ACAN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the aggrecan/versican proteoglycan family. The encoded protein is an integral part of the extracellular matrix in cartilagenous tissue and it withstands compression in cartilage. Mutations in this gene may be involved in skeletal dysplasia and spinal degeneration. Multiple alternatively spliced transcript variants that encode different protein isoforms have been observed in this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* cell aggregation (GO:0098743)9.86729045
2* cartilage condensation (GO:0001502)9.86729045
3notochord development (GO:0030903)9.43626431
4* chondrocyte development (GO:0002063)8.89539079
5limb bud formation (GO:0060174)8.62316136
6negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)8.06343633
7positive regulation of extracellular matrix organization (GO:1903055)7.92630436
8* keratan sulfate catabolic process (GO:0042340)7.47731372
9* collagen fibril organization (GO:0030199)6.96924648
10cartilage development (GO:0051216)6.94327412
11replacement ossification (GO:0036075)6.76881766
12endochondral ossification (GO:0001958)6.76881766
13positive regulation of chondrocyte differentiation (GO:0032332)6.67402979
14chondroitin sulfate biosynthetic process (GO:0030206)6.64163624
15sequestering of extracellular ligand from receptor (GO:0035581)6.54081619
16protein heterotrimerization (GO:0070208)6.53982643
17chondrocyte differentiation (GO:0002062)6.45871303
18embryonic skeletal joint morphogenesis (GO:0060272)6.41231102
19hypotonic response (GO:0006971)5.89152525
20collagen catabolic process (GO:0030574)5.83119301
21nucleotide-sugar biosynthetic process (GO:0009226)5.76368702
22* proteoglycan metabolic process (GO:0006029)5.60925348
23positive regulation of cartilage development (GO:0061036)5.58126151
24collagen metabolic process (GO:0032963)5.54115018
25iron ion import (GO:0097286)5.41314493
26sphingomyelin metabolic process (GO:0006684)5.40867786
27regulation of extracellular matrix disassembly (GO:0010715)5.36061333
28multicellular organismal catabolic process (GO:0044243)5.35934308
29endothelial cell morphogenesis (GO:0001886)5.31582965
30multicellular organismal macromolecule metabolic process (GO:0044259)5.20937359
31peptidyl-proline hydroxylation (GO:0019511)5.18477291
32type B pancreatic cell proliferation (GO:0044342)5.13402062
33lipopolysaccharide biosynthetic process (GO:0009103)5.12326131
34regulation of response to osmotic stress (GO:0047484)5.07041390
35stress fiber assembly (GO:0043149)4.99458795
36* skeletal system development (GO:0001501)4.98258771
37multicellular organismal metabolic process (GO:0044236)4.95669329
38extracellular fibril organization (GO:0043206)4.83057513
39protein retention in ER lumen (GO:0006621)4.82464849
40dermatan sulfate metabolic process (GO:0030205)4.75017845
41regulation of branching involved in salivary gland morphogenesis (GO:0060693)4.69557487
42kidney mesenchyme development (GO:0072074)4.66776818
43cellular glucuronidation (GO:0052695)4.61671284
44regulation of extracellular matrix organization (GO:1903053)4.61006300
45regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)4.59804949
46regulation of chondrocyte differentiation (GO:0032330)4.58212691
47chondrocyte proliferation (GO:0035988)4.56533624
48extracellular matrix assembly (GO:0085029)4.52496067
49maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.50192236
50actin filament depolymerization (GO:0030042)4.45287857
51neuron remodeling (GO:0016322)4.43361809
52UDP-N-acetylglucosamine metabolic process (GO:0006047)4.42638747
53metanephric mesenchyme development (GO:0072075)4.41711362
54retina vasculature morphogenesis in camera-type eye (GO:0061299)4.37630536
55connective tissue development (GO:0061448)4.32773660
56lipopolysaccharide metabolic process (GO:0008653)4.32320886
57regulation of cartilage development (GO:0061035)4.31963254
58regulation of plasminogen activation (GO:0010755)4.29445539
59cell migration involved in heart development (GO:0060973)4.29012049
60basement membrane organization (GO:0071711)4.28417021
61positive regulation of hormone biosynthetic process (GO:0046886)4.18707806
62cellular response to BMP stimulus (GO:0071773)4.17910087
63response to BMP (GO:0071772)4.17910087
64smooth muscle tissue development (GO:0048745)4.13927359
65fibril organization (GO:0097435)4.13494720
66regulation of integrin-mediated signaling pathway (GO:2001044)4.10637334
67protein hydroxylation (GO:0018126)4.10137555
68uronic acid metabolic process (GO:0006063)4.07729582
69glucuronate metabolic process (GO:0019585)4.07729582
70glomerular basement membrane development (GO:0032836)4.06792618
71chondroitin sulfate metabolic process (GO:0030204)4.03165843
72* extracellular matrix disassembly (GO:0022617)3.97711570
73substrate-dependent cell migration (GO:0006929)3.94765793
74cell adhesion mediated by integrin (GO:0033627)3.93549803
75extracellular regulation of signal transduction (GO:1900115)3.93160249
76extracellular negative regulation of signal transduction (GO:1900116)3.93160249
77negative regulation of gluconeogenesis (GO:0045721)3.91906687
78regulation of gonadotropin secretion (GO:0032276)3.91612607
79regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.84902908
80hyperosmotic salinity response (GO:0042538)3.83184257
81response to gravity (GO:0009629)3.81983854
82negative regulation of cartilage development (GO:0061037)3.80662995
83embryonic viscerocranium morphogenesis (GO:0048703)3.80356373
84ossification (GO:0001503)3.79978021
85substrate adhesion-dependent cell spreading (GO:0034446)3.73353641
86myelin assembly (GO:0032288)3.72187810
87* glycosaminoglycan biosynthetic process (GO:0006024)3.71470263
