ACADSB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Short/branched chain acyl-CoA dehydrogenase(ACADSB) is a member of the acyl-CoA dehydrogenase family of enzymes that catalyze the dehydrogenation of acyl-CoA derivatives in the metabolism of fatty acids or branch chained amino acids. Substrate specificity is the primary characteristic used to define members of this gene family. The ACADSB gene product has the greatest activity towards the short branched chain acyl-CoA derivative, (S)-2-methylbutyryl-CoA, but also reacts significantly with other 2-methyl branched chain substrates and with short straight chain acyl-CoAs. The cDNA encodes for a mitochondrial precursor protein which is cleaved upon mitochondrial import and predicted to yield a mature peptide of approximately 43.7-KDa. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1exogenous drug catabolic process (GO:0042738)6.40357673
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.63244523
3L-phenylalanine catabolic process (GO:0006559)5.63244523
4omega-hydroxylase P450 pathway (GO:0097267)5.54317723
5blood coagulation, intrinsic pathway (GO:0007597)5.36316067
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.30163545
7L-phenylalanine metabolic process (GO:0006558)5.30163545
8aromatic amino acid family catabolic process (GO:0009074)5.09975365
9very-low-density lipoprotein particle assembly (GO:0034379)4.90832012
10intestinal cholesterol absorption (GO:0030299)4.79423456
11alpha-linolenic acid metabolic process (GO:0036109)4.75397500
12indole-containing compound catabolic process (GO:0042436)4.70168897
13indolalkylamine catabolic process (GO:0046218)4.70168897
14tryptophan catabolic process (GO:0006569)4.70168897
15negative regulation of sterol transport (GO:0032372)4.58618824
16negative regulation of cholesterol transport (GO:0032375)4.58618824
17kynurenine metabolic process (GO:0070189)4.51165512
18tryptophan metabolic process (GO:0006568)4.46432969
19ethanol metabolic process (GO:0006067)4.46342361
20lysine metabolic process (GO:0006553)4.45561093
21lysine catabolic process (GO:0006554)4.45561093
22fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.41488221
23oxidative demethylation (GO:0070989)4.40137763
24glyoxylate metabolic process (GO:0046487)4.39502204
25triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.39188039
26complement activation, alternative pathway (GO:0006957)4.37763531
27bile acid biosynthetic process (GO:0006699)4.37320991
28homocysteine metabolic process (GO:0050667)4.37001825
29low-density lipoprotein particle remodeling (GO:0034374)4.34857298
30valine metabolic process (GO:0006573)4.34832498
31plasma lipoprotein particle assembly (GO:0034377)4.33121065
32fibrinolysis (GO:0042730)4.26218534
33sulfur amino acid catabolic process (GO:0000098)4.24767424
34cysteine metabolic process (GO:0006534)4.20696970
35protein activation cascade (GO:0072376)4.19001450
36negative regulation of complement activation (GO:0045916)4.18675732
37drug metabolic process (GO:0017144)4.17232915
38regulation of plasminogen activation (GO:0010755)4.14787618
39urea metabolic process (GO:0019627)4.03314201
40urea cycle (GO:0000050)4.03314201
41positive regulation of heterotypic cell-cell adhesion (GO:0034116)4.02217782
42regulation of protein activation cascade (GO:2000257)4.00834942
43regulation of humoral immune response (GO:0002920)4.00278470
44cellular ketone body metabolic process (GO:0046950)4.00234178
45amino-acid betaine metabolic process (GO:0006577)3.98327107
46plasma lipoprotein particle organization (GO:0071827)3.97615729
47protein carboxylation (GO:0018214)3.97499592
48peptidyl-glutamic acid carboxylation (GO:0017187)3.97499592
49fatty acid beta-oxidation (GO:0006635)3.97127250
50regulation of triglyceride catabolic process (GO:0010896)3.96626258
51imidazole-containing compound metabolic process (GO:0052803)3.93560712
52short-chain fatty acid metabolic process (GO:0046459)3.88519897
532-oxoglutarate metabolic process (GO:0006103)3.85896574
54regulation of complement activation (GO:0030449)3.83312212
55complement activation, classical pathway (GO:0006958)3.82274515
56biotin metabolic process (GO:0006768)3.82245126
57protein-lipid complex assembly (GO:0065005)3.81197269
58fatty acid oxidation (GO:0019395)3.79726702
59regulation of sequestering of triglyceride (GO:0010889)3.79042079
60* branched-chain amino acid catabolic process (GO:0009083)3.76531771
61positive regulation of fatty acid beta-oxidation (GO:0032000)3.74926760
62alpha-amino acid catabolic process (GO:1901606)3.74323948
63lipid oxidation (GO:0034440)3.74143117
64bile acid metabolic process (GO:0008206)3.74065993
65high-density lipoprotein particle remodeling (GO:0034375)3.71455465
66protein-lipid complex subunit organization (GO:0071825)3.71445497
67nitrogen cycle metabolic process (GO:0071941)3.69434146
68coenzyme catabolic process (GO:0009109)3.69055405
69triglyceride homeostasis (GO:0070328)3.68541683
