

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | synaptic vesicle maturation (GO:0016188) | 5.92220300 |
| 2 | locomotory exploration behavior (GO:0035641) | 5.66387999 |
| 3 | regulation of short-term neuronal synaptic plasticity (GO:0048172) | 5.63741376 |
| 4 | positive regulation of calcium ion-dependent exocytosis (GO:0045956) | 5.32215019 |
| 5 | positive regulation of excitatory postsynaptic membrane potential (GO:2000463) | 5.31973422 |
| 6 | vocalization behavior (GO:0071625) | 5.15008980 |
| 7 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act | 5.09829358 |
| 8 | synaptic vesicle exocytosis (GO:0016079) | 5.09430783 |
| 9 | layer formation in cerebral cortex (GO:0021819) | 4.87476296 |
| 10 | synaptic vesicle docking involved in exocytosis (GO:0016081) | 4.80656630 |
| 11 | glutamate secretion (GO:0014047) | 4.69252686 |
| 12 | regulation of synaptic vesicle exocytosis (GO:2000300) | 4.62257793 |
| 13 | regulation of glutamate receptor signaling pathway (GO:1900449) | 4.59104023 |
| 14 | regulation of synapse structural plasticity (GO:0051823) | 4.58921495 |
| 15 | protein localization to synapse (GO:0035418) | 4.55468953 |
| 16 | exploration behavior (GO:0035640) | 4.41575737 |
| 17 | neuron cell-cell adhesion (GO:0007158) | 4.36980022 |
| 18 | dendritic spine morphogenesis (GO:0060997) | 4.35611698 |
| 19 | regulation of neuronal synaptic plasticity (GO:0048168) | 4.29660519 |
| 20 | regulation of long-term neuronal synaptic plasticity (GO:0048169) | 4.22071422 |
| 21 | ionotropic glutamate receptor signaling pathway (GO:0035235) | 4.16506826 |
| 22 | neuronal action potential propagation (GO:0019227) | 4.04088414 |
| 23 | regulation of synaptic vesicle transport (GO:1902803) | 4.01753694 |
| 24 | neurotransmitter secretion (GO:0007269) | 3.99564144 |
| 25 | positive regulation of synapse maturation (GO:0090129) | 3.93174135 |
| 26 | neuronal ion channel clustering (GO:0045161) | 3.91891557 |
| 27 | dendrite morphogenesis (GO:0048813) | 3.80950666 |
| 28 | long-term memory (GO:0007616) | 3.79802303 |
| 29 | synaptic transmission, glutamatergic (GO:0035249) | 3.72789129 |
| 30 | positive regulation of synaptic transmission, GABAergic (GO:0032230) | 3.71455464 |
| 31 | proline transport (GO:0015824) | 3.70366862 |
| 32 | regulation of dendritic spine morphogenesis (GO:0061001) | 3.68422608 |
| 33 | glutamate receptor signaling pathway (GO:0007215) | 3.68343143 |
| 34 | sodium ion export (GO:0071436) | 3.67429756 |
| 35 | neurotransmitter-gated ion channel clustering (GO:0072578) | 3.66366568 |
| 36 | regulation of ARF protein signal transduction (GO:0032012) | 3.65049449 |
| 37 | L-amino acid import (GO:0043092) | 3.59837239 |
| 38 | activation of protein kinase A activity (GO:0034199) | 3.58641210 |
| 39 | cell migration in hindbrain (GO:0021535) | 3.56829969 |
| 40 | neuron recognition (GO:0008038) | 3.55369076 |
| 41 | semaphorin-plexin signaling pathway (GO:0071526) | 3.53405928 |
| 42 | neuromuscular process controlling balance (GO:0050885) | 3.52805033 |
| 43 | regulation of excitatory postsynaptic membrane potential (GO:0060079) | 3.47422930 |
| 44 | amino acid import (GO:0043090) | 3.46996761 |
| 45 | axonal fasciculation (GO:0007413) | 3.46857252 |
| 46 | membrane depolarization during cardiac muscle cell action potential (GO:0086012) | 3.42743337 |
| 47 | positive regulation of synaptic transmission, glutamatergic (GO:0051968) | 3.42044260 |
| 48 | cellular potassium ion homeostasis (GO:0030007) | 3.41675329 |
| 49 | positive regulation of membrane potential (GO:0045838) | 3.41392344 |
| 50 | neuron-neuron synaptic transmission (GO:0007270) | 3.40883836 |
| 51 | gamma-aminobutyric acid transport (GO:0015812) | 3.40088485 |
| 52 | synaptic vesicle endocytosis (GO:0048488) | 3.38746915 |
| 53 | regulation of postsynaptic membrane potential (GO:0060078) | 3.34697354 |
| 54 | G-protein coupled acetylcholine receptor signaling pathway (GO:0007213) | 3.33616160 |
| 55 | regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310) | 3.32987171 |
| 56 | innervation (GO:0060384) | 3.32627173 |
| 57 | regulation of synaptic plasticity (GO:0048167) | 3.32430487 |
| 58 | auditory behavior (GO:0031223) | 3.27015310 |
| 59 | postsynaptic membrane organization (GO:0001941) | 3.22668424 |
| 60 | axon ensheathment in central nervous system (GO:0032291) | 3.22521935 |
| 61 | central nervous system myelination (GO:0022010) | 3.22521935 |
| 62 | cell communication by electrical coupling (GO:0010644) | 3.21501263 |
| 63 | cerebellar Purkinje cell differentiation (GO:0021702) | 3.20812187 |
| 64 | positive regulation of dendritic spine development (GO:0060999) | 3.17097322 |
| 65 | negative regulation of microtubule polymerization (GO:0031115) | 3.14649509 |
| 66 | regulation of inhibitory postsynaptic membrane potential (GO:0060080) | 3.14157387 |
| 67 | positive regulation of dendritic spine morphogenesis (GO:0061003) | 3.13392725 |
| 68 | prepulse inhibition (GO:0060134) | 3.12679553 |
| 69 | regulation of neurotransmitter secretion (GO:0046928) | 3.11900329 |
| 70 | positive regulation of neurotransmitter secretion (GO:0001956) | 3.11043029 |
| 71 | regulation of dendritic spine development (GO:0060998) | 3.10576091 |
| 72 | cell communication by electrical coupling involved in cardiac conduction (GO:0086064) | 3.09699830 |
| 73 | regulation of synaptic transmission, glutamatergic (GO:0051966) | 3.05831497 |
| 74 | neurotransmitter transport (GO:0006836) | 3.05669412 |
| 75 | negative regulation of erythrocyte differentiation (GO:0045647) | 3.05134524 |
| 76 | peptidyl-tyrosine autophosphorylation (GO:0038083) | 3.02482055 |
| 77 | mannose metabolic process (GO:0006013) | 3.01634978 |
| 78 | potassium ion homeostasis (GO:0055075) | 3.01539301 |
| 79 | regulation of vesicle fusion (GO:0031338) | 3.01176754 |
| 80 | dendritic spine organization (GO:0097061) | 3.01022013 |
| 81 | transmission of nerve impulse (GO:0019226) | 2.99679213 |
