ACADS

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a tetrameric mitochondrial flavoprotein, which is a member of the acyl-CoA dehydrogenase family. This enzyme catalyzes the initial step of the mitochondrial fatty acid beta-oxidation pathway. Mutations in this gene have been associated with short-chain acyl-CoA dehydrogenase (SCAD) deficiency. Alternative splicing results in two variants which encode different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1NADH metabolic process (GO:0006734)6.45515204
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.17155078
3L-phenylalanine catabolic process (GO:0006559)6.17155078
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.12596305
5L-phenylalanine metabolic process (GO:0006558)6.12596305
6lysine catabolic process (GO:0006554)5.70173585
7lysine metabolic process (GO:0006553)5.70173585
8glyoxylate metabolic process (GO:0046487)5.66699637
9aromatic amino acid family catabolic process (GO:0009074)5.52693737
10triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.28451206
11alpha-linolenic acid metabolic process (GO:0036109)5.27711112
12sulfur amino acid catabolic process (GO:0000098)5.21391493
13kynurenine metabolic process (GO:0070189)5.20509934
14fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.14724052
15cysteine metabolic process (GO:0006534)5.01571919
16tryptophan catabolic process (GO:0006569)4.97838049
17indole-containing compound catabolic process (GO:0042436)4.97838049
18indolalkylamine catabolic process (GO:0046218)4.97838049
19amino-acid betaine metabolic process (GO:0006577)4.85544428
20bile acid biosynthetic process (GO:0006699)4.82325907
21serine family amino acid catabolic process (GO:0009071)4.80544485
22epoxygenase P450 pathway (GO:0019373)4.77482345
23regulation of triglyceride catabolic process (GO:0010896)4.73760835
24tryptophan metabolic process (GO:0006568)4.69910341
25angiotensin maturation (GO:0002003)4.66802562
26* fatty acid beta-oxidation (GO:0006635)4.65613815
27cellular ketone body metabolic process (GO:0046950)4.62064937
282-oxoglutarate metabolic process (GO:0006103)4.61246079
29urea metabolic process (GO:0019627)4.57987128
30urea cycle (GO:0000050)4.57987128
31homocysteine metabolic process (GO:0050667)4.45608112
32acetyl-CoA metabolic process (GO:0006084)4.45003511
33complement activation, alternative pathway (GO:0006957)4.42785200
34negative regulation of fibrinolysis (GO:0051918)4.42530070
35* fatty acid oxidation (GO:0019395)4.36801267
36fatty acid transmembrane transport (GO:1902001)4.32291777
37fructose metabolic process (GO:0006000)4.31604546
38positive regulation of triglyceride lipase activity (GO:0061365)4.30621380
39valine metabolic process (GO:0006573)4.30392563
40oxaloacetate metabolic process (GO:0006107)4.30256313
41alpha-amino acid catabolic process (GO:1901606)4.27546566
42high-density lipoprotein particle remodeling (GO:0034375)4.27212351
43* lipid oxidation (GO:0034440)4.27196780
44aspartate family amino acid catabolic process (GO:0009068)4.25757659
45nitrogen cycle metabolic process (GO:0071941)4.25173427
46protein carboxylation (GO:0018214)4.25157785
47peptidyl-glutamic acid carboxylation (GO:0017187)4.25157785
48regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)4.22547366
49* fatty acid catabolic process (GO:0009062)4.22201664
50regulation of protein activation cascade (GO:2000257)4.21650002
51ethanol oxidation (GO:0006069)4.21488609
52creatine metabolic process (GO:0006600)4.21241441
53carnitine metabolic process (GO:0009437)4.14586279
54carnitine shuttle (GO:0006853)4.13843980
55bile acid metabolic process (GO:0008206)4.12821811
56glycine metabolic process (GO:0006544)4.12765279
57acylglycerol homeostasis (GO:0055090)4.11512558
58triglyceride homeostasis (GO:0070328)4.11512558
59regulation of fibrinolysis (GO:0051917)4.09486475
60aromatic amino acid family metabolic process (GO:0009072)4.07446764
61cellular amino acid catabolic process (GO:0009063)4.07068668
62* monocarboxylic acid catabolic process (GO:0072329)4.03390353
63positive regulation of fatty acid beta-oxidation (GO:0032000)4.01756586
64branched-chain amino acid catabolic process (GO:0009083)4.00997151
65plasma lipoprotein particle clearance (GO:0034381)3.99950750
66ketone body metabolic process (GO:1902224)3.98935270
67regulation of complement activation (GO:0030449)3.97477156
68serine family amino acid metabolic process (GO:0009069)3.97233184
69biotin metabolic process (GO:0006768)3.90964948
70fat-soluble vitamin biosynthetic process (GO:0042362)3.89983349
71cellular modified amino acid catabolic process (GO:0042219)3.89602940
72* organic acid catabolic process (GO:0016054)3.86441447
73* carboxylic acid catabolic process (GO:0046395)3.86441447
74negative regulation of cholesterol transport (GO:0032375)3.84530569
75negative regulation of sterol transport (GO:0032372)3.84530569
76branched-chain amino acid metabolic process (GO:0009081)3.84382844
77diacylglycerol metabolic process (GO:0046339)3.83434366
78regulation of sequestering of triglyceride (GO:0010889)3.82727718
79* short-chain fatty acid metabolic process (GO:0046459)3.82598883
80tyrosine metabolic process (GO:0006570)3.78424809
81reverse cholesterol transport (GO:0043691)3.75508769
82protein-lipid complex remodeling (GO:0034368)3.75063481