70acylglycerol homeostasis (GO:0055090)3.68541683
71fatty acid catabolic process (GO:0009062)3.68047861
72fatty acid transmembrane transport (GO:1902001)3.67779899
73aromatic amino acid family metabolic process (GO:0009072)3.63896498
74complement activation (GO:0006956)3.62984016
75acute-phase response (GO:0006953)3.62504025
76negative regulation of hemostasis (GO:1900047)3.62439801
77negative regulation of blood coagulation (GO:0030195)3.62439801
78acetyl-CoA metabolic process (GO:0006084)3.62434489
79serine family amino acid catabolic process (GO:0009071)3.61531277
80* branched-chain amino acid metabolic process (GO:0009081)3.61238447
81response to mercury ion (GO:0046689)3.60258254
82positive regulation of fatty acid oxidation (GO:0046321)3.58757089
83S-adenosylmethionine metabolic process (GO:0046500)3.57817987
84tyrosine metabolic process (GO:0006570)3.57332011
85* cellular amino acid catabolic process (GO:0009063)3.54422740
86monocarboxylic acid catabolic process (GO:0072329)3.53955623
87cellular modified amino acid catabolic process (GO:0042219)3.53067421
88negative regulation of fibrinolysis (GO:0051918)3.51683536
89regulation of fibrinolysis (GO:0051917)3.50106002
90regulation of apoptotic cell clearance (GO:2000425)3.48178310
91reverse cholesterol transport (GO:0043691)3.45898182
92plasma lipoprotein particle clearance (GO:0034381)3.45275337
93phenylpropanoid metabolic process (GO:0009698)3.44452150
94indolalkylamine metabolic process (GO:0006586)3.43912179
95ketone body metabolic process (GO:1902224)3.43901278
96amine catabolic process (GO:0009310)3.40418608
97cellular biogenic amine catabolic process (GO:0042402)3.40418608
98flavonoid metabolic process (GO:0009812)3.39876183
99phospholipid homeostasis (GO:0055091)3.39318833
100positive regulation of blood coagulation (GO:0030194)3.36858621
101positive regulation of hemostasis (GO:1900048)3.36858621
102dicarboxylic acid biosynthetic process (GO:0043650)3.36640138
103* organic acid catabolic process (GO:0016054)3.36516493
104* carboxylic acid catabolic process (GO:0046395)3.36516493
105glutamate metabolic process (GO:0006536)3.36385648
106glycine metabolic process (GO:0006544)3.36033729
107aspartate family amino acid catabolic process (GO:0009068)3.35450297
108carnitine shuttle (GO:0006853)3.33582298
109ethanol oxidation (GO:0006069)3.33074327
110carnitine metabolic process (GO:0009437)3.32597818
111protein-lipid complex remodeling (GO:0034368)3.31765966
112macromolecular complex remodeling (GO:0034367)3.31765966
113plasma lipoprotein particle remodeling (GO:0034369)3.31765966
114positive regulation of lipid catabolic process (GO:0050996)3.30479966
115negative regulation of coagulation (GO:0050819)3.26752539
116cellular glucuronidation (GO:0052695)3.24886417
117lipoprotein metabolic process (GO:0042157)3.23765225
118regulation of bile acid biosynthetic process (GO:0070857)3.21390360
119benzene-containing compound metabolic process (GO:0042537)3.18419988
120negative regulation of lipase activity (GO:0060192)3.16817397
121positive regulation of lipoprotein lipase activity (GO:0051006)3.16604475
122positive regulation of triglyceride lipase activity (GO:0061365)3.16604475
123negative regulation of humoral immune response (GO:0002921)3.16586996
124sodium-independent organic anion transport (GO:0043252)3.16517826
125negative regulation of wound healing (GO:0061045)3.15592967
126opsonization (GO:0008228)3.15142897
127linoleic acid metabolic process (GO:0043651)3.14662536
128embryonic retina morphogenesis in camera-type eye (GO:0060059)3.12047746
129drug transmembrane transport (GO:0006855)3.05933409
130regulation of cholesterol esterification (GO:0010872)3.03179752
131bile acid and bile salt transport (GO:0015721)3.01671541
132phospholipid efflux (GO:0033700)3.00728763
133cytolysis (GO:0019835)2.96817707
134regulation of fatty acid beta-oxidation (GO:0031998)2.96378635
135epoxygenase P450 pathway (GO:0019373)2.91005649
136regulation of fatty acid oxidation (GO:0046320)2.90534942
137glucuronate metabolic process (GO:0019585)2.90148156
138uronic acid metabolic process (GO:0006063)2.90148156
139drug catabolic process (GO:0042737)2.88164707
140cholesterol efflux (GO:0033344)2.86831007
141tricarboxylic acid metabolic process (GO:0072350)2.86175155
142acylglycerol catabolic process (GO:0046464)2.82502317
143neutral lipid catabolic process (GO:0046461)2.82502317
144succinate metabolic process (GO:0006105)2.82257737
145negative regulation of protein activation cascade (GO:2000258)2.79254345

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.80132454
2RXR_22158963_ChIP-Seq_LIVER_Mouse4.94254132
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.69087259
4LXR_22158963_ChIP-Seq_LIVER_Mouse4.16532987
5PPARA_22158963_ChIP-Seq_LIVER_Mouse4.10253170
6EGR1_23403033_ChIP-Seq_LIVER_Mouse3.98617385
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.43554463
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.01583023
9* CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.35717937
10IGF1R_20145208_ChIP-Seq_DFB_Human2.17982502
11TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.14375997
12FLI1_27457419_Chip-Seq_LIVER_Mouse1.96923681
13GBX2_23144817_ChIP-Seq_PC3_Human1.92752302
14PCGF2_27294783_Chip-Seq_ESCs_Mouse1.80345570
15CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.71104268
16FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.62436198
17GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.62404096
18GATA1_22025678_ChIP-Seq_K562_Human1.58429103
19VDR_22108803_ChIP-Seq_LS180_Human1.56860261
20ER_23166858_ChIP-Seq_MCF-7_Human1.54328143
21CDX2_19796622_ChIP-Seq_MESCs_Mouse1.50964036
22PIAS1_25552417_ChIP-Seq_VCAP_Human1.48914630
23CLOCK_20551151_ChIP-Seq_293T_Human1.48192526
24ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.47198581
25PCGF2_27294783_Chip-Seq_NPCs_Mouse1.46598007
26NRF2_20460467_ChIP-Seq_MEFs_Mouse1.46365834
27NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.46365834
28* FOXA2_19822575_ChIP-Seq_HepG2_Human1.40403488
29PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.39618706
30BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.38642125
31CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.38240200
32E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.38058950
33TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.37357351
34HTT_18923047_ChIP-ChIP_STHdh_Human1.32701008
35FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.31088809
36TCF4_18268006_ChIP-ChIP_LS174T_Human1.29591479
37PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.28534627
38TCF4_23295773_ChIP-Seq_U87_Human1.28310612
39ESR1_20079471_ChIP-ChIP_T-47D_Human1.26673138
40CRX_20693478_ChIP-Seq_RETINA_Mouse1.25099098
41ZNF217_24962896_ChIP-Seq_MCF-7_Human1.24834683
42ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.22434048
43EP300_21415370_ChIP-Seq_HL-1_Mouse1.21822691
44TAF15_26573619_Chip-Seq_HEK293_Human1.21783151
45AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.21047568
46SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.20872030
47CDX2_22108803_ChIP-Seq_LS180_Human1.20451661
48TP53_16413492_ChIP-PET_HCT116_Human1.16070953
49TRIM28_21343339_ChIP-Seq_HEK293_Human1.14644824
50BCAT_22108803_ChIP-Seq_LS180_Human1.13457748
51* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.13168173
52TCF4_22108803_ChIP-Seq_LS180_Human1.13150973
53OCT4_21477851_ChIP-Seq_ESCs_Mouse1.12505075
54SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.12429659
55CTNNB1_20460455_ChIP-Seq_HCT116_Human1.11443943
56ZNF274_21170338_ChIP-Seq_K562_Hela1.11144001
57ESR1_21235772_ChIP-Seq_MCF-7_Human1.10145635
58KLF5_20875108_ChIP-Seq_MESCs_Mouse1.08273487
59SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.06883718
60EED_16625203_ChIP-ChIP_MESCs_Mouse1.06759188
61CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.06293270
62FOXA1_25552417_ChIP-Seq_VCAP_Human1.05518598
63FOXO3_23340844_ChIP-Seq_DLD1_Human1.05324627
64EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.05080670
65POU3F2_20337985_ChIP-ChIP_501MEL_Human1.04741691
66OCT4_18555785_Chip-Seq_ESCs_Mouse1.04716508
67* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.02244593
68SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.02231566
69NANOG_18555785_Chip-Seq_ESCs_Mouse1.02098389
70E2F1_18555785_Chip-Seq_ESCs_Mouse1.01693889
71TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.00778178
72SMAD4_21741376_ChIP-Seq_EPCs_Human1.00299893
73RARG_19884340_ChIP-ChIP_MEFs_Mouse0.99955117
74Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.98677678
75PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.98642369
76SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.98633710
77SMAD3_21741376_ChIP-Seq_EPCs_Human0.98190661
78P53_22387025_ChIP-Seq_ESCs_Mouse0.97800910
79AR_21572438_ChIP-Seq_LNCaP_Human0.97787253
80SUZ12_18555785_Chip-Seq_ESCs_Mouse0.97764731
81STAT3_18555785_Chip-Seq_ESCs_Mouse0.97680340
82ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.97612408
83P300_19829295_ChIP-Seq_ESCs_Human0.97201979
84P300_18555785_Chip-Seq_ESCs_Mouse0.97074170
85SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.96898954
86ESR2_21235772_ChIP-Seq_MCF-7_Human0.96656173
87SMAD1_18555785_Chip-Seq_ESCs_Mouse0.96650269
88SALL4_18804426_ChIP-ChIP_XEN_Mouse0.96617104
89SMAD3_21741376_ChIP-Seq_HESCs_Human0.96590056
90ZFP57_27257070_Chip-Seq_ESCs_Mouse0.96341428
91EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.95975686
92* HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.94895229
93SMAD4_21799915_ChIP-Seq_A2780_Human0.94528084
94* HNF4A_19822575_ChIP-Seq_HepG2_Human0.93719441
95DROSHA_22980978_ChIP-Seq_HELA_Human0.92257339
96MTF2_20144788_ChIP-Seq_MESCs_Mouse0.91647041
97* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.91306699
98NR3C1_21868756_ChIP-Seq_MCF10A_Human0.90432875
99PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.89965041
100AHR_22903824_ChIP-Seq_MCF-7_Human0.89913893
