ACAT1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a mitochondrially localized enzyme that catalyzes the reversible formation of acetoacetyl-CoA from two molecules of acetyl-CoA. Defects in this gene are associated with 3-ketothiolase deficiency, an inborn error of isoleucine catabolism characterized by urinary excretion of 2-methyl-3-hydroxybutyric acid, 2-methylacetoacetic acid, tiglylglycine, and butanone. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)6.54508888
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.54508888
3L-phenylalanine metabolic process (GO:0006558)6.31744600
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.31744600
5glyoxylate metabolic process (GO:0046487)5.80887423
6lysine catabolic process (GO:0006554)5.80067966
7lysine metabolic process (GO:0006553)5.80067966
8aromatic amino acid family catabolic process (GO:0009074)5.72880339
9alpha-linolenic acid metabolic process (GO:0036109)5.19842206
10triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.12992413
11fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.11599056
12kynurenine metabolic process (GO:0070189)5.06081889
13indole-containing compound catabolic process (GO:0042436)5.02189622
14indolalkylamine catabolic process (GO:0046218)5.02189622
15tryptophan catabolic process (GO:0006569)5.02189622
16cysteine metabolic process (GO:0006534)4.92300338
17bile acid biosynthetic process (GO:0006699)4.88678509
18fatty acid beta-oxidation (GO:0006635)4.78753764
19tryptophan metabolic process (GO:0006568)4.78576943
20amino-acid betaine metabolic process (GO:0006577)4.74802763
21* cellular ketone body metabolic process (GO:0046950)4.69472017
22short-chain fatty acid metabolic process (GO:0046459)4.64450419
23sulfur amino acid catabolic process (GO:0000098)4.64392819
242-oxoglutarate metabolic process (GO:0006103)4.52413102
25epoxygenase P450 pathway (GO:0019373)4.47839697
26aspartate family amino acid catabolic process (GO:0009068)4.47387706
27fatty acid oxidation (GO:0019395)4.46308631
28acetyl-CoA metabolic process (GO:0006084)4.42871397
29fatty acid catabolic process (GO:0009062)4.40418361
30regulation of triglyceride catabolic process (GO:0010896)4.40212445
31serine family amino acid catabolic process (GO:0009071)4.39429203
32lipid oxidation (GO:0034440)4.37743949
33urea cycle (GO:0000050)4.31341535
34urea metabolic process (GO:0019627)4.31341535
35alpha-amino acid catabolic process (GO:1901606)4.27527210
36omega-hydroxylase P450 pathway (GO:0097267)4.27183239
37homocysteine metabolic process (GO:0050667)4.23515600
38monocarboxylic acid catabolic process (GO:0072329)4.22907781
39high-density lipoprotein particle remodeling (GO:0034375)4.20473982
40aromatic amino acid family metabolic process (GO:0009072)4.19983082
41bile acid metabolic process (GO:0008206)4.10779859
42negative regulation of fibrinolysis (GO:0051918)4.10198874
43fatty acid transmembrane transport (GO:1902001)4.08906692
44tyrosine metabolic process (GO:0006570)4.05559957
45carnitine metabolic process (GO:0009437)4.05518757
46peptidyl-glutamic acid carboxylation (GO:0017187)4.05050400
47protein carboxylation (GO:0018214)4.05050400
48muscle filament sliding (GO:0030049)4.04852574
49actin-myosin filament sliding (GO:0033275)4.04852574
50coenzyme catabolic process (GO:0009109)4.03798058
51* cellular amino acid catabolic process (GO:0009063)4.03609013
52nitrogen cycle metabolic process (GO:0071941)4.01587244
53* ketone body metabolic process (GO:1902224)4.01425269
54valine metabolic process (GO:0006573)4.01262607
55regulation of fibrinolysis (GO:0051917)3.98199107
56drug transmembrane transport (GO:0006855)3.98035428
57acylglycerol homeostasis (GO:0055090)3.95266844
58triglyceride homeostasis (GO:0070328)3.95266844
59tricarboxylic acid cycle (GO:0006099)3.94517450
60complement activation, alternative pathway (GO:0006957)3.94353650
61carnitine shuttle (GO:0006853)3.94252199
62* organic acid catabolic process (GO:0016054)3.90877782
63* carboxylic acid catabolic process (GO:0046395)3.90877782
64* branched-chain amino acid catabolic process (GO:0009083)3.89966427
65cellular modified amino acid catabolic process (GO:0042219)3.87539100
66ethanol oxidation (GO:0006069)3.87333367
67drug catabolic process (GO:0042737)3.84442682
68regulation of protein activation cascade (GO:2000257)3.83697479
69glutamate metabolic process (GO:0006536)3.83304798
70tricarboxylic acid metabolic process (GO:0072350)3.81328612
71urate metabolic process (GO:0046415)3.79311820
72positive regulation of fatty acid beta-oxidation (GO:0032000)3.79241547
73regulation of hexokinase activity (GO:1903299)3.79080817
74regulation of glucokinase activity (GO:0033131)3.79080817
75* branched-chain amino acid metabolic process (GO:0009081)3.75187677
76reverse cholesterol transport (GO:0043691)3.72128467
77protein-lipid complex remodeling (GO:0034368)3.69022430
78macromolecular complex remodeling (GO:0034367)3.69022430
79plasma lipoprotein particle remodeling (GO:0034369)3.69022430
80oxidative demethylation (GO:0070989)3.68469586
81dicarboxylic acid biosynthetic process (GO:0043650)3.68009934