88endocardial cushion morphogenesis (GO:0003203)3.70284529
89bone trabecula formation (GO:0060346)3.67558705
90* aminoglycan biosynthetic process (GO:0006023)3.65437578
91chondroitin sulfate catabolic process (GO:0030207)3.61333491
92COPII vesicle coating (GO:0048208)3.57605563
93* glycoprotein metabolic process (GO:0009100)3.55402462
94tooth mineralization (GO:0034505)3.49489724
95lymphangiogenesis (GO:0001946)3.48623293
96heparan sulfate proteoglycan biosynthetic process (GO:0015012)3.48282410
97* extracellular matrix organization (GO:0030198)3.46488429
98COPI coating of Golgi vesicle (GO:0048205)3.45946653
99Golgi transport vesicle coating (GO:0048200)3.45946653
100* extracellular structure organization (GO:0043062)3.45456524
101nucleotide-sugar metabolic process (GO:0009225)3.44780592
102negative regulation of smooth muscle cell migration (GO:0014912)3.40202478
103positive regulation of blood vessel endothelial cell migration (GO:0043536)3.39672837
104negative regulation of chondrocyte differentiation (GO:0032331)3.39416848
105* keratan sulfate biosynthetic process (GO:0018146)3.35545150
106endodermal cell differentiation (GO:0035987)3.33365016
107appendage development (GO:0048736)3.30802478
108limb development (GO:0060173)3.30802478
109regulation of steroid hormone biosynthetic process (GO:0090030)3.30370248
110somite development (GO:0061053)3.29095059
111regulation of bone mineralization (GO:0030500)3.28982583
112bone development (GO:0060348)3.28947592
113wound healing, spreading of epidermal cells (GO:0035313)3.26794645
114positive regulation of fibroblast migration (GO:0010763)3.25032814
115negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.23280639
116vascular endothelial growth factor signaling pathway (GO:0038084)3.20998119
117peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.18952985
118short-term memory (GO:0007614)3.18818576
119sprouting angiogenesis (GO:0002040)3.16896744
120negative regulation of smooth muscle cell differentiation (GO:0051151)3.14392962
121detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.14362668
122heparan sulfate proteoglycan metabolic process (GO:0030201)3.12660661
123positive regulation of osteoblast proliferation (GO:0033690)3.11658250
124negative regulation of BMP signaling pathway (GO:0030514)3.08035711
125epithelial cell-cell adhesion (GO:0090136)3.07585666
126positive regulation of transforming growth factor beta receptor signaling pathway (GO:0030511)3.03650102
127blood vessel remodeling (GO:0001974)3.02418789
128regulation of biomineral tissue development (GO:0070167)3.00151648
129dermatan sulfate biosynthetic process (GO:0030208)2.97334786
130positive regulation of hormone metabolic process (GO:0032352)2.96336175
131positive regulation of neurological system process (GO:0031646)2.94789127
132artery morphogenesis (GO:0048844)2.91395373
133venous blood vessel morphogenesis (GO:0048845)2.91379154
134otic vesicle formation (GO:0030916)2.90350980
135skin morphogenesis (GO:0043589)2.86593786
136negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.86015670
137* glycosaminoglycan catabolic process (GO:0006027)2.85014531
138cell-substrate junction assembly (GO:0007044)2.84977310
139positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.84779149
140glomerular visceral epithelial cell development (GO:0072015)2.84632693
141positive regulation of collagen biosynthetic process (GO:0032967)2.83969074
142regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.83728207
143positive regulation of stem cell differentiation (GO:2000738)2.81583638
144mesenchyme morphogenesis (GO:0072132)2.81249689
145cell migration involved in sprouting angiogenesis (GO:0002042)2.81029589
146positive regulation of endothelial cell apoptotic process (GO:2000353)2.79356041
147positive regulation of endothelial cell differentiation (GO:0045603)2.78857066
148regulation of type B pancreatic cell apoptotic process (GO:2000674)2.77771194
149cell proliferation involved in metanephros development (GO:0072203)2.76073146
150* keratan sulfate metabolic process (GO:0042339)2.76062973
151adhesion of symbiont to host (GO:0044406)2.75576745
152adhesion of symbiont to host cell (GO:0044650)2.75498170
153virion attachment to host cell (GO:0019062)2.75498170
154positive regulation of male gonad development (GO:2000020)2.74805194
155bone mineralization (GO:0030282)2.74465693
156negative regulation of fatty acid transport (GO:2000192)2.74074723
157negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.72854419
158negative regulation of nitric-oxide synthase activity (GO:0051001)2.71992986
159vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.70552207
160cell-substrate adhesion (GO:0031589)2.69246397
161cardiac right ventricle morphogenesis (GO:0003215)2.69061382
162negative regulation of endothelial cell proliferation (GO:0001937)2.68918197
163blood vessel morphogenesis (GO:0048514)2.68706671
164actin filament bundle assembly (GO:0051017)2.66735542
165actin filament bundle organization (GO:0061572)2.66735542
166negative regulation of embryonic development (GO:0045992)2.65937976
167positive regulation of collagen metabolic process (GO:0010714)2.64870577
168positive regulation of axon extension (GO:0045773)2.64829421
169cartilage development involved in endochondral bone morphogenesis (GO:0060351)14.6978829

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human7.78785894
2AR_21572438_ChIP-Seq_LNCaP_Human5.50091926
3GATA1_22025678_ChIP-Seq_K562_Human4.68516198
4TP63_17297297_ChIP-ChIP_HaCaT_Human4.07132513
5SMAD_19615063_ChIP-ChIP_OVARY_Human3.48568118
6ESR1_21235772_ChIP-Seq_MCF-7_Human3.29319461
7HIF1A_21447827_ChIP-Seq_MCF-7_Human2.93140305
8EP300_21415370_ChIP-Seq_HL-1_Mouse2.64166116
9PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.42472704
10RARG_19884340_ChIP-ChIP_MEFs_Mouse2.32483941
11ESR2_21235772_ChIP-Seq_MCF-7_Human2.31567958
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.27888168
13EED_16625203_ChIP-ChIP_MESCs_Mouse2.23120337
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.20031266
15TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.03566106
16WT1_19549856_ChIP-ChIP_CCG9911_Human2.02916216
17HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.96576099
18RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.95147934
19CJUN_26792858_Chip-Seq_BT549_Human1.94378359
20FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.82084031
21TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.81036463
22GBX2_23144817_ChIP-Seq_PC3_Human1.76754746
23TP53_16413492_ChIP-PET_HCT116_Human1.74292805
24CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.69399935
25ZNF217_24962896_ChIP-Seq_MCF-7_Human1.67328952
26EZH2_18974828_ChIP-Seq_MESCs_Mouse1.64984427
27RNF2_18974828_ChIP-Seq_MESCs_Mouse1.64984427
28ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.60379649
29PCGF2_27294783_Chip-Seq_ESCs_Mouse1.59947082
30ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.58209109
31SALL1_21062744_ChIP-ChIP_HESCs_Human1.57423678
32SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.55528822
33SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.55033252
34MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.53175868
35FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.51227414
36CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.50744780
37TP53_18474530_ChIP-ChIP_U2OS_Human1.48531496
38SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.48444557
39EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.46997859
40RXR_22108803_ChIP-Seq_LS180_Human1.46400762
41JARID2_20075857_ChIP-Seq_MESCs_Mouse1.46067264
42PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.45098212
43TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.45045628
44JARID2_20064375_ChIP-Seq_MESCs_Mouse1.41494668
45PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.41358466
46JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.39345819
47TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.39060890
48GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.32246029
49IKZF1_21737484_ChIP-ChIP_HCT116_Human1.31289124
50FLI1_27457419_Chip-Seq_LIVER_Mouse1.31102380
51VDR_24787735_ChIP-Seq_THP-1_Human1.30627770
52ZFP57_27257070_Chip-Seq_ESCs_Mouse1.27992836
53NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.26607691
54NRF2_20460467_ChIP-Seq_MEFs_Mouse1.26607691
55TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25957120
56POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.25957120
57SOX2_20726797_ChIP-Seq_SW620_Human1.24895951
58WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.22569934
59GATA2_21666600_ChIP-Seq_HMVEC_Human1.21837468
60ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.20375597
61SUZ12_27294783_Chip-Seq_ESCs_Mouse1.20078053
62SOX9_24532713_ChIP-Seq_HFSC_Mouse1.19466918
63PCGF2_27294783_Chip-Seq_NPCs_Mouse1.19112888
64TP53_20018659_ChIP-ChIP_R1E_Mouse1.18799667
65RNF2_27304074_Chip-Seq_ESCs_Mouse1.18784758
66RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.17460390
67SALL4_18804426_ChIP-ChIP_XEN_Mouse1.16826790
68* TP53_23651856_ChIP-Seq_MEFs_Mouse1.16683733
69BRD4_25478319_ChIP-Seq_HGPS_Human1.16593619
70KDM2B_26808549_Chip-Seq_K562_Human1.15587591
71CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.15408866
72SA1_22415368_ChIP-Seq_MEFs_Mouse1.15199352
73SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.11953920
74NFIB_24661679_ChIP-Seq_LUNG_Mouse1.11878195
75SUZ12_27294783_Chip-Seq_NPCs_Mouse1.09683561
76ELK1_22589737_ChIP-Seq_MCF10A_Human1.09490247
77GATA3_24758297_ChIP-Seq_MCF-7_Human1.09214475
78TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.08117876
79ISL1_27105846_Chip-Seq_CPCs_Mouse1.07973021
80DROSHA_22980978_ChIP-Seq_HELA_Human1.06928407
81SMC1_22415368_ChIP-Seq_MEFs_Mouse1.05727625
82TP53_22127205_ChIP-Seq_IMR90_Human1.05091010
83EZH2_27294783_Chip-Seq_ESCs_Mouse1.04520941
84FOXO3_23340844_ChIP-Seq_DLD1_Human1.03794130
85JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.03673159
86SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.03325545
87SMAD3_21741376_ChIP-Seq_EPCs_Human1.02418639
88BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.02288768
89EGR1_19032775_ChIP-ChIP_M12_Human1.02045809
90* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.01974307
91ESR1_20079471_ChIP-ChIP_T-47D_Human1.01678912
92AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.01595056
93SMC3_22415368_ChIP-Seq_MEFs_Mouse1.00851379
94CLOCK_20551151_ChIP-Seq_293T_Human1.00821282
95SMAD4_21799915_ChIP-Seq_A2780_Human1.00716576
96SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.99694871
97ERG_21242973_ChIP-ChIP_JURKAT_Human0.99276032
98SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.98182708
99PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.97740030
100SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.96275109
101SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.96275109
102WT1_25993318_ChIP-Seq_PODOCYTE_Human0.96100584
103EZH2_27294783_Chip-Seq_NPCs_Mouse0.95840324
104FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.95641510
105CDX2_20551321_ChIP-Seq_CACO-2_Human0.95482643
106* MTF2_20144788_ChIP-Seq_MESCs_Mouse0.94935843
107FOXM1_26456572_ChIP-Seq_MCF-7_Human0.94363522
108CDX2_19796622_ChIP-Seq_MESCs_Mouse0.92899255
109SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.92560772
110UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.91225360