101CJUN_26792858_Chip-Seq_BT549_Human0.89547442
102EZH2_18974828_ChIP-Seq_MESCs_Mouse0.89172959
103RNF2_18974828_ChIP-Seq_MESCs_Mouse0.89172959
104ARNT_22903824_ChIP-Seq_MCF-7_Human0.88756797
105CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.87850705
106SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.87471600
107SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.86747821
108AR_25329375_ChIP-Seq_VCAP_Human0.86542979
109SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.86441672
110CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.84827875
111EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.84663322
112SUZ12_27294783_Chip-Seq_NPCs_Mouse0.84291716
113GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84218642
114CTBP2_25329375_ChIP-Seq_LNCAP_Human0.83938593
115SOX2_21211035_ChIP-Seq_LN229_Gbm0.81728554
116TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.81458632
117NR3C1_23031785_ChIP-Seq_PC12_Mouse0.80224394
118TP53_18474530_ChIP-ChIP_U2OS_Human0.79968849
119TBX20_22328084_ChIP-Seq_HEART_Mouse0.79858350
120TBX20_22080862_ChIP-Seq_HEART_Mouse0.79858350
121UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.79712347
122CTBP1_25329375_ChIP-Seq_LNCAP_Human0.79137061
123EZH2_27294783_Chip-Seq_NPCs_Mouse0.78722986
124STAT3_23295773_ChIP-Seq_U87_Human0.77970029
125PPAR_26484153_Chip-Seq_NCI-H1993_Human0.77572476
126SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.77534538
127CBP_20019798_ChIP-Seq_JUKART_Human0.77020237
128IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.77020237
129SMAD4_21741376_ChIP-Seq_HESCs_Human0.76273642
130FOXM1_26456572_ChIP-Seq_MCF-7_Human0.76044932
131GATA2_21666600_ChIP-Seq_HMVEC_Human0.75584880
132RXR_22108803_ChIP-Seq_LS180_Human0.75456746
133JARID2_20075857_ChIP-Seq_MESCs_Mouse0.75329169
134TOP2B_26459242_ChIP-Seq_MCF-7_Human0.74309671
135* SOX2_20726797_ChIP-Seq_SW620_Human0.73644909
136CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.73625548
137MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.72487714
138ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.72404226
139GATA4_25053715_ChIP-Seq_YYC3_Human0.72397050
140NFE2_27457419_Chip-Seq_LIVER_Mouse0.72029457

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.55313265
2MP0005360_urolithiasis5.91604492
3MP0005365_abnormal_bile_salt5.42143658
4MP0005085_abnormal_gallbladder_physiolo5.11601998
5MP0008875_abnormal_xenobiotic_pharmacok3.89385674
6MP0003252_abnormal_bile_duct3.43050229
7MP0010329_abnormal_lipoprotein_level3.22677009
8MP0003195_calcinosis2.95100559
9MP0005083_abnormal_biliary_tract2.67448034
10MP0005670_abnormal_white_adipose2.64087516
11MP0005332_abnormal_amino_acid2.59536361
12MP0004130_abnormal_muscle_cell2.51361414
13MP0002837_dystrophic_cardiac_calcinosis2.49793287
14MP0001666_abnormal_nutrient_absorption2.48553805
15MP0003806_abnormal_nucleotide_metabolis2.39907926
16MP0002118_abnormal_lipid_homeostasis2.13786383
17MP0004019_abnormal_vitamin_homeostasis2.00988985
18MP0002138_abnormal_hepatobiliary_system1.75213751
19MP0003868_abnormal_feces_composition1.75133942
20MP0000609_abnormal_liver_physiology1.68900974
21MP0005666_abnormal_adipose_tissue1.66741843
22MP0002876_abnormal_thyroid_physiology1.65561995
23MP0003191_abnormal_cellular_cholesterol1.64748503
24MP0008438_abnormal_cutaneous_collagen1.64454021
25MP0004145_abnormal_muscle_electrophysio1.60747562
26MP0005408_hypopigmentation1.58311619
27MP0003122_maternal_imprinting1.55288539
28MP0005319_abnormal_enzyme/_coenzyme1.54593292
29MP0005584_abnormal_enzyme/coenzyme_acti1.44748270
30MP0009840_abnormal_foam_cell1.43219989
31MP0009780_abnormal_chondrocyte_physiolo1.36168612
32MP0001764_abnormal_homeostasis1.34966880
33MP0002971_abnormal_brown_adipose1.34294327
34MP0009643_abnormal_urine_homeostasis1.32667567
35MP0003879_abnormal_hair_cell1.29073054
36MP0004043_abnormal_pH_regulation1.27182197
37MP0005535_abnormal_body_temperature1.26609662
38MP0005334_abnormal_fat_pad1.25921631
39MP0002078_abnormal_glucose_homeostasis1.23343666
40MP0005647_abnormal_sex_gland1.19146770
41MP0005375_adipose_tissue_phenotype1.17051322
42MP0009697_abnormal_copulation1.15315726
43MP0004185_abnormal_adipocyte_glucose1.14477913
44MP0005220_abnormal_exocrine_pancreas1.10630254
45MP0005275_abnormal_skin_tensile1.10584671
46MP0002254_reproductive_system_inflammat1.09776468
47MP0003011_delayed_dark_adaptation1.05725658
48MP0005551_abnormal_eye_electrophysiolog1.05230067
49MP0005451_abnormal_body_composition1.01997793
50MP0003186_abnormal_redox_activity1.01104141
51MP0003646_muscle_fatigue0.99102727
52MP0001661_extended_life_span0.98195090
53MP0000013_abnormal_adipose_tissue0.97838176
54MP0003705_abnormal_hypodermis_morpholog0.97699123
55MP0005636_abnormal_mineral_homeostasis0.95635412
56MP0003959_abnormal_lean_body0.94921066
57MP0001756_abnormal_urination0.94353436
58MP0005084_abnormal_gallbladder_morpholo0.94092605
59MP0009764_decreased_sensitivity_to0.93948012