82regulation of cholesterol esterification (GO:0010872)3.67531218
83fatty acid homeostasis (GO:0055089)3.67336371
84succinate metabolic process (GO:0006105)3.65545920
85plasma lipoprotein particle clearance (GO:0034381)3.64344943
86indolalkylamine metabolic process (GO:0006586)3.60218111
87benzene-containing compound metabolic process (GO:0042537)3.58714069
88serine family amino acid metabolic process (GO:0009069)3.58043991
89positive regulation of fatty acid oxidation (GO:0046321)3.57672564
90regulation of complement activation (GO:0030449)3.56912667
91positive regulation of lipid catabolic process (GO:0050996)3.53559947
92biotin metabolic process (GO:0006768)3.53129357
93positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.52836175
94oxaloacetate metabolic process (GO:0006107)3.49406170
95cellular glucuronidation (GO:0052695)3.46814186
96phospholipid homeostasis (GO:0055091)3.46526495
97creatine metabolic process (GO:0006600)3.45697634
98L-methionine salvage (GO:0071267)3.45683125
99L-methionine biosynthetic process (GO:0071265)3.45683125
100amino acid salvage (GO:0043102)3.45683125
101NADH metabolic process (GO:0006734)3.45616823
102drug metabolic process (GO:0017144)3.45090428
103regulation of sequestering of triglyceride (GO:0010889)3.44749756
104aldehyde catabolic process (GO:0046185)3.44135227
105regulation of fatty acid oxidation (GO:0046320)3.42275796
106phospholipid efflux (GO:0033700)3.41395996
107negative regulation of sterol transport (GO:0032372)3.39659389
108negative regulation of cholesterol transport (GO:0032375)3.39659389
109cellular biogenic amine catabolic process (GO:0042402)3.38247871
110amine catabolic process (GO:0009310)3.38247871
111carnitine transport (GO:0015879)3.37691003
112amino-acid betaine transport (GO:0015838)3.37691003
113glucuronate metabolic process (GO:0019585)3.37666965
114uronic acid metabolic process (GO:0006063)3.37666965
115xenobiotic catabolic process (GO:0042178)3.36571065
116exogenous drug catabolic process (GO:0042738)3.36267305
117glycine metabolic process (GO:0006544)3.33535422
118blood coagulation, intrinsic pathway (GO:0007597)3.32798835
119actin-mediated cell contraction (GO:0070252)3.32096063
120mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.27214723
121phenylpropanoid metabolic process (GO:0009698)3.25694932
122fructose metabolic process (GO:0006000)3.19556070
123positive regulation of glycolytic process (GO:0045821)3.18179091
124oxidative phosphorylation (GO:0006119)3.16921576
125mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.16047043
126regulation of relaxation of muscle (GO:1901077)3.15708689
127regulation of skeletal muscle contraction (GO:0014819)3.13451430
128respiratory electron transport chain (GO:0022904)3.12795305
129glycogen catabolic process (GO:0005980)3.07955265
130S-adenosylmethionine metabolic process (GO:0046500)3.07537774
131gluconeogenesis (GO:0006094)3.06686814
132electron transport chain (GO:0022900)3.04778413
133response to mercury ion (GO:0046689)2.96274113
134negative regulation of protein activation cascade (GO:2000258)2.96266302
135fibrinolysis (GO:0042730)2.96038439
136regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.95758171
137ethanol metabolic process (GO:0006067)2.91476300
138regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.89964575
139sarcoplasmic reticulum calcium ion transport (GO:0070296)2.89845587
140hexose biosynthetic process (GO:0019319)2.87403561
141polyketide metabolic process (GO:0030638)2.82287603
142doxorubicin metabolic process (GO:0044598)2.82287603
143daunorubicin metabolic process (GO:0044597)2.82287603
144methionine biosynthetic process (GO:0009086)2.81056615
145skeletal muscle contraction (GO:0003009)2.76471237
146carnitine transmembrane transport (GO:1902603)2.76452190

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse7.25316816
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse7.05247533
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.20555575
4LXR_22158963_ChIP-Seq_LIVER_Mouse5.66607693
5EGR1_23403033_ChIP-Seq_LIVER_Mouse5.22212696
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.60275534
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.94909328
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.67105616
9TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.35031465
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.33594762
11CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.98346845
12* ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.27715286
13GABP_17652178_ChIP-ChIP_JURKAT_Human2.22835979
14* SRF_21415370_ChIP-Seq_HL-1_Mouse2.18113313
15POU3F2_20337985_ChIP-ChIP_501MEL_Human2.14328567
16HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.11212866
17CLOCK_20551151_ChIP-Seq_293T_Human2.08957563
18ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.3555105
19TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.97750297
20EST1_17652178_ChIP-ChIP_JURKAT_Human1.92639796
21JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.89890100
22NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.83050833
