ACCSL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of acrosome reaction (GO:0060046)9.27001691
2multicellular organism reproduction (GO:0032504)7.47096527
3retinal cone cell development (GO:0046549)7.39024747
4positive regulation of histone H3-K4 methylation (GO:0051571)7.27899558
5oocyte development (GO:0048599)7.22825905
6regulation of histone H3-K9 methylation (GO:0051570)7.19320001
7mitotic metaphase plate congression (GO:0007080)6.75195645
8regulation of meiosis (GO:0040020)6.40387809
9regulation of female gonad development (GO:2000194)6.33823286
10piRNA metabolic process (GO:0034587)6.21440007
11regulation of attachment of spindle microtubules to kinetochore (GO:0051988)6.12834548
12protein kinase C signaling (GO:0070528)6.11203945
13negative regulation of reproductive process (GO:2000242)6.01456876
14female gamete generation (GO:0007292)6.01162331
15regulation of steroid hormone secretion (GO:2000831)5.87760336
16negative regulation of retinoic acid receptor signaling pathway (GO:0048387)5.87736168
17glycine transport (GO:0015816)5.74727792
18regulation of meiosis I (GO:0060631)5.72695683
19mitotic chromosome condensation (GO:0007076)5.57507840
20positive regulation of humoral immune response (GO:0002922)5.55341545
21negative regulation of meiosis (GO:0045835)5.51647443
22metaphase plate congression (GO:0051310)5.50849913
23meiotic cell cycle (GO:0051321)5.50051116
24positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.46243728
25regulation of exit from mitosis (GO:0007096)5.27921297
26attachment of spindle microtubules to kinetochore (GO:0008608)5.26307022
27negative regulation of hormone biosynthetic process (GO:0032353)5.22166282
28negative regulation of hormone metabolic process (GO:0032351)5.22166282
29maturation of 5.8S rRNA (GO:0000460)5.20223458
30regulation of histone H3-K27 methylation (GO:0061085)5.09755012
31regulation of meiotic cell cycle (GO:0051445)5.05204777
32oocyte maturation (GO:0001556)5.02349825
33positive regulation of gastrulation (GO:2000543)4.95519102
34reproduction (GO:0000003)4.95431534
35mitotic sister chromatid segregation (GO:0000070)4.95223664
36establishment of chromosome localization (GO:0051303)4.93740025
37histone H2A monoubiquitination (GO:0035518)4.79406439
38DNA damage induced protein phosphorylation (GO:0006975)4.72013514
39regulation of sister chromatid cohesion (GO:0007063)4.65391647
40DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla4.61050471
41centriole replication (GO:0007099)4.60740907
42male meiosis (GO:0007140)4.58941149
43regulation of RIG-I signaling pathway (GO:0039535)4.58846382
44regulation of retinoic acid receptor signaling pathway (GO:0048385)4.58718937
45protein localization to kinetochore (GO:0034501)4.56817988
46positive regulation of histone methylation (GO:0031062)4.56474909
47negative regulation of meiotic cell cycle (GO:0051447)4.55979079
48DNA damage response, signal transduction resulting in transcription (GO:0042772)4.55499647
49meiotic chromosome segregation (GO:0045132)4.45908422
50protein localization to chromosome, centromeric region (GO:0071459)4.42800888
51regulation of spindle organization (GO:0090224)4.41785904
52regulation of histone H3-K4 methylation (GO:0051569)4.39476712
53glycerophospholipid catabolic process (GO:0046475)4.38016969
54citrulline biosynthetic process (GO:0019240)4.33023945
55regulation of DNA methylation (GO:0044030)4.32633384
56primitive streak formation (GO:0090009)4.30264840
57positive regulation of reproductive process (GO:2000243)4.21817131
58monoubiquitinated protein deubiquitination (GO:0035520)4.21455876
59regulation of glucocorticoid metabolic process (GO:0031943)4.20175924
60protein localization to chromosome (GO:0034502)4.19322711
61regulation of mitotic spindle organization (GO:0060236)4.18925374
62positive regulation of megakaryocyte differentiation (GO:0045654)4.16230045
63L-amino acid import (GO:0043092)4.14618013
64histone H2A ubiquitination (GO:0033522)4.14609704
65negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)4.08748572
66negative regulation of DNA-templated transcription, elongation (GO:0032785)4.08748572
67positive regulation of chromosome segregation (GO:0051984)4.07378850
68phosphorelay signal transduction system (GO:0000160)4.02359930
69binding of sperm to zona pellucida (GO:0007339)4.01543380
70CENP-A containing nucleosome assembly (GO:0034080)3.99438230
71sister chromatid segregation (GO:0000819)3.98702477
72phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.97408182
73protein K6-linked ubiquitination (GO:0085020)3.94898831
74chromosome segregation (GO:0007059)3.94434393
75regulation of histone methylation (GO:0031060)3.93362964
76fertilization (GO:0009566)3.92298966
77DNA methylation involved in gamete generation (GO:0043046)3.91929759
78synapsis (GO:0007129)3.89316123
79chromatin remodeling at centromere (GO:0031055)3.85432480
80regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.83264193
81type B pancreatic cell development (GO:0003323)3.79952999
82regulation of transforming growth factor beta2 production (GO:0032909)3.79155399
83synaptonemal complex assembly (GO:0007130)3.78544415
84female gonad development (GO:0008585)3.77697212
85DNA replication-independent nucleosome organization (GO:0034724)3.75953517
86DNA replication-independent nucleosome assembly (GO:0006336)3.75953517
87regulation of chromosome segregation (GO:0051983)3.75898759
88negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.71996459
89negative regulation of execution phase of apoptosis (GO:1900118)3.71968972
90positive regulation of DNA-dependent DNA replication (GO:2000105)3.71582460
91spindle checkpoint (GO:0031577)3.70096424
92mitotic nuclear envelope disassembly (GO:0007077)3.68544810
