ACE

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an enzyme involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This enzyme plays a key role in the renin-angiotensin system. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme or cardiovascular pathophysiologies. Multiple alternatively spliced transcript variants encoding different isoforms have been identified, and two most abundant spliced variants encode the somatic form and the testicular form, respectively, that are equally active. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of guanylate cyclase activity (GO:0031282)7.63660308
2fat-soluble vitamin biosynthetic process (GO:0042362)6.87046746
3positive regulation of guanylate cyclase activity (GO:0031284)5.91380866
4* angiotensin maturation (GO:0002003)5.85571167
5intestinal absorption (GO:0050892)5.71861521
6intestinal cholesterol absorption (GO:0030299)5.32548684
7adhesion of symbiont to host cell (GO:0044650)5.05624770
8virion attachment to host cell (GO:0019062)5.05624770
9surfactant homeostasis (GO:0043129)4.93720901
10regulation of cGMP biosynthetic process (GO:0030826)4.83557992
11regulation of bile acid biosynthetic process (GO:0070857)4.82709051
12glycosphingolipid catabolic process (GO:0046479)4.69037046
13glycolipid catabolic process (GO:0019377)4.63140062
14regulation of cellular extravasation (GO:0002691)4.60147604
15vitamin A metabolic process (GO:0006776)4.57206337
16receptor guanylyl cyclase signaling pathway (GO:0007168)4.49866551
17very-low-density lipoprotein particle assembly (GO:0034379)4.48303225
18sexual reproduction (GO:0019953)4.36891210
19adhesion of symbiont to host (GO:0044406)4.31332555
20renal system process involved in regulation of blood volume (GO:0001977)4.14535700
21regulation of vitamin metabolic process (GO:0030656)4.03976179
22* regulation of systemic arterial blood pressure by hormone (GO:0001990)4.03283956
23* regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)4.03283956
24* endocrine process (GO:0050886)4.03283956
25regulation of cGMP metabolic process (GO:0030823)4.02650877
26drug catabolic process (GO:0042737)3.98499440
27chemical homeostasis within a tissue (GO:0048875)3.88501078
28ceramide catabolic process (GO:0046514)3.82804351
29* regulation of systemic arterial blood pressure (GO:0003073)3.80629669
30positive regulation of cGMP biosynthetic process (GO:0030828)3.62714872
31sphingolipid catabolic process (GO:0030149)3.58284620
32actin filament depolymerization (GO:0030042)3.56765695
33bundle of His cell to Purkinje myocyte communication (GO:0086069)3.56761672
34urea cycle (GO:0000050)3.55677260
35regulation of endothelial cell differentiation (GO:0045601)3.54853064
36artery development (GO:0060840)3.52458578
37bile acid and bile salt transport (GO:0015721)3.50644820
38* peptide hormone processing (GO:0016486)3.50593797
39membrane lipid catabolic process (GO:0046466)3.49274714
40vitamin transmembrane transport (GO:0035461)3.46652433
41vitamin transport (GO:0051180)3.41000139
42fat-soluble vitamin metabolic process (GO:0006775)3.40939918
43urea metabolic process (GO:0019627)3.39816251
44positive regulation of p38MAPK cascade (GO:1900745)3.38175028
45regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.33695468
46homocysteine metabolic process (GO:0050667)3.27246638
47organic cation transport (GO:0015695)3.26728766
48transepithelial transport (GO:0070633)3.26415243
49alkaloid metabolic process (GO:0009820)3.25677541
50flavonoid metabolic process (GO:0009812)3.25338777
51cGMP-mediated signaling (GO:0019934)3.24927005
52regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.24921847
53drinking behavior (GO:0042756)3.22835899
54regulation of p38MAPK cascade (GO:1900744)3.22695805
55vitamin D metabolic process (GO:0042359)3.18339909
56leukotriene metabolic process (GO:0006691)3.18011515
57antimicrobial humoral response (GO:0019730)3.17553378
58drug transmembrane transport (GO:0006855)3.16981523