23IGF1R_20145208_ChIP-Seq_DFB_Human1.78253915
24PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.73506624
25VDR_22108803_ChIP-Seq_LS180_Human1.69200590
26CREB1_15753290_ChIP-ChIP_HEK293T_Human1.61064174
27HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.54068484
28FOXA2_19822575_ChIP-Seq_HepG2_Human1.50959319
29GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.50388049
30PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.44699581
31GATA1_22025678_ChIP-Seq_K562_Human1.44649802
32FLI1_27457419_Chip-Seq_LIVER_Mouse1.44466796
33ETS1_20019798_ChIP-Seq_JURKAT_Human1.39425375
34EZH2_27294783_Chip-Seq_NPCs_Mouse1.36981553
35HTT_18923047_ChIP-ChIP_STHdh_Human1.35593284
36NFE2_27457419_Chip-Seq_LIVER_Mouse1.32450168
37RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.31480716
38HNF4A_19822575_ChIP-Seq_HepG2_Human1.30463668
39ELK1_19687146_ChIP-ChIP_HELA_Human1.28485000
40PHF8_20622853_ChIP-Seq_HELA_Human1.27518106
41SUZ12_27294783_Chip-Seq_NPCs_Mouse1.26590617
42* FUS_26573619_Chip-Seq_HEK293_Human1.26555100
43ER_23166858_ChIP-Seq_MCF-7_Human1.25411591
44DCP1A_22483619_ChIP-Seq_HELA_Human1.24770715
45TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21033071
46ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.20893104
47CRX_20693478_ChIP-Seq_RETINA_Mouse1.20382064
48PADI4_21655091_ChIP-ChIP_MCF-7_Human1.20179224
49BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.19674562
50FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.18855690
51ZFP57_27257070_Chip-Seq_ESCs_Mouse1.18048783
52PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.17287830
53MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.15352062
54RARG_19884340_ChIP-ChIP_MEFs_Mouse1.15182152
55* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.14731016
56PCGF2_27294783_Chip-Seq_ESCs_Mouse1.12462251
57PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.12319899
58CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.09922088
59EP300_21415370_ChIP-Seq_HL-1_Mouse1.09268536
60HNFA_21074721_ChIP-Seq_CACO-2_Human1.08959499
61THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.08495183
62ESR1_20079471_ChIP-ChIP_T-47D_Human1.07852198
63ZNF263_19887448_ChIP-Seq_K562_Human1.06308238
64MYC_18555785_ChIP-Seq_MESCs_Mouse1.05487783
65AR_21909140_ChIP-Seq_LNCAP_Human1.04885099
66* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.03021279
67BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.01402289
68NFYB_21822215_ChIP-Seq_K562_Human1.01068892
69EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.00278059
70* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.00269063
71* VDR_23849224_ChIP-Seq_CD4+_Human1.00205584
72THAP11_20581084_ChIP-Seq_MESCs_Mouse1.00046447
73SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.98432040
74E2F1_18555785_ChIP-Seq_MESCs_Mouse0.97961881
75AUTS2_25519132_ChIP-Seq_293T-REX_Human0.97114732
76OCT4_21477851_ChIP-Seq_ESCs_Mouse0.97042237
77STAT3_18555785_Chip-Seq_ESCs_Mouse0.96661651
78CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.96340711
79GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.95920534
80GATA6_21074721_ChIP-Seq_CACO-2_Human0.95626777
81TFEB_21752829_ChIP-Seq_HELA_Human0.94542328
82SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.94434533
83CTBP2_25329375_ChIP-Seq_LNCAP_Human0.94384976
84RBPJ_21746931_ChIP-Seq_IB4_Human0.94200493
85CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.93622708
86* TBX20_22080862_ChIP-Seq_HEART_Mouse0.93078326
87* TBX20_22328084_ChIP-Seq_HEART_Mouse0.93078326
88PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.92259024
89TAF15_26573619_Chip-Seq_HEK293_Human0.91883991
90NFYA_21822215_ChIP-Seq_K562_Human0.91857118
91CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.89829690
92ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.89275652
93UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.89271948
94PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.89255269
95SALL4_22934838_ChIP-ChIP_CD34+_Human0.88995823
96FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.88744775
97NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.85833039
98NRF2_20460467_ChIP-Seq_MEFs_Mouse0.85833039
99SOX2_27498859_Chip-Seq_STOMACH_Mouse0.84318926
100BCAT_22108803_ChIP-Seq_LS180_Human0.83161515
101SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.82284463
102AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.81172167
103RXRA_24833708_ChIP-Seq_LIVER_Mouse0.77254609
104EGR1_19032775_ChIP-ChIP_M12_Human0.76522977
105GATA4_25053715_ChIP-Seq_YYC3_Human0.75522403
106PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.71485076
107PIAS1_25552417_ChIP-Seq_VCAP_Human0.70592294
108NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.68078492
109ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.67252148
110ESR2_21235772_ChIP-Seq_MCF-7_Human0.67100585
111CDX2_19796622_ChIP-Seq_MESCs_Mouse0.66403362
112STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.65685143
113AR_20517297_ChIP-Seq_VCAP_Human0.65056058
114EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.63701246