83macromolecular complex remodeling (GO:0034367)3.75063481
84plasma lipoprotein particle remodeling (GO:0034369)3.75063481
85coenzyme catabolic process (GO:0009109)3.74750177
86ethanol metabolic process (GO:0006067)3.74519275
87positive regulation of lipid catabolic process (GO:0050996)3.73889980
88tricarboxylic acid metabolic process (GO:0072350)3.70245265
89phospholipid homeostasis (GO:0055091)3.69075229
90regulation of cholesterol esterification (GO:0010872)3.68885383
91exogenous drug catabolic process (GO:0042738)3.67402418
92glutamate metabolic process (GO:0006536)3.66070169
93regulation of cholesterol homeostasis (GO:2000188)3.65860444
94negative regulation of fatty acid biosynthetic process (GO:0045717)3.65107546
95serine family amino acid biosynthetic process (GO:0009070)3.65057191
96dicarboxylic acid biosynthetic process (GO:0043650)3.64613290
97positive regulation of fatty acid oxidation (GO:0046321)3.63141951
98cellular glucuronidation (GO:0052695)3.59462475
99regulation of fatty acid beta-oxidation (GO:0031998)3.57415024
100regulation of fatty acid oxidation (GO:0046320)3.55444614
101phospholipid efflux (GO:0033700)3.55443090
102drug catabolic process (GO:0042737)3.55377515
103benzene-containing compound metabolic process (GO:0042537)3.54957120
104tricarboxylic acid cycle (GO:0006099)3.54212188
105drug metabolic process (GO:0017144)3.53385065
106drug transmembrane transport (GO:0006855)3.48905237
107bile acid and bile salt transport (GO:0015721)3.46317011
108indolalkylamine metabolic process (GO:0006586)3.43846041
109muscle filament sliding (GO:0030049)3.41756822
110actin-myosin filament sliding (GO:0033275)3.41756822
111urate metabolic process (GO:0046415)3.39902607
112regulation of cholesterol metabolic process (GO:0090181)3.38954801
113carnitine transport (GO:0015879)3.37093291
114amino-acid betaine transport (GO:0015838)3.37093291
115positive regulation of lipoprotein lipase activity (GO:0051006)3.36359713
116positive regulation of fatty acid biosynthetic process (GO:0045723)3.28677869
117intestinal absorption (GO:0050892)3.26243259
118triglyceride catabolic process (GO:0019433)3.12131509
119low-density lipoprotein particle clearance (GO:0034383)3.09750927
120very-low-density lipoprotein particle assembly (GO:0034379)3.07864659
121quinone biosynthetic process (GO:1901663)2.96335996
122skeletal muscle contraction (GO:0003009)2.95357392
123protein-lipid complex assembly (GO:0065005)2.94499333
124neutral lipid catabolic process (GO:0046461)2.92402245
125acylglycerol catabolic process (GO:0046464)2.92402245
126positive regulation of triglyceride metabolic process (GO:0090208)2.90302344
127regulation of fatty acid biosynthetic process (GO:0042304)2.86419233
128lipoprotein transport (GO:0042953)2.86279158
129regulation of guanylate cyclase activity (GO:0031282)2.86264034
130sarcoplasmic reticulum calcium ion transport (GO:0070296)2.82717704
131arginine metabolic process (GO:0006525)2.82490828
132gluconeogenesis (GO:0006094)2.82311607
133hormone catabolic process (GO:0042447)2.81925317
134complement activation, classical pathway (GO:0006958)2.81839640
135uronic acid metabolic process (GO:0006063)2.79995748
136glucuronate metabolic process (GO:0019585)2.79995748
137plasma lipoprotein particle assembly (GO:0034377)2.78092880
138succinate metabolic process (GO:0006105)2.77596288
139actin-mediated cell contraction (GO:0070252)2.75260903
140transcytosis (GO:0045056)2.73970686
141antigen processing and presentation of endogenous antigen (GO:0019883)2.71336248
142glycosphingolipid catabolic process (GO:0046479)2.70469700
143complement activation (GO:0006956)2.70156711
144omega-hydroxylase P450 pathway (GO:0097267)2.70066739
145protein-lipid complex subunit organization (GO:0071825)2.69578798
146nucleoside diphosphate biosynthetic process (GO:0009133)2.68698289
147regulation of cholesterol storage (GO:0010885)2.64153144
148glucan catabolic process (GO:0009251)2.62912842
149glycolipid catabolic process (GO:0019377)2.61158774
150positive regulation of fatty acid metabolic process (GO:0045923)2.59735335
151plasma lipoprotein particle organization (GO:0071827)2.59503175
152hexose biosynthetic process (GO:0019319)2.59126818
153polyketide metabolic process (GO:0030638)2.56976234
154doxorubicin metabolic process (GO:0044598)2.56976234
155daunorubicin metabolic process (GO:0044597)2.56976234
156regulation of systemic arterial blood pressure by hormone (GO:0001990)2.56057791
157endocrine process (GO:0050886)2.56057791

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.92976723
2* PPARG_19300518_ChIP-PET_3T3-L1_Mouse7.28567384
3RXR_22158963_ChIP-Seq_LIVER_Mouse6.98254761
4PPARA_22158963_ChIP-Seq_LIVER_Mouse6.27808984
5LXR_22158963_ChIP-Seq_LIVER_Mouse5.33691371
6EGR1_23403033_ChIP-Seq_LIVER_Mouse4.90272014
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.21784847
8BP1_19119308_ChIP-ChIP_Hs578T_Human4.04417682
9CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.00994889
10* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.48415157
11NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.36418591
12CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.99562703
13CLOCK_20551151_ChIP-Seq_293T_Human2.31130298
14HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.10533223
15ZNF263_19887448_ChIP-Seq_K562_Human1.86339109
16TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.84569338
17RARG_19884340_ChIP-ChIP_MEFs_Mouse1.82919671
18* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.73269408
19TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.69195907
20VDR_24763502_ChIP-Seq_THP-1_Human1.66050689
21STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.64942311
22MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.51487914
23STAT3_1855785_ChIP-Seq_MESCs_Mouse1.48000132
24PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.41844384
25* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.41571484
26KDM2B_26808549_Chip-Seq_SUP-B15_Human1.41180327
27SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.40856461
28THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.38542820
29* SA1_27219007_Chip-Seq_ERYTHROID_Human1.36884641
30ELF1_20517297_ChIP-Seq_JURKAT_Human1.35580779
31STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.34861881
32* SA1_27219007_Chip-Seq_Bcells_Human1.34708393
33KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.33675186
34E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.31570835
35GATA1_22025678_ChIP-Seq_K562_Human1.31234560
36CTCF_27219007_Chip-Seq_ERYTHROID_Human1.29662667
37PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.28092157
38SRY_22984422_ChIP-ChIP_TESTIS_Rat1.26825899
39GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.26605513
40FOXA2_19822575_ChIP-Seq_HepG2_Human1.25645720
41TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.24872609
42NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.24695221
43MAF_26560356_Chip-Seq_TH1_Human1.23767805
44CTCF_27219007_Chip-Seq_Bcells_Human1.23452181
45* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.22963332
46LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.22737869
47DNAJC2_21179169_ChIP-ChIP_NT2_Human1.22207108
48* HNF4A_19822575_ChIP-Seq_HepG2_Human1.21487401
49GATA2_22383799_ChIP-Seq_G1ME_Mouse1.21432899
50* TCF7_22412390_ChIP-Seq_EML_Mouse1.21040251
51LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.20507646
52SMC4_20622854_ChIP-Seq_HELA_Human1.18251906
53KDM2B_26808549_Chip-Seq_DND41_Human1.16768145
54MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.16515773
55PU.1_20513432_ChIP-Seq_Bcells_Mouse1.14044055
56CTCF_26484167_Chip-Seq_Bcells_Mouse1.13583017
57LXR_22292898_ChIP-Seq_THP-1_Human1.13416284
58CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.13252372
59RUNX1_22412390_ChIP-Seq_EML_Mouse1.13019794
60SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.12971150
61SOX2_27498859_Chip-Seq_STOMACH_Mouse1.12139441
62CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.12028721
63IRF8_21731497_ChIP-ChIP_J774_Mouse1.11977951
64ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.11351036
65CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10061953
66UTX_26944678_Chip-Seq_JUKART_Human1.09645685
67STAT1_20625510_ChIP-Seq_HELA_Human1.07719064
68SCL_19346495_ChIP-Seq_HPC-7_Human1.07406863
69MYC_22102868_ChIP-Seq_BL_Human1.07302397
70NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.07264999
71ETS1_21867929_ChIP-Seq_TH2_Mouse1.07008595
72YY1_22570637_ChIP-Seq_MALME-3M_Human1.06600827
73* E2F1_20622854_ChIP-Seq_HELA_Human1.06489346
74PHF8_20622854_ChIP-Seq_HELA_Human1.06470645
75RXRA_24833708_ChIP-Seq_LIVER_Mouse1.05614814
76ERG_21242973_ChIP-ChIP_JURKAT_Human1.03732773
77PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.03697872
78MAF_26560356_Chip-Seq_TH2_Human1.03233646
79PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01764294
80STAT4_19710469_ChIP-ChIP_TH1__Mouse1.01177764
81ESR1_15608294_ChIP-ChIP_MCF-7_Human0.98569206
82SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.98307470
83TBX20_22328084_ChIP-Seq_HEART_Mouse0.98136849
84TBX20_22080862_ChIP-Seq_HEART_Mouse0.98136849
85TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.97892246
86RACK7_27058665_Chip-Seq_MCF-7_Human0.96870319
87NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.96310042
88ESR2_21235772_ChIP-Seq_MCF-7_Human0.95889674
89CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.92504361
90IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.91187277
91GATA4_25053715_ChIP-Seq_YYC3_Human0.90865398
92PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.90454705
93SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.89076732
94POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.86773670
95ATF3_27146783_Chip-Seq_COLON_Human0.85849019
96ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.82524537
97ELK3_25401928_ChIP-Seq_HUVEC_Human0.81685049
98KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.81240993
99* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.78134721
100RARA_24833708_ChIP-Seq_LIVER_Mouse0.76490448
101BCOR_27268052_Chip-Seq_Bcells_Human0.76332258
102RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.74759682
103GATA6_25053715_ChIP-Seq_YYC3_Human0.74366129
104PPAR_26484153_Chip-Seq_NCI-H1993_Human0.72601728
105BCL6_27268052_Chip-Seq_Bcells_Human0.71691193
106BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.70163893
107BRD4_27068464_Chip-Seq_AML-cells_Mouse0.69808901
108IRF8_22096565_ChIP-ChIP_GC-B_Human0.69461780
