Rank | Gene Set | Z-score |
---|---|---|
1 | L-phenylalanine catabolic process (GO:0006559) | 5.72581564 |
2 | erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222) | 5.72581564 |
3 | L-phenylalanine metabolic process (GO:0006558) | 5.71768549 |
4 | erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221) | 5.71768549 |
5 | triglyceride-rich lipoprotein particle remodeling (GO:0034370) | 5.34868359 |
6 | lysine catabolic process (GO:0006554) | 5.05569920 |
7 | lysine metabolic process (GO:0006553) | 5.05569920 |
8 | cysteine metabolic process (GO:0006534) | 5.04858274 |
9 | alpha-linolenic acid metabolic process (GO:0036109) | 5.01062908 |
10 | aromatic amino acid family catabolic process (GO:0009074) | 5.00844574 |
11 | fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540) | 4.91755302 |
12 | sulfur amino acid catabolic process (GO:0000098) | 4.86937312 |
13 | glyoxylate metabolic process (GO:0046487) | 4.79661822 |
14 | regulation of triglyceride catabolic process (GO:0010896) | 4.60692389 |
15 | valine metabolic process (GO:0006573) | 4.53331077 |
16 | amino-acid betaine metabolic process (GO:0006577) | 4.43391725 |
17 | indole-containing compound catabolic process (GO:0042436) | 4.40498358 |
18 | indolalkylamine catabolic process (GO:0046218) | 4.40498358 |
19 | tryptophan catabolic process (GO:0006569) | 4.40498358 |
20 | kynurenine metabolic process (GO:0070189) | 4.34878806 |
21 | fatty acid beta-oxidation (GO:0006635) | 4.32674356 |
22 | bile acid biosynthetic process (GO:0006699) | 4.32330485 |
23 | urea metabolic process (GO:0019627) | 4.30021280 |
24 | urea cycle (GO:0000050) | 4.30021280 |
25 | serine family amino acid catabolic process (GO:0009071) | 4.28988421 |
26 | acetyl-CoA metabolic process (GO:0006084) | 4.20094334 |
27 | drug catabolic process (GO:0042737) | 4.15188531 |
28 | complement activation, alternative pathway (GO:0006957) | 4.14536823 |
29 | homocysteine metabolic process (GO:0050667) | 4.13212257 |
30 | tryptophan metabolic process (GO:0006568) | 4.11963299 |
31 | regulation of antigen processing and presentation of peptide antigen (GO:0002583) | 4.11272258 |
32 | short-chain fatty acid metabolic process (GO:0046459) | 4.10295075 |
33 | antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885) | 4.08978721 |
34 | fatty acid oxidation (GO:0019395) | 4.08358501 |
35 | antigen processing and presentation of endogenous peptide antigen (GO:0002483) | 4.05430660 |
36 | acylglycerol homeostasis (GO:0055090) | 4.03054550 |
37 | triglyceride homeostasis (GO:0070328) | 4.03054550 |
38 | high-density lipoprotein particle remodeling (GO:0034375) | 4.02407684 |
39 | lipid oxidation (GO:0034440) | 4.02253352 |
40 | plasma lipoprotein particle clearance (GO:0034381) | 4.02031308 |
41 | 2-oxoglutarate metabolic process (GO:0006103) | 3.99947104 |
42 | nitrogen cycle metabolic process (GO:0071941) | 3.99623551 |
43 | positive regulation of fatty acid beta-oxidation (GO:0032000) | 3.97157736 |
44 | fatty acid catabolic process (GO:0009062) | 3.96312978 |
45 | antigen processing and presentation of endogenous antigen (GO:0019883) | 3.87799811 |
46 | positive regulation of lipid catabolic process (GO:0050996) | 3.86315331 |
47 | alpha-amino acid catabolic process (GO:1901606) | 3.86238267 |
48 | drug transmembrane transport (GO:0006855) | 3.81061763 |
49 | biotin metabolic process (GO:0006768) | 3.81057702 |
50 | carnitine metabolic process (GO:0009437) | 3.81013910 |
51 | cellular ketone body metabolic process (GO:0046950) | 3.80767279 |
52 | arginine metabolic process (GO:0006525) | 3.77883394 |
53 | regulation of cholesterol homeostasis (GO:2000188) | 3.76868004 |
54 | monocarboxylic acid catabolic process (GO:0072329) | 3.75842315 |
55 | low-density lipoprotein particle clearance (GO:0034383) | 3.75097070 |
56 | regulation of protein activation cascade (GO:2000257) | 3.75083474 |
57 | cellular amino acid catabolic process (GO:0009063) | 3.74406264 |
58 | bile acid metabolic process (GO:0008206) | 3.74170219 |
59 | positive regulation of fatty acid oxidation (GO:0046321) | 3.73784826 |
60 | exogenous drug catabolic process (GO:0042738) | 3.73167623 |
61 | reverse cholesterol transport (GO:0043691) | 3.72979575 |
62 | peptidyl-glutamic acid carboxylation (GO:0017187) | 3.72502752 |
63 | protein carboxylation (GO:0018214) | 3.72502752 |
64 | GDP-mannose metabolic process (GO:0019673) | 3.70766405 |
65 | fatty acid transmembrane transport (GO:1902001) | 3.70398674 |
66 | cellular modified amino acid catabolic process (GO:0042219) | 3.70176089 |
67 | regulation of cholesterol esterification (GO:0010872) | 3.69545683 |
68 | omega-hydroxylase P450 pathway (GO:0097267) | 3.68319628 |
69 | aromatic amino acid family metabolic process (GO:0009072) | 3.67826404 |
70 | ethanol metabolic process (GO:0006067) | 3.67685872 |
71 | branched-chain amino acid metabolic process (GO:0009081) | 3.67639600 |
72 | ethanol oxidation (GO:0006069) | 3.66233260 |
73 | regulation of sequestering of triglyceride (GO:0010889) | 3.65209343 |
74 | phospholipid efflux (GO:0033700) | 3.64593150 |
75 | urate metabolic process (GO:0046415) | 3.64236841 |
76 | aspartate family amino acid catabolic process (GO:0009068) | 3.62961204 |
77 | protein-lipid complex remodeling (GO:0034368) | 3.61813130 |
78 | macromolecular complex remodeling (GO:0034367) | 3.61813130 |
79 | plasma lipoprotein particle remodeling (GO:0034369) | 3.61813130 |
80 | branched-chain amino acid catabolic process (GO:0009083) | 3.61253705 |
81 | triglyceride catabolic process (GO:0019433) | 3.60175592 |
82 | glutamate metabolic process (GO:0006536) | 3.59759835 |
83 | regulation of complement activation (GO:0030449) | 3.59320213 |
84 | negative regulation of fibrinolysis (GO:0051918) | 3.59281040 |
85 | acylglycerol catabolic process (GO:0046464) | 3.57543227 |
86 | neutral lipid catabolic process (GO:0046461) | 3.57543227 |
87 | organic acid catabolic process (GO:0016054) | 3.56033779 |
88 | carboxylic acid catabolic process (GO:0046395) | 3.56033779 |
89 | coenzyme catabolic process (GO:0009109) | 3.52620731 |
90 | very-low-density lipoprotein particle assembly (GO:0034379) | 3.50394421 |
91 | tyrosine metabolic process (GO:0006570) | 3.47727394 |
92 | negative regulation of cholesterol transport (GO:0032375) | 3.47657489 |
