ACBD3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. The protein encoded by this gene is involved in the maintenance of Golgi structure and function through its interaction with the integral membrane protein giantin. It may also be involved in the hormonal regulation of steroid formation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.12789274
2desmosome organization (GO:0002934)4.63074586
3nuclear pore organization (GO:0006999)4.48529348
4cellular protein complex localization (GO:0034629)3.80528916
5vesicle coating (GO:0006901)3.67723823
6pore complex assembly (GO:0046931)3.52436291
7maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.51663690
8UDP-N-acetylglucosamine metabolic process (GO:0006047)3.50578370
9cytoplasmic mRNA processing body assembly (GO:0033962)3.47493310
10ER overload response (GO:0006983)3.46068131
11regulation of transforming growth factor beta1 production (GO:0032908)3.38676686
12bundle of His cell to Purkinje myocyte communication (GO:0086069)3.34146166
13hemidesmosome assembly (GO:0031581)3.22716799
14protein retention in ER lumen (GO:0006621)3.18387215
15protein localization to endosome (GO:0036010)3.16339680
16regulation of RNA export from nucleus (GO:0046831)3.08202528
17regulation of nucleobase-containing compound transport (GO:0032239)3.05119470
18iron ion import (GO:0097286)3.05067406
19protein complex localization (GO:0031503)3.00845393
20chondrocyte development (GO:0002063)2.96425482
21cell adhesion mediated by integrin (GO:0033627)2.95713390
22epithelial cell-cell adhesion (GO:0090136)2.95141310
23negative regulation of protein localization to plasma membrane (GO:1903077)2.89966048
24wound healing, spreading of epidermal cells (GO:0035313)2.86779897
25nucleotide-sugar biosynthetic process (GO:0009226)2.86320655
26hippo signaling (GO:0035329)2.83762464
27hypotonic response (GO:0006971)2.83194187
28collagen fibril organization (GO:0030199)2.80988414
29retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.78364061
30activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.76944758
31surfactant homeostasis (GO:0043129)2.76286974
32anterior/posterior axis specification, embryo (GO:0008595)2.73861801
33chemical homeostasis within a tissue (GO:0048875)2.70974760
34endoplasmic reticulum unfolded protein response (GO:0030968)2.70253037
35regulation of glucocorticoid metabolic process (GO:0031943)2.70149892
36sequestering of extracellular ligand from receptor (GO:0035581)2.69527277
37positive regulation of nuclease activity (GO:0032075)2.69073559
38modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.65907002
39positive regulation by organism of defense response of other organism involved in symbiotic interact2.65907002
40modulation by symbiont of host immune response (GO:0052553)2.65907002
41positive regulation by symbiont of host defense response (GO:0052509)2.65907002
42modulation by symbiont of host defense response (GO:0052031)2.65907002
43modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.65907002
44ER-nucleus signaling pathway (GO:0006984)2.62950933
45positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.60784140
46regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.60712513
47regulation of early endosome to late endosome transport (GO:2000641)2.60673015
48paraxial mesoderm development (GO:0048339)2.60378309
49positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.59939791
50ribosome assembly (GO:0042255)2.59626228
51mammary gland epithelial cell proliferation (GO:0033598)2.58908672
52positive regulation of mitotic sister chromatid separation (GO:1901970)2.58882299
53positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.58882299
54platelet-derived growth factor receptor signaling pathway (GO:0048008)2.58879931
55positive regulation of p38MAPK cascade (GO:1900745)2.58225388
56embryonic process involved in female pregnancy (GO:0060136)2.56813281
57regulation of establishment of cell polarity (GO:2000114)2.56749549
58regulation of cardioblast differentiation (GO:0051890)2.56504536
59regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.56286460
60diterpenoid biosynthetic process (GO:0016102)2.55972136
61protein hydroxylation (GO:0018126)2.55216009
62cell-substrate junction assembly (GO:0007044)2.54761635
63regulation of dendritic cell antigen processing and presentation (GO:0002604)2.54166204
64cellular response to unfolded protein (GO:0034620)2.53836965
65T-helper 1 type immune response (GO:0042088)2.51742990
66kidney mesenchyme development (GO:0072074)2.49998270
67regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.47631768
68regulation of nuclease activity (GO:0032069)2.47230395
69ganglion development (GO:0061548)2.46438543
70dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.46116696
71positive regulation of NIK/NF-kappaB signaling (GO:1901224)2.45056115
72Golgi organization (GO:0007030)2.42464273
73antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.41970693
74polarized epithelial cell differentiation (GO:0030859)2.41099065
75peptidyl-proline hydroxylation (GO:0019511)2.40803535
76regulation of mononuclear cell migration (GO:0071675)2.40373160
77regulation of transforming growth factor beta2 production (GO:0032909)2.39328409
78cellular response to vitamin D (GO:0071305)2.38996840
79growth hormone receptor signaling pathway (GO:0060396)2.38963096
80gap junction assembly (GO:0016264)2.37874805
81mitotic chromosome condensation (GO:0007076)2.37656086
82regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.37122116
83granulocyte activation (GO:0036230)2.35659258
84ER to Golgi vesicle-mediated transport (GO:0006888)2.35112358
85cytoskeleton-dependent cytokinesis (GO:0061640)2.34625318
86type B pancreatic cell development (GO:0003323)2.34466858
87neutrophil activation (GO:0042119)2.31427552
88protein N-linked glycosylation via asparagine (GO:0018279)2.30794586