| 82 | cell-cell junction maintenance (GO:0045217) | 2.98126689 |
| 83 | establishment of mitochondrion localization (GO:0051654) | 2.98080005 |
| 84 | positive regulation of synaptic transmission, dopaminergic (GO:0032226) | 2.96064469 |
| 85 | glycine transport (GO:0015816) | 2.94288381 |
| 86 | * regulation of ARF GTPase activity (GO:0032312) | 2.93274238 |
| 87 | positive regulation of neurotransmitter transport (GO:0051590) | 2.93147557 |
| 88 | vesicle transport along microtubule (GO:0047496) | 2.92957396 |
| 89 | membrane depolarization during action potential (GO:0086010) | 2.92732878 |
| 90 | mitochondrion transport along microtubule (GO:0047497) | 2.91625110 |
| 91 | establishment of mitochondrion localization, microtubule-mediated (GO:0034643) | 2.91625110 |
| 92 | negative regulation of amyloid precursor protein catabolic process (GO:1902992) | 2.91288850 |
| 93 | cerebellar Purkinje cell layer development (GO:0021680) | 2.91140204 |
| 94 | cytoskeletal anchoring at plasma membrane (GO:0007016) | 2.90436609 |
| 95 | membrane depolarization (GO:0051899) | 2.88662182 |
| 96 | positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr | 2.88416740 |
| 97 | long-term synaptic potentiation (GO:0060291) | 2.88227137 |
| 98 | regulation of neurotransmitter transport (GO:0051588) | 2.87370151 |
| 99 | organelle transport along microtubule (GO:0072384) | 2.87170683 |
| 100 | response to auditory stimulus (GO:0010996) | 2.86205197 |
| 101 | learning (GO:0007612) | 2.85874503 |
| 102 | regulation of synapse maturation (GO:0090128) | 2.85783328 |
| 103 | axon cargo transport (GO:0008088) | 2.85671084 |
| 104 | central nervous system projection neuron axonogenesis (GO:0021952) | 2.85617778 |
| 105 | regulation of neurotransmitter levels (GO:0001505) | 2.84678728 |
| 106 | synapse assembly (GO:0007416) | 2.83012653 |
| 107 | regulation of respiratory gaseous exchange by neurological system process (GO:0002087) | 2.82184054 |
| 108 | clathrin coat assembly (GO:0048268) | 2.81967339 |
| 109 | cerebellar granule cell differentiation (GO:0021707) | 2.80462487 |
| 110 | establishment of nucleus localization (GO:0040023) | 2.78965261 |
| 111 | positive regulation of synaptic transmission (GO:0050806) | 2.78132358 |
| 112 | positive regulation of potassium ion transmembrane transporter activity (GO:1901018) | 2.77910894 |
| 113 | intraspecies interaction between organisms (GO:0051703) | 2.77420604 |
| 114 | social behavior (GO:0035176) | 2.77420604 |
| 115 | regulation of synaptic transmission (GO:0050804) | 2.77190067 |
| 116 | neuromuscular process (GO:0050905) | 2.75526388 |
| 117 | gamma-aminobutyric acid signaling pathway (GO:0007214) | 2.75436931 |
| 118 | dopamine receptor signaling pathway (GO:0007212) | 2.62333530 |
| 119 | potassium ion import (GO:0010107) | 2.62304165 |
| 120 | cellular sodium ion homeostasis (GO:0006883) | 2.58034475 |
| 121 | negative regulation of cell size (GO:0045792) | 2.54042436 |
| 122 | cell differentiation in hindbrain (GO:0021533) | 2.53166469 |
| 123 | positive regulation of dendrite development (GO:1900006) | 2.53126663 |
| 124 | mating behavior (GO:0007617) | 2.50655916 |
| 125 | neuromuscular process controlling posture (GO:0050884) | 2.48174473 |
| 126 | signal complex assembly (GO:0007172) | 2.47346168 |
| 127 | cellular response to monoamine stimulus (GO:0071868) | 2.44827114 |
| 128 | cellular response to catecholamine stimulus (GO:0071870) | 2.44827114 |
| 129 | protein targeting to plasma membrane (GO:0072661) | 2.44776738 |
| 130 | chondroitin sulfate catabolic process (GO:0030207) | 2.44448884 |
| 131 | activation of Rac GTPase activity (GO:0032863) | 2.37191747 |
| 132 | cell volume homeostasis (GO:0006884) | 2.36646391 |
| 133 | positive regulation of protein dephosphorylation (GO:0035307) | 2.36539588 |
| 134 | myelin maintenance (GO:0043217) | 2.34554274 |
| 135 | negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067) | 2.34240019 |
| 136 | adherens junction assembly (GO:0034333) | 2.33366712 |
| 137 | protein retention in ER lumen (GO:0006621) | 2.32017018 |
| 138 | negative regulation of dendrite morphogenesis (GO:0050774) | 2.30948534 |
| 139 | cell junction maintenance (GO:0034331) | 2.30138656 |
| 140 | regulation of dendrite morphogenesis (GO:0048814) | 2.29137080 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EZH2_22144423_ChIP-Seq_EOC_Human | 5.81885749 |
| 2 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 3.08073379 |
| 3 | SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 3.04631783 |
| 4 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 2.96552871 |
| 5 | RARB_27405468_Chip-Seq_BRAIN_Mouse | 2.83006519 |
| 6 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 2.82794334 |
| 7 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 2.82794334 |
| 8 | DROSHA_22980978_ChIP-Seq_HELA_Human | 2.74667901 |
| 9 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 2.72614170 |
| 10 | * REST_21632747_ChIP-Seq_MESCs_Mouse | 2.60452392 |
| 11 | SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 2.59607692 |
| 12 | EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 2.56677406 |
| 13 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 2.55315293 |
| 14 | MTF2_20144788_ChIP-Seq_MESCs_Mouse | 2.54169896 |
| 15 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 2.50888213 |
| 16 | AR_21572438_ChIP-Seq_LNCaP_Human | 2.50646915 |
| 17 | GBX2_23144817_ChIP-Seq_PC3_Human | 2.50384172 |
| 18 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 2.50355303 |
| 19 | SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 2.49339530 |
| 20 | EZH2_27294783_Chip-Seq_ESCs_Mouse | 2.48267736 |
| 21 | SUZ12_27294783_Chip-Seq_ESCs_Mouse | 2.46318390 |
| 22 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 2.34041892 |
| 23 | RNF2_27304074_Chip-Seq_ESCs_Mouse | 2.27427698 |
| 24 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 2.26304505 |
| 25 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 2.17891758 |
