828_pulmonary_edema0.89457744
83MP0002136_abnormal_kidney_physiology0.87626747
84MP0000598_abnormal_liver_morphology0.87436765
85MP0001929_abnormal_gametogenesis0.87231312
86MP0009115_abnormal_fat_cell0.87043702
87MP0002210_abnormal_sex_determination0.86678735
88MP0002102_abnormal_ear_morphology0.83715615
89MP0001765_abnormal_ion_homeostasis0.80210647
90MP0001730_embryonic_growth_arrest0.79683156
91MP0008007_abnormal_cellular_replicative0.79483219
92MP0000013_abnormal_adipose_tissue0.78327459
93MP0000759_abnormal_skeletal_muscle0.76989620
94MP0000343_altered_response_to0.76799797
95MP0005369_muscle_phenotype0.76266125
96MP0004085_abnormal_heartbeat0.74932226
97MP0003656_abnormal_erythrocyte_physiolo0.74505359
98* MP0009642_abnormal_blood_homeostasis0.74406730
99MP0005376_homeostasis/metabolism_phenot0.74043151
100MP0004147_increased_porphyrin_level0.73071696
101MP0005165_increased_susceptibility_to0.71884839
102MP0009763_increased_sensitivity_to0.71870928
103MP0002876_abnormal_thyroid_physiology0.71862949
104MP0001145_abnormal_male_reproductive0.70409335
105MP0002166_altered_tumor_susceptibility0.69985274
106MP0003868_abnormal_feces_composition0.68784690
107MP0008995_early_reproductive_senescence0.68601986
108MP0002970_abnormal_white_adipose0.67823638
109MP0000653_abnormal_sex_gland0.67389098
110MP0002638_abnormal_pupillary_reflex0.66482641
111MP0001529_abnormal_vocalization0.65406302
112MP0003698_abnormal_male_reproductive0.64752674
113MP0005647_abnormal_sex_gland0.64706725
114MP0008469_abnormal_protein_level0.64258279
115MP0008932_abnormal_embryonic_tissue0.63754324
116MP0003011_delayed_dark_adaptation0.63343706
117MP0009672_abnormal_birth_weight0.60726041
118MP0002822_catalepsy0.60493326
119MP0009697_abnormal_copulation0.59770077
120MP0001984_abnormal_olfaction0.59589769
121MP0002127_abnormal_cardiovascular_syste0.59146804
122MP0005253_abnormal_eye_physiology0.59083985
123MP0005058_abnormal_lysosome_morphology0.58956272
124MP0009764_decreased_sensitivity_to0.58763314
125MP0005448_abnormal_energy_balance0.57879671
126MP0001853_heart_inflammation0.56390647
127MP0003567_abnormal_fetal_cardiomyocyte0.56371640
128MP0008961_abnormal_basal_metabolism0.55880367
129MP0004233_abnormal_muscle_weight0.54981330
130MP0005084_abnormal_gallbladder_morpholo0.54502397
131MP0000003_abnormal_adipose_tissue0.53537243
132* MP0000266_abnormal_heart_morphology0.53206403
133MP0000604_amyloidosis0.52023868

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber inclusion bodies (HP:0100299)6.94396985
2Nemaline bodies (HP:0003798)6.83513424
3Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)6.61179247
4* Hyperglycinuria (HP:0003108)4.97999436
5Hypoglycemic coma (HP:0001325)4.84669909
6* Abnormality of fatty-acid metabolism (HP:0004359)4.73072055
7Ketosis (HP:0001946)4.69838361
8Hyperammonemia (HP:0001987)4.67301681
9Ketoacidosis (HP:0001993)4.62105113
10* Abnormality of serine family amino acid metabolism (HP:0010894)4.47098330
11* Abnormality of glycine metabolism (HP:0010895)4.47098330
12Rimmed vacuoles (HP:0003805)4.41907077
13Hyperglycinemia (HP:0002154)4.32232534
14Myoglobinuria (HP:0002913)4.23576257
15* Abnormality of dicarboxylic acid metabolism (HP:0010995)4.07483787
16* Dicarboxylic aciduria (HP:0003215)4.07483787
17Xanthomatosis (HP:0000991)4.02591072
18Abnormality of aromatic amino acid family metabolism (HP:0004338)4.00581890
