ACD

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that is involved in telomere function. This protein is one of six core proteins in the telosome/shelterin telomeric complex, which functions to maintain telomere length and to protect telomere ends. Through its interaction with other components, this protein plays a key role in the assembly and stabilization of this complex, and it mediates the access of telomerase to the telomere. Multiple transcript variants encoding different isoforms have been found for this gene. This gene, which is also referred to as TPP1, is distinct from the unrelated TPP1 gene on chromosome 11, which encodes tripeptidyl-peptidase I. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.63614472
2telomere maintenance via semi-conservative replication (GO:0032201)4.67779283
3DNA strand elongation involved in DNA replication (GO:0006271)4.65997059
4DNA strand elongation (GO:0022616)4.46262260
5ribosomal small subunit assembly (GO:0000028)4.26390582
6proteasome assembly (GO:0043248)4.24866336
7telomere maintenance via recombination (GO:0000722)4.19185409
8DNA replication initiation (GO:0006270)4.15560510
9regulation of mitochondrial translation (GO:0070129)4.02221742
10deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.88374736
11negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.84016847
12establishment of viral latency (GO:0019043)3.83976312
13tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.77832328
14RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.77832328
15negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.76524767
16mitotic recombination (GO:0006312)3.74550384
17telomere maintenance via telomere lengthening (GO:0010833)3.74469134
18iron-sulfur cluster assembly (GO:0016226)3.73614012
19metallo-sulfur cluster assembly (GO:0031163)3.73614012
20protein maturation by protein folding (GO:0022417)3.72840760
21negative regulation of DNA-templated transcription, elongation (GO:0032785)3.70843469
22establishment of integrated proviral latency (GO:0075713)3.70581124
23anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.68861184
24translational elongation (GO:0006414)3.68014421
25purine deoxyribonucleotide catabolic process (GO:0009155)3.67600991
26regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.61708308
27deoxyribonucleotide catabolic process (GO:0009264)3.59513046
28DNA replication checkpoint (GO:0000076)3.58826869
29nucleotide-excision repair, DNA gap filling (GO:0006297)3.57258776
30positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.56629368
31formation of translation preinitiation complex (GO:0001731)3.55003252
32guanosine-containing compound biosynthetic process (GO:1901070)3.53471352
33protein deneddylation (GO:0000338)3.50848283
34pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.49168884
35GTP biosynthetic process (GO:0006183)3.47516666
36mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.47413615
37exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.45798885
38UTP biosynthetic process (GO:0006228)3.42604655
39viral mRNA export from host cell nucleus (GO:0046784)3.42491096
40negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.40558501
41negative regulation of ligase activity (GO:0051352)3.40558501
42pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.40337293
43deoxyribose phosphate catabolic process (GO:0046386)3.37668770
44nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.36566008
45transcription-coupled nucleotide-excision repair (GO:0006283)3.36278456
46mitotic metaphase plate congression (GO:0007080)3.36204467
47viral life cycle (GO:0019058)3.33870736
487-methylguanosine mRNA capping (GO:0006370)3.33851131
49cullin deneddylation (GO:0010388)3.33629510
50energy coupled proton transport, down electrochemical gradient (GO:0015985)3.33307647
51ATP synthesis coupled proton transport (GO:0015986)3.33307647
52protein insertion into membrane (GO:0051205)3.32707928
53histone H2A acetylation (GO:0043968)3.31936825
54establishment of protein localization to mitochondrial membrane (GO:0090151)3.31644484
55pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.22886140
567-methylguanosine RNA capping (GO:0009452)3.22786634
57RNA capping (GO:0036260)3.22786634
58protein targeting to ER (GO:0045047)3.21545022
59peptidyl-arginine omega-N-methylation (GO:0035247)3.21411298
60DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.21039764
61L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.20505838
62maturation of SSU-rRNA (GO:0030490)3.19995238
63CTP biosynthetic process (GO:0006241)3.19273934
64CTP metabolic process (GO:0046036)3.19273934
65positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.17900000
66pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.17295410
67base-excision repair (GO:0006284)3.14954263
68GDP-mannose metabolic process (GO:0019673)3.14760647
69intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.14711893
70signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.14711893
71signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.14298040
72signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.14298040
73signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.14298040
74establishment of mitochondrion localization (GO:0051654)3.13427990
75protein localization to endoplasmic reticulum (GO:0070972)3.11410115
76cellular protein complex disassembly (GO:0043624)3.11343224
77mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.11115359