59hemidesmosome assembly (GO:0031581)3.16821327
60regulation of triglyceride catabolic process (GO:0010896)3.16812707
61vitamin biosynthetic process (GO:0009110)3.16070660
62regulation of cholesterol esterification (GO:0010872)3.15972207
63antibacterial humoral response (GO:0019731)3.13703935
64positive regulation of triglyceride lipase activity (GO:0061365)3.13408604
65positive regulation of lipoprotein lipase activity (GO:0051006)3.13408604
66nitrogen cycle metabolic process (GO:0071941)3.13383555
67positive regulation of cGMP metabolic process (GO:0030825)3.13053818
68blood vessel maturation (GO:0001955)3.11545581
69maintenance of gastrointestinal epithelium (GO:0030277)3.09246765
70phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.08472881
71cellular response to nitric oxide (GO:0071732)3.06375741
72glycosylceramide metabolic process (GO:0006677)3.04831395
73positive regulation of pseudopodium assembly (GO:0031274)3.04822668
74uronic acid metabolic process (GO:0006063)3.04166352
75glucuronate metabolic process (GO:0019585)3.04166352
76cellular glucuronidation (GO:0052695)3.02538655
77modified amino acid transport (GO:0072337)3.01431737
78sphingomyelin metabolic process (GO:0006684)2.99438320
79renal absorption (GO:0070293)2.97764576
80drug transport (GO:0015893)2.96117831
81morphogenesis of an endothelium (GO:0003159)2.94147112
82endothelial tube morphogenesis (GO:0061154)2.94147112
83phenol-containing compound catabolic process (GO:0019336)2.93306635
84antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.93297422
85sperm capacitation (GO:0048240)2.91941160
86glycerol metabolic process (GO:0006071)2.91059466
87polyol transport (GO:0015791)2.89081776
88epithelial cell-cell adhesion (GO:0090136)2.88826296
89positive regulation of glycoprotein biosynthetic process (GO:0010560)2.88494523
90amino-acid betaine transport (GO:0015838)2.87451819
91carnitine transport (GO:0015879)2.87451819
92renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)2.86764253
93cobalamin metabolic process (GO:0009235)2.85400766
94arachidonic acid metabolic process (GO:0019369)2.83858867
95antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.82987577
96transcytosis (GO:0045056)2.82782808
97response to phenylpropanoid (GO:0080184)2.82515812
98renal filtration (GO:0097205)2.80805686
99regulation of vasculogenesis (GO:2001212)2.78045898
100antigen processing and presentation of endogenous antigen (GO:0019883)2.77748173
101apoptotic cell clearance (GO:0043277)2.76969013
102arginine metabolic process (GO:0006525)2.76616981
103NADH metabolic process (GO:0006734)2.76261277
104positive regulation of lipid catabolic process (GO:0050996)2.75842262
105exogenous drug catabolic process (GO:0042738)2.75288139
106regulation of pseudopodium assembly (GO:0031272)2.75068703
107plasma lipoprotein particle organization (GO:0071827)2.74890653
108cellular carbohydrate catabolic process (GO:0044275)2.74491509
109bile acid metabolic process (GO:0008206)2.73232801
110lipoprotein transport (GO:0042953)2.72543153
111negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.72455575
112positive regulation of endothelial cell differentiation (GO:0045603)2.71307699
113eosinophil chemotaxis (GO:0048245)2.70553997
114oligosaccharide catabolic process (GO:0009313)2.69677455
115cellular response to reactive nitrogen species (GO:1902170)2.69664262
116cytoskeletal anchoring at plasma membrane (GO:0007016)2.67966762
117lysine catabolic process (GO:0006554)2.67435299
118lysine metabolic process (GO:0006553)2.67435299
119retina vasculature morphogenesis in camera-type eye (GO:0061299)2.66547723
120respiratory tube development (GO:0030323)2.66110542
121lipoprotein metabolic process (GO:0042157)2.65231158
122triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.65103916
123quaternary ammonium group transport (GO:0015697)2.64503507
124epoxygenase P450 pathway (GO:0019373)2.64129549
125skeletal muscle adaptation (GO:0043501)2.62640866