93 | negative regulation of sterol transport (GO:0032372) | 3.47657489 |
94 | intestinal cholesterol absorption (GO:0030299) | 3.47415419 |
95 | regulation of fatty acid beta-oxidation (GO:0031998) | 3.47003600 |
96 | blood coagulation, intrinsic pathway (GO:0007597) | 3.46960398 |
97 | mannose metabolic process (GO:0006013) | 3.45276815 |
98 | arginine catabolic process (GO:0006527) | 3.44575384 |
99 | alkaloid metabolic process (GO:0009820) | 3.44300987 |
100 | tricarboxylic acid metabolic process (GO:0072350) | 3.41546275 |
101 | positive regulation of triglyceride lipase activity (GO:0061365) | 3.39358056 |
102 | positive regulation of lipoprotein lipase activity (GO:0051006) | 3.39358056 |
103 | oxaloacetate metabolic process (GO:0006107) | 3.38946533 |
104 | serine family amino acid metabolic process (GO:0009069) | 3.38939496 |
105 | carnitine shuttle (GO:0006853) | 3.37222935 |
106 | NADH metabolic process (GO:0006734) | 3.36730361 |
107 | regulation of cytokine production involved in inflammatory response (GO:1900015) | 3.36663416 |
108 | drug metabolic process (GO:0017144) | 3.35752706 |
109 | regulation of fibrinolysis (GO:0051917) | 3.35333864 |
110 | positive regulation of triglyceride metabolic process (GO:0090208) | 3.34097694 |
111 | dicarboxylic acid biosynthetic process (GO:0043650) | 3.33601122 |
112 | flavonoid metabolic process (GO:0009812) | 3.32193037 |
113 | epoxygenase P450 pathway (GO:0019373) | 3.28639387 |
114 | fat-soluble vitamin biosynthetic process (GO:0042362) | 3.26514035 |
115 | positive regulation of fatty acid metabolic process (GO:0045923) | 3.25892708 |
116 | ketone body metabolic process (GO:1902224) | 3.25380335 |
117 | plasma lipoprotein particle organization (GO:0071827) | 3.24948763 |
118 | antigen processing and presentation via MHC class Ib (GO:0002475) | 3.24761135 |
119 | bile acid and bile salt transport (GO:0015721) | 3.24275098 |
120 | diacylglycerol metabolic process (GO:0046339) | 3.23692902 |
121 | transepithelial transport (GO:0070633) | 3.20599712 |
122 | proline metabolic process (GO:0006560) | 3.19131879 |
123 | protein activation cascade (GO:0072376) | 3.18067736 |
124 | complement activation, classical pathway (GO:0006958) | 3.17060801 |
125 | cholesterol efflux (GO:0033344) | 3.15134919 |
126 | regulation of guanylate cyclase activity (GO:0031282) | 3.11131839 |
127 | hormone catabolic process (GO:0042447) | 3.08647456 |
128 | regulation of plasminogen activation (GO:0010755) | 3.08496336 |
129 | S-adenosylmethionine metabolic process (GO:0046500) | 3.07975484 |
130 | positive regulation of fatty acid biosynthetic process (GO:0045723) | 3.06192249 |
131 | phenylpropanoid metabolic process (GO:0009698) | 3.02682782 |
132 | peptidyl-glutamic acid modification (GO:0018200) | 3.02406474 |
133 | complement activation (GO:0006956) | 3.02197811 |
134 | protein-lipid complex subunit organization (GO:0071825) | 3.00935552 |
135 | positive regulation of antigen processing and presentation (GO:0002579) | 2.98625419 |
136 | regulation of triglyceride metabolic process (GO:0090207) | 2.97796711 |
137 | regulation of cholesterol metabolic process (GO:0090181) | 2.91055421 |
138 | plasma lipoprotein particle assembly (GO:0034377) | 2.90122724 |
139 | drug transport (GO:0015893) | 2.87794970 |
140 | oxidative demethylation (GO:0070989) | 2.87271116 |
141 | acute-phase response (GO:0006953) | 2.86590389 |
142 | negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665) | 2.86045138 |
143 | response to misfolded protein (GO:0051788) | 2.84560195 |
144 | regulation of humoral immune response (GO:0002920) | 2.83954930 |
145 | fibrinolysis (GO:0042730) | 2.83662772 |
146 | negative regulation of amyloid precursor protein catabolic process (GO:1902992) | 2.78587684 |
147 | cellular glucuronidation (GO:0052695) | 2.77569260 |
148 | regulation of lipoprotein particle clearance (GO:0010984) | 2.76962217 |
149 | uronic acid metabolic process (GO:0006063) | 2.75360281 |
150 | glucuronate metabolic process (GO:0019585) | 2.75360281 |
151 | intestinal absorption (GO:0050892) | 2.75181351 |
152 | imidazole-containing compound metabolic process (GO:0052803) | 2.72517980 |
153 | regulation of hydrogen peroxide metabolic process (GO:0010310) | 2.68544406 |
154 | positive regulation of guanylate cyclase activity (GO:0031284) | 2.64665067 |
Rank | Gene Set | Z-score |
---|---|---|
1 | ESR1_17901129_ChIP-ChIP_LIVER_Mouse | 8.87806777 |
2 | * PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 7.78268614 |
3 | * RXR_22158963_ChIP-Seq_LIVER_Mouse | 6.50077556 |
4 | * PPARA_22158963_ChIP-Seq_LIVER_Mouse | 5.73961658 |
5 | LXR_22158963_ChIP-Seq_LIVER_Mouse | 5.07279256 |
6 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 4.17644518 |
7 | FOXO1_23066095_ChIP-Seq_LIVER_Mouse | 4.16571051 |
8 | * TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse | 3.56499327 |
9 | NR1I2_20693526_ChIP-Seq_LIVER_Mouse | 3.41012628 |
10 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 3.19290433 |
11 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 3.06973803 |
12 | VDR_21846776_ChIP-Seq_THP-1_Human | 3.00923799 |
13 | CLOCK_20551151_ChIP-Seq_293T_Human | 2.58862174 |
14 | CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 2.57408023 |
15 | TP63_17297297_ChIP-ChIP_HaCaT_Human | 2.23620825 |
16 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 2.21065342 |
17 | E2F1_20622854_ChIP-Seq_HELA_Human | 2.20860470 |
18 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 2.08495615 |
19 | ZNF263_19887448_ChIP-Seq_K562_Human | 2.05076246 |
20 | PHF8_20622854_ChIP-Seq_HELA_Human | 2.00996221 |
21 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.92976500 |
22 | ELF1_20517297_ChIP-Seq_JURKAT_Human | 1.91951402 |
23 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 1.83009648 |
24 | TCF7L2_21901280_ChIP-Seq_H4IIE_Rat | 1.82036249 |
25 | * E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human | 1.80447674 |
26 | EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.79170347 |
27 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 1.77898911 |
28 | MAF_26560356_Chip-Seq_TH2_Human | 1.76150933 |
29 | * RARB_24833708_ChIP-Seq_LIVER_Mouse | 1.74381014 |
30 | CTCF_27219007_Chip-Seq_ERYTHROID_Human | 1.67821191 |
31 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 1.64924923 |