111NR3C1_23031785_ChIP-Seq_PC12_Mouse0.90945908
112NFE2_27457419_Chip-Seq_LIVER_Mouse0.90570563
113PIAS1_25552417_ChIP-Seq_VCAP_Human0.90478777
114KDM2B_26808549_Chip-Seq_REH_Human0.89993406
115PPARD_21283829_ChIP-Seq_MYOFIBROBLAST_Human0.89646635
116P300_27058665_Chip-Seq_ZR-75-30cells_Human0.89366340
117NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.88533915
118OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.88423799
119EZH2_22144423_ChIP-Seq_EOC_Human0.88294201
120* TBX20_22328084_ChIP-Seq_HEART_Mouse0.87609793
121* TBX20_22080862_ChIP-Seq_HEART_Mouse0.87609793
122TBX3_20139965_ChIP-Seq_ESCs_Mouse0.87390069
123AHR_22903824_ChIP-Seq_MCF-7_Human0.86892642
124TBX3_20139965_ChIP-Seq_MESCs_Mouse0.86010368
125NR3C1_21868756_ChIP-Seq_MCF10A_Human0.85094908
126PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.84933699
127PPAR_26484153_Chip-Seq_NCI-H1993_Human0.84564799
128TOP2B_26459242_ChIP-Seq_MCF-7_Human0.84371523
129RING1B_27294783_Chip-Seq_ESCs_Mouse0.83999079
130TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.83912021
131KLF5_20875108_ChIP-Seq_MESCs_Mouse0.83046446
132JUN_21703547_ChIP-Seq_K562_Human0.82969011
133KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.82888461
134ARNT_22903824_ChIP-Seq_MCF-7_Human0.82614180
135SOX2_21211035_ChIP-Seq_LN229_Gbm0.82333802
136EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.81898170
137SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.81134785

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005503_abnormal_tendon_morphology6.23183123
2MP0002933_joint_inflammation6.06895514
3MP0003646_muscle_fatigue5.34860775
4MP0009250_abnormal_appendicular_skeleto4.33419000
5* MP0004134_abnormal_chest_morphology4.21041660
6* MP0000163_abnormal_cartilage_morphology4.20558696
7* MP0002282_abnormal_trachea_morphology3.92804160
8MP0009780_abnormal_chondrocyte_physiolo3.59505506
9* MP0002115_abnormal_skeleton_extremities3.41532119
10MP0005257_abnormal_intraocular_pressure2.93559578
11MP0003283_abnormal_digestive_organ2.89047360
12MP0002896_abnormal_bone_mineralization2.88235942
13* MP0002113_abnormal_skeleton_development2.84831789
14MP0002089_abnormal_postnatal_growth/wei2.84617530
15MP0005508_abnormal_skeleton_morphology2.79118293
16MP0001299_abnormal_eye_distance/2.61441147
17MP0000767_abnormal_smooth_muscle2.59375952
18MP0000013_abnormal_adipose_tissue2.57611940
19MP0006054_spinal_hemorrhage2.56280972
20MP0010368_abnormal_lymphatic_system2.55866184
21MP0000751_myopathy2.47600632
22MP0003123_paternal_imprinting2.34426004
23* MP0002109_abnormal_limb_morphology2.29974996
24* MP0005390_skeleton_phenotype2.22532762
25MP0005275_abnormal_skin_tensile2.19846551
26MP0002108_abnormal_muscle_morphology2.15312664
27MP0002909_abnormal_adrenal_gland2.08074017
28MP0009384_cardiac_valve_regurgitation2.05745019
29MP0008438_abnormal_cutaneous_collagen2.04889602
30* MP0000762_abnormal_tongue_morphology2.02180581
31MP0003122_maternal_imprinting2.00027425
32MP0004272_abnormal_basement_membrane1.84980352
33* MP0001533_abnormal_skeleton_physiology1.77931394
34MP0001542_abnormal_bone_strength1.76386539
35* MP0003795_abnormal_bone_structure1.74129235
36* MP0002116_abnormal_craniofacial_bone1.68863302
37MP0000049_abnormal_middle_ear1.67513481
38MP0003705_abnormal_hypodermis_morpholog1.63319867
39MP0003950_abnormal_plasma_membrane1.58403522
40MP0005171_absent_coat_pigmentation1.58343349
41MP0010386_abnormal_urinary_bladder1.56557511
42* MP0003755_abnormal_palate_morphology1.54367161
43MP0002233_abnormal_nose_morphology1.51918002
44MP0002295_abnormal_pulmonary_circulatio1.49090789
45MP0000569_abnormal_digit_pigmentation1.47338160
46* MP0001270_distended_abdomen1.46319445
47MP0002249_abnormal_larynx_morphology1.43673270
48* MP0000432_abnormal_head_morphology1.41997921
49MP0010030_abnormal_orbit_morphology1.39206651
50MP0003279_aneurysm1.37318564
51MP0003121_genomic_imprinting1.33799082
52MP0002932_abnormal_joint_morphology1.28033170
53MP0005595_abnormal_vascular_smooth1.26101551
54MP0003935_abnormal_craniofacial_develop1.26063462
55MP0004197_abnormal_fetal_growth/weight/1.25735259
56MP0002998_abnormal_bone_remodeling1.25235855
57* MP0002114_abnormal_axial_skeleton1.20918099
58MP0005023_abnormal_wound_healing1.17533186
59MP0003787_abnormal_imprinting1.12375773
60MP0003656_abnormal_erythrocyte_physiolo1.06970081
61MP0008004_abnormal_stomach_pH1.05907240
62* MP0002111_abnormal_tail_morphology1.05484296
63MP0002254_reproductive_system_inflammat1.02526496
64MP0001879_abnormal_lymphatic_vessel1.01022957
65MP0000462_abnormal_digestive_system1.00979756
66MP0000566_synostosis1.00399844
67MP0005381_digestive/alimentary_phenotyp1.00312414
68MP0003566_abnormal_cell_adhesion0.99332222
69MP0000003_abnormal_adipose_tissue0.98800753
70MP0000343_altered_response_to0.97795386
71MP0004858_abnormal_nervous_system0.96933371
72MP0002133_abnormal_respiratory_system0.96478123
73MP0005388_respiratory_system_phenotype0.96478123
74MP0003091_abnormal_cell_migration0.90959014
75MP0002163_abnormal_gland_morphology0.90217368
76MP0000428_abnormal_craniofacial_morphol0.89830122
77MP0001663_abnormal_digestive_system0.87115947
78MP0002168_other_aberrant_phenotype0.86006998
79MP0009053_abnormal_anal_canal0.83584375
80MP0000538_abnormal_urinary_bladder0.82223460
81MP0003942_abnormal_urinary_system0.81984167
82MP0000230_abnormal_systemic_arterial0.81015205
83MP0001177_atelectasis0.80842990
84MP0004883_abnormal_blood_vessel0.79354158
85MP0003385_abnormal_body_wall0.79251208
86MP0005076_abnormal_cell_differentiation0.78850103
87MP0004484_altered_response_of0.76896654
88MP0005164_abnormal_response_to0.76855425
89MP0001958_emphysema0.74474951
90MP0004145_abnormal_muscle_electrophysio0.74203325
