ACBD4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the acyl-coenzyme A binding domain containing protein family. All family members contain the conserved acyl-Coenzyme A binding domain, which binds acyl-CoA thiol esters. They are thought to play roles in acyl-CoA dependent lipid metabolism. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)5.72581564
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.72581564
3L-phenylalanine metabolic process (GO:0006558)5.71768549
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.71768549
5triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.34868359
6lysine catabolic process (GO:0006554)5.05569920
7lysine metabolic process (GO:0006553)5.05569920
8cysteine metabolic process (GO:0006534)5.04858274
9alpha-linolenic acid metabolic process (GO:0036109)5.01062908
10aromatic amino acid family catabolic process (GO:0009074)5.00844574
11fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.91755302
12sulfur amino acid catabolic process (GO:0000098)4.86937312
13glyoxylate metabolic process (GO:0046487)4.79661822
14regulation of triglyceride catabolic process (GO:0010896)4.60692389
15valine metabolic process (GO:0006573)4.53331077
16amino-acid betaine metabolic process (GO:0006577)4.43391725
17indole-containing compound catabolic process (GO:0042436)4.40498358
18indolalkylamine catabolic process (GO:0046218)4.40498358
19tryptophan catabolic process (GO:0006569)4.40498358
20kynurenine metabolic process (GO:0070189)4.34878806
21fatty acid beta-oxidation (GO:0006635)4.32674356
22bile acid biosynthetic process (GO:0006699)4.32330485
23urea metabolic process (GO:0019627)4.30021280
24urea cycle (GO:0000050)4.30021280
25serine family amino acid catabolic process (GO:0009071)4.28988421
26acetyl-CoA metabolic process (GO:0006084)4.20094334
27drug catabolic process (GO:0042737)4.15188531
28complement activation, alternative pathway (GO:0006957)4.14536823
29homocysteine metabolic process (GO:0050667)4.13212257
30tryptophan metabolic process (GO:0006568)4.11963299
31regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.11272258
32short-chain fatty acid metabolic process (GO:0046459)4.10295075
33antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.08978721
34fatty acid oxidation (GO:0019395)4.08358501
35antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.05430660
36acylglycerol homeostasis (GO:0055090)4.03054550
37triglyceride homeostasis (GO:0070328)4.03054550
38high-density lipoprotein particle remodeling (GO:0034375)4.02407684
39lipid oxidation (GO:0034440)4.02253352
40plasma lipoprotein particle clearance (GO:0034381)4.02031308
412-oxoglutarate metabolic process (GO:0006103)3.99947104
42nitrogen cycle metabolic process (GO:0071941)3.99623551
43positive regulation of fatty acid beta-oxidation (GO:0032000)3.97157736
44fatty acid catabolic process (GO:0009062)3.96312978
45antigen processing and presentation of endogenous antigen (GO:0019883)3.87799811
46positive regulation of lipid catabolic process (GO:0050996)3.86315331
47alpha-amino acid catabolic process (GO:1901606)3.86238267
48drug transmembrane transport (GO:0006855)3.81061763
49biotin metabolic process (GO:0006768)3.81057702
50carnitine metabolic process (GO:0009437)3.81013910
51cellular ketone body metabolic process (GO:0046950)3.80767279
52arginine metabolic process (GO:0006525)3.77883394
53regulation of cholesterol homeostasis (GO:2000188)3.76868004
54monocarboxylic acid catabolic process (GO:0072329)3.75842315
55low-density lipoprotein particle clearance (GO:0034383)3.75097070
56regulation of protein activation cascade (GO:2000257)3.75083474
57cellular amino acid catabolic process (GO:0009063)3.74406264
58bile acid metabolic process (GO:0008206)3.74170219
59positive regulation of fatty acid oxidation (GO:0046321)3.73784826
60exogenous drug catabolic process (GO:0042738)3.73167623
61reverse cholesterol transport (GO:0043691)3.72979575
62peptidyl-glutamic acid carboxylation (GO:0017187)3.72502752
63protein carboxylation (GO:0018214)3.72502752
64GDP-mannose metabolic process (GO:0019673)3.70766405
65fatty acid transmembrane transport (GO:1902001)3.70398674
66cellular modified amino acid catabolic process (GO:0042219)3.70176089
67regulation of cholesterol esterification (GO:0010872)3.69545683
68omega-hydroxylase P450 pathway (GO:0097267)3.68319628
69aromatic amino acid family metabolic process (GO:0009072)3.67826404
70ethanol metabolic process (GO:0006067)3.67685872
71branched-chain amino acid metabolic process (GO:0009081)3.67639600
72ethanol oxidation (GO:0006069)3.66233260
73regulation of sequestering of triglyceride (GO:0010889)3.65209343
74phospholipid efflux (GO:0033700)3.64593150
75urate metabolic process (GO:0046415)3.64236841
76aspartate family amino acid catabolic process (GO:0009068)3.62961204
77protein-lipid complex remodeling (GO:0034368)3.61813130
78macromolecular complex remodeling (GO:0034367)3.61813130
79plasma lipoprotein particle remodeling (GO:0034369)3.61813130
80branched-chain amino acid catabolic process (GO:0009083)3.61253705
81triglyceride catabolic process (GO:0019433)3.60175592
82glutamate metabolic process (GO:0006536)3.59759835
83regulation of complement activation (GO:0030449)3.59320213
84negative regulation of fibrinolysis (GO:0051918)3.59281040
85acylglycerol catabolic process (GO:0046464)3.57543227
86neutral lipid catabolic process (GO:0046461)3.57543227
87organic acid catabolic process (GO:0016054)3.56033779
88carboxylic acid catabolic process (GO:0046395)3.56033779