32 | GATA1_22025678_ChIP-Seq_K562_Human | 1.62376199 |
33 | * SA1_27219007_Chip-Seq_Bcells_Human | 1.61705699 |
34 | MAF_26560356_Chip-Seq_TH1_Human | 1.60689531 |
35 | * CTCF_20526341_ChIP-Seq_ESCs_Human | 1.60349051 |
36 | YY1_22570637_ChIP-Seq_MALME-3M_Human | 1.60121783 |
37 | SA1_27219007_Chip-Seq_ERYTHROID_Human | 1.59514667 |
38 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 1.57629995 |
39 | ESR2_21235772_ChIP-Seq_MCF-7_Human | 1.56004418 |
40 | KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 1.53586220 |
41 | VDR_24763502_ChIP-Seq_THP-1_Human | 1.52786602 |
42 | MYC_22102868_ChIP-Seq_BL_Human | 1.52604235 |
43 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 1.50404564 |
44 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.48959467 |
45 | ERA_21632823_ChIP-Seq_H3396_Human | 1.48549711 |
46 | UTX_26944678_Chip-Seq_JUKART_Human | 1.47593817 |
47 | FOXA2_19822575_ChIP-Seq_HepG2_Human | 1.45451155 |
48 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 1.43003407 |
49 | GATA2_20887958_ChIP-Seq_HPC-7_Mouse | 1.42753506 |
50 | KDM2B_26808549_Chip-Seq_DND41_Human | 1.42469262 |
51 | RBPJ_21746931_ChIP-Seq_IB4-LCL_Human | 1.41212393 |
52 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 1.40938060 |
53 | SREBP2_21459322_ChIP-Seq_LIVER_Mouse | 1.40205225 |
54 | P300_27268052_Chip-Seq_Bcells_Human | 1.39179541 |
55 | RAC3_21632823_ChIP-Seq_H3396_Human | 1.34522706 |
56 | * CTCF_21964334_Chip-Seq_Bcells_Human | 1.33895678 |
57 | LXR_22292898_ChIP-Seq_THP-1_Human | 1.33193083 |
58 | * FOXP1_21924763_ChIP-Seq_HESCs_Human | 1.33176641 |
59 | MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human | 1.32647739 |
60 | * CTCF_26484167_Chip-Seq_Bcells_Mouse | 1.30944918 |
61 | STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse | 1.30026479 |
62 | * CTCF_21964334_ChIP-Seq_BJAB-B_Human | 1.26409938 |
63 | HNF4A_19822575_ChIP-Seq_HepG2_Human | 1.24418851 |
64 | TCF7_22412390_ChIP-Seq_EML_Mouse | 1.24091446 |
65 | SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.23693147 |
66 | TRIM28_21343339_ChIP-Seq_HEK293_Human | 1.23300105 |
67 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.22945694 |
68 | PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse | 1.22007437 |
69 | DROSHA_22980978_ChIP-Seq_HELA_Human | 1.21813223 |
70 | SOX2_27498859_Chip-Seq_STOMACH_Mouse | 1.19571900 |
71 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.19274585 |
72 | SPI1_20517297_ChIP-Seq_HL60_Human | 1.19094167 |
73 | PU.1_20513432_ChIP-Seq_Bcells_Mouse | 1.19067626 |
74 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 1.18384158 |
75 | CREB1_26743006_Chip-Seq_LNCaP-abl_Human | 1.17977400 |
76 | OCT4_19829295_ChIP-Seq_ESCs_Human | 1.17926172 |
77 | ETS1_21867929_ChIP-Seq_TH2_Mouse | 1.16953494 |
78 | MEIS1_20887958_ChIP-Seq_HPC-7_Mouse | 1.16893246 |
79 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.15216670 |
80 | NR0B1_18358816_ChIP-ChIP_MESCs_Mouse | 1.13442764 |
81 | JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse | 1.11359695 |
82 | ESR1_21235772_ChIP-Seq_MCF-7_Human | 1.11341671 |
83 | PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse | 1.09527066 |
84 | ZNF652_21678463_ChIP-ChIP_ZR75-1_Human | 1.08309711 |
85 | MYC_19829295_ChIP-Seq_ESCs_Human | 1.07714073 |
86 | NANOG_20526341_ChIP-Seq_ESCs_Human | 1.07112836 |
87 | TP53_22127205_ChIP-Seq_IMR90_Human | 1.06696821 |
88 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 1.06322110 |
89 | TAF2_19829295_ChIP-Seq_ESCs_Human | 1.06203346 |
90 | RUNX1_22412390_ChIP-Seq_EML_Mouse | 1.05906729 |
91 | OCT4_20526341_ChIP-Seq_ESCs_Human | 1.05070880 |
92 | CDX2_20551321_ChIP-Seq_CACO-2_Human | 1.04936975 |
93 | RACK7_27058665_Chip-Seq_MCF-7_Human | 1.04378055 |
94 | TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 1.03767424 |
95 | SOX2_21211035_ChIP-Seq_LN229_Human | 1.03126984 |
96 | BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human | 1.01586317 |
97 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 1.00311124 |
98 | GATA4_25053715_ChIP-Seq_YYC3_Human | 0.98710525 |
99 | PPAR_26484153_Chip-Seq_NCI-H1993_Human | 0.97654877 |
100 | FOXO3_23340844_ChIP-Seq_DLD1_Human | 0.96355858 |
101 | TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 0.94350575 |
102 | CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse | 0.93966768 |
103 | * SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 0.93731736 |
104 | TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 0.92766103 |
105 | ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse | 0.91011751 |
106 | GATA1_19941826_ChIP-Seq_K562_Human | 0.90354425 |
107 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 0.88974801 |
108 | SREBP1_19666523_ChIP-Seq_LIVER_Mouse | 0.88846077 |
109 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 0.84259681 |
110 | RXRA_24833708_ChIP-Seq_LIVER_Mouse | 0.83637403 |
111 | TBX20_22328084_ChIP-Seq_HEART_Mouse | 0.82100426 |
112 | TBX20_22080862_ChIP-Seq_HEART_Mouse | 0.82100426 |
113 | ESR1_20079471_ChIP-ChIP_T-47D_Human | 0.81572917 |
114 | DNAJC2_21179169_ChIP-ChIP_NT2_Human | 0.81510103 |
115 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 0.81208034 |
116 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 0.80720501 |
117 | GATA2_19941826_ChIP-Seq_K562_Human | 0.79858727 |
118 | SMAD2/3_21741376_ChIP-Seq_ESCs_Human | 0.79603097 |
119 | ESR1_22446102_ChIP-Seq_UTERUS_Mouse | 0.77890173 |
120 | ATF3_27146783_Chip-Seq_COLON_Human | 0.77368625 |
121 | SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 0.77361612 |
122 | * RAD21_21589869_ChIP-Seq_MESCs_Mouse | 0.76797627 |
123 | SOX2_20726797_ChIP-Seq_SW620_Human | 0.76633258 |
124 | KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human | 0.74854978 |
125 | GATA1_19941827_ChIP-Seq_MEL_Mouse | 0.74574718 |
126 | EGR1_19032775_ChIP-ChIP_M12_Human | 0.73691423 |
127 | PPARG_20887899_ChIP-Seq_3T3-L1_Mouse | 0.73674109 |
128 | * TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 0.73164687 |
129 | AR_21915096_ChIP-Seq_LNCaP-1F5_Human | 0.72415518 |
130 | BMI1_19503595_ChIP-Seq_MEFsC_Mouse | 0.72378064 |
131 | PPARD_23208498_ChIP-Seq_MDA-MB-231_Human | 0.71652767 |
132 | CREB1_26743006_Chip-Seq_LNCaP_Human | 0.70164124 |
133 | P63_26484246_Chip-Seq_KERATINOCYTES_Human | 0.69463015 |