91* MP0003937_abnormal_limbs/digits/tail_de0.73107391
92MP0002735_abnormal_chemical_nociception0.72639302
93MP0010352_gastrointestinal_tract_polyps0.68950202
94MP0004084_abnormal_cardiac_muscle0.68805416
95MP0003252_abnormal_bile_duct0.68080770
96MP0001614_abnormal_blood_vessel0.65840864
97MP0005197_abnormal_uvea_morphology0.65721744
98MP0005620_abnormal_muscle_contractility0.65386716
99MP0001348_abnormal_lacrimal_gland0.63808365
100MP0003195_calcinosis0.63805187
101MP0005248_abnormal_Harderian_gland0.62995752
102MP0002938_white_spotting0.62071163
103MP0001286_abnormal_eye_development0.60893355
104MP0001243_abnormal_dermal_layer0.59771561
105MP0005369_muscle_phenotype0.57892101
106MP0009697_abnormal_copulation0.57584009
107MP0003119_abnormal_digestive_system0.57582876
108MP0001915_intracranial_hemorrhage0.57234034
109MP0002234_abnormal_pharynx_morphology0.55975672
110MP0000733_abnormal_muscle_development0.55459813
111MP0003448_altered_tumor_morphology0.51789678
112MP0005623_abnormal_meninges_morphology0.51486947
113* MP0001943_abnormal_respiration0.49597641
114* MP0001963_abnormal_hearing_physiology0.48311454
115MP0004264_abnormal_extraembryonic_tissu0.48240135
116MP0004233_abnormal_muscle_weight0.47518798
117* MP0001175_abnormal_lung_morphology0.46893064
118MP0003045_fibrosis0.45878758
119MP0002092_abnormal_eye_morphology0.45036575
120MP0002925_abnormal_cardiovascular_devel0.44985829
121MP0000465_gastrointestinal_hemorrhage0.44913527
122MP0003115_abnormal_respiratory_system0.44712206
123MP0000749_muscle_degeneration0.42203324
124MP0005165_increased_susceptibility_to0.41385038
125MP0010771_integument_phenotype0.40391345
126MP0004036_abnormal_muscle_relaxation0.40183942
127MP0003941_abnormal_skin_development0.39325671
128MP0002060_abnormal_skin_morphology0.38851253
129MP0000647_abnormal_sebaceous_gland0.36644461
130MP0000516_abnormal_urinary_system0.36481403
131MP0005367_renal/urinary_system_phenotyp0.36481403
132MP0001849_ear_inflammation0.35859849
133MP0000534_abnormal_ureter_morphology0.35564698
134MP0001340_abnormal_eyelid_morphology0.33738005
135MP0002877_abnormal_melanocyte_morpholog0.33525329
136MP0002128_abnormal_blood_circulation0.33508986
137MP0000750_abnormal_muscle_regeneration0.32361885
138MP0000759_abnormal_skeletal_muscle0.32292699
139MP0005193_abnormal_anterior_eye0.32279273
140MP0001873_stomach_inflammation0.31711256
141MP0002106_abnormal_muscle_physiology0.31077531
142* MP0002081_perinatal_lethality0.30933241
143MP0000537_abnormal_urethra_morphology0.30369260

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)9.95289050
2Epiphyseal dysplasia (HP:0002656)9.85330560
3Irregular epiphyses (HP:0010582)9.17676098
4Small epiphyses (HP:0010585)7.18366464
5Vitreoretinal degeneration (HP:0000655)7.12295388
6Protrusio acetabuli (HP:0003179)6.87385650
7Hypoplastic ischia (HP:0003175)6.56589765
8Aortic dissection (HP:0002647)6.41958599
9Delayed epiphyseal ossification (HP:0002663)5.95169309
10Abnormal tarsal ossification (HP:0008369)5.91718336
11Cupped ribs (HP:0000887)5.81900971
12Abnormality of the ischium (HP:0003174)5.79647582
13Aortic aneurysm (HP:0004942)5.69676103
14Aplasia/Hypoplasia of the pubic bone (HP:0009104)5.64775175
15Soft skin (HP:0000977)5.62024424
16Metaphyseal cupping (HP:0003021)5.23566230
17Flat acetabular roof (HP:0003180)5.22839176
18Abnormality of dentin (HP:0010299)5.20708485
19* Genu varum (HP:0002970)4.94863906
20Bladder diverticulum (HP:0000015)4.91165552
21Mild short stature (HP:0003502)4.72725184
22Spondylolisthesis (HP:0003302)4.61727108
23Aortic regurgitation (HP:0001659)4.53279048
24Abnormality of the vertebral endplates (HP:0005106)4.51122119
25Flattened epiphyses (HP:0003071)4.35778682
26Neonatal short-limb short stature (HP:0008921)4.34559778
27Abnormal foot bone ossification (HP:0010675)4.33308932
28Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)4.20749716
29Absent epiphyses (HP:0010577)4.20749716
30* Abnormality of femoral epiphyses (HP:0006499)4.19551515
31* Abnormality involving the epiphyses of the lower limbs (HP:0006500)4.19551515
32Fragile skin (HP:0001030)4.19268889
33Genu recurvatum (HP:0002816)4.14566083
34Irregular vertebral endplates (HP:0003301)4.13113406
35Bowel diverticulosis (HP:0005222)4.06267925
36Short femoral neck (HP:0100864)4.04467949
37Peritonitis (HP:0002586)3.94720913
38Metaphyseal dysplasia (HP:0100255)3.93901421
39Follicular hyperkeratosis (HP:0007502)3.90869202
40Arthropathy (HP:0003040)3.89146319
41Cerebral aneurysm (HP:0004944)3.87740883
42Redundant skin (HP:0001582)3.87501896
43* Flat capital femoral epiphysis (HP:0003370)3.84916733
44* Abnormality of the epiphysis of the femoral head (HP:0010574)3.79599897
45Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)3.74756679
46Enlarged epiphyses (HP:0010580)3.72536540
47Ankle contracture (HP:0006466)3.68658409
48Blue sclerae (HP:0000592)3.67679988
49Atrophic scars (HP:0001075)3.63871673
50Metaphyseal irregularity (HP:0003025)3.63436413
51* Osteoarthritis (HP:0002758)3.62287103
52Dilatation of the ascending aorta (HP:0005111)3.51223550
53Coxa vara (HP:0002812)3.48905189
54* Abnormality of the femoral head (HP:0003368)3.47730084
55Abnormality of the proximal phalanges of the hand (HP:0009834)3.43138851
56Pulmonary artery stenosis (HP:0004415)3.42080296
57Renal duplication (HP:0000075)3.41829087
58Abnormality of carpal bone ossification (HP:0006257)3.41473096
59Flat cornea (HP:0007720)3.40107032
60Type 1 muscle fiber predominance (HP:0003803)3.37356754
61Carpal bone hypoplasia (HP:0001498)3.37319360
62Abnormality of the pubic bones (HP:0003172)3.35480174
63Vascular tortuosity (HP:0004948)3.33434174
64Mitral valve prolapse (HP:0001634)3.31116963
65Abnormal vertebral ossification (HP:0100569)3.31029020