89stress fiber assembly (GO:0043149)2.30651046
90cell migration involved in sprouting angiogenesis (GO:0002042)2.30573740
91regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.29803995
92regulation of integrin activation (GO:0033623)2.29278960
93negative regulation of fatty acid transport (GO:2000192)2.28791557
94peptidyl-asparagine modification (GO:0018196)2.28748591
95regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.28332597
96negative regulation of keratinocyte proliferation (GO:0010839)2.26997496
97positive regulation of macroautophagy (GO:0016239)2.25192707
98endodermal cell differentiation (GO:0035987)2.25053900
99basement membrane organization (GO:0071711)2.24710706
100adherens junction assembly (GO:0034333)2.24548562
101cellular response to topologically incorrect protein (GO:0035967)2.24375639
102mitotic sister chromatid cohesion (GO:0007064)2.23259778
103metanephric mesenchyme development (GO:0072075)2.22790676
104negative regulation of chondrocyte differentiation (GO:0032331)2.22341434
105fibroblast migration (GO:0010761)2.22327327
106Rap protein signal transduction (GO:0032486)2.21533156
107regulation of interleukin-8 secretion (GO:2000482)2.20279393
108wound healing, spreading of cells (GO:0044319)2.20126731
109neutrophil activation involved in immune response (GO:0002283)2.19658727
110regulation of sister chromatid cohesion (GO:0007063)2.19364837
111histone H3-K36 demethylation (GO:0070544)2.19265577
112regulation of translational fidelity (GO:0006450)2.18962868
113mitotic cytokinesis (GO:0000281)2.18764019
114response to endoplasmic reticulum stress (GO:0034976)2.18724834
115ovulation from ovarian follicle (GO:0001542)2.18679762
116regulation of transforming growth factor beta production (GO:0071634)2.18321463
117positive regulation of osteoblast proliferation (GO:0033690)2.18285284
118chondrocyte proliferation (GO:0035988)2.18196126
119cellular response to interferon-alpha (GO:0035457)2.17458622
120regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.17417272
121regulation of establishment or maintenance of cell polarity (GO:0032878)2.17290589
122face morphogenesis (GO:0060325)2.16233113
123response to unfolded protein (GO:0006986)2.15196425
124regulation of interferon-beta biosynthetic process (GO:0045357)2.14787175
125keratinocyte proliferation (GO:0043616)2.14077183
126protein N-linked glycosylation (GO:0006487)2.14036155
127regulation of interleukin-12 biosynthetic process (GO:0045075)2.12784386
128cellular response to ATP (GO:0071318)2.12385532
129production of molecular mediator involved in inflammatory response (GO:0002532)2.09754826
130keratan sulfate catabolic process (GO:0042340)2.09424044
131collagen catabolic process (GO:0030574)2.08564032
132COPII vesicle coating (GO:0048208)2.08298978
133heterotypic cell-cell adhesion (GO:0034113)2.08007698
134collagen metabolic process (GO:0032963)2.07883329
135regulation of protein polyubiquitination (GO:1902914)2.07521205
136retina vasculature morphogenesis in camera-type eye (GO:0061299)2.05453995
137positive regulation of hormone biosynthetic process (GO:0046886)2.04788996
138sequestering of metal ion (GO:0051238)2.04649467
139Golgi transport vesicle coating (GO:0048200)2.04515541
140COPI coating of Golgi vesicle (GO:0048205)2.04515541
141leukocyte tethering or rolling (GO:0050901)2.04161949
142replicative senescence (GO:0090399)2.03990371
143positive regulation of chemokine biosynthetic process (GO:0045080)2.03884287
144hepatocyte apoptotic process (GO:0097284)2.03356962
145telomere maintenance via telomerase (GO:0007004)2.02977178
146I-kappaB phosphorylation (GO:0007252)2.02825162
147establishment of endothelial barrier (GO:0061028)2.02247619
148positive regulation of interferon-alpha production (GO:0032727)2.01595343
149superoxide anion generation (GO:0042554)2.01579108
150intestinal epithelial cell development (GO:0060576)1.99624005
151cellular response to growth hormone stimulus (GO:0071378)1.99541815
152myoblast migration (GO:0051451)1.98974116
153T-helper cell differentiation (GO:0042093)1.96996851
154CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)1.96996851
155skin morphogenesis (GO:0043589)1.96536159
156positive regulation of chemokine production (GO:0032722)1.95895707
157regulation of NIK/NF-kappaB signaling (GO:1901222)1.95757720
158JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)1.95609389
159negative regulation of smooth muscle cell differentiation (GO:0051151)1.95375119
160vascular endothelial growth factor signaling pathway (GO:0038084)1.95370981
161histone H2A monoubiquitination (GO:0035518)1.95000095
162multicellular organismal macromolecule metabolic process (GO:0044259)1.94772065
163eosinophil chemotaxis (GO:0048245)1.94389258
164multicellular organismal catabolic process (GO:0044243)1.94365981
165natural killer cell mediated immunity (GO:0002228)1.93820558
166natural killer cell mediated cytotoxicity (GO:0042267)1.93820558
167activated T cell proliferation (GO:0050798)1.93386372
168negative regulation of establishment of protein localization to plasma membrane (GO:0090005)1.93234499
169cellular response to vitamin (GO:0071295)1.91903297
170positive regulation of protein autophosphorylation (GO:0031954)1.91192984
171positive regulation of Cdc42 GTPase activity (GO:0043089)1.91113618
172mesodermal cell differentiation (GO:0048333)1.91041925
173multicellular organismal metabolic process (GO:0044236)1.90913420
174detection of other organism (GO:0098543)1.90494060
175embryonic camera-type eye morphogenesis (GO:0048596)1.90273348
176regulation of interferon-alpha production (GO:0032647)1.89080211
177columnar/cuboidal epithelial cell development (GO:0002066)1.88128573
178regulation of chemokine-mediated signaling pathway (GO:0070099)1.88077611
179negative regulation of B cell proliferation (GO:0030889)1.87830653
180positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)1.87142661