115RAD21_21589869_ChIP-Seq_MESCs_Mouse0.63577066
116PPAR_26484153_Chip-Seq_NCI-H1993_Human0.62441227
117NR3C1_23031785_ChIP-Seq_PC12_Mouse0.62231905
118GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.62099960
119ERG_20517297_ChIP-Seq_VCAP_Human0.60904622
120PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.60847496
121* CBP_21632823_ChIP-Seq_H3396_Human0.60701625
122PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.60093172
123PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.59823972
124PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.59645134
125SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.57820612
126E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.57801556
127BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.56917477
128* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.54137567
129* CEBPB_22108803_ChIP-Seq_LS180_Human0.53169929
130FOXA1_25552417_ChIP-Seq_VCAP_Human0.51982080
131FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.51434449
132TAF2_19829295_ChIP-Seq_ESCs_Human0.49709994
133NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.49611002
134* CBP_20019798_ChIP-Seq_JUKART_Human0.49165610
135* IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.49165610
136AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.48601353
137ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.48530784
138SALL4_18804426_ChIP-ChIP_XEN_Mouse0.48166594
139GBX2_23144817_ChIP-Seq_PC3_Human0.48007066
140NANOG_19829295_ChIP-Seq_ESCs_Human0.47289001
141SOX2_19829295_ChIP-Seq_ESCs_Human0.47289001
142SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.47012923
143ESR1_21235772_ChIP-Seq_MCF-7_Human0.46632978
144SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.45527150
145KAP1_22055183_ChIP-Seq_ESCs_Mouse0.45202200
146OCT4_20526341_ChIP-Seq_ESCs_Human0.45173211
147MYC_19915707_ChIP-ChIP_AK7_Human0.45090243
148STAT1_17558387_ChIP-Seq_HELA_Human0.44464955
149SMAD4_21741376_ChIP-Seq_HESCs_Human0.44251265
150RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.43944343
151* GATA2_19941826_ChIP-Seq_K562_Human0.43841180
152ESET_19884257_ChIP-Seq_ESCs_Mouse0.43785544
153* CDX2_22108803_ChIP-Seq_LS180_Human0.43461917
154CDX2_20551321_ChIP-Seq_CACO-2_Human0.43390409
155IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.43300204
156SMAD4_21741376_ChIP-Seq_EPCs_Human0.43276419
157* GATA4_21415370_ChIP-Seq_HL-1_Mouse0.43263536
158SOX2_21211035_ChIP-Seq_LN229_Gbm0.43230733
159P53_21459846_ChIP-Seq_SAOS-2_Human0.43079466
160GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.42879510

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.24380758
2MP0005360_urolithiasis6.78959162
3MP0005085_abnormal_gallbladder_physiolo5.51174811
4MP0005365_abnormal_bile_salt5.37638050
5MP0008875_abnormal_xenobiotic_pharmacok4.28786713
6MP0003806_abnormal_nucleotide_metabolis3.54462571
7MP0003252_abnormal_bile_duct3.38616080
8MP0010329_abnormal_lipoprotein_level3.20234825
9MP0004145_abnormal_muscle_electrophysio3.14032356
10MP0005332_abnormal_amino_acid3.08367407
11MP0002837_dystrophic_cardiac_calcinosis3.05644837
12MP0003195_calcinosis3.00964800
13MP0005083_abnormal_biliary_tract2.41429875
14MP0009840_abnormal_foam_cell2.35473229
15MP0001666_abnormal_nutrient_absorption2.34061176
16MP0002118_abnormal_lipid_homeostasis2.13808276
17MP0004019_abnormal_vitamin_homeostasis2.09719891
18MP0004130_abnormal_muscle_cell2.05515236
19MP0000372_irregular_coat_pigmentation2.05066834
20MP0003191_abnormal_cellular_cholesterol2.03235128
21MP0003646_muscle_fatigue1.94123617
22MP0006036_abnormal_mitochondrial_physio1.90945376
23MP0000609_abnormal_liver_physiology1.86550405
24MP0002138_abnormal_hepatobiliary_system1.83748010
25MP0005319_abnormal_enzyme/_coenzyme1.80575287
26MP0005584_abnormal_enzyme/coenzyme_acti1.74948078
27MP0005670_abnormal_white_adipose1.72918710
28MP0009643_abnormal_urine_homeostasis1.65869738
29MP0010234_abnormal_vibrissa_follicle1.58798074
30MP0001764_abnormal_homeostasis1.55326521
31MP0004043_abnormal_pH_regulation1.54567726
32MP0003868_abnormal_feces_composition1.49303916
33MP0005451_abnormal_body_composition1.48510695
34MP0003950_abnormal_plasma_membrane1.43558589
35MP0000759_abnormal_skeletal_muscle1.40776375
36MP0004233_abnormal_muscle_weight1.37552374
37MP0005330_cardiomyopathy1.35465446
38MP0005369_muscle_phenotype1.35399635
39MP0005666_abnormal_adipose_tissue1.33731936
40MP0004215_abnormal_myocardial_fiber1.33512060
41MP0005187_abnormal_penis_morphology1.33309003
42MP0003186_abnormal_redox_activity1.27748300
43MP0005636_abnormal_mineral_homeostasis1.27389648
44MP0005535_abnormal_body_temperature1.27241725
45MP0000751_myopathy1.26459795
46MP0002971_abnormal_brown_adipose1.22275538
47MP0005379_endocrine/exocrine_gland_phen1.20410596
48MP0004036_abnormal_muscle_relaxation1.20165942
49MP0002078_abnormal_glucose_homeostasis1.17730147
50MP0002876_abnormal_thyroid_physiology1.17341981
51MP0004084_abnormal_cardiac_muscle1.16572866
52MP0009697_abnormal_copulation1.15737024
53MP0006035_abnormal_mitochondrial_morpho1.10076539
