ACAP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.83139505
2negative regulation of cell killing (GO:0031342)5.53538503
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.53538503
4regulation of B cell receptor signaling pathway (GO:0050855)5.49210374
5antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.88775962
6axon ensheathment in central nervous system (GO:0032291)4.67238334
7central nervous system myelination (GO:0022010)4.67238334
8regulation of gamma-delta T cell activation (GO:0046643)4.44937972
9regulation of gamma-delta T cell differentiation (GO:0045586)4.39497853
10detection of molecule of bacterial origin (GO:0032490)4.34384471
11cellular extravasation (GO:0045123)4.29140899
12histone H3-K36 demethylation (GO:0070544)4.24176963
13phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)4.12483335
14neutrophil activation involved in immune response (GO:0002283)4.10817328
15antigen processing and presentation of endogenous antigen (GO:0019883)4.02458582
16positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.00185133
17positive regulation of B cell differentiation (GO:0045579)3.97710155
18microglial cell activation (GO:0001774)3.94695096
19positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.93193813
20B cell receptor signaling pathway (GO:0050853)3.92940746
21intracellular lipid transport (GO:0032365)3.90462350
22negative regulation of T cell mediated immunity (GO:0002710)3.88454721
23antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.88369106
24detection of other organism (GO:0098543)3.85609185
25regulation of interleukin-12 biosynthetic process (GO:0045075)3.81661153
26negative regulation of lymphocyte mediated immunity (GO:0002707)3.76705677
27nerve growth factor signaling pathway (GO:0038180)3.70688174
28detection of external biotic stimulus (GO:0098581)3.67805569
29regulation of B cell differentiation (GO:0045577)3.65501225
30nucleoside diphosphate catabolic process (GO:0009134)3.60617969
31neutrophil mediated immunity (GO:0002446)3.59334070
32ensheathment of neurons (GO:0007272)3.58405302
33axon ensheathment (GO:0008366)3.58405302
34myelination (GO:0042552)3.56085068
35antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.54684450
36positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.52576949
37L-amino acid import (GO:0043092)3.52015339
38negative regulation of neurotransmitter secretion (GO:0046929)3.46609771
39regulation of interferon-beta biosynthetic process (GO:0045357)3.43051098
40negative thymic T cell selection (GO:0045060)3.38870774
41response to interleukin-15 (GO:0070672)3.37034260
42negative T cell selection (GO:0043383)3.36884406
43regulation of heat generation (GO:0031650)3.34679003
44regulation of mast cell activation (GO:0033003)3.34386067
45macrophage activation (GO:0042116)3.34021957
46response to peptidoglycan (GO:0032494)3.33564056
47detection of bacterium (GO:0016045)3.31886902
48cytoskeletal anchoring at plasma membrane (GO:0007016)3.27649517
49myeloid cell activation involved in immune response (GO:0002275)3.27435353
50hepatocyte apoptotic process (GO:0097284)3.25523330
51neutrophil activation (GO:0042119)3.24955550
52response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.20860875
53response to host immune response (GO:0052572)3.20860875
54negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)3.18145573
55negative regulation of interleukin-12 production (GO:0032695)3.15677319
56positive regulation of granulocyte differentiation (GO:0030854)3.11423217
57positive regulation of mast cell activation (GO:0033005)3.10732527
58detection of biotic stimulus (GO:0009595)3.10598485
59myeloid leukocyte mediated immunity (GO:0002444)3.08140168
60negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.07214385
61positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.05518448
62negative regulation of leukocyte mediated immunity (GO:0002704)3.05412341
63cortical actin cytoskeleton organization (GO:0030866)3.03796080
64positive thymic T cell selection (GO:0045059)3.03731791
65positive T cell selection (GO:0043368)3.03728417
66nucleus localization (GO:0051647)3.00910371
67cerebral cortex radially oriented cell migration (GO:0021799)2.98705139
68protein targeting to vacuole (GO:0006623)2.97546425
69protein targeting to lysosome (GO:0006622)2.97546425
70establishment of protein localization to vacuole (GO:0072666)2.97546425
71regulation of interleukin-6 biosynthetic process (GO:0045408)2.97174568
72regulation of mast cell activation involved in immune response (GO:0033006)2.97120262
73T-helper 1 type immune response (GO:0042088)2.96233000
74respiratory burst (GO:0045730)2.96162675
75interferon-gamma production (GO:0032609)2.94943534
76regulation of mast cell degranulation (GO:0043304)2.94737487
77production of molecular mediator involved in inflammatory response (GO:0002532)2.94213564
78regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.91089988
79cellular response to interleukin-15 (GO:0071350)2.90720358
80dendritic cell migration (GO:0036336)2.89284119
81negative regulation of adaptive immune response (GO:0002820)2.88168566
82myelin maintenance (GO:0043217)2.87200987
83response to host (GO:0075136)2.86448738
84response to host defenses (GO:0052200)2.86448738
85response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.86448738
86peptidyl-tyrosine autophosphorylation (GO:0038083)2.84957173
87immunoglobulin mediated immune response (GO:0016064)2.84704755
88* protein localization to endosome (GO:0036010)2.82904862
89cellular response to ethanol (GO:0071361)2.81758341
90mast cell activation (GO:0045576)2.80752729
91leukocyte aggregation (GO:0070486)2.80514698
92granulocyte activation (GO:0036230)2.80210666
93leukocyte degranulation (GO:0043299)2.79341752
94positive regulation of toll-like receptor signaling pathway (GO:0034123)2.78855076
95ether lipid metabolic process (GO:0046485)2.78280979
96negative regulation of neurotransmitter transport (GO:0051589)2.77004611
97hypotonic response (GO:0006971)2.76046099
98regulation of alpha-beta T cell proliferation (GO:0046640)2.75360789
99synaptic vesicle maturation (GO:0016188)2.75270533
100positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.74909476
101antigen processing and presentation via MHC class Ib (GO:0002475)2.74044353