109P68_20966046_ChIP-Seq_HELA_Human0.69103824
110RARB_24833708_ChIP-Seq_LIVER_Mouse0.69011774
111ESR1_21235772_ChIP-Seq_MCF-7_Human0.68879855
112PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.68639551
113SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.67925087
114TP63_17297297_ChIP-ChIP_HaCaT_Human0.67383365
115* TET1_21451524_ChIP-Seq_MESCs_Mouse0.66221639
116GATA1_19941826_ChIP-Seq_K562_Human0.64958662
117OCT4_18692474_ChIP-Seq_MEFs_Mouse0.64869363
118SALL4_18804426_ChIP-ChIP_XEN_Mouse0.64796785
119FOXO3_23340844_ChIP-Seq_DLD1_Human0.64479984
120CDX2_20551321_ChIP-Seq_CACO-2_Human0.64162518
121CTCF_21964334_Chip-Seq_Bcells_Human0.64087529
122ESR1_20079471_ChIP-ChIP_T-47D_Human0.63576349
123GATA1_22383799_ChIP-Seq_G1ME_Mouse0.63535530
124GATA1_19941827_ChIP-Seq_MEL_Mouse0.63091839
125HTT_18923047_ChIP-ChIP_STHdh_Human0.62957689
126CEBPB_22108803_ChIP-Seq_LS180_Human0.61951502
127TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.61717581
128AR_21909140_ChIP-Seq_LNCAP_Human0.61526498
129GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.61125547
130AUTS2_25519132_ChIP-Seq_293T-REX_Human0.60850320
131SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.60695845
132CTCF_21964334_ChIP-Seq_BJAB-B_Human0.60539991
133BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.60124959
134VDR_21846776_ChIP-Seq_THP-1_Human0.60061442
135ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.59878904
136CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.58429997
137PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.58368190
138HIF1A_21447827_ChIP-Seq_MCF-7_Human0.58163435
139SOX2_18692474_ChIP-Seq_MEFs_Mouse0.58069500
140* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.57285227
141NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.56961760
142SPI1_20517297_ChIP-Seq_HL60_Human0.56073141
143GATA2_19941826_ChIP-Seq_K562_Human0.54680996
144RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.54598485
145CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.54285481
146FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.54128462
147* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.53930281

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.72470878
2MP0005360_urolithiasis6.42252620
3MP0005085_abnormal_gallbladder_physiolo5.22167854
4MP0005365_abnormal_bile_salt5.09459544
5MP0008875_abnormal_xenobiotic_pharmacok4.05283888
6MP0003806_abnormal_nucleotide_metabolis3.91438525
7MP0003252_abnormal_bile_duct3.30455867
8MP0010329_abnormal_lipoprotein_level3.21098787
9MP0009840_abnormal_foam_cell3.12678795
10MP0005332_abnormal_amino_acid2.80631607
11MP0003191_abnormal_cellular_cholesterol2.47631488
12MP0002837_dystrophic_cardiac_calcinosis2.47332467
13MP0005083_abnormal_biliary_tract2.42808860
14MP0005670_abnormal_white_adipose2.30258286
15MP0003195_calcinosis2.29571759
16MP0001666_abnormal_nutrient_absorption2.18415839
17MP0002118_abnormal_lipid_homeostasis2.07410866
18* MP0000609_abnormal_liver_physiology2.05831444
19MP0004130_abnormal_muscle_cell1.99846581
20MP0005319_abnormal_enzyme/_coenzyme1.96210701
21MP0004019_abnormal_vitamin_homeostasis1.91225055
22MP0003705_abnormal_hypodermis_morpholog1.88243364
23MP0004145_abnormal_muscle_electrophysio1.79646454
24MP0005666_abnormal_adipose_tissue1.76835419
25MP0003646_muscle_fatigue1.73120586
26MP0010155_abnormal_intestine_physiology1.72184204
27MP0004147_increased_porphyrin_level1.67134300
28MP0006036_abnormal_mitochondrial_physio1.65867026
29MP0002138_abnormal_hepatobiliary_system1.60786568
30MP0005584_abnormal_enzyme/coenzyme_acti1.59510326
31MP0003303_peritoneal_inflammation1.56841302
32* MP0009643_abnormal_urine_homeostasis1.54318928
33MP0003183_abnormal_peptide_metabolism1.53258383
34MP0003436_decreased_susceptibility_to1.48844333
35MP0001764_abnormal_homeostasis1.46134434
36MP0003186_abnormal_redox_activity1.44174038
37MP0005330_cardiomyopathy1.42681960
38MP0005451_abnormal_body_composition1.40098552
39MP0003724_increased_susceptibility_to1.32956996
40MP0004084_abnormal_cardiac_muscle1.30876670
41MP0009785_altered_susceptibility_to1.29547893
42MP0005166_decreased_susceptibility_to1.28665344
43MP0002876_abnormal_thyroid_physiology1.27762672
44MP0002971_abnormal_brown_adipose1.27543949
45MP0005025_abnormal_response_to1.23981931
46MP0004185_abnormal_adipocyte_glucose1.23200862
47MP0003868_abnormal_feces_composition1.19539025
48MP0002822_catalepsy1.19369104
49MP0000598_abnormal_liver_morphology1.17476445
50MP0000759_abnormal_skeletal_muscle1.13769998
51MP0000003_abnormal_adipose_tissue1.13123308
52MP0000013_abnormal_adipose_tissue1.12678072
53MP0008260_abnormal_autophagy1.09287636
54MP0003866_abnormal_defecation1.08682572
55MP0009379_abnormal_foot_pigmentation1.08075944
56MP0003879_abnormal_hair_cell1.06035162
57MP0000465_gastrointestinal_hemorrhage1.05652121
58MP0003075_altered_response_to1.04101545
59MP0005464_abnormal_platelet_physiology1.01884438
60MP0003656_abnormal_erythrocyte_physiolo1.01241399
61MP0004036_abnormal_muscle_relaxation1.01069402
62MP0002269_muscular_atrophy1.00831714
63MP0002148_abnormal_hypersensitivity_rea1.00615548
64MP0000751_myopathy0.98649053
65MP0005375_adipose_tissue_phenotype0.98440545
66MP0001835_abnormal_antigen_presentation0.97552310