89coenzyme catabolic process (GO:0009109)3.52620731
90very-low-density lipoprotein particle assembly (GO:0034379)3.50394421
91tyrosine metabolic process (GO:0006570)3.47727394
92negative regulation of cholesterol transport (GO:0032375)3.47657489
93negative regulation of sterol transport (GO:0032372)3.47657489
94intestinal cholesterol absorption (GO:0030299)3.47415419
95regulation of fatty acid beta-oxidation (GO:0031998)3.47003600
96blood coagulation, intrinsic pathway (GO:0007597)3.46960398
97mannose metabolic process (GO:0006013)3.45276815
98arginine catabolic process (GO:0006527)3.44575384
99alkaloid metabolic process (GO:0009820)3.44300987
100tricarboxylic acid metabolic process (GO:0072350)3.41546275
101positive regulation of triglyceride lipase activity (GO:0061365)3.39358056
102positive regulation of lipoprotein lipase activity (GO:0051006)3.39358056
103oxaloacetate metabolic process (GO:0006107)3.38946533
104serine family amino acid metabolic process (GO:0009069)3.38939496
105carnitine shuttle (GO:0006853)3.37222935
106NADH metabolic process (GO:0006734)3.36730361
107regulation of cytokine production involved in inflammatory response (GO:1900015)3.36663416
108drug metabolic process (GO:0017144)3.35752706
109regulation of fibrinolysis (GO:0051917)3.35333864
110positive regulation of triglyceride metabolic process (GO:0090208)3.34097694
111dicarboxylic acid biosynthetic process (GO:0043650)3.33601122
112flavonoid metabolic process (GO:0009812)3.32193037
113epoxygenase P450 pathway (GO:0019373)3.28639387
114fat-soluble vitamin biosynthetic process (GO:0042362)3.26514035
115positive regulation of fatty acid metabolic process (GO:0045923)3.25892708
116ketone body metabolic process (GO:1902224)3.25380335
117plasma lipoprotein particle organization (GO:0071827)3.24948763
118antigen processing and presentation via MHC class Ib (GO:0002475)3.24761135
119bile acid and bile salt transport (GO:0015721)3.24275098
120diacylglycerol metabolic process (GO:0046339)3.23692902
121transepithelial transport (GO:0070633)3.20599712
122proline metabolic process (GO:0006560)3.19131879
123protein activation cascade (GO:0072376)3.18067736
124complement activation, classical pathway (GO:0006958)3.17060801
125cholesterol efflux (GO:0033344)3.15134919
126regulation of guanylate cyclase activity (GO:0031282)3.11131839
127hormone catabolic process (GO:0042447)3.08647456
128regulation of plasminogen activation (GO:0010755)3.08496336
129S-adenosylmethionine metabolic process (GO:0046500)3.07975484
130positive regulation of fatty acid biosynthetic process (GO:0045723)3.06192249
131phenylpropanoid metabolic process (GO:0009698)3.02682782
132peptidyl-glutamic acid modification (GO:0018200)3.02406474
133complement activation (GO:0006956)3.02197811
134protein-lipid complex subunit organization (GO:0071825)3.00935552
135positive regulation of antigen processing and presentation (GO:0002579)2.98625419
136regulation of triglyceride metabolic process (GO:0090207)2.97796711
137regulation of cholesterol metabolic process (GO:0090181)2.91055421
138plasma lipoprotein particle assembly (GO:0034377)2.90122724
139drug transport (GO:0015893)2.87794970
140oxidative demethylation (GO:0070989)2.87271116
141acute-phase response (GO:0006953)2.86590389
142negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.86045138
143response to misfolded protein (GO:0051788)2.84560195
144regulation of humoral immune response (GO:0002920)2.83954930
145fibrinolysis (GO:0042730)2.83662772
146negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.78587684
147cellular glucuronidation (GO:0052695)2.77569260
148regulation of lipoprotein particle clearance (GO:0010984)2.76962217
149uronic acid metabolic process (GO:0006063)2.75360281
150glucuronate metabolic process (GO:0019585)2.75360281
151intestinal absorption (GO:0050892)2.75181351
152imidazole-containing compound metabolic process (GO:0052803)2.72517980
153regulation of hydrogen peroxide metabolic process (GO:0010310)2.68544406
154positive regulation of guanylate cyclase activity (GO:0031284)2.64665067

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse8.87806777
2* PPARG_19300518_ChIP-PET_3T3-L1_Mouse7.78268614
3* RXR_22158963_ChIP-Seq_LIVER_Mouse6.50077556
4* PPARA_22158963_ChIP-Seq_LIVER_Mouse5.73961658
5LXR_22158963_ChIP-Seq_LIVER_Mouse5.07279256
6EGR1_23403033_ChIP-Seq_LIVER_Mouse4.17644518
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.16571051
8* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.56499327
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.41012628
10CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.19290433
11IRF8_22096565_ChIP-ChIP_GC-B_Human3.06973803
12VDR_21846776_ChIP-Seq_THP-1_Human3.00923799
13CLOCK_20551151_ChIP-Seq_293T_Human2.58862174
14CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.57408023
15TP63_17297297_ChIP-ChIP_HaCaT_Human2.23620825
16CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.21065342
17E2F1_20622854_ChIP-Seq_HELA_Human2.20860470
18RARG_19884340_ChIP-ChIP_MEFs_Mouse2.08495615
19ZNF263_19887448_ChIP-Seq_K562_Human2.05076246
20PHF8_20622854_ChIP-Seq_HELA_Human2.00996221
21HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.92976500
22ELF1_20517297_ChIP-Seq_JURKAT_Human1.91951402
23ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.83009648
24TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.82036249
25* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.80447674
26EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.79170347
27THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.77898911
28MAF_26560356_Chip-Seq_TH2_Human1.76150933
29* RARB_24833708_ChIP-Seq_LIVER_Mouse1.74381014
30CTCF_27219007_Chip-Seq_ERYTHROID_Human1.67821191
31KDM2B_26808549_Chip-Seq_SUP-B15_Human1.64924923
32GATA1_22025678_ChIP-Seq_K562_Human1.62376199
33* SA1_27219007_Chip-Seq_Bcells_Human1.61705699
34MAF_26560356_Chip-Seq_TH1_Human1.60689531
35* CTCF_20526341_ChIP-Seq_ESCs_Human1.60349051
36YY1_22570637_ChIP-Seq_MALME-3M_Human1.60121783
37SA1_27219007_Chip-Seq_ERYTHROID_Human1.59514667
38RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.57629995
39ESR2_21235772_ChIP-Seq_MCF-7_Human1.56004418
40KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.53586220
41VDR_24763502_ChIP-Seq_THP-1_Human1.52786602
42MYC_22102868_ChIP-Seq_BL_Human1.52604235
43EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.50404564
44TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.48959467
45ERA_21632823_ChIP-Seq_H3396_Human1.48549711
46UTX_26944678_Chip-Seq_JUKART_Human1.47593817
47FOXA2_19822575_ChIP-Seq_HepG2_Human1.45451155
48IKZF1_21737484_ChIP-ChIP_HCT116_Human1.43003407
49GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.42753506
50KDM2B_26808549_Chip-Seq_DND41_Human1.42469262
51RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.41212393
52SRY_22984422_ChIP-ChIP_TESTIS_Rat1.40938060
53SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.40205225
54P300_27268052_Chip-Seq_Bcells_Human1.39179541
55RAC3_21632823_ChIP-Seq_H3396_Human1.34522706
56* CTCF_21964334_Chip-Seq_Bcells_Human1.33895678
57LXR_22292898_ChIP-Seq_THP-1_Human1.33193083
58* FOXP1_21924763_ChIP-Seq_HESCs_Human1.33176641
59MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.32647739
60* CTCF_26484167_Chip-Seq_Bcells_Mouse1.30944918
61STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.30026479
62* CTCF_21964334_ChIP-Seq_BJAB-B_Human1.26409938
63HNF4A_19822575_ChIP-Seq_HepG2_Human1.24418851
64TCF7_22412390_ChIP-Seq_EML_Mouse1.24091446
65SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.23693147
66TRIM28_21343339_ChIP-Seq_HEK293_Human1.23300105
67LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.22945694
68PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.22007437
69DROSHA_22980978_ChIP-Seq_HELA_Human1.21813223
70SOX2_27498859_Chip-Seq_STOMACH_Mouse1.19571900
71SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.19274585
72SPI1_20517297_ChIP-Seq_HL60_Human1.19094167
73PU.1_20513432_ChIP-Seq_Bcells_Mouse1.19067626
74STAT6_21828071_ChIP-Seq_BEAS2B_Human1.18384158
75CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.17977400
76OCT4_19829295_ChIP-Seq_ESCs_Human1.17926172
77ETS1_21867929_ChIP-Seq_TH2_Mouse1.16953494
78MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.16893246
79CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.15216670
80NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.13442764
81JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.11359695
82ESR1_21235772_ChIP-Seq_MCF-7_Human1.11341671
83PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.09527066
84ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.08309711
85MYC_19829295_ChIP-Seq_ESCs_Human1.07714073
86NANOG_20526341_ChIP-Seq_ESCs_Human1.07112836
87TP53_22127205_ChIP-Seq_IMR90_Human1.06696821
88NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.06322110
89TAF2_19829295_ChIP-Seq_ESCs_Human1.06203346
90RUNX1_22412390_ChIP-Seq_EML_Mouse1.05906729
91OCT4_20526341_ChIP-Seq_ESCs_Human1.05070880
92CDX2_20551321_ChIP-Seq_CACO-2_Human1.04936975
93RACK7_27058665_Chip-Seq_MCF-7_Human1.04378055
94TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.03767424
95SOX2_21211035_ChIP-Seq_LN229_Human1.03126984
96BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.01586317
97ERG_21242973_ChIP-ChIP_JURKAT_Human1.00311124
98GATA4_25053715_ChIP-Seq_YYC3_Human0.98710525
99PPAR_26484153_Chip-Seq_NCI-H1993_Human0.97654877
100FOXO3_23340844_ChIP-Seq_DLD1_Human0.96355858
101TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.94350575
102CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.93966768
103* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.93731736
104TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.92766103
105ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.91011751
106GATA1_19941826_ChIP-Seq_K562_Human0.90354425
107MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.88974801
108SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.88846077
109STAT3_1855785_ChIP-Seq_MESCs_Mouse0.84259681
110RXRA_24833708_ChIP-Seq_LIVER_Mouse0.83637403
111TBX20_22328084_ChIP-Seq_HEART_Mouse0.82100426
112TBX20_22080862_ChIP-Seq_HEART_Mouse0.82100426
113ESR1_20079471_ChIP-ChIP_T-47D_Human0.81572917
114DNAJC2_21179169_ChIP-ChIP_NT2_Human0.81510103
115PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.81208034
116IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.80720501
117GATA2_19941826_ChIP-Seq_K562_Human0.79858727
118SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.79603097
119ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.77890173
120ATF3_27146783_Chip-Seq_COLON_Human0.77368625
121SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.77361612
122* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.76797627
123SOX2_20726797_ChIP-Seq_SW620_Human0.76633258
124KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.74854978
125GATA1_19941827_ChIP-Seq_MEL_Mouse0.74574718