134 | PPARG_20176806_ChIP-Seq_3T3-L1_Mouse | 0.69003140 |
135 | P68_20966046_ChIP-Seq_HELA_Human | 0.67062055 |
136 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 0.65993110 |
137 | TET1_21451524_ChIP-Seq_MESCs_Mouse | 0.65867083 |
138 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 0.65679853 |
139 | STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse | 0.65629027 |
140 | ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human | 0.65191971 |
141 | TP63_22573176_ChIP-Seq_HFKS_Human | 0.64532752 |
142 | GATA6_25053715_ChIP-Seq_YYC3_Human | 0.64511043 |
143 | * CTCF_27219007_Chip-Seq_Bcells_Human | 0.63121873 |
144 | BCOR_27268052_Chip-Seq_Bcells_Human | 0.63042999 |
145 | NFE2L2_20460467_ChIP-Seq_MEFs_Mouse | 0.62229398 |
146 | NRF2_20460467_ChIP-Seq_MEFs_Mouse | 0.62229398 |
147 | GATA3_20176728_ChIP-ChIP_TSCs_Mouse | 0.62087232 |
148 | P300_27058665_Chip-Seq_ZR-75-30cells_Human | 0.61707800 |
149 | BCL6_27268052_Chip-Seq_Bcells_Human | 0.61595002 |
150 | EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human | 0.60893336 |
151 | PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse | 0.60259719 |
152 | SOX9_24532713_ChIP-Seq_HFSC_Mouse | 0.59817224 |
153 | SMC4_20622854_ChIP-Seq_HELA_Human | 0.59630678 |
154 | RUNX1_27514584_Chip-Seq_MCF-7_Human | 0.59365386 |
155 | HIF1A_21447827_ChIP-Seq_MCF-7_Human | 0.58802630 |
156 | CEBPB_22108803_ChIP-Seq_LS180_Human | 0.58648124 |
157 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 0.58217473 |
158 | RARA_24833708_ChIP-Seq_LIVER_Mouse | 0.58162850 |
159 | BCAT_22108803_ChIP-Seq_LS180_Human | 0.57222949 |
160 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 0.57089681 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0005360_urolithiasis | 6.94305374 |
2 | MP0002139_abnormal_hepatobiliary_system | 6.82051753 |
3 | MP0005365_abnormal_bile_salt | 4.79863897 |
4 | MP0005085_abnormal_gallbladder_physiolo | 4.64437054 |
5 | MP0008875_abnormal_xenobiotic_pharmacok | 3.85799996 |
6 | MP0010329_abnormal_lipoprotein_level | 3.63560980 |
7 | MP0009840_abnormal_foam_cell | 3.07954440 |
8 | MP0003252_abnormal_bile_duct | 3.01690300 |
9 | MP0005332_abnormal_amino_acid | 2.99796673 |
10 | MP0003806_abnormal_nucleotide_metabolis | 2.98688477 |
11 | MP0005670_abnormal_white_adipose | 2.94154517 |
12 | MP0003191_abnormal_cellular_cholesterol | 2.58861482 |
13 | MP0001986_abnormal_taste_sensitivity | 2.38772806 |
14 | MP0004019_abnormal_vitamin_homeostasis | 2.37040946 |
15 | MP0001666_abnormal_nutrient_absorption | 2.31161792 |
16 | MP0003195_calcinosis | 2.29709280 |
17 | MP0002118_abnormal_lipid_homeostasis | 2.26582032 |
18 | MP0004130_abnormal_muscle_cell | 2.18923913 |
19 | MP0005666_abnormal_adipose_tissue | 2.09400586 |
20 | MP0005083_abnormal_biliary_tract | 2.05910004 |
21 | MP0000609_abnormal_liver_physiology | 1.99718688 |
22 | MP0003172_abnormal_lysosome_physiology | 1.96284714 |
23 | MP0002837_dystrophic_cardiac_calcinosis | 1.81944891 |
24 | MP0003705_abnormal_hypodermis_morpholog | 1.80432924 |
25 | MP0009643_abnormal_urine_homeostasis | 1.76825078 |
26 | MP0005319_abnormal_enzyme/_coenzyme | 1.75893654 |
27 | MP0005584_abnormal_enzyme/coenzyme_acti | 1.68526192 |
28 | MP0005167_abnormal_blood-brain_barrier | 1.66231291 |
29 | MP0003436_decreased_susceptibility_to | 1.65279783 |
30 | MP0001348_abnormal_lacrimal_gland | 1.58778778 |
31 | MP0002876_abnormal_thyroid_physiology | 1.57900590 |
32 | MP0002138_abnormal_hepatobiliary_system | 1.56951362 |
33 | MP0004185_abnormal_adipocyte_glucose | 1.56869534 |
34 | MP0002971_abnormal_brown_adipose | 1.55028482 |
35 | MP0000685_abnormal_immune_system | 1.51729025 |
36 | MP0001764_abnormal_homeostasis | 1.44282847 |
37 | MP0005375_adipose_tissue_phenotype | 1.41927911 |
38 | MP0003186_abnormal_redox_activity | 1.41217063 |
39 | MP0002254_reproductive_system_inflammat | 1.39829374 |
40 | MP0003879_abnormal_hair_cell | 1.38681979 |
41 | MP0003656_abnormal_erythrocyte_physiolo | 1.38035329 |
42 | MP0001790_abnormal_immune_system | 1.35222307 |
43 | MP0005387_immune_system_phenotype | 1.35222307 |
44 | MP0005535_abnormal_body_temperature | 1.33442352 |
45 | MP0002933_joint_inflammation | 1.30045611 |
46 | MP0006036_abnormal_mitochondrial_physio | 1.30009220 |
47 | MP0001873_stomach_inflammation | 1.26506466 |
48 | MP0005334_abnormal_fat_pad | 1.25974189 |
49 | MP0001756_abnormal_urination | 1.25526341 |
50 | MP0003183_abnormal_peptide_metabolism | 1.24463232 |
51 | MP0005025_abnormal_response_to | 1.17933492 |
52 | MP0005636_abnormal_mineral_homeostasis | 1.17777199 |
53 | MP0002796_impaired_skin_barrier | 1.17063470 |
54 | MP0004043_abnormal_pH_regulation | 1.15616273 |
55 | MP0009785_altered_susceptibility_to | 1.14272357 |
56 | MP0010234_abnormal_vibrissa_follicle | 1.14184364 |
57 | MP0005377_hearing/vestibular/ear_phenot | 1.12962480 |
58 | MP0003878_abnormal_ear_physiology | 1.12962480 |
59 | MP0009115_abnormal_fat_cell | 1.10890411 |
60 | MP0001849_ear_inflammation | 1.09309795 |
61 | MP0001502_abnormal_circadian_rhythm | 1.09082237 |
62 | MP0010155_abnormal_intestine_physiology | 1.08630495 |
63 | MP0002078_abnormal_glucose_homeostasis | 1.07934838 |
64 | MP0005671_abnormal_response_to | 1.05157430 |
65 | MP0000604_amyloidosis | 1.04537894 |
66 | MP0001800_abnormal_humoral_immune | 1.04506666 |
67 | MP0005275_abnormal_skin_tensile | 1.01463026 |
68 | MP0003329_amyloid_beta_deposits | 0.99602709 |
69 | MP0005448_abnormal_energy_balance | 0.98425431 |
70 | MP0002723_abnormal_immune_serum | 0.98356907 |
71 | MP0004147_increased_porphyrin_level | 0.97372256 |
72 | MP0005174_abnormal_tail_pigmentation | 0.95786724 |
73 | MP0000013_abnormal_adipose_tissue | 0.94966343 |
74 | MP0009333_abnormal_splenocyte_physiolog | 0.94016323 |
75 | MP0001835_abnormal_antigen_presentation | 0.94010696 |
76 | MP0002638_abnormal_pupillary_reflex | 0.93899336 |
77 | MP0008438_abnormal_cutaneous_collagen | 0.93552436 |
78 | MP0002136_abnormal_kidney_physiology | 0.92182974 |
79 | MP0000598_abnormal_liver_morphology | 0.91808713 |
80 | MP0003011_delayed_dark_adaptation | 0.91149321 |
81 | MP0005551_abnormal_eye_electrophysiolog | 0.90404088 |
82 | MP0009764_decreased_sensitivity_to | 0.90224435 |
83 | MP0005451_abnormal_body_composition | 0.89081285 |
84 | MP0002735_abnormal_chemical_nociception | 0.88622294 |