66Wormian bones (HP:0002645)3.27548752
67Abnormality of the phalanges of the 2nd finger (HP:0009541)3.27511742
68Mitral regurgitation (HP:0001653)3.23344009
69Broad metatarsal (HP:0001783)3.22003971
70Aortic valve stenosis (HP:0001650)3.18907367
71Shallow orbits (HP:0000586)3.14136005
72Limited hip movement (HP:0008800)3.10522226
73Beaking of vertebral bodies (HP:0004568)3.08587342
74Protuberant abdomen (HP:0001538)3.08490217
75Arterial tortuosity (HP:0005116)3.08112774
76Spinal rigidity (HP:0003306)3.03281914
77Aplasia/hypoplasia of the femur (HP:0005613)3.02329819
78Vertebral clefting (HP:0008428)3.02222351
79Hyperextensible skin (HP:0000974)3.01690271
80Limited elbow extension (HP:0001377)3.01267017
81* Platyspondyly (HP:0000926)2.97756505
82Spinal cord compression (HP:0002176)2.96537381
83Thoracolumbar scoliosis (HP:0002944)2.94059981
84Abnormal delivery (HP:0001787)2.93354331
85Cervical subluxation (HP:0003308)2.90512625
86Broad ribs (HP:0000885)2.87774460
87Overgrowth (HP:0001548)2.85231531
88Ovoid vertebral bodies (HP:0003300)2.83756549
89* Joint laxity (HP:0001388)2.82317804
90Hip contracture (HP:0003273)2.80410118
91Abnormal hand bone ossification (HP:0010660)2.76243423
92Hypoplasia of the odontoid process (HP:0003311)2.74251697
93Slender build (HP:0001533)2.74092234
94* Waddling gait (HP:0002515)2.71838162
95Biconcave vertebral bodies (HP:0004586)2.71272062
96Abnormal ossification of hand bones (HP:0005921)2.69281629
97Wide anterior fontanel (HP:0000260)2.67796701
98Stillbirth (HP:0003826)2.67733834
99Aplasia/Hypoplasia involving the pelvis (HP:0009103)2.67705244
100Hyperacusis (HP:0010780)2.63864857
101Renovascular hypertension (HP:0100817)2.62927124
102Round ear (HP:0100830)2.59003447
103Increased corneal curvature (HP:0100692)2.57974486
104Keratoconus (HP:0000563)2.57974486
105Ectopia lentis (HP:0001083)2.54448034
106Glossoptosis (HP:0000162)2.53286768
107Elfin facies (HP:0004428)2.52560202
108Infantile muscular hypotonia (HP:0008947)2.50388986
109Mitral stenosis (HP:0001718)2.48659377
110Flared iliac wings (HP:0002869)2.48636146
111Short middle phalanx of finger (HP:0005819)2.47210603
112Premature skin wrinkling (HP:0100678)2.45810742
113Fibular hypoplasia (HP:0003038)2.44518320
114Absent frontal sinuses (HP:0002688)2.43551945
115Thin ribs (HP:0000883)2.38644477
116Abnormality of the 2nd finger (HP:0004100)2.37570002
117Disproportionate tall stature (HP:0001519)2.36106799
118Overriding aorta (HP:0002623)2.33950630
119Aneurysm (HP:0002617)2.29479240
120Abnormality of the odontoid process (HP:0003310)2.26640877
121Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.26364947
122Hallux valgus (HP:0001822)2.25640698
123Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.23294771
124Abnormality of the middle phalanges of the toes (HP:0010183)2.22952210
125* Lumbar hyperlordosis (HP:0002938)2.22876190
126Delayed gross motor development (HP:0002194)2.22357970
127Abnormality of incisor morphology (HP:0011063)2.21876718
128Pulmonic stenosis (HP:0001642)2.20369113
129Abnormality of the vitreous humor (HP:0004327)2.17357279
130Abnormality of the lumbar spine (HP:0100712)2.17015542
131Flared metaphyses (HP:0003015)2.16695722
132Deviation of the hallux (HP:0010051)2.16506297
133Wrist flexion contracture (HP:0001239)2.15843849
134Radial bowing (HP:0002986)2.14914330
135Venous insufficiency (HP:0005293)2.14737181
136Hypoplastic pelvis (HP:0008839)2.13186478
137Disproportionate short-trunk short stature (HP:0003521)2.13132820
138Hypoplastic ilia (HP:0000946)2.12009913
139Inguinal hernia (HP:0000023)2.11695289
140Hypoplasia of the iris (HP:0007676)2.11240490
141Abnormality of the acetabulum (HP:0003170)2.10990536
142Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.09445474
143* Micromelia (HP:0002983)2.09443066
144Long clavicles (HP:0000890)2.06945645
145Vertebral hypoplasia (HP:0008417)2.06745731
146Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.06745731
147Ulnar deviation of the wrist (HP:0003049)2.06332513
148Delayed closure of the anterior fontanelle (HP:0001476)2.06320047
149Coronal craniosynostosis (HP:0004440)2.04325626
150Tibial bowing (HP:0002982)2.02837347
151Aplasia/Hypoplasia involving the vertebral column (HP:0008518)2.01743621
152Mixed hearing impairment (HP:0000410)2.01546997
153Abnormality of the phalanges of the 5th finger (HP:0004213)2.00915586
154Aplasia/Hypoplasia of the middle phalanges of the hand (HP:0009843)1.98986085
155Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.97942757
156Abnormality of the phalanges of the hallux (HP:0010057)1.95887766
157* Barrel-shaped chest (HP:0001552)1.95749034
158Congenital hip dislocation (HP:0001374)1.95483847
159Thin bony cortex (HP:0002753)1.92699739
160Megalocornea (HP:0000485)1.91919555
161Increased variability in muscle fiber diameter (HP:0003557)1.90236694
162Elbow flexion contracture (HP:0002987)1.89555204
163Insomnia (HP:0100785)1.88824787
164Abnormality of the middle phalanges of the hand (HP:0009833)1.88409537
165Hypoventilation (HP:0002791)1.87183577
166Cardiovascular calcification (HP:0011915)1.86550848
167Persistence of primary teeth (HP:0006335)1.86528625
168Short ribs (HP:0000773)1.86488596
169Vertebral arch anomaly (HP:0008438)1.85239783
170Bowing of the arm (HP:0006488)1.84211548
171Bowed forearm bones (HP:0003956)1.84211548
172Venous abnormality (HP:0002624)1.84061626
173* Exostoses (HP:0100777)1.82142190
174Mildly elevated creatine phosphokinase (HP:0008180)1.81932733
175Joint stiffness (HP:0001387)1.81781763
176Femoral bowing (HP:0002980)1.81547748
177Ulnar bowing (HP:0003031)1.81397421
178Nonimmune hydrops fetalis (HP:0001790)1.80156675
179Breech presentation (HP:0001623)1.78141055