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human3.46746103
2E2F7_22180533_ChIP-Seq_HELA_Human3.43723598
3AR_21909140_ChIP-Seq_LNCAP_Human3.29418735
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.18494517
5CLOCK_20551151_ChIP-Seq_293T_Human2.94881654
6TRIM28_21343339_ChIP-Seq_HEK293_Human2.70137890
7STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.55973308
8IRF8_22096565_ChIP-ChIP_GC-B_Human2.51302764
9TP63_17297297_ChIP-ChIP_HaCaT_Human2.44238388
10PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.42167722
11Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.38469594
12CDX2_19796622_ChIP-Seq_MESCs_Mouse2.36270398
13CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.33660948
14* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.32427511
15SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse2.29339418
16NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.29166691
17SMAD_19615063_ChIP-ChIP_OVARY_Human2.28994677
18KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human2.28316830
19SALL1_21062744_ChIP-ChIP_HESCs_Human2.27239663
20EGR1_19374776_ChIP-ChIP_THP-1_Human2.18335647
21STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.10362901
22IRF8_21731497_ChIP-ChIP_J774_Mouse2.10353350
23STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.02453779
24ZNF217_24962896_ChIP-Seq_MCF-7_Human1.96002460
25CJUN_26792858_Chip-Seq_BT549_Human1.94597555
26IRF8_27001747_Chip-Seq_BMDM_Mouse1.89145316
27CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.87245953
28SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.84474492
29FOXM1_23109430_ChIP-Seq_U2OS_Human1.82839024
30SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.79630849
31WT1_19549856_ChIP-ChIP_CCG9911_Human1.79306357
32* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.78281117
33IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.75757638
34* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.71120911
35KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.68518416
36TFEB_21752829_ChIP-Seq_HELA_Human1.68148768
37* CHD1_26751641_Chip-Seq_LNCaP_Human1.68119191
38PCGF2_27294783_Chip-Seq_ESCs_Mouse1.64764903
39VDR_24787735_ChIP-Seq_THP-1_Human1.64180011
40NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.59726005
41TP63_19390658_ChIP-ChIP_HaCaT_Human1.59382750
42RARG_19884340_ChIP-ChIP_MEFs_Mouse1.58636966
43* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.58504800
44ESR2_21235772_ChIP-Seq_MCF-7_Human1.57955057
45TP53_16413492_ChIP-PET_HCT116_Human1.52829713
46BRD4_25478319_ChIP-Seq_HGPS_Human1.51910749
47EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.51535565
48FLI1_27457419_Chip-Seq_LIVER_Mouse1.51266242
49PCGF2_27294783_Chip-Seq_NPCs_Mouse1.48502097
50BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.48323736
51SOX2_27498859_Chip-Seq_STOMACH_Mouse1.47911388
52P300_27058665_Chip-Seq_ZR-75-30cells_Human1.44718315
53RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.44368097
54ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.43013823
55ESR1_21235772_ChIP-Seq_MCF-7_Human1.42738517
56AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.42595074
57RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.42114580
58TP53_18474530_ChIP-ChIP_U2OS_Human1.40265190
59SUZ12_27294783_Chip-Seq_NPCs_Mouse1.39876591
60PPAR_26484153_Chip-Seq_NCI-H1993_Human1.39314750
61TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.38831947
62GATA2_21666600_ChIP-Seq_HMVEC_Human1.38397383
63ATF3_27146783_Chip-Seq_COLON_Human1.37970779
64GATA3_24758297_ChIP-Seq_MCF-7_Human1.37754805
65HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.37217737
66ZNF263_19887448_ChIP-Seq_K562_Human1.36231803
67SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.36214745
68SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.36214745
69RBPJ_22232070_ChIP-Seq_NCS_Mouse1.36122409
70NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.35901363
71NRF2_20460467_ChIP-Seq_MEFs_Mouse1.35901363
72* EZH2_27294783_Chip-Seq_NPCs_Mouse1.35291141
73POU3F2_20337985_ChIP-ChIP_501MEL_Human1.34955814
74FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.34571781
75FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.33505010
76FOXO3_23340844_ChIP-Seq_DLD1_Human1.32828009
77* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.32477476
78NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.32307608
79ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.29426473
80STAT6_21828071_ChIP-Seq_BEAS2B_Human1.28865474
81* GATA6_25053715_ChIP-Seq_YYC3_Human1.27122989
82* NFE2_27457419_Chip-Seq_LIVER_Mouse1.26025804
83PIAS1_25552417_ChIP-Seq_VCAP_Human1.25933907
84SALL4_18804426_ChIP-ChIP_XEN_Mouse1.24967382
85IGF1R_20145208_ChIP-Seq_DFB_Human1.24573978
86NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.24009283
87MYB_21317192_ChIP-Seq_ERMYB_Mouse1.23502806
88* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.23381327
89CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.22679920
90FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.22595835
91PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.22360971
92* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.21685612
93MYCN_18555785_ChIP-Seq_MESCs_Mouse1.21108242
94* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.20397196
95* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.20160409
96ESR1_20079471_ChIP-ChIP_T-47D_Human1.18234407
97* NANOG_18555785_Chip-Seq_ESCs_Mouse1.18101436
98TP63_23658742_ChIP-Seq_EP156T_Human1.17465108
99ELF5_23300383_ChIP-Seq_T47D_Human1.17243575
100SOX2_20726797_ChIP-Seq_SW620_Human1.15979888
101* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.15758894
102WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.15484746
103GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14959753
104JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.14733068