126EGR1_19032775_ChIP-ChIP_M12_Human0.73691423
127PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.73674109
128* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.73164687
129AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.72415518
130BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.72378064
131PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.71652767
132CREB1_26743006_Chip-Seq_LNCaP_Human0.70164124
133P63_26484246_Chip-Seq_KERATINOCYTES_Human0.69463015
134PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.69003140
135P68_20966046_ChIP-Seq_HELA_Human0.67062055
136RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.65993110
137TET1_21451524_ChIP-Seq_MESCs_Mouse0.65867083
138NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.65679853
139STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.65629027
140ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.65191971
141TP63_22573176_ChIP-Seq_HFKS_Human0.64532752
142GATA6_25053715_ChIP-Seq_YYC3_Human0.64511043
143* CTCF_27219007_Chip-Seq_Bcells_Human0.63121873
144BCOR_27268052_Chip-Seq_Bcells_Human0.63042999
145NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.62229398
146NRF2_20460467_ChIP-Seq_MEFs_Mouse0.62229398
147GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.62087232
148P300_27058665_Chip-Seq_ZR-75-30cells_Human0.61707800
149BCL6_27268052_Chip-Seq_Bcells_Human0.61595002
150EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.60893336
151PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.60259719
152SOX9_24532713_ChIP-Seq_HFSC_Mouse0.59817224
153SMC4_20622854_ChIP-Seq_HELA_Human0.59630678
154RUNX1_27514584_Chip-Seq_MCF-7_Human0.59365386
155HIF1A_21447827_ChIP-Seq_MCF-7_Human0.58802630
156CEBPB_22108803_ChIP-Seq_LS180_Human0.58648124
157AUTS2_25519132_ChIP-Seq_293T-REX_Human0.58217473
158RARA_24833708_ChIP-Seq_LIVER_Mouse0.58162850
159BCAT_22108803_ChIP-Seq_LS180_Human0.57222949
160ELK3_25401928_ChIP-Seq_HUVEC_Human0.57089681

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis6.94305374
2MP0002139_abnormal_hepatobiliary_system6.82051753
3MP0005365_abnormal_bile_salt4.79863897
4MP0005085_abnormal_gallbladder_physiolo4.64437054
5MP0008875_abnormal_xenobiotic_pharmacok3.85799996
6MP0010329_abnormal_lipoprotein_level3.63560980
7MP0009840_abnormal_foam_cell3.07954440
8MP0003252_abnormal_bile_duct3.01690300
9MP0005332_abnormal_amino_acid2.99796673
10MP0003806_abnormal_nucleotide_metabolis2.98688477
11MP0005670_abnormal_white_adipose2.94154517
12MP0003191_abnormal_cellular_cholesterol2.58861482
13MP0001986_abnormal_taste_sensitivity2.38772806
14MP0004019_abnormal_vitamin_homeostasis2.37040946
15MP0001666_abnormal_nutrient_absorption2.31161792
16MP0003195_calcinosis2.29709280
17MP0002118_abnormal_lipid_homeostasis2.26582032
18MP0004130_abnormal_muscle_cell2.18923913
19MP0005666_abnormal_adipose_tissue2.09400586
20MP0005083_abnormal_biliary_tract2.05910004
21MP0000609_abnormal_liver_physiology1.99718688
22MP0003172_abnormal_lysosome_physiology1.96284714
23MP0002837_dystrophic_cardiac_calcinosis1.81944891
24MP0003705_abnormal_hypodermis_morpholog1.80432924
25MP0009643_abnormal_urine_homeostasis1.76825078
26MP0005319_abnormal_enzyme/_coenzyme1.75893654
27MP0005584_abnormal_enzyme/coenzyme_acti1.68526192
28MP0005167_abnormal_blood-brain_barrier1.66231291
29MP0003436_decreased_susceptibility_to1.65279783
30MP0001348_abnormal_lacrimal_gland1.58778778
31MP0002876_abnormal_thyroid_physiology1.57900590
32MP0002138_abnormal_hepatobiliary_system1.56951362
33MP0004185_abnormal_adipocyte_glucose1.56869534
34MP0002971_abnormal_brown_adipose1.55028482
35MP0000685_abnormal_immune_system1.51729025
36MP0001764_abnormal_homeostasis1.44282847
37MP0005375_adipose_tissue_phenotype1.41927911
38MP0003186_abnormal_redox_activity1.41217063
39MP0002254_reproductive_system_inflammat1.39829374
40MP0003879_abnormal_hair_cell1.38681979
41MP0003656_abnormal_erythrocyte_physiolo1.38035329
42MP0001790_abnormal_immune_system1.35222307
43MP0005387_immune_system_phenotype1.35222307
44MP0005535_abnormal_body_temperature1.33442352
45MP0002933_joint_inflammation1.30045611
46MP0006036_abnormal_mitochondrial_physio1.30009220
47MP0001873_stomach_inflammation1.26506466
48MP0005334_abnormal_fat_pad1.25974189
49MP0001756_abnormal_urination1.25526341
50MP0003183_abnormal_peptide_metabolism1.24463232
51MP0005025_abnormal_response_to1.17933492
52MP0005636_abnormal_mineral_homeostasis1.17777199
53MP0002796_impaired_skin_barrier1.17063470
54MP0004043_abnormal_pH_regulation1.15616273
55MP0009785_altered_susceptibility_to1.14272357
56MP0010234_abnormal_vibrissa_follicle1.14184364
57MP0003878_abnormal_ear_physiology1.12962480
58MP0005377_hearing/vestibular/ear_phenot1.12962480
59MP0009115_abnormal_fat_cell1.10890411
60MP0001849_ear_inflammation1.09309795
61MP0001502_abnormal_circadian_rhythm1.09082237
62MP0010155_abnormal_intestine_physiology1.08630495
63MP0002078_abnormal_glucose_homeostasis1.07934838
64MP0005671_abnormal_response_to1.05157430
65MP0000604_amyloidosis1.04537894
66MP0001800_abnormal_humoral_immune1.04506666
67MP0005275_abnormal_skin_tensile1.01463026
68MP0003329_amyloid_beta_deposits0.99602709
69MP0005448_abnormal_energy_balance0.98425431
70MP0002723_abnormal_immune_serum0.98356907
71MP0004147_increased_porphyrin_level0.97372256
72MP0005174_abnormal_tail_pigmentation0.95786724
73MP0000013_abnormal_adipose_tissue0.94966343
74MP0009333_abnormal_splenocyte_physiolog0.94016323
75MP0001835_abnormal_antigen_presentation0.94010696