67MP0001790_abnormal_immune_system0.96890904
68MP0005387_immune_system_phenotype0.96890904
69MP0001873_stomach_inflammation0.95636665
70MP0005165_increased_susceptibility_to0.95422590
71MP0002419_abnormal_innate_immunity0.94985946
72MP0004087_abnormal_muscle_fiber0.94538675
73MP0006035_abnormal_mitochondrial_morpho0.94519215
74MP0005636_abnormal_mineral_homeostasis0.94354859
75MP0005266_abnormal_metabolism0.93896635
76MP0005334_abnormal_fat_pad0.92456318
77MP0010368_abnormal_lymphatic_system0.92094408
78MP0004215_abnormal_myocardial_fiber0.91534093
79MP0009763_increased_sensitivity_to0.91421170
80MP0003221_abnormal_cardiomyocyte_apopto0.91378920
81MP0004510_myositis0.91328345
82* MP0002078_abnormal_glucose_homeostasis0.90517114
83MP0001845_abnormal_inflammatory_respons0.90437980
84MP0001756_abnormal_urination0.89407531
85MP0009333_abnormal_splenocyte_physiolog0.88475164
86MP0001663_abnormal_digestive_system0.88350218
87MP0004858_abnormal_nervous_system0.88235480
88MP0005385_cardiovascular_system_phenoty0.87767373
89MP0001544_abnormal_cardiovascular_syste0.87767373
90MP0010630_abnormal_cardiac_muscle0.87578820
91MP0002132_abnormal_respiratory_system0.87352648
92MP0005369_muscle_phenotype0.87104033
93MP0003828_pulmonary_edema0.85103169
94MP0001664_abnormal_digestion0.84902563
95MP0001533_abnormal_skeleton_physiology0.84812657
96MP0008775_abnormal_heart_ventricle0.84496865
97MP0005000_abnormal_immune_tolerance0.84192298
98MP0008469_abnormal_protein_level0.82979151
99* MP0009642_abnormal_blood_homeostasis0.82625875
100MP0000678_abnormal_parathyroid_gland0.82069561
101MP0005535_abnormal_body_temperature0.81719657
102MP0000685_abnormal_immune_system0.81624562
103MP0006138_congestive_heart_failure0.81307812
104MP0003011_delayed_dark_adaptation0.81093035
105MP0001545_abnormal_hematopoietic_system0.80629278
106MP0005397_hematopoietic_system_phenotyp0.80629278
107MP0005376_homeostasis/metabolism_phenot0.80248697
108MP0000749_muscle_degeneration0.80020632
109MP0001661_extended_life_span0.78743722
110MP0005647_abnormal_sex_gland0.78661753
111MP0009115_abnormal_fat_cell0.77480400
112MP0002970_abnormal_white_adipose0.73647820
113MP0009764_decreased_sensitivity_to0.73439304
114MP0004043_abnormal_pH_regulation0.72394930
115MP0002972_abnormal_cardiac_muscle0.72137475
116MP0000750_abnormal_muscle_regeneration0.70962492
117MP0002136_abnormal_kidney_physiology0.69361984
118MP0009697_abnormal_copulation0.67560517
119MP0000604_amyloidosis0.67275241
120MP0000747_muscle_weakness0.62728006
121MP0005058_abnormal_lysosome_morphology0.62057147
122MP0005620_abnormal_muscle_contractility0.61811803
123MP0005448_abnormal_energy_balance0.61774917
124MP0002254_reproductive_system_inflammat0.60749278
125MP0003300_gastrointestinal_ulcer0.56760175
126MP0000230_abnormal_systemic_arterial0.56126075
127MP0002332_abnormal_exercise_endurance0.55268320
128MP0000343_altered_response_to0.52147898
129MP0003566_abnormal_cell_adhesion0.49173085
130MP0005084_abnormal_gallbladder_morpholo0.48848422
131MP0008438_abnormal_cutaneous_collagen0.48666170
132MP0001853_heart_inflammation0.48358642
133MP0002796_impaired_skin_barrier0.48105025
134MP0009765_abnormal_xenobiotic_induced0.47329500
135MP0005220_abnormal_exocrine_pancreas0.47310427
136MP0008961_abnormal_basal_metabolism0.46516449
137MP0003137_abnormal_impulse_conducting0.46214593
138MP0009672_abnormal_birth_weight0.44674486
139MP0001765_abnormal_ion_homeostasis0.44396221
140MP0000249_abnormal_blood_vessel0.43625253
141MP0003953_abnormal_hormone_level0.43047131
142MP0002106_abnormal_muscle_physiology0.42538434
143MP0008873_increased_physiological_sensi0.41051060
144MP0005167_abnormal_blood-brain_barrier0.40734536

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)5.49290683
2Deep venous thrombosis (HP:0002625)5.42849388
3Intrahepatic cholestasis (HP:0001406)5.38815689
4Xanthomatosis (HP:0000991)5.19134342
5Hyperglycinuria (HP:0003108)5.12622204
6Abnormality of monocarboxylic acid metabolism (HP:0010996)4.93784254
7Hyperammonemia (HP:0001987)4.93568490
8Muscle fiber inclusion bodies (HP:0100299)4.80141581
9Hypoglycemic coma (HP:0001325)4.71718589
10Nemaline bodies (HP:0003798)4.70482986
11Ketosis (HP:0001946)4.69467947
12Abnormality of glycine metabolism (HP:0010895)4.66414925
13Abnormality of serine family amino acid metabolism (HP:0010894)4.66414925
14Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.65221072
15Hypobetalipoproteinemia (HP:0003563)4.55497250
16Abnormality of fatty-acid metabolism (HP:0004359)4.54618428
17Hyperlipoproteinemia (HP:0010980)4.36350145
18Hyperglycinemia (HP:0002154)4.32604014
19Prolonged partial thromboplastin time (HP:0003645)4.21644765
20Ketoacidosis (HP:0001993)4.01085428
21Complement deficiency (HP:0004431)3.98469936
22Abnormality of glutamine family amino acid metabolism (HP:0010902)3.95575137
23Hypolipoproteinemia (HP:0010981)3.91353392
24Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.87403744
25Myopathic facies (HP:0002058)3.84892372
26Hypoalphalipoproteinemia (HP:0003233)3.84294577
27Type 1 muscle fiber predominance (HP:0003803)3.79846816
28* Dicarboxylic aciduria (HP:0003215)3.65996558
29* Abnormality of dicarboxylic acid metabolism (HP:0010995)3.65996558
30Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.61247237