78mitochondrial respiratory chain complex I assembly (GO:0032981)3.11115359
79NADH dehydrogenase complex assembly (GO:0010257)3.11115359
80nucleobase biosynthetic process (GO:0046112)3.10913421
81nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.10279693
82spliceosomal snRNP assembly (GO:0000387)3.10237368
83mannosylation (GO:0097502)3.10079372
84termination of RNA polymerase III transcription (GO:0006386)3.08277208
85transcription elongation from RNA polymerase III promoter (GO:0006385)3.08277208
86purine nucleobase biosynthetic process (GO:0009113)3.07294735
87ribosomal large subunit biogenesis (GO:0042273)3.05831184
88protein complex disassembly (GO:0043241)3.05634515
89antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.05479060
90positive regulation of ligase activity (GO:0051351)3.04510116
91GMP metabolic process (GO:0046037)3.04297482
92deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.04256851
93G1/S transition of mitotic cell cycle (GO:0000082)3.03955191
94cell cycle G1/S phase transition (GO:0044843)3.03955191
95CENP-A containing nucleosome assembly (GO:0034080)3.03315894
96establishment of protein localization to endoplasmic reticulum (GO:0072599)3.03231590
97signal transduction involved in DNA damage checkpoint (GO:0072422)3.03136646
98signal transduction involved in DNA integrity checkpoint (GO:0072401)3.03136646
99signal transduction involved in cell cycle checkpoint (GO:0072395)3.03024568
100establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.02979191
101mitochondrion transport along microtubule (GO:0047497)3.02979191
102peptidyl-histidine modification (GO:0018202)3.02661337
103protein targeting to mitochondrion (GO:0006626)3.02298625
104base-excision repair, AP site formation (GO:0006285)3.02061145
105intra-S DNA damage checkpoint (GO:0031573)3.02019484
106cellular component biogenesis (GO:0044085)3.01909746
107protein complex biogenesis (GO:0070271)3.01476239
108pentose metabolic process (GO:0019321)3.01014650
109ribosome biogenesis (GO:0042254)3.00907728
1102-deoxyribonucleotide metabolic process (GO:0009394)3.00268914
111pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.98203267
112L-serine metabolic process (GO:0006563)2.98144673
113macromolecular complex disassembly (GO:0032984)2.96897544
114ubiquinone biosynthetic process (GO:0006744)2.96237900
115UTP metabolic process (GO:0046051)2.95964391
116establishment of protein localization to mitochondrion (GO:0072655)2.95350080
117regulation of cellular amino acid metabolic process (GO:0006521)2.94168713
118maturation of 5.8S rRNA (GO:0000460)2.94045396
119negative regulation of B cell apoptotic process (GO:0002903)2.93934533
120DNA unwinding involved in DNA replication (GO:0006268)2.92882247
121pyrimidine nucleotide catabolic process (GO:0006244)2.91697058
122translational initiation (GO:0006413)2.91325105
123establishment of chromosome localization (GO:0051303)2.89634662
124metaphase plate congression (GO:0051310)2.89229810
125regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.88566058
126antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.87406825
127regulation of ubiquitin-protein transferase activity (GO:0051438)2.86712138
128spliceosomal complex assembly (GO:0000245)2.86631867
129pseudouridine synthesis (GO:0001522)2.84362320
130pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.84260966
131chromatin remodeling at centromere (GO:0031055)2.84124213
132respiratory chain complex IV assembly (GO:0008535)2.83375736
133mitochondrial respiratory chain complex assembly (GO:0033108)2.80134690
134deoxyribonucleotide biosynthetic process (GO:0009263)2.79984032
135DNA damage response, detection of DNA damage (GO:0042769)2.79781971
136chaperone-mediated protein transport (GO:0072321)2.79668598
137deoxyribose phosphate metabolic process (GO:0019692)2.78601666
138* telomere organization (GO:0032200)2.78447910
139translation (GO:0006412)2.78419096
1402-deoxyribonucleotide biosynthetic process (GO:0009265)2.78040091
141deoxyribose phosphate biosynthetic process (GO:0046385)2.78040091
142rRNA modification (GO:0000154)2.77947178
143protein K11-linked ubiquitination (GO:0070979)2.77554317
144regulation of ligase activity (GO:0051340)2.76814495
145* telomere maintenance (GO:0000723)2.76169641
146inner mitochondrial membrane organization (GO:0007007)2.75629500
147viral transcription (GO:0019083)2.75428078
148ribonucleoprotein complex biogenesis (GO:0022613)2.75039309
149SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.74106282
150de novo protein folding (GO:0006458)2.73256083
151histone arginine methylation (GO:0034969)2.73180607
152DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.72470129
153maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.70807781
154transcription elongation from RNA polymerase II promoter (GO:0006368)2.70333764
155ribosomal small subunit biogenesis (GO:0042274)2.69758433
156rRNA processing (GO:0006364)2.69620961
157DNA replication-independent nucleosome organization (GO:0034724)2.69042918
158DNA replication-independent nucleosome assembly (GO:0006336)2.69042918
159attachment of spindle microtubules to kinetochore (GO:0008608)2.65712037
160translational termination (GO:0006415)2.65193931
161positive regulation of cell cycle arrest (GO:0071158)2.64729815
162cotranslational protein targeting to membrane (GO:0006613)2.64469200
163nucleotide-excision repair (GO:0006289)2.63953658
164mitotic nuclear envelope disassembly (GO:0007077)2.63462914