102cortical cytoskeleton organization (GO:0030865)2.72648209
103negative regulation of B cell mediated immunity (GO:0002713)2.71612682
104negative regulation of immunoglobulin mediated immune response (GO:0002890)2.71612682
105I-kappaB phosphorylation (GO:0007252)2.70463625
106regulation of NFAT protein import into nucleus (GO:0051532)2.68970534
107locomotory exploration behavior (GO:0035641)2.68969081
108response to lipoprotein particle (GO:0055094)2.68806696
109T cell selection (GO:0045058)2.65827229
110positive regulation of interferon-alpha production (GO:0032727)2.63717425
111import into cell (GO:0098657)2.63184076
112amino acid import (GO:0043090)2.59500704
113adhesion of symbiont to host cell (GO:0044650)2.59167887
114virion attachment to host cell (GO:0019062)2.59167887
115Golgi to endosome transport (GO:0006895)2.59047713
116asymmetric protein localization (GO:0008105)2.58937890
117cellular potassium ion homeostasis (GO:0030007)2.58203143
118regulation of ARF protein signal transduction (GO:0032012)2.55716725
119dendrite morphogenesis (GO:0048813)2.52286513
120ionotropic glutamate receptor signaling pathway (GO:0035235)2.51015025
121regulation of Rap GTPase activity (GO:0032317)2.47076467
122leukocyte migration involved in inflammatory response (GO:0002523)2.45201833
123long-chain fatty acid biosynthetic process (GO:0042759)2.45046015
124stress fiber assembly (GO:0043149)2.43088438
125regulation of short-term neuronal synaptic plasticity (GO:0048172)2.40357919
126apical protein localization (GO:0045176)2.35925090
127positive regulation of Rap GTPase activity (GO:0032854)2.34638908
128astrocyte development (GO:0014002)2.33310247
129negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.33193780
130positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.32897515
131potassium ion import (GO:0010107)2.30927075
132clathrin coat assembly (GO:0048268)2.29435640
133presynaptic membrane organization (GO:0097090)2.28242696
134establishment of nucleus localization (GO:0040023)2.27906235
135platelet-derived growth factor receptor signaling pathway (GO:0048008)2.27379988
136regulation of dendritic spine morphogenesis (GO:0061001)2.27309305
137sodium ion export (GO:0071436)2.24586225
138positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.23988154
139peripheral nervous system axon ensheathment (GO:0032292)2.23322513
140myelination in peripheral nervous system (GO:0022011)2.23322513
141vesicle transport along microtubule (GO:0047496)2.22575172
142adenosine receptor signaling pathway (GO:0001973)2.20895812
143fatty acid elongation (GO:0030497)2.20885314
144dendritic spine morphogenesis (GO:0060997)2.19544508
145* regulation of ARF GTPase activity (GO:0032312)2.19293214
146membrane raft organization (GO:0031579)2.15415475
147oligodendrocyte differentiation (GO:0048709)2.14843861
148glutamate receptor signaling pathway (GO:0007215)2.14324404
149regulation of dendritic spine development (GO:0060998)2.13640803
150negative regulation of protein localization to cell surface (GO:2000009)2.12098671
151* response to nerve growth factor (GO:1990089)2.10870336
152* cellular response to nerve growth factor stimulus (GO:1990090)2.10870336
153lipid translocation (GO:0034204)2.10330247
154phospholipid translocation (GO:0045332)2.10330247
155Rap protein signal transduction (GO:0032486)2.10326642
156transmission of nerve impulse (GO:0019226)2.09289145
157cytoplasmic mRNA processing body assembly (GO:0033962)2.08839630
158neuronal action potential propagation (GO:0019227)2.08760716
159neuromuscular process controlling balance (GO:0050885)2.08358858
160dendritic spine organization (GO:0097061)2.06374727
161adult walking behavior (GO:0007628)2.06371662
162establishment of protein localization to Golgi (GO:0072600)2.06351554
163positive regulation of macrophage cytokine production (GO:0060907)2.05040535
164negative regulation of axonogenesis (GO:0050771)2.04789468
165protein targeting to Golgi (GO:0000042)2.03247463
166regulation of voltage-gated calcium channel activity (GO:1901385)2.03195442
167presynaptic membrane assembly (GO:0097105)2.02680892
168heterotypic cell-cell adhesion (GO:0034113)2.01964575
169modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.00382592
170positive regulation by organism of defense response of other organism involved in symbiotic interact2.00382592
171modulation by symbiont of host immune response (GO:0052553)2.00382592
172positive regulation by symbiont of host defense response (GO:0052509)2.00382592
173modulation by symbiont of host defense response (GO:0052031)2.00382592
174modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.00382592
175negative regulation of exocytosis (GO:0045920)2.00240269
176gamma-aminobutyric acid signaling pathway (GO:0007214)1.99853893
177Rac protein signal transduction (GO:0016601)1.99171116
178regulation of long-term neuronal synaptic plasticity (GO:0048169)1.99141537
179regulation of neuronal synaptic plasticity (GO:0048168)1.98730692
180semaphorin-plexin signaling pathway (GO:0071526)1.98095535
181positive regulation of oligodendrocyte differentiation (GO:0048714)1.97036864
182glycosylceramide metabolic process (GO:0006677)1.96976694
183L-serine transport (GO:0015825)1.96817338
184adhesion of symbiont to host (GO:0044406)1.92727354
185neuronal ion channel clustering (GO:0045161)1.92098670
186glycine transport (GO:0015816)1.92040893
187regulation of beta-amyloid formation (GO:1902003)1.92021967
188macrophage activation involved in immune response (GO:0002281)1.91935331
189layer formation in cerebral cortex (GO:0021819)1.91116711
190glycerophospholipid catabolic process (GO:0046475)1.91053928
191growth hormone receptor signaling pathway (GO:0060396)1.90626907
192synaptic vesicle exocytosis (GO:0016079)1.89976023

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human3.87959405
2RBPJ_22232070_ChIP-Seq_NCS_Mouse2.99542848
3SALL1_21062744_ChIP-ChIP_HESCs_Human2.70266057
4* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.63132291
5VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.48595827
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.46443240
7GBX2_23144817_ChIP-Seq_PC3_Human2.41400673
8POU3F2_20337985_ChIP-ChIP_501MEL_Human2.39448900
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.19220192
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.08209797