19Type 1 muscle fiber predominance (HP:0003803)4.00237072
20Generalized aminoaciduria (HP:0002909)3.88591794
21Intrahepatic cholestasis (HP:0001406)3.79400631
22Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.74107684
23EMG: myopathic abnormalities (HP:0003458)3.71638551
24Proximal tubulopathy (HP:0000114)3.64667336
25Abnormality of glutamine family amino acid metabolism (HP:0010902)3.62597689
26Gout (HP:0001997)3.62216110
27Rhabdomyolysis (HP:0003201)3.53195494
28Distal arthrogryposis (HP:0005684)3.50702581
29Sudden death (HP:0001699)3.49588893
30Deep venous thrombosis (HP:0002625)3.49585210
31Hyperlipoproteinemia (HP:0010980)3.44934435
32Hepatic necrosis (HP:0002605)3.34848335
33Abnormality of monocarboxylic acid metabolism (HP:0010996)3.29657339
34Hypoalphalipoproteinemia (HP:0003233)3.27145600
35Abnormality of aspartate family amino acid metabolism (HP:0010899)3.22340073
36Ventricular tachycardia (HP:0004756)3.19154923
37Abnormality of serum amino acid levels (HP:0003112)3.11646558
38* Lethargy (HP:0001254)3.10739385
39Exercise-induced myalgia (HP:0003738)3.10230288
40Nausea (HP:0002018)3.09936134
41Subaortic stenosis (HP:0001682)3.09423464
42Abnormality of the left ventricular outflow tract (HP:0011103)3.09423464
43Increased purine levels (HP:0004368)3.05881757
44Hyperuricemia (HP:0002149)3.05881757
45Abnormality of purine metabolism (HP:0004352)3.03515337
46* Metabolic acidosis (HP:0001942)3.02565410
47* Cerebral edema (HP:0002181)3.00644496
48Neck muscle weakness (HP:0000467)2.99344308
49Hypolipoproteinemia (HP:0010981)2.97846107
50Muscle fiber splitting (HP:0003555)2.93537477
51Increased muscle lipid content (HP:0009058)2.91974063
52Hypobetalipoproteinemia (HP:0003563)2.90876988
53Exercise-induced muscle cramps (HP:0003710)2.90815818
54Palpitations (HP:0001962)2.89548083
55Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.84757416
56Right ventricular cardiomyopathy (HP:0011663)2.79768963
57Acute encephalopathy (HP:0006846)2.79044336
58Abnormality of sulfur amino acid metabolism (HP:0004339)2.76186674
59Myopathic facies (HP:0002058)2.76098546
60Prolonged partial thromboplastin time (HP:0003645)2.74790661
61Delayed CNS myelination (HP:0002188)2.74263600
62Exercise intolerance (HP:0003546)2.69583840
63* Vomiting (HP:0002013)2.69074774
64Complement deficiency (HP:0004431)2.67938195
65Epidermoid cyst (HP:0200040)2.65974846
66Lipoatrophy (HP:0100578)2.65263088
67Glycosuria (HP:0003076)2.63465195
68Abnormality of urine glucose concentration (HP:0011016)2.63465195
69Increased CSF lactate (HP:0002490)2.61471739
70Progressive macrocephaly (HP:0004481)2.61414940
71Abnormality of nucleobase metabolism (HP:0010932)2.58544168
72Calf muscle hypertrophy (HP:0008981)2.56985204
73Mitochondrial inheritance (HP:0001427)2.50817304
74Centrally nucleated skeletal muscle fibers (HP:0003687)2.47642942
75Renal cortical cysts (HP:0000803)2.47541552
76Dilated cardiomyopathy (HP:0001644)2.43428459
77Absent phalangeal crease (HP:0006109)2.43251673
78Abnormality of proline metabolism (HP:0010907)2.42360418
79Hydroxyprolinuria (HP:0003080)2.42360418
80Atrioventricular block (HP:0001678)2.39379849
81Lactic acidosis (HP:0003128)2.37096996
82Hepatocellular necrosis (HP:0001404)2.36549147
83Abnormality of methionine metabolism (HP:0010901)2.36080886
84Shoulder girdle muscle weakness (HP:0003547)2.35655298