54MP0001756_abnormal_urination1.03486210
55MP0003656_abnormal_erythrocyte_physiolo0.95353573
56MP0000003_abnormal_adipose_tissue0.94220670
57MP0002638_abnormal_pupillary_reflex0.94214911
58MP0005084_abnormal_gallbladder_morpholo0.93705575
59MP0002090_abnormal_vision0.92282929
60MP0005334_abnormal_fat_pad0.92262632
61MP0000598_abnormal_liver_morphology0.92216152
62MP0003718_maternal_effect0.91276006
63MP0010368_abnormal_lymphatic_system0.90782758
64MP0003011_delayed_dark_adaptation0.89653219
65MP0000230_abnormal_systemic_arterial0.87560019
66MP0009642_abnormal_blood_homeostasis0.87334075
67MP0002972_abnormal_cardiac_muscle0.86066884
68MP0000750_abnormal_muscle_regeneration0.85572633
69MP0000749_muscle_degeneration0.85253942
70MP0005620_abnormal_muscle_contractility0.82456943
71MP0001944_abnormal_pancreas_morphology0.82443006
72MP0005645_abnormal_hypothalamus_physiol0.82115431
73MP0000604_amyloidosis0.82081854
74MP0002269_muscular_atrophy0.81783721
75MP0003221_abnormal_cardiomyocyte_apopto0.79776853
76MP0001544_abnormal_cardiovascular_syste0.79309809
77MP0005385_cardiovascular_system_phenoty0.79309809
78MP0004087_abnormal_muscle_fiber0.79166303
79MP0008775_abnormal_heart_ventricle0.78256190
80MP0001765_abnormal_ion_homeostasis0.77755267
81MP0003705_abnormal_hypodermis_morpholog0.77698928
82MP0001661_extended_life_span0.77576196
83MP0005266_abnormal_metabolism0.77167217
84MP0005220_abnormal_exocrine_pancreas0.76030357
85MP0005376_homeostasis/metabolism_phenot0.75200963
86MP0004185_abnormal_adipocyte_glucose0.75096435
87MP0005375_adipose_tissue_phenotype0.74270393
88MP0005448_abnormal_energy_balance0.73850104
89MP0006138_congestive_heart_failure0.73670998
90MP0005647_abnormal_sex_gland0.73042654
91MP0009763_increased_sensitivity_to0.72943386
92MP0003329_amyloid_beta_deposits0.72400291
93MP0001984_abnormal_olfaction0.70769144
94MP0003137_abnormal_impulse_conducting0.70524875
95MP0002127_abnormal_cardiovascular_syste0.69233609
96MP0002163_abnormal_gland_morphology0.68276232
97MP0002108_abnormal_muscle_morphology0.67494132
98MP0002693_abnormal_pancreas_physiology0.66986209
99MP0005395_other_phenotype0.66947028
100MP0000747_muscle_weakness0.66470181
101MP0003953_abnormal_hormone_level0.65957076
102MP0009764_decreased_sensitivity_to0.65943948
103MP0005452_abnormal_adipose_tissue0.64886009
104MP0005408_hypopigmentation0.64452862
105MP0002822_catalepsy0.64119759
106MP0004147_increased_porphyrin_level0.62238353
107MP0005551_abnormal_eye_electrophysiolog0.61606628
108MP0003136_yellow_coat_color0.61078722
109MP0002136_abnormal_kidney_physiology0.60763385
110MP0006072_abnormal_retinal_apoptosis0.60366210
111MP0008469_abnormal_protein_level0.59995404
112MP0004085_abnormal_heartbeat0.57455640
113MP0010630_abnormal_cardiac_muscle0.55914808
114MP0009115_abnormal_fat_cell0.53962589
115MP0003690_abnormal_glial_cell0.53659499
116MP0002970_abnormal_white_adipose0.53030735
117MP0000013_abnormal_adipose_tissue0.52909759
118MP0003959_abnormal_lean_body0.52086387
119MP0004484_altered_response_of0.51668066
120MP0002332_abnormal_exercise_endurance0.46054663
121MP0002909_abnormal_adrenal_gland0.46005808
122MP0009780_abnormal_chondrocyte_physiolo0.45613492
123MP0002106_abnormal_muscle_physiology0.43363550
124MP0000538_abnormal_urinary_bladder0.42646044
125MP0009765_abnormal_xenobiotic_induced0.41946028
126MP0008874_decreased_physiological_sensi0.41896961

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)5.66825247
2Nemaline bodies (HP:0003798)5.33008797
3Muscle fiber inclusion bodies (HP:0100299)5.28504288
4Intrahepatic cholestasis (HP:0001406)5.20750657
5Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)5.12408641
6Deep venous thrombosis (HP:0002625)5.09272002
7Xanthomatosis (HP:0000991)4.82193213
8Hypoglycemic coma (HP:0001325)4.81812671
9* Ketosis (HP:0001946)4.72399506
10Hyperglycinuria (HP:0003108)4.69953603
11Hyperammonemia (HP:0001987)4.69434883
12Abnormality of fatty-acid metabolism (HP:0004359)4.55359266
13Abnormality of glycine metabolism (HP:0010895)4.40391921
14Abnormality of serine family amino acid metabolism (HP:0010894)4.40391921
15Abnormality of monocarboxylic acid metabolism (HP:0010996)4.33417635
16Prolonged partial thromboplastin time (HP:0003645)4.33177999
17Exercise-induced muscle cramps (HP:0003710)4.29976039
18Hypobetalipoproteinemia (HP:0003563)4.29142622
19Hyperglycinemia (HP:0002154)4.18643704
20* Ketoacidosis (HP:0001993)4.16466041
21Hyperlipoproteinemia (HP:0010980)4.12770596
22Muscle hypertrophy of the lower extremities (HP:0008968)3.85014262
23Dicarboxylic aciduria (HP:0003215)3.79534743
24Abnormality of dicarboxylic acid metabolism (HP:0010995)3.79534743
25Calf muscle hypertrophy (HP:0008981)3.74859837
26Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.73076710
27Abnormality of glutamine family amino acid metabolism (HP:0010902)3.70903199
28Generalized aminoaciduria (HP:0002909)3.69646148
29Hypolipoproteinemia (HP:0010981)3.65794840
30Hypoalphalipoproteinemia (HP:0003233)3.57266109
31Abnormality of aspartate family amino acid metabolism (HP:0010899)3.56646004