60MP0010368_abnormal_lymphatic_system0.90867355
61MP0009384_cardiac_valve_regurgitation0.90605894
62MP0005448_abnormal_energy_balance0.90358663
63MP0000751_myopathy0.89510633
64MP0006036_abnormal_mitochondrial_physio0.88093396
65MP0001501_abnormal_sleep_pattern0.86132317
66MP0000003_abnormal_adipose_tissue0.85374828
67MP0004147_increased_porphyrin_level0.84919549
68MP0004084_abnormal_cardiac_muscle0.84698336
69MP0005266_abnormal_metabolism0.83893990
70MP0003690_abnormal_glial_cell0.82698671
71MP0000230_abnormal_systemic_arterial0.81127068
72MP0005167_abnormal_blood-brain_barrier0.80649233
73MP0002269_muscular_atrophy0.80507535
74MP0003950_abnormal_plasma_membrane0.78618546
75MP0002106_abnormal_muscle_physiology0.78377810
76MP0009115_abnormal_fat_cell0.78143409
77MP0009642_abnormal_blood_homeostasis0.76754621
78MP0003633_abnormal_nervous_system0.76015048
79MP0004215_abnormal_myocardial_fiber0.75736714
80MP0004036_abnormal_muscle_relaxation0.75480881
81MP0003953_abnormal_hormone_level0.74162066
82MP0001984_abnormal_olfaction0.73689386
83MP0006054_spinal_hemorrhage0.73435445
84MP0009763_increased_sensitivity_to0.73211417
85MP0005187_abnormal_penis_morphology0.72743203
86MP0003567_abnormal_fetal_cardiomyocyte0.72039654
87MP0005377_hearing/vestibular/ear_phenot0.71985709
88MP0003878_abnormal_ear_physiology0.71985709
89MP0005620_abnormal_muscle_contractility0.71037399
90MP0002168_other_aberrant_phenotype0.70684350
91MP0001881_abnormal_mammary_gland0.70391309
92MP0001915_intracranial_hemorrhage0.69464158
93MP0000598_abnormal_liver_morphology0.68890459
94MP0005395_other_phenotype0.68295563
95MP0005330_cardiomyopathy0.67447093
96MP0005369_muscle_phenotype0.66382958
97MP0003656_abnormal_erythrocyte_physiolo0.66378705
98MP0008872_abnormal_physiological_respon0.66254485
99MP0000749_muscle_degeneration0.63800878
100MP0005386_behavior/neurological_phenoty0.63078380
101MP0004924_abnormal_behavior0.63078380
102MP0008775_abnormal_heart_ventricle0.61951496
103MP0001765_abnormal_ion_homeostasis0.61709184
104MP0006138_congestive_heart_failure0.61454079
105MP0002108_abnormal_muscle_morphology0.60713474
106MP0002972_abnormal_cardiac_muscle0.60502289
107MP0001944_abnormal_pancreas_morphology0.60202909
108MP0002060_abnormal_skin_morphology0.60025252
109MP0002132_abnormal_respiratory_system0.59629562
110MP0002909_abnormal_adrenal_gland0.59052068
111MP0005248_abnormal_Harderian_gland0.58490556
112MP0000538_abnormal_urinary_bladder0.57869647
113MP0002928_abnormal_bile_duct0.57675584
114MP0005503_abnormal_tendon_morphology0.57406475
115MP0005376_homeostasis/metabolism_phenot0.57025065
116MP0002295_abnormal_pulmonary_circulatio0.56636045
117MP0003123_paternal_imprinting0.56373827
118MP0005646_abnormal_pituitary_gland0.55933350
119MP0004272_abnormal_basement_membrane0.55020052
120MP0003631_nervous_system_phenotype0.54994456
121MP0004085_abnormal_heartbeat0.54092133
122MP0000639_abnormal_adrenal_gland0.53943756
123MP0002160_abnormal_reproductive_system0.52692831
124MP0004782_abnormal_surfactant_physiolog0.52525799
125MP0003724_increased_susceptibility_to0.52394503
126MP0001177_atelectasis0.52158064
127MP0010386_abnormal_urinary_bladder0.52149666
128MP0005385_cardiovascular_system_phenoty0.52106928
129MP0001544_abnormal_cardiovascular_syste0.52106928
130MP0004484_altered_response_of0.52067001
131MP0004087_abnormal_muscle_fiber0.50554664
132MP0003890_abnormal_embryonic-extraembry0.50447411
133MP0000604_amyloidosis0.50330463

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)5.46215829
2Abnormality of aromatic amino acid family metabolism (HP:0004338)5.17085873
3Deep venous thrombosis (HP:0002625)5.06600916
4Xanthomatosis (HP:0000991)4.84478536
5Ketosis (HP:0001946)4.73662926
6Prolonged partial thromboplastin time (HP:0003645)4.70934654
7Complement deficiency (HP:0004431)4.70439403
8Hypoglycemic coma (HP:0001325)4.68584168
9Hyperglycinuria (HP:0003108)4.59448226
10Ketoacidosis (HP:0001993)4.43054798
11Hyperlipoproteinemia (HP:0010980)4.24276698
12Abnormality of glycine metabolism (HP:0010895)4.22871663
13Abnormality of serine family amino acid metabolism (HP:0010894)4.22871663
14Hyperammonemia (HP:0001987)4.21947608
15Abnormality of monocarboxylic acid metabolism (HP:0010996)4.20850183
16Hyperglycinemia (HP:0002154)4.14688046
17Hypoalphalipoproteinemia (HP:0003233)3.97296081
18Abnormality of fatty-acid metabolism (HP:0004359)3.93348576
19Epidermoid cyst (HP:0200040)3.85209383
20Hypobetalipoproteinemia (HP:0003563)3.83165151
21Hypolipoproteinemia (HP:0010981)3.69116111
22Abnormality of glutamine family amino acid metabolism (HP:0010902)3.64290904
23Abnormality of the intrinsic pathway (HP:0010989)3.49847632
24Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.49374548
25Abnormality of the common coagulation pathway (HP:0010990)3.42745719
26Joint hemorrhage (HP:0005261)3.40014468
27Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.38505381
28Abnormality of complement system (HP:0005339)3.24836378