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.42062530
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.83351113
3NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.67886384
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.57818715
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.49611069
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.49437740
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.39641419
8GABP_17652178_ChIP-ChIP_JURKAT_Human3.16969676
9ETS1_20019798_ChIP-Seq_JURKAT_Human3.07003448
10HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.98716073
11MYC_18358816_ChIP-ChIP_MESCs_Mouse2.78545245
12E2F4_17652178_ChIP-ChIP_JURKAT_Human2.72621216
13ELF1_17652178_ChIP-ChIP_JURKAT_Human2.69756207
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.66718103
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.65135784
16MYC_19030024_ChIP-ChIP_MESCs_Mouse2.57925901
17VDR_23849224_ChIP-Seq_CD4+_Human2.46851712
18THAP11_20581084_ChIP-Seq_MESCs_Mouse2.35609898
19FOXM1_23109430_ChIP-Seq_U2OS_Human2.35181184
20SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.34371946
21TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.32910365
22HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.29784973
23MYC_19079543_ChIP-ChIP_MESCs_Mouse2.28425043
24MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.27987538
25XRN2_22483619_ChIP-Seq_HELA_Human2.25564347
26* GABP_19822575_ChIP-Seq_HepG2_Human2.22752073
27CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.19728760
28FOXP3_21729870_ChIP-Seq_TREG_Human2.17883105
29SRF_21415370_ChIP-Seq_HL-1_Mouse2.14502701
30* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.06808813
31CIITA_25753668_ChIP-Seq_RAJI_Human2.04408352
32E2F1_18555785_ChIP-Seq_MESCs_Mouse2.00942979
33MYC_22102868_ChIP-Seq_BL_Human2.00828364
34TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.96452610
35FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.96283462
36DCP1A_22483619_ChIP-Seq_HELA_Human1.95848002
37PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.95136860
38FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.92326489
39TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.89911864
40YY1_21170310_ChIP-Seq_MESCs_Mouse1.86897531
41HOXB4_20404135_ChIP-ChIP_EML_Mouse1.86658649
42PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.84674936
43TTF2_22483619_ChIP-Seq_HELA_Human1.83283852
44* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.80904881
45SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.78007238
46SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.73329519
47* E2F1_21310950_ChIP-Seq_MCF-7_Human1.69765838
48MYCN_18555785_ChIP-Seq_MESCs_Mouse1.68429155
49TET1_21451524_ChIP-Seq_MESCs_Mouse1.68381705
50YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.66451854
51CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.65755061
52TP63_19390658_ChIP-ChIP_HaCaT_Human1.64464365
53POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.61990963
54ERG_20887958_ChIP-Seq_HPC-7_Mouse1.57757703
55MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.57677132
56P68_20966046_ChIP-Seq_HELA_Human1.54316504
57ELF1_20517297_ChIP-Seq_JURKAT_Human1.52327808
58* LXR_22292898_ChIP-Seq_THP-1_Human1.51589315
59SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.51121013
60NANOG_18555785_ChIP-Seq_MESCs_Mouse1.49131125
61ELK1_19687146_ChIP-ChIP_HELA_Human1.48202217
62BCL6_27268052_Chip-Seq_Bcells_Human1.47109187
63IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.45961552
64ZFX_18555785_ChIP-Seq_MESCs_Mouse1.45487544
65SRY_22984422_ChIP-ChIP_TESTIS_Rat1.45110599
66* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.44547932
67CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.43590111
68MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.41993433
69NOTCH1_21737748_ChIP-Seq_TLL_Human1.41811702
70FOXP1_21924763_ChIP-Seq_HESCs_Human1.37943519
71ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.35051299
72SPI1_23547873_ChIP-Seq_NB4_Human1.31351771
73SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.29608243
74* KDM5A_27292631_Chip-Seq_BREAST_Human1.29183427
75GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.27025720
76BCOR_27268052_Chip-Seq_Bcells_Human1.26754370
77VDR_21846776_ChIP-Seq_THP-1_Human1.21175139
78BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.20986913
79RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.20462047
80KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.19801764
81* MAF_26560356_Chip-Seq_TH2_Human1.19631276
82PHF8_20622854_ChIP-Seq_HELA_Human1.19564880
83DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.16186097
84CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.16149909
85CTCF_26484167_Chip-Seq_Bcells_Mouse1.15683800
86* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.13565256
87YY1_22570637_ChIP-Seq_MALME-3M_Human1.13281369
88ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.13275113
89CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.12550295
90MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.11431796
91ZNF263_19887448_ChIP-Seq_K562_Human1.11295128
92E2F1_20622854_ChIP-Seq_HELA_Human1.10433663
93MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.09774169
94TFEB_21752829_ChIP-Seq_HELA_Human1.07821491
95E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.07371062
96RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.06816411