93negative regulation of smooth muscle cell differentiation (GO:0051151)3.66708738
94single fertilization (GO:0007338)3.64840136
95histone exchange (GO:0043486)3.63764221
96DNA replication checkpoint (GO:0000076)3.59469472
97regulation of corticosteroid hormone secretion (GO:2000846)3.59221915
98regulation of reproductive process (GO:2000241)3.58335409
99positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.57241302
100positive regulation of mitotic sister chromatid separation (GO:1901970)3.57241302
101positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.57241302
102positive regulation of uterine smooth muscle contraction (GO:0070474)3.56161708
103snRNA transcription (GO:0009301)3.55749239
104regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.55581544
105positive regulation of endothelial cell differentiation (GO:0045603)3.54609792
106negative regulation of histone modification (GO:0031057)3.52262223
107microtubule severing (GO:0051013)3.50734377
108membrane disassembly (GO:0030397)3.48489811
109nuclear envelope disassembly (GO:0051081)3.48489811
110chromosome organization involved in meiosis (GO:0070192)3.44796857
111relaxation of smooth muscle (GO:0044557)3.43980264
112oogenesis (GO:0048477)3.43270945
113microtubule nucleation (GO:0007020)3.42804755
114gene silencing (GO:0016458)3.41839668
115positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)3.41539814
116positive regulation of hormone biosynthetic process (GO:0046886)3.39345097
117synaptonemal complex organization (GO:0070193)3.35187324
118negative regulation of alcohol biosynthetic process (GO:1902931)3.32623817
119regulation of calcium ion-dependent exocytosis (GO:0017158)3.32070272
120mitotic spindle checkpoint (GO:0071174)3.31224117
121translesion synthesis (GO:0019985)3.29440195
122DNA replication-dependent nucleosome assembly (GO:0006335)3.29326922
123DNA replication-dependent nucleosome organization (GO:0034723)3.29326922
124interkinetic nuclear migration (GO:0022027)3.28521724
125chromatin assembly or disassembly (GO:0006333)3.27594770
126labyrinthine layer development (GO:0060711)3.26230146
127mitotic sister chromatid cohesion (GO:0007064)3.24892260
128sperm-egg recognition (GO:0035036)3.23712288
129positive regulation of steroid hormone secretion (GO:2000833)3.22815940
130kinetochore assembly (GO:0051382)3.22134670
131stress granule assembly (GO:0034063)3.22014356
132gene silencing by RNA (GO:0031047)3.21783967
133N-terminal protein amino acid acetylation (GO:0006474)3.21615707
134male meiosis I (GO:0007141)3.20148168
135chromatin assembly (GO:0031497)3.18719330
136meiosis I (GO:0007127)3.18615741
137meiotic nuclear division (GO:0007126)3.18222798
138neuron fate determination (GO:0048664)3.17438311
139sister chromatid cohesion (GO:0007062)3.16920497
140regulation of chromatin silencing (GO:0031935)3.16709073
141negative regulation of nuclear division (GO:0051784)3.16366890
142regulation of mononuclear cell migration (GO:0071675)3.15683702
143regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.15069996
144cytoplasmic mRNA processing body assembly (GO:0033962)3.14729884
145notochord development (GO:0030903)3.13531642
146meiotic cell cycle process (GO:1903046)3.13390043
147negative regulation of chromosome segregation (GO:0051985)3.13233547
148regulation of cell maturation (GO:1903429)3.13188521
149DNA methylation (GO:0006306)3.13023060
150DNA alkylation (GO:0006305)3.13023060
151negative regulation of cell division (GO:0051782)3.12847948
152negative regulation of histone methylation (GO:0031061)3.12230504
153regulation of spindle checkpoint (GO:0090231)3.11794959
154negative regulation of chromatin modification (GO:1903309)3.11330620
155centriole assembly (GO:0098534)3.10487559
156regulation of steroid hormone biosynthetic process (GO:0090030)3.09567270
157positive regulation of meiosis (GO:0045836)3.09164693
158somite rostral/caudal axis specification (GO:0032525)3.06211350
159negative regulation of mitotic sister chromatid segregation (GO:0033048)3.05319674
160negative regulation of sister chromatid segregation (GO:0033046)3.05319674
161histone phosphorylation (GO:0016572)3.04562474
162regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00433.04380481

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human6.53394695
2E2F7_22180533_ChIP-Seq_HELA_Human5.08256950
3FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.47857208
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.09477833
5KAP1_22055183_ChIP-Seq_ESCs_Mouse4.08298529
6BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.94233972
7AR_21909140_ChIP-Seq_LNCAP_Human3.80476481
8SMAD_19615063_ChIP-ChIP_OVARY_Human3.73174006
9SALL1_21062744_ChIP-ChIP_HESCs_Human3.45435211
10NANOG_18700969_ChIP-ChIP_MESCs_Mouse3.40420817
11MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.18916127
12KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.98106997
13KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.98106997
14KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.98106997
15E2F4_17652178_ChIP-ChIP_JURKAT_Human2.66418577
16HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.66012037
17GATA1_26923725_Chip-Seq_HPCs_Mouse2.52929758
18E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.41306416
19TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.13434144
20GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.11812469
21GBX2_23144817_ChIP-Seq_PC3_Human2.07159594
22EZH2_22144423_ChIP-Seq_EOC_Human16.1432197
23NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.95564446
24RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.94044631
25STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.87408718
26NOTCH1_21737748_ChIP-Seq_TLL_Human1.84237728
27KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.83385923