85Frequent falls (HP:0002359)2.34269201
86Atrial fibrillation (HP:0005110)2.32638484
87Methylmalonic aciduria (HP:0012120)2.32273237
88Calcaneovalgus deformity (HP:0001848)2.32133420
89Increased serum pyruvate (HP:0003542)2.31690017
90Abnormality of glycolysis (HP:0004366)2.31690017
91Muscle stiffness (HP:0003552)2.31409656
92Hyporeflexia of lower limbs (HP:0002600)2.31356718
93Muscle hypertrophy of the lower extremities (HP:0008968)2.28817228
94Lipid accumulation in hepatocytes (HP:0006561)2.25559051
95Abnormal mitochondria in muscle tissue (HP:0008316)2.24120223
96Increased connective tissue (HP:0009025)2.21901428
97Increased hepatocellular lipid droplets (HP:0006565)2.20981378
98Joint hemorrhage (HP:0005261)2.19100106
99Skin nodule (HP:0200036)2.17260385
100Syncope (HP:0001279)2.14290496
101Myotonia (HP:0002486)2.13956069
102Increased intramyocellular lipid droplets (HP:0012240)2.13284075
103Asymmetric septal hypertrophy (HP:0001670)2.12085270
104Ragged-red muscle fibers (HP:0003200)2.11905478
105Hyperinsulinemic hypoglycemia (HP:0000825)2.11614450
106Areflexia of lower limbs (HP:0002522)2.10331605
107Hyperbilirubinemia (HP:0002904)2.09749374
108Primary atrial arrhythmia (HP:0001692)2.09548268
109Hypercholesterolemia (HP:0003124)2.09465408
110Progressive muscle weakness (HP:0003323)2.09088864
111Reduced antithrombin III activity (HP:0001976)2.05844917
112Increased serum lactate (HP:0002151)2.05654333
113Conjunctival hamartoma (HP:0100780)2.05590820
114Heart block (HP:0012722)2.05340095
115Abnormality of the common coagulation pathway (HP:0010990)2.04859952
116Acute necrotizing encephalopathy (HP:0006965)2.04554138
117EMG: neuropathic changes (HP:0003445)2.04200316
118Fat malabsorption (HP:0002630)2.03696293
119Decreased activity of mitochondrial respiratory chain (HP:0008972)2.02770826
120Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.02770826
121Supraventricular tachycardia (HP:0004755)2.02057468
122Abnormal finger flexion creases (HP:0006143)2.01845371
123Late onset (HP:0003584)2.01630765
124Abnormal cartilage morphology (HP:0002763)2.01304907
125Abnormality of skeletal muscle fiber size (HP:0012084)2.01229074
126Hyperglycemia (HP:0003074)2.01038493
127Difficulty running (HP:0009046)2.00740533
128Deformed tarsal bones (HP:0008119)2.00387898
129Bundle branch block (HP:0011710)1.99944736
130Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.99773953
131Abnormality of alanine metabolism (HP:0010916)1.99773953
132Hyperalaninemia (HP:0003348)1.99773953
133Supraventricular arrhythmia (HP:0005115)1.98645895
134Abnormality of the calf musculature (HP:0001430)1.98256062
135Respiratory failure (HP:0002878)1.96644314
136Gonadotropin excess (HP:0000837)1.96105423
137Generalized muscle weakness (HP:0003324)1.96017263
138Alkalosis (HP:0001948)1.95529507
139Round ear (HP:0100830)1.89981624
140Volvulus (HP:0002580)1.81023908
141Long clavicles (HP:0000890)1.75736499

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.45499685
2PDK44.17892353
3PDK34.17892353
4TTN3.26634975
5TRIB33.13038112
6EIF2AK32.79518158
7BRSK22.78687246
8PDK22.77808506
9PKN22.68308076
10WEE12.57303150
11ACVR1B2.52550818
12LMTK22.45573048
13WNK42.45353198
14OBSCN2.44936841
15NEK12.38876420
16MYLK2.28859540
17PINK12.26983949
18TIE12.18405972
19WNK32.16838744
20PBK2.09661839
21SIK12.08317874
22PHKG12.07488148