31Abnormality of aspartate family amino acid metabolism (HP:0010899)3.51697180
32Epidermoid cyst (HP:0200040)3.48451207
33Abnormality of sulfur amino acid metabolism (HP:0004339)3.47909936
34Myoglobinuria (HP:0002913)3.44763594
35Centrally nucleated skeletal muscle fibers (HP:0003687)3.44597959
36Joint hemorrhage (HP:0005261)3.25149360
37Abnormality of methionine metabolism (HP:0010901)3.15963584
38Generalized aminoaciduria (HP:0002909)3.14050305
39Abnormality of the common coagulation pathway (HP:0010990)3.10778610
40Abnormality of serum amino acid levels (HP:0003112)3.06847812
41Gout (HP:0001997)3.04447223
42Rhabdomyolysis (HP:0003201)2.99956507
43Abnormality of complement system (HP:0005339)2.92266545
44Abnormality of skeletal muscle fiber size (HP:0012084)2.91858718
45* Metabolic acidosis (HP:0001942)2.90522292
46Abnormality of purine metabolism (HP:0004352)2.88701634
47Fat malabsorption (HP:0002630)2.87593741
48* Lethargy (HP:0001254)2.87258635
49Cerebral edema (HP:0002181)2.85612875
50Abnormality of nucleobase metabolism (HP:0010932)2.84746058
51Distal lower limb muscle weakness (HP:0009053)2.84212936
52Hypercholesterolemia (HP:0003124)2.82387974
53Neck muscle weakness (HP:0000467)2.81501056
54EMG: myopathic abnormalities (HP:0003458)2.80233774
55Cerebral palsy (HP:0100021)2.80028414
56Muscle stiffness (HP:0003552)2.78634803
57Abnormality of pyrimidine metabolism (HP:0004353)2.76834905
58Abnormality of the intrinsic pathway (HP:0010989)2.75781854
59Hyperbilirubinemia (HP:0002904)2.70255093
60Delayed CNS myelination (HP:0002188)2.69462352
61Proximal tubulopathy (HP:0000114)2.69441124
62Muscle fiber splitting (HP:0003555)2.68740668
63Glomerulonephritis (HP:0000099)2.64675333
64Skin nodule (HP:0200036)2.58287233
65Nausea (HP:0002018)2.54458455
66Increased variability in muscle fiber diameter (HP:0003557)2.53189406
67Myocardial infarction (HP:0001658)2.49617627
68Bulbar palsy (HP:0001283)2.49079448
69Vomiting (HP:0002013)2.48882682
70Abnormality of proline metabolism (HP:0010907)2.46454336
71Hydroxyprolinuria (HP:0003080)2.46454336
72Hyporeflexia of lower limbs (HP:0002600)2.45648276
73Hepatic necrosis (HP:0002605)2.45583876
74Abnormal cartilage morphology (HP:0002763)2.42914478
75Hepatocellular carcinoma (HP:0001402)2.37001085
76Ileus (HP:0002595)2.36203133
77Eczematoid dermatitis (HP:0000976)2.36105878
78Increased purine levels (HP:0004368)2.34016378
79Hyperuricemia (HP:0002149)2.34016378
80Late onset (HP:0003584)2.33139980
81Cholelithiasis (HP:0001081)2.29148765
82Increased muscle lipid content (HP:0009058)2.28120798
83Distal arthrogryposis (HP:0005684)2.26220727
84Distal lower limb amyotrophy (HP:0008944)2.25424659
85Spastic diplegia (HP:0001264)2.24601264
86Right ventricular cardiomyopathy (HP:0011663)2.24567868
87Muscle hypertrophy of the lower extremities (HP:0008968)2.24471676
88Difficulty running (HP:0009046)2.22777463
89Hypoglycemic seizures (HP:0002173)2.22685157
90Abnormal gallbladder morphology (HP:0012437)2.19316423
91Hyperinsulinemic hypoglycemia (HP:0000825)2.17555500
92Ventricular tachycardia (HP:0004756)2.15310172
93Pancreatitis (HP:0001733)2.13961287
94Conjugated hyperbilirubinemia (HP:0002908)2.13678185
95Recurrent gram-negative bacterial infections (HP:0005420)2.12852441
96Vascular calcification (HP:0004934)2.10715616
97Exercise-induced myalgia (HP:0003738)2.10713561
98Palpitations (HP:0001962)2.09963281
99Rimmed vacuoles (HP:0003805)2.09845831
100Ragged-red muscle fibers (HP:0003200)2.09303858
101Sudden death (HP:0001699)2.08503834
102Malnutrition (HP:0004395)2.07564291
103Hypertriglyceridemia (HP:0002155)2.07317621
104Steatorrhea (HP:0002570)2.06567985
105Renal cortical cysts (HP:0000803)2.05439434
106Systemic lupus erythematosus (HP:0002725)2.05384385
107Mildly elevated creatine phosphokinase (HP:0008180)2.05032983
108Esophageal varix (HP:0002040)2.03895618
109Round ear (HP:0100830)2.03430532
110Colitis (HP:0002583)2.01382023
111Glycosuria (HP:0003076)2.01273333
112Abnormality of urine glucose concentration (HP:0011016)2.01273333
113Increased intramyocellular lipid droplets (HP:0012240)2.00642102
114Sensorimotor neuropathy (HP:0007141)1.99650980
115Irritability (HP:0000737)1.99324267
116Dilated cardiomyopathy (HP:0001644)1.99310910
117Exercise-induced muscle cramps (HP:0003710)1.97785160
118Ulnar deviation of the wrist (HP:0003049)1.97449123
119Abnormality of liposaccharide metabolism (HP:0010968)1.96703154
120Abnormality of glycosphingolipid metabolism (HP:0004343)1.96703154
121Abnormality of glycolipid metabolism (HP:0010969)1.96703154
122Multiple enchondromatosis (HP:0005701)1.92675279
123Nephritis (HP:0000123)1.92399359
124Cardiovascular calcification (HP:0011915)1.91946212
125Growth hormone excess (HP:0000845)1.90317810
126Hyperglycemia (HP:0003074)1.88503393
127Calf muscle hypertrophy (HP:0008981)1.88155195
128Bundle branch block (HP:0011710)1.86470415
129Atrioventricular block (HP:0001678)1.85732406
130Abnormal gallbladder physiology (HP:0012438)1.84104092
131Cholecystitis (HP:0001082)1.84104092
132Asymmetric septal hypertrophy (HP:0001670)1.83479715
133Axonal loss (HP:0003447)1.83443714
134Spontaneous abortion (HP:0005268)1.82892729
135Brushfield spots (HP:0001088)1.82493106
136Methylmalonic aciduria (HP:0012120)1.82355269
