ACAT2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The product of this gene is an enzyme involved in lipid metabolism, and it encodes cytosolic acetoacetyl-CoA thiolase. This gene shows complementary overlapping with the 3-prime region of the TCP1 gene in both mouse and human. These genes are encoded on opposite strands of DNA, as well as in opposite transcriptional orientation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cholesterol biosynthetic process (GO:0006695)8.34270317
2sterol biosynthetic process (GO:0016126)7.34909334
3fatty acid elongation (GO:0030497)6.90881032
4pyrimidine nucleobase catabolic process (GO:0006208)6.32601821
5isoprenoid biosynthetic process (GO:0008299)5.65999625
6long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)5.29308353
7fatty-acyl-CoA biosynthetic process (GO:0046949)5.01409953
8nucleobase catabolic process (GO:0046113)4.77233720
9chromatin remodeling at centromere (GO:0031055)4.70037971
10long-chain fatty-acyl-CoA metabolic process (GO:0035336)4.66104681
11erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.62575942
12L-phenylalanine catabolic process (GO:0006559)4.62575942
13CENP-A containing nucleosome assembly (GO:0034080)4.51940863
14thioester biosynthetic process (GO:0035384)4.47134640
15acyl-CoA biosynthetic process (GO:0071616)4.47134640
16alpha-linolenic acid metabolic process (GO:0036109)4.45717627
17acetyl-CoA metabolic process (GO:0006084)4.43832367
18glyoxylate metabolic process (GO:0046487)4.40561734
19fatty-acyl-CoA metabolic process (GO:0035337)4.40391780
20erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.36547933
21L-phenylalanine metabolic process (GO:0006558)4.36547933
22establishment of integrated proviral latency (GO:0075713)4.36470116
23L-serine metabolic process (GO:0006563)4.32621833
24axon ensheathment in central nervous system (GO:0032291)4.25101450
25central nervous system myelination (GO:0022010)4.25101450
26proteasome assembly (GO:0043248)4.16112933
27serine family amino acid biosynthetic process (GO:0009070)4.11000762
28very long-chain fatty acid metabolic process (GO:0000038)4.02337125
29histone exchange (GO:0043486)3.93550001
30DNA strand elongation involved in DNA replication (GO:0006271)3.86776914
31coenzyme catabolic process (GO:0009109)3.84229746
32thioester metabolic process (GO:0035383)3.83646066
33acyl-CoA metabolic process (GO:0006637)3.83646066
34DNA double-strand break processing (GO:0000729)3.77210502
35cellular ketone body metabolic process (GO:0046950)3.73732510
36DNA replication checkpoint (GO:0000076)3.72660098
37DNA replication-independent nucleosome assembly (GO:0006336)3.72619330
38DNA replication-independent nucleosome organization (GO:0034724)3.72619330
39steroid biosynthetic process (GO:0006694)3.70742185
40establishment of mitochondrion localization (GO:0051654)3.68204332
41coenzyme A metabolic process (GO:0015936)3.66130924
42DNA strand elongation (GO:0022616)3.64467032
43purine nucleobase biosynthetic process (GO:0009113)3.63067438
44negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.62055164
45mitotic metaphase plate congression (GO:0007080)3.60598854
46aldehyde catabolic process (GO:0046185)3.59915104
47aromatic amino acid family catabolic process (GO:0009074)3.59848289
48telomere maintenance via semi-conservative replication (GO:0032201)3.56313568
49IMP biosynthetic process (GO:0006188)3.53163261
50DNA replication-dependent nucleosome assembly (GO:0006335)3.51321985
51DNA replication-dependent nucleosome organization (GO:0034723)3.51321985
52cholesterol metabolic process (GO:0008203)3.50220528
53protein localization to kinetochore (GO:0034501)3.49016290
54regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.48985398
55establishment of protein localization to mitochondrial membrane (GO:0090151)3.48787324
56establishment of viral latency (GO:0019043)3.45640568
57DNA damage response, detection of DNA damage (GO:0042769)3.43705288
58mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.39599461
59bile acid biosynthetic process (GO:0006699)3.39256817
60anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.38113081
61nucleobase biosynthetic process (GO:0046112)3.35608797
62ketone body metabolic process (GO:1902224)3.33520528
63DNA ligation (GO:0006266)3.31445325
64negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.28423568
65negative regulation of ligase activity (GO:0051352)3.28423568
66ethanol oxidation (GO:0006069)3.25984666
67positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.25682628
68cullin deneddylation (GO:0010388)3.25621499
69sterol metabolic process (GO:0016125)3.25071188
70metaphase plate congression (GO:0051310)3.23220524
71glycine metabolic process (GO:0006544)3.23201648
72mitotic sister chromatid segregation (GO:0000070)3.21175134
73serine family amino acid metabolic process (GO:0009069)3.19280301
74spindle checkpoint (GO:0031577)3.15785312
75kinetochore organization (GO:0051383)3.11589461
76tyrosine metabolic process (GO:0006570)3.11345909
77double-strand break repair via nonhomologous end joining (GO:0006303)3.08478160
78non-recombinational repair (GO:0000726)3.08478160
79exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.06927415
80heme transport (GO:0015886)3.06470606
81negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.06318994
82negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.06318994
83negative regulation of mitotic sister chromatid segregation (GO:0033048)3.06318994
84negative regulation of mitotic sister chromatid separation (GO:2000816)3.06318994
85negative regulation of sister chromatid segregation (GO:0033046)3.06318994
86somatic diversification of immune receptors via somatic mutation (GO:0002566)3.05911305