23PHKG22.07488148
24PLK42.02108665
25FGFR41.96123962
26EIF2AK11.95624860
27CCNB11.95292573
28CDC71.91955252
29TTK1.88414810
30STK38L1.83498622
31PNCK1.82143407
32MST41.78759231
33BUB11.77298741
34INSRR1.75981088
35CDK191.73451088
36ERN11.73242430
37VRK21.57482334
38FLT31.55927169
39PIK3CA1.41819597
40PRKAA21.39732233
41VRK11.36989142
42OXSR11.36187476
43NEK91.29003955
44BMPR1B1.28650411
45TAF11.28444334
46MKNK11.28002640
47ERBB31.24234921
48MAP2K31.24038160
49NME11.20920297
50CAMK1D1.20637108
51SCYL21.19927122
52SRPK11.16796426
53MST1R1.14169668
54PRKAA11.11880577
55STK161.09294645
56STK241.08488174
57MAP3K71.07457419
58LATS11.03716044
59TGFBR21.03465920
60NUAK11.03057819
61MAP3K31.02997533
62PLK11.02934970
63MKNK21.01551953
64KDR0.99613028
65RIPK10.98841784
66MUSK0.98001871
67MAPK110.96502315
68PLK30.96438001
69MAPK120.87070316
70PASK0.83594562
71GRK70.83154175
72EIF2AK20.80405302
73STK390.80149366
74BRSK10.77684113
75PIK3CG0.74584432
76NME20.74171017
77PAK30.73108602
78PRKD10.72895651
79DMPK0.71970708
80ABL20.71153283
81MAPKAPK50.70967070
82PDPK10.69139215
83PTK60.67940666
84ATR0.66447414
85RPS6KB20.65785357
86MAP3K40.64900258
87PRKACG0.63266555
88STK30.63226239
89TYK20.61648852
90TNIK0.61175045
91MAP3K50.59733528
92STK380.59347542
93AURKB0.57436552
94SGK30.56082318
95ATM0.55815396
96JAK20.55119918
97MAPKAPK30.55055068
98EPHB10.54803094
99MAP4K20.52197439
100MAP2K40.51792410
101TSSK60.51527530
102PDK10.51041649
103STK40.50723562
104ILK0.50436768
105CSNK2A20.50421405
106CAMK2D0.49809309
107PRKG10.49671070
108CAMK1G0.48694631
109ERBB40.48533362
110LRRK20.48220046
111JAK10.44529615
112ZAK0.44438545
113CHEK10.41532034
114SGK2230.41492346
115SGK4940.41492346
116GSK3A0.41217072
117CDK30.40436673
118PDGFRA0.40336776
119CSNK2A10.40287935
120CAMK40.40015019
121MET0.39699658
122AKT20.39262755
123IRAK30.38995104
124MAP3K110.38730198
125PRKDC0.38275983
126CHEK20.37925398
127TBK10.37874799
128SGK20.36805660
129CAMK2G0.36036904
130ROCK10.35885322
131MAPK40.35575312
132PLK20.35327565
133KIT0.33956752
134MTOR0.32209662
135RAF10.31925317
136MAP2K10.30650005
137CAMK2A0.30425502
138PRKACB0.30277942
139GRK10.30272947
140RPS6KB10.30253589
141PRKACA0.29235751
142CDK40.28628204
143MAP3K100.28126597
144FRK0.27994058
145MAP2K60.26336689
146DYRK30.25624483
147TRPM70.24706978
148WNK10.24674800
149RPS6KA30.23923746
150FGFR30.23174014
151TEC0.22745165
152CSNK1G10.22649628
153DAPK30.21847299
154CDK20.21548639
155CDK60.20425767
156PRKG20.20368843
157DYRK1B0.17288154
158FER0.17239674
159IGF1R0.16334569
160PKN10.16229230

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.55248366
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.50539381
3* Propanoate metabolism_Homo sapiens_hsa006403.48846818
4* Fatty acid degradation_Homo sapiens_hsa000713.42835912
5* Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.38651331
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006303.15048113
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.97388760
8Primary bile acid biosynthesis_Homo sapiens_hsa001202.71520533
9Butanoate metabolism_Homo sapiens_hsa006502.68990824
10* Fatty acid metabolism_Homo sapiens_hsa012122.65875165
11Tryptophan metabolism_Homo sapiens_hsa003802.44408558
12Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.38654216
13Nitrogen metabolism_Homo sapiens_hsa009102.30601868
14* PPAR signaling pathway_Homo sapiens_hsa033202.23825293