29Fat malabsorption (HP:0002630)3.21148088
30Abnormality of aspartate family amino acid metabolism (HP:0010899)3.12354877
31Hypoglycemic seizures (HP:0002173)3.12140999
32Conjugated hyperbilirubinemia (HP:0002908)3.11663927
33Abnormality of sulfur amino acid metabolism (HP:0004339)3.05522064
34Abnormality of purine metabolism (HP:0004352)3.01860677
35Dicarboxylic aciduria (HP:0003215)2.99237724
36Abnormality of dicarboxylic acid metabolism (HP:0010995)2.99237724
37Nephritis (HP:0000123)2.94013740
38Skin nodule (HP:0200036)2.93491266
39Gout (HP:0001997)2.88752369
40Generalized aminoaciduria (HP:0002909)2.85807656
41Abnormality of methionine metabolism (HP:0010901)2.83848800
42Metabolic acidosis (HP:0001942)2.82980678
43Abnormality of serum amino acid levels (HP:0003112)2.82510902
44Hyperinsulinemic hypoglycemia (HP:0000825)2.77952931
45Myocardial infarction (HP:0001658)2.73833540
46Fair hair (HP:0002286)2.71645269
47Delayed CNS myelination (HP:0002188)2.70776438
48Renal cortical cysts (HP:0000803)2.69202358
49Myoglobinuria (HP:0002913)2.68459000
50Hypercholesterolemia (HP:0003124)2.68072183
51Abnormality of nucleobase metabolism (HP:0010932)2.61074878
52Enlarged kidneys (HP:0000105)2.60789962
53Menorrhagia (HP:0000132)2.57334776
54Hyperglycemia (HP:0003074)2.54471619
55Acanthocytosis (HP:0001927)2.53477313
56Proximal tubulopathy (HP:0000114)2.52816337
57Osteomalacia (HP:0002749)2.50442407
58Cerebral edema (HP:0002181)2.47531872
59Hydroxyprolinuria (HP:0003080)2.46127585
60Abnormality of proline metabolism (HP:0010907)2.46127585
61Gingival bleeding (HP:0000225)2.44010542
62Steatorrhea (HP:0002570)2.41059461
63Muscle fiber inclusion bodies (HP:0100299)2.40027945
64Symptomatic seizures (HP:0011145)2.39305502
65Hepatocellular carcinoma (HP:0001402)2.38643667
66Hyperbilirubinemia (HP:0002904)2.37959782
67Oligomenorrhea (HP:0000876)2.37803514
68* Lethargy (HP:0001254)2.37201030
69Systemic lupus erythematosus (HP:0002725)2.37074412
70Rickets (HP:0002748)2.35349560
71Nemaline bodies (HP:0003798)2.32297303
72Increased purine levels (HP:0004368)2.27850987
73Hyperuricemia (HP:0002149)2.27850987
74Pancreatitis (HP:0001733)2.27603056
75Hypophosphatemic rickets (HP:0004912)2.24950206
76Exercise-induced myalgia (HP:0003738)2.23811404
77Vascular calcification (HP:0004934)2.23616654
78Thrombophlebitis (HP:0004418)2.21525316
79Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.21366370
80Vomiting (HP:0002013)2.21354008
81Cardiovascular calcification (HP:0011915)2.19014736
82Arthropathy (HP:0003040)2.17016775
83Abnormality of the nasal septum (HP:0000419)2.16459084
84Pancreatic islet-cell hyperplasia (HP:0004510)2.15798770
85Potter facies (HP:0002009)2.10954281
86Facial shape deformation (HP:0011334)2.10954281
87Joint swelling (HP:0001386)2.10111554
88Sensorimotor neuropathy (HP:0007141)2.08138327
89Mitral stenosis (HP:0001718)2.05893901
90Abnormal gallbladder morphology (HP:0012437)2.04418631
91Muscle hypertrophy of the lower extremities (HP:0008968)2.03442563
92Right ventricular cardiomyopathy (HP:0011663)2.02591276
93Poikilocytosis (HP:0004447)2.01757778
94Calf muscle hypertrophy (HP:0008981)2.00976273
95Generalized hypopigmentation of hair (HP:0011358)2.00242209
96Insulin-resistant diabetes mellitus (HP:0000831)1.99552190
97Cholelithiasis (HP:0001081)1.98150275
98Pigmentary retinal degeneration (HP:0001146)1.97780161
99Abnormal tarsal ossification (HP:0008369)1.96609269
100Blue irides (HP:0000635)1.94826827
101Neonatal onset (HP:0003623)1.91292741
102Hypochromic microcytic anemia (HP:0004840)1.90388771
103Nausea (HP:0002018)1.89597617
104Late onset (HP:0003584)1.88449872
105Increased circulating renin level (HP:0000848)1.86031904
106Hypertriglyceridemia (HP:0002155)1.82595253
107Abnormality of alanine metabolism (HP:0010916)1.82032968
108Hyperalaninemia (HP:0003348)1.82032968
109Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.82032968
110Abnormality of vitamin metabolism (HP:0100508)1.81343215
111Protuberant abdomen (HP:0001538)1.81228223
112Alkalosis (HP:0001948)1.79506837
113Abnormality of pyrimidine metabolism (HP:0004353)1.79503279
114Turricephaly (HP:0000262)1.79199792
115Spontaneous abortion (HP:0005268)1.79045735
116Recurrent gram-negative bacterial infections (HP:0005420)1.75918524
117Pulmonary embolism (HP:0002204)1.75906546
118Increased serum pyruvate (HP:0003542)1.74214804
119Abnormality of the renal cortex (HP:0011035)1.73150876
120Esophageal varix (HP:0002040)1.70702535
121Hemorrhage of the eye (HP:0011885)1.68974060
122Irritability (HP:0000737)1.68930994
123Abnormality of urine glucose concentration (HP:0011016)1.68680675
124Glycosuria (HP:0003076)1.68680675
125Brushfield spots (HP:0001088)1.67609428
126Glomerulonephritis (HP:0000099)1.67370117
127Abnormality of the gallbladder (HP:0005264)1.66890170
128Hypokalemia (HP:0002900)1.66623634
129Abnormality of potassium homeostasis (HP:0011042)1.66146030
130Respiratory distress (HP:0002098)1.65717779
131Tachypnea (HP:0002789)1.64323860