87somatic hypermutation of immunoglobulin genes (GO:0016446)3.05911305
88long-chain fatty acid biosynthetic process (GO:0042759)3.05339153
89mitotic spindle checkpoint (GO:0071174)3.05199326
90nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.05011790
91negative regulation of chromosome segregation (GO:0051985)3.04988504
92mitotic recombination (GO:0006312)3.03092536
93regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.02531494
94telomere maintenance via recombination (GO:0000722)3.01640503
95kinetochore assembly (GO:0051382)3.00970368
96triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.00282826
97sister chromatid segregation (GO:0000819)3.00211216
98terpenoid biosynthetic process (GO:0016114)2.99859458
99negative regulation of microtubule polymerization (GO:0031115)2.97955178
100regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.97241867
101regulation of mitotic spindle checkpoint (GO:1903504)2.97241867
102alcohol biosynthetic process (GO:0046165)2.96692989
103regulation of cellular amino acid metabolic process (GO:0006521)2.96335728
104IMP metabolic process (GO:0046040)2.95842829
105spliceosomal snRNP assembly (GO:0000387)2.95437111
106negative regulation of DNA-dependent DNA replication (GO:2000104)2.94745627
107protein neddylation (GO:0045116)2.94694287
108sulfur amino acid catabolic process (GO:0000098)2.94654521
109DNA catabolic process, exonucleolytic (GO:0000738)2.94021806
110triglyceride biosynthetic process (GO:0019432)2.93058752
111water-soluble vitamin biosynthetic process (GO:0042364)2.91307760
112ATP-dependent chromatin remodeling (GO:0043044)2.91060445
113replication fork processing (GO:0031297)2.90555005
114ATP synthesis coupled proton transport (GO:0015986)2.89800614
115energy coupled proton transport, down electrochemical gradient (GO:0015985)2.89800614
116nucleotide-excision repair, DNA gap filling (GO:0006297)2.89325945
117cell migration in hindbrain (GO:0021535)2.88541368
118protein deneddylation (GO:0000338)2.87863542
119cofactor catabolic process (GO:0051187)2.87657158
120arginine catabolic process (GO:0006527)2.87420811
121ribosome assembly (GO:0042255)2.86289985
122coenzyme A biosynthetic process (GO:0015937)2.84769390
123DNA strand renaturation (GO:0000733)2.83534132
124serine family amino acid catabolic process (GO:0009071)2.81314782
125regulation of mitochondrial translation (GO:0070129)2.80490139
126regulation of mitotic metaphase/anaphase transition (GO:0030071)2.80438442
127regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.80438442
128mitotic spindle assembly checkpoint (GO:0007094)2.80418697
129negative regulation of fibrinolysis (GO:0051918)2.80262892
130positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.79269184
131neutral lipid biosynthetic process (GO:0046460)2.78329071
132acylglycerol biosynthetic process (GO:0046463)2.78329071
133protein localization to chromosome, centromeric region (GO:0071459)2.78012086
134regulation of helicase activity (GO:0051095)2.77865985
135cysteine metabolic process (GO:0006534)2.77187415
136regulation of cholesterol biosynthetic process (GO:0045540)2.76660502
137signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.76461241
138signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.76461241
139signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.76461241
140regulation of chromosome segregation (GO:0051983)2.76438323
141spindle assembly checkpoint (GO:0071173)2.75980307
142DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.74772977
143regulation of centriole replication (GO:0046599)2.74756847
144negative regulation of DNA recombination (GO:0045910)2.74239387
145arginine metabolic process (GO:0006525)2.73185517
146aromatic amino acid family metabolic process (GO:0009072)2.73014470
147telomere maintenance via telomere lengthening (GO:0010833)2.72794956
148signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.71846011
149intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.71846011
150substantia nigra development (GO:0021762)2.71155777
151cellular response to cholesterol (GO:0071397)2.70126043
152regulation of sister chromatid segregation (GO:0033045)2.68918542
153regulation of mitotic sister chromatid separation (GO:0010965)2.68918542
154regulation of mitotic sister chromatid segregation (GO:0033047)2.68918542
155signal transduction involved in cell cycle checkpoint (GO:0072395)2.68462410
156response to methylmercury (GO:0051597)2.68204253
157chaperone-mediated protein transport (GO:0072321)2.67808610
158myelination (GO:0042552)2.67633000
159signal transduction involved in DNA integrity checkpoint (GO:0072401)2.67566241
160bile acid metabolic process (GO:0008206)2.67149671
161axon ensheathment (GO:0008366)2.66415314
162ensheathment of neurons (GO:0007272)2.66415314
163mitochondrion transport along microtubule (GO:0047497)2.64826892
164establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.64826892
165tryptophan catabolic process (GO:0006569)2.63037226
166indole-containing compound catabolic process (GO:0042436)2.63037226
167indolalkylamine catabolic process (GO:0046218)2.63037226
168alpha-amino acid catabolic process (GO:1901606)2.62881594
169regulation of collateral sprouting (GO:0048670)2.62518227
170NADPH regeneration (GO:0006740)2.62131421
171kynurenine metabolic process (GO:0070189)2.61337494
172plasma lipoprotein particle clearance (GO:0034381)2.60458555
173negative regulation of axon extension involved in axon guidance (GO:0048843)2.59966487
174cellular aldehyde metabolic process (GO:0006081)2.59296755
175peroxisome fission (GO:0016559)2.55804783
176regulation of fibrinolysis (GO:0051917)2.53721265
177limb bud formation (GO:0060174)2.53144198
178ethanol metabolic process (GO:0006067)2.52690142
179detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.52523602
180detection of temperature stimulus involved in sensory perception (GO:0050961)2.52523602
181short-chain fatty acid metabolic process (GO:0046459)2.51026455
182cellular amino acid catabolic process (GO:0009063)2.49036126
183tryptophan metabolic process (GO:0006568)2.46923087
184regulation of cholesterol metabolic process (GO:0090181)2.45369362
185high-density lipoprotein particle remodeling (GO:0034375)2.42484417
186urea metabolic process (GO:0019627)2.42387177
187urea cycle (GO:0000050)2.42387177
188very-low-density lipoprotein particle assembly (GO:0034379)2.42330669
189purine nucleoside bisphosphate metabolic process (GO:0034032)2.42328386
190ribonucleoside bisphosphate metabolic process (GO:0033875)2.42328386

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.34481235
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.33711029
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.93604142
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.83373092
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.80232733
6* PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.09729989
7FOXM1_23109430_ChIP-Seq_U2OS_Human2.99289843
8NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.95663686
9MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.88641641
10CREB1_15753290_ChIP-ChIP_HEK293T_Human2.87961768
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.74042262
12RXR_22158963_ChIP-Seq_LIVER_Mouse2.54827783
13HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.52986324
14ELK1_19687146_ChIP-ChIP_HELA_Human2.44329482
15CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.42389388
16RBPJ_22232070_ChIP-Seq_NCS_Mouse2.27285551
17* CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.13821432
18KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.04715517
19PPARA_22158963_ChIP-Seq_LIVER_Mouse1.95842904
20EGR1_23403033_ChIP-Seq_LIVER_Mouse1.95615084
21HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.93484113
22MYC_18555785_ChIP-Seq_MESCs_Mouse1.91731819
23PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.89827724
24NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.85171734
25PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.83576958
26ZNF274_21170338_ChIP-Seq_K562_Hela1.83308814
27VDR_23849224_ChIP-Seq_CD4+_Human1.79653354
28* CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.78522898
29FOXP3_21729870_ChIP-Seq_TREG_Human1.78223337
30YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.76075619
31E2F1_21310950_ChIP-Seq_MCF-7_Human1.75039650
32THAP11_20581084_ChIP-Seq_MESCs_Mouse1.72491249
33GABP_17652178_ChIP-ChIP_JURKAT_Human1.71906206
34EST1_17652178_ChIP-ChIP_JURKAT_Human1.69694714
35LXR_22158963_ChIP-Seq_LIVER_Mouse1.69004168
36KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.68590827
37XRN2_22483619_ChIP-Seq_HELA_Human1.67553073
38HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.67055364
39* GABP_19822575_ChIP-Seq_HepG2_Human1.65980878
40PADI4_21655091_ChIP-ChIP_MCF-7_Human1.65790187
41* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.65053011
42TAF15_26573619_Chip-Seq_HEK293_Human1.63680353
43* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.63315222
44SOX2_18555785_ChIP-Seq_MESCs_Mouse1.62714063
45JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.62577681
46FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.60142292
47CLOCK_20551151_ChIP-Seq_293T_Human1.59418864
48ETS1_20019798_ChIP-Seq_JURKAT_Human1.54790423
49E2F1_18555785_ChIP-Seq_MESCs_Mouse1.51390854
50SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.50063008
51EWS_26573619_Chip-Seq_HEK293_Human1.49492120
52SRF_21415370_ChIP-Seq_HL-1_Mouse1.49131538
53WT1_19549856_ChIP-ChIP_CCG9911_Human1.48888354
54IGF1R_20145208_ChIP-Seq_DFB_Human1.47086177
55SOX17_20123909_ChIP-Seq_XEN_Mouse1.41979089
56CBX2_27304074_Chip-Seq_ESCs_Mouse1.41550445
57* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.40248105
58IRF1_19129219_ChIP-ChIP_H3396_Human1.39480096
59EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.37735630
60* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.36737214
61POU5F1_16153702_ChIP-ChIP_HESCs_Human1.35954082
62* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.34209113
63MYC_19030024_ChIP-ChIP_MESCs_Mouse1.34187388
64HOXB4_20404135_ChIP-ChIP_EML_Mouse1.33804417
65VDR_22108803_ChIP-Seq_LS180_Human1.33593639
66EZH2_27304074_Chip-Seq_ESCs_Mouse1.31634231
67* MYC_19079543_ChIP-ChIP_MESCs_Mouse1.30625345
68PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.30086604
69FUS_26573619_Chip-Seq_HEK293_Human1.28680039
70NANOG_18555785_ChIP-Seq_MESCs_Mouse1.28275722
71POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.27245359
72SALL1_21062744_ChIP-ChIP_HESCs_Human1.26869628
73* AR_21909140_ChIP-Seq_LNCAP_Human1.23159208
74POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.22718302
75POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.22336039
76MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.22137240
77SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.20131768
78SOX2_18692474_ChIP-Seq_MEFs_Mouse1.17020505
79ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.16963301
80NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.16025982
81SOX2_16153702_ChIP-ChIP_HESCs_Human1.15247968
82SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.15054759
83EED_16625203_ChIP-ChIP_MESCs_Mouse1.14964517
84PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.14372582
85ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.13915136
86HTT_18923047_ChIP-ChIP_STHdh_Human1.13506107
87RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.11763668
88DCP1A_22483619_ChIP-Seq_HELA_Human1.11566754
89MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.10494171
90ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.10451547
91OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10117372
92E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.09518301
93ESR1_15608294_ChIP-ChIP_MCF-7_Human1.09069576
94CTBP2_25329375_ChIP-Seq_LNCAP_Human1.08893657
95GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.08261157
96TCF3_18692474_ChIP-Seq_MEFs_Mouse1.07714964
97PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.07589807
98TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.07009548
99FLI1_27457419_Chip-Seq_LIVER_Mouse1.06580766
100GBX2_23144817_ChIP-Seq_PC3_Human1.05953518
101DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.05686603
102BMI1_23680149_ChIP-Seq_NPCS_Mouse1.05212015
103AR_21572438_ChIP-Seq_LNCaP_Human1.03833445
104CTBP1_25329375_ChIP-Seq_LNCAP_Human1.02453231
105FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.01253418
106NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.01140466
107ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.00809054
108CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.00565144
109ZNF263_19887448_ChIP-Seq_K562_Human0.98778617
110MYCN_18555785_ChIP-Seq_MESCs_Mouse0.98718863
111HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.97947098
112YY1_21170310_ChIP-Seq_MESCs_Mouse0.96526218
113OCT4_18692474_ChIP-Seq_MEFs_Mouse0.95098415
114P300_19829295_ChIP-Seq_ESCs_Human0.94107390
115KDM5A_27292631_Chip-Seq_BREAST_Human0.91820124
116SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.91586617
117ELF1_17652178_ChIP-ChIP_JURKAT_Human0.90681084
118TTF2_22483619_ChIP-Seq_HELA_Human0.90532748
119ERG_21242973_ChIP-ChIP_JURKAT_Human0.89464940
120ZFP281_18757296_ChIP-ChIP_E14_Mouse0.89395886
121* NANOG_16153702_ChIP-ChIP_HESCs_Human0.89037064
122GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.88824347
123POU3F2_20337985_ChIP-ChIP_501MEL_Human0.88764117
124* REST_19997604_ChIP-ChIP_NEURONS_Mouse0.88133141
125TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.87846186
126EOMES_21245162_ChIP-Seq_HESCs_Human0.87092102
127KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.86892923
128NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.85336865
129NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.85227988
130MYC_18940864_ChIP-ChIP_HL60_Human0.85012444
131TP63_19390658_ChIP-ChIP_HaCaT_Human0.84713139
132ZFX_18555785_ChIP-Seq_MESCs_Mouse0.84132158
133FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.84023456
134FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.83961448
135CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.83652289
136OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.83220955
137ZFP57_27257070_Chip-Seq_ESCs_Mouse0.82278378
138STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.82145360
139PCGF2_27294783_Chip-Seq_ESCs_Mouse0.81788681
140SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.81463196
141CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.78018691
142CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.77687316
143MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.77177467
144CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.74316672
145NANOG_21062744_ChIP-ChIP_HESCs_Human0.73636631

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.19240773
2MP0003806_abnormal_nucleotide_metabolis4.13962615
3MP0010094_abnormal_chromosome_stability3.75121464
4MP0005360_urolithiasis3.72796837
5MP0008058_abnormal_DNA_repair3.37630752
6MP0003693_abnormal_embryo_hatching3.30627343
7MP0003111_abnormal_nucleus_morphology2.97829991
8MP0004957_abnormal_blastocyst_morpholog2.97481762
9MP0005085_abnormal_gallbladder_physiolo2.91394657
10MP0001529_abnormal_vocalization2.79865466
11MP0006292_abnormal_olfactory_placode2.77634378
12MP0000778_abnormal_nervous_system2.57929716
13MP0008877_abnormal_DNA_methylation2.44963394
14MP0003121_genomic_imprinting2.44229620
15MP0005365_abnormal_bile_salt2.43858842
16MP0003077_abnormal_cell_cycle2.34583678
17MP0010030_abnormal_orbit_morphology2.24402514
18MP0003941_abnormal_skin_development2.24099712
19MP0008875_abnormal_xenobiotic_pharmacok2.23924206
20MP0005083_abnormal_biliary_tract2.23862110
21MP0001293_anophthalmia2.17309833
22MP0003011_delayed_dark_adaptation2.00431443
23MP0009053_abnormal_anal_canal1.94635056
24MP0008007_abnormal_cellular_replicative1.93247325
25MP0009379_abnormal_foot_pigmentation1.90434791
26MP0003329_amyloid_beta_deposits1.88754051
27MP0000537_abnormal_urethra_morphology1.88358496
28MP0005499_abnormal_olfactory_system1.86451049
29MP0005394_taste/olfaction_phenotype1.86451049
30MP0008057_abnormal_DNA_replication1.81616439
31MP0004270_analgesia1.79120322
32MP0006276_abnormal_autonomic_nervous1.78951406
33MP0003567_abnormal_fetal_cardiomyocyte1.68217905
34MP0003123_paternal_imprinting1.62808894
35MP0003787_abnormal_imprinting1.60324151
36MP0005332_abnormal_amino_acid1.55125197
37MP0000920_abnormal_myelination1.54298292
38MP0010329_abnormal_lipoprotein_level1.52797737
39MP0006072_abnormal_retinal_apoptosis1.48906252
40MP0002751_abnormal_autonomic_nervous1.48829166
41MP0004142_abnormal_muscle_tone1.47828741
42MP0003718_maternal_effect1.47216168
43MP0001905_abnormal_dopamine_level1.46648541
44MP0003880_abnormal_central_pattern1.42711476
45MP0001730_embryonic_growth_arrest1.38595044
46MP0001984_abnormal_olfaction1.37145252
47MP0000566_synostosis1.35695972
48MP0003942_abnormal_urinary_system1.35608852
49MP0003890_abnormal_embryonic-extraembry1.35026873
50MP0001188_hyperpigmentation1.33015783
51MP0003937_abnormal_limbs/digits/tail_de1.31646758
52MP0001286_abnormal_eye_development1.28055324
53MP0008932_abnormal_embryonic_tissue1.26671709
54MP0003786_premature_aging1.25890779