28RUNX1_26923725_Chip-Seq_HPCs_Mouse1.81693547
29E2F1_21310950_ChIP-Seq_MCF-7_Human1.76030495
30FLI1_27457419_Chip-Seq_LIVER_Mouse1.75948691
31SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.72277499
32LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.69644962
33SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.58179000
34MYC_18940864_ChIP-ChIP_HL60_Human1.56046474
35MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.55311239
36TP63_19390658_ChIP-ChIP_HaCaT_Human1.50448462
37IGF1R_20145208_ChIP-Seq_DFB_Human1.48248234
38CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.42159401
39NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.41636359
40PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.35706874
41MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.35515427
42NANOG_18555785_ChIP-Seq_MESCs_Mouse1.34470728
43PCGF2_27294783_Chip-Seq_ESCs_Mouse1.32393255
44EP300_21415370_ChIP-Seq_HL-1_Mouse1.32351991
45MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.31864646
46AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.31470187
47BP1_19119308_ChIP-ChIP_Hs578T_Human1.31401682
48SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.31259661
49TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.30549469
50FUS_26573619_Chip-Seq_HEK293_Human1.28518262
51RNF2_27304074_Chip-Seq_NSC_Mouse1.28397422
52MYCN_18555785_ChIP-Seq_MESCs_Mouse1.28372972
53POU3F2_20337985_ChIP-ChIP_501MEL_Human1.27430013
54ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.26822170
55STAT6_21828071_ChIP-Seq_BEAS2B_Human1.25306243
56HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.25171641
57NANOG_21062744_ChIP-ChIP_HESCs_Human1.24677430
58UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.21125353
59TCF4_23295773_ChIP-Seq_U87_Human1.19275588
60RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.16468947
61TCF3_18692474_ChIP-Seq_MESCs_Mouse1.16384346
62TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.16288093
63TOP2B_26459242_ChIP-Seq_MCF-7_Human1.15924837
64AR_25329375_ChIP-Seq_VCAP_Human1.15045788
65PRDM14_20953172_ChIP-Seq_ESCs_Human1.14709590
66CBP_20019798_ChIP-Seq_JUKART_Human1.14379493
67IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.14379493
68KAP1_27257070_Chip-Seq_ESCs_Mouse1.14135880
69SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13272984
70CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.13125797
71CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.12471232
72ELK4_26923725_Chip-Seq_MESODERM_Mouse1.12367804
73STAT1_17558387_ChIP-Seq_HELA_Human1.12278148
74AUTS2_25519132_ChIP-Seq_293T-REX_Human1.11194849
75FOXM1_26456572_ChIP-Seq_MCF-7_Human1.10842146
76PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.10802823
77TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.09414796
78IRF1_19129219_ChIP-ChIP_H3396_Human1.09244939
79KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.08820326
80GATA1_19941827_ChIP-Seq_MEL86_Mouse1.08617941
81LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07250517
82KLF4_18555785_ChIP-Seq_MESCs_Mouse1.06956197
83CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.06623525
84GF1_26923725_Chip-Seq_HPCs_Mouse1.06424438
85SMAD4_21741376_ChIP-Seq_EPCs_Human1.05949348
86CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.05937513
87NANOG_18555785_Chip-Seq_ESCs_Mouse1.04152530
88* CDX2_22108803_ChIP-Seq_LS180_Human1.03946965
89ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.02900740
90ERG_20517297_ChIP-Seq_VCAP_Human1.02559461
91NANOG_20526341_ChIP-Seq_ESCs_Human1.01098006
92HTT_18923047_ChIP-ChIP_STHdh_Human1.01046745
93SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.99637054
94POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.98205546
95TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98205546
96SUZ12_27294783_Chip-Seq_NPCs_Mouse0.98033375
97GATA3_21867929_ChIP-Seq_TH1_Mouse0.97846693
98* SMAD4_21799915_ChIP-Seq_A2780_Human0.97221475
99TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.96996243
100CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.96280928
101TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.94499013
102* STAT3_23295773_ChIP-Seq_U87_Human0.93633346
103EWS_26573619_Chip-Seq_HEK293_Human0.91927522
104E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.91545914
105POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.91293278
106RBPJ_22232070_ChIP-Seq_NCS_Mouse0.90684606
107NFYA_21822215_ChIP-Seq_K562_Human0.90658168
108EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.90407481
109ESR1_20079471_ChIP-ChIP_T-47D_Human0.90342902
110FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.85744985
111* RUNX2_22187159_ChIP-Seq_PCA_Human0.85677454
112FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.85533757
113PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.84585132
114DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.84296468
115SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.84076644
116SMRT_27268052_Chip-Seq_Bcells_Human0.83675887
117TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.82716701
118KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.82528355
119GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.81511860
120SALL4_22934838_ChIP-ChIP_CD34+_Human0.81311939
121TBL1_22424771_ChIP-Seq_293T_Human0.81025134
122TAL1_26923725_Chip-Seq_HPCs_Mouse0.80894512
123NFE2_27457419_Chip-Seq_LIVER_Mouse0.79952670
124SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.79151470
125GF1B_26923725_Chip-Seq_HPCs_Mouse0.78372317
126CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.78219608
127SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77580431
128NANOG_18692474_ChIP-Seq_MESCs_Mouse0.77377405
129STAT3_18555785_ChIP-Seq_MESCs_Mouse0.77224002