85 | MP0005171_absent_coat_pigmentation | 0.88173689 |
86 | MP0002970_abnormal_white_adipose | 0.86543469 |
87 | MP0003868_abnormal_feces_composition | 0.85348609 |
88 | MP0002419_abnormal_innate_immunity | 0.85152166 |
89 | MP0008961_abnormal_basal_metabolism | 0.85016647 |
90 | MP0005000_abnormal_immune_tolerance | 0.84675661 |
91 | MP0000003_abnormal_adipose_tissue | 0.84666563 |
92 | MP0003303_peritoneal_inflammation | 0.84487960 |
93 | MP0001661_extended_life_span | 0.84452088 |
94 | MP0009642_abnormal_blood_homeostasis | 0.83267227 |
95 | MP0001845_abnormal_inflammatory_respons | 0.82787520 |
96 | MP0002132_abnormal_respiratory_system | 0.82228819 |
97 | MP0003690_abnormal_glial_cell | 0.81262948 |
98 | MP0005647_abnormal_sex_gland | 0.81086431 |
99 | MP0001765_abnormal_ion_homeostasis | 0.80920777 |
100 | MP0001663_abnormal_digestive_system | 0.80540607 |
101 | MP0003646_muscle_fatigue | 0.79410078 |
102 | MP0005410_abnormal_fertilization | 0.77292262 |
103 | MP0005645_abnormal_hypothalamus_physiol | 0.76329003 |
104 | MP0002420_abnormal_adaptive_immunity | 0.74773541 |
105 | MP0001819_abnormal_immune_cell | 0.74582583 |
106 | MP0002452_abnormal_antigen_presenting | 0.74087940 |
107 | MP0000230_abnormal_systemic_arterial | 0.72760027 |
108 | MP0003136_yellow_coat_color | 0.71653743 |
109 | MP0005376_homeostasis/metabolism_phenot | 0.71293351 |
110 | MP0009763_increased_sensitivity_to | 0.69533825 |
111 | MP0002822_catalepsy | 0.69032351 |
112 | MP0005058_abnormal_lysosome_morphology | 0.68842962 |
113 | MP0005266_abnormal_metabolism | 0.68339072 |
114 | MP0005084_abnormal_gallbladder_morpholo | 0.67812723 |
115 | MP0000249_abnormal_blood_vessel | 0.66879532 |
116 | MP0003137_abnormal_impulse_conducting | 0.66472513 |
117 | MP0003953_abnormal_hormone_level | 0.64590311 |
118 | MP0008874_decreased_physiological_sensi | 0.64074303 |
119 | MP0008469_abnormal_protein_level | 0.64046127 |
120 | MP0008872_abnormal_physiological_respon | 0.63809570 |
121 | MP0002060_abnormal_skin_morphology | 0.62569175 |
122 | MP0002909_abnormal_adrenal_gland | 0.60800617 |
123 | MP0009780_abnormal_chondrocyte_physiolo | 0.59917818 |
124 | MP0002168_other_aberrant_phenotype | 0.59766370 |
125 | MP0003959_abnormal_lean_body | 0.59457657 |
126 | MP0006035_abnormal_mitochondrial_morpho | 0.58700868 |
127 | MP0008775_abnormal_heart_ventricle | 0.58197367 |
128 | MP0003075_altered_response_to | 0.58050154 |
129 | MP0009765_abnormal_xenobiotic_induced | 0.58014834 |
130 | MP0005330_cardiomyopathy | 0.57211308 |
131 | MP0006138_congestive_heart_failure | 0.56929969 |
132 | MP0001881_abnormal_mammary_gland | 0.56313147 |
133 | MP0003638_abnormal_response/metabolism_ | 0.52535817 |
134 | MP0004858_abnormal_nervous_system | 0.52342007 |
135 | MP0005452_abnormal_adipose_tissue | 0.52250797 |
136 | MP0005501_abnormal_skin_physiology | 0.51010570 |
137 | MP0009697_abnormal_copulation | 0.50798650 |
138 | MP0002269_muscular_atrophy | 0.50306049 |
139 | MP0003300_gastrointestinal_ulcer | 0.50093948 |
140 | MP0002332_abnormal_exercise_endurance | 0.48867134 |
141 | MP0001544_abnormal_cardiovascular_syste | 0.44950348 |
142 | MP0005385_cardiovascular_system_phenoty | 0.44950348 |
143 | MP0003724_increased_susceptibility_to | 0.42626647 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Xanthomatosis (HP:0000991) | 5.52139441 |
2 | Hyperglycinuria (HP:0003108) | 5.45428426 |
3 | Abnormality of aromatic amino acid family metabolism (HP:0004338) | 5.23833038 |
4 | Deep venous thrombosis (HP:0002625) | 4.80067464 |
5 | Abnormality of serine family amino acid metabolism (HP:0010894) | 4.78885220 |
6 | Abnormality of glycine metabolism (HP:0010895) | 4.78885220 |
7 | Abnormality of glutamine family amino acid metabolism (HP:0010902) | 4.77908309 |
8 | Intrahepatic cholestasis (HP:0001406) | 4.71853850 |
9 | Hyperlipoproteinemia (HP:0010980) | 4.64227513 |
10 | Abnormality of monocarboxylic acid metabolism (HP:0010996) | 4.46835632 |
11 | Ketosis (HP:0001946) | 4.44370121 |
12 | Hyperammonemia (HP:0001987) | 4.41631654 |
13 | Mesangial abnormality (HP:0001966) | 4.37430604 |
14 | Hyperglycinemia (HP:0002154) | 4.17732808 |
15 | Complement deficiency (HP:0004431) | 4.14174332 |
16 | Hypobetalipoproteinemia (HP:0003563) | 4.13725670 |
17 | Abnormality of fatty-acid metabolism (HP:0004359) | 3.86050888 |
18 | Ketoacidosis (HP:0001993) | 3.85233476 |
19 | Hypoglycemic coma (HP:0001325) | 3.78549249 |
20 | Prolonged partial thromboplastin time (HP:0003645) | 3.71509058 |
21 | Testicular atrophy (HP:0000029) | 3.67500696 |
22 | Hypolipoproteinemia (HP:0010981) | 3.66352107 |
23 | Hypoalphalipoproteinemia (HP:0003233) | 3.65437011 |
24 | Gout (HP:0001997) | 3.61526134 |
25 | Epidermoid cyst (HP:0200040) | 3.58970188 |
26 | Abnormality of the level of lipoprotein cholesterol (HP:0010979) | 3.56114060 |
27 | Hydroxyprolinuria (HP:0003080) | 3.44202157 |
28 | Abnormality of proline metabolism (HP:0010907) | 3.44202157 |
29 | Congenital stationary night blindness (HP:0007642) | 3.42726855 |
30 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 3.38911361 |
31 | Abnormality of purine metabolism (HP:0004352) | 3.38224843 |
32 | Abnormality of long-chain fatty-acid metabolism (HP:0010964) | 3.28754307 |
33 | Abnormality of sulfur amino acid metabolism (HP:0004339) | 3.27225039 |
34 | Abnormality of polysaccharide metabolism (HP:0011012) | 3.18820486 |
35 | Abnormality of glycosaminoglycan metabolism (HP:0004371) | 3.18820486 |
36 | Abnormality of mucopolysaccharide metabolism (HP:0011020) | 3.18820486 |
37 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 3.16457150 |
38 | Dicarboxylic aciduria (HP:0003215) | 3.16457150 |
39 | Birth length less than 3rd percentile (HP:0003561) | 3.16165570 |
40 | Abnormality of complement system (HP:0005339) | 2.96165730 |
41 | Hypercholesterolemia (HP:0003124) | 2.95246378 |
42 | Abnormality of nucleobase metabolism (HP:0010932) | 2.94570180 |
43 | Attenuation of retinal blood vessels (HP:0007843) | 2.90367811 |
44 | Metabolic acidosis (HP:0001942) | 2.89691542 |
45 | Mucopolysacchariduria (HP:0008155) | 2.89454552 |
46 | Urinary glycosaminoglycan excretion (HP:0003541) | 2.89454552 |
47 | Abnormality of the common coagulation pathway (HP:0010990) | 2.88728834 |
48 | Breast hypoplasia (HP:0003187) | 2.85652003 |