97SA1_27219007_Chip-Seq_ERYTHROID_Human1.06794648
98CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.05300382
99ELK3_25401928_ChIP-Seq_HUVEC_Human1.05104680
100CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.04798722
101KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.04425991
102KLF4_18555785_ChIP-Seq_MESCs_Mouse1.03091539
103AR_21909140_ChIP-Seq_LNCAP_Human1.02715996
104NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.02258057
105MYC_18940864_ChIP-ChIP_HL60_Human1.01803485
106CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.01026193
107IRF8_21731497_ChIP-ChIP_J774_Mouse1.00953965
108* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00586957
109ELK1_22589737_ChIP-Seq_MCF10A_Human1.00486030
110MAF_26560356_Chip-Seq_TH1_Human0.99853301
111CTCF_21964334_Chip-Seq_Bcells_Human0.99606061
112SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.99468549
113SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.99079464
114DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.97914742
115SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.96490719
116HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.94762517
117POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.94743484
118PADI4_21655091_ChIP-ChIP_MCF-7_Human0.91850141
119CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.90471464
120SCL_19346495_ChIP-Seq_HPC-7_Human0.89596685
121PU.1_20513432_ChIP-Seq_Bcells_Mouse0.85903937
122CTCF_18555785_ChIP-Seq_MESCs_Mouse0.85640537
123CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.84051488
124EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.83586448
125STAT4_19710469_ChIP-ChIP_TH1__Mouse0.83554386
126GATA1_22383799_ChIP-Seq_G1ME_Mouse0.83297623
127UTX_26944678_Chip-Seq_JUKART_Human0.82933897
128ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.82358883
129SOX2_18555785_ChIP-Seq_MESCs_Mouse0.82329917
130TBX5_21415370_ChIP-Seq_HL-1_Mouse0.82192490

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.05759564
2MP0010094_abnormal_chromosome_stability3.83237854
3MP0008058_abnormal_DNA_repair3.64987460
4MP0004957_abnormal_blastocyst_morpholog3.54850006
5MP0003077_abnormal_cell_cycle3.41918099
6MP0003111_abnormal_nucleus_morphology3.25233637
7MP0002396_abnormal_hematopoietic_system3.04310079
8MP0008007_abnormal_cellular_replicative2.85306631
9MP0003763_abnormal_thymus_physiology2.57457336
10MP0006292_abnormal_olfactory_placode2.44039073
11MP0008057_abnormal_DNA_replication2.41288085
12MP0009278_abnormal_bone_marrow2.30944940
13MP0006035_abnormal_mitochondrial_morpho2.19622439
14MP0008932_abnormal_embryonic_tissue2.06322993
15MP0004859_abnormal_synaptic_plasticity2.01583013
16MP0003786_premature_aging1.98791260
17MP0009333_abnormal_splenocyte_physiolog1.96235608
18MP0001348_abnormal_lacrimal_gland1.94629523
19MP0005075_abnormal_melanosome_morpholog1.93186055
20MP0002822_catalepsy1.92610138
21MP0005423_abnormal_somatic_nervous1.92299980
22MP0008877_abnormal_DNA_methylation1.89319033
23MP0002398_abnormal_bone_marrow1.85537321
24MP0001835_abnormal_antigen_presentation1.85111382
25MP0003880_abnormal_central_pattern1.84543112
26MP0001529_abnormal_vocalization1.83817607
27MP0005671_abnormal_response_to1.79186328
28MP0003718_maternal_effect1.72011897
29MP0001905_abnormal_dopamine_level1.70043804
30MP0000490_abnormal_crypts_of1.69609146
31MP0003123_paternal_imprinting1.63224338
32MP0000350_abnormal_cell_proliferation1.58043290
33MP0000689_abnormal_spleen_morphology1.54753160
34MP0002736_abnormal_nociception_after1.52390350
35MP0002653_abnormal_ependyma_morphology1.51782383
36MP0003806_abnormal_nucleotide_metabolis1.51695391
37MP0001968_abnormal_touch/_nociception1.51463159
38MP0002019_abnormal_tumor_incidence1.50236416
39MP0002132_abnormal_respiratory_system1.47934648
40MP0002722_abnormal_immune_system1.46550376
41MP0000313_abnormal_cell_death1.46351821
42MP0001730_embryonic_growth_arrest1.45433796
43MP0000703_abnormal_thymus_morphology1.44856214
44MP0004808_abnormal_hematopoietic_stem1.43830926
45MP0003121_genomic_imprinting1.43773128
46MP0005397_hematopoietic_system_phenotyp1.39149151
47MP0001545_abnormal_hematopoietic_system1.39149151
48MP0002429_abnormal_blood_cell1.38781063
49MP0000372_irregular_coat_pigmentation1.38212258
50MP0004147_increased_porphyrin_level1.35662956
51MP0005174_abnormal_tail_pigmentation1.32706984
52MP0000716_abnormal_immune_system1.32641791
53MP0000465_gastrointestinal_hemorrhage1.31586602
54MP0001346_abnormal_lacrimal_gland1.29389591
55MP0002420_abnormal_adaptive_immunity1.28626415
56MP0003646_muscle_fatigue1.28375878
57MP0003943_abnormal_hepatobiliary_system1.27723033
58MP0001819_abnormal_immune_cell1.25840702
59MP0001800_abnormal_humoral_immune1.24549085
60MP0005377_hearing/vestibular/ear_phenot1.24064857
61MP0003878_abnormal_ear_physiology1.24064857
62MP0000678_abnormal_parathyroid_gland1.22380063
63MP0005464_abnormal_platelet_physiology1.20142302
64MP0009785_altered_susceptibility_to1.19813194
65MP0005646_abnormal_pituitary_gland1.18938428
66MP0002452_abnormal_antigen_presenting1.15791648
67MP0006276_abnormal_autonomic_nervous1.15111377
68MP0010030_abnormal_orbit_morphology1.14251185
69MP0001119_abnormal_female_reproductive1.12271901
70MP0008789_abnormal_olfactory_epithelium1.11908109
71MP0000049_abnormal_middle_ear1.10756705
72MP0005058_abnormal_lysosome_morphology1.09872933
73MP0002723_abnormal_immune_serum1.08484937
74* MP0002095_abnormal_skin_pigmentation1.07836559
75MP0003122_maternal_imprinting1.07650523