55MP0003632_abnormal_nervous_system1.24064298
56MP0009840_abnormal_foam_cell1.20547827
57MP0002653_abnormal_ependyma_morphology1.20493106
58MP0009250_abnormal_appendicular_skeleto1.19559253
59MP0003938_abnormal_ear_development1.18513496
60MP0003385_abnormal_body_wall1.18444472
61MP0002085_abnormal_embryonic_tissue1.18303932
62MP0009697_abnormal_copulation1.17729925
63MP0003861_abnormal_nervous_system1.17676901
64MP0003195_calcinosis1.17124999
65MP0002084_abnormal_developmental_patter1.17070073
66MP0000955_abnormal_spinal_cord1.16317791
67MP0002734_abnormal_mechanical_nocicepti1.15712403
68MP0003315_abnormal_perineum_morphology1.15686842
69MP0000647_abnormal_sebaceous_gland1.15153124
70MP0002733_abnormal_thermal_nociception1.15057406
71MP0003122_maternal_imprinting1.13834351
72MP0002282_abnormal_trachea_morphology1.13386980
73MP0001672_abnormal_embryogenesis/_devel1.13386531
74MP0005380_embryogenesis_phenotype1.13386531
75MP0005408_hypopigmentation1.11074770
76MP0001697_abnormal_embryo_size1.10571536
77MP0002938_white_spotting1.08932272
78MP0005253_abnormal_eye_physiology1.08473780
79MP0002118_abnormal_lipid_homeostasis1.08062004
80MP0003119_abnormal_digestive_system1.07489112
81MP0001968_abnormal_touch/_nociception1.07140424
82MP0004133_heterotaxia1.06130347
83MP0002184_abnormal_innervation1.05755496
84MP0005084_abnormal_gallbladder_morpholo1.05388177
85MP0002736_abnormal_nociception_after1.03977595
86MP0000350_abnormal_cell_proliferation1.02748237
87MP0000372_irregular_coat_pigmentation1.01997104
88MP0002210_abnormal_sex_determination1.00544712
89MP0009672_abnormal_birth_weight1.00299380
90MP0009703_decreased_birth_body0.98704110
91MP0002735_abnormal_chemical_nociception0.98541520
92MP0002152_abnormal_brain_morphology0.96282932
93MP0001929_abnormal_gametogenesis0.95359685
94MP0002882_abnormal_neuron_morphology0.94640782
95MP0004858_abnormal_nervous_system0.94470193
96MP0004197_abnormal_fetal_growth/weight/0.93582339
97MP0002752_abnormal_somatic_nervous0.93401638
98MP0004742_abnormal_vestibular_system0.93205890
99MP0005391_vision/eye_phenotype0.93169454
100MP0002080_prenatal_lethality0.92953166
101MP0002233_abnormal_nose_morphology0.92584529
102MP0002102_abnormal_ear_morphology0.91996587
103MP0000462_abnormal_digestive_system0.91937652
104MP0003755_abnormal_palate_morphology0.91445936
105MP0000534_abnormal_ureter_morphology0.90804469
106MP0000049_abnormal_middle_ear0.90710341
107MP0003634_abnormal_glial_cell0.90649578
108MP0005248_abnormal_Harderian_gland0.90252367
109MP0002234_abnormal_pharynx_morphology0.88471575
110MP0002090_abnormal_vision0.87824485
111MP0001340_abnormal_eyelid_morphology0.87631815
112MP0003868_abnormal_feces_composition0.86027772
113MP0006036_abnormal_mitochondrial_physio0.85783632
114MP0002249_abnormal_larynx_morphology0.85705546
115MP0003984_embryonic_growth_retardation0.85693218
116MP0000604_amyloidosis0.85528063
117MP0002111_abnormal_tail_morphology0.85432915
118MP0001177_atelectasis0.85414869
119MP0001299_abnormal_eye_distance/0.85250624
120MP0001145_abnormal_male_reproductive0.84490740
121MP0000653_abnormal_sex_gland0.84096691
122MP0006035_abnormal_mitochondrial_morpho0.84025390
123MP0002088_abnormal_embryonic_growth/wei0.83321899
124MP0005551_abnormal_eye_electrophysiolog0.83256030
125MP0003186_abnormal_redox_activity0.82659886
126MP0005423_abnormal_somatic_nervous0.82345999
127MP0008789_abnormal_olfactory_epithelium0.81987191
128MP0004147_increased_porphyrin_level0.80326321
129MP0001666_abnormal_nutrient_absorption0.78611530
130MP0005386_behavior/neurological_phenoty0.78495781
131MP0004924_abnormal_behavior0.78495781
132MP0004019_abnormal_vitamin_homeostasis0.78490111
133MP0004134_abnormal_chest_morphology0.77479384
134MP0001764_abnormal_homeostasis0.76717678
135MP0003252_abnormal_bile_duct0.74910589
136MP0001324_abnormal_eye_pigmentation0.74829762
137MP0002092_abnormal_eye_morphology0.74504080
138MP0000631_abnormal_neuroendocrine_gland0.74432188
139MP0003698_abnormal_male_reproductive0.73146933
140MP0003690_abnormal_glial_cell0.72207978
141MP0002066_abnormal_motor_capabilities/c0.72195713
142MP0005584_abnormal_enzyme/coenzyme_acti0.72108430
143MP0001440_abnormal_grooming_behavior0.71112114
144MP0003136_yellow_coat_color0.70909191
145MP0004811_abnormal_neuron_physiology0.70214287
146MP0001486_abnormal_startle_reflex0.69664184
147MP0001485_abnormal_pinna_reflex0.69100446
148MP0002254_reproductive_system_inflammat0.69026275
149MP0002063_abnormal_learning/memory/cond0.68935974
150MP0005187_abnormal_penis_morphology0.68919667
151MP0001661_extended_life_span0.68914300
152MP0000358_abnormal_cell_content/0.68804471
153MP0005195_abnormal_posterior_eye0.68103596
154MP0001119_abnormal_female_reproductive0.67975395
155MP0002697_abnormal_eye_size0.67091904
156MP0000313_abnormal_cell_death0.64925165

Predicted human phenotypes

RankGene SetZ-score
1Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.12411784
2Degeneration of the lateral corticospinal tracts (HP:0002314)4.12411784
3Abnormality of the corticospinal tract (HP:0002492)3.99427155
4Parakeratosis (HP:0001036)3.93615211
5Hypobetalipoproteinemia (HP:0003563)3.85394325
6Intrahepatic cholestasis (HP:0001406)3.62610642
7* Increased serum pyruvate (HP:0003542)3.55489740
8* Abnormality of glycolysis (HP:0004366)3.55489740
9Colon cancer (HP:0003003)3.45238205
10Insidious onset (HP:0003587)3.42061488
11Termporal pattern (HP:0011008)3.42061488
12Deep venous thrombosis (HP:0002625)3.40953523
13Abnormality of aromatic amino acid family metabolism (HP:0004338)3.40216371
14Abnormal lung lobation (HP:0002101)3.25121813
15Hypoplastic pelvis (HP:0008839)3.21783040
16Xanthomatosis (HP:0000991)3.11986443
17Meckel diverticulum (HP:0002245)3.07355565