32Cerebral edema (HP:0002181)3.52679260
33Gout (HP:0001997)3.45032387
34Complement deficiency (HP:0004431)3.44613928
35Type 1 muscle fiber predominance (HP:0003803)3.43218400
36Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.37599609
37Epidermoid cyst (HP:0200040)3.36613541
38Metabolic acidosis (HP:0001942)3.29682771
39EMG: myopathic abnormalities (HP:0003458)3.24287105
40Proximal tubulopathy (HP:0000114)3.18518648
41Lethargy (HP:0001254)3.17084593
42Abnormality of sulfur amino acid metabolism (HP:0004339)3.17013155
43Myoglobinuria (HP:0002913)3.16880450
44Abnormality of serum amino acid levels (HP:0003112)3.10826115
45Hepatic necrosis (HP:0002605)3.10182557
46Abnormality of purine metabolism (HP:0004352)3.07504943
47Joint hemorrhage (HP:0005261)3.06564405
48Abnormality of methionine metabolism (HP:0010901)3.03345366
49Abnormality of the common coagulation pathway (HP:0010990)3.00870252
50Abnormality of the calf musculature (HP:0001430)2.99326998
51Delayed CNS myelination (HP:0002188)2.93769678
52Acute encephalopathy (HP:0006846)2.91043081
53Fat malabsorption (HP:0002630)2.88303609
54Abnormality of the intrinsic pathway (HP:0010989)2.76987656
55Abnormality of nucleobase metabolism (HP:0010932)2.76681521
56Bundle branch block (HP:0011710)2.75613576
57Hyperbilirubinemia (HP:0002904)2.70687096
58* Vomiting (HP:0002013)2.68177490
59Abnormality of urine glucose concentration (HP:0011016)2.64929463
60Glycosuria (HP:0003076)2.64929463
61Hyperuricemia (HP:0002149)2.64036572
62Increased purine levels (HP:0004368)2.64036572
63Hyporeflexia of lower limbs (HP:0002600)2.60972024
64Rimmed vacuoles (HP:0003805)2.60251121
65Conjugated hyperbilirubinemia (HP:0002908)2.58486432
66Reduced antithrombin III activity (HP:0001976)2.57448509
67Hypercholesterolemia (HP:0003124)2.50927146
68Subaortic stenosis (HP:0001682)2.50641298
69Abnormality of the left ventricular outflow tract (HP:0011103)2.50641298
70Abnormality of glycolysis (HP:0004366)2.50364467
71Increased serum pyruvate (HP:0003542)2.50364467
72Skin nodule (HP:0200036)2.48012024
73Increased muscle lipid content (HP:0009058)2.46992468
74Hyperalaninemia (HP:0003348)2.45842567
75Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.45842567
76Abnormality of alanine metabolism (HP:0010916)2.45842567
77Asymmetric septal hypertrophy (HP:0001670)2.44888513
78Rhabdomyolysis (HP:0003201)2.44826983
79Hypoglycemic seizures (HP:0002173)2.44356447
80Exercise intolerance (HP:0003546)2.44254053
81Late onset (HP:0003584)2.42960261
82Renal cortical cysts (HP:0000803)2.35066291
83Hyperinsulinemic hypoglycemia (HP:0000825)2.34693333
84Distal arthrogryposis (HP:0005684)2.33248926
85Neck muscle weakness (HP:0000467)2.32544473
86Abnormal mitochondria in muscle tissue (HP:0008316)2.32353858
87Nausea (HP:0002018)2.30510474
88Abnormality of complement system (HP:0005339)2.29488990
89Hepatocellular carcinoma (HP:0001402)2.29104204
90Exercise-induced myalgia (HP:0003738)2.28371414
91Muscle fiber splitting (HP:0003555)2.27037604
92Lipid accumulation in hepatocytes (HP:0006561)2.26668515
93Hepatocellular necrosis (HP:0001404)2.26344570
94Palpitations (HP:0001962)2.25586723
95Lactic acidosis (HP:0003128)2.24861913
96Heart block (HP:0012722)2.21281083
97Sensorimotor neuropathy (HP:0007141)2.21274376
98Abnormal gallbladder morphology (HP:0012437)2.20856769
99Increased serum lactate (HP:0002151)2.20614813
100Cholelithiasis (HP:0001081)2.20381689
101Neonatal onset (HP:0003623)2.19368807
102Acute necrotizing encephalopathy (HP:0006965)2.18370074
103Increased hepatocellular lipid droplets (HP:0006565)2.16234352
104Myopathic facies (HP:0002058)2.16130686
105Dilated cardiomyopathy (HP:0001644)2.15931299
106Sudden death (HP:0001699)2.15670535
107Abnormality of pyrimidine metabolism (HP:0004353)2.15034676
108Irritability (HP:0000737)2.11562514
109Methylmalonic aciduria (HP:0012120)2.11158084
110Alkalosis (HP:0001948)2.10233625
111Respiratory failure (HP:0002878)2.06850481
112Atrioventricular block (HP:0001678)2.05567173
113Abnormal atrioventricular conduction (HP:0005150)2.05358420
114Conjunctival hamartoma (HP:0100780)2.04399551
115Pancreatitis (HP:0001733)2.03931778
116Hyperglycemia (HP:0003074)2.03789955
117Steatorrhea (HP:0002570)2.02889390
118Abnormality of proline metabolism (HP:0010907)2.02528195
119Hydroxyprolinuria (HP:0003080)2.02528195
120Large for gestational age (HP:0001520)2.02488759
121Enlarged kidneys (HP:0000105)2.01049202
122Ragged-red muscle fibers (HP:0003200)1.99984095
123Insulin-resistant diabetes mellitus (HP:0000831)1.98963687
124Vascular calcification (HP:0004934)1.96974518
1253-Methylglutaconic aciduria (HP:0003535)1.96240060
126Ventricular tachycardia (HP:0004756)1.96015190
127Renal Fanconi syndrome (HP:0001994)1.94973511
128Increased intramyocellular lipid droplets (HP:0012240)1.93861730
129Pancreatic islet-cell hyperplasia (HP:0004510)1.93782904
130Pheochromocytoma (HP:0002666)1.93708219
131Increased CSF lactate (HP:0002490)1.91147897
132Cholecystitis (HP:0001082)1.90861908
133Abnormal gallbladder physiology (HP:0012438)1.90861908
134Brushfield spots (HP:0001088)1.89709779