| 26 | REST_18959480_ChIP-ChIP_MESCs_Mouse | 2.17849520 |
| 27 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 2.15439041 |
| 28 | * KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 2.07233045 |
| 29 | TP63_17297297_ChIP-ChIP_HaCaT_Human | 2.03665653 |
| 30 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 2.00750542 |
| 31 | * ELK3_25401928_ChIP-Seq_HUVEC_Human | 1.86886028 |
| 32 | VDR_21846776_ChIP-Seq_THP-1_Human | 1.84845672 |
| 33 | ESR2_21235772_ChIP-Seq_MCF-7_Human | 1.84714762 |
| 34 | * TCF7_22412390_ChIP-Seq_EML_Mouse | 1.83655019 |
| 35 | RACK7_27058665_Chip-Seq_MCF-7_Human | 1.82527320 |
| 36 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 1.81668811 |
| 37 | ZFP281_18757296_ChIP-ChIP_E14_Mouse | 1.77393118 |
| 38 | * KDM2B_26808549_Chip-Seq_K562_Human | 1.76578704 |
| 39 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 1.75828920 |
| 40 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 1.74086480 |
| 41 | SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 1.67804593 |
| 42 | WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse | 1.67473891 |
| 43 | DNAJC2_21179169_ChIP-ChIP_NT2_Human | 1.64441727 |
| 44 | * P68_20966046_ChIP-Seq_HELA_Human | 1.60403212 |
| 45 | * UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human | 1.58538874 |
| 46 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.55651144 |
| 47 | RING1B_27294783_Chip-Seq_ESCs_Mouse | 1.54406356 |
| 48 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 1.52535017 |
| 49 | EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human | 1.47861299 |
| 50 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 1.45673717 |
| 51 | ZFP281_27345836_Chip-Seq_ESCs_Mouse | 1.43747929 |
| 52 | * CTCF_27219007_Chip-Seq_ERYTHROID_Human | 1.43653795 |
| 53 | TET1_21451524_ChIP-Seq_MESCs_Mouse | 1.42597111 |
| 54 | TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 1.41341116 |
| 55 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 1.41131524 |
| 56 | * SA1_27219007_Chip-Seq_ERYTHROID_Human | 1.40835694 |
| 57 | RING1B_27294783_Chip-Seq_NPCs_Mouse | 1.40054667 |
| 58 | SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 1.39443596 |
| 59 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.36321172 |
| 60 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 1.36270664 |
| 61 | WT1_25993318_ChIP-Seq_PODOCYTE_Human | 1.36248455 |
| 62 | RCOR3_21632747_ChIP-Seq_MESCs_Mouse | 1.35679668 |
| 63 | * KDM2B_26808549_Chip-Seq_HPB-ALL_Human | 1.34323002 |
| 64 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.33504092 |
| 65 | MYC_22102868_ChIP-Seq_BL_Human | 1.33456965 |
| 66 | * CREB1_26743006_Chip-Seq_LNCaP-abl_Human | 1.29555115 |
| 67 | RNF2_16625203_ChIP-ChIP_MESCs_Mouse | 1.29448561 |
| 68 | GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.27844669 |
| 69 | TCF3_18467660_ChIP-ChIP_MESCs_Mouse | 1.25910640 |
| 70 | NR3C1_23031785_ChIP-Seq_PC12_Mouse | 1.25692307 |
| 71 | EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse | 1.22885494 |
| 72 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 1.22252411 |
| 73 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.20900916 |
| 74 | * P300_27058665_Chip-Seq_ZR-75-30cells_Human | 1.19605333 |
| 75 | RUNX2_24764292_ChIP-Seq_MC3T3_Mouse | 1.17351855 |
| 76 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 1.16888503 |
| 77 | SOX2_21211035_ChIP-Seq_LN229_Gbm | 1.16529708 |
| 78 | * MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human | 1.16479752 |
| 79 | AR_19668381_ChIP-Seq_PC3_Human | 1.14695887 |
| 80 | * KDM2B_26808549_Chip-Seq_DND41_Human | 1.14236705 |
| 81 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 1.14180677 |
| 82 | TRIM28_21343339_ChIP-Seq_HEK293_Human | 1.12621328 |
| 83 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.11821482 |
| 84 | SMAD4_21799915_ChIP-Seq_A2780_Human | 1.11771453 |
| 85 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.11660426 |
| 86 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 1.11267537 |
| 87 | * DMRT1_23473982_ChIP-Seq_TESTES_Mouse | 1.11028910 |
| 88 | LXR_22292898_ChIP-Seq_THP-1_Human | 1.10770225 |
| 89 | OLIG2_26023283_ChIP-Seq_AINV15_Mouse | 1.10225586 |
| 90 | * CTCF_27219007_Chip-Seq_Bcells_Human | 1.08033552 |
| 91 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 1.07505837 |
| 92 | KDM2B_26808549_Chip-Seq_JURKAT_Human | 1.06490553 |
| 93 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.05886169 |
| 94 | TP53_23651856_ChIP-Seq_MEFs_Mouse | 1.05634399 |
| 95 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.05566665 |
| 96 | * TET1_21490601_ChIP-Seq_MESCs_Mouse | 1.04138786 |
| 97 | TP53_22127205_ChIP-Seq_IMR90_Human | 1.03047272 |
| 98 | ELF1_20517297_ChIP-Seq_JURKAT_Human | 1.02589144 |
| 99 | RCOR2_21632747_ChIP-Seq_MESCs_Mouse | 1.02523426 |
| 100 | GATA1_19941827_ChIP-Seq_MEL_Mouse | 1.01929801 |
| 101 | RUNX1_27514584_Chip-Seq_MCF-7_Human | 1.01601218 |
| 102 | PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse | 1.01387891 |
| 103 | TP63_22573176_ChIP-Seq_HFKS_Human | 1.00221822 |
| 104 | MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse | 0.99563432 |
| 105 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 0.99298867 |
| 106 | P53_22127205_ChIP-Seq_FIBROBLAST_Human | 0.98405835 |
| 107 | NFIB_24661679_ChIP-Seq_LUNG_Mouse | 0.98161889 |
| 108 | SMAD3_22036565_ChIP-Seq_ESCs_Mouse | 0.97412011 |
| 109 | SMAD2/3_21741376_ChIP-Seq_ESCs_Human | 0.97220454 |
| 110 | BCOR_27268052_Chip-Seq_Bcells_Human | 0.97177416 |
| 111 | TP53_20018659_ChIP-ChIP_R1E_Mouse | 0.96550566 |
| 112 | SETDB1_19884255_ChIP-Seq_MESCs_Mouse | 0.96529738 |
| 113 | NR0B1_18358816_ChIP-ChIP_MESCs_Mouse | 0.95531811 |
| 114 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 0.94642574 |
| 115 | ZFP281_18358816_ChIP-ChIP_MESCs_Mouse | 0.94254521 |
| 116 | CLOCK_20551151_ChIP-Seq_293T_Human | 0.94118381 |
| 117 | SMAD3_21741376_ChIP-Seq_HESCs_Human | 0.93579021 |