76MP0000685_abnormal_immune_system1.06287450
77MP0002080_prenatal_lethality1.05299653
78MP0001697_abnormal_embryo_size1.05155591
79MP0005000_abnormal_immune_tolerance1.04341037
80MP0004142_abnormal_muscle_tone1.03967324
81MP0002405_respiratory_system_inflammati1.03316130
82MP0006054_spinal_hemorrhage1.02732820
83MP0000778_abnormal_nervous_system1.01655357
84MP0003656_abnormal_erythrocyte_physiolo1.01255474
85MP0008260_abnormal_autophagy1.01030775
86MP0000681_abnormal_thyroid_gland0.98668330
87MP0001188_hyperpigmentation0.98568552
88MP0001293_anophthalmia0.97575440
89MP0006036_abnormal_mitochondrial_physio0.97500034
90MP0003787_abnormal_imprinting0.97469535
91MP0002210_abnormal_sex_determination0.97291940
92MP0005025_abnormal_response_to0.96887908
93MP0003436_decreased_susceptibility_to0.95936756
94MP0002272_abnormal_nervous_system0.94828318
95MP0008995_early_reproductive_senescence0.94148671
96MP0005645_abnormal_hypothalamus_physiol0.93744157
97MP0002163_abnormal_gland_morphology0.93522112
98MP0005380_embryogenesis_phenotype0.92661831
99MP0001672_abnormal_embryogenesis/_devel0.92661831
100MP0000566_synostosis0.91180069
101MP0002148_abnormal_hypersensitivity_rea0.90332270
102MP0002160_abnormal_reproductive_system0.89490652
103MP0003186_abnormal_redox_activity0.87986012
104MP0000358_abnormal_cell_content/0.87721957
105MP0000631_abnormal_neuroendocrine_gland0.87248895
106MP0005389_reproductive_system_phenotype0.85288436
107MP0002733_abnormal_thermal_nociception0.84336436
108MP0002127_abnormal_cardiovascular_syste0.84100167
109MP0003635_abnormal_synaptic_transmissio0.84080455
110MP0001986_abnormal_taste_sensitivity0.83695783
111MP0004811_abnormal_neuron_physiology0.83668751
112MP0003984_embryonic_growth_retardation0.82781021
113MP0002249_abnormal_larynx_morphology0.82498109
114MP0005394_taste/olfaction_phenotype0.82218616
115MP0005499_abnormal_olfactory_system0.82218616
116MP0010352_gastrointestinal_tract_polyps0.82053148
117MP0002572_abnormal_emotion/affect_behav0.82024733
118MP0000858_altered_metastatic_potential0.81897019
119MP0002088_abnormal_embryonic_growth/wei0.80462230
120MP0002085_abnormal_embryonic_tissue0.79892887
121MP0001929_abnormal_gametogenesis0.78986661
122MP0001919_abnormal_reproductive_system0.78744306
123MP0002938_white_spotting0.78295305
124MP0000653_abnormal_sex_gland0.77446000
125MP0005384_cellular_phenotype0.77012245
126MP0009379_abnormal_foot_pigmentation0.76503449
127MP0001145_abnormal_male_reproductive0.75575771
128MP0003315_abnormal_perineum_morphology0.75424008
129* MP0000015_abnormal_ear_pigmentation0.75093477
130MP0001727_abnormal_embryo_implantation0.73868517
131MP0002735_abnormal_chemical_nociception0.73385807
132MP0000750_abnormal_muscle_regeneration0.73193570
133MP0005379_endocrine/exocrine_gland_phen0.72953236
134MP0001970_abnormal_pain_threshold0.70827114
135MP0002638_abnormal_pupillary_reflex0.70380985
136MP0003698_abnormal_male_reproductive0.69878957
137MP0002102_abnormal_ear_morphology0.69668535
138MP0003136_yellow_coat_color0.69180926
139MP0004133_heterotaxia0.69056800
140MP0009745_abnormal_behavioral_response0.68914974
141MP0008872_abnormal_physiological_respon0.68879756
142MP0001984_abnormal_olfaction0.68775245

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.46005536
2Aplastic anemia (HP:0001915)3.77580062
3Abnormal number of erythroid precursors (HP:0012131)3.74433834
4Patellar aplasia (HP:0006443)3.71765491
5Abnormality of cells of the erythroid lineage (HP:0012130)3.54266420
6Abnormal mitochondria in muscle tissue (HP:0008316)3.46897238
7Microvesicular hepatic steatosis (HP:0001414)3.43027767
8Aplasia/Hypoplasia of the patella (HP:0006498)3.42955008
9Breast hypoplasia (HP:0003187)3.42931536
10Acute necrotizing encephalopathy (HP:0006965)3.32315888
11Abnormality of the heme biosynthetic pathway (HP:0010472)3.24600787
12Type I transferrin isoform profile (HP:0003642)3.16525905
13Retinal dysplasia (HP:0007973)3.07433927
14Abnormal gallbladder physiology (HP:0012438)3.06754837
15Cholecystitis (HP:0001082)3.06754837
16Petechiae (HP:0000967)3.06418134
17Increased intramyocellular lipid droplets (HP:0012240)3.04498967
18Reticulocytopenia (HP:0001896)2.96195717
19IgM deficiency (HP:0002850)2.94938789
20Abnormality of the anterior horn cell (HP:0006802)2.92389276
21Degeneration of anterior horn cells (HP:0002398)2.92389276
22Progressive microcephaly (HP:0000253)2.85705820
23Acute encephalopathy (HP:0006846)2.85584695
24Thrombocytosis (HP:0001894)2.81283492
25Increased muscle lipid content (HP:0009058)2.79040873
26Abnormal hair whorl (HP:0010721)2.73689471
27Oral leukoplakia (HP:0002745)2.70065100
28Type 2 muscle fiber atrophy (HP:0003554)2.67268436
29Elevated erythrocyte sedimentation rate (HP:0003565)2.66555058
3011 pairs of ribs (HP:0000878)2.63096601
31Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.56463295
32Decreased activity of mitochondrial respiratory chain (HP:0008972)2.56463295
33Lipid accumulation in hepatocytes (HP:0006561)2.54150220
34Meckel diverticulum (HP:0002245)2.53768231
35Muscle fiber atrophy (HP:0100295)2.52403016
36Hypertensive crisis (HP:0100735)2.50765941
37Abnormality of the ileum (HP:0001549)2.50324656
38Bone marrow hypocellularity (HP:0005528)2.49889814
39Hepatocellular necrosis (HP:0001404)2.49605214
40Hyperthyroidism (HP:0000836)2.49024997
41Poikiloderma (HP:0001029)2.48740304
42Cerebral hypomyelination (HP:0006808)2.47677048
43Abnormality of reticulocytes (HP:0004312)2.43191969
44Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.42129777
45Abnormal protein N-linked glycosylation (HP:0012347)2.42129777
46Abnormal protein glycosylation (HP:0012346)2.42129777
47Abnormal glycosylation (HP:0012345)2.42129777
48Chromsome breakage (HP:0040012)2.42099898
49Lactic acidosis (HP:0003128)2.41866138
50Myokymia (HP:0002411)2.40901722
51B lymphocytopenia (HP:0010976)2.39459421
52Abnormality of B cell number (HP:0010975)2.39459421
53Severe visual impairment (HP:0001141)2.39365330
54Abnormality of the preputium (HP:0100587)2.39283957
55Premature graying of hair (HP:0002216)2.37839300
56Exercise intolerance (HP:0003546)2.37488942
57Myelodysplasia (HP:0002863)2.36765684
58Renal Fanconi syndrome (HP:0001994)2.36113391
59Abnormality of DNA repair (HP:0003254)2.34256922
60Ragged-red muscle fibers (HP:0003200)2.33951918
61Rough bone trabeculation (HP:0100670)2.31783180
62Progressive macrocephaly (HP:0004481)2.29392784
63Aplasia/Hypoplasia of the uvula (HP:0010293)2.28685250
64Microretrognathia (HP:0000308)2.26382044
65Broad distal phalanx of finger (HP:0009836)2.25925658
66Unsteady gait (HP:0002317)2.23945015
67Abnormal lung lobation (HP:0002101)2.23497177
68Slender long bone (HP:0003100)2.22881474
69Chromosomal breakage induced by crosslinking agents (HP:0003221)2.22090048
70Exertional dyspnea (HP:0002875)2.20924798
71Agnosia (HP:0010524)2.20265861
72Increased serum lactate (HP:0002151)2.19811436
73Lymphoma (HP:0002665)2.19446379
74Abnormal number of incisors (HP:0011064)2.16778212
75Emotional lability (HP:0000712)2.16678653
76Abnormality of chromosome stability (HP:0003220)2.15470512
77Respiratory difficulties (HP:0002880)2.15382674
78Tongue fasciculations (HP:0001308)2.15197847
79Horseshoe kidney (HP:0000085)2.15128853
80Optic nerve coloboma (HP:0000588)2.15036304
81Reduced antithrombin III activity (HP:0001976)2.13586970
82Small intestinal stenosis (HP:0012848)2.13344792
83Duodenal stenosis (HP:0100867)2.13344792
84Medulloblastoma (HP:0002885)2.13205196
85Hyperglycinemia (HP:0002154)2.10859787
86Testicular atrophy (HP:0000029)2.10485125
87Opisthotonus (HP:0002179)2.09673672
88Hepatic necrosis (HP:0002605)2.09642345
89Severe combined immunodeficiency (HP:0004430)2.09507557
90Atrophy/Degeneration involving motor neurons (HP:0007373)2.05593504
91Panhypogammaglobulinemia (HP:0003139)2.04971832
92CNS hypomyelination (HP:0003429)2.04681380
93Aplasia/Hypoplasia of the thymus (HP:0010515)2.03367975
94Pulmonary fibrosis (HP:0002206)2.03260238
95Poor suck (HP:0002033)2.02652424
96Aplasia/Hypoplasia of the sacrum (HP:0008517)2.02243556
97Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.99675035
98Combined immunodeficiency (HP:0005387)1.98061284
99Pancytopenia (HP:0001876)1.97823067
100Pallor (HP:0000980)1.96485135
101Increased IgM level (HP:0003496)1.96284324
102Increased CSF lactate (HP:0002490)1.95499183
103Failure to thrive in infancy (HP:0001531)1.95318054
104Squamous cell carcinoma (HP:0002860)1.95204057
105IgG deficiency (HP:0004315)1.94711212
106Entropion (HP:0000621)1.93676797
107Impulsivity (HP:0100710)1.91072133
108Macrocytic anemia (HP:0001972)1.90731222
109Abnormality of glycolysis (HP:0004366)1.90181584
110Secondary amenorrhea (HP:0000869)1.89924940
111Absent thumb (HP:0009777)1.89256420
112Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.88273153
113Type II lissencephaly (HP:0007260)1.87924928
114Poor head control (HP:0002421)1.87454195
115Carpal bone hypoplasia (HP:0001498)1.86723472
116Mitochondrial inheritance (HP:0001427)1.86528722
117Patent foramen ovale (HP:0001655)1.86078165
118Abnormality of homocysteine metabolism (HP:0010919)1.85789868
119Homocystinuria (HP:0002156)1.85789868
120Prominent metopic ridge (HP:0005487)1.85753579
121Abnormality of dicarboxylic acid metabolism (HP:0010995)1.84860945
122Dicarboxylic aciduria (HP:0003215)1.84860945
1233-Methylglutaconic aciduria (HP:0003535)1.84715625
124Cleft eyelid (HP:0000625)1.83507864
125Clubbing of toes (HP:0100760)1.83455342
126Abnormality of the labia minora (HP:0012880)1.82667494
127Colon cancer (HP:0003003)1.82635107
128True hermaphroditism (HP:0010459)1.82622402
129Truncus arteriosus (HP:0001660)1.82414893
130Hypoplasia of the capital femoral epiphysis (HP:0003090)1.81142828
131Oligodactyly (HP:0012165)1.79509060
132Lissencephaly (HP:0001339)1.79243765
133Neoplasm of the adrenal cortex (HP:0100641)1.78719717
134Abnormality of lateral ventricle (HP:0030047)1.78591463
135Dysphonia (HP:0001618)1.77494223
136Cerebellar hypoplasia (HP:0001321)1.77417034
137Sloping forehead (HP:0000340)1.77326215
138Rib fusion (HP:0000902)1.77055901
139Progressive muscle weakness (HP:0003323)1.75922664
140Neutropenia (HP:0001875)1.73259698
141Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.72544314
142Cerebral palsy (HP:0100021)1.72061254
143Personality changes (HP:0000751)1.71220254
144Increased hepatocellular lipid droplets (HP:0006565)1.71153500
145Granulocytopenia (HP:0001913)1.70876779
146Muscle fibrillation (HP:0010546)1.70647431
147Pendular nystagmus (HP:0012043)1.70644200
148Abnormality of the duodenum (HP:0002246)1.70242905
149Cellular immunodeficiency (HP:0005374)1.69745119
150Agammaglobulinemia (HP:0004432)1.69578703
151Severe global developmental delay (HP:0011344)1.68890072
152Abnormality of the fingertips (HP:0001211)1.68566058
153Tracheoesophageal fistula (HP:0002575)1.68486906
154Abnormality of the intervertebral disk (HP:0005108)1.68056667