130AHR_22903824_ChIP-Seq_MCF-7_Human0.77019081
131PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.76900505
132FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.76143762
133TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.75614605
134FOXH1_21741376_ChIP-Seq_EPCs_Human0.75265367
135FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.74424995
136* CBP_21632823_ChIP-Seq_H3396_Human0.74145043
137FOXO3_23340844_ChIP-Seq_DLD1_Human0.73959621
138PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.73685266
139MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.73293265
140STAT3_18555785_Chip-Seq_ESCs_Mouse0.72973396
141KLF4_19829295_ChIP-Seq_ESCs_Human0.72385086
142FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.72007166
143SALL4_18804426_ChIP-ChIP_XEN_Mouse0.71870481
144SOX2_18555785_Chip-Seq_ESCs_Mouse0.71653191
145P300_19829295_ChIP-Seq_ESCs_Human0.70005223
146ZNF217_24962896_ChIP-Seq_MCF-7_Human0.68001517
147SOX2_21211035_ChIP-Seq_LN229_Gbm0.66755352
148SMAD3_21741376_ChIP-Seq_EPCs_Human0.66415117
149ESR1_15608294_ChIP-ChIP_MCF-7_Human0.66036081
150TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.66020562
151DROSHA_22980978_ChIP-Seq_HELA_Human0.65002805
152ARNT_22903824_ChIP-Seq_MCF-7_Human0.63199658
153TP53_22573176_ChIP-Seq_HFKS_Human0.62811313
154TP53_16413492_ChIP-PET_HCT116_Human0.62579774
155OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.62330118
156* NR3C1_23031785_ChIP-Seq_PC12_Mouse0.61441118
157ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.60977458
158AR_20517297_ChIP-Seq_VCAP_Human0.58740045
159BMI1_23680149_ChIP-Seq_NPCS_Mouse0.58048415
160GATA3_26560356_Chip-Seq_TH1_Human0.57912619
161BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human0.57523811
162GATA3_21878914_ChIP-Seq_MCF-7_Human0.56913475
163PKCTHETA_26484144_Chip-Seq_BREAST_Human0.56903207
164BCAT_22108803_ChIP-Seq_LS180_Human0.56459839

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005451_abnormal_body_composition6.00815942
2MP0003718_maternal_effect5.62768251
3MP0002102_abnormal_ear_morphology5.23443342
4MP0003646_muscle_fatigue4.72548985
5MP0008789_abnormal_olfactory_epithelium4.20584618
6MP0003693_abnormal_embryo_hatching4.11182843
7MP0005394_taste/olfaction_phenotype3.79062751
8MP0005499_abnormal_olfactory_system3.79062751
9MP0002653_abnormal_ependyma_morphology3.63612693
10MP0010094_abnormal_chromosome_stability3.44194015
11MP0008877_abnormal_DNA_methylation3.31039351
12MP0002139_abnormal_hepatobiliary_system3.23392694
13MP0003111_abnormal_nucleus_morphology3.11928495
14MP0003077_abnormal_cell_cycle2.94936339
15MP0003879_abnormal_hair_cell2.82965991
16MP0002138_abnormal_hepatobiliary_system2.67921145
17MP0003123_paternal_imprinting2.67444363
18MP0001119_abnormal_female_reproductive2.66594556
19MP0004957_abnormal_blastocyst_morpholog2.63746118
20MP0005395_other_phenotype2.63047874
21MP0003699_abnormal_female_reproductive2.55697240
22MP0005408_hypopigmentation2.46299546
23MP0005360_urolithiasis2.45718593
24MP0002234_abnormal_pharynx_morphology2.28112195
25MP0006292_abnormal_olfactory_placode2.26681699
26MP0003787_abnormal_imprinting2.17457167
27MP0002249_abnormal_larynx_morphology2.15784485
28MP0001929_abnormal_gametogenesis2.12961442
29MP0000653_abnormal_sex_gland2.12335717
30MP0003183_abnormal_peptide_metabolism2.10369092
31MP0002210_abnormal_sex_determination1.93056637
32MP0003121_genomic_imprinting1.89650732
33MP0005410_abnormal_fertilization1.81140257
34MP0003937_abnormal_limbs/digits/tail_de1.75351174
35MP0008932_abnormal_embryonic_tissue1.72600541
36MP0000462_abnormal_digestive_system1.65914002
37MP0000579_abnormal_nail_morphology1.63980526
38MP0008007_abnormal_cellular_replicative1.61248060
39MP0004185_abnormal_adipocyte_glucose1.57414438
40MP0004264_abnormal_extraembryonic_tissu1.45450302
41MP0002085_abnormal_embryonic_tissue1.44470894
42MP0001145_abnormal_male_reproductive1.43398348
43MP0001529_abnormal_vocalization1.43332698
44MP0009840_abnormal_foam_cell1.41481845
45MP0000350_abnormal_cell_proliferation1.41437915
46MP0002161_abnormal_fertility/fecundity1.41101435
47MP0001730_embryonic_growth_arrest1.39101614
48MP0001697_abnormal_embryo_size1.32533044
49MP0001293_anophthalmia1.31481042
50MP0001915_intracranial_hemorrhage1.30350575
51MP0002084_abnormal_developmental_patter1.24669176
52MP0008057_abnormal_DNA_replication1.23747388
53MP0005310_abnormal_salivary_gland1.23258150
54MP0002160_abnormal_reproductive_system1.23041595
55MP0003252_abnormal_bile_duct1.20468242
56MP0010234_abnormal_vibrissa_follicle1.18737423
57MP0000639_abnormal_adrenal_gland1.17868197
58MP0010368_abnormal_lymphatic_system1.15430441
59MP0004142_abnormal_muscle_tone1.10973877
60MP0005380_embryogenesis_phenotype1.09002564
61MP0001672_abnormal_embryogenesis/_devel1.09002564
62MP0006276_abnormal_autonomic_nervous1.08012835
63MP0000762_abnormal_tongue_morphology1.07519165
64MP0001905_abnormal_dopamine_level1.06010740
65MP0003315_abnormal_perineum_morphology1.04155854
66MP0003136_yellow_coat_color1.03501645
67MP0008058_abnormal_DNA_repair1.02660781
68MP0001664_abnormal_digestion1.01611330
69MP0001984_abnormal_olfaction0.99903960
70MP0010678_abnormal_skin_adnexa0.97834971
71MP0002272_abnormal_nervous_system0.94975645
72MP0005646_abnormal_pituitary_gland0.94742221
73MP0002019_abnormal_tumor_incidence0.94314112
74MP0002877_abnormal_melanocyte_morpholog0.93618039
75MP0001849_ear_inflammation0.91220941
76MP0003119_abnormal_digestive_system0.88995557
77MP0003755_abnormal_palate_morphology0.88094058
78MP0005085_abnormal_gallbladder_physiolo0.86857272
79MP0001986_abnormal_taste_sensitivity0.86806625
80MP0004145_abnormal_muscle_electrophysio0.84214303
81MP0003698_abnormal_male_reproductive0.83721041
82MP0004510_myositis0.82946265