18Hyperglycinemia (HP:0002154)3.04292646
19Chromosomal breakage induced by crosslinking agents (HP:0003221)3.00047469
20Abnormality of serine family amino acid metabolism (HP:0010894)2.99406917
21Abnormality of glycine metabolism (HP:0010895)2.99406917
22Abnormality of the ileum (HP:0001549)2.94248237
23Chromsome breakage (HP:0040012)2.78588501
24Cerebral hypomyelination (HP:0006808)2.70645519
25Morphological abnormality of the pyramidal tract (HP:0002062)2.70339327
26Neurofibrillary tangles (HP:0002185)2.68176643
27Epidermoid cyst (HP:0200040)2.66227696
28Aplasia/Hypoplasia of the uvula (HP:0010293)2.63768306
29Abnormality of monocarboxylic acid metabolism (HP:0010996)2.63076665
30Septo-optic dysplasia (HP:0100842)2.61554362
31Birth length less than 3rd percentile (HP:0003561)2.60396595
32Pheochromocytoma (HP:0002666)2.59573532
33Coronal craniosynostosis (HP:0004440)2.56965964
34Myelomeningocele (HP:0002475)2.55715205
35Abnormality of chromosome stability (HP:0003220)2.54042121
36Bifid tongue (HP:0010297)2.53127629
37Multiple enchondromatosis (HP:0005701)2.50010955
38Poor suck (HP:0002033)2.44587379
39Leukodystrophy (HP:0002415)2.43443773
40Sensory axonal neuropathy (HP:0003390)2.43050579
41Hyperlipoproteinemia (HP:0010980)2.42848915
42Partial agenesis of the corpus callosum (HP:0001338)2.40753897
43Ependymoma (HP:0002888)2.37492099
44Cerebral edema (HP:0002181)2.36980415
45Septate vagina (HP:0001153)2.36605216
46Acute encephalopathy (HP:0006846)2.35678460
47Cerebral inclusion bodies (HP:0100314)2.33854313
48Neuroendocrine neoplasm (HP:0100634)2.30338598
49Abnormality of the preputium (HP:0100587)2.30193491
50Hypophosphatemic rickets (HP:0004912)2.30102641
51Increased CSF lactate (HP:0002490)2.29866758
52Congenital ichthyosiform erythroderma (HP:0007431)2.26627196
53Abnormality of methionine metabolism (HP:0010901)2.25741255
54Hypolipoproteinemia (HP:0010981)2.23848467
55Hyperammonemia (HP:0001987)2.22701531
56Abnormality of placental membranes (HP:0011409)2.21097864
57Amniotic constriction ring (HP:0009775)2.21097864
58Nephroblastoma (Wilms tumor) (HP:0002667)2.20459409
59Prolonged partial thromboplastin time (HP:0003645)2.20290914
60Supernumerary spleens (HP:0009799)2.19342119
61Abnormality of aspartate family amino acid metabolism (HP:0010899)2.18704193
62Limb dystonia (HP:0002451)2.17624879
63Hyperglycinuria (HP:0003108)2.17029418
64Acute necrotizing encephalopathy (HP:0006965)2.16791826
65Duodenal stenosis (HP:0100867)2.15880765
66Small intestinal stenosis (HP:0012848)2.15880765
67Horseshoe kidney (HP:0000085)2.15523007
68Increased hepatocellular lipid droplets (HP:0006565)2.14584490
69Embryonal renal neoplasm (HP:0011794)2.13224691
70Medulloblastoma (HP:0002885)2.11433674
71Delayed CNS myelination (HP:0002188)2.10295774
72Abnormality of the metopic suture (HP:0005556)2.09918240
73Spastic gait (HP:0002064)2.08756911
74Abnormality of the duodenum (HP:0002246)2.08656078
75Abnormality of serum amino acid levels (HP:0003112)2.08633524
76Neoplasm of the adrenal gland (HP:0100631)2.07245714
77Abnormality of the labia minora (HP:0012880)2.07199130
78Delayed myelination (HP:0012448)2.04311697
79Prominent metopic ridge (HP:0005487)2.02063329
80Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.00744294
81Methylmalonic aciduria (HP:0012120)2.00729015
82Sloping forehead (HP:0000340)2.00084434
83Hypoplastic female external genitalia (HP:0012815)2.00081922
84Postnatal microcephaly (HP:0005484)1.99545855
85Hepatocellular necrosis (HP:0001404)1.97731442
86Pancreatic islet-cell hyperplasia (HP:0004510)1.97038408
87Increased nuchal translucency (HP:0010880)1.95178447
88Pseudobulbar signs (HP:0002200)1.93289140
89Abnormality of sulfur amino acid metabolism (HP:0004339)1.92650265
90Abnormal mitochondria in muscle tissue (HP:0008316)1.91980464
91Lipid accumulation in hepatocytes (HP:0006561)1.91899410
92Generalized hypotonia (HP:0001290)1.91804414
93Adrenal hypoplasia (HP:0000835)1.91565152
94Epiphyseal stippling (HP:0010655)1.91462179
95Lethargy (HP:0001254)1.90529038
96Rhabdomyosarcoma (HP:0002859)1.90491766
97Abnormal gallbladder physiology (HP:0012438)1.90474905
98Cholecystitis (HP:0001082)1.90474905
99Aplasia/Hypoplasia involving the musculature (HP:0001460)1.90370532
100Absent septum pellucidum (HP:0001331)1.89218910
101Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.88618919
102Ketosis (HP:0001946)1.87455103
103Intestinal atresia (HP:0011100)1.87201789
104Cortical dysplasia (HP:0002539)1.86739547
105Hepatic necrosis (HP:0002605)1.86301465
106Glioma (HP:0009733)1.86028034
107True hermaphroditism (HP:0010459)1.84905289
108Dandy-Walker malformation (HP:0001305)1.84706064
109Pachygyria (HP:0001302)1.83817088
110Anomalous pulmonary venous return (HP:0010772)1.82153533
111Pancreatic fibrosis (HP:0100732)1.81555174
112Large earlobe (HP:0009748)1.80775030
113Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.79802147
114Abnormality of alanine metabolism (HP:0010916)1.79802147
115Hyperalaninemia (HP:0003348)1.79802147
116Sclerocornea (HP:0000647)1.79292667
117Brushfield spots (HP:0001088)1.78343284
118Absent radius (HP:0003974)1.77917623
119Broad alveolar ridges (HP:0000187)1.77827516
120Akinesia (HP:0002304)1.77657661
121Spastic paraparesis (HP:0002313)1.76676669
122Abnormality of pyrimidine metabolism (HP:0004353)1.76537672
123Volvulus (HP:0002580)1.76476948
124Abnormal hair whorl (HP:0010721)1.75883004
125Scrotal hypoplasia (HP:0000046)1.74262186
126Myokymia (HP:0002411)1.73906766
127Hemivertebrae (HP:0002937)1.73756115
128Triphalangeal thumb (HP:0001199)1.73355261
129Anophthalmia (HP:0000528)1.72485785
130* Increased serum lactate (HP:0002151)1.71872044
131Aplasia/Hypoplasia of the sternum (HP:0006714)1.71703238