155Respiratory failure (HP:0002878)1.67688750
156Premature ovarian failure (HP:0008209)1.67653808
157Abnormality of the metopic suture (HP:0005556)1.67626282
158Reticulocytosis (HP:0001923)1.65831847
159Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.65454331

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.29308676
2BUB13.63341412
3CCNB12.81024619
4WEE12.79573553
5EIF2AK12.72503103
6CDC72.72218111
7STK162.67998135
8BMPR1B2.53201729
9PIM22.51401943
10ARAF2.49644562
11ACVR1B2.45381075
12PASK2.40660100
13BRAF2.32003556
14CDK82.09920606
15BRSK12.03865392
16SMG11.99237746
17SRPK11.97931045
18PLK41.95151193
19IRAK31.93825735
20BRSK21.90640335
21SIK31.90306139
22EIF2AK31.90113164
23TSSK61.89880916
24TGFBR11.83614348
25MAP4K21.70494049
26VRK11.69694697
27MAP3K121.62697449
28PLK11.60463370
29MAP4K11.59940298
30CSNK1G31.58651569
31TAOK31.53856673
32MKNK11.53672472
33NME21.45495305
34ZAK1.45427096
35TRIM281.44959524
36TLK11.44229271
37PLK31.37870561
38TESK21.33069151
39RPS6KA41.29668453
40KDR1.28669248
41SIK21.23861558
42MAP3K111.21321813
43ATR1.20251678
44TNK21.16997678
45LIMK11.15686624
46CSNK1G21.14333992
47CSNK1A1L1.14079985
48DYRK21.09078421
49DYRK31.08977477
50CDK71.07161331
51AURKA1.06919392
52TTK1.06164049
53NEK21.05569825
54DAPK11.03652346
55CHEK21.01841210
56ZAP701.00721601
57TXK1.00693645
58MAP3K60.98383194
59RAF10.96832698
60MKNK20.95781292
61LRRK20.94090318
62PIM10.93880095
63TAOK20.92109463
64STK240.91917031
65PRKD30.90846298
66ICK0.90342331
67AURKB0.90161648
68BTK0.87283444
69NUAK10.86613640
70SCYL20.86567115
71BMX0.84528522
72DYRK1B0.84452959
73PRPF4B0.80408019
74NEK10.79905727
75TESK10.78830714
76BMPR20.76425961
77CSNK1G10.75760152
78STK100.74677339
79SYK0.74618185
80AKT30.69645571
81CDK140.69293788
82IRAK40.68795513
83TYK20.68023188
84KIT0.64937332
85MAP2K70.64718596
86CHEK10.64675319
87STK38L0.64648685
88CLK10.64006673
89MAP3K80.62606363
90MAP2K30.61658947
91MAPK130.61074361
92CDK11A0.60955837
93MAPKAPK30.59825329
94CSNK2A10.59813530
95TEC0.58978750
96EIF2AK20.58356924
97RPS6KB20.57964016
98CASK0.57570424
99PRKCI0.57102452
100YES10.55419170
101CDK150.55261334
102EEF2K0.54014848
103CDK190.53688508
104CDK180.53656925
105ABL20.51796943
106BLK0.51101443
107PRKD20.49964688
108CDK40.49315791
109CSF1R0.48857100
110ERN10.48842139
111RPS6KA60.48374561
112GRK60.47948072
113ERBB30.47810253
114SIK10.47699019
115RPS6KA50.47431535
116DAPK30.47317691
117MAPKAPK50.46685463
118LYN0.46469483
119CHUK0.45893220
120TAOK10.45509360
121RPS6KL10.45284644
122RPS6KC10.45284644
123NME10.44860658
124CSNK2A20.44760441
125PAK40.44516646
126TBK10.44361034
127PLK20.44140898
128PAK10.43580182
129BCKDK0.43537772
130MAP2K40.43086539
131IKBKB0.42731796
132CDK20.42369788
133ATM0.40732010
134MOS0.39375700
135MAPKAPK20.39112910
136FES0.37971286
137TRIB30.37724330
138GRK50.37585544
139CAMKK10.36330350
140MARK20.31567778
141MATK0.31049571
142MAP2K20.30978807
143NTRK20.25838652

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.74292436
2Mismatch repair_Homo sapiens_hsa034303.82595975
3Proteasome_Homo sapiens_hsa030503.76552307
4Base excision repair_Homo sapiens_hsa034103.51390220
5Sulfur relay system_Homo sapiens_hsa041223.39995149
6RNA polymerase_Homo sapiens_hsa030203.33913084
7Homologous recombination_Homo sapiens_hsa034403.15025306
8Ribosome_Homo sapiens_hsa030102.98929976
9Spliceosome_Homo sapiens_hsa030402.92828944
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.65765490
11Nucleotide excision repair_Homo sapiens_hsa034202.59127628
12Non-homologous end-joining_Homo sapiens_hsa034502.58043456
13Pyrimidine metabolism_Homo sapiens_hsa002402.53879670
14Cell cycle_Homo sapiens_hsa041102.41822223
15RNA transport_Homo sapiens_hsa030132.29305380
16RNA degradation_Homo sapiens_hsa030182.15661974
17Protein export_Homo sapiens_hsa030601.96957036
18Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.95689989
19Basal transcription factors_Homo sapiens_hsa030221.95045767
20Fanconi anemia pathway_Homo sapiens_hsa034601.84787690
21One carbon pool by folate_Homo sapiens_hsa006701.74956206
222-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.69108958
23Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.55388277
24Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.50749377
25Primary immunodeficiency_Homo sapiens_hsa053401.46437936
26Purine metabolism_Homo sapiens_hsa002301.41679040
27Fatty acid elongation_Homo sapiens_hsa000621.34427809
28mRNA surveillance pathway_Homo sapiens_hsa030151.30423485
29Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.23876870
30Epstein-Barr virus infection_Homo sapiens_hsa051691.22607427
31Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.17599805
32Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.13566133
33p53 signaling pathway_Homo sapiens_hsa041151.09495369
34Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.07127244
35Carbon metabolism_Homo sapiens_hsa012001.02526417
36Herpes simplex infection_Homo sapiens_hsa051681.01103785
37Cyanoamino acid metabolism_Homo sapiens_hsa004600.97801014
38Synaptic vesicle cycle_Homo sapiens_hsa047210.97131328
39Other glycan degradation_Homo sapiens_hsa005110.96058198
40Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.91444215
41Antigen processing and presentation_Homo sapiens_hsa046120.91225541
42Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.87612728
43Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.84866364
44N-Glycan biosynthesis_Homo sapiens_hsa005100.83010961