105FOXM1_26456572_ChIP-Seq_MCF-7_Human1.14266362
106SOX9_24532713_ChIP-Seq_HFSC_Mouse1.13900782
107TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.13755158
108* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.13175773
109RUNX_20019798_ChIP-Seq_JUKART_Human1.13132105
110RXR_22108803_ChIP-Seq_LS180_Human1.10623452
111VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.10070065
112* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.10015330
113PADI4_21655091_ChIP-ChIP_MCF-7_Human1.09715440
114FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.09400874
115DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.09209669
116TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.09036551
117PU_27001747_Chip-Seq_BMDM_Mouse1.08330255
118JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.07070328
119TCF4_18268006_ChIP-ChIP_LS174T_Human1.06957192
120FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.06738476
121PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05308816
122ELK1_19687146_ChIP-ChIP_HELA_Human1.05204365
123CDX2_22108803_ChIP-Seq_LS180_Human1.04332920
124* E2F1_18555785_Chip-Seq_ESCs_Mouse1.04202100
125AHR_22903824_ChIP-Seq_MCF-7_Human1.03690298
126FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.03091330
127PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02965174
128MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.02376141
129CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.01939731
130GATA4_21415370_ChIP-Seq_HL-1_Mouse0.99667879
131EP300_21415370_ChIP-Seq_HL-1_Mouse0.98770121
132* P53_22387025_ChIP-Seq_ESCs_Mouse0.98504117
133* CMYC_18555785_Chip-Seq_ESCs_Mouse0.97616519
134MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.97377317
135* NMYC_18555785_Chip-Seq_ESCs_Mouse0.96831645
136STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.96364551
137* OCT4_21477851_ChIP-Seq_ESCs_Mouse0.96153931
138FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.96092673
139STAT3_23295773_ChIP-Seq_U87_Human0.95807024
140* STAT3_18555785_Chip-Seq_ESCs_Mouse0.95373125
141PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.94996840
142* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.94941219
143UBF1/2_26484160_Chip-Seq_HMECs_Human0.94249007
144HIF1A_21447827_ChIP-Seq_MCF-7_Human0.94150492
145* CRX_20693478_ChIP-Seq_RETINA_Mouse0.94006234
146* SUZ12_18555785_Chip-Seq_ESCs_Mouse0.93880399
147* E2F1_21310950_ChIP-Seq_MCF-7_Human0.93232847
148PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.93024902
149SOX17_20123909_ChIP-Seq_XEN_Mouse0.92944001
150CTNNB1_20460455_ChIP-Seq_HCT116_Human0.92848210
151ARNT_22903824_ChIP-Seq_MCF-7_Human0.92642101
152* OCT4_18555785_Chip-Seq_ESCs_Mouse0.90572669
153* PU1_27457419_Chip-Seq_LIVER_Mouse0.86411407

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002877_abnormal_melanocyte_morpholog3.46827893
2MP0008438_abnormal_cutaneous_collagen3.33010863
3MP0000569_abnormal_digit_pigmentation2.80633238
4MP0008057_abnormal_DNA_replication2.62534237
5MP0003950_abnormal_plasma_membrane2.46877559
6MP0005275_abnormal_skin_tensile2.40421370
7MP0005257_abnormal_intraocular_pressure2.34477602
8MP0005076_abnormal_cell_differentiation2.31144097
9MP0009780_abnormal_chondrocyte_physiolo2.27539425
10MP0003566_abnormal_cell_adhesion2.16541373
11MP0003303_peritoneal_inflammation2.12200179
12MP0003300_gastrointestinal_ulcer2.11395527
13MP0010352_gastrointestinal_tract_polyps2.10819496
14MP0005503_abnormal_tendon_morphology2.07337031
15MP0003705_abnormal_hypodermis_morpholog1.96501827
16MP0003091_abnormal_cell_migration1.83983610
17MP0003941_abnormal_skin_development1.72587282
18MP0002796_impaired_skin_barrier1.69225367
19MP0002933_joint_inflammation1.56149381
20MP0004272_abnormal_basement_membrane1.52492592
21MP0002060_abnormal_skin_morphology1.51031627
22MP0003045_fibrosis1.49266241
23MP0003436_decreased_susceptibility_to1.47111117
24MP0003448_altered_tumor_morphology1.46055430
25MP0005508_abnormal_skeleton_morphology1.44348123
26MP0002998_abnormal_bone_remodeling1.42891870
27MP0006082_CNS_inflammation1.41010335
28MP0002896_abnormal_bone_mineralization1.38370853
29MP0006054_spinal_hemorrhage1.36444624
30MP0005248_abnormal_Harderian_gland1.35905293
31MP0005390_skeleton_phenotype1.35224562
32MP0001533_abnormal_skeleton_physiology1.34714092
33MP0004957_abnormal_blastocyst_morpholog1.34440142
34MP0002009_preneoplasia1.34369496
35MP0003724_increased_susceptibility_to1.33867085
36MP0004233_abnormal_muscle_weight1.33684206
37MP0005623_abnormal_meninges_morphology1.31181830
38MP0003453_abnormal_keratinocyte_physiol1.30691694
39MP0003191_abnormal_cellular_cholesterol1.28811153
40MP0002254_reproductive_system_inflammat1.28684176
41MP0005171_absent_coat_pigmentation1.27740485
42MP0010678_abnormal_skin_adnexa1.27669471
43MP0003279_aneurysm1.27240704
44MP0000767_abnormal_smooth_muscle1.24852304
45MP0000013_abnormal_adipose_tissue1.24685025
46MP0001915_intracranial_hemorrhage1.24268195
47MP0001958_emphysema1.23045038
48MP0000762_abnormal_tongue_morphology1.22141016
49MP0009250_abnormal_appendicular_skeleto1.20287073
50MP0005000_abnormal_immune_tolerance1.18292311
51MP0000733_abnormal_muscle_development1.17978892
52MP0002419_abnormal_innate_immunity1.17593898
53MP0005023_abnormal_wound_healing1.17580694
54MP0005310_abnormal_salivary_gland1.16500959
55MP0004510_myositis1.16454399
56MP0000516_abnormal_urinary_system1.14401592
57MP0005367_renal/urinary_system_phenotyp1.14401592
58MP0000537_abnormal_urethra_morphology1.14174995
59MP0002115_abnormal_skeleton_extremities1.13592484
60MP0001790_abnormal_immune_system1.13070717
61MP0005387_immune_system_phenotype1.13070717
62MP0002086_abnormal_extraembryonic_tissu1.12931113
63MP0010307_abnormal_tumor_latency1.11413591
64MP0001346_abnormal_lacrimal_gland1.10335505
65MP0002148_abnormal_hypersensitivity_rea1.10334359
66MP0003385_abnormal_body_wall1.10169457