76MP0002638_abnormal_pupillary_reflex0.93899336
77MP0008438_abnormal_cutaneous_collagen0.93552436
78MP0002136_abnormal_kidney_physiology0.92182974
79MP0000598_abnormal_liver_morphology0.91808713
80MP0003011_delayed_dark_adaptation0.91149321
81MP0005551_abnormal_eye_electrophysiolog0.90404088
82MP0009764_decreased_sensitivity_to0.90224435
83MP0005451_abnormal_body_composition0.89081285
84MP0002735_abnormal_chemical_nociception0.88622294
85MP0005171_absent_coat_pigmentation0.88173689
86MP0002970_abnormal_white_adipose0.86543469
87MP0003868_abnormal_feces_composition0.85348609
88MP0002419_abnormal_innate_immunity0.85152166
89MP0008961_abnormal_basal_metabolism0.85016647
90MP0005000_abnormal_immune_tolerance0.84675661
91MP0000003_abnormal_adipose_tissue0.84666563
92MP0003303_peritoneal_inflammation0.84487960
93MP0001661_extended_life_span0.84452088
94MP0009642_abnormal_blood_homeostasis0.83267227
95MP0001845_abnormal_inflammatory_respons0.82787520
96MP0002132_abnormal_respiratory_system0.82228819
97MP0003690_abnormal_glial_cell0.81262948
98MP0005647_abnormal_sex_gland0.81086431
99MP0001765_abnormal_ion_homeostasis0.80920777
100MP0001663_abnormal_digestive_system0.80540607
101MP0003646_muscle_fatigue0.79410078
102MP0005410_abnormal_fertilization0.77292262
103MP0005645_abnormal_hypothalamus_physiol0.76329003
104MP0002420_abnormal_adaptive_immunity0.74773541
105MP0001819_abnormal_immune_cell0.74582583
106MP0002452_abnormal_antigen_presenting0.74087940
107MP0000230_abnormal_systemic_arterial0.72760027
108MP0003136_yellow_coat_color0.71653743
109MP0005376_homeostasis/metabolism_phenot0.71293351
110MP0009763_increased_sensitivity_to0.69533825
111MP0002822_catalepsy0.69032351
112MP0005058_abnormal_lysosome_morphology0.68842962
113MP0005266_abnormal_metabolism0.68339072
114MP0005084_abnormal_gallbladder_morpholo0.67812723
115MP0000249_abnormal_blood_vessel0.66879532
116MP0003137_abnormal_impulse_conducting0.66472513
117MP0003953_abnormal_hormone_level0.64590311
118MP0008874_decreased_physiological_sensi0.64074303
119MP0008469_abnormal_protein_level0.64046127
120MP0008872_abnormal_physiological_respon0.63809570
121MP0002060_abnormal_skin_morphology0.62569175
122MP0002909_abnormal_adrenal_gland0.60800617
123MP0009780_abnormal_chondrocyte_physiolo0.59917818
124MP0002168_other_aberrant_phenotype0.59766370
125MP0003959_abnormal_lean_body0.59457657
126MP0006035_abnormal_mitochondrial_morpho0.58700868
127MP0008775_abnormal_heart_ventricle0.58197367
128MP0003075_altered_response_to0.58050154
129MP0009765_abnormal_xenobiotic_induced0.58014834
130MP0005330_cardiomyopathy0.57211308
131MP0006138_congestive_heart_failure0.56929969
132MP0001881_abnormal_mammary_gland0.56313147
133MP0003638_abnormal_response/metabolism_0.52535817
134MP0004858_abnormal_nervous_system0.52342007
135MP0005452_abnormal_adipose_tissue0.52250797
136MP0005501_abnormal_skin_physiology0.51010570
137MP0009697_abnormal_copulation0.50798650
138MP0002269_muscular_atrophy0.50306049
139MP0003300_gastrointestinal_ulcer0.50093948
140MP0002332_abnormal_exercise_endurance0.48867134
141MP0005385_cardiovascular_system_phenoty0.44950348
142MP0001544_abnormal_cardiovascular_syste0.44950348
143MP0003724_increased_susceptibility_to0.42626647

Predicted human phenotypes

RankGene SetZ-score
1Xanthomatosis (HP:0000991)5.52139441
2Hyperglycinuria (HP:0003108)5.45428426
3Abnormality of aromatic amino acid family metabolism (HP:0004338)5.23833038
4Deep venous thrombosis (HP:0002625)4.80067464
5Abnormality of serine family amino acid metabolism (HP:0010894)4.78885220
6Abnormality of glycine metabolism (HP:0010895)4.78885220
7Abnormality of glutamine family amino acid metabolism (HP:0010902)4.77908309
8Intrahepatic cholestasis (HP:0001406)4.71853850
9Hyperlipoproteinemia (HP:0010980)4.64227513
10Abnormality of monocarboxylic acid metabolism (HP:0010996)4.46835632
11Ketosis (HP:0001946)4.44370121
12Hyperammonemia (HP:0001987)4.41631654
13Mesangial abnormality (HP:0001966)4.37430604
14Hyperglycinemia (HP:0002154)4.17732808
15Complement deficiency (HP:0004431)4.14174332
16Hypobetalipoproteinemia (HP:0003563)4.13725670
17Abnormality of fatty-acid metabolism (HP:0004359)3.86050888
18Ketoacidosis (HP:0001993)3.85233476
19Hypoglycemic coma (HP:0001325)3.78549249
20Prolonged partial thromboplastin time (HP:0003645)3.71509058
21Testicular atrophy (HP:0000029)3.67500696
22Hypolipoproteinemia (HP:0010981)3.66352107
23Hypoalphalipoproteinemia (HP:0003233)3.65437011
24Gout (HP:0001997)3.61526134
25Epidermoid cyst (HP:0200040)3.58970188
26Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.56114060
27Hydroxyprolinuria (HP:0003080)3.44202157
28Abnormality of proline metabolism (HP:0010907)3.44202157
29Congenital stationary night blindness (HP:0007642)3.42726855
30Abnormality of aspartate family amino acid metabolism (HP:0010899)3.38911361
31Abnormality of purine metabolism (HP:0004352)3.38224843
32Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.28754307
33Abnormality of sulfur amino acid metabolism (HP:0004339)3.27225039
34Abnormality of polysaccharide metabolism (HP:0011012)3.18820486
35Abnormality of glycosaminoglycan metabolism (HP:0004371)3.18820486
36Abnormality of mucopolysaccharide metabolism (HP:0011020)3.18820486
37Dicarboxylic aciduria (HP:0003215)3.16457150
38Abnormality of dicarboxylic acid metabolism (HP:0010995)3.16457150
39Birth length less than 3rd percentile (HP:0003561)3.16165570
40Abnormality of complement system (HP:0005339)2.96165730