83MP0008260_abnormal_autophagy0.81327304
84MP0005551_abnormal_eye_electrophysiolog0.79243450
85MP0000490_abnormal_crypts_of0.79051682
86MP0003984_embryonic_growth_retardation0.78248369
87MP0005464_abnormal_platelet_physiology0.78000362
88MP0000015_abnormal_ear_pigmentation0.77897089
89MP0010307_abnormal_tumor_latency0.76632650
90MP0001666_abnormal_nutrient_absorption0.75523429
91MP0001346_abnormal_lacrimal_gland0.75185743
92MP0005621_abnormal_cell_physiology0.74629429
93MP0001851_eye_inflammation0.74604923
94MP0005647_abnormal_sex_gland0.74109560
95MP0009250_abnormal_appendicular_skeleto0.74045538
96MP0003453_abnormal_keratinocyte_physiol0.74014369
97MP0002088_abnormal_embryonic_growth/wei0.73887796
98MP0003656_abnormal_erythrocyte_physiolo0.73396307
99MP0002086_abnormal_extraembryonic_tissu0.72714602
100MP0002177_abnormal_outer_ear0.72248720
101MP0000678_abnormal_parathyroid_gland0.72105718
102MP0003868_abnormal_feces_composition0.72034102
103MP0009379_abnormal_foot_pigmentation0.71284032
104MP0002080_prenatal_lethality0.70912065
105MP0006072_abnormal_retinal_apoptosis0.69798206
106MP0010030_abnormal_orbit_morphology0.69380053
107MP0005501_abnormal_skin_physiology0.68913890
108MP0001324_abnormal_eye_pigmentation0.68355188
109MP0003950_abnormal_plasma_membrane0.64475809
110MP0000427_abnormal_hair_cycle0.63600404
111MP0002932_abnormal_joint_morphology0.62605799
112MP0002116_abnormal_craniofacial_bone0.62263200
113MP0003861_abnormal_nervous_system0.61655771
114MP0008004_abnormal_stomach_pH0.61328699
115MP0000049_abnormal_middle_ear0.60494487
116MP0010386_abnormal_urinary_bladder0.60480868
117MP0002796_impaired_skin_barrier0.57836718
118MP0002089_abnormal_postnatal_growth/wei0.57756284
119MP0002168_other_aberrant_phenotype0.56857839
120MP0000432_abnormal_head_morphology0.56727204
121MP0003890_abnormal_embryonic-extraembry0.56404518
122MP0002233_abnormal_nose_morphology0.56182254
123MP0003941_abnormal_skin_development0.56028872
124MP0004270_analgesia0.55895937
125MP0005389_reproductive_system_phenotype0.55119443
126MP0001919_abnormal_reproductive_system0.54819839
127MP0003935_abnormal_craniofacial_develop0.54740886
128MP0001963_abnormal_hearing_physiology0.54463097
129MP0005384_cellular_phenotype0.52835602
130MP0005409_darkened_coat_color0.52133848
131MP0000631_abnormal_neuroendocrine_gland0.50578939
132MP0001502_abnormal_circadian_rhythm0.50038990
133MP0005187_abnormal_penis_morphology0.49710993
134MP0002295_abnormal_pulmonary_circulatio0.49492851
135MP0002735_abnormal_chemical_nociception0.49216678
136MP0003329_amyloid_beta_deposits0.49046099
137MP0000566_synostosis0.48745534
138MP0005075_abnormal_melanosome_morpholog0.48584548
139MP0005508_abnormal_skeleton_morphology0.48579668
140MP0005197_abnormal_uvea_morphology0.48385540
141MP0006138_congestive_heart_failure0.47125589
142MP0000313_abnormal_cell_death0.47089910
143MP0002127_abnormal_cardiovascular_syste0.46629275
144MP0004381_abnormal_hair_follicle0.46248571
145MP0002638_abnormal_pupillary_reflex0.44798642
146MP0002114_abnormal_axial_skeleton0.44594475
147MP0005174_abnormal_tail_pigmentation0.42550800
148MP0003959_abnormal_lean_body0.42091243
149MP0000383_abnormal_hair_follicle0.41324803
150MP0000465_gastrointestinal_hemorrhage0.40931377
151MP0002090_abnormal_vision0.39678333
152MP0002873_normal_phenotype0.37538104
153MP0005319_abnormal_enzyme/_coenzyme0.37432469
154MP0000428_abnormal_craniofacial_morphol0.37061542
155MP0002169_no_abnormal_phenotype0.36858313
156MP0000377_abnormal_hair_follicle0.36133148
157MP0005023_abnormal_wound_healing0.36122040
158MP0004043_abnormal_pH_regulation0.35709088

Predicted human phenotypes

RankGene SetZ-score
1Male infertility (HP:0003251)7.86575793
2Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)6.28476504
3Abdominal situs inversus (HP:0003363)5.24828129
4Abnormality of abdominal situs (HP:0011620)5.24828129
5Birth length less than 3rd percentile (HP:0003561)5.08789832
6Osteomalacia (HP:0002749)4.98858104
7Papillary thyroid carcinoma (HP:0002895)4.88155416
8Breast hypoplasia (HP:0003187)4.86324211
9Impulsivity (HP:0100710)4.85787326
10Hypophosphatemic rickets (HP:0004912)4.72587347
11Chromsome breakage (HP:0040012)4.60264871
12Facial hemangioma (HP:0000329)4.51589122
13Abnormality of the labia minora (HP:0012880)4.44542637
14Shawl scrotum (HP:0000049)4.40617687
15Adrenal hypoplasia (HP:0000835)4.29985081
16Chromosomal breakage induced by crosslinking agents (HP:0003221)4.24410327
17Patellar aplasia (HP:0006443)4.23624090
18Septo-optic dysplasia (HP:0100842)4.09913370
19Flat capital femoral epiphysis (HP:0003370)3.92970605
20Aplasia/Hypoplasia of the patella (HP:0006498)3.91919079
21Azoospermia (HP:0000027)3.71849743
22Secondary amenorrhea (HP:0000869)3.62881752
23Capillary hemangiomas (HP:0005306)3.55745918
24Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.54611363
25Premature ovarian failure (HP:0008209)3.53717405
26Apathy (HP:0000741)3.48778553
27Median cleft lip (HP:0000161)3.45478645
28Diminished motivation (HP:0000745)3.35539189
29Hypokinesia (HP:0002375)3.32809285
30Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.30061101
31Abnormality of lateral ventricle (HP:0030047)3.29687302
32Aplasia/Hypoplasia of the macula (HP:0008059)3.25455704
33Absent septum pellucidum (HP:0001331)3.17370104
34Cortical dysplasia (HP:0002539)3.15968730
35Conjunctival telangiectasia (HP:0000524)3.13455812
36Breast aplasia (HP:0100783)3.09645729
37Gonadotropin excess (HP:0000837)3.08974046
38Aplasia/Hypoplasia of the breasts (HP:0010311)3.06735785
39Abnormality of chromosome segregation (HP:0002916)3.00775971
40Abnormal spermatogenesis (HP:0008669)3.00239825
41Abnormality of the fingertips (HP:0001211)2.99023896
42Aplasia/Hypoplasia affecting the retina (HP:0008061)2.97365716