11MYB_21317192_ChIP-Seq_ERMYB_Mouse2.07783126
12DROSHA_22980978_ChIP-Seq_HELA_Human2.07609531
13SCL_19346495_ChIP-Seq_HPC-7_Human2.06344584
14EZH2_22144423_ChIP-Seq_EOC_Human2.00338042
15PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.99202369
16MYB_26560356_Chip-Seq_TH2_Human1.96660653
17SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.90188294
18* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.88979756
19CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.88776776
20IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.87124622
21ZNF217_24962896_ChIP-Seq_MCF-7_Human1.81920981
22CDX2_19796622_ChIP-Seq_MESCs_Mouse1.79927485
23SMAD_19615063_ChIP-ChIP_OVARY_Human1.78603579
24SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.75538984
25TP53_16413492_ChIP-PET_HCT116_Human1.74829461
26* SPI1_23547873_ChIP-Seq_NB4_Human1.73889796
27TRIM28_21343339_ChIP-Seq_HEK293_Human1.70815698
28TAF15_26573619_Chip-Seq_HEK293_Human1.68055472
29STAT6_21828071_ChIP-Seq_BEAS2B_Human1.67222651
30EZH2_18974828_ChIP-Seq_MESCs_Mouse1.67071436
31RNF2_18974828_ChIP-Seq_MESCs_Mouse1.67071436
32MTF2_20144788_ChIP-Seq_MESCs_Mouse1.62822109
33SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.62698116
34* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.62599681
35PCGF2_27294783_Chip-Seq_ESCs_Mouse1.61186427
36ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.60725842
37SUZ12_27294783_Chip-Seq_NPCs_Mouse1.58603385
38AR_21572438_ChIP-Seq_LNCaP_Human1.57908985
39JARID2_20064375_ChIP-Seq_MESCs_Mouse1.57236062
40RARB_27405468_Chip-Seq_BRAIN_Mouse1.56647418
41SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.56514021
42PCGF2_27294783_Chip-Seq_NPCs_Mouse1.55016061
43RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.54658352
44CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.54510052
45Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.53527964
46EZH2_27294783_Chip-Seq_NPCs_Mouse1.53250876
47BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.52826322
48* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.47639582
49GATA3_27048872_Chip-Seq_THYMUS_Human1.47456623
50SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.45913583
51SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.45753272
52NFE2_27457419_Chip-Seq_LIVER_Mouse1.45099869
53WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.45014591
54FOXO3_23340844_ChIP-Seq_DLD1_Human1.44207003
55TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.42695460
56* ER_23166858_ChIP-Seq_MCF-7_Human1.41981729
57TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.41572568
58STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.40671201
59MYB_26560356_Chip-Seq_TH1_Human1.39571545
60ZFP57_27257070_Chip-Seq_ESCs_Mouse1.39256643
61SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.37232981
62WT1_19549856_ChIP-ChIP_CCG9911_Human1.36393437
63ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.36140609
64* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.35442313
65* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.35442313
66NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.35330619
67AHR_22903824_ChIP-Seq_MCF-7_Human1.35189899
68WT1_25993318_ChIP-Seq_PODOCYTE_Human1.35170396
69MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.34573304
70NANOG_18555785_Chip-Seq_ESCs_Mouse1.32833671
71IRF8_27001747_Chip-Seq_BMDM_Mouse1.31831927
72RNF2_27304074_Chip-Seq_ESCs_Mouse1.31464979
73* GATA3_26560356_Chip-Seq_TH2_Human1.29734816
74ARNT_22903824_ChIP-Seq_MCF-7_Human1.29263399
75* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29174419
76PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.28068329
77TP53_18474530_ChIP-ChIP_U2OS_Human1.27863294
78JARID2_20075857_ChIP-Seq_MESCs_Mouse1.27261409
79EWS_26573619_Chip-Seq_HEK293_Human1.26608657
80IRF8_21731497_ChIP-ChIP_J774_Mouse1.26423012
81EED_16625203_ChIP-ChIP_MESCs_Mouse1.26070644
82RUNX_20019798_ChIP-Seq_JUKART_Human1.25655233
83PU_27001747_Chip-Seq_BMDM_Mouse1.25544729
84PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.23887056
85* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.23825076
86P53_22387025_ChIP-Seq_ESCs_Mouse1.23096104
87RXR_22108803_ChIP-Seq_LS180_Human1.22652506
88GATA2_21666600_ChIP-Seq_HMVEC_Human1.22471503
89CMYC_18555785_Chip-Seq_ESCs_Mouse1.20723919
90* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.19932441
91AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.19674047
92SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.19416117
93SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.19368025
94SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.19246515
95PIAS1_25552417_ChIP-Seq_VCAP_Human1.17715378
96E2F1_18555785_Chip-Seq_ESCs_Mouse1.16707714
97OCT4_21477851_ChIP-Seq_ESCs_Mouse1.16127968
98EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.15319216
99SUZ12_27294783_Chip-Seq_ESCs_Mouse1.14431359
100* SMAD3_21741376_ChIP-Seq_EPCs_Human1.14334897
101CTNNB1_20460455_ChIP-Seq_HCT116_Human1.14147548
102NOTCH1_21737748_ChIP-Seq_TLL_Human1.13942880
103BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.12538996
104ESR1_20079471_ChIP-ChIP_T-47D_Human1.11445987
105TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.11133928
106SUZ12_18555785_Chip-Seq_ESCs_Mouse1.10207383
107EP300_21415370_ChIP-Seq_HL-1_Mouse1.09707886
108EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.09655827
109IKZF1_21737484_ChIP-ChIP_HCT116_Human1.09385194
110* STAT3_23295773_ChIP-Seq_U87_Human1.09202864
111TP63_17297297_ChIP-ChIP_HaCaT_Human1.08827952
112GATA1_19941826_ChIP-Seq_K562_Human1.08705114
113KDM2B_26808549_Chip-Seq_K562_Human1.08506227
114CRX_20693478_ChIP-Seq_RETINA_Mouse1.08440196
115ESR2_21235772_ChIP-Seq_MCF-7_Human1.08242256
116CTCF_18555785_Chip-Seq_ESCs_Mouse1.07557745
117SMAD4_21799915_ChIP-Seq_A2780_Human1.07407816
118EZH2_27294783_Chip-Seq_ESCs_Mouse1.06477609
119FLI1_21867929_ChIP-Seq_TH2_Mouse1.04938948
120RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04895334
121* CJUN_26792858_Chip-Seq_BT549_Human1.04358288
122SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.03386980
123SOX9_24532713_ChIP-Seq_HFSC_Mouse1.03247544
124VDR_24787735_ChIP-Seq_THP-1_Human1.02739027
125STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.02136119
126RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.02044633
127SPI1_23127762_ChIP-Seq_K562_Human1.01992142
128EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.01958598
129* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.01618480
130KDM2B_26808549_Chip-Seq_SUP-B15_Human1.01227740
131EZH2_27304074_Chip-Seq_ESCs_Mouse1.01138843
132CBP_20019798_ChIP-Seq_JUKART_Human1.00873087
133IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.00873087
134NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.00673440
135STAT3_18555785_Chip-Seq_ESCs_Mouse1.00412813
136SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.99279370
137FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.99147830
138VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.98561847
139GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97709434
140GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97614869
141OCT4_18555785_Chip-Seq_ESCs_Mouse0.97572299
142* PPAR_26484153_Chip-Seq_NCI-H1993_Human0.97221311
143P300_18555785_Chip-Seq_ESCs_Mouse0.97037169
144GATA2_19941826_ChIP-Seq_K562_Human0.96281540
145* NR3C1_23031785_ChIP-Seq_PC12_Mouse0.95870990
146SMRT_27268052_Chip-Seq_Bcells_Human0.95735527
147SOX2_21211035_ChIP-Seq_LN229_Gbm0.95357515
148CTBP1_25329375_ChIP-Seq_LNCAP_Human0.93942752
149* TCF4_23295773_ChIP-Seq_U87_Human0.93199515
150BCAT_22108803_ChIP-Seq_LS180_Human0.93062955
151ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.92639907
152UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.92275693
153EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.91391449
154E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.91341318
155* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.91294233
156GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91224010
157GATA1_22025678_ChIP-Seq_K562_Human0.90712761
158FOXA2_19822575_ChIP-Seq_HepG2_Human0.90525786
159PRDM14_20953172_ChIP-Seq_ESCs_Human0.90402123
160* NR3C1_21868756_ChIP-Seq_MCF10A_Human0.89853945
161TP63_23658742_ChIP-Seq_EP156T_Human0.89515840
162SMAD3_21741376_ChIP-Seq_HESCs_Human0.88999023
163TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.86905774
164YAP1_20516196_ChIP-Seq_MESCs_Mouse0.85466503
165* P300_19829295_ChIP-Seq_ESCs_Human0.85436602
166KDM2B_26808549_Chip-Seq_DND41_Human0.85294626
167AR_19668381_ChIP-Seq_PC3_Human0.84858640

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.43450169
2MP0001835_abnormal_antigen_presentation4.15866639
3MP0003724_increased_susceptibility_to3.95954787
4MP0000920_abnormal_myelination3.63235056
5MP0008438_abnormal_cutaneous_collagen3.61403455
6MP0008260_abnormal_autophagy3.48754844
7MP0003690_abnormal_glial_cell2.93326392
8MP0010234_abnormal_vibrissa_follicle2.72508481
9MP0001800_abnormal_humoral_immune2.63949953
10MP0005671_abnormal_response_to2.57317908
11MP0005171_absent_coat_pigmentation2.55482004
12MP0003436_decreased_susceptibility_to2.53090840
13MP0000569_abnormal_digit_pigmentation2.52529239
14MP0004270_analgesia2.47559720
15MP0003763_abnormal_thymus_physiology2.47534334
16MP0003300_gastrointestinal_ulcer2.45577287
17MP0000685_abnormal_immune_system2.44220882
18MP0003303_peritoneal_inflammation2.35038678
19MP0002009_preneoplasia2.32771477
20MP0002166_altered_tumor_susceptibility2.27440363
21MP0002452_abnormal_antigen_presenting2.27220080
22MP0002723_abnormal_immune_serum2.24025621
23MP0004043_abnormal_pH_regulation2.22807325
24MP0008057_abnormal_DNA_replication2.22056893
25MP0002420_abnormal_adaptive_immunity2.20802321
26MP0001819_abnormal_immune_cell2.18174046
27MP0005025_abnormal_response_to2.11120563
28MP0009785_altered_susceptibility_to2.10776693
29MP0004484_altered_response_of2.09897279
30MP0010678_abnormal_skin_adnexa2.08436651
31MP0005275_abnormal_skin_tensile2.03494655
32MP0003635_abnormal_synaptic_transmissio2.02488741
33MP0005623_abnormal_meninges_morphology1.98785474
34MP0003880_abnormal_central_pattern1.97066111
35MP0003045_fibrosis1.91371647
36MP0000427_abnormal_hair_cycle1.90419733
37MP0005058_abnormal_lysosome_morphology1.89918789
38MP0003329_amyloid_beta_deposits1.88351496
39MP0002398_abnormal_bone_marrow1.87587424
40MP0002064_seizures1.87258911
41MP0002396_abnormal_hematopoietic_system1.86513013
42MP0003091_abnormal_cell_migration1.84879326
43MP0003950_abnormal_plasma_membrane1.83851711
44MP0004885_abnormal_endolymph1.83090398
45MP0003634_abnormal_glial_cell1.82246697
46MP0005464_abnormal_platelet_physiology1.81809849
47MP0006054_spinal_hemorrhage1.78080458
48MP0003172_abnormal_lysosome_physiology1.75504168
49MP0004185_abnormal_adipocyte_glucose1.71399324
50MP0000716_abnormal_immune_system1.71292385
51MP0000689_abnormal_spleen_morphology1.68077679
52MP0002148_abnormal_hypersensitivity_rea1.67618594
53MP0003075_altered_response_to1.65997151
54MP0009745_abnormal_behavioral_response1.65882536
55MP0004883_abnormal_blood_vessel1.63473427
56MP0000604_amyloidosis1.62947446
57MP0000703_abnormal_thymus_morphology1.57271233
58MP0009046_muscle_twitch1.56587802
59MP0004808_abnormal_hematopoietic_stem1.56270600
60MP0002722_abnormal_immune_system1.55235689
61MP0002063_abnormal_learning/memory/cond1.55089812
62MP0001299_abnormal_eye_distance/1.55066271
63MP0002405_respiratory_system_inflammati1.53596848
64MP0001958_emphysema1.52436713
65MP0004381_abnormal_hair_follicle1.49065476
66MP0005310_abnormal_salivary_gland1.49061377
67MP0005075_abnormal_melanosome_morpholog1.47928358
68MP0005174_abnormal_tail_pigmentation1.47903740
69MP0003828_pulmonary_edema1.47389865
70MP0009780_abnormal_chondrocyte_physiolo1.45176310
71MP0002006_tumorigenesis1.42605744
72MP0001486_abnormal_startle_reflex1.42588692
73MP0003633_abnormal_nervous_system1.42418783
74MP0003656_abnormal_erythrocyte_physiolo1.41153600
75MP0003632_abnormal_nervous_system1.40162916
76MP0002272_abnormal_nervous_system1.38649808
77MP0001851_eye_inflammation1.37579047
78MP0001845_abnormal_inflammatory_respons1.35064487
79MP0000383_abnormal_hair_follicle1.34928269
80MP0004272_abnormal_basement_membrane1.33635892
81MP0000015_abnormal_ear_pigmentation1.32618528
82MP0003787_abnormal_imprinting1.31802910
83MP0003191_abnormal_cellular_cholesterol1.31265053
84MP0002429_abnormal_blood_cell1.31187376
85MP0010155_abnormal_intestine_physiology1.30170553
86MP0003631_nervous_system_phenotype1.25988668
87MP0008569_lethality_at_weaning1.25474088