15Arginine biosynthesis_Homo sapiens_hsa002202.21244663
16Pyruvate metabolism_Homo sapiens_hsa006202.21128855
17Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.18070889
18Peroxisome_Homo sapiens_hsa041462.17855159
19Mismatch repair_Homo sapiens_hsa034302.17094586
20* Carbon metabolism_Homo sapiens_hsa012002.16406157
21Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.15468308
22Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.98670470
23Pentose and glucuronate interconversions_Homo sapiens_hsa000401.83276091
24Fatty acid elongation_Homo sapiens_hsa000621.81029853
25Proteasome_Homo sapiens_hsa030501.79312579
26DNA replication_Homo sapiens_hsa030301.76545771
27Non-homologous end-joining_Homo sapiens_hsa034501.75617277
28* beta-Alanine metabolism_Homo sapiens_hsa004101.74206068
29Biosynthesis of amino acids_Homo sapiens_hsa012301.48387684
30Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.41245263
31Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.40710677
32Complement and coagulation cascades_Homo sapiens_hsa046101.36234198
33Starch and sucrose metabolism_Homo sapiens_hsa005001.31661480
34Homologous recombination_Homo sapiens_hsa034401.31282729
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.26562961
36Phenylalanine metabolism_Homo sapiens_hsa003601.26428227
37Protein export_Homo sapiens_hsa030601.23955290
38Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.23631220
39Chemical carcinogenesis_Homo sapiens_hsa052041.21838052
40Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.21315434
41Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.15944251
42Histidine metabolism_Homo sapiens_hsa003401.15847601
43Nucleotide excision repair_Homo sapiens_hsa034201.14651671
44Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.14420041
45Bile secretion_Homo sapiens_hsa049761.13794348
46Sulfur metabolism_Homo sapiens_hsa009201.13706314
47Caffeine metabolism_Homo sapiens_hsa002321.13566247
48Cysteine and methionine metabolism_Homo sapiens_hsa002701.10726659
49Selenocompound metabolism_Homo sapiens_hsa004501.08582107
50Drug metabolism - other enzymes_Homo sapiens_hsa009831.07766456
51Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.05716307
52Tyrosine metabolism_Homo sapiens_hsa003501.05686917
53Base excision repair_Homo sapiens_hsa034101.04489478
54RNA transport_Homo sapiens_hsa030131.03292263
55Arginine and proline metabolism_Homo sapiens_hsa003301.02392192
56Cyanoamino acid metabolism_Homo sapiens_hsa004601.02139327
57Lysine degradation_Homo sapiens_hsa003101.01848441
58Fatty acid biosynthesis_Homo sapiens_hsa000611.01277844
59Steroid hormone biosynthesis_Homo sapiens_hsa001401.00511011
60Retinol metabolism_Homo sapiens_hsa008300.99592070
61Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.98489041
62Fat digestion and absorption_Homo sapiens_hsa049750.98007836
63RNA degradation_Homo sapiens_hsa030180.97942063
64Glycerolipid metabolism_Homo sapiens_hsa005610.97858223
65Oxidative phosphorylation_Homo sapiens_hsa001900.97690014
66Ribosome_Homo sapiens_hsa030100.96855266
67Parkinsons disease_Homo sapiens_hsa050120.93235592
68Folate biosynthesis_Homo sapiens_hsa007900.89083463
69Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.88363376
70Fanconi anemia pathway_Homo sapiens_hsa034600.86421550
71Vitamin digestion and absorption_Homo sapiens_hsa049770.83989510