67MP0004185_abnormal_adipocyte_glucose1.09569190
68MP0002405_respiratory_system_inflammati1.08685126
69MP0003787_abnormal_imprinting1.08330525
70MP0003795_abnormal_bone_structure1.08106184
71MP0005409_darkened_coat_color1.07852212
72MP0001730_embryonic_growth_arrest1.07596511
73MP0009840_abnormal_foam_cell1.07386756
74MP0003937_abnormal_limbs/digits/tail_de1.07044774
75MP0003984_embryonic_growth_retardation1.06841767
76MP0001672_abnormal_embryogenesis/_devel1.06558894
77MP0005380_embryogenesis_phenotype1.06558894
78MP0001835_abnormal_antigen_presentation1.05703944
79MP0002113_abnormal_skeleton_development1.05086146
80MP0002006_tumorigenesis1.04773385
81MP0002277_abnormal_respiratory_mucosa1.04490445
82MP0004947_skin_inflammation1.04335743
83MP0002088_abnormal_embryonic_growth/wei1.04333618
84MP0002452_abnormal_antigen_presenting1.03615152
85MP0005501_abnormal_skin_physiology1.03305910
86MP0001661_extended_life_span1.02573606
87MP0004782_abnormal_surfactant_physiolog1.02031804
88MP0000627_abnormal_mammary_gland1.01883575
89MP0002138_abnormal_hepatobiliary_system1.01517437
90MP0000858_altered_metastatic_potential1.01309142
91MP0000163_abnormal_cartilage_morphology1.00509410
92MP0001851_eye_inflammation0.99961321
93MP0000465_gastrointestinal_hemorrhage0.99750118
94MP0000432_abnormal_head_morphology0.99443823
95MP0001879_abnormal_lymphatic_vessel0.99392978
96MP0003890_abnormal_embryonic-extraembry0.99317661
97MP0002084_abnormal_developmental_patter0.98871778
98MP0002295_abnormal_pulmonary_circulatio0.98190570
99MP0003755_abnormal_palate_morphology0.97896959
100MP0005408_hypopigmentation0.96607195
101MP0002168_other_aberrant_phenotype0.96412973
102MP0004134_abnormal_chest_morphology0.96137860
103MP0000377_abnormal_hair_follicle0.95760332
104MP0003828_pulmonary_edema0.95571879
105MP0003868_abnormal_feces_composition0.95252535
106MP0005451_abnormal_body_composition0.94959660
107MP0001243_abnormal_dermal_layer0.93825574
108MP0002108_abnormal_muscle_morphology0.93620236
109MP0002098_abnormal_vibrissa_morphology0.91973805
110MP0001299_abnormal_eye_distance/0.91925548
111MP0000350_abnormal_cell_proliferation0.91746717
112MP0002109_abnormal_limb_morphology0.91501429
113MP0010234_abnormal_vibrissa_follicle0.91437824
114MP0005621_abnormal_cell_physiology0.91277606
115MP0005197_abnormal_uvea_morphology0.90698479
116MP0009384_cardiac_valve_regurgitation0.89059762
117MP0003935_abnormal_craniofacial_develop0.88646851
118MP0002693_abnormal_pancreas_physiology0.88572554
119MP0004264_abnormal_extraembryonic_tissu0.86412003
120MP0004808_abnormal_hematopoietic_stem0.85838976
121MP0010386_abnormal_urinary_bladder0.84781710
122MP0008007_abnormal_cellular_replicative0.84611333
123MP0001697_abnormal_embryo_size0.84337132
124MP0009278_abnormal_bone_marrow0.83581484
125MP0000613_abnormal_salivary_gland0.83576546
126MP0002166_altered_tumor_susceptibility0.83231748
127MP0001216_abnormal_epidermal_layer0.81960351
128MP0002723_abnormal_immune_serum0.81266602
129MP0001881_abnormal_mammary_gland0.80066121
130MP0001800_abnormal_humoral_immune0.79782013
131MP0001542_abnormal_bone_strength0.79346173
132MP0002163_abnormal_gland_morphology0.78705971
133MP0000003_abnormal_adipose_tissue0.78521107
134MP0002085_abnormal_embryonic_tissue0.77359870
135MP0001819_abnormal_immune_cell0.77009909
136MP0000428_abnormal_craniofacial_morphol0.76666093
137MP0010155_abnormal_intestine_physiology0.76349569
138MP0002420_abnormal_adaptive_immunity0.76218648
139MP0003077_abnormal_cell_cycle0.76090050
140MP0003693_abnormal_embryo_hatching0.75539129
141MP0002269_muscular_atrophy0.74654115
142MP0010030_abnormal_orbit_morphology0.73955636
143MP0008004_abnormal_stomach_pH0.73926353
144MP0005058_abnormal_lysosome_morphology0.73885235
145MP0000371_diluted_coat_color0.73245932
146MP0002925_abnormal_cardiovascular_devel0.72497521
147MP0002080_prenatal_lethality0.72497206
148MP0010368_abnormal_lymphatic_system0.72432284
149MP0003111_abnormal_nucleus_morphology0.72419219
150MP0008932_abnormal_embryonic_tissue0.72292311
151MP0000467_abnormal_esophagus_morphology0.72247340
152MP0004084_abnormal_cardiac_muscle0.71397477

Predicted human phenotypes

RankGene SetZ-score
1Hypoplastic ischia (HP:0003175)3.52231329
2Right ventricular cardiomyopathy (HP:0011663)3.34741349
3Epiphyseal dysplasia (HP:0002656)3.34474104
4Premature rupture of membranes (HP:0001788)3.32623117
5Ankyloglossia (HP:0010296)3.21518994
6Eczematoid dermatitis (HP:0000976)3.08464438
7Abnormality of the ischium (HP:0003174)3.02096628
8Small epiphyses (HP:0010585)2.86842208
9Fragile skin (HP:0001030)2.67246375
10Abnormality of the fingertips (HP:0001211)2.65870731
11Lip pit (HP:0100267)2.58401292
12Cupped ribs (HP:0000887)2.57610309
13Aortic dissection (HP:0002647)2.57494196
14Abnormality of oral frenula (HP:0000190)2.54088376
15Bladder diverticulum (HP:0000015)2.50166796
16Short nail (HP:0001799)2.49986113
17Cervical subluxation (HP:0003308)2.49177554
18Abnormality of incisor morphology (HP:0011063)2.43762249
19Mitral stenosis (HP:0001718)2.40995353
20Abnormality of the nasal septum (HP:0000419)2.39311896
21Absent frontal sinuses (HP:0002688)2.36946916
22Subacute progressive viral hepatitis (HP:0006572)2.36443755
23Protrusio acetabuli (HP:0003179)2.36134323
24Vitreoretinal degeneration (HP:0000655)2.33797375
25Spinal rigidity (HP:0003306)2.30821569
26Cardiovascular calcification (HP:0011915)2.30139741
27Abnormality of the distal phalanges of the toes (HP:0010182)2.29447473
28Elbow flexion contracture (HP:0002987)2.28517312
29Recurrent abscess formation (HP:0002722)2.27196997
30Vertebral compression fractures (HP:0002953)2.25736805
31Atrophic scars (HP:0001075)2.24140027
32Thoracolumbar scoliosis (HP:0002944)2.22537331
33Flat capital femoral epiphysis (HP:0003370)2.20261091
34Overgrowth (HP:0001548)2.17187967
35Arterial tortuosity (HP:0005116)2.16031661