| 118 | AR_25329375_ChIP-Seq_VCAP_Human | 0.92767873 |
| 119 | YAP1_20516196_ChIP-Seq_MESCs_Mouse | 0.92738673 |
| 120 | AHR_22903824_ChIP-Seq_MCF-7_Human | 0.92593194 |
| 121 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 0.90311634 |
| 122 | ZNF217_24962896_ChIP-Seq_MCF-7_Human | 0.90106262 |
| 123 | SMAD4_21741376_ChIP-Seq_HESCs_Human | 0.89923816 |
| 124 | SMAD3_21741376_ChIP-Seq_ESCs_Human | 0.89900197 |
| 125 | ESR1_22446102_ChIP-Seq_UTERUS_Mouse | 0.89017139 |
| 126 | STAT3_23295773_ChIP-Seq_U87_Human | 0.87162663 |
| 127 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 0.86834433 |
| 128 | ARNT_22903824_ChIP-Seq_MCF-7_Human | 0.85514807 |
| 129 | CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 0.85343674 |
| 130 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 0.84549370 |
| 131 | TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.83312935 |
| 132 | SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.82684127 |
| 133 | ESR1_20079471_ChIP-ChIP_T-47D_Human | 0.80879199 |
| 134 | TFAP2A_17053090_ChIP-ChIP_MCF-7_Human | 0.80630029 |
| 135 | KLF4_19829295_ChIP-Seq_ESCs_Human | 0.79332507 |
| 136 | SMC4_20622854_ChIP-Seq_HELA_Human | 0.78035186 |
| 137 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 0.77020134 |
| 138 | * OCT4_19829295_ChIP-Seq_ESCs_Human | 0.76865273 |
| 139 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 0.76583949 |
| 140 | * CREB1_26743006_Chip-Seq_LNCaP_Human | 0.75559927 |
| 141 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 0.75102934 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0004859_abnormal_synaptic_plasticity | 6.77562839 |
| 2 | MP0003635_abnormal_synaptic_transmissio | 4.12974380 |
| 3 | MP0004270_analgesia | 3.98421482 |
| 4 | MP0003880_abnormal_central_pattern | 3.98036190 |
| 5 | MP0002063_abnormal_learning/memory/cond | 3.38296560 |
| 6 | MP0003705_abnormal_hypodermis_morpholog | 3.23793611 |
| 7 | MP0009745_abnormal_behavioral_response | 3.16868071 |
| 8 | MP0002064_seizures | 2.91657079 |
| 9 | MP0005423_abnormal_somatic_nervous | 2.88004015 |
| 10 | MP0001968_abnormal_touch/_nociception | 2.79297935 |
| 11 | MP0002572_abnormal_emotion/affect_behav | 2.70757357 |
| 12 | MP0009046_muscle_twitch | 2.69413900 |
| 13 | MP0002734_abnormal_mechanical_nocicepti | 2.65498500 |
| 14 | MP0009780_abnormal_chondrocyte_physiolo | 2.48447978 |
| 15 | MP0002822_catalepsy | 2.46586579 |
| 16 | MP0004858_abnormal_nervous_system | 2.43194363 |
| 17 | MP0002735_abnormal_chemical_nociception | 2.38718214 |
| 18 | MP0005409_darkened_coat_color | 2.36563231 |
| 19 | MP0002272_abnormal_nervous_system | 2.30078167 |
| 20 | MP0001486_abnormal_startle_reflex | 2.26239456 |
| 21 | MP0000778_abnormal_nervous_system | 2.13010715 |
| 22 | MP0002733_abnormal_thermal_nociception | 2.11229349 |
| 23 | MP0008569_lethality_at_weaning | 2.07091485 |
| 24 | MP0001970_abnormal_pain_threshold | 2.05813260 |
| 25 | MP0004811_abnormal_neuron_physiology | 2.05661673 |
| 26 | MP0002736_abnormal_nociception_after | 2.04403785 |
| 27 | MP0002184_abnormal_innervation | 2.02818121 |
| 28 | MP0003329_amyloid_beta_deposits | 2.00782534 |
| 29 | MP0005058_abnormal_lysosome_morphology | 1.97780589 |
| 30 | MP0001440_abnormal_grooming_behavior | 1.89029551 |
| 31 | MP0002249_abnormal_larynx_morphology | 1.83487775 |
| 32 | MP0002067_abnormal_sensory_capabilities | 1.83300658 |
| 33 | MP0001501_abnormal_sleep_pattern | 1.77578999 |
| 34 | MP0000955_abnormal_spinal_cord | 1.76452898 |
| 35 | MP0002557_abnormal_social/conspecific_i | 1.75277653 |
| 36 | MP0002909_abnormal_adrenal_gland | 1.69577891 |
| 37 | MP0001849_ear_inflammation | 1.63457445 |
| 38 | MP0003123_paternal_imprinting | 1.61868625 |
| 39 | MP0001958_emphysema | 1.61102042 |
| 40 | MP0004885_abnormal_endolymph | 1.58875182 |
| 41 | MP0005386_behavior/neurological_phenoty | 1.56523074 |
| 42 | MP0004924_abnormal_behavior | 1.56523074 |
| 43 | MP0002882_abnormal_neuron_morphology | 1.53099735 |
| 44 | MP0008260_abnormal_autophagy | 1.50291178 |
| 45 | MP0000569_abnormal_digit_pigmentation | 1.48332566 |
| 46 | MP0002066_abnormal_motor_capabilities/c | 1.41533475 |
| 47 | MP0003279_aneurysm | 1.39773530 |
| 48 | MP0008961_abnormal_basal_metabolism | 1.39224812 |
| 49 | MP0006276_abnormal_autonomic_nervous | 1.35790355 |
| 50 | MP0003879_abnormal_hair_cell | 1.33630858 |
| 51 | MP0000751_myopathy | 1.33481021 |
| 52 | MP0003283_abnormal_digestive_organ | 1.29856386 |
| 53 | MP0003633_abnormal_nervous_system | 1.26743630 |
| 54 | MP0002152_abnormal_brain_morphology | 1.25116774 |
| 55 | MP0005076_abnormal_cell_differentiation | 1.22069470 |
| 56 | MP0001984_abnormal_olfaction | 1.19932283 |
| 57 | MP0001502_abnormal_circadian_rhythm | 1.15437985 |
| 58 | MP0008438_abnormal_cutaneous_collagen | 1.14993426 |
| 59 | MP0004130_abnormal_muscle_cell | 1.14674159 |
| 60 | MP0000678_abnormal_parathyroid_gland | 1.12789435 |
| 61 | MP0002090_abnormal_vision | 1.12082105 |
| 62 | MP0003634_abnormal_glial_cell | 1.11431605 |
| 63 | MP0000003_abnormal_adipose_tissue | 1.09339688 |
| 64 | MP0009278_abnormal_bone_marrow | 1.08063736 |
| 65 | MP0003631_nervous_system_phenotype | 1.07571634 |
| 66 | MP0004145_abnormal_muscle_electrophysio | 1.06592349 |
| 67 | MP0005623_abnormal_meninges_morphology | 1.05892067 |
| 68 | MP0010386_abnormal_urinary_bladder | 1.01761464 |
| 69 | MP0005646_abnormal_pituitary_gland | 1.00418103 |
| 70 | MP0003787_abnormal_imprinting | 0.97300709 |
| 71 | MP0004742_abnormal_vestibular_system | 0.95415068 |
| 72 | MP0001529_abnormal_vocalization | 0.94613440 |
| 73 | MP0004142_abnormal_muscle_tone | 0.94364269 |
| 74 | MP0000920_abnormal_myelination | 0.93729972 |
| 75 | MP0003075_altered_response_to | 0.91428563 |
| 76 | MP0005375_adipose_tissue_phenotype | 0.91243963 |
| 77 | MP0005666_abnormal_adipose_tissue | 0.90484463 |
| 78 | MP0001905_abnormal_dopamine_level | 0.89517971 |
| 79 | MP0000579_abnormal_nail_morphology | 0.89081034 |