41Hypercholesterolemia (HP:0003124)2.95246378
42Abnormality of nucleobase metabolism (HP:0010932)2.94570180
43Attenuation of retinal blood vessels (HP:0007843)2.90367811
44Metabolic acidosis (HP:0001942)2.89691542
45Urinary glycosaminoglycan excretion (HP:0003541)2.89454552
46Mucopolysacchariduria (HP:0008155)2.89454552
47Abnormality of the common coagulation pathway (HP:0010990)2.88728834
48Breast hypoplasia (HP:0003187)2.85652003
49Glomerulonephritis (HP:0000099)2.84339529
50Joint hemorrhage (HP:0005261)2.76872803
51Fat malabsorption (HP:0002630)2.74223444
52Hyperbilirubinemia (HP:0002904)2.73387958
53Generalized aminoaciduria (HP:0002909)2.73255075
54Thin bony cortex (HP:0002753)2.72493481
55Abnormality of serum amino acid levels (HP:0003112)2.71596842
56Lethargy (HP:0001254)2.70634359
57Increased purine levels (HP:0004368)2.67613295
58Hyperuricemia (HP:0002149)2.67613295
59Myocardial infarction (HP:0001658)2.67612119
60Delayed CNS myelination (HP:0002188)2.65651708
61Hypertriglyceridemia (HP:0002155)2.62447059
62Decreased electroretinogram (ERG) amplitude (HP:0000654)2.60938991
63Myoglobinuria (HP:0002913)2.60776183
64Akinesia (HP:0002304)2.59668533
65Proximal tubulopathy (HP:0000114)2.56905171
66Malnutrition (HP:0004395)2.55526066
67Widely patent fontanelles and sutures (HP:0004492)2.55144363
68Microretrognathia (HP:0000308)2.52071103
69Abnormality of methionine metabolism (HP:0010901)2.51969616
70Abnormality of the intrinsic pathway (HP:0010989)2.47550612
71Vomiting (HP:0002013)2.47255610
72Skin nodule (HP:0200036)2.44370249
73Cholelithiasis (HP:0001081)2.43170324
74Oligomenorrhea (HP:0000876)2.42661336
75Nausea (HP:0002018)2.39821277
76Hepatocellular carcinoma (HP:0001402)2.39772748
77Neonatal onset (HP:0003623)2.35967367
78Late onset (HP:0003584)2.35285418
79Sensorimotor neuropathy (HP:0007141)2.33598572
80Spontaneous abortion (HP:0005268)2.32627631
81Abnormal gallbladder morphology (HP:0012437)2.32223899
82Nephritis (HP:0000123)2.31989276
83Acanthocytosis (HP:0001927)2.31800160
84Cerebral edema (HP:0002181)2.30913871
85Vascular calcification (HP:0004934)2.30857208
86Recurrent gram-negative bacterial infections (HP:0005420)2.30001844
87Cerebral palsy (HP:0100021)2.27275129
88Pancreatitis (HP:0001733)2.26361926
89Hypophosphatemic rickets (HP:0004912)2.25686871
90Renal Fanconi syndrome (HP:0001994)2.24532495
91Acanthosis nigricans (HP:0000956)2.24351524
92Increased intramyocellular lipid droplets (HP:0012240)2.22864051
93Joint stiffness (HP:0001387)2.21290762
94Ileus (HP:0002595)2.20526609
95Purpura (HP:0000979)2.19627450
96Decreased central vision (HP:0007663)2.19501339
97Conjugated hyperbilirubinemia (HP:0002908)2.18672629
98Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.18540761
99Annular pancreas (HP:0001734)2.18156675
100Abnormal cartilage morphology (HP:0002763)2.17234254
101Irritability (HP:0000737)2.16376001
102Cardiovascular calcification (HP:0011915)2.16308252
103Systemic lupus erythematosus (HP:0002725)2.15065420
104Abnormal urine phosphate concentration (HP:0012599)2.12389095
105Abnormality of urine glucose concentration (HP:0011016)2.10794694
106Glycosuria (HP:0003076)2.10794694
107Dysostosis multiplex (HP:0000943)2.10022356
108Spastic diplegia (HP:0001264)2.08438668
109Pustule (HP:0200039)2.07303966
110Abnormality of pyrimidine metabolism (HP:0004353)2.07260854
111Cholecystitis (HP:0001082)2.04800530
112Abnormal gallbladder physiology (HP:0012438)2.04800530
113Right ventricular cardiomyopathy (HP:0011663)2.04696508
114Vaginal fistula (HP:0004320)2.04375618
115Hemorrhage of the eye (HP:0011885)2.03787954
116Facial diplegia (HP:0001349)2.03506576
117Hypochromic anemia (HP:0001931)2.02869190
118Myositis (HP:0100614)2.01258915
119Gastrointestinal infarctions (HP:0005244)2.00074067
120Rib fusion (HP:0000902)1.95261140
121Amyloidosis (HP:0011034)1.95172588
122Brushfield spots (HP:0001088)1.94938503
123Alkalosis (HP:0001948)1.93682034
124Abnormal albumin level (HP:0012116)1.93574907
125Hypoalbuminemia (HP:0003073)1.93574907
126Atrioventricular block (HP:0001678)1.92653404
127Poikilocytosis (HP:0004447)1.92433112
128Rhabdomyolysis (HP:0003201)1.91292158
129Nephrolithiasis (HP:0000787)1.90923787
130Polycythemia (HP:0001901)1.90022323
131Delayed epiphyseal ossification (HP:0002663)1.88548559
132Lipid accumulation in hepatocytes (HP:0006561)1.87916366
133Recurrent cutaneous fungal infections (HP:0011370)1.85033358
134Chronic mucocutaneous candidiasis (HP:0002728)1.85033358
135Pigmentary retinal degeneration (HP:0001146)1.84001733
136Hyperphosphaturia (HP:0003109)1.83333742
137Abnormality of the gallbladder (HP:0005264)1.82865906
138Increased muscle lipid content (HP:0009058)1.82843643
139Abnormality of the Achilles tendon (HP:0005109)1.82482570
140Reticulocytosis (HP:0001923)1.82231209
141J-shaped sella turcica (HP:0002680)1.81439630
142Hypoglycemic seizures (HP:0002173)1.80716458
143Epistaxis (HP:0000421)1.80182209
144Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.79921312
145Increased hepatocellular lipid droplets (HP:0006565)1.79797303
146Abnormality of the vitreous humor (HP:0004327)1.79413518
147Abnormality of iron homeostasis (HP:0011031)1.79080945
148Steatorrhea (HP:0002570)1.76065746
149Patellar aplasia (HP:0006443)1.76041478
150Agammaglobulinemia (HP:0004432)1.75193622
151Cheilitis (HP:0100825)1.74572271
152Mitral stenosis (HP:0001718)1.73765792
153Increased serum ferritin (HP:0003281)1.72660750
154Dyschromatopsia (HP:0007641)1.72456181
155Axonal loss (HP:0003447)1.72235733