49 | Glomerulonephritis (HP:0000099) | 2.84339529 |
50 | Joint hemorrhage (HP:0005261) | 2.76872803 |
51 | Fat malabsorption (HP:0002630) | 2.74223444 |
52 | Hyperbilirubinemia (HP:0002904) | 2.73387958 |
53 | Generalized aminoaciduria (HP:0002909) | 2.73255075 |
54 | Thin bony cortex (HP:0002753) | 2.72493481 |
55 | Abnormality of serum amino acid levels (HP:0003112) | 2.71596842 |
56 | Lethargy (HP:0001254) | 2.70634359 |
57 | Increased purine levels (HP:0004368) | 2.67613295 |
58 | Hyperuricemia (HP:0002149) | 2.67613295 |
59 | Myocardial infarction (HP:0001658) | 2.67612119 |
60 | Delayed CNS myelination (HP:0002188) | 2.65651708 |
61 | Hypertriglyceridemia (HP:0002155) | 2.62447059 |
62 | Decreased electroretinogram (ERG) amplitude (HP:0000654) | 2.60938991 |
63 | Myoglobinuria (HP:0002913) | 2.60776183 |
64 | Akinesia (HP:0002304) | 2.59668533 |
65 | Proximal tubulopathy (HP:0000114) | 2.56905171 |
66 | Malnutrition (HP:0004395) | 2.55526066 |
67 | Widely patent fontanelles and sutures (HP:0004492) | 2.55144363 |
68 | Microretrognathia (HP:0000308) | 2.52071103 |
69 | Abnormality of methionine metabolism (HP:0010901) | 2.51969616 |
70 | Abnormality of the intrinsic pathway (HP:0010989) | 2.47550612 |
71 | Vomiting (HP:0002013) | 2.47255610 |
72 | Skin nodule (HP:0200036) | 2.44370249 |
73 | Cholelithiasis (HP:0001081) | 2.43170324 |
74 | Oligomenorrhea (HP:0000876) | 2.42661336 |
75 | Nausea (HP:0002018) | 2.39821277 |
76 | Hepatocellular carcinoma (HP:0001402) | 2.39772748 |
77 | Neonatal onset (HP:0003623) | 2.35967367 |
78 | Late onset (HP:0003584) | 2.35285418 |
79 | Sensorimotor neuropathy (HP:0007141) | 2.33598572 |
80 | Spontaneous abortion (HP:0005268) | 2.32627631 |
81 | Abnormal gallbladder morphology (HP:0012437) | 2.32223899 |
82 | Nephritis (HP:0000123) | 2.31989276 |
83 | Acanthocytosis (HP:0001927) | 2.31800160 |
84 | Cerebral edema (HP:0002181) | 2.30913871 |
85 | Vascular calcification (HP:0004934) | 2.30857208 |
86 | Recurrent gram-negative bacterial infections (HP:0005420) | 2.30001844 |
87 | Cerebral palsy (HP:0100021) | 2.27275129 |
88 | Pancreatitis (HP:0001733) | 2.26361926 |
89 | Hypophosphatemic rickets (HP:0004912) | 2.25686871 |
90 | Renal Fanconi syndrome (HP:0001994) | 2.24532495 |
91 | Acanthosis nigricans (HP:0000956) | 2.24351524 |
92 | Increased intramyocellular lipid droplets (HP:0012240) | 2.22864051 |
93 | Joint stiffness (HP:0001387) | 2.21290762 |
94 | Ileus (HP:0002595) | 2.20526609 |
95 | Purpura (HP:0000979) | 2.19627450 |
96 | Decreased central vision (HP:0007663) | 2.19501339 |
97 | Conjugated hyperbilirubinemia (HP:0002908) | 2.18672629 |
98 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.18540761 |
99 | Annular pancreas (HP:0001734) | 2.18156675 |
100 | Abnormal cartilage morphology (HP:0002763) | 2.17234254 |
101 | Irritability (HP:0000737) | 2.16376001 |
102 | Cardiovascular calcification (HP:0011915) | 2.16308252 |
103 | Systemic lupus erythematosus (HP:0002725) | 2.15065420 |
104 | Abnormal urine phosphate concentration (HP:0012599) | 2.12389095 |
105 | Abnormality of urine glucose concentration (HP:0011016) | 2.10794694 |
106 | Glycosuria (HP:0003076) | 2.10794694 |
107 | Dysostosis multiplex (HP:0000943) | 2.10022356 |
108 | Spastic diplegia (HP:0001264) | 2.08438668 |
109 | Pustule (HP:0200039) | 2.07303966 |
110 | Abnormality of pyrimidine metabolism (HP:0004353) | 2.07260854 |
111 | Abnormal gallbladder physiology (HP:0012438) | 2.04800530 |
112 | Cholecystitis (HP:0001082) | 2.04800530 |
113 | Right ventricular cardiomyopathy (HP:0011663) | 2.04696508 |
114 | Vaginal fistula (HP:0004320) | 2.04375618 |
115 | Hemorrhage of the eye (HP:0011885) | 2.03787954 |
116 | Facial diplegia (HP:0001349) | 2.03506576 |
117 | Hypochromic anemia (HP:0001931) | 2.02869190 |
118 | Myositis (HP:0100614) | 2.01258915 |
119 | Gastrointestinal infarctions (HP:0005244) | 2.00074067 |
120 | Rib fusion (HP:0000902) | 1.95261140 |
121 | Amyloidosis (HP:0011034) | 1.95172588 |
122 | Brushfield spots (HP:0001088) | 1.94938503 |
123 | Alkalosis (HP:0001948) | 1.93682034 |
124 | Abnormal albumin level (HP:0012116) | 1.93574907 |
125 | Hypoalbuminemia (HP:0003073) | 1.93574907 |
126 | Atrioventricular block (HP:0001678) | 1.92653404 |
127 | Poikilocytosis (HP:0004447) | 1.92433112 |
128 | Rhabdomyolysis (HP:0003201) | 1.91292158 |
129 | Nephrolithiasis (HP:0000787) | 1.90923787 |
130 | Polycythemia (HP:0001901) | 1.90022323 |
131 | Delayed epiphyseal ossification (HP:0002663) | 1.88548559 |
132 | Lipid accumulation in hepatocytes (HP:0006561) | 1.87916366 |
133 | Chronic mucocutaneous candidiasis (HP:0002728) | 1.85033358 |
134 | Recurrent cutaneous fungal infections (HP:0011370) | 1.85033358 |
135 | Pigmentary retinal degeneration (HP:0001146) | 1.84001733 |
136 | Hyperphosphaturia (HP:0003109) | 1.83333742 |
137 | Abnormality of the gallbladder (HP:0005264) | 1.82865906 |
138 | Increased muscle lipid content (HP:0009058) | 1.82843643 |
139 | Abnormality of the Achilles tendon (HP:0005109) | 1.82482570 |
140 | Reticulocytosis (HP:0001923) | 1.82231209 |
141 | J-shaped sella turcica (HP:0002680) | 1.81439630 |
142 | Hypoglycemic seizures (HP:0002173) | 1.80716458 |
143 | Epistaxis (HP:0000421) | 1.80182209 |
144 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 1.79921312 |
145 | Increased hepatocellular lipid droplets (HP:0006565) | 1.79797303 |
146 | Abnormality of the vitreous humor (HP:0004327) | 1.79413518 |
147 | Abnormality of iron homeostasis (HP:0011031) | 1.79080945 |
148 | Steatorrhea (HP:0002570) | 1.76065746 |
149 | Patellar aplasia (HP:0006443) | 1.76041478 |
150 | Agammaglobulinemia (HP:0004432) | 1.75193622 |
151 | Cheilitis (HP:0100825) | 1.74572271 |
152 | Mitral stenosis (HP:0001718) | 1.73765792 |
153 | Increased serum ferritin (HP:0003281) | 1.72660750 |
154 | Dyschromatopsia (HP:0007641) | 1.72456181 |
155 | Axonal loss (HP:0003447) | 1.72235733 |
156 | Hypophosphatemia (HP:0002148) | 1.71603919 |
157 | Status epilepticus (HP:0002133) | 1.71304378 |
158 | Rickets (HP:0002748) | 1.71204129 |
159 | Abnormality of transition element cation homeostasis (HP:0011030) | 1.68608052 |
160 | Orchitis (HP:0100796) | 1.68231667 |
161 | Methylmalonic aciduria (HP:0012120) | 1.67370571 |
Rank | Gene Set | Z-score |
---|---|---|