88MP0004510_myositis1.25359017
89MP0003705_abnormal_hypodermis_morpholog1.21994036
90MP0003453_abnormal_keratinocyte_physiol1.20335422
91MP0001177_atelectasis1.18619019
92MP0003183_abnormal_peptide_metabolism1.17532670
93MP0004858_abnormal_nervous_system1.15925481
94MP0005164_abnormal_response_to1.14748823
95MP0003566_abnormal_cell_adhesion1.13643064
96MP0000778_abnormal_nervous_system1.10878508
97MP0009764_decreased_sensitivity_to1.10336618
98MP0002572_abnormal_emotion/affect_behav1.10292809
99MP0003866_abnormal_defecation1.10198173
100MP0001986_abnormal_taste_sensitivity1.07330622
101MP0006082_CNS_inflammation1.06104346
102MP0002090_abnormal_vision1.05720480
103MP0005167_abnormal_blood-brain_barrier1.04980270
104MP0005451_abnormal_body_composition1.04821875
105MP0000613_abnormal_salivary_gland1.04268015
106MP0002998_abnormal_bone_remodeling1.03711970
107MP0002295_abnormal_pulmonary_circulatio1.01529043
108MP0002133_abnormal_respiratory_system1.00297441
109MP0005388_respiratory_system_phenotype1.00297441
110MP0005409_darkened_coat_color0.99352717
111MP0005503_abnormal_tendon_morphology0.99266894
112MP0002095_abnormal_skin_pigmentation0.96823930
113MP0002419_abnormal_innate_immunity0.96746327
114MP0000733_abnormal_muscle_development0.91664972
115MP0001440_abnormal_grooming_behavior0.91446174
116MP0001501_abnormal_sleep_pattern0.90851137
117MP0005397_hematopoietic_system_phenotyp0.90559477
118MP0001545_abnormal_hematopoietic_system0.90559477
119MP0000955_abnormal_spinal_cord0.90224020
120MP0004947_skin_inflammation0.89314685
121MP0001533_abnormal_skeleton_physiology0.87260225
122MP0008469_abnormal_protein_level0.86365028
123MP0004742_abnormal_vestibular_system0.85307117
124MP0000371_diluted_coat_color0.84309721
125MP0000465_gastrointestinal_hemorrhage0.83689606
126MP0000003_abnormal_adipose_tissue0.82393260
127MP0005166_decreased_susceptibility_to0.80723285
128MP0005375_adipose_tissue_phenotype0.80637423
129MP0010352_gastrointestinal_tract_polyps0.79042242
130MP0002060_abnormal_skin_morphology0.78877213
131MP0003795_abnormal_bone_structure0.78691811
132MP0002168_other_aberrant_phenotype0.78267038
133MP0005408_hypopigmentation0.76970997
134MP0001485_abnormal_pinna_reflex0.76946750
135MP0001970_abnormal_pain_threshold0.75847371
136MP0004811_abnormal_neuron_physiology0.75706370
137MP0002933_joint_inflammation0.75190434
138MP0002019_abnormal_tumor_incidence0.75149383
139MP0002229_neurodegeneration0.74212811
140MP0002882_abnormal_neuron_morphology0.73870955
141MP0010307_abnormal_tumor_latency0.73143880
142MP0002734_abnormal_mechanical_nocicepti0.72308134
143MP0009763_increased_sensitivity_to0.72262899
144MP0005076_abnormal_cell_differentiation0.71735924
145MP0000858_altered_metastatic_potential0.71298646
146MP0005387_immune_system_phenotype0.71288103
147MP0001790_abnormal_immune_system0.71288103
148MP0003221_abnormal_cardiomyocyte_apopto0.71084392
149MP0001849_ear_inflammation0.70480201
150MP0003195_calcinosis0.69750809
151MP0005000_abnormal_immune_tolerance0.69616885
152MP0010771_integument_phenotype0.68592423
153MP0009278_abnormal_bone_marrow0.68538718
154MP0002796_impaired_skin_barrier0.68113711
155MP0004134_abnormal_chest_morphology0.67923116
156MP0002693_abnormal_pancreas_physiology0.66961614
157MP0003448_altered_tumor_morphology0.66878688
158MP0001915_intracranial_hemorrhage0.66783673
159MP0002877_abnormal_melanocyte_morpholog0.66471426
160MP0002896_abnormal_bone_mineralization0.65485324
161MP0004130_abnormal_muscle_cell0.64840020
162MP0002066_abnormal_motor_capabilities/c0.64564883
163MP0001873_stomach_inflammation0.64463959
164MP0000462_abnormal_digestive_system0.64410833
165MP0008874_decreased_physiological_sensi0.63682794
166MP0000747_muscle_weakness0.62995600
167MP0002108_abnormal_muscle_morphology0.62851069
168MP0003943_abnormal_hepatobiliary_system0.60474343
169MP0000647_abnormal_sebaceous_gland0.60460104
170MP0001765_abnormal_ion_homeostasis0.60177486
171MP0008877_abnormal_DNA_methylation0.60015518
172MP0003252_abnormal_bile_duct0.57410941
173MP0000249_abnormal_blood_vessel0.56869161
174MP0009765_abnormal_xenobiotic_induced0.56287123

Predicted human phenotypes

RankGene SetZ-score
1Recurrent bacterial skin infections (HP:0005406)4.93684299
2T lymphocytopenia (HP:0005403)4.11212825
3Abnormality of T cell number (HP:0011839)3.88768787
4Neurofibrillary tangles (HP:0002185)3.82215289
5Long nose (HP:0003189)3.70261522
6Recurrent fungal infections (HP:0002841)3.68563650
7Retrobulbar optic neuritis (HP:0100654)3.62894544
8Optic neuritis (HP:0100653)3.62894544
9Myositis (HP:0100614)3.45846928
10Orchitis (HP:0100796)3.41334967
11Chronic mucocutaneous candidiasis (HP:0002728)3.34059776
12Recurrent cutaneous fungal infections (HP:0011370)3.34059776
13Abnormal delayed hypersensitivity skin test (HP:0002963)3.31957112
14Recurrent skin infections (HP:0001581)3.31692907
15Cerebral inclusion bodies (HP:0100314)3.31226311
16Stomatitis (HP:0010280)3.24606448
17Supranuclear gaze palsy (HP:0000605)3.16236561
18Abnormality of macrophages (HP:0004311)3.10921939
19Degeneration of the lateral corticospinal tracts (HP:0002314)3.10326619
20Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.10326619
21Spontaneous hematomas (HP:0007420)3.10093592
22Keratoconjunctivitis sicca (HP:0001097)3.02718946
23Shallow orbits (HP:0000586)2.93515865
24Onion bulb formation (HP:0003383)2.91029242
25Recurrent gram-negative bacterial infections (HP:0005420)2.91012211
26Arterial tortuosity (HP:0005116)2.88725812
27Conical tooth (HP:0000698)2.87161181
28Intention tremor (HP:0002080)2.86763826
29Keratoconjunctivitis (HP:0001096)2.85589599
30Meningitis (HP:0001287)2.84117236
31Mediastinal lymphadenopathy (HP:0100721)2.81522072
32Premature rupture of membranes (HP:0001788)2.81322688
33Broad metatarsal (HP:0001783)2.81289440
34Sensory axonal neuropathy (HP:0003390)2.76120928
35Encephalitis (HP:0002383)2.75293991
36Recurrent viral infections (HP:0004429)2.74744755
37Gastrointestinal infarctions (HP:0005244)2.74214053
38Gingival bleeding (HP:0000225)2.69165854
39Elevated erythrocyte sedimentation rate (HP:0003565)2.65243831
40Increased cerebral lipofuscin (HP:0011813)2.64654725
41Neoplasm of the oral cavity (HP:0100649)2.63492979
42Abnormality of T cells (HP:0002843)2.62779151
43Dysmetria (HP:0001310)2.62762441
44Vascular tortuosity (HP:0004948)2.62056997