132Aplasia involving forearm bones (HP:0009822)1.71272248
133Absent forearm bone (HP:0003953)1.71272248
134Preaxial hand polydactyly (HP:0001177)1.70832246
135Mitochondrial inheritance (HP:0001427)1.70507003
136Ankle clonus (HP:0011448)1.70463858
137Progressive macrocephaly (HP:0004481)1.69560796
138Abnormality of the astrocytes (HP:0100707)1.69530201
139Astrocytoma (HP:0009592)1.69530201
140Renal hypoplasia (HP:0000089)1.69153743
141Lactic acidosis (HP:0003128)1.68969698
142Ectopic kidney (HP:0000086)1.68791576
143Bilateral microphthalmos (HP:0007633)1.67009509
144Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.67004917
145Abnormality of the alveolar ridges (HP:0006477)1.66852996
146Abnormality of fatty-acid metabolism (HP:0004359)1.66666847
147Abnormality of the septum pellucidum (HP:0007375)1.66591251
148Labial hypoplasia (HP:0000066)1.66556251
149Abnormality of the carotid arteries (HP:0005344)1.65812371
150Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.65753752
151Hepatoblastoma (HP:0002884)1.65236693
152Methylmalonic acidemia (HP:0002912)1.64961755
153Microglossia (HP:0000171)1.64845203
154Irritability (HP:0000737)1.64466561
155Abnormality of the parathyroid morphology (HP:0011766)1.64215329
156Abnormality of midbrain morphology (HP:0002418)1.63842791
157Molar tooth sign on MRI (HP:0002419)1.63842791
158Turricephaly (HP:0000262)1.63584081
159Delusions (HP:0000746)1.63437728
160Opisthotonus (HP:0002179)1.63022063
161Spastic paraplegia (HP:0001258)1.62849734
162Lissencephaly (HP:0001339)1.62732487
163Hammertoe (HP:0001765)1.62658617
164Abnormality of the gallbladder (HP:0005264)1.62168191
165Bifid scrotum (HP:0000048)1.61794413
166Megalencephaly (HP:0001355)1.61548440
167Stridor (HP:0010307)1.60864683
168CNS demyelination (HP:0007305)1.60370085
169Abnormal epiphyseal ossification (HP:0010656)1.59422206

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.01880927
2STK393.25628330
3LIMK13.22500397
4DYRK23.21041731
5BCR3.06641318
6TRIM282.97452005
7TESK22.91142735
8CASK2.77065654
9PLK42.66922918
10ZAK2.45091365
11VRK22.39334571
12BUB12.37386302
13OXSR12.25981575
14UHMK12.13026007
15EIF2AK31.99385375
16CSNK1G31.90615078
17MKNK11.88736381
18TLK11.88511806
19FGFR21.86985447
20MST41.84928842
21EPHB21.81820037
22PBK1.73981034
23MAPK131.72611227
24NUAK11.72281991
25BRSK21.63898692
26LATS21.50111697
27WNK41.49497210
28BCKDK1.46544640
29MET1.43534318
30MINK11.42492877
31PKN11.40275265
32CSNK1G21.37952229
33EIF2AK11.37769768
34MAP4K21.37300235
35NTRK11.35848393
36CSNK1G11.33511341
37CSNK1A1L1.32883382
38CDK141.30677902
39STK161.30271450
40EPHB11.29982596
41SRPK11.29821078
42NME11.24114933
43TAF11.22863225
44KSR11.21324096
45PLK21.19730166
46ERBB41.18294926
47TESK11.15414133
48ATR1.15188761
49CDK181.14134059
50AURKA1.13233520
51CDK191.08880104
52CDK151.08161624
53NTRK21.04892094
54CHEK21.03737467
55PLK30.99992139
56CDK11A0.95614774
57PAK30.94543804
58AURKB0.93534477
59TYRO30.90811176
60BMPR1B0.90174989
61ICK0.89843088
62SGK4940.88262979
63SGK2230.88262979
64ERBB30.87041978
65ROCK20.84490212
66NEK10.83915577
67MAP3K40.82550406
68PDK20.82313880
69ACVR1B0.80719182
70DYRK30.80674660
71CDC70.78777415
72NEK20.78225828
73TSSK60.76671501
74ATM0.76469516
75PHKG20.73174231
76PHKG10.73174231
77PRPF4B0.70967882
78PAK60.70571059
79WNK30.70151613
80FGFR10.69694292
81CHEK10.69071982
82WEE10.68662896
83ABL20.67989689
84ALK0.65523552
85BRSK10.63563439
86CAMK2B0.63147770
87RPS6KA40.61600835
88TNIK0.60821859
89IRAK20.59688689
90ERBB20.59655229
91SIK10.59183834
92CSNK1E0.58160541
93PNCK0.57228313
94PRKCG0.56403983
95PAK40.55450727
96ADRBK10.55087524
97CSNK2A10.53030246
98PRKCZ0.51546135
99ILK0.50215999
100PAK10.50191823
101EPHA40.49662471
102MAP3K90.49287903
103STK40.49241626
104CDK70.49053455
105CDK50.47513385
106PLK10.47451010
107FER0.47428628
108VRK10.47300896
109TGFBR10.46177460
110MAP2K10.46177324
111FGR0.45298421
112BRAF0.43388715
113GSK3A0.43237037
114EPHA30.42605352
115MAP2K40.42027919
116YES10.41890668
117PRKDC0.41017912
118ROCK10.40848870
119MAPKAPK50.40386628
120CDK30.40007343
121CDK20.38732186
122CDK10.38056129
123TTK0.37133573
124EIF2AK20.36431863
125INSRR0.35652018
126MKNK20.35442870
127DDR20.35383954
128PRKCI0.35318813
129CSNK2A20.35028050
130TIE10.34778009
131CCNB10.34346392
132MAP2K70.34076739
133PASK0.33361237
134MAP3K80.33216360
135GRK10.32772291
136DAPK10.32374168
137CSNK1A10.31814497
138STK38L0.30579158
139STK100.29751841
140STK30.27343289
141MAP3K120.24814761

Predicted pathways (KEGG)

RankGene SetZ-score
1Steroid biosynthesis_Homo sapiens_hsa001005.48372484
2* Terpenoid backbone biosynthesis_Homo sapiens_hsa009004.92882079
3Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.91987412
4* Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.75579738
5Fatty acid elongation_Homo sapiens_hsa000623.20057240
6* Butanoate metabolism_Homo sapiens_hsa006502.51520210
7Primary bile acid biosynthesis_Homo sapiens_hsa001202.48324896
8Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.40231889
9Non-homologous end-joining_Homo sapiens_hsa034502.37674827
10* Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.19920929
11Homologous recombination_Homo sapiens_hsa034402.16357852
12* Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.12168457
13Base excision repair_Homo sapiens_hsa034102.03479423
14* Fatty acid metabolism_Homo sapiens_hsa012121.98070478
15Proteasome_Homo sapiens_hsa030501.87919255
16Fanconi anemia pathway_Homo sapiens_hsa034601.84750220
17* Propanoate metabolism_Homo sapiens_hsa006401.78378194
182-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.76230097
19Peroxisome_Homo sapiens_hsa041461.74856119
20Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.70101079
21* Pyruvate metabolism_Homo sapiens_hsa006201.54320161