43Acute myeloid leukemia (HP:0004808)2.96386257
44Infertility (HP:0000789)2.96240578
45Arterial tortuosity (HP:0005116)2.92709713
46Abnormality of chromosome stability (HP:0003220)2.86391507
47Pulmonary fibrosis (HP:0002206)2.82625646
48Short tibia (HP:0005736)2.79881014
49Sandal gap (HP:0001852)2.79669106
50Oligodactyly (hands) (HP:0001180)2.78996570
51Supernumerary spleens (HP:0009799)2.75802949
52Truncal obesity (HP:0001956)2.75731669
53Spinal cord compression (HP:0002176)2.74482203
54Hypergonadotropic hypogonadism (HP:0000815)2.73611237
55Generalized aminoaciduria (HP:0002909)2.69665120
56Overlapping toe (HP:0001845)2.68639131
57Lower limb hyperreflexia (HP:0002395)2.67123991
58Aplasia/Hypoplasia of the uvula (HP:0010293)2.63621737
59Oligodactyly (HP:0012165)2.59812213
60Spondylolisthesis (HP:0003302)2.59389740
61Abnormality of the septum pellucidum (HP:0007375)2.58404072
62Aplasia of the musculature (HP:0100854)2.57563968
63Metaphyseal irregularity (HP:0003025)2.57292239
64Aplasia/Hypoplasia of the sternum (HP:0006714)2.55262820
65Thyroid carcinoma (HP:0002890)2.55010217
66Abnormality of the preputium (HP:0100587)2.54412003
67Rib fusion (HP:0000902)2.52310362
68Carpal bone hypoplasia (HP:0001498)2.52240256
69Lip pit (HP:0100267)2.52228990
70Striae distensae (HP:0001065)2.50749355
71Vascular tortuosity (HP:0004948)2.49913622
72Urethral obstruction (HP:0000796)2.49298872
73Chronic bronchitis (HP:0004469)2.48425144
74Abnormality of the vasculature of the conjunctiva (HP:0008054)2.47155292
75Aplasia/Hypoplasia of the tibia (HP:0005772)2.46592522
76Enlarged penis (HP:0000040)2.45048683
77Absent radius (HP:0003974)2.44781963
78Meckel diverticulum (HP:0002245)2.44732479
79Muscle stiffness (HP:0003552)2.43639613
80Skin pits (HP:0100276)2.41344274
81Bundle branch block (HP:0011710)2.39800536
82Proximal tubulopathy (HP:0000114)2.38539433
83Posterior subcapsular cataract (HP:0007787)2.37261220
84Congenital sensorineural hearing impairment (HP:0008527)2.37122633
85Insulin-resistant diabetes mellitus (HP:0000831)2.36814621
86Loss of speech (HP:0002371)2.35923705
87Absent forearm bone (HP:0003953)2.35315709
88Aplasia involving forearm bones (HP:0009822)2.35315709
89Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.32636979
90Aplasia/Hypoplasia involving the musculature (HP:0001460)2.31519445
91Fair hair (HP:0002286)2.31455041
92Abnormal ciliary motility (HP:0012262)2.31412243
93Cystic hygroma (HP:0000476)2.30845776
94Myokymia (HP:0002411)2.30431010
95Abnormality of the ileum (HP:0001549)2.29436588
96Prostate neoplasm (HP:0100787)2.29030517
97Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.28973048
98Duodenal stenosis (HP:0100867)2.26386708
99Small intestinal stenosis (HP:0012848)2.26386708
100Sparse lateral eyebrow (HP:0005338)2.24843829
101Rhabdomyosarcoma (HP:0002859)2.24093569
102Dysdiadochokinesis (HP:0002075)2.22591433
103Myelodysplasia (HP:0002863)2.20295910
104Ectopic kidney (HP:0000086)2.18599005
105Primary amenorrhea (HP:0000786)2.17720750
106Wrist flexion contracture (HP:0001239)2.17411599
107Aplasia/Hypoplasia of the tongue (HP:0010295)2.16729697
108Abnormality of the proximal phalanges of the hand (HP:0009834)2.16357674
109Intrahepatic cholestasis (HP:0001406)2.13304862
110Maternal diabetes (HP:0009800)2.12764259
111Deep venous thrombosis (HP:0002625)2.09907366
112Anhidrosis (HP:0000970)2.09763104
113Short thumb (HP:0009778)2.08987211
114Abnormality of the epiphysis of the femoral head (HP:0010574)2.08073206
115Nausea (HP:0002018)2.07147598
116Increased circulating renin level (HP:0000848)2.06837764
117Pancreatic fibrosis (HP:0100732)2.06508214
118Abnormality of the fovea (HP:0000493)2.05976882
119Aplasia/Hypoplasia of the fovea (HP:0008060)2.04306413
120Hypoplasia of the fovea (HP:0007750)2.04306413
121Sloping forehead (HP:0000340)2.03703394
122Hypoplastic iliac wings (HP:0002866)2.02772704
123Abnormal auditory evoked potentials (HP:0006958)2.02763195
124Abnormality of the phalanges of the hallux (HP:0010057)2.02097976
125Stillbirth (HP:0003826)2.01922897
126Fibular aplasia (HP:0002990)2.00986962
127Oral leukoplakia (HP:0002745)2.00417667
128Abnormality of calcium-phosphate metabolism (HP:0100530)1.99337781
129Subcapsular cataract (HP:0000523)1.98359491
130Type 2 muscle fiber atrophy (HP:0003554)1.98234785
131Neoplasm of the oral cavity (HP:0100649)1.96205901
132Cafe-au-lait spot (HP:0000957)1.94893830
133Bile duct proliferation (HP:0001408)1.94717584
134Abnormal biliary tract physiology (HP:0012439)1.94717584
135Abnormality of the anterior chamber (HP:0000593)1.93929869
136Hypercortisolism (HP:0001578)1.91966203
137Heterotopia (HP:0002282)1.90253190
138Clubbing of toes (HP:0100760)1.90188863
139Fetal akinesia sequence (HP:0001989)1.89398176
140Abnormality of the femoral head (HP:0003368)1.89386860
141Muscle fiber atrophy (HP:0100295)1.88975089
142Tetany (HP:0001281)1.88216152
143Rickets (HP:0002748)1.88002351
144Nephroblastoma (Wilms tumor) (HP:0002667)1.87550953
145Abnormality of cochlea (HP:0000375)1.87431269
146Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.87257974
147Abnormality of femoral epiphyses (HP:0006499)1.87257974
148Anterior segment dysgenesis (HP:0007700)1.84771149
149Aplastic anemia (HP:0001915)1.82956534
150Abnormal respiratory motile cilium physiology (HP:0012261)1.82198198
151Optic nerve hypoplasia (HP:0000609)1.81866914
152Nonprogressive disorder (HP:0003680)1.81811937
153Midline defect of the nose (HP:0004122)1.81283667
154Abnormality of aromatic amino acid family metabolism (HP:0004338)1.81110401
155Cranial hyperostosis (HP:0004437)1.79250362
156Abnormality of monocarboxylic acid metabolism (HP:0010996)1.78994176
157Abnormal lung lobation (HP:0002101)1.78929570
158Amniotic constriction ring (HP:0009775)1.77745345