| 80 | MP0008874_decreased_physiological_sensi | 0.88466123 |
| 81 | MP0003091_abnormal_cell_migration | 0.88081929 |
| 82 | MP0005645_abnormal_hypothalamus_physiol | 0.88034177 |
| 83 | MP0002069_abnormal_eating/drinking_beha | 0.87391528 |
| 84 | MP0005394_taste/olfaction_phenotype | 0.86072681 |
| 85 | MP0005499_abnormal_olfactory_system | 0.86072681 |
| 86 | MP0000566_synostosis | 0.85743794 |
| 87 | MP0001299_abnormal_eye_distance/ | 0.85376022 |
| 88 | MP0004085_abnormal_heartbeat | 0.84774000 |
| 89 | MP0003183_abnormal_peptide_metabolism | 0.82605396 |
| 90 | MP0000013_abnormal_adipose_tissue | 0.82596680 |
| 91 | MP0000604_amyloidosis | 0.82520890 |
| 92 | MP0003861_abnormal_nervous_system | 0.81063128 |
| 93 | MP0001177_atelectasis | 0.79285162 |
| 94 | MP0002229_neurodegeneration | 0.78970368 |
| 95 | MP0003632_abnormal_nervous_system | 0.78887875 |
| 96 | MP0002752_abnormal_somatic_nervous | 0.78413941 |
| 97 | MP0009840_abnormal_foam_cell | 0.78373452 |
| 98 | MP0000631_abnormal_neuroendocrine_gland | 0.77475970 |
| 99 | MP0000681_abnormal_thyroid_gland | 0.77309884 |
| 100 | MP0002751_abnormal_autonomic_nervous | 0.75377988 |
| 101 | MP0000733_abnormal_muscle_development | 0.73952758 |
| 102 | MP0004233_abnormal_muscle_weight | 0.73109097 |
| 103 | MP0003453_abnormal_keratinocyte_physiol | 0.72518735 |
| 104 | MP0003137_abnormal_impulse_conducting | 0.71442323 |
| 105 | MP0003122_maternal_imprinting | 0.71388486 |
| 106 | MP0004185_abnormal_adipocyte_glucose | 0.70643983 |
| 107 | MP0005187_abnormal_penis_morphology | 0.68757379 |
| 108 | MP0004510_myositis | 0.68706597 |
| 109 | MP0008872_abnormal_physiological_respon | 0.68465305 |
| 110 | MP0001348_abnormal_lacrimal_gland | 0.68189925 |
| 111 | MP0001188_hyperpigmentation | 0.67753540 |
| 112 | MP0005670_abnormal_white_adipose | 0.67301981 |
| 113 | MP0003045_fibrosis | 0.66978481 |
| 114 | MP0005257_abnormal_intraocular_pressure | 0.66581496 |
| 115 | MP0009384_cardiac_valve_regurgitation | 0.66014749 |
| 116 | MP0002089_abnormal_postnatal_growth/wei | 0.65758084 |
| 117 | MP0002234_abnormal_pharynx_morphology | 0.65254608 |
| 118 | MP0005167_abnormal_blood-brain_barrier | 0.65034144 |
| 119 | MP0000534_abnormal_ureter_morphology | 0.63792587 |
| 120 | MP0001943_abnormal_respiration | 0.63560399 |
| 121 | MP0005503_abnormal_tendon_morphology | 0.62894288 |
| 122 | MP0000747_muscle_weakness | 0.61904562 |
| 123 | MP0001963_abnormal_hearing_physiology | 0.61860291 |
| 124 | MP0003690_abnormal_glial_cell | 0.61677677 |
| 125 | MP0000759_abnormal_skeletal_muscle | 0.61535815 |
| 126 | MP0005551_abnormal_eye_electrophysiolog | 0.61302804 |
| 127 | MP0002896_abnormal_bone_mineralization | 0.61003940 |
| 128 | MP0010769_abnormal_survival | 0.60538730 |
| 129 | MP0003172_abnormal_lysosome_physiology | 0.60094917 |
| 130 | MP0002837_dystrophic_cardiac_calcinosis | 0.59175649 |
| 131 | MP0003115_abnormal_respiratory_system | 0.58131780 |
| 132 | MP0004215_abnormal_myocardial_fiber | 0.57655212 |
| 133 | MP0003303_peritoneal_inflammation | 0.56547827 |
| 134 | MP0010768_mortality/aging | 0.56395470 |
| 135 | MP0005535_abnormal_body_temperature | 0.55216586 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Myokymia (HP:0002411) | 6.58635948 |
| 2 | Focal motor seizures (HP:0011153) | 5.37732160 |
| 3 | Progressive cerebellar ataxia (HP:0002073) | 5.05128600 |
| 4 | Visual hallucinations (HP:0002367) | 4.71385775 |
| 5 | Focal seizures (HP:0007359) | 4.69777190 |
| 6 | Termporal pattern (HP:0011008) | 4.01530637 |
| 7 | Insidious onset (HP:0003587) | 4.01530637 |
| 8 | Epileptic encephalopathy (HP:0200134) | 3.93398591 |
| 9 | Action tremor (HP:0002345) | 3.86378256 |
| 10 | Supranuclear gaze palsy (HP:0000605) | 3.77750935 |
| 11 | Ankle clonus (HP:0011448) | 3.66313830 |
| 12 | Cerebral aneurysm (HP:0004944) | 3.50544879 |
| 13 | Abnormality of the lower motor neuron (HP:0002366) | 3.21898175 |
| 14 | Atonic seizures (HP:0010819) | 3.17341659 |
| 15 | Depression (HP:0000716) | 3.16952868 |
| 16 | Generalized tonic-clonic seizures (HP:0002069) | 3.02851606 |
| 17 | Papilledema (HP:0001085) | 3.01954086 |
| 18 | Mutism (HP:0002300) | 2.96274807 |
| 19 | Febrile seizures (HP:0002373) | 2.95473982 |
| 20 | Broad face (HP:0000283) | 2.90532698 |
| 21 | Urinary bladder sphincter dysfunction (HP:0002839) | 2.90437089 |
| 22 | Megalencephaly (HP:0001355) | 2.90368667 |
| 23 | Absence seizures (HP:0002121) | 2.89620882 |
| 24 | Upper limb amyotrophy (HP:0009129) | 2.88892652 |
| 25 | Distal upper limb amyotrophy (HP:0007149) | 2.88892652 |
| 26 | Impaired vibration sensation in the lower limbs (HP:0002166) | 2.88555784 |
| 27 | Amblyopia (HP:0000646) | 2.87401566 |
| 28 | Poor eye contact (HP:0000817) | 2.85242248 |
| 29 | Insomnia (HP:0100785) | 2.84524402 |
| 30 | Annular pancreas (HP:0001734) | 2.77516646 |
| 31 | Urinary urgency (HP:0000012) | 2.76857733 |
| 32 | Broad-based gait (HP:0002136) | 2.74694669 |
| 33 | Dysdiadochokinesis (HP:0002075) | 2.70356320 |
| 34 | Obstructive sleep apnea (HP:0002870) | 2.68622277 |
| 35 | Genetic anticipation (HP:0003743) | 2.65802154 |
| 36 | Torticollis (HP:0000473) | 2.64540369 |
| 37 | Dysmetria (HP:0001310) | 2.62913681 |
| 38 | Abnormal social behavior (HP:0012433) | 2.60588547 |
| 39 | Impaired social interactions (HP:0000735) | 2.60588547 |
| 40 | Dialeptic seizures (HP:0011146) | 2.60539193 |
| 41 | Gaze-evoked nystagmus (HP:0000640) | 2.59380772 |
| 42 | Cerebral inclusion bodies (HP:0100314) | 2.58979947 |
| 43 | Pointed chin (HP:0000307) | 2.58121113 |
| 44 | Turricephaly (HP:0000262) | 2.53665368 |
| 45 | Hemiparesis (HP:0001269) | 2.52585059 |
| 46 | Truncal ataxia (HP:0002078) | 2.52063777 |
| 47 | Stridor (HP:0010307) | 2.50846464 |
| 48 | Focal dystonia (HP:0004373) | 2.50055413 |
| 49 | Limb dystonia (HP:0002451) | 2.45712614 |
| 50 | Anxiety (HP:0000739) | 2.44000680 |
| 51 | Protrusio acetabuli (HP:0003179) | 2.43754998 |