180Abnormality of the anterior chamber (HP:0000593)1.78106336
181Gingival overgrowth (HP:0000212)1.78058689
182* Broad long bones (HP:0005622)1.76710175
183* Broad phalanx (HP:0006009)1.72922627
184* Mesomelia (HP:0003027)1.71261473
185Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.69289229
186Abnormality of the frontal sinuses (HP:0002687)1.68881873
187Aplasia/Hypoplasia of the scapulae (HP:0006713)1.68700930
188Hypoplastic scapulae (HP:0000882)1.68700930

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MYLK6.42540374
2MAP3K35.54241659
3STK38L4.51341923
4STK244.13178671
5LIMK13.72415024
6NME13.67059652
7NEK93.58080626
8PDGFRA3.40437829
9PRKG23.29661951
10TESK13.22147729
11PAK22.80192448
12LATS12.60410577
13SIK12.48984009
14PIK3CG2.32973331
15MST42.02442314
16DDR210.0434265
17KIT1.90879843
18STK31.69861751
19PRKD21.68878204
20PLK21.68852414
21TAOK11.68174917
22DMPK1.66621437
23MAPK151.65910841
24ILK1.63511196
25PRKD31.60790253
26ERBB31.60609978
27RIPK11.60258340
28CDC42BPA1.51966488
29NUAK11.51717312
30STK381.50768566
31DAPK31.49684568
32MAPK71.30263441
33MAP3K61.27285073
34LMTK21.23865691
35PTK2B1.18694836
36DYRK1A1.17738937
37EPHA21.16214041
38PAK41.13408377
39PIM21.05627968
40CDK121.03689261
41MAPK121.02703703
42TRIB31.01379377
43GRK51.00711452
44ROCK10.90822904
45MUSK0.89048471
46NEK60.88160792
47EIF2AK30.84052217
48LATS20.82509693
49MKNK20.81855711
50PDK20.81746748
51MET0.80768071
52FRK0.80566343
53CSF1R0.78561942
54PKN20.77825581
55FGFR30.77764423
56CAMKK20.77216765
57RPS6KA20.76823827
58FGFR10.74857796
59PIK3CA0.73217107
60MAP2K30.72759724
61CAMK2G0.69285650
62MAP2K10.69104421
63MAPKAPK30.68006179
64ABL20.67156716
65INSRR0.67064978
66GSK3A0.67012445
67MAP3K70.66191734
68ICK0.65715436
69EIF2AK20.62884074
70MOS0.61821230
71PBK0.61675018
72TRPM70.61591298
73WNK40.61323615
74MINK10.60286822
75TAOK20.58910072
76ADRBK10.57933167
77PKN10.57776279
78CAMK2B0.56753667
79CAMK2D0.55497881
80NME20.52723645
81MAPKAPK50.52591503
82PAK10.52531089
83MARK10.51568623
84EPHB20.50006739
85PNCK0.49705905
86MAPK40.47175382
87PAK60.47156123
88MAP3K110.47097722
89PINK10.46959306
90CAMK10.46926194
91KSR10.46791926
92TGFBR10.45299878
93ERN10.44319011
94PRPF4B0.42146847
95PRKG10.37096050
96PLK30.36824317
97CSNK1A1L0.35760488
98MARK20.35187082
99PRKD10.34573944
100MKNK10.33811633
101PRKCD0.33485655
102MAP3K120.33195657
103SGK10.31930594
104TGFBR20.31701266
105WNK10.31570155
106EPHA40.30465106
107CAMKK10.30320201
108NTRK10.29212694
109PHKG20.28932544
110PHKG10.28932544
111PRKCH0.28655602
112PRKACG0.28407152
113NLK0.27579951
114IGF1R0.27241179
115STK390.27189472
116MAPK100.27095854
117PRKCG0.25470517
118PRKCI0.25171937
119SIK30.24405858
120SRC0.23548979
121PTK20.23238053
122EPHB10.23171603
123JAK30.23125888
124PAK30.23112325
125BRD40.23076786
126STK100.22198608
127CAMK2A0.21066398
128BMX0.20776699
129MAPK10.20273721
130PIM10.20009770
131MTOR0.19146016
132FER0.18577155
133BCR0.18498740
134GRK10.18464781
135RPS6KA60.17662186
136BMPR1B0.17420135
137ABL10.16871936
138RPS6KL10.16537608
139RPS6KC10.16537608
140MAPKAPK20.16447971
141MELK0.16373618
142PDGFRB0.16025399
143RPS6KB10.15786440
144MAPK30.15697458
145TTN0.14595532
146CHUK0.14127488
147MAP3K50.14122865
148ADRBK20.13687935
149ROCK20.13675484
150PRKACA0.13304348
151GRK70.12942662
152PRKCE0.12779144
153INSR0.12631252
154FLT30.11820393

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005327.98543082
2ECM-receptor interaction_Homo sapiens_hsa045126.66094730
3Protein digestion and absorption_Homo sapiens_hsa049746.11900579
4Focal adhesion_Homo sapiens_hsa045102.59181860
5Sulfur metabolism_Homo sapiens_hsa009202.48957570
6Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.38318412
7Vascular smooth muscle contraction_Homo sapiens_hsa042702.09528756
8Malaria_Homo sapiens_hsa051442.01514845
9PI3K-Akt signaling pathway_Homo sapiens_hsa041511.93317192
10Sphingolipid metabolism_Homo sapiens_hsa006001.86733983
11Glycosaminoglycan degradation_Homo sapiens_hsa005311.82053858
12TGF-beta signaling pathway_Homo sapiens_hsa043501.76088683
13Steroid biosynthesis_Homo sapiens_hsa001001.70863569
14Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.69594775
15Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.66373933
16Olfactory transduction_Homo sapiens_hsa047401.53401077
17Dorso-ventral axis formation_Homo sapiens_hsa043201.50951452
18Starch and sucrose metabolism_Homo sapiens_hsa005001.42590676
19Hedgehog signaling pathway_Homo sapiens_hsa043401.42447228
20Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.36985066
21Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.33463627
22Basal cell carcinoma_Homo sapiens_hsa052171.30946032
23Small cell lung cancer_Homo sapiens_hsa052221.30801270
24Pentose and glucuronate interconversions_Homo sapiens_hsa000401.29326863
25Protein export_Homo sapiens_hsa030601.28030316
26Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.23452882
27Proteoglycans in cancer_Homo sapiens_hsa052051.21283220
28Ovarian steroidogenesis_Homo sapiens_hsa049131.20516896
29Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.17176337
30Hippo signaling pathway_Homo sapiens_hsa043901.16713442
31Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.14995838
32Melanoma_Homo sapiens_hsa052181.09622197
33Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.09574583
34Arginine and proline metabolism_Homo sapiens_hsa003301.04679704
35Lysine degradation_Homo sapiens_hsa003101.02630205
36Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.00984196
37Selenocompound metabolism_Homo sapiens_hsa004500.97155540
38Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.92036179
39cGMP-PKG signaling pathway_Homo sapiens_hsa040220.91103914