45Progressive inability to walk (HP:0002505)2.60688726
46Buphthalmos (HP:0000557)2.57321446
47Arterial thrombosis (HP:0004420)2.56852705
48Panhypogammaglobulinemia (HP:0003139)2.55324748
49Acute lymphatic leukemia (HP:0006721)2.52887579
50Termporal pattern (HP:0011008)2.52195325
51Insidious onset (HP:0003587)2.52195325
52Reduced antithrombin III activity (HP:0001976)2.51715001
53Broad-based gait (HP:0002136)2.50405385
54Aortic dissection (HP:0002647)2.49094097
55Gingivitis (HP:0000230)2.48996361
56Chest pain (HP:0100749)2.48851262
57Subacute progressive viral hepatitis (HP:0006572)2.48529285
58Leukocytosis (HP:0001974)2.47421219
59Cerebral aneurysm (HP:0004944)2.46240417
60Vasculitis (HP:0002633)2.46030462
61Thyroiditis (HP:0100646)2.43511973
62Myokymia (HP:0002411)2.41250567
63Action tremor (HP:0002345)2.39277890
64Abnormality of the pleura (HP:0002103)2.39183934
65Acute myeloid leukemia (HP:0004808)2.38879631
66Viral hepatitis (HP:0006562)2.38747766
67Stomach cancer (HP:0012126)2.37280554
68Abnormality of the corticospinal tract (HP:0002492)2.37113361
69Periodontitis (HP:0000704)2.34024603
70Hemoptysis (HP:0002105)2.33777757
71Hyperventilation (HP:0002883)2.32300573
72Urticaria (HP:0001025)2.29401761
73Hypochromic microcytic anemia (HP:0004840)2.28303331
74Amyotrophic lateral sclerosis (HP:0007354)2.28220568
75Axonal loss (HP:0003447)2.27095565
76Hematochezia (HP:0002573)2.26513662
77Osteolytic defects of the phalanges of the hand (HP:0009771)2.24215354
78Osteolytic defects of the hand bones (HP:0009699)2.24215354
79Aqueductal stenosis (HP:0002410)2.22387422
80Focal motor seizures (HP:0011153)2.22117875
81Abnormality of eosinophils (HP:0001879)2.20902024
82Neuronal loss in central nervous system (HP:0002529)2.20061920
83Focal seizures (HP:0007359)2.19957933
84Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.19506107
85Spastic gait (HP:0002064)2.19465893
86Slow saccadic eye movements (HP:0000514)2.19388721
87Eosinophilia (HP:0001880)2.18894244
88Increased neuronal autofluorescent lipopigment (HP:0002074)2.18635414
89Prolonged bleeding time (HP:0003010)2.18040517
90Turricephaly (HP:0000262)2.17740757
91Abnormality of B cell number (HP:0010975)2.16614596
92Hypoplasia of the iris (HP:0007676)2.16321496
93Epistaxis (HP:0000421)2.15841576
94Obstructive lung disease (HP:0006536)2.15488090
95Chronic obstructive pulmonary disease (HP:0006510)2.15488090
96Absent frontal sinuses (HP:0002688)2.15033352
97Peripheral hypomyelination (HP:0007182)2.14790761
98Scanning speech (HP:0002168)2.14183741
99Recurrent bronchitis (HP:0002837)2.13265916
100Pulmonary infiltrates (HP:0002113)2.12562800
101Osteomyelitis (HP:0002754)2.11688388
102Inflammation of the large intestine (HP:0002037)2.09440732
103Granulocytopenia (HP:0001913)2.07266122
104Interstitial pulmonary disease (HP:0006530)2.06977849
105Autoimmune hemolytic anemia (HP:0001890)2.06577760
106Coronal craniosynostosis (HP:0004440)2.06315233
107Ulnar bowing (HP:0003031)2.06298273
108Abnormality of binocular vision (HP:0011514)2.03343876
109Diplopia (HP:0000651)2.03343876
110Papilledema (HP:0001085)2.02391425
111Mitral valve prolapse (HP:0001634)2.02204969
112Pustule (HP:0200039)2.01040106
113Macroorchidism (HP:0000053)2.00368264
114Heterotopia (HP:0002282)2.00266602
115Thickened helices (HP:0000391)1.99772110
116Lower limb amyotrophy (HP:0007210)1.99061069
117Thick nail (HP:0001805)1.97996168
118Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.97821068
119Oligodontia (HP:0000677)1.97749219
120Aortic aneurysm (HP:0004942)1.97428168
121Aplasia involving bones of the extremities (HP:0009825)1.97391256
122Aplasia involving bones of the upper limbs (HP:0009823)1.97391256
123Aplasia of the phalanges of the hand (HP:0009802)1.97391256
124Spondylolisthesis (HP:0003302)1.96449515
125Colitis (HP:0002583)1.96041975
126Basal cell carcinoma (HP:0002671)1.95067741
127Metaphyseal dysplasia (HP:0100255)1.94980334
128Widely spaced teeth (HP:0000687)1.94160326
129Papillary thyroid carcinoma (HP:0002895)1.94141372
130Cellulitis (HP:0100658)1.94088709
131Megalencephaly (HP:0001355)1.89777371
132Anteriorly placed anus (HP:0001545)1.89713442
133Gastrointestinal inflammation (HP:0004386)1.87381127
134Peritonitis (HP:0002586)1.86737148
135Agammaglobulinemia (HP:0004432)1.85832975
136Neoplasm of the tracheobronchial system (HP:0100552)1.84748491
137Pulmonary embolism (HP:0002204)1.84239733
138Hypoplasia of the thymus (HP:0000778)1.84090834
139Scapular winging (HP:0003691)1.83589493
140Disproportionate tall stature (HP:0001519)1.83320986
141B lymphocytopenia (HP:0010976)1.82914135
142Bulbous nose (HP:0000414)1.82674271
143Severe combined immunodeficiency (HP:0004430)1.81863236
144Lymphopenia (HP:0001888)1.81829354
145Fair hair (HP:0002286)1.81662784
146Atrophic scars (HP:0001075)1.81159754
147Amaurosis fugax (HP:0100576)1.80962134
148Distal lower limb amyotrophy (HP:0008944)1.80686636
149Infantile muscular hypotonia (HP:0008947)1.80327852
150Loss of speech (HP:0002371)1.79725300
151Abnormal platelet volume (HP:0011876)1.79691639
152Deep philtrum (HP:0002002)1.79497364
153Slender build (HP:0001533)1.79344305
154Ankle clonus (HP:0011448)1.78794367
155Recurrent abscess formation (HP:0002722)1.78525706
156Neonatal hypoglycemia (HP:0001998)1.78465001
157Clumsiness (HP:0002312)1.78315100
158Hyporeflexia of lower limbs (HP:0002600)1.77409593
159Abnormal auditory evoked potentials (HP:0006958)1.76818850
160Abnormality of T cell physiology (HP:0011840)1.76465840
161Ankle contracture (HP:0006466)1.75725011
162Protrusio acetabuli (HP:0003179)1.75188165
163Microcytic anemia (HP:0001935)1.75108555
164Hammertoe (HP:0001765)1.75054159
165Premature skin wrinkling (HP:0100678)1.74478228
166Dysostosis multiplex (HP:0000943)1.74025096
167Abnormality of lateral ventricle (HP:0030047)1.73551072
168Arnold-Chiari malformation (HP:0002308)1.73174841
169Hemiplegia (HP:0002301)1.72993916
170Urinary bladder sphincter dysfunction (HP:0002839)1.72865509
171Bronchomalacia (HP:0002780)1.72673150
172Alacrima (HP:0000522)1.71915859
173Abnormality of liposaccharide metabolism (HP:0010968)1.70810463
174Abnormality of glycosphingolipid metabolism (HP:0004343)1.70810463
175Abnormality of glycolipid metabolism (HP:0010969)1.70810463
176Postural instability (HP:0002172)1.70240901