72Glutathione metabolism_Homo sapiens_hsa004800.82577790
73Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.82431370
74Cardiac muscle contraction_Homo sapiens_hsa042600.78367627
75Pentose phosphate pathway_Homo sapiens_hsa000300.77161990
76Staphylococcus aureus infection_Homo sapiens_hsa051500.76276665
77ABC transporters_Homo sapiens_hsa020100.75904958
78Circadian rhythm_Homo sapiens_hsa047100.73442342
79Sulfur relay system_Homo sapiens_hsa041220.72939660
80Purine metabolism_Homo sapiens_hsa002300.72816871
81Vitamin B6 metabolism_Homo sapiens_hsa007500.70689091
82Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.70533203
83Adipocytokine signaling pathway_Homo sapiens_hsa049200.66814341
84Spliceosome_Homo sapiens_hsa030400.66728021
85Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.65257176
86Fructose and mannose metabolism_Homo sapiens_hsa000510.63741198
87Cell cycle_Homo sapiens_hsa041100.63660953
88* Metabolic pathways_Homo sapiens_hsa011000.58912471
89Basal transcription factors_Homo sapiens_hsa030220.57820173
90RNA polymerase_Homo sapiens_hsa030200.57808548
91Insulin resistance_Homo sapiens_hsa049310.57316653
92Alzheimers disease_Homo sapiens_hsa050100.55061735
93Oocyte meiosis_Homo sapiens_hsa041140.51155901
94Pyrimidine metabolism_Homo sapiens_hsa002400.50317104
95Galactose metabolism_Homo sapiens_hsa000520.45025526
96Huntingtons disease_Homo sapiens_hsa050160.42838471
97AMPK signaling pathway_Homo sapiens_hsa041520.42045954
98Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.41868126
99Asthma_Homo sapiens_hsa053100.40744265
100Systemic lupus erythematosus_Homo sapiens_hsa053220.40355668
101Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.40313439
102Dilated cardiomyopathy_Homo sapiens_hsa054140.38837317
103Glucagon signaling pathway_Homo sapiens_hsa049220.37925824
104mRNA surveillance pathway_Homo sapiens_hsa030150.34436526
105Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.32133175
106Maturity onset diabetes of the young_Homo sapiens_hsa049500.25120830
107Insulin signaling pathway_Homo sapiens_hsa049100.24764846
108Steroid biosynthesis_Homo sapiens_hsa001000.23262102
109alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.22370281
110Glycerophospholipid metabolism_Homo sapiens_hsa005640.22183282
111One carbon pool by folate_Homo sapiens_hsa006700.17494996
112Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.12610402
113Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.12050931
114Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.08364747
115Linoleic acid metabolism_Homo sapiens_hsa005910.05889643
116Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.03115135
117Central carbon metabolism in cancer_Homo sapiens_hsa052300.02722475
118Arachidonic acid metabolism_Homo sapiens_hsa005900.02339862
119Protein digestion and absorption_Homo sapiens_hsa049740.01925706
120Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0979118
121Mineral absorption_Homo sapiens_hsa04978-0.0921991
122Viral myocarditis_Homo sapiens_hsa05416-0.0642525
123Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0570754
124Renin-angiotensin system_Homo sapiens_hsa04614-0.0401645
125Regulation of autophagy_Homo sapiens_hsa04140-0.0317241
126Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.0086787

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