40Other glycan degradation_Homo sapiens_hsa005110.91082956
41Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.89160224
42Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.82130373
43Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.80167005
44Galactose metabolism_Homo sapiens_hsa000520.78571771
45Tight junction_Homo sapiens_hsa045300.77531924
46Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.75637622
47Long-term depression_Homo sapiens_hsa047300.73154462
48Folate biosynthesis_Homo sapiens_hsa007900.72687572
49Phagosome_Homo sapiens_hsa041450.72507191
50Phospholipase D signaling pathway_Homo sapiens_hsa040720.72150139
51Dilated cardiomyopathy_Homo sapiens_hsa054140.68361531
52Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.68218555
53Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.64778688
54Wnt signaling pathway_Homo sapiens_hsa043100.60598297
55Leukocyte transendothelial migration_Homo sapiens_hsa046700.58962302
56Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.56968166
57N-Glycan biosynthesis_Homo sapiens_hsa005100.56471304
58AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.55880248
59Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.55685493
60Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.54330445
61Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.54144635
62Arachidonic acid metabolism_Homo sapiens_hsa005900.53891978
63Salivary secretion_Homo sapiens_hsa049700.53647526
64Melanogenesis_Homo sapiens_hsa049160.52715140
65Notch signaling pathway_Homo sapiens_hsa043300.52659118
66Bladder cancer_Homo sapiens_hsa052190.52560439
67Thyroid hormone synthesis_Homo sapiens_hsa049180.51681055
68Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.50968823
69Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.50839122
70Adherens junction_Homo sapiens_hsa045200.50158750
71Gastric acid secretion_Homo sapiens_hsa049710.47535668
72Aldosterone synthesis and secretion_Homo sapiens_hsa049250.47397089
73Shigellosis_Homo sapiens_hsa051310.46916439
74Oxytocin signaling pathway_Homo sapiens_hsa049210.46551005
75Calcium signaling pathway_Homo sapiens_hsa040200.44534228
76HIF-1 signaling pathway_Homo sapiens_hsa040660.44513315
77SNARE interactions in vesicular transport_Homo sapiens_hsa041300.43738547
78Renin secretion_Homo sapiens_hsa049240.43233105
79Endocytosis_Homo sapiens_hsa041440.42613450
80Gap junction_Homo sapiens_hsa045400.41749339
81Vibrio cholerae infection_Homo sapiens_hsa051100.41712735
82MicroRNAs in cancer_Homo sapiens_hsa052060.41692414
83Glutamatergic synapse_Homo sapiens_hsa047240.41096393
84Dopaminergic synapse_Homo sapiens_hsa047280.40719268
85GnRH signaling pathway_Homo sapiens_hsa049120.40592402
86Central carbon metabolism in cancer_Homo sapiens_hsa052300.40527930
87One carbon pool by folate_Homo sapiens_hsa006700.39044893
88Thyroid hormone signaling pathway_Homo sapiens_hsa049190.37603379
89Insulin resistance_Homo sapiens_hsa049310.37566177
90TNF signaling pathway_Homo sapiens_hsa046680.37218715
91Circadian entrainment_Homo sapiens_hsa047130.36764143
92Prion diseases_Homo sapiens_hsa050200.36528714
93Thyroid cancer_Homo sapiens_hsa052160.35780714
94Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.34881506
95Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.33922860
96Longevity regulating pathway - mammal_Homo sapiens_hsa042110.33807793
97Regulation of actin cytoskeleton_Homo sapiens_hsa048100.33334840
98Prostate cancer_Homo sapiens_hsa052150.33218713
99Neurotrophin signaling pathway_Homo sapiens_hsa047220.30186975
100cAMP signaling pathway_Homo sapiens_hsa040240.30050434
101Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.29831907
102Axon guidance_Homo sapiens_hsa043600.29407273
103alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.28753068
104Serotonergic synapse_Homo sapiens_hsa047260.28384647
105mTOR signaling pathway_Homo sapiens_hsa041500.28230360
106HTLV-I infection_Homo sapiens_hsa051660.27627159
107Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.27012450
108Complement and coagulation cascades_Homo sapiens_hsa046100.26992806
109Lysosome_Homo sapiens_hsa041420.26862994
110Steroid hormone biosynthesis_Homo sapiens_hsa001400.24825143
111Glucagon signaling pathway_Homo sapiens_hsa049220.24014079
112Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.23908714
113Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.23769422
114Platelet activation_Homo sapiens_hsa046110.23523090
115Rap1 signaling pathway_Homo sapiens_hsa040150.22701236
116Pathways in cancer_Homo sapiens_hsa052000.22617704
117Glutathione metabolism_Homo sapiens_hsa004800.22294114
118Hepatitis B_Homo sapiens_hsa051610.22100833
119Morphine addiction_Homo sapiens_hsa050320.22041482
120Circadian rhythm_Homo sapiens_hsa047100.21922611
121African trypanosomiasis_Homo sapiens_hsa051430.21825440
122Cocaine addiction_Homo sapiens_hsa050300.21315879
123Pancreatic secretion_Homo sapiens_hsa049720.21315696
124Amphetamine addiction_Homo sapiens_hsa050310.20813454
125Renal cell carcinoma_Homo sapiens_hsa052110.20686096
126AMPK signaling pathway_Homo sapiens_hsa041520.19429777
127Cholinergic synapse_Homo sapiens_hsa047250.18809599
128Glioma_Homo sapiens_hsa052140.17677497
129Vitamin digestion and absorption_Homo sapiens_hsa049770.16200519
130ErbB signaling pathway_Homo sapiens_hsa040120.15963653
131Amoebiasis_Homo sapiens_hsa051460.14335191
132MAPK signaling pathway_Homo sapiens_hsa040100.13475594
133Estrogen signaling pathway_Homo sapiens_hsa049150.13012295
134Insulin secretion_Homo sapiens_hsa049110.11512010
135Ras signaling pathway_Homo sapiens_hsa040140.10662962
136Fructose and mannose metabolism_Homo sapiens_hsa000510.10576976

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