177Increased variability in muscle fiber diameter (HP:0003557)1.69872769
178Large earlobe (HP:0009748)1.69222009
179Wormian bones (HP:0002645)1.68480898
180Bell-shaped thorax (HP:0001591)1.66569367
181Dysdiadochokinesis (HP:0002075)1.64900843
182Atonic seizures (HP:0010819)1.63660960
183Parakeratosis (HP:0001036)1.62706709
184Dilatation of the ascending aorta (HP:0005111)1.62240885
185Gaze-evoked nystagmus (HP:0000640)1.61162631
186Disinhibition (HP:0000734)1.60722111
187Follicular hyperkeratosis (HP:0007502)1.60671804
188Lower limb muscle weakness (HP:0007340)1.59671024
189Decreased motor nerve conduction velocity (HP:0003431)1.59535048
190Eczematoid dermatitis (HP:0000976)1.59067782
191Narrow palate (HP:0000189)1.57575472
192Distal upper limb amyotrophy (HP:0007149)1.56880332

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK33.93826249
2STK393.02833445
3EPHA42.77129660
4EPHB12.65399618
5IRAK42.65092919
6CDC42BPA2.59603432
7BLK2.58930846
8FGFR22.44275069
9TYK22.20210127
10TEC2.07426501
11TXK2.06217379
12MAP3K132.01723541
13MAP4K11.96441100
14RIPK41.95512046
15WNK11.95089545
16CAMK1G1.95016122
17OXSR11.88254275
18MAP3K91.86534071
19FGR1.80941377
20NTRK11.80481852
21IKBKE1.78613609
22BTK1.76003112
23GRK61.74720326
24SGK21.72518436
25CAMK1D1.71847248
26PAK61.69756461
27KIT1.69380934
28KSR21.65796663
29BMPR21.65134636
30MET1.65102745
31PIK3CG1.64258699
32JAK31.62488188
33DMPK1.60259479
34NTRK31.57589144
35MAP2K31.57546330
36SYK1.56670669
37PRPF4B1.52277771
38RIPK11.51146091
39IRAK11.48961150
40TRPM71.46620772
41MAP3K21.41124024
42DDR21.38220435
43FES1.38207367
44BMX1.34767196
45YES11.31123986
46TTN1.27273638
47ZAP701.26951328
48MARK21.24301710
49JAK21.23273780
50PDGFRB1.22147067
51NLK1.21643277
52PRKCH1.21216018
53PKN11.21071109
54LYN1.19425933
55CDK31.15655963
56* LCK1.12939917
57LATS11.09155057
58CSNK1A1L1.07256545
59CAMK2B1.06472170
60TYRO31.06403090
61MAPKAPK51.05568072
62CLK11.02357790
63ROCK21.01496692
64JAK11.01134156
65BCR1.00979831
66TNK21.00215666
67CDK50.99106798
68PDGFRA0.98496909
69CSNK1G20.98460527
70DAPK20.98341331
71RET0.96268989
72EPHA30.93883999
73FYN0.91626466
74CSF1R0.90853969
75CAMKK10.89536993
76CSK0.89355027
77PRKCQ0.88293978
78PDPK10.88224289
79STK380.88071680
80TNIK0.87685352
81SCYL20.87465755
82MAP3K140.85766614
83NEK60.85715771
84RPS6KA40.85701247
85MAP3K70.85544967
86PRKD10.84685965
87PTK60.83399944
88ITK0.80729574
89ICK0.80701463
90MAP3K100.80243517
91PTK2B0.79758607
92STK110.77587463
93TGFBR20.77350078
94PDK10.77292042
95SGK4940.75825807
96SGK2230.75825807
97MOS0.75494289
98STK100.73902232
99MATK0.73766011
100ALK0.73647402
101HIPK20.73539521
102SIK20.73463328
103PAK30.73354437
104* HCK0.73116804
105IKBKB0.71551535
106PTK20.70579464
107ACVR1B0.69808087
108MARK30.69212420
109IRAK20.68956446
110FER0.68766345
111FGFR10.68366302
112NEK90.68326100
113PLK20.68257829
114CAMK2D0.65274898
115BRSK20.63357736
116INSR0.62713972
117SGK10.62275378
118FGFR30.61585938
119TBK10.61201344
120MELK0.59793255
121STK40.59382540
122PRKD30.59224625
123FLT30.58726420
124NTRK20.56458114
125MAP3K30.56257786
126PAK20.54522854
127WNK40.54413970
128PRKD20.53354469
129PRKCE0.53333391
130PBK0.53187205
131UHMK10.51342721
132ADRBK10.50795005
133SRC0.49906295
134FRK0.49199339
135STK30.48796870
136SGK30.46662813
137EIF2AK30.46540027
138CAMK2A0.46241353
139MAPK100.46139809
140CAMKK20.45572090
141EGFR0.45116672
142BRD40.44953115
143CAMK40.44650025
144NUAK10.44418762
145CSNK1G30.44299791
146CDK140.44171117
147AKT30.43928968
148KSR10.43814393
149SIK10.43485689
150MAP3K60.43245541
151MAP3K10.43065921
152PIM10.42509617
153PRKAA20.40656569
154GRK50.40276813
155DYRK30.35075060
156* ABL10.32111356

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053322.00958895
2Allograft rejection_Homo sapiens_hsa053301.97713592
3Staphylococcus aureus infection_Homo sapiens_hsa051501.89121155
4Regulation of autophagy_Homo sapiens_hsa041401.84961558
5Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.82675308
6Autoimmune thyroid disease_Homo sapiens_hsa053201.81849584
7Type I diabetes mellitus_Homo sapiens_hsa049401.71874471
8Measles_Homo sapiens_hsa051621.67641764
9NOD-like receptor signaling pathway_Homo sapiens_hsa046211.65165333
10Asthma_Homo sapiens_hsa053101.60849676
11Glutamatergic synapse_Homo sapiens_hsa047241.57093601
12Jak-STAT signaling pathway_Homo sapiens_hsa046301.53000092
13Primary immunodeficiency_Homo sapiens_hsa053401.51937741
14Nitrogen metabolism_Homo sapiens_hsa009101.51634004
15Long-term potentiation_Homo sapiens_hsa047201.50908828
16Circadian entrainment_Homo sapiens_hsa047131.50577039
17Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.50030518
18Salivary secretion_Homo sapiens_hsa049701.48652415
19NF-kappa B signaling pathway_Homo sapiens_hsa040641.47588863
20Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.47254431
21Intestinal immune network for IgA production_Homo sapiens_hsa046721.46839476
22Prolactin signaling pathway_Homo sapiens_hsa049171.46616005
23Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.42020103
24Hematopoietic cell lineage_Homo sapiens_hsa046401.37749598
25Morphine addiction_Homo sapiens_hsa050321.37403152
26Long-term depression_Homo sapiens_hsa047301.34616565
27Axon guidance_Homo sapiens_hsa043601.28912352
28Dorso-ventral axis formation_Homo sapiens_hsa043201.28133795
29Antigen processing and presentation_Homo sapiens_hsa046121.27752042
30Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.27392717
31Influenza A_Homo sapiens_hsa051641.26728477
32Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.26424473
33Viral myocarditis_Homo sapiens_hsa054161.24696223
34GABAergic synapse_Homo sapiens_hsa047271.24395392
35Gastric acid secretion_Homo sapiens_hsa049711.24277672
36Renin secretion_Homo sapiens_hsa049241.23111907
37Phospholipase D signaling pathway_Homo sapiens_hsa040721.21533570
38Renal cell carcinoma_Homo sapiens_hsa052111.18643771
39Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.17800591
40Phosphatidylinositol signaling system_Homo sapiens_hsa040701.17761833
41Osteoclast differentiation_Homo sapiens_hsa043801.17106888
42Olfactory transduction_Homo sapiens_hsa047401.16578234
43Acute myeloid leukemia_Homo sapiens_hsa052211.15725250
44Cholinergic synapse_Homo sapiens_hsa047251.13543600
45RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.12763241