135Progressive macrocephaly (HP:0004481)1.88160320
136Spontaneous abortion (HP:0005268)1.85605302
137Mitochondrial inheritance (HP:0001427)1.83053024
138Malnutrition (HP:0004395)1.82703932

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.90236137
2PDK33.10049973
3PDK43.10049973
4TRIB32.99479478
5SIK12.89733020
6INSRR2.82675749
7WNK42.79321002
8PKN22.73885920
9EIF2AK12.71614571
10EIF2AK32.68103605
11FGFR42.41840311
12ERN12.41771199
13STK162.18661521
14LMTK22.13155195
15WNK32.05408257
16PHKG22.02239148
17PHKG12.02239148
18MAP2K42.00589121
19MYLK1.93060116
20OBSCN1.90866556
21PINK11.79682065
22TTN1.68881783
23NEK11.68475804
24PDK21.60713958
25OXSR11.57684148
26LIMK11.55893977
27MAPKAPK31.54355378
28TIE11.53216548
29MST1R1.51997475
30FLT31.51007769
31PIK3CG1.48221754
32BUB11.45565951
33TRPM71.43310937
34MST41.42442973
35ERBB41.31975373
36ERBB31.29388717
37BMPR1B1.26904718
38PRKAA21.26718962
39PIK3CA1.25607577
40TAOK31.24160363
41NEK91.23230848
42PBK1.21741060
43SCYL21.19549285
44STK38L1.16370429
45MAP3K71.12753111
46MAPK111.09486680
47FRK1.08770446
48CCNB11.07708778
49ZAK1.05961051
50MAP3K91.03447019
51MAP3K121.02819332
52PRKAA10.99448150
53MAPK120.99370792
54PAK30.98896926
55MAP4K20.98534681
56STK390.97930049
57SGK2230.91374797
58SGK4940.91374797
59ABL20.87819014
60MAP3K40.85797397
61DAPK20.84805209
62SGK20.79991678
63GRK70.78958632
64VRK20.76977850
65AKT20.75501765
66SGK30.74648599
67PLK30.74271882
68PRKACG0.73353111
69PTK60.72108237
70TSSK60.72049398
71RIPK10.70367706
72KDR0.70239275
73MUSK0.69031705
74TNIK0.68652883
75MAPKAPK50.68591408
76LATS10.67620723
77CAMK1D0.67427489
78JAK20.67113570
79MARK10.66341373
80BRSK20.64454539
81MAP2K30.64302879
82MAPK40.63856486
83MAP3K60.63731135
84PDPK10.63717563
85AKT30.61760183
86GRK10.61746431
87TESK10.61380595
88PLK40.60814145
89EEF2K0.60342699
90EPHA30.60243270
91NME10.60109673
92MAP2K70.58798685
93MAPK150.58644609
94CSNK1G10.58615624
95MAP2K10.57835740
96CSNK1G30.57810491
97RET0.56869895
98DMPK0.56690926
99NME20.56613941
100PRKG10.56588809
101EPHA40.56507427
102STK240.56343414
103CAMK2G0.55889886
104ACVR1B0.55273216
105PRKCZ0.54999199
106TTK0.54821990
107MAP3K50.53651873
108MAP3K20.53464430
109VRK10.52780596
110FGFR20.52447050
111EIF2AK20.49102789
112PRKD10.48990491
113NTRK30.48880172
114PDK10.48253626
115GSK3A0.45785469
116STK30.45685845
117WEE10.45397958
118CSNK2A20.44631873
119MAP3K30.44255366
120ARAF0.44142070
121MAP2K60.44077620
122PLK10.43874268
123PRKACA0.43318926
124NUAK10.42514516
125DYRK1B0.42154660
126PLK20.41458400
127PKN10.40746145
128TGFBR20.40438880
129JAK10.40066205
130CAMK2A0.39515396
131RPS6KB20.38754893
132ILK0.38743374
133CSNK1G20.38304789
134PNCK0.37611291
135CAMK40.37287815
136CAMK2D0.37230270
137PRKACB0.37064763
138CSNK1E0.36305115
139STK40.35814406
140FGFR30.35549663
141CAMK1G0.34617151
142CDK30.33152283
143PRKCH0.30952536
144CSNK2A10.29540686
145PRKCG0.29492765
146ROCK10.28506537
147CSNK1A1L0.28468639
148EPHB10.28326110
149TYK20.28240361
150PRKCQ0.27172365
151IGF1R0.26879092
152FER0.25287559
153PRKCE0.23711828
154MET0.23182263
155STK380.20351950
156GRK60.20346993
157SGK10.20014160

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.47438848
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.18413191
3* Fatty acid degradation_Homo sapiens_hsa000713.16373930
4* Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.13925309
5* Propanoate metabolism_Homo sapiens_hsa006403.05564149
6* Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.90191559
7Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.81478877
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.72327275
9Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.70725231
10* Butanoate metabolism_Homo sapiens_hsa006502.68683641
112-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.66484528
12Nitrogen metabolism_Homo sapiens_hsa009102.63872513
13* Tryptophan metabolism_Homo sapiens_hsa003802.49609173
14Arginine biosynthesis_Homo sapiens_hsa002202.49102095
15* Fatty acid metabolism_Homo sapiens_hsa012122.45354535
16Peroxisome_Homo sapiens_hsa041462.21659275
17Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.13217867
18PPAR signaling pathway_Homo sapiens_hsa033202.09602094
19* Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.02016209
20* Pyruvate metabolism_Homo sapiens_hsa006201.99040051
21Pentose and glucuronate interconversions_Homo sapiens_hsa000401.94744763
22beta-Alanine metabolism_Homo sapiens_hsa004101.88678201
23Complement and coagulation cascades_Homo sapiens_hsa046101.82158874
24Fatty acid elongation_Homo sapiens_hsa000621.81506958
25* Carbon metabolism_Homo sapiens_hsa012001.74047128
26Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.64333756
27Sulfur metabolism_Homo sapiens_hsa009201.59325922
28Histidine metabolism_Homo sapiens_hsa003401.48946987
29Phenylalanine metabolism_Homo sapiens_hsa003601.45222566
30Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.44763412
31Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.44723290
32Chemical carcinogenesis_Homo sapiens_hsa052041.39703980
33Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.37503985