45Huntingtons disease_Homo sapiens_hsa050160.82412960
46Parkinsons disease_Homo sapiens_hsa050120.82144981
47Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.81881636
48SNARE interactions in vesicular transport_Homo sapiens_hsa041300.79945043
49Shigellosis_Homo sapiens_hsa051310.78620690
50Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.76932748
51Steroid biosynthesis_Homo sapiens_hsa001000.74811690
52Legionellosis_Homo sapiens_hsa051340.73923439
53Cardiac muscle contraction_Homo sapiens_hsa042600.72162898
54Oocyte meiosis_Homo sapiens_hsa041140.71688077
55Galactose metabolism_Homo sapiens_hsa000520.71332714
56Oxidative phosphorylation_Homo sapiens_hsa001900.68403963
57Colorectal cancer_Homo sapiens_hsa052100.66934234
58HTLV-I infection_Homo sapiens_hsa051660.66450000
59Measles_Homo sapiens_hsa051620.64914839
60Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.62278756
61Vibrio cholerae infection_Homo sapiens_hsa051100.62265043
62NF-kappa B signaling pathway_Homo sapiens_hsa040640.60623097
63Glutathione metabolism_Homo sapiens_hsa004800.59520257
64Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.59398342
65Nicotine addiction_Homo sapiens_hsa050330.56686337
66Drug metabolism - other enzymes_Homo sapiens_hsa009830.56504800
67Cysteine and methionine metabolism_Homo sapiens_hsa002700.55883967
68Apoptosis_Homo sapiens_hsa042100.55823842
69Thyroid cancer_Homo sapiens_hsa052160.54547423
70Regulation of autophagy_Homo sapiens_hsa041400.52554197
71Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.52549712
72RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.51431008
73Viral carcinogenesis_Homo sapiens_hsa052030.51112400
74Selenocompound metabolism_Homo sapiens_hsa004500.50759413
75Collecting duct acid secretion_Homo sapiens_hsa049660.49042825
76Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.48898971
77Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.48764424
78Hepatitis B_Homo sapiens_hsa051610.48541446
79Intestinal immune network for IgA production_Homo sapiens_hsa046720.47597744
80Hematopoietic cell lineage_Homo sapiens_hsa046400.46489324
81Pyruvate metabolism_Homo sapiens_hsa006200.44508417
82Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.42080657
83Leishmaniasis_Homo sapiens_hsa051400.41889162
84Arachidonic acid metabolism_Homo sapiens_hsa005900.40930644
85Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.40547336
86Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.39665146
87Transcriptional misregulation in cancer_Homo sapiens_hsa052020.38399939
88Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.37424388
89Folate biosynthesis_Homo sapiens_hsa007900.37186242
90Influenza A_Homo sapiens_hsa051640.37086753
91Fructose and mannose metabolism_Homo sapiens_hsa000510.36184375
92Pentose phosphate pathway_Homo sapiens_hsa000300.35883436
93Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.35820399
94Acute myeloid leukemia_Homo sapiens_hsa052210.34697393
95Biosynthesis of amino acids_Homo sapiens_hsa012300.34476219
96Pancreatic cancer_Homo sapiens_hsa052120.32719628
97Basal cell carcinoma_Homo sapiens_hsa052170.32558706
98Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.32105143
99Endometrial cancer_Homo sapiens_hsa052130.31678006
100Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.31387322
101Glycosaminoglycan degradation_Homo sapiens_hsa005310.30578869
102B cell receptor signaling pathway_Homo sapiens_hsa046620.30020416
103Peroxisome_Homo sapiens_hsa041460.29967248
104Notch signaling pathway_Homo sapiens_hsa043300.29386989
105Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.28279646
106Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.26399183
107Vitamin B6 metabolism_Homo sapiens_hsa007500.25772872
108Alzheimers disease_Homo sapiens_hsa050100.24753990
109Jak-STAT signaling pathway_Homo sapiens_hsa046300.24101551
110Non-small cell lung cancer_Homo sapiens_hsa052230.21459286
111Alcoholism_Homo sapiens_hsa050340.21305999
112Lysosome_Homo sapiens_hsa041420.21210350
113Endocytosis_Homo sapiens_hsa041440.20591355
114Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.19691876
115Chronic myeloid leukemia_Homo sapiens_hsa052200.19348126
116Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.19049472
117Salmonella infection_Homo sapiens_hsa051320.18873668
118Allograft rejection_Homo sapiens_hsa053300.18353693
119Small cell lung cancer_Homo sapiens_hsa052220.18265289
120Type I diabetes mellitus_Homo sapiens_hsa049400.18059017
121T cell receptor signaling pathway_Homo sapiens_hsa046600.17728092
122Linoleic acid metabolism_Homo sapiens_hsa005910.16975721
123Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.16422047
124Asthma_Homo sapiens_hsa053100.15740217
125Central carbon metabolism in cancer_Homo sapiens_hsa052300.15526400
126Phototransduction_Homo sapiens_hsa047440.15450127
127Hepatitis C_Homo sapiens_hsa051600.14721317
128GABAergic synapse_Homo sapiens_hsa047270.14270030
129Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.13862817
130Metabolic pathways_Homo sapiens_hsa011000.13743799
131Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.11852184
132Systemic lupus erythematosus_Homo sapiens_hsa053220.11371997
133Cocaine addiction_Homo sapiens_hsa050300.09151012
134Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.08900158
135Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.07209219
136Axon guidance_Homo sapiens_hsa043600.07159964

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