46Sphingolipid signaling pathway_Homo sapiens_hsa040711.12677770
47Glioma_Homo sapiens_hsa052141.12257297
48Type II diabetes mellitus_Homo sapiens_hsa049301.11219746
49B cell receptor signaling pathway_Homo sapiens_hsa046621.10853624
50Legionellosis_Homo sapiens_hsa051341.10475933
51Dopaminergic synapse_Homo sapiens_hsa047281.09773407
52* Endocytosis_Homo sapiens_hsa041441.09222373
53Oxytocin signaling pathway_Homo sapiens_hsa049211.08251258
54Lysosome_Homo sapiens_hsa041421.07470251
55Leukocyte transendothelial migration_Homo sapiens_hsa046701.06336580
56mTOR signaling pathway_Homo sapiens_hsa041501.05286428
57GnRH signaling pathway_Homo sapiens_hsa049121.05211917
58Nicotine addiction_Homo sapiens_hsa050331.05199867
59Hepatitis B_Homo sapiens_hsa051611.05162477
60ECM-receptor interaction_Homo sapiens_hsa045121.04988093
61Regulation of actin cytoskeleton_Homo sapiens_hsa048101.04977151
62Amphetamine addiction_Homo sapiens_hsa050311.04616685
63Chemokine signaling pathway_Homo sapiens_hsa040621.03562194
64Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.03113938
65Focal adhesion_Homo sapiens_hsa045101.02885834
66Platelet activation_Homo sapiens_hsa046111.02402925
67ErbB signaling pathway_Homo sapiens_hsa040121.02124737
68Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.01258863
69cAMP signaling pathway_Homo sapiens_hsa040241.00994394
70Aldosterone synthesis and secretion_Homo sapiens_hsa049251.00780331
71Herpes simplex infection_Homo sapiens_hsa051681.00061066
72Proteoglycans in cancer_Homo sapiens_hsa052050.96066158
73Rap1 signaling pathway_Homo sapiens_hsa040150.94314488
74Estrogen signaling pathway_Homo sapiens_hsa049150.94086874
75Choline metabolism in cancer_Homo sapiens_hsa052310.93701487
76Amoebiasis_Homo sapiens_hsa051460.93619684
77VEGF signaling pathway_Homo sapiens_hsa043700.92848160
78Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.92684225
79Serotonergic synapse_Homo sapiens_hsa047260.92601911
80Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.92378037
81Cocaine addiction_Homo sapiens_hsa050300.91321112
82Vascular smooth muscle contraction_Homo sapiens_hsa042700.91072361
83Synaptic vesicle cycle_Homo sapiens_hsa047210.90789241
84Salmonella infection_Homo sapiens_hsa051320.89241043
85Colorectal cancer_Homo sapiens_hsa052100.88825538
86Malaria_Homo sapiens_hsa051440.88746828
87Leishmaniasis_Homo sapiens_hsa051400.86931836
88Ether lipid metabolism_Homo sapiens_hsa005650.86310417
89Ras signaling pathway_Homo sapiens_hsa040140.85266330
90Hepatitis C_Homo sapiens_hsa051600.82710286
91cGMP-PKG signaling pathway_Homo sapiens_hsa040220.82446737
92FoxO signaling pathway_Homo sapiens_hsa040680.81846501
93Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.81421200
94Tuberculosis_Homo sapiens_hsa051520.81277124
95MAPK signaling pathway_Homo sapiens_hsa040100.81131995
96Gap junction_Homo sapiens_hsa045400.80981893
97TNF signaling pathway_Homo sapiens_hsa046680.80643716
98Pancreatic cancer_Homo sapiens_hsa052120.80045116
99Pancreatic secretion_Homo sapiens_hsa049720.79571162
100Endometrial cancer_Homo sapiens_hsa052130.79109915
101Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.78096077
102Neurotrophin signaling pathway_Homo sapiens_hsa047220.77808066
103Adherens junction_Homo sapiens_hsa045200.77751955
104Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.77127613
105Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.75849747
106Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.75401397
107Inositol phosphate metabolism_Homo sapiens_hsa005620.75383166
108Chronic myeloid leukemia_Homo sapiens_hsa052200.74349266
109AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.74002254
110Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.73808698
111Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.73547555
112Sphingolipid metabolism_Homo sapiens_hsa006000.72815723
113T cell receptor signaling pathway_Homo sapiens_hsa046600.72340886
114Insulin secretion_Homo sapiens_hsa049110.72277524
115Calcium signaling pathway_Homo sapiens_hsa040200.71692551
116Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.69717938
117Non-small cell lung cancer_Homo sapiens_hsa052230.69646454
118ABC transporters_Homo sapiens_hsa020100.68438363
119Dilated cardiomyopathy_Homo sapiens_hsa054140.68147402
120Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.67787726
121Non-homologous end-joining_Homo sapiens_hsa034500.67352312
122Pertussis_Homo sapiens_hsa051330.65773730
123Phagosome_Homo sapiens_hsa041450.65540465
124Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.65270132
125Toxoplasmosis_Homo sapiens_hsa051450.64872618
126Rheumatoid arthritis_Homo sapiens_hsa053230.64836231
127Tight junction_Homo sapiens_hsa045300.64830871
128Thyroid hormone synthesis_Homo sapiens_hsa049180.64513197
129Steroid biosynthesis_Homo sapiens_hsa001000.64483548
130Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.63453492
131Carbohydrate digestion and absorption_Homo sapiens_hsa049730.63153522
132African trypanosomiasis_Homo sapiens_hsa051430.62944100
133Melanogenesis_Homo sapiens_hsa049160.62553422
134Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.62416952
135Shigellosis_Homo sapiens_hsa051310.62080790
136Transcriptional misregulation in cancer_Homo sapiens_hsa052020.61996780
137Other glycan degradation_Homo sapiens_hsa005110.61824998
138Toll-like receptor signaling pathway_Homo sapiens_hsa046200.61436889
139MicroRNAs in cancer_Homo sapiens_hsa052060.60044925
140Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.59482791
141Prostate cancer_Homo sapiens_hsa052150.56636847
142SNARE interactions in vesicular transport_Homo sapiens_hsa041300.55858631
143Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.52897178
144Apoptosis_Homo sapiens_hsa042100.52539454
145Viral carcinogenesis_Homo sapiens_hsa052030.50731824
146Insulin resistance_Homo sapiens_hsa049310.49703538
147Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.48991765
148Taste transduction_Homo sapiens_hsa047420.45533978
149Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.45003628
150HTLV-I infection_Homo sapiens_hsa051660.42883297
151Thyroid cancer_Homo sapiens_hsa052160.39783034
152Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.39732973

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