36Hematochezia (HP:0002573)2.13201106
37Abnormality of dentin (HP:0010299)2.11993723
38Tibial bowing (HP:0002982)2.10000106
39Curly hair (HP:0002212)2.08494630
40Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.07162048
41Peritonitis (HP:0002586)2.06377688
42Cerebral aneurysm (HP:0004944)2.05726211
43Hyperextensible skin (HP:0000974)2.02800900
44Ulnar bowing (HP:0003031)2.02386504
45Neonatal short-limb short stature (HP:0008921)2.01341795
46Soft skin (HP:0000977)2.00984659
47Short middle phalanx of the 5th finger (HP:0004220)2.00359618
48Vascular tortuosity (HP:0004948)2.00262668
49Abnormal delivery (HP:0001787)1.99498722
50Limited elbow extension (HP:0001377)1.98250619
51Prostate neoplasm (HP:0100787)1.96616180
52Papillary thyroid carcinoma (HP:0002895)1.95092730
53Aortic aneurysm (HP:0004942)1.91946515
54Abnormality of the umbilical cord (HP:0010881)1.91418117
55Mitral valve prolapse (HP:0001634)1.91357936
56Thick nail (HP:0001805)1.90191371
57Craniofacial hyperostosis (HP:0004493)1.89159582
58Knee flexion contracture (HP:0006380)1.86495459
59Vascular calcification (HP:0004934)1.86319989
60Persistence of primary teeth (HP:0006335)1.85465264
61Testicular neoplasm (HP:0010788)1.85328345
62Abnormality of the acetabulum (HP:0003170)1.85202903
63Flattened epiphyses (HP:0003071)1.84746660
64Gastrointestinal infarctions (HP:0005244)1.84129082
65Myocardial infarction (HP:0001658)1.83852913
66Vertebral arch anomaly (HP:0008438)1.82754165
67Recurrent bacterial skin infections (HP:0005406)1.82520090
68Abnormality of the fetal cardiovascular system (HP:0010948)1.82489225
69Abnormal umbilical cord blood vessels (HP:0011403)1.82489225
70Single umbilical artery (HP:0001195)1.82489225
71Insulin-resistant diabetes mellitus (HP:0000831)1.82279706
72Abnormal foot bone ossification (HP:0010675)1.81977776
73Abnormality of nail color (HP:0100643)1.81936586
74Mildly elevated creatine phosphokinase (HP:0008180)1.81707017
75Coarse hair (HP:0002208)1.80824128
76Flat acetabular roof (HP:0003180)1.80586432
77Volvulus (HP:0002580)1.80371403
78Abnormality of carpal bone ossification (HP:0006257)1.80018912
79Sparse lateral eyebrow (HP:0005338)1.79875113
80Exostoses (HP:0100777)1.79287029
81Advanced eruption of teeth (HP:0006288)1.78837905
82Popliteal pterygium (HP:0009756)1.78088065
83Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.77947781
84Asymmetry of the thorax (HP:0001555)1.77777936
85Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.76636575
86Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.75621736
87Mild short stature (HP:0003502)1.75563465
88Aplasia cutis congenita (HP:0001057)1.74563749
89Transitional cell carcinoma of the bladder (HP:0006740)1.74310990
90Genu recurvatum (HP:0002816)1.73561595
91Bowel diverticulosis (HP:0005222)1.72598454
92Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.72550700
93Joint laxity (HP:0001388)1.72541000
94Orchitis (HP:0100796)1.71538432
95Hypoplasia of the iris (HP:0007676)1.71357725
96Cubitus valgus (HP:0002967)1.71189830
97Delayed closure of the anterior fontanelle (HP:0001476)1.71184509
98Abnormality of the frontal sinuses (HP:0002687)1.70539431
99Deep philtrum (HP:0002002)1.70359700
100Follicular hyperkeratosis (HP:0007502)1.70073291
101Osteoarthritis (HP:0002758)1.68423380
102Bladder neoplasm (HP:0009725)1.67927825
103Bladder carcinoma (HP:0002862)1.67927825
104Trismus (HP:0000211)1.67566096
105Acute myeloid leukemia (HP:0004808)1.67259683
106Mesomelia (HP:0003027)1.66889265
107Osteolytic defects of the hand bones (HP:0009699)1.66349198
108Osteolytic defects of the phalanges of the hand (HP:0009771)1.66349198
109Rectal prolapse (HP:0002035)1.66337816
110Selective tooth agenesis (HP:0001592)1.66266211
111Nonimmune hydrops fetalis (HP:0001790)1.66201117
112Aneurysm (HP:0002617)1.65801604
113Gingivitis (HP:0000230)1.65785716
114Micronodular cirrhosis (HP:0001413)1.64973678
115Delayed cranial suture closure (HP:0000270)1.64927766
116Ankle contracture (HP:0006466)1.64395714
117Relative macrocephaly (HP:0004482)1.63252531
118Cutaneous melanoma (HP:0012056)1.63154152
119Wormian bones (HP:0002645)1.63111365
120Hypokinesia (HP:0002375)1.63069856
121Alopecia of scalp (HP:0002293)1.62951625
122Entropion (HP:0000621)1.62447531
123Tetraparesis (HP:0002273)1.62147224
124Type 1 muscle fiber predominance (HP:0003803)1.61707557
125Optic neuritis (HP:0100653)1.61575265
126Retrobulbar optic neuritis (HP:0100654)1.61575265
127Anhidrosis (HP:0000970)1.61375416
128Thyroid carcinoma (HP:0002890)1.61292984
129Upper limb muscle weakness (HP:0003484)1.61282196
130Dilatation of the ascending aorta (HP:0005111)1.61164857
131Coxa valga (HP:0002673)1.60391046
132Overlapping toe (HP:0001845)1.59251064
133Deviation of the thumb (HP:0009603)1.58744733
134Irregular epiphyses (HP:0010582)1.58549772
135Cranial hyperostosis (HP:0004437)1.58161140
136Spinal cord compression (HP:0002176)1.56719181
137Broad long bones (HP:0005622)1.56192179
138Spondylolisthesis (HP:0003302)1.54529536
139Platyspondyly (HP:0000926)1.54070490
140Chromsome breakage (HP:0040012)1.54038838
141Shallow orbits (HP:0000586)1.53078053
142Urethral obstruction (HP:0000796)1.52952711
143Blue sclerae (HP:0000592)1.52764768
144Abnormality of the vertebral endplates (HP:0005106)1.52504543
145Cystic hygroma (HP:0000476)1.52390248
146Abnormal hand bone ossification (HP:0010660)1.52203580
147Thin ribs (HP:0000883)1.52076531
148Abnormal cartilage morphology (HP:0002763)1.51973658
149Abnormalities of placenta or umbilical cord (HP:0001194)1.51555289
150Narrow palate (HP:0000189)1.51532020
151Enlarged epiphyses (HP:0010580)1.51327578
152Hypoplastic labia majora (HP:0000059)1.50990005
153Natal tooth (HP:0000695)1.50761742
154Long toe (HP:0010511)1.49943068
155Abnormal ossification of hand bones (HP:0005921)1.49160758
156Submucous cleft hard palate (HP:0000176)1.48186929
157Broad thumb (HP:0011304)1.47845200