159Abnormality of placental membranes (HP:0011409)1.77745345
160Abnormality of the labia (HP:0000058)1.77515400
161Hyperglycemia (HP:0003074)1.76931140
162Abnormal gallbladder physiology (HP:0012438)1.76398807
163Cholecystitis (HP:0001082)1.76398807
164Malnutrition (HP:0004395)1.75626791
165Hydroureter (HP:0000072)1.74752204
166Abnormality of the duodenum (HP:0002246)1.74745969
167Abnormality of the carotid arteries (HP:0005344)1.74358575
168Sensory axonal neuropathy (HP:0003390)1.73856277
169Hypohidrosis (HP:0000966)1.71185179
170Hip contracture (HP:0003273)1.69720315
171Broad alveolar ridges (HP:0000187)1.68933803
172Microglossia (HP:0000171)1.68561612
173Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.68163537

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KSR23.63297271
2MAP3K63.58330293
3MOS3.56398526
4LATS23.55789509
5MUSK3.53623219
6PLK43.49644254
7LATS13.40279434
8TAOK33.38522002
9EEF2K3.16552224
10NEK63.12981366
11TTK3.10626870
12MAP3K92.99440703
13ERBB42.99310864
14BRAF2.90960915
15BMPR22.75236169
16RAF12.53561327
17TAOK12.53371400
18MAP3K132.49527699
19STK38L2.49516853
20CDC72.36889340
21ARAF2.29458238
22MAPKAPK32.25857476
23MET2.15120046
24KSR11.75130925
25PAK61.74951123
26MST41.72515804
27TRIM281.63060145
28NEK21.63048035
29CDK81.62188407
30MELK1.54255090
31TNIK1.49652716
32CDK91.47747013
33STK31.43098399
34DYRK21.34313983
35CHEK21.33201134
36PLK11.29905232
37STK101.20149090
38EIF2AK31.14472711
39MAPKAPK51.08022919
40MAPK131.06774286
41BUB11.04973020
42PTK21.02050126
43TNK21.01773557
44PRKD31.01748173
45PIM10.97617300
46ACVR1B0.93759470
47MAP3K80.90251937
48MAP3K40.87351017
49MARK30.84836849
50PRKD20.83481545
51TYRO30.80407620
52RPS6KB20.79881995
53AURKB0.78758420
54BMPR1B0.75686877
55TRPM70.75519630
56ABL20.75064259
57ZAK0.71562355
58MARK20.71403378
59PRKAA20.70901193
60STK380.68980644
61WNK10.66832685
62NLK0.65741407
63DMPK0.65610405
64AURKA0.65130831
65CDK190.64545382
66CSNK1G10.64533481
67TIE10.64149020
68PRKG10.61158217
69TGFBR10.61028469
70PRKAA10.58519809
71PLK30.57947958
72CSNK1D0.56558960
73RET0.54219725
74PKN10.50640172
75NTRK30.49691863
76STK390.49476109
77PRKCZ0.46363622
78CHEK10.45693759
79MTOR0.45085066
80CDK70.43924268
81MAP2K70.43503342
82PINK10.43493277
83CSNK1G20.42153637
84MAPK110.41135107
85LRRK20.40575138
86PDK10.40443944
87MAP3K50.40114044
88CDK40.39310249
89CSNK1E0.39043673
90ATM0.38885033
91MAP2K40.38507370
92CSNK1G30.38489250
93CDK30.35671212
94SGK20.35076268
95CDK120.34704995
96NUAK10.34668166
97BRSK10.34330894
98CDK50.32596097
99EPHA30.31194138
100NTRK20.31010829
101STK240.30667520
102NEK90.29241650
103MAP3K10.28932477
104PRKACB0.28883699
105CSF1R0.28659669
106CDK10.27272542
107WEE10.27208046
108PRKACA0.26985708
109CDK20.26717919
110PAK10.26517597
111MAP2K10.26386084
112CAMK2A0.25303115
113EIF2AK10.24995596
114LMTK20.24308886
115NEK10.24079040
116CHUK0.22310048
117ILK0.22304227
118TLK10.22021494
119VRK10.21904737
120PDPK10.21887155
121GSK3B0.21474641
122CSNK1A1L0.21131899
123PAK30.20078221
124SGK2230.19952192
125SGK4940.19952192
126DYRK30.19035774
127PRKCI0.18714711
128ABL10.18513203
129FGR0.18384846
130HIPK20.18367920
131SRPK10.18304838
132ATR0.18281035
133MAPK10.18142951
134AKT20.18029531
135BRSK20.17246498
136MAPK100.16726383
137RPS6KA40.16455624
138CAMK1D0.15504446
139JAK20.13067507
140CDK150.12635632
141CAMK1G0.12432552
142STK40.11433627

Predicted pathways (KEGG)

RankGene SetZ-score
1Cell cycle_Homo sapiens_hsa041104.46232181
2RNA degradation_Homo sapiens_hsa030183.84235231
3Ovarian steroidogenesis_Homo sapiens_hsa049133.73315884
4Basal transcription factors_Homo sapiens_hsa030223.42456990
5Vitamin B6 metabolism_Homo sapiens_hsa007503.27037037
6Circadian rhythm_Homo sapiens_hsa047103.08389281
7Caffeine metabolism_Homo sapiens_hsa002322.93558803
8Oocyte meiosis_Homo sapiens_hsa041142.59736461
9Progesterone-mediated oocyte maturation_Homo sapiens_hsa049142.43909987
10alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.30542814
11Linoleic acid metabolism_Homo sapiens_hsa005912.29593013
12Pancreatic cancer_Homo sapiens_hsa052122.26602551
13Homologous recombination_Homo sapiens_hsa034402.21407009
14Fanconi anemia pathway_Homo sapiens_hsa034602.13409214
15Olfactory transduction_Homo sapiens_hsa047402.08369538
16RNA polymerase_Homo sapiens_hsa030202.06388166
17TGF-beta signaling pathway_Homo sapiens_hsa043502.05314876
18Ether lipid metabolism_Homo sapiens_hsa005652.04204649
19Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.02215252
20p53 signaling pathway_Homo sapiens_hsa041151.99685125
21Gap junction_Homo sapiens_hsa045401.95386451
22RNA transport_Homo sapiens_hsa030131.91830705
23Base excision repair_Homo sapiens_hsa034101.80647323
24DNA replication_Homo sapiens_hsa030301.69692799
25Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.59105749
26Phototransduction_Homo sapiens_hsa047441.54998954
27Mismatch repair_Homo sapiens_hsa034301.54792006
28GnRH signaling pathway_Homo sapiens_hsa049121.53386382
29SNARE interactions in vesicular transport_Homo sapiens_hsa041301.46932241
30Colorectal cancer_Homo sapiens_hsa052101.45215978
31Non-homologous end-joining_Homo sapiens_hsa034501.44356082
32Nucleotide excision repair_Homo sapiens_hsa034201.43086010
33Choline metabolism in cancer_Homo sapiens_hsa052311.41284325
34MicroRNAs in cancer_Homo sapiens_hsa052061.40312462
35Prolactin signaling pathway_Homo sapiens_hsa049171.38549588
36Dorso-ventral axis formation_Homo sapiens_hsa043201.38532650
37Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.33864001
38Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.25241932
39mRNA surveillance pathway_Homo sapiens_hsa030151.21504420
40Cysteine and methionine metabolism_Homo sapiens_hsa002701.14441259
41ABC transporters_Homo sapiens_hsa020101.10348305