1 | BCKDK | 5.66829749 |
2 | TESK2 | 4.42566966 |
3 | TRIB3 | 3.99893101 |
4 | SIK1 | 3.62640246 |
5 | ERN1 | 3.60653660 |
6 | ACVR1B | 3.44612943 |
7 | MAPK15 | 3.27815662 |
8 | MST1R | 2.90719225 |
9 | FGFR4 | 2.75464153 |
10 | MAP4K1 | 2.72815413 |
11 | CAMK1D | 2.24859139 |
12 | PDK4 | 2.17393199 |
13 | PDK3 | 2.17393199 |
14 | LMTK2 | 2.11523593 |
15 | RIPK1 | 1.91443346 |
16 | PKN2 | 1.89136990 |
17 | DAPK2 | 1.68309718 |
18 | TNK2 | 1.64211037 |
19 | TLK1 | 1.60588772 |
20 | WNK4 | 1.56749217 |
21 | FRK | 1.53122525 |
22 | BMPR1B | 1.51493944 |
23 | RIPK4 | 1.47932343 |
24 | MAP2K4 | 1.45407493 |
25 | CAMK1G | 1.40166634 |
26 | BLK | 1.34188742 |
27 | PRKD2 | 1.32176690 |
28 | PINK1 | 1.32066148 |
29 | MAPK11 | 1.30521256 |
30 | KSR2 | 1.26904924 |
31 | PRKAA2 | 1.26242047 |
32 | NEK1 | 1.20543803 |
33 | TAOK3 | 1.19786441 |
34 | PDK2 | 1.16509438 |
35 | MAP4K2 | 1.15935584 |
36 | DYRK1B | 1.15770517 |
37 | PTK6 | 1.13586121 |
38 | INSRR | 1.12754049 |
39 | GRK6 | 1.12728577 |
40 | NEK9 | 1.11662935 |
41 | ARAF | 1.10798928 |
42 | ZAP70 | 1.10674474 |
43 | MAP2K1 | 1.09237299 |
44 | GRK1 | 1.07446521 |
45 | MYLK | 1.01432666 |
46 | SYK | 1.00520135 |
47 | MAPKAPK3 | 0.99298196 |
48 | PDPK1 | 0.99142958 |
49 | MAP3K7 | 0.97563275 |
50 | TXK | 0.97432744 |
51 | MARK2 | 0.95554946 |
52 | IKBKB | 0.93679600 |
53 | GRK5 | 0.92973432 |
54 | JAK2 | 0.92605808 |
55 | FER | 0.92201798 |
56 | MAP3K2 | 0.92033293 |
57 | ZAK | 0.90544010 |
58 | PDGFRA | 0.90534644 |
59 | MAP3K9 | 0.89787658 |
60 | MAP2K2 | 0.88694708 |
61 | PIM2 | 0.88686284 |
62 | PRPF4B | 0.88443924 |
63 | NME1 | 0.88203751 |
64 | MAP3K3 | 0.87585771 |
65 | CAMKK2 | 0.85767834 |
66 | JAK1 | 0.84632681 |
67 | MAP3K13 | 0.83983112 |
68 | TYK2 | 0.83208228 |
69 | RET | 0.82872568 |
70 | CDC42BPA | 0.82427373 |
71 | MET | 0.82246161 |
72 | STK38L | 0.81891599 |
73 | PRKAA1 | 0.81057644 |
74 | SGK3 | 0.80720341 |
75 | BTK | 0.79676085 |
76 | TTN | 0.79562182 |
77 | ADRBK2 | 0.79484204 |
78 | ADRBK1 | 0.78723612 |
79 | SMG1 | 0.77706629 |
80 | TAOK1 | 0.76410953 |
81 | STK38 | 0.76376150 |
82 | PDK1 | 0.75541954 |
83 | FGFR3 | 0.75095297 |
84 | CSF1R | 0.74125990 |
85 | MAP2K3 | 0.73251096 |
86 | RPS6KA6 | 0.72955852 |
87 | WNK3 | 0.72688457 |
88 | MAP3K11 | 0.72511590 |
89 | LATS1 | 0.71677632 |
90 | ABL2 | 0.71291136 |
91 | LRRK2 | 0.70936267 |
92 | PIK3CG | 0.70603941 |
93 | PRKACG | 0.69376826 |
94 | PTK2 | 0.69355287 |
95 | MUSK | 0.69333889 |
96 | TGFBR2 | 0.69328649 |
97 | IKBKE | 0.68551511 |
98 | MAPK12 | 0.67648251 |
99 | ITK | 0.67234121 |
100 | LATS2 | 0.67106838 |
101 | SIK3 | 0.66450512 |
102 | FGFR2 | 0.66269433 |
103 | PHKG1 | 0.65079020 |
104 | PHKG2 | 0.65079020 |
105 | FES | 0.64482970 |
106 | KDR | 0.64285991 |
107 | ERBB4 | 0.64103472 |
108 | WNK1 | 0.63020248 |
109 | PRKCZ | 0.62913288 |
110 | ICK | 0.61880832 |
111 | PRKCH | 0.61675533 |
112 | TIE1 | 0.59877954 |
113 | LYN | 0.59084399 |
114 | SGK494 | 0.58964711 |
115 | SGK223 | 0.58964711 |
116 | CSK | 0.58824151 |
117 | EPHB1 | 0.58349655 |
118 | EPHA4 | 0.57712913 |
119 | PRKCQ | 0.57670176 |
120 | HIPK2 | 0.57523803 |
121 | BMX | 0.57135387 |
122 | NTRK1 | 0.56337756 |
123 | KIT | 0.55893251 |
124 | IRAK4 | 0.54286604 |
125 | CAMKK1 | 0.54108951 |
126 | LCK | 0.54061351 |
127 | MAP3K1 | 0.54018810 |
128 | EPHB2 | 0.53999664 |
129 | MAP2K6 | 0.53527120 |
130 | EPHA2 | 0.52302104 |
131 | OXSR1 | 0.52235422 |
132 | PTK2B | 0.52235157 |
133 | JAK3 | 0.52206255 |
134 | RPS6KL1 | 0.52094230 |
135 | RPS6KC1 | 0.52094230 |
136 | SIK2 | 0.50585065 |
137 | FLT3 | 0.50348471 |
138 | PRKG2 | 0.49364695 |
139 | CDK6 | 0.48775735 |
140 | MAP3K10 | 0.48472548 |
141 | SGK2 | 0.47623946 |
142 | CAMK1 | 0.47545443 |
143 | TGFBR1 | 0.47496507 |
144 | CASK | 0.45349240 |
145 | AKT3 | 0.44950358 |
146 | GSK3A | 0.44690259 |
147 | TBK1 | 0.43404735 |
148 | CAMK2G | 0.42499952 |
149 | MAP3K14 | 0.42176642 |
150 | RPS6KA2 | 0.41052026 |
151 | CDK4 | 0.39528816 |
152 | DAPK1 | 0.39440660 |
153 | PRKD1 | 0.39075102 |
154 | CAMK4 | 0.37904650 |
155 | IRAK3 | 0.36762479 |
156 | HCK | 0.35526958 |
157 | MAPK4 | 0.34354085 |
158 | MTOR | 0.34144001 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 3.33359025 |
2 | Nitrogen metabolism_Homo sapiens_hsa00910 | 3.07457851 |
3 | Fatty acid degradation_Homo sapiens_hsa00071 | 2.91273450 |
4 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 2.89528650 |
5 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 2.83508968 |
6 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 2.81067660 |
7 | Propanoate metabolism_Homo sapiens_hsa00640 | 2.78974931 |
8 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 2.75627174 |
9 | Arginine biosynthesis_Homo sapiens_hsa00220 | 2.62130227 |
10 | PPAR signaling pathway_Homo sapiens_hsa03320 | 2.53903710 |
11 | Tryptophan metabolism_Homo sapiens_hsa00380 | 2.41463550 |
12 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 2.36509504 |
13 | Fatty acid metabolism_Homo sapiens_hsa01212 | 2.36012246 |
14 | Butanoate metabolism_Homo sapiens_hsa00650 | 2.31988228 |
15 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 2.25943788 |
16 | Peroxisome_Homo sapiens_hsa04146 | 2.13974976 |
17 | Pyruvate metabolism_Homo sapiens_hsa00620 | 2.01163947 |
18 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 1.98854047 |
19 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 1.98418163 |
20 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 1.97234316 |
21 | Other glycan degradation_Homo sapiens_hsa00511 | 1.90420878 |
22 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 1.89142831 |
23 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 1.88434158 |
24 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 1.83000213 |
25 | Complement and coagulation cascades_Homo sapiens_hsa04610 | 1.77726791 |
26 | Caffeine metabolism_Homo sapiens_hsa00232 | 1.65248251 |
27 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 1.64741049 |
28 | Carbon metabolism_Homo sapiens_hsa01200 | 1.58766531 |
29 | Bile secretion_Homo sapiens_hsa04976 | 1.55547608 |
30 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 1.53531340 |
31 | Fat digestion and absorption_Homo sapiens_hsa04975 | 1.52562889 |
32 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.49382429 |
33 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 1.47839977 |