132Hyperphosphaturia (HP:0003109)1.64241851
133Purpura (HP:0000979)1.63753335
134Amyloidosis (HP:0011034)1.62440509
135Exercise-induced muscle cramps (HP:0003710)1.62142397
136Rhabdomyolysis (HP:0003201)1.62062224
137Back pain (HP:0003418)1.62041297

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK4.79380465
2INSRR4.06533179
3MAP3K134.06455981
4SIK13.69823293
5STK392.47310758
6FRK2.45602861
7ERN12.45525469
8CAMK1D2.14515499
9FGFR42.13071782
10PDK31.99969488
11PDK41.99969488
12LMTK21.82243252
13TAOK31.82067399
14LATS11.82058211
15PIK3CG1.81035596
16TRIB31.62763782
17PIK3CA1.62381530
18CAMK1G1.60400329
19PHKG21.56375103
20PHKG11.56375103
21FGFR21.52694453
22MYLK1.49129400
23PRKAA21.46739684
24EIF2AK31.46472118
25ERBB41.45455256
26MAP4K21.44933223
27PDK21.44898811
28TTN1.44792451
29OBSCN1.42214759
30ACVR1B1.41295733
31MAP2K41.36585053
32STK38L1.34615826
33MST1R1.32869011
34WNK41.32405989
35EPHA31.29074053
36SGK21.22193072
37PINK11.21571891
38PDGFRA1.20645514
39JAK11.19073945
40TIE11.18223064
41SGK31.14970218
42NEK91.11435852
43NLK1.11129732
44WNK31.08598587
45WNK11.07947699
46TRPM71.07919685
47AKT31.07254317
48BMPR1B1.07241896
49GRK11.06193342
50PRKAA11.05496903
51FLT31.04628235
52FGFR11.04360788
53MAP3K71.03787424
54MAP3K90.98054934
55PTK60.97898463
56FER0.97079506
57EEF2K0.96390021
58SGK2230.92735801
59SGK4940.92735801
60TGFBR20.91305275
61IRAK30.90937017
62PKN20.90857418
63TLK10.90133792
64CDK120.87963105
65CAMKK20.87428975
66MAPK110.85710431
67BMPR20.82004161
68MAP2K60.81965347
69ICK0.80946934
70DAPK20.80599534
71FGFR30.79902230
72CASK0.79571212
73JAK20.79299717
74PAK30.75805280
75MAPK120.73953312
76BRSK20.72372598
77RIPK10.71600434
78EPHA40.70484798
79TXK0.70115088
80NUAK10.66978375
81ERBB30.66557724
82PKN10.66132016
83MET0.65951228
84PRKCE0.65848104
85MAP3K20.65748872
86PRKACG0.64814349
87PRKCH0.64685846
88KSR20.64251665
89GRK70.64132403
90TNK20.59371965
91MAPK150.58619715
92MAPK130.58496303
93OXSR10.58155023
94TAOK20.55024342
95EIF2AK20.54944960
96PRKCZ0.54729346
97IGF1R0.53744150
98BRD40.52350798
99ROCK10.52262169
100PRKG10.51246600
101RET0.50255795
102PRKCG0.50251934
103IRAK10.50188307
104PDPK10.49830477
105CAMK40.49453891
106RPS6KB10.48988467
107MAP2K10.48661157
108DMPK0.48386204
109DDR20.48029070
110PRKD10.46968840
111GSK3A0.46795494
112MKNK20.46773429
113CAMK2G0.46730598
114CSNK1E0.46303558
115MAP3K140.46162536
116PDGFRB0.44913537
117MAP2K70.44764071
118MAPK70.44400771
119STK380.43449715
120RPS6KA30.43126792
121MAP3K40.42389415
122SGK10.41899946
123NTRK30.41100468
124MAP3K30.39121880
125ERBB20.38480657
126ADRBK20.38152835
127PRPF4B0.38123712
128EPHB20.37913774
129PRKACA0.37792780
130PRKACB0.37010817
131SIK30.36605243
132IRAK20.36594870
133TYK20.36479280
134MUSK0.36175828
135CDC42BPA0.35832064
136MAPKAPK30.35175367
137PDK10.33141011
138CSNK1D0.31860760
139CHUK0.31110577
140PRKCB0.26014543

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.56403984
2Nitrogen metabolism_Homo sapiens_hsa009103.14355324
3* Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.02454629
4Propanoate metabolism_Homo sapiens_hsa006403.00389056
5* Fatty acid degradation_Homo sapiens_hsa000712.86100173
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.75324406
7Tryptophan metabolism_Homo sapiens_hsa003802.63329221
8Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.54203142
9Arginine biosynthesis_Homo sapiens_hsa002202.50662697
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.41978871
11Butanoate metabolism_Homo sapiens_hsa006502.40626226
12Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.27321156
13* Fatty acid metabolism_Homo sapiens_hsa012122.26357567
14PPAR signaling pathway_Homo sapiens_hsa033202.22946377
15Complement and coagulation cascades_Homo sapiens_hsa046102.14504881
16Peroxisome_Homo sapiens_hsa041462.07417910
172-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.96116648
18beta-Alanine metabolism_Homo sapiens_hsa004101.87649803
19Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.82852964
20Pentose and glucuronate interconversions_Homo sapiens_hsa000401.80442353
21Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.73300923
22Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.72424391
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.70825029
24Caffeine metabolism_Homo sapiens_hsa002321.69416427
25Pyruvate metabolism_Homo sapiens_hsa006201.60963567
26Steroid hormone biosynthesis_Homo sapiens_hsa001401.51595167
27Sulfur metabolism_Homo sapiens_hsa009201.49761126
28Chemical carcinogenesis_Homo sapiens_hsa052041.47789795
29Histidine metabolism_Homo sapiens_hsa003401.46561134
30Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.45572141
31Starch and sucrose metabolism_Homo sapiens_hsa005001.44765172
32Phenylalanine metabolism_Homo sapiens_hsa003601.43126556
33Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.40504978
34Fatty acid elongation_Homo sapiens_hsa000621.36716249
35Fatty acid biosynthesis_Homo sapiens_hsa000611.35878546
36Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.35839729
37Tyrosine metabolism_Homo sapiens_hsa003501.28879217
38Retinol metabolism_Homo sapiens_hsa008301.27887342
39Carbon metabolism_Homo sapiens_hsa012001.26434125
40Bile secretion_Homo sapiens_hsa049761.25948810
41Staphylococcus aureus infection_Homo sapiens_hsa051501.25909688
42Maturity onset diabetes of the young_Homo sapiens_hsa049501.24663103
43ABC transporters_Homo sapiens_hsa020101.23784403
44Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.21697330
45Fat digestion and absorption_Homo sapiens_hsa049751.16243860
46Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.15759604
47Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.12163548
48Selenocompound metabolism_Homo sapiens_hsa004501.10762245
49Glycerolipid metabolism_Homo sapiens_hsa005611.00510472
50Drug metabolism - other enzymes_Homo sapiens_hsa009830.97258422
51Lysine degradation_Homo sapiens_hsa003100.94179621
52Arachidonic acid metabolism_Homo sapiens_hsa005900.85694168
53Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.84761114
54Arginine and proline metabolism_Homo sapiens_hsa003300.83931046
55Vitamin digestion and absorption_Homo sapiens_hsa049770.83106229
56Biosynthesis of amino acids_Homo sapiens_hsa012300.82280761
57Steroid biosynthesis_Homo sapiens_hsa001000.73202822
58One carbon pool by folate_Homo sapiens_hsa006700.69508515
59Cysteine and methionine metabolism_Homo sapiens_hsa002700.69435769
60Folate biosynthesis_Homo sapiens_hsa007900.69274741
61Insulin resistance_Homo sapiens_hsa049310.65718206
62Adipocytokine signaling pathway_Homo sapiens_hsa049200.61831192
63Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.61130336
64Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.54605226
65Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.48497610
66Glucagon signaling pathway_Homo sapiens_hsa049220.48225484
67AMPK signaling pathway_Homo sapiens_hsa041520.43584209
68Cyanoamino acid metabolism_Homo sapiens_hsa004600.41738832
69Sulfur relay system_Homo sapiens_hsa041220.40913479
70Vitamin B6 metabolism_Homo sapiens_hsa007500.39200026
71* Metabolic pathways_Homo sapiens_hsa011000.38573704
72Protein digestion and absorption_Homo sapiens_hsa049740.37184866
73Glutathione metabolism_Homo sapiens_hsa004800.35347272
74Mineral absorption_Homo sapiens_hsa049780.33596051
75Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.31870180
76Insulin signaling pathway_Homo sapiens_hsa049100.28780390
77Prion diseases_Homo sapiens_hsa050200.27624316
78Galactose metabolism_Homo sapiens_hsa000520.27348870
79alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.27227197
80Renin-angiotensin system_Homo sapiens_hsa046140.23850648
81Fructose and mannose metabolism_Homo sapiens_hsa000510.22994460
82Ether lipid metabolism_Homo sapiens_hsa005650.22936580
83Ovarian steroidogenesis_Homo sapiens_hsa049130.22388747
84Type II diabetes mellitus_Homo sapiens_hsa049300.21962979
85Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.19967982
86Pentose phosphate pathway_Homo sapiens_hsa000300.17858649
87Vascular smooth muscle contraction_Homo sapiens_hsa042700.17839700
88Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.17298732
89Serotonergic synapse_Homo sapiens_hsa047260.13361514
90Glycerophospholipid metabolism_Homo sapiens_hsa005640.13300886
91Sphingolipid metabolism_Homo sapiens_hsa006000.13112966
92Linoleic acid metabolism_Homo sapiens_hsa005910.12130876
93Pancreatic secretion_Homo sapiens_hsa049720.10684978
94Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.09646819
95Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.09269599
96Circadian rhythm_Homo sapiens_hsa047100.09046702
97Longevity regulating pathway - mammal_Homo sapiens_hsa042110.09009577
98Insulin secretion_Homo sapiens_hsa049110.08772928
99Regulation of autophagy_Homo sapiens_hsa041400.08530275
100Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.07707435
101Dilated cardiomyopathy_Homo sapiens_hsa054140.07618796
102Carbohydrate digestion and absorption_Homo sapiens_hsa049730.05666311
103Thyroid hormone synthesis_Homo sapiens_hsa049180.05098364
104Glycosaminoglycan degradation_Homo sapiens_hsa005310.03912392
105Renin secretion_Homo sapiens_hsa049240.03862987
106Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.03616206
107ECM-receptor interaction_Homo sapiens_hsa045120.03402718
108Phototransduction_Homo sapiens_hsa047440.02402648
109Amoebiasis_Homo sapiens_hsa051460.00133071
110cGMP-PKG signaling pathway_Homo sapiens_hsa04022-0.0736757
111Phosphatidylinositol signaling system_Homo sapiens_hsa04070-0.0581788
112Inositol phosphate metabolism_Homo sapiens_hsa00562-0.0358588
113Calcium signaling pathway_Homo sapiens_hsa04020-0.0299633
114FoxO signaling pathway_Homo sapiens_hsa04068-0.0242740
115Pertussis_Homo sapiens_hsa05133-0.0082390
116Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960-0.0031808

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