22* Fatty acid degradation_Homo sapiens_hsa000711.52384618
23Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.42446149
24Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.42341550
25* Tryptophan metabolism_Homo sapiens_hsa003801.40672884
26RNA degradation_Homo sapiens_hsa030181.38288375
27Arginine biosynthesis_Homo sapiens_hsa002201.37222518
28Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.36550824
29Nitrogen metabolism_Homo sapiens_hsa009101.34699020
30Cyanoamino acid metabolism_Homo sapiens_hsa004601.32989388
31Steroid hormone biosynthesis_Homo sapiens_hsa001401.32407018
32Tyrosine metabolism_Homo sapiens_hsa003501.32342430
33Vitamin B6 metabolism_Homo sapiens_hsa007501.29476801
34Sulfur metabolism_Homo sapiens_hsa009201.28448414
35Biosynthesis of amino acids_Homo sapiens_hsa012301.26971108
36Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.25709295
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.25120871
38Histidine metabolism_Homo sapiens_hsa003401.23559683
39PPAR signaling pathway_Homo sapiens_hsa033201.22846146
40* Carbon metabolism_Homo sapiens_hsa012001.18842899
41Retinol metabolism_Homo sapiens_hsa008301.18540544
42Chemical carcinogenesis_Homo sapiens_hsa052041.17689109
43Oxidative phosphorylation_Homo sapiens_hsa001901.17041713
44Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.15692986
45Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.14708636
46Phenylalanine metabolism_Homo sapiens_hsa003601.13501511
47Glutathione metabolism_Homo sapiens_hsa004801.10701174
48beta-Alanine metabolism_Homo sapiens_hsa004101.10074484
49Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.08462897
50Fatty acid biosynthesis_Homo sapiens_hsa000611.07351559
51Cysteine and methionine metabolism_Homo sapiens_hsa002701.04328819
52Parkinsons disease_Homo sapiens_hsa050121.02900499
53One carbon pool by folate_Homo sapiens_hsa006701.02068092
54Arginine and proline metabolism_Homo sapiens_hsa003301.00095697
55Drug metabolism - other enzymes_Homo sapiens_hsa009830.99375173
56Axon guidance_Homo sapiens_hsa043600.95172535
57Complement and coagulation cascades_Homo sapiens_hsa046100.93989006
58Purine metabolism_Homo sapiens_hsa002300.91022102
59Selenocompound metabolism_Homo sapiens_hsa004500.84540915
60Pentose and glucuronate interconversions_Homo sapiens_hsa000400.78843678
61Ether lipid metabolism_Homo sapiens_hsa005650.75178008
62Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.69643920
63RNA polymerase_Homo sapiens_hsa030200.67598181
64* Metabolic pathways_Homo sapiens_hsa011000.65653119
65Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.63479003
66Folate biosynthesis_Homo sapiens_hsa007900.62404675
67Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.61250064
68Alzheimers disease_Homo sapiens_hsa050100.57583559
69Huntingtons disease_Homo sapiens_hsa050160.57133459
70Spliceosome_Homo sapiens_hsa030400.56772054
71Bile secretion_Homo sapiens_hsa049760.56237255
72Sulfur relay system_Homo sapiens_hsa041220.54557522
73p53 signaling pathway_Homo sapiens_hsa041150.50365247
74Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.50296744
75Pentose phosphate pathway_Homo sapiens_hsa000300.48728509
76Basal cell carcinoma_Homo sapiens_hsa052170.47575105
77Cardiac muscle contraction_Homo sapiens_hsa042600.47107426
78Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.46659669
79Ribosome_Homo sapiens_hsa030100.43345646
80alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.43160154
81Hedgehog signaling pathway_Homo sapiens_hsa043400.42175792
82Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.41497750
83Phototransduction_Homo sapiens_hsa047440.41327826
84Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.39729821
85Pyrimidine metabolism_Homo sapiens_hsa002400.37271357
86* Fat digestion and absorption_Homo sapiens_hsa049750.35808504
87Linoleic acid metabolism_Homo sapiens_hsa005910.34669425
88N-Glycan biosynthesis_Homo sapiens_hsa005100.34390409
89Hippo signaling pathway_Homo sapiens_hsa043900.33877796
90DNA replication_Homo sapiens_hsa030300.33377640
91RNA transport_Homo sapiens_hsa030130.32974950
92Mismatch repair_Homo sapiens_hsa034300.32100123
93Nicotine addiction_Homo sapiens_hsa050330.31529438
94Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.31338917
95Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.30575587
96Glycerolipid metabolism_Homo sapiens_hsa005610.30525148
97Prion diseases_Homo sapiens_hsa050200.28811015
98Wnt signaling pathway_Homo sapiens_hsa043100.27556657
99Vitamin digestion and absorption_Homo sapiens_hsa049770.26262889
100Nucleotide excision repair_Homo sapiens_hsa034200.25131038
101Tight junction_Homo sapiens_hsa045300.23947610
102TGF-beta signaling pathway_Homo sapiens_hsa043500.23445844
103Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.19696975
104Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.19680731
105Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.19667805
106Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.19225278
107Cell cycle_Homo sapiens_hsa041100.17826932
108Protein export_Homo sapiens_hsa030600.17622473
109mRNA surveillance pathway_Homo sapiens_hsa030150.16658278
110Caffeine metabolism_Homo sapiens_hsa002320.15743377
111AMPK signaling pathway_Homo sapiens_hsa041520.14297779
112Oocyte meiosis_Homo sapiens_hsa041140.12069101
113Starch and sucrose metabolism_Homo sapiens_hsa005000.10683702
114Systemic lupus erythematosus_Homo sapiens_hsa053220.09779759
115Renal cell carcinoma_Homo sapiens_hsa052110.09456159
116Alcoholism_Homo sapiens_hsa050340.08716540
117Vibrio cholerae infection_Homo sapiens_hsa051100.08682610
118Basal transcription factors_Homo sapiens_hsa030220.08409082

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