| 52 | Neurofibrillary tangles (HP:0002185) | 2.41973988 |
| 53 | Spastic gait (HP:0002064) | 2.41512674 |
| 54 | Postural instability (HP:0002172) | 2.39648423 |
| 55 | Lower limb amyotrophy (HP:0007210) | 2.38635425 |
| 56 | Sleep apnea (HP:0010535) | 2.37480965 |
| 57 | Impaired smooth pursuit (HP:0007772) | 2.35203399 |
| 58 | Abnormal eating behavior (HP:0100738) | 2.34812085 |
| 59 | Hyperacusis (HP:0010780) | 2.32858328 |
| 60 | Spinal canal stenosis (HP:0003416) | 2.31659440 |
| 61 | Hand muscle atrophy (HP:0009130) | 2.31385005 |
| 62 | Pheochromocytoma (HP:0002666) | 2.31293384 |
| 63 | Increased variability in muscle fiber diameter (HP:0003557) | 2.28473294 |
| 64 | Hemiplegia (HP:0002301) | 2.28177419 |
| 65 | Peripheral hypomyelination (HP:0007182) | 2.26744858 |
| 66 | Amyotrophic lateral sclerosis (HP:0007354) | 2.26624758 |
| 67 | Thin bony cortex (HP:0002753) | 2.26540463 |
| 68 | Nuclear cataract (HP:0100018) | 2.25759147 |
| 69 | Abnormality of the corticospinal tract (HP:0002492) | 2.25392907 |
| 70 | Distal lower limb amyotrophy (HP:0008944) | 2.24518582 |
| 71 | Stereotypic behavior (HP:0000733) | 2.22365882 |
| 72 | Bronchomalacia (HP:0002780) | 2.21739592 |
| 73 | Lymphangioma (HP:0100764) | 2.21568913 |
| 74 | Excessive salivation (HP:0003781) | 2.20901525 |
| 75 | Drooling (HP:0002307) | 2.20901525 |
| 76 | J-shaped sella turcica (HP:0002680) | 2.19629269 |
| 77 | Neuroendocrine neoplasm (HP:0100634) | 2.19541951 |
| 78 | Mitral regurgitation (HP:0001653) | 2.18276040 |
| 79 | Lower limb muscle weakness (HP:0007340) | 2.15890135 |
| 80 | Intention tremor (HP:0002080) | 2.13573737 |
| 81 | Epileptiform EEG discharges (HP:0011182) | 2.13371610 |
| 82 | Diplopia (HP:0000651) | 2.13072075 |
| 83 | Abnormality of binocular vision (HP:0011514) | 2.13072075 |
| 84 | Neoplasm of the peripheral nervous system (HP:0100007) | 2.12684863 |
| 85 | EEG with generalized epileptiform discharges (HP:0011198) | 2.12518395 |
| 86 | Dysmetric saccades (HP:0000641) | 2.12050597 |
| 87 | Central scotoma (HP:0000603) | 2.10739184 |
| 88 | Ulnar bowing (HP:0003031) | 2.09876014 |
| 89 | Hypsarrhythmia (HP:0002521) | 2.09269448 |
| 90 | Apathy (HP:0000741) | 2.07809727 |
| 91 | Craniofacial dystonia (HP:0012179) | 2.07715365 |
| 92 | Aplasia involving bones of the extremities (HP:0009825) | 2.06108967 |
| 93 | Aplasia involving bones of the upper limbs (HP:0009823) | 2.06108967 |
| 94 | Aplasia of the phalanges of the hand (HP:0009802) | 2.06108967 |
| 95 | Ventricular fibrillation (HP:0001663) | 2.05588889 |
| 96 | Rapidly progressive (HP:0003678) | 2.04151194 |
| 97 | Abnormality of ocular smooth pursuit (HP:0000617) | 1.99593495 |
| 98 | Scanning speech (HP:0002168) | 1.99390616 |
| 99 | Shoulder girdle muscle weakness (HP:0003547) | 1.95117154 |
| 100 | Bradykinesia (HP:0002067) | 1.94652095 |
| 101 | Cervical subluxation (HP:0003308) | 1.93642643 |
| 102 | Dysostosis multiplex (HP:0000943) | 1.92341127 |
| 103 | Hypercortisolism (HP:0001578) | 1.91984660 |
| 104 | Impaired vibratory sensation (HP:0002495) | 1.91667026 |
| 105 | Akinesia (HP:0002304) | 1.91198029 |
| 106 | Agitation (HP:0000713) | 1.91179788 |
| 107 | Progressive inability to walk (HP:0002505) | 1.91099248 |
| 108 | Difficulty climbing stairs (HP:0003551) | 1.88889858 |
| 109 | Lissencephaly (HP:0001339) | 1.88862554 |
| 110 | Clonus (HP:0002169) | 1.88788209 |
| 111 | Abnormality of skeletal muscle fiber size (HP:0012084) | 1.87950079 |
| 112 | Lower limb asymmetry (HP:0100559) | 1.87715419 |
| 113 | Peritonitis (HP:0002586) | 1.87663537 |
| 114 | Biconcave vertebral bodies (HP:0004586) | 1.85969962 |
| 115 | Onion bulb formation (HP:0003383) | 1.85191976 |
| 116 | Absent speech (HP:0001344) | 1.85104280 |
| 117 | Fetal akinesia sequence (HP:0001989) | 1.84913496 |
| 118 | Broad metatarsal (HP:0001783) | 1.84505210 |
| 119 | Premature rupture of membranes (HP:0001788) | 1.81600225 |
| 120 | Foot dorsiflexor weakness (HP:0009027) | 1.81200122 |
| 121 | Hammertoe (HP:0001765) | 1.80606563 |
| 122 | Incomplete penetrance (HP:0003829) | 1.79711974 |
| 123 | Hypoventilation (HP:0002791) | 1.79157561 |
| 124 | Atrophic scars (HP:0001075) | 1.79117311 |
| 125 | Bladder diverticulum (HP:0000015) | 1.78855194 |
| 126 | Diminished motivation (HP:0000745) | 1.78738196 |
| 127 | Bundle branch block (HP:0011710) | 1.77764691 |
| 128 | Neuronal loss in central nervous system (HP:0002529) | 1.77381870 |
| 129 | Mildly elevated creatine phosphokinase (HP:0008180) | 1.77201178 |
| 130 | Bowel diverticulosis (HP:0005222) | 1.76840022 |
| 131 | Shallow orbits (HP:0000586) | 1.76436860 |
| 132 | Achilles tendon contracture (HP:0001771) | 1.74735079 |
| 133 | Large eyes (HP:0001090) | 1.74711837 |
| 134 | Impaired pain sensation (HP:0007328) | 1.74693439 |
| 135 | Abnormality of pain sensation (HP:0010832) | 1.74693439 |
| 136 | Neoplasm of the heart (HP:0100544) | 1.74178407 |
| 137 | Elfin facies (HP:0004428) | 1.74116572 |
| 138 | Mucopolysacchariduria (HP:0008155) | 1.72414411 |
| 139 | Urinary glycosaminoglycan excretion (HP:0003541) | 1.72414411 |
| 140 | Fragile skin (HP:0001030) | 1.72363290 |
| 141 | Precocious puberty (HP:0000826) | 1.70642303 |
| 142 | Axonal loss (HP:0003447) | 1.69324602 |
| 143 | Tetraplegia (HP:0002445) | 1.68499619 |
| 144 | Distal sensory impairment (HP:0002936) | 1.68384101 |
| 145 | Increased connective tissue (HP:0009025) | 1.67580682 |
| 146 | Abnormality of polysaccharide metabolism (HP:0011012) | 1.67408074 |
| 147 | Abnormality of glycosaminoglycan metabolism (HP:0004371) | 1.67408074 |
| 148 | Abnormality of mucopolysaccharide metabolism (HP:0011020) | 1.67408074 |
| 149 | Bowel incontinence (HP:0002607) | 1.65295540 |
| 150 | Rigidity (HP:0002063) | 1.65246940 |
| 151 | Aneurysm (HP:0002617) | 1.63194193 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MARK1 | 4.05635910 |
| 2 | MAP3K9 | 3.65729523 |
| 3 | NTRK3 | 3.63718245 |
| 4 | EPHA4 | 3.58600373 |
| 5 | DAPK2 | 2.92173781 |