34Steroid hormone biosynthesis_Homo sapiens_hsa001401.35296395
35Starch and sucrose metabolism_Homo sapiens_hsa005001.31931783
36Bile secretion_Homo sapiens_hsa049761.28409818
37Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.27346791
38Protein export_Homo sapiens_hsa030601.27094342
39Tyrosine metabolism_Homo sapiens_hsa003501.26753973
40Biosynthesis of amino acids_Homo sapiens_hsa012301.26349610
41Selenocompound metabolism_Homo sapiens_hsa004501.22454337
42Drug metabolism - other enzymes_Homo sapiens_hsa009831.22299672
43Retinol metabolism_Homo sapiens_hsa008301.18579849
44Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.12059930
45Cysteine and methionine metabolism_Homo sapiens_hsa002701.11524290
46Fat digestion and absorption_Homo sapiens_hsa049751.10247208
47Caffeine metabolism_Homo sapiens_hsa002321.06654802
48Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.05297459
49Proteasome_Homo sapiens_hsa030501.04860237
50Arginine and proline metabolism_Homo sapiens_hsa003301.01483546
51Cyanoamino acid metabolism_Homo sapiens_hsa004601.00842450
52Folate biosynthesis_Homo sapiens_hsa007900.99524415
53Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.96733604
54Oxidative phosphorylation_Homo sapiens_hsa001900.92622629
55Staphylococcus aureus infection_Homo sapiens_hsa051500.91923618
56Maturity onset diabetes of the young_Homo sapiens_hsa049500.91272762
57ABC transporters_Homo sapiens_hsa020100.85779899
58Glycerolipid metabolism_Homo sapiens_hsa005610.83398511
59Parkinsons disease_Homo sapiens_hsa050120.82330233
60Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.79885171
61* Lysine degradation_Homo sapiens_hsa003100.76552867
62Steroid biosynthesis_Homo sapiens_hsa001000.75718268
63Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.75533461
64Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.73351246
65Fatty acid biosynthesis_Homo sapiens_hsa000610.72182292
66Vitamin digestion and absorption_Homo sapiens_hsa049770.71765509
67Sulfur relay system_Homo sapiens_hsa041220.66698098
68Circadian rhythm_Homo sapiens_hsa047100.65087166
69Glutathione metabolism_Homo sapiens_hsa004800.62931713
70* Metabolic pathways_Homo sapiens_hsa011000.56923856
71Alzheimers disease_Homo sapiens_hsa050100.56354358
72Vitamin B6 metabolism_Homo sapiens_hsa007500.53403701
73Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.52800865
74Pentose phosphate pathway_Homo sapiens_hsa000300.51078182
75RNA polymerase_Homo sapiens_hsa030200.45774582
76Adipocytokine signaling pathway_Homo sapiens_hsa049200.44966706
77Purine metabolism_Homo sapiens_hsa002300.42833254
78Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.42717823
79Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.42440828
80Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.41421075
81Cardiac muscle contraction_Homo sapiens_hsa042600.41230721
82Insulin resistance_Homo sapiens_hsa049310.41042243
83Glucagon signaling pathway_Homo sapiens_hsa049220.39847016
84Fructose and mannose metabolism_Homo sapiens_hsa000510.35989155
85Pyrimidine metabolism_Homo sapiens_hsa002400.33423491
86Galactose metabolism_Homo sapiens_hsa000520.32851154
87Huntingtons disease_Homo sapiens_hsa050160.30636132
88AMPK signaling pathway_Homo sapiens_hsa041520.27303713
89Nucleotide excision repair_Homo sapiens_hsa034200.25143900
90alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.23969315
91Insulin secretion_Homo sapiens_hsa049110.23128791
92Homologous recombination_Homo sapiens_hsa034400.22434523
93Mineral absorption_Homo sapiens_hsa049780.20624575
94Non-homologous end-joining_Homo sapiens_hsa034500.18272774
95Insulin signaling pathway_Homo sapiens_hsa049100.16986385
96Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.14716600
97One carbon pool by folate_Homo sapiens_hsa006700.14029957
98Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.10214488
99Linoleic acid metabolism_Homo sapiens_hsa005910.08947423
100Glycerophospholipid metabolism_Homo sapiens_hsa005640.08502624
101Prion diseases_Homo sapiens_hsa050200.07358069
102* Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.03811734
103Ovarian steroidogenesis_Homo sapiens_hsa049130.01544704
104Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1278601
105Collecting duct acid secretion_Homo sapiens_hsa04966-0.1192504
106Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.1156946
107Renin-angiotensin system_Homo sapiens_hsa04614-0.1105882
108Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1100381
109Regulation of autophagy_Homo sapiens_hsa04140-0.1088356
110Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1000410
111Thyroid hormone synthesis_Homo sapiens_hsa04918-0.0925238
112Protein digestion and absorption_Homo sapiens_hsa04974-0.0771913
113Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.0600744
114Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410-0.0398653
115Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923-0.0395634
116Dilated cardiomyopathy_Homo sapiens_hsa05414-0.0286313

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