158Abnormal vertebral ossification (HP:0100569)1.47019150
159Arterial thrombosis (HP:0004420)1.46996518
160Spinal cord lesions (HP:0100561)1.46889729
161Syringomyelia (HP:0003396)1.46889729
162Congenital sensorineural hearing impairment (HP:0008527)1.46388566

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS14.11842618
2TAOK33.27616620
3NUAK12.84014543
4EIF2AK32.78725844
5IRAK32.49416082
6MAP3K142.38546786
7EEF2K2.37127113
8MST42.29191496
9STK32.24825700
10CDK122.15824450
11EPHA22.11136452
12DDR22.07571149
13FRK2.05534276
14AKT31.93979479
15EPHA31.89276421
16IRAK11.82409054
17PBK1.73805798
18IRAK41.73208157
19EIF2AK11.70925256
20NLK1.69386013
21TRPM71.68174432
22STK101.64708949
23PKN21.58159207
24DMPK1.52254874
25NEK91.50234464
26PDGFRB1.48938283
27JAK11.48469762
28CDK91.44669210
29PDGFRA1.43316376
30IKBKB1.40320729
31WEE11.39070473
32BLK1.36669469
33MAP3K31.36333938
34STK38L1.35034334
35CHUK1.34996039
36PLK41.32476977
37BMPR21.32455593
38CSK1.31240015
39MAP3K91.30582379
40HIPK21.30494069
41PTK61.30021456
42INSRR1.28691283
43JAK31.23178522
44BRD41.22410272
45MAP3K61.22061821
46ERBB31.20335314
47ERBB41.16405081
48TBK11.12682161
49LATS21.09527530
50MYLK1.08854107
51ICK1.06045988
52FGFR31.06030779
53STK241.05932606
54PTK21.05396859
55CDK61.03968815
56PAK41.03668167
57EPHB11.02739423
58IKBKE1.01935684
59PAK20.99309521
60RPS6KA40.97848914
61WNK10.97066227
62STK40.95224651
63KSR10.92432296
64MAP3K20.91552595
65ERN10.91287550
66FLT30.86893730
67LMTK20.84745797
68TGFBR10.84129970
69MOS0.83020309
70MAP3K100.80889487
71TSSK60.80150945
72BMX0.78143736
73CAMK1D0.78028340
74TRIB30.77977627
75TGFBR20.77944266
76FGFR10.76484087
77ABL10.76355644
78KSR20.76080156
79TTN0.75912130
80STK380.75746182
81TRIM280.75521216
82CAMK1G0.75254360
83CLK10.73803090
84TYK20.73705389
85RPS6KB20.73493945
86BMPR1B0.73440249
87PNCK0.73352397
88BRSK20.71792910
89IRAK20.71759584
90EPHB20.71634645
91EIF2AK20.71130355
92TXK0.70598566
93TEC0.66127630
94MAPKAPK30.65404022
95MST1R0.64766432
96LRRK20.63382220
97SIK10.62837801
98FGFR40.62642218
99PAK30.62447329
100INSR0.59328834
101PIK3CA0.59264970
102PRKAA20.57683920
103MAP3K120.57441909
104DYRK30.57085337
105ITK0.56558228
106CDK70.55636174
107BRSK10.55570158
108MELK0.55345112
109MTOR0.54627900
110MARK30.54514326
111CHEK10.54356495
112MAP3K130.53875731
113PRKD20.52625994
114MET0.52102753
115NTRK10.52093076
116NME20.51510202
117BCR0.51180036
118RET0.51086777
119YES10.49805379
120MAP2K10.49494159
121ABL20.49432945
122FER0.49420437
123RPS6KB10.49128488
124LCK0.48695656
125MAP3K50.48179843
126CHEK20.48144140
127PRPF4B0.48110802
128SCYL20.47899356
129HCK0.47609091
130MAPK150.47499557
131AKT20.46644626
132PIK3CG0.46617210
133GSK3A0.46322834
134PIM10.45893223
135IGF1R0.45801296
136ROCK10.45706932
137ATM0.45128311
138PLK20.44984948
139EGFR0.44961132
140CDK80.44742845
141SMG10.44675298
142SIK30.44411151
143PLK30.44197246
144RIPK10.42543264
145MKNK20.41629962
146MAP3K10.41461838
147AKT10.40906668
148RIPK40.39085042
149TTK0.38819110
150MAP3K80.36290300

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur metabolism_Homo sapiens_hsa009202.06900099
2Thyroid cancer_Homo sapiens_hsa052162.02126580
3NF-kappa B signaling pathway_Homo sapiens_hsa040641.78500795
4ECM-receptor interaction_Homo sapiens_hsa045121.73988513
5Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.62692899
6Malaria_Homo sapiens_hsa051441.59976498
7Osteoclast differentiation_Homo sapiens_hsa043801.57930454
8Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.57454523
9Adherens junction_Homo sapiens_hsa045201.57254524
10NOD-like receptor signaling pathway_Homo sapiens_hsa046211.56004740
11Leishmaniasis_Homo sapiens_hsa051401.55153969
12TNF signaling pathway_Homo sapiens_hsa046681.53449755
13Toll-like receptor signaling pathway_Homo sapiens_hsa046201.47411018
14Pancreatic cancer_Homo sapiens_hsa052121.44675021
15Focal adhesion_Homo sapiens_hsa045101.38899762
16MicroRNAs in cancer_Homo sapiens_hsa052061.37084769
17Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.34006462
18Toxoplasmosis_Homo sapiens_hsa051451.32569739
19Small cell lung cancer_Homo sapiens_hsa052221.31588509
20Tight junction_Homo sapiens_hsa045301.30123995
21Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.25501524
22Dorso-ventral axis formation_Homo sapiens_hsa043201.25361371
23Graft-versus-host disease_Homo sapiens_hsa053321.24932659
24AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.23885923
25Maturity onset diabetes of the young_Homo sapiens_hsa049501.23822137
26Chronic myeloid leukemia_Homo sapiens_hsa052201.22885288
27Sphingolipid metabolism_Homo sapiens_hsa006001.22682985
28Prostate cancer_Homo sapiens_hsa052151.21305131
29Measles_Homo sapiens_hsa051621.16264043
30Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.15665142
31TGF-beta signaling pathway_Homo sapiens_hsa043501.15189049
32Jak-STAT signaling pathway_Homo sapiens_hsa046301.14466710
33Central carbon metabolism in cancer_Homo sapiens_hsa052301.14115617
34Prolactin signaling pathway_Homo sapiens_hsa049171.12032285
35Protein export_Homo sapiens_hsa030601.11962978
36Amoebiasis_Homo sapiens_hsa051461.11163673
37Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.10597659
38N-Glycan biosynthesis_Homo sapiens_hsa005101.08183154
39Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.08101656
40Glycosaminoglycan degradation_Homo sapiens_hsa005311.08039130
41Viral myocarditis_Homo sapiens_hsa054161.08011563
42Tuberculosis_Homo sapiens_hsa051521.06701388
43Cell cycle_Homo sapiens_hsa041101.06673376
44Proteoglycans in cancer_Homo sapiens_hsa052051.06581706
45Protein digestion and absorption_Homo sapiens_hsa049741.05553604
46Leukocyte transendothelial migration_Homo sapiens_hsa046701.04227010
47Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.03177654
48Hematopoietic cell lineage_Homo sapiens_hsa046401.03042472
49Legionellosis_Homo sapiens_hsa051341.01689338