| 6 | MINK1 | 2.65811018 |
| 7 | PAK6 | 2.64179808 |
| 8 | SIK1 | 2.51447925 |
| 9 | CAMKK1 | 2.28252940 |
| 10 | PRKD3 | 2.25297134 |
| 11 | MAP3K4 | 2.25190615 |
| 12 | NTRK1 | 2.24902275 |
| 13 | NTRK2 | 2.17580287 |
| 14 | KSR2 | 2.17370864 |
| 15 | SIK2 | 1.75799948 |
| 16 | KSR1 | 1.68260747 |
| 17 | CDK5 | 1.61296620 |
| 18 | TYRO3 | 1.61126723 |
| 19 | TNK2 | 1.56970974 |
| 20 | ERN1 | 1.53155123 |
| 21 | RIPK4 | 1.46676376 |
| 22 | TAOK1 | 1.46551074 |
| 23 | MAPK13 | 1.46458463 |
| 24 | MAP2K7 | 1.45390789 |
| 25 | EEF2K | 1.41952200 |
| 26 | DAPK1 | 1.41255151 |
| 27 | UHMK1 | 1.40081846 |
| 28 | PHKG2 | 1.38505876 |
| 29 | PHKG1 | 1.38505876 |
| 30 | FGFR4 | 1.34547032 |
| 31 | PRPF4B | 1.34423814 |
| 32 | SMG1 | 1.32733256 |
| 33 | RIPK1 | 1.31675177 |
| 34 | MAP2K4 | 1.29793708 |
| 35 | STK38 | 1.27070544 |
| 36 | PLK2 | 1.21506417 |
| 37 | TRIB3 | 1.19947376 |
| 38 | GRK5 | 1.19671042 |
| 39 | STK11 | 1.17243384 |
| 40 | LATS2 | 1.11920867 |
| 41 | MAP3K2 | 1.08803249 |
| 42 | FES | 1.08795184 |
| 43 | CDK19 | 1.08621278 |
| 44 | RET | 1.06945351 |
| 45 | MAP3K6 | 1.06728670 |
| 46 | CDK14 | 1.06723746 |
| 47 | TNIK | 1.05610085 |
| 48 | PRKCH | 1.04263279 |
| 49 | CDK15 | 1.02453245 |
| 50 | CDK12 | 1.01059590 |
| 51 | CASK | 1.01024700 |
| 52 | CDK18 | 1.00633359 |
| 53 | LIMK1 | 0.98048976 |
| 54 | CAMKK2 | 0.97733856 |
| 55 | MARK2 | 0.97010996 |
| 56 | MAP2K3 | 0.96959292 |
| 57 | PRKCG | 0.94102031 |
| 58 | TTN | 0.93986147 |
| 59 | PTK2 | 0.93513991 |
| 60 | CDK11A | 0.90759991 |
| 61 | MAP2K6 | 0.90500178 |
| 62 | ALK | 0.87949803 |
| 63 | SGK494 | 0.79887722 |
| 64 | SGK223 | 0.79887722 |
| 65 | CAMK1 | 0.79530949 |
| 66 | MTOR | 0.79099088 |
| 67 | CAMK2A | 0.77968775 |
| 68 | SCYL2 | 0.77473616 |
| 69 | PAK3 | 0.77044361 |
| 70 | PTK2B | 0.75886417 |
| 71 | PTK6 | 0.74759553 |
| 72 | MAP3K11 | 0.73178446 |
| 73 | LMTK2 | 0.73170081 |
| 74 | BMX | 0.72632179 |
| 75 | DYRK1A | 0.72312115 |
| 76 | EPHB2 | 0.71638119 |
| 77 | PNCK | 0.71192754 |
| 78 | ERBB2 | 0.70884517 |
| 79 | MAP3K13 | 0.70680075 |
| 80 | RPS6KA2 | 0.69021569 |
| 81 | FGFR2 | 0.68279489 |
| 82 | WNK1 | 0.65929979 |
| 83 | CSNK1G2 | 0.65865616 |
| 84 | CAMK1G | 0.64889302 |
| 85 | MAP3K12 | 0.63476391 |
| 86 | PRKCZ | 0.63267828 |
| 87 | EPHB1 | 0.63222372 |
| 88 | SGK3 | 0.62874183 |
| 89 | CAMK2B | 0.62854792 |
| 90 | ICK | 0.62676932 |
| 91 | DAPK3 | 0.62298512 |
| 92 | NEK6 | 0.61970715 |
| 93 | PDGFRA | 0.61503048 |
| 94 | DDR2 | 0.60523767 |
| 95 | FYN | 0.60230350 |
| 96 | DYRK1B | 0.60030324 |
| 97 | FGR | 0.59638467 |
| 98 | RPS6KC1 | 0.59257883 |
| 99 | RPS6KL1 | 0.59257883 |
| 100 | PDGFRB | 0.58676400 |
| 101 | CAMK4 | 0.58574132 |
| 102 | HIPK2 | 0.57952080 |
| 103 | MAP3K1 | 0.57224700 |
| 104 | CAMK2G | 0.57218367 |
| 105 | PKN1 | 0.56223014 |
| 106 | PRKD2 | 0.55917323 |
| 107 | SGK1 | 0.55437025 |
| 108 | MAPK15 | 0.54941534 |
| 109 | CAMK1D | 0.54033791 |
| 110 | RAF1 | 0.52828129 |
| 111 | MAP3K7 | 0.52222452 |
| 112 | CDC42BPA | 0.51395268 |
| 113 | ROCK2 | 0.49376254 |
| 114 | MAPK10 | 0.48908992 |
| 115 | DMPK | 0.48663808 |
| 116 | DYRK2 | 0.48553364 |
| 117 | MAP2K1 | 0.47992965 |
| 118 | PRKD1 | 0.47887622 |
| 119 | MAPK8 | 0.47747488 |
| 120 | PDK1 | 0.47636827 |
| 121 | RPS6KA3 | 0.45725726 |
| 122 | PDPK1 | 0.45654075 |
| 123 | SGK2 | 0.45332406 |
| 124 | IRAK3 | 0.45301172 |
| 125 | MAPK7 | 0.44696294 |
| 126 | FGFR3 | 0.44205145 |
| 127 | PKN2 | 0.43629989 |
| 128 | TESK1 | 0.42884785 |
| 129 | MAPK12 | 0.41006062 |
| 130 | ARAF | 0.39927000 |
| 131 | BRSK1 | 0.39341872 |
| 132 | ERBB3 | 0.39333722 |
| 133 | NEK1 | 0.38758469 |
| 134 | PRKCE | 0.35619111 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Nicotine addiction_Homo sapiens_hsa05033 | 2.78562105 |
| 2 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 2.77780938 |
| 3 | Olfactory transduction_Homo sapiens_hsa04740 | 2.52798472 |
| 4 | Circadian entrainment_Homo sapiens_hsa04713 | 2.51001264 |
| 5 | Long-term potentiation_Homo sapiens_hsa04720 | 2.40912354 |
| 6 | Glutamatergic synapse_Homo sapiens_hsa04724 | 2.32679522 |
| 7 | GABAergic synapse_Homo sapiens_hsa04727 | 2.28886166 |
| 8 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 2.23832186 |
| 9 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 2.23616469 |
| 10 | Morphine addiction_Homo sapiens_hsa05032 | 2.19105254 |
| 11 | Amphetamine addiction_Homo sapiens_hsa05031 | 2.09913658 |
| 12 | Dopaminergic synapse_Homo sapiens_hsa04728 | 2.05200738 |
| 13 | Salivary secretion_Homo sapiens_hsa04970 | 1.94887175 |
| 14 | Cholinergic synapse_Homo sapiens_hsa04725 | 1.94109348 |
| 15 | Insulin secretion_Homo sapiens_hsa04911 | 1.85293158 |
| 16 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 1.81989398 |
| 17 | Gastric acid secretion_Homo sapiens_hsa04971 | 1.81373059 |
| 18 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 1.76481418 |
| 19 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 1.69916265 |
| 20 | Renin secretion_Homo sapiens_hsa04924 | 1.65341023 |
| 21 | Long-term depression_Homo sapiens_hsa04730 | 1.60976902 |
| 22 | Other glycan degradation_Homo sapiens_hsa00511 | 1.59765397 |
| 23 | Gap junction_Homo sapiens_hsa04540 | 1.55896935 |
| 24 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 1.54548166 |
| 25 | GnRH signaling pathway_Homo sapiens_hsa04912 | 1.53362161 |
| 26 | Cocaine addiction_Homo sapiens_hsa05030 | 1.51534545 |
| 27 | Notch signaling pathway_Homo sapiens_hsa04330 | 1.50596290 |
| 28 | Glioma_Homo sapiens_hsa05214 | 1.47292646 |
| 29 | Axon guidance_Homo sapiens_hsa04360 | 1.43223942 |
| 30 | Taste transduction_Homo sapiens_hsa04742 | 1.42098261 |
| 31 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 1.38567704 |
| 32 | Serotonergic synapse_Homo sapiens_hsa04726 | 1.38455463 |
| 33 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 1.35683914 |
| 34 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 1.33580187 |
| 35 | Calcium signaling pathway_Homo sapiens_hsa04020 | 1.33370604 |