137Abnormality of the calf musculature (HP:0001430)1.80863363
138Polycythemia (HP:0001901)1.80542335
139Hemorrhage of the eye (HP:0011885)1.80381037
140Increased connective tissue (HP:0009025)1.79455988
141Vertebral compression fractures (HP:0002953)1.78268583
142Purpura (HP:0000979)1.78104753
143Alkalosis (HP:0001948)1.77960260
144Amyloidosis (HP:0011034)1.77301065
145Chronic diarrhea (HP:0002028)1.74456456
146Increased serum ferritin (HP:0003281)1.73703535
147Dysostosis multiplex (HP:0000943)1.72688462
148Lipoatrophy (HP:0100578)1.70187055
149Generalized muscle weakness (HP:0003324)1.69532812
150Progressive muscle weakness (HP:0003323)1.68183849
151Abnormal pupillary function (HP:0007686)1.67473753

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.53907924
2TRIB34.23192448
3PKN23.87765743
4ERN13.45931107
5SIK13.13657403
6FGFR42.80597648
7TTN2.63302193
8PDK42.57442533
9PDK32.57442533
10TESK22.27820718
11FLT32.26090840
12PRPF4B2.08622147
13TESK11.96576910
14NEK11.78443628
15MST1R1.71584250
16MAP2K31.56583912
17LMTK21.52424499
18ACVR1B1.52308204
19PDK21.49013349
20MAP3K101.43374756
21MAP3K71.42705000
22MAPK111.41578349
23INSRR1.40733914
24MYLK1.40727432
25PTK61.38721273
26STK38L1.35208550
27CAMK1D1.34867526
28PIM21.33634421
29TIE11.32721656
30PINK11.31089060
31MAP3K11.29874117
32KDR1.28716219
33ARAF1.26058382
34PIK3CA1.24389310
35TAOK21.23637807
36OBSCN1.19120067
37PRKAA21.19003341
38TYK21.18087792
39SMG11.16489395
40TGFBR21.14629561
41RIPK11.13447563
42SCYL21.11018994
43NEK91.08167514
44RIPK41.02834352
45MAP3K30.98216153
46PHKG10.96168871
47PHKG20.96168871
48ERBB40.95327015
49EEF2K0.94984622
50TBK10.93838307
51PIK3CG0.93396425
52LATS10.90885715
53MAP3K110.88795765
54IKBKE0.88757883
55PRKAA10.86041664
56MAP3K130.85366888
57GRK60.85200977
58TAOK30.82961397
59MAPKAPK30.81664145
60PDGFRA0.81626618
61LRRK20.80989070
62CDC42BPA0.80607888
63CDK40.79990384
64EPHB10.79919159
65TAOK10.78284746
66JAK20.78233167
67ABL20.78193555
68WNK40.77169664
69MAP3K140.76727595
70BLK0.75858397
71KSR20.75845224
72JAK30.75175659
73ICK0.74885648
74DDR20.74548244
75MATK0.74068168
76MAPK120.71778099
77MAP2K40.68547036
78NME20.68386371
79TXK0.68025921
80PDPK10.67871682
81CDK60.67115666
82MAP2K20.66300742
83MUSK0.66133310
84MET0.65332852
85MTOR0.65263404
86DMPK0.65101330
87SYK0.62601617
88TNK20.61615686
89IRAK40.61059844
90EPHA30.60771954
91MAP4K10.59789627
92JAK10.59088510
93FES0.58251052
94MAPK70.58119842
95MAPK40.56449891
96RPS6KC10.56172538
97RPS6KL10.56172538
98PRKACG0.56004904
99CAMK2G0.55891965
100ILK0.54247649
101CSF1R0.52983393
102PDK10.52426976
103MAP3K60.51841807
104PRKD10.51208801
105MAP2K10.50904885
106CSK0.50785907
107DYRK1B0.50674607
108MAP3K50.49007347
109BTK0.46001709
110GSK3A0.45897295
111CAMK1G0.45762654
112MAP2K60.45426547
113IKBKB0.44785452
114LIMK10.44335686
115RPS6KA60.42237268
116STK40.41825028
117PAK40.41761536
118RPS6KA20.40071822
119AKT20.39052037
120TGFBR10.38169453
121DAPK30.36855126
122EPHA20.36487394
123MAP3K80.35580078
124STK100.35220892
125IRAK30.35139125
126ZAP700.34053919
127PTK20.33964416
128PRKG20.33902633
129FGFR30.32944581
130PAK30.32601142
131ERBB20.30417175
132EPHB20.30317478
133FRK0.30104403
134RPS6KB20.29443229
135FGFR20.28206375
136CAMK40.28022841
137KIT0.27538299
138BMX0.26191365

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.52246542
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.26392679
3* Fatty acid degradation_Homo sapiens_hsa000713.11664657
4Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.99437133
5* Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.98277834
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.93824407
7Propanoate metabolism_Homo sapiens_hsa006402.93598587
8Nitrogen metabolism_Homo sapiens_hsa009102.82881765
92-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.81014008
10Arginine biosynthesis_Homo sapiens_hsa002202.61829929
11Tryptophan metabolism_Homo sapiens_hsa003802.59180074
12Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.45742862
13* Fatty acid metabolism_Homo sapiens_hsa012122.32232787
14Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.31488629
15Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.23702957
16PPAR signaling pathway_Homo sapiens_hsa033202.21390664
17* Butanoate metabolism_Homo sapiens_hsa006502.16258560
18Pentose and glucuronate interconversions_Homo sapiens_hsa000402.08603143
19Peroxisome_Homo sapiens_hsa041462.07744028
20Complement and coagulation cascades_Homo sapiens_hsa046101.99429444
21Pyruvate metabolism_Homo sapiens_hsa006201.97543740
22* Carbon metabolism_Homo sapiens_hsa012001.89533359
23beta-Alanine metabolism_Homo sapiens_hsa004101.84675931
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.72126255
25Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.63805438
26Other glycan degradation_Homo sapiens_hsa005111.60923253
27Biosynthesis of amino acids_Homo sapiens_hsa012301.52830943
28Chemical carcinogenesis_Homo sapiens_hsa052041.49568151
29Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.49071995
30Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.48860229
31Drug metabolism - other enzymes_Homo sapiens_hsa009831.48409321
32Caffeine metabolism_Homo sapiens_hsa002321.48309719
33Fatty acid elongation_Homo sapiens_hsa000621.46975135