34 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 1.46509291 |
35 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 1.45288691 |
36 | Histidine metabolism_Homo sapiens_hsa00340 | 1.44553428 |
37 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 1.42428258 |
38 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 1.37601731 |
39 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 1.37452872 |
40 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 1.34832490 |
41 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 1.34139897 |
42 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 1.29926935 |
43 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.29394168 |
44 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 1.28606243 |
45 | Primary immunodeficiency_Homo sapiens_hsa05340 | 1.23525946 |
46 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 1.21828738 |
47 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.21818152 |
48 | Tyrosine metabolism_Homo sapiens_hsa00350 | 1.21295541 |
49 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 1.18966373 |
50 | Retinol metabolism_Homo sapiens_hsa00830 | 1.17805192 |
51 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 1.13774054 |
52 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.08246561 |
53 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 1.06480867 |
54 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.05207040 |
55 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.02802046 |
56 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 1.02667337 |
57 | ABC transporters_Homo sapiens_hsa02010 | 0.98674118 |
58 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.98199843 |
59 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.97908940 |
60 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.92281230 |
61 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.88793475 |
62 | Sulfur relay system_Homo sapiens_hsa04122 | 0.85304608 |
63 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.85140955 |
64 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.83249145 |
65 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.81792637 |
66 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.80678641 |
67 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.75483455 |
68 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.75231426 |
69 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.72072974 |
70 | Lysine degradation_Homo sapiens_hsa00310 | 0.71908323 |
71 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.71011259 |
72 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.66481654 |
73 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.64924852 |
74 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.61643869 |
75 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.57512859 |
76 | Insulin resistance_Homo sapiens_hsa04931 | 0.53032397 |
77 | Galactose metabolism_Homo sapiens_hsa00052 | 0.49331288 |
78 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.49186723 |
79 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.48527720 |
80 | Allograft rejection_Homo sapiens_hsa05330 | 0.48465108 |
81 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.47235567 |
82 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.45679854 |
83 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.45605370 |
84 | Metabolic pathways_Homo sapiens_hsa01100 | 0.43164193 |
85 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.42659800 |
86 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.39534191 |
87 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.38322404 |
88 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.33281504 |
89 | Pertussis_Homo sapiens_hsa05133 | 0.33104098 |
90 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.32637952 |
91 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.32031453 |
92 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.31330506 |
93 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.28319544 |
94 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.28154390 |
95 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 0.27192815 |
96 | Phototransduction_Homo sapiens_hsa04744 | 0.26988029 |
97 | Asthma_Homo sapiens_hsa05310 | 0.26793687 |
98 | Protein digestion and absorption_Homo sapiens_hsa04974 | 0.25868606 |
99 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.24620185 |
100 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.24595321 |
101 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 0.24528708 |
102 | Renin-angiotensin system_Homo sapiens_hsa04614 | 0.24347528 |
103 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.23015461 |
104 | Mineral absorption_Homo sapiens_hsa04978 | 0.22439866 |
105 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.21698019 |
106 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.21419814 |
107 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.20823562 |
108 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.19332927 |
109 | Circadian rhythm_Homo sapiens_hsa04710 | 0.16697690 |
110 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.14028327 |
111 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.13209033 |
112 | Prion diseases_Homo sapiens_hsa05020 | 0.10676737 |
113 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.10394837 |
114 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 0.10336585 |
115 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.06087574 |
116 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | -0.0958629 |
117 | Collecting duct acid secretion_Homo sapiens_hsa04966 | -0.0952347 |
118 | Renin secretion_Homo sapiens_hsa04924 | -0.0944941 |
119 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | -0.0886188 |
120 | Parkinsons disease_Homo sapiens_hsa05012 | -0.0875853 |
121 | Lysosome_Homo sapiens_hsa04142 | -0.0751718 |
122 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | -0.0728775 |
123 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | -0.0722933 |
124 | Oxidative phosphorylation_Homo sapiens_hsa00190 | -0.0662568 |
125 | Bladder cancer_Homo sapiens_hsa05219 | -0.0625618 |
126 | Linoleic acid metabolism_Homo sapiens_hsa00591 | -0.0261133 |
127 | Type II diabetes mellitus_Homo sapiens_hsa04930 | -0.0194834 |