| 36 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 1.20083865 |
| 37 | cAMP signaling pathway_Homo sapiens_hsa04024 | 1.17161731 |
| 38 | ErbB signaling pathway_Homo sapiens_hsa04012 | 1.16400651 |
| 39 | Melanogenesis_Homo sapiens_hsa04916 | 1.14514808 |
| 40 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 1.12224863 |
| 41 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 1.10517253 |
| 42 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 1.10380783 |
| 43 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 1.07195320 |
| 44 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 1.06970075 |
| 45 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 1.04759877 |
| 46 | VEGF signaling pathway_Homo sapiens_hsa04370 | 1.04259124 |
| 47 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 1.01150722 |
| 48 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 1.00963221 |
| 49 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 1.00055367 |
| 50 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.92314294 |
| 51 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.89844831 |
| 52 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.89578042 |
| 53 | Bile secretion_Homo sapiens_hsa04976 | 0.89445392 |
| 54 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.89400734 |
| 55 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.83416339 |
| 56 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.82922296 |
| 57 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.82805613 |
| 58 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.82322398 |
| 59 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.81764044 |
| 60 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.81503294 |
| 61 | Endometrial cancer_Homo sapiens_hsa05213 | 0.81152945 |
| 62 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.80954906 |
| 63 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.80224265 |
| 64 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 0.79892863 |
| 65 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.79725550 |
| 66 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.76823597 |
| 67 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.76469526 |
| 68 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.75798483 |
| 69 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.74366869 |
| 70 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.74148978 |
| 71 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.73759354 |
| 72 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.73363008 |
| 73 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.72698307 |
| 74 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.72674209 |
| 75 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 0.72370225 |
| 76 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.72067827 |
| 77 | * Endocytosis_Homo sapiens_hsa04144 | 0.71624023 |
| 78 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 0.71622793 |
| 79 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.66766186 |
| 80 | Amoebiasis_Homo sapiens_hsa05146 | 0.66176066 |
| 81 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.65798931 |
| 82 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.64985927 |
| 83 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 0.64521110 |
| 84 | Colorectal cancer_Homo sapiens_hsa05210 | 0.63814754 |
| 85 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.61609705 |
| 86 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.61608108 |
| 87 | Alcoholism_Homo sapiens_hsa05034 | 0.60324299 |
| 88 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.60215247 |
| 89 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.60050852 |
| 90 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.59482506 |
| 91 | ECM-receptor interaction_Homo sapiens_hsa04512 | 0.59453675 |
| 92 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 0.59233164 |
| 93 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.58049839 |
| 94 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 0.57839425 |
| 95 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.56500065 |
| 96 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.55441524 |
| 97 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.55424224 |
| 98 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.54661365 |
| 99 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.52660969 |
| 100 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.52305483 |
| 101 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.52245812 |
| 102 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 0.50831893 |
| 103 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.49772077 |
| 104 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 0.49671195 |
| 105 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 0.49510977 |
| 106 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.49377502 |
| 107 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.49263248 |
| 108 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.48965287 |
| 109 | Phototransduction_Homo sapiens_hsa04744 | 0.48816516 |
| 110 | Osteoclast differentiation_Homo sapiens_hsa04380 | 0.47767436 |
| 111 | Platelet activation_Homo sapiens_hsa04611 | 0.47474853 |
| 112 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.46543551 |
| 113 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 0.46366978 |
| 114 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.46125149 |
| 115 | Prion diseases_Homo sapiens_hsa05020 | 0.45503397 |
| 116 | Circadian rhythm_Homo sapiens_hsa04710 | 0.41573996 |
| 117 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.40841233 |
| 118 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.39785266 |
| 119 | Focal adhesion_Homo sapiens_hsa04510 | 0.38729122 |
| 120 | Bladder cancer_Homo sapiens_hsa05219 | 0.38465864 |
| 121 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.38366534 |