156Hypophosphatemia (HP:0002148)1.71603919
157Status epilepticus (HP:0002133)1.71304378
158Rickets (HP:0002748)1.71204129
159Abnormality of transition element cation homeostasis (HP:0011030)1.68608052
160Orchitis (HP:0100796)1.68231667
161Methylmalonic aciduria (HP:0012120)1.67370571

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.66829749
2TESK24.42566966
3TRIB33.99893101
4SIK13.62640246
5ERN13.60653660
6ACVR1B3.44612943
7MAPK153.27815662
8MST1R2.90719225
9FGFR42.75464153
10MAP4K12.72815413
11CAMK1D2.24859139
12PDK32.17393199
13PDK42.17393199
14LMTK22.11523593
15RIPK11.91443346
16PKN21.89136990
17DAPK21.68309718
18TNK21.64211037
19TLK11.60588772
20WNK41.56749217
21FRK1.53122525
22BMPR1B1.51493944
23RIPK41.47932343
24MAP2K41.45407493
25CAMK1G1.40166634
26BLK1.34188742
27PRKD21.32176690
28PINK11.32066148
29MAPK111.30521256
30KSR21.26904924
31PRKAA21.26242047
32NEK11.20543803
33TAOK31.19786441
34PDK21.16509438
35MAP4K21.15935584
36DYRK1B1.15770517
37PTK61.13586121
38INSRR1.12754049
39GRK61.12728577
40NEK91.11662935
41ARAF1.10798928
42ZAP701.10674474
43MAP2K11.09237299
44GRK11.07446521
45MYLK1.01432666
46SYK1.00520135
47MAPKAPK30.99298196
48PDPK10.99142958
49MAP3K70.97563275
50TXK0.97432744
51MARK20.95554946
52IKBKB0.93679600
53GRK50.92973432
54JAK20.92605808
55FER0.92201798
56MAP3K20.92033293
57ZAK0.90544010
58PDGFRA0.90534644
59MAP3K90.89787658
60MAP2K20.88694708
61PIM20.88686284
62PRPF4B0.88443924
63NME10.88203751
64MAP3K30.87585771
65CAMKK20.85767834
66JAK10.84632681
67MAP3K130.83983112
68TYK20.83208228
69RET0.82872568
70CDC42BPA0.82427373
71MET0.82246161
72STK38L0.81891599
73PRKAA10.81057644
74SGK30.80720341
75BTK0.79676085
76TTN0.79562182
77ADRBK20.79484204
78ADRBK10.78723612
79SMG10.77706629
80TAOK10.76410953
81STK380.76376150
82PDK10.75541954
83FGFR30.75095297
84CSF1R0.74125990
85MAP2K30.73251096
86RPS6KA60.72955852
87WNK30.72688457
88MAP3K110.72511590
89LATS10.71677632
90ABL20.71291136
91LRRK20.70936267
92PIK3CG0.70603941
93PRKACG0.69376826
94PTK20.69355287
95MUSK0.69333889
96TGFBR20.69328649
97IKBKE0.68551511
98MAPK120.67648251
99ITK0.67234121
100LATS20.67106838
101SIK30.66450512
102FGFR20.66269433
103PHKG10.65079020
104PHKG20.65079020
105FES0.64482970
106KDR0.64285991
107ERBB40.64103472
108WNK10.63020248
109PRKCZ0.62913288
110ICK0.61880832
111PRKCH0.61675533
112TIE10.59877954
113LYN0.59084399
114SGK2230.58964711
115SGK4940.58964711
116CSK0.58824151
117EPHB10.58349655
118EPHA40.57712913
119PRKCQ0.57670176
120HIPK20.57523803
121BMX0.57135387
122NTRK10.56337756
123KIT0.55893251
124IRAK40.54286604
125CAMKK10.54108951
126LCK0.54061351
127MAP3K10.54018810
128EPHB20.53999664
129MAP2K60.53527120
130EPHA20.52302104
131OXSR10.52235422
132PTK2B0.52235157
133JAK30.52206255
134RPS6KC10.52094230
135RPS6KL10.52094230
136SIK20.50585065
137FLT30.50348471
138PRKG20.49364695
139CDK60.48775735
140MAP3K100.48472548
141SGK20.47623946
142CAMK10.47545443
143TGFBR10.47496507
144CASK0.45349240
145AKT30.44950358
146GSK3A0.44690259
147TBK10.43404735
148CAMK2G0.42499952
149MAP3K140.42176642
150RPS6KA20.41052026
151CDK40.39528816
152DAPK10.39440660
153PRKD10.39075102
154CAMK40.37904650
155IRAK30.36762479
156HCK0.35526958
157MAPK40.34354085
158MTOR0.34144001

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.33359025
2Nitrogen metabolism_Homo sapiens_hsa009103.07457851
3Fatty acid degradation_Homo sapiens_hsa000712.91273450
4Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.89528650
5Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.83508968
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.81067660
7Propanoate metabolism_Homo sapiens_hsa006402.78974931
8Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.75627174
9Arginine biosynthesis_Homo sapiens_hsa002202.62130227
10PPAR signaling pathway_Homo sapiens_hsa033202.53903710
11Tryptophan metabolism_Homo sapiens_hsa003802.41463550
122-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.36509504
13Fatty acid metabolism_Homo sapiens_hsa012122.36012246
14Butanoate metabolism_Homo sapiens_hsa006502.31988228
15Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.25943788
16Peroxisome_Homo sapiens_hsa041462.13974976
17Pyruvate metabolism_Homo sapiens_hsa006202.01163947
18Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.98854047
19Pentose and glucuronate interconversions_Homo sapiens_hsa000401.98418163
20Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.97234316
21Other glycan degradation_Homo sapiens_hsa005111.90420878
22beta-Alanine metabolism_Homo sapiens_hsa004101.89142831
23Glycosaminoglycan degradation_Homo sapiens_hsa005311.88434158
24Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.83000213
25Complement and coagulation cascades_Homo sapiens_hsa046101.77726791
26Caffeine metabolism_Homo sapiens_hsa002321.65248251
27Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.64741049
28Carbon metabolism_Homo sapiens_hsa012001.58766531
29Bile secretion_Homo sapiens_hsa049761.55547608
30Cyanoamino acid metabolism_Homo sapiens_hsa004601.53531340
31Fat digestion and absorption_Homo sapiens_hsa049751.52562889
32Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.49382429
33Phenylalanine metabolism_Homo sapiens_hsa003601.47839977
34Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.46509291
35Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.45288691
36Histidine metabolism_Homo sapiens_hsa003401.44553428
37Chemical carcinogenesis_Homo sapiens_hsa052041.42428258
38Fatty acid biosynthesis_Homo sapiens_hsa000611.37601731
39Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.37452872
40Starch and sucrose metabolism_Homo sapiens_hsa005001.34832490
41Glycerolipid metabolism_Homo sapiens_hsa005611.34139897
42Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.29926935
43Sulfur metabolism_Homo sapiens_hsa009201.29394168
44Arachidonic acid metabolism_Homo sapiens_hsa005901.28606243
45Primary immunodeficiency_Homo sapiens_hsa053401.23525946
46Drug metabolism - other enzymes_Homo sapiens_hsa009831.21828738
47Fatty acid elongation_Homo sapiens_hsa000621.21818152
48Tyrosine metabolism_Homo sapiens_hsa003501.21295541
49Biosynthesis of amino acids_Homo sapiens_hsa012301.18966373
50Retinol metabolism_Homo sapiens_hsa008301.17805192
51Steroid hormone biosynthesis_Homo sapiens_hsa001401.13774054
52Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.08246561
53Staphylococcus aureus infection_Homo sapiens_hsa051501.06480867
54Folate biosynthesis_Homo sapiens_hsa007901.05207040
55Selenocompound metabolism_Homo sapiens_hsa004501.02802046
56Vitamin digestion and absorption_Homo sapiens_hsa049771.02667337
57ABC transporters_Homo sapiens_hsa020100.98674118
58Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.98199843
59Intestinal immune network for IgA production_Homo sapiens_hsa046720.97908940
60Cysteine and methionine metabolism_Homo sapiens_hsa002700.92281230
61Vitamin B6 metabolism_Homo sapiens_hsa007500.88793475
62Sulfur relay system_Homo sapiens_hsa041220.85304608
63Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.85140955
64Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.83249145
65Arginine and proline metabolism_Homo sapiens_hsa003300.81792637
66Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.80678641
67Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.75483455
68Glutathione metabolism_Homo sapiens_hsa004800.75231426
69Adipocytokine signaling pathway_Homo sapiens_hsa049200.72072974
70Lysine degradation_Homo sapiens_hsa003100.71908323
71Pentose phosphate pathway_Homo sapiens_hsa000300.71011259
72Fructose and mannose metabolism_Homo sapiens_hsa000510.66481654
73Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.64924852
74Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.61643869
75Ovarian steroidogenesis_Homo sapiens_hsa049130.57512859
76Insulin resistance_Homo sapiens_hsa049310.53032397
77Galactose metabolism_Homo sapiens_hsa000520.49331288
78Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.49186723
79Maturity onset diabetes of the young_Homo sapiens_hsa049500.48527720
80Allograft rejection_Homo sapiens_hsa053300.48465108
81Sphingolipid metabolism_Homo sapiens_hsa006000.47235567
82Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.45679854
83AMPK signaling pathway_Homo sapiens_hsa041520.45605370
84Metabolic pathways_Homo sapiens_hsa011000.43164193
85Autoimmune thyroid disease_Homo sapiens_hsa053200.42659800
86Glycerophospholipid metabolism_Homo sapiens_hsa005640.39534191
87Glucagon signaling pathway_Homo sapiens_hsa049220.38322404
88Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.33281504
89Pertussis_Homo sapiens_hsa051330.33104098
90Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.32637952
91Steroid biosynthesis_Homo sapiens_hsa001000.32031453
92Hematopoietic cell lineage_Homo sapiens_hsa046400.31330506
93Graft-versus-host disease_Homo sapiens_hsa053320.28319544
94Insulin signaling pathway_Homo sapiens_hsa049100.28154390
95Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.27192815
96Phototransduction_Homo sapiens_hsa047440.26988029
97Asthma_Homo sapiens_hsa053100.26793687
98Protein digestion and absorption_Homo sapiens_hsa049740.25868606
99Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.24620185
100Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.24595321
101Aldosterone synthesis and secretion_Homo sapiens_hsa049250.24528708
102Renin-angiotensin system_Homo sapiens_hsa046140.24347528
103Type I diabetes mellitus_Homo sapiens_hsa049400.23015461
104Mineral absorption_Homo sapiens_hsa049780.22439866
105Carbohydrate digestion and absorption_Homo sapiens_hsa049730.21698019
106VEGF signaling pathway_Homo sapiens_hsa043700.21419814
107Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.20823562
108alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.19332927
109Circadian rhythm_Homo sapiens_hsa047100.16697690
110Thyroid hormone synthesis_Homo sapiens_hsa049180.14028327
111NF-kappa B signaling pathway_Homo sapiens_hsa040640.13209033
112Prion diseases_Homo sapiens_hsa050200.10676737
113Central carbon metabolism in cancer_Homo sapiens_hsa052300.10394837
114Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.10336585
115Longevity regulating pathway - mammal_Homo sapiens_hsa042110.06087574
116Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962-0.0958629
117Collecting duct acid secretion_Homo sapiens_hsa04966-0.0952347
118Renin secretion_Homo sapiens_hsa04924-0.0944941
119Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.0886188
120Parkinsons disease_Homo sapiens_hsa05012-0.0875853
121Lysosome_Homo sapiens_hsa04142-0.0751718
122Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.0728775
123Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0722933
124Oxidative phosphorylation_Homo sapiens_hsa00190-0.0662568
125Bladder cancer_Homo sapiens_hsa05219-0.0625618
126Linoleic acid metabolism_Homo sapiens_hsa00591-0.0261133
127Type II diabetes mellitus_Homo sapiens_hsa04930-0.0194834

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