34Histidine metabolism_Homo sapiens_hsa003401.43837340
35Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.42724627
36Selenocompound metabolism_Homo sapiens_hsa004501.41288533
37Phenylalanine metabolism_Homo sapiens_hsa003601.39502123
38Starch and sucrose metabolism_Homo sapiens_hsa005001.36683360
39Sulfur metabolism_Homo sapiens_hsa009201.36278572
40Steroid hormone biosynthesis_Homo sapiens_hsa001401.36216080
41Cysteine and methionine metabolism_Homo sapiens_hsa002701.28241981
42Bile secretion_Homo sapiens_hsa049761.26861863
43Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.26068267
44Retinol metabolism_Homo sapiens_hsa008301.25645678
45Staphylococcus aureus infection_Homo sapiens_hsa051501.25106649
46Tyrosine metabolism_Homo sapiens_hsa003501.23066061
47Fat digestion and absorption_Homo sapiens_hsa049751.22966490
48Sulfur relay system_Homo sapiens_hsa041221.15586110
49Folate biosynthesis_Homo sapiens_hsa007901.12368658
50Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.08177765
51Cyanoamino acid metabolism_Homo sapiens_hsa004601.04497309
52Mineral absorption_Homo sapiens_hsa049781.03162560
53Lysine degradation_Homo sapiens_hsa003101.02921123
54Arginine and proline metabolism_Homo sapiens_hsa003301.01677301
55Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.95049300
56ABC transporters_Homo sapiens_hsa020100.95005985
57Glycerolipid metabolism_Homo sapiens_hsa005610.90541468
58Pentose phosphate pathway_Homo sapiens_hsa000300.88853404
59Fatty acid biosynthesis_Homo sapiens_hsa000610.87704045
60Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.85349879
61Asthma_Homo sapiens_hsa053100.84205176
62Intestinal immune network for IgA production_Homo sapiens_hsa046720.82415146
63Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.80112369
64Vitamin B6 metabolism_Homo sapiens_hsa007500.76356638
65Allograft rejection_Homo sapiens_hsa053300.74654406
66Vitamin digestion and absorption_Homo sapiens_hsa049770.72562111
67Glutathione metabolism_Homo sapiens_hsa004800.72555369
68Autoimmune thyroid disease_Homo sapiens_hsa053200.70003235
69One carbon pool by folate_Homo sapiens_hsa006700.66361604
70Carbohydrate digestion and absorption_Homo sapiens_hsa049730.62868028
71Fructose and mannose metabolism_Homo sapiens_hsa000510.61517076
72Pertussis_Homo sapiens_hsa051330.60872130
73Graft-versus-host disease_Homo sapiens_hsa053320.58202987
74Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.57787930
75Maturity onset diabetes of the young_Homo sapiens_hsa049500.57103212
76Galactose metabolism_Homo sapiens_hsa000520.55794252
77Leishmaniasis_Homo sapiens_hsa051400.55479210
78Adipocytokine signaling pathway_Homo sapiens_hsa049200.54628444
79Steroid biosynthesis_Homo sapiens_hsa001000.52573474
80* Metabolic pathways_Homo sapiens_hsa011000.51887551
81Insulin resistance_Homo sapiens_hsa049310.51025591
82Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.47333169
83Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.46139161
84Viral myocarditis_Homo sapiens_hsa054160.44008841
85Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.42317663
86Antigen processing and presentation_Homo sapiens_hsa046120.37517890
87Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.37130317
88Primary immunodeficiency_Homo sapiens_hsa053400.36846101
89Lysosome_Homo sapiens_hsa041420.36067147
90AMPK signaling pathway_Homo sapiens_hsa041520.34643468
91Glucagon signaling pathway_Homo sapiens_hsa049220.29021929
92alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.22476233
93Type I diabetes mellitus_Homo sapiens_hsa049400.21004268
94Tuberculosis_Homo sapiens_hsa051520.20397150
95Osteoclast differentiation_Homo sapiens_hsa043800.19433997
96Parkinsons disease_Homo sapiens_hsa050120.19335392
97Acute myeloid leukemia_Homo sapiens_hsa052210.18758840
98Glycerophospholipid metabolism_Homo sapiens_hsa005640.17984888
99Insulin signaling pathway_Homo sapiens_hsa049100.17634121
100Oxidative phosphorylation_Homo sapiens_hsa001900.16069948
101Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.11797700
102Prion diseases_Homo sapiens_hsa050200.11535373
103Linoleic acid metabolism_Homo sapiens_hsa005910.10515716
104Central carbon metabolism in cancer_Homo sapiens_hsa052300.09672157
105Cardiac muscle contraction_Homo sapiens_hsa042600.06375990
106Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1838779
107Amoebiasis_Homo sapiens_hsa05146-0.1708842
108Bladder cancer_Homo sapiens_hsa05219-0.1529378
109Protein digestion and absorption_Homo sapiens_hsa04974-0.1435197
110Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1317418
111Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923-0.1267576
112Huntingtons disease_Homo sapiens_hsa05016-0.1092008
113Dilated cardiomyopathy_Homo sapiens_hsa05414-0.0899007
114Terpenoid backbone biosynthesis_Homo sapiens_hsa00900-0.0726977
115Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.0685413
116Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.0675193
117Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410-0.0521050
118Renin-angiotensin system_Homo sapiens_hsa04614-0.0479588
119Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0218170
120Alzheimers disease_Homo sapiens_hsa05010-0.0024969

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