42VEGF signaling pathway_Homo sapiens_hsa043701.09324650
43Renal cell carcinoma_Homo sapiens_hsa052111.07475315
44Morphine addiction_Homo sapiens_hsa050321.04472325
45Hippo signaling pathway_Homo sapiens_hsa043901.00641062
46Phosphatidylinositol signaling system_Homo sapiens_hsa040700.97587528
47Adherens junction_Homo sapiens_hsa045200.97582927
48Glycerophospholipid metabolism_Homo sapiens_hsa005640.94492627
49Fatty acid elongation_Homo sapiens_hsa000620.92070435
50GABAergic synapse_Homo sapiens_hsa047270.90389907
51FoxO signaling pathway_Homo sapiens_hsa040680.88592149
52Thyroid cancer_Homo sapiens_hsa052160.87293677
53Endometrial cancer_Homo sapiens_hsa052130.86882259
54Bile secretion_Homo sapiens_hsa049760.86283011
55Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.85821513
56Long-term depression_Homo sapiens_hsa047300.85793359
57Folate biosynthesis_Homo sapiens_hsa007900.82619359
58Notch signaling pathway_Homo sapiens_hsa043300.82333372
59Pyrimidine metabolism_Homo sapiens_hsa002400.81079708
60Small cell lung cancer_Homo sapiens_hsa052220.75802550
61Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.74674451
62Nicotine addiction_Homo sapiens_hsa050330.74507535
63Taste transduction_Homo sapiens_hsa047420.70641729
64Thyroid hormone signaling pathway_Homo sapiens_hsa049190.69804123
65Phospholipase D signaling pathway_Homo sapiens_hsa040720.69761035
66Synaptic vesicle cycle_Homo sapiens_hsa047210.68916055
67Ras signaling pathway_Homo sapiens_hsa040140.67698498
68mTOR signaling pathway_Homo sapiens_hsa041500.66940422
69Bladder cancer_Homo sapiens_hsa052190.66904706
70Chronic myeloid leukemia_Homo sapiens_hsa052200.66883332
71Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.66208671
72Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.64988456
73Hepatitis B_Homo sapiens_hsa051610.64132605
74Non-small cell lung cancer_Homo sapiens_hsa052230.61921932
75Purine metabolism_Homo sapiens_hsa002300.61168673
76Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.60918333
77Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.57713420
78Prostate cancer_Homo sapiens_hsa052150.57127200
79Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.55348782
80Arachidonic acid metabolism_Homo sapiens_hsa005900.55140488
81Longevity regulating pathway - mammal_Homo sapiens_hsa042110.53792750
82Herpes simplex infection_Homo sapiens_hsa051680.52410619
83Estrogen signaling pathway_Homo sapiens_hsa049150.52195642
84Aldosterone synthesis and secretion_Homo sapiens_hsa049250.49324125
85HTLV-I infection_Homo sapiens_hsa051660.47700261
86ErbB signaling pathway_Homo sapiens_hsa040120.47447235
87Other glycan degradation_Homo sapiens_hsa005110.45779735
88MAPK signaling pathway_Homo sapiens_hsa040100.43935003
89Glycosaminoglycan degradation_Homo sapiens_hsa005310.41211098
90Platelet activation_Homo sapiens_hsa046110.39888238
91One carbon pool by folate_Homo sapiens_hsa006700.39052682
92Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.37856550
93Transcriptional misregulation in cancer_Homo sapiens_hsa052020.37296952
94Wnt signaling pathway_Homo sapiens_hsa043100.36752070
95Inositol phosphate metabolism_Homo sapiens_hsa005620.36434571
96Chemokine signaling pathway_Homo sapiens_hsa040620.36388499
97Glioma_Homo sapiens_hsa052140.34943181
98Serotonergic synapse_Homo sapiens_hsa047260.33838624
99Phagosome_Homo sapiens_hsa041450.33581058
100Epstein-Barr virus infection_Homo sapiens_hsa051690.33514952
101Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.33324097
102cGMP-PKG signaling pathway_Homo sapiens_hsa040220.33302037
103Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.33137676
104Melanoma_Homo sapiens_hsa052180.32596964
105Hedgehog signaling pathway_Homo sapiens_hsa043400.31771136
106Pathways in cancer_Homo sapiens_hsa052000.30476405
107Cholinergic synapse_Homo sapiens_hsa047250.30167372
108Biosynthesis of amino acids_Homo sapiens_hsa012300.29811031
109Circadian entrainment_Homo sapiens_hsa047130.29744873
110Regulation of actin cytoskeleton_Homo sapiens_hsa048100.29345886
111Sphingolipid signaling pathway_Homo sapiens_hsa040710.29259933
112Oxytocin signaling pathway_Homo sapiens_hsa049210.28821152
113Arginine and proline metabolism_Homo sapiens_hsa003300.28612904
114Vascular smooth muscle contraction_Homo sapiens_hsa042700.27697827
115AMPK signaling pathway_Homo sapiens_hsa041520.27435876
116Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.24698570
117Viral carcinogenesis_Homo sapiens_hsa052030.23507858
118Tight junction_Homo sapiens_hsa045300.23308721
119Glutamatergic synapse_Homo sapiens_hsa047240.22555066
120Shigellosis_Homo sapiens_hsa051310.22219537
121Lysine degradation_Homo sapiens_hsa003100.21150501
122Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.20707543
123Rap1 signaling pathway_Homo sapiens_hsa040150.19455499
124Jak-STAT signaling pathway_Homo sapiens_hsa046300.18967716
125TNF signaling pathway_Homo sapiens_hsa046680.18741611
126Amoebiasis_Homo sapiens_hsa051460.18594461
127cAMP signaling pathway_Homo sapiens_hsa040240.18581891
128Collecting duct acid secretion_Homo sapiens_hsa049660.17984063
129Vitamin digestion and absorption_Homo sapiens_hsa049770.17918116
130Calcium signaling pathway_Homo sapiens_hsa040200.17400180
131Regulation of autophagy_Homo sapiens_hsa041400.17226178
132Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.14732605
133Spliceosome_Homo sapiens_hsa030400.13761908
134Arginine biosynthesis_Homo sapiens_hsa002200.13727209
135Long-term potentiation_Homo sapiens_hsa047200.13650456
136Sphingolipid metabolism_Homo sapiens_hsa006000.13517399
137B cell receptor signaling pathway_Homo sapiens_hsa046620.12121382
138PI3K-Akt signaling pathway_Homo sapiens_hsa041510.10522454

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