50Apoptosis_Homo sapiens_hsa042101.01268278
51Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.00750314
52Insulin signaling pathway_Homo sapiens_hsa049101.00660267
53RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.00469521
54Renal cell carcinoma_Homo sapiens_hsa052110.99825346
55Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.99622153
56Vibrio cholerae infection_Homo sapiens_hsa051100.98463027
57Influenza A_Homo sapiens_hsa051640.98429328
58Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.97690173
59FoxO signaling pathway_Homo sapiens_hsa040680.97057180
60RNA transport_Homo sapiens_hsa030130.95783685
61p53 signaling pathway_Homo sapiens_hsa041150.95411996
62Hepatitis B_Homo sapiens_hsa051610.95374865
63Pertussis_Homo sapiens_hsa051330.94407303
64Hedgehog signaling pathway_Homo sapiens_hsa043400.94278404
65Chemokine signaling pathway_Homo sapiens_hsa040620.94180441
66B cell receptor signaling pathway_Homo sapiens_hsa046620.94047023
67Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.93961106
68Rheumatoid arthritis_Homo sapiens_hsa053230.93226060
69Lysosome_Homo sapiens_hsa041420.92856587
70Regulation of actin cytoskeleton_Homo sapiens_hsa048100.92732699
71Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.92686589
72Phagosome_Homo sapiens_hsa041450.92233387
73Antigen processing and presentation_Homo sapiens_hsa046120.91874250
74mRNA surveillance pathway_Homo sapiens_hsa030150.91735015
75Platelet activation_Homo sapiens_hsa046110.91499807
76Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.91260692
77Non-small cell lung cancer_Homo sapiens_hsa052230.90651745
78Vitamin B6 metabolism_Homo sapiens_hsa007500.89176475
79Herpes simplex infection_Homo sapiens_hsa051680.88847038
80Other glycan degradation_Homo sapiens_hsa005110.88675328
81Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.88043425
82Transcriptional misregulation in cancer_Homo sapiens_hsa052020.87364845
83Insulin resistance_Homo sapiens_hsa049310.87244846
84Type II diabetes mellitus_Homo sapiens_hsa049300.87136613
85Glioma_Homo sapiens_hsa052140.85402115
86AMPK signaling pathway_Homo sapiens_hsa041520.85022390
87PI3K-Akt signaling pathway_Homo sapiens_hsa041510.84655647
88Melanoma_Homo sapiens_hsa052180.84116575
89Allograft rejection_Homo sapiens_hsa053300.83704690
90Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.82499722
91Hepatitis C_Homo sapiens_hsa051600.82139721
92Shigellosis_Homo sapiens_hsa051310.81801664
93Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.81711834
94Type I diabetes mellitus_Homo sapiens_hsa049400.81706904
95Thyroid hormone signaling pathway_Homo sapiens_hsa049190.80765427
96Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.80100313
97Inositol phosphate metabolism_Homo sapiens_hsa005620.78918305
98One carbon pool by folate_Homo sapiens_hsa006700.78483080
99Intestinal immune network for IgA production_Homo sapiens_hsa046720.78393422
100Ovarian steroidogenesis_Homo sapiens_hsa049130.77553215
101Salmonella infection_Homo sapiens_hsa051320.77403013
102Sphingolipid signaling pathway_Homo sapiens_hsa040710.75944495
103T cell receptor signaling pathway_Homo sapiens_hsa046600.75024268
104mTOR signaling pathway_Homo sapiens_hsa041500.74102441
105Hippo signaling pathway_Homo sapiens_hsa043900.73868754
106ErbB signaling pathway_Homo sapiens_hsa040120.73307954
107Wnt signaling pathway_Homo sapiens_hsa043100.72288102
108HTLV-I infection_Homo sapiens_hsa051660.72272426
109Endometrial cancer_Homo sapiens_hsa052130.72047554
110Pathways in cancer_Homo sapiens_hsa052000.71262261
111Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.70209597
112Asthma_Homo sapiens_hsa053100.69750066
113Viral carcinogenesis_Homo sapiens_hsa052030.68696295
114Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.68672986
115Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.68021469
116Ether lipid metabolism_Homo sapiens_hsa005650.67565164
117HIF-1 signaling pathway_Homo sapiens_hsa040660.67285521
118Acute myeloid leukemia_Homo sapiens_hsa052210.64770247
119Ras signaling pathway_Homo sapiens_hsa040140.63888545
120Colorectal cancer_Homo sapiens_hsa052100.63220897
121Staphylococcus aureus infection_Homo sapiens_hsa051500.62900050
122Melanogenesis_Homo sapiens_hsa049160.61709358
123Neurotrophin signaling pathway_Homo sapiens_hsa047220.61212083
124Prion diseases_Homo sapiens_hsa050200.61106621
125Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.60536906
126Galactose metabolism_Homo sapiens_hsa000520.60086150
127Selenocompound metabolism_Homo sapiens_hsa004500.59811804
128Choline metabolism in cancer_Homo sapiens_hsa052310.59663880
129Basal transcription factors_Homo sapiens_hsa030220.59648207
130Longevity regulating pathway - mammal_Homo sapiens_hsa042110.59598713
131Bladder cancer_Homo sapiens_hsa052190.59418424
132Circadian rhythm_Homo sapiens_hsa047100.58816529
133Thyroid hormone synthesis_Homo sapiens_hsa049180.58010223
134Carbohydrate digestion and absorption_Homo sapiens_hsa049730.56803605
135Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.56702883
136Lysine degradation_Homo sapiens_hsa003100.55698805
137Glucagon signaling pathway_Homo sapiens_hsa049220.55068147
138Estrogen signaling pathway_Homo sapiens_hsa049150.53975147
139Phosphatidylinositol signaling system_Homo sapiens_hsa040700.53902994
140Non-homologous end-joining_Homo sapiens_hsa034500.52609509
141Dilated cardiomyopathy_Homo sapiens_hsa054140.52016719
142Nucleotide excision repair_Homo sapiens_hsa034200.47869666
143Basal cell carcinoma_Homo sapiens_hsa052170.45868319
144cGMP-PKG signaling pathway_Homo sapiens_hsa040220.45482949
145Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.44582981
146SNARE interactions in vesicular transport_Homo sapiens_hsa041300.44382660
147Adipocytokine signaling pathway_Homo sapiens_hsa049200.43559419

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