126digestive system process (GO:0022600)2.62107613
127regulation of cholesterol homeostasis (GO:2000188)2.61496753
128protein localization to endosome (GO:0036010)2.58606309
129phospholipid efflux (GO:0033700)2.58035917
130* regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.57819653
131glucose 6-phosphate metabolic process (GO:0051156)2.56375063
132low-density lipoprotein particle clearance (GO:0034383)2.54731402
133drug metabolic process (GO:0017144)2.53916643
134striated muscle atrophy (GO:0014891)2.51998023
135digestion (GO:0007586)2.50769048
136UDP-N-acetylglucosamine metabolic process (GO:0006047)2.50368827
137fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.48175144
138lymphangiogenesis (GO:0001946)2.47575040
139cGMP biosynthetic process (GO:0006182)2.44784593
140hypotonic response (GO:0006971)2.42432498
141cholesterol efflux (GO:0033344)2.41890540
142diacylglycerol metabolic process (GO:0046339)2.41412563
143protein targeting to Golgi (GO:0000042)2.39845314
144protein-lipid complex assembly (GO:0065005)2.37220506
145beta-amyloid metabolic process (GO:0050435)2.36262137
146vascular endothelial growth factor signaling pathway (GO:0038084)2.35008288
147positive regulation of fatty acid biosynthetic process (GO:0045723)2.35007734
148bicarbonate transport (GO:0015701)2.34896639
149glomerular filtration (GO:0003094)2.34571159
150response to hepatocyte growth factor (GO:0035728)2.34564050
151cellular response to hepatocyte growth factor stimulus (GO:0035729)2.34564050
152positive regulation of triglyceride metabolic process (GO:0090208)2.33870323
153sulfur compound transport (GO:0072348)2.33352098
154plasma lipoprotein particle assembly (GO:0034377)2.32553506
155protein kinase C signaling (GO:0070528)2.31746531
156sperm motility (GO:0030317)2.31211216
157response to nitric oxide (GO:0071731)2.30817018
158fructose metabolic process (GO:0006000)2.30339225
159carnitine transmembrane transport (GO:1902603)2.30042944
160sterol homeostasis (GO:0055092)2.29857395
161sterol transport (GO:0015918)2.28193894
162cholesterol transport (GO:0030301)2.28193894
163phosphate ion transmembrane transport (GO:0035435)2.28109925
164cholesterol homeostasis (GO:0042632)2.27848994

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human3.97951556
2TP63_17297297_ChIP-ChIP_HaCaT_Human3.48765231
3TRIM28_21343339_ChIP-Seq_HEK293_Human2.99232709
4IRF8_22096565_ChIP-ChIP_GC-B_Human2.71183756
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.68647819
6CDX2_20551321_ChIP-Seq_CACO-2_Human2.55421713
7STAT6_21828071_ChIP-Seq_BEAS2B_Human2.50175175
8ESR2_21235772_ChIP-Seq_MCF-7_Human2.20692425
9SOX2_27498859_Chip-Seq_STOMACH_Mouse2.19271360
10CLOCK_20551151_ChIP-Seq_293T_Human2.16555486
11LXR_22158963_ChIP-Seq_LIVER_Mouse2.02014391
12ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.00308749
13CDX2_19796622_ChIP-Seq_MESCs_Mouse1.98551882
14GATA1_22025678_ChIP-Seq_K562_Human1.96298600
15ESR1_21235772_ChIP-Seq_MCF-7_Human1.94713651
16CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.83836913
17RARG_19884340_ChIP-ChIP_MEFs_Mouse1.78492542
18PPAR_26484153_Chip-Seq_NCI-H1993_Human1.78114897
19IRF8_21731497_ChIP-ChIP_J774_Mouse1.77592867
20PPARA_22158963_ChIP-Seq_LIVER_Mouse1.72246682
21GATA2_21666600_ChIP-Seq_HMVEC_Human1.70351011
22EP300_21415370_ChIP-Seq_HL-1_Mouse1.69295423
23TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.68648711
24PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.66076731
25BCL6_27268052_Chip-Seq_Bcells_Human1.64817417
26TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.62501578
27* GATA4_25053715_ChIP-Seq_YYC3_Human1.61824011
28RXR_22158963_ChIP-Seq_LIVER_Mouse1.57963269
29SOX2_20726797_ChIP-Seq_SW620_Human1.56945579
30BCOR_27268052_Chip-Seq_Bcells_Human1.56629261
31TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.56084599
32ZNF217_24962896_ChIP-Seq_MCF-7_Human1.54993412
33ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.52966117
34ZNF263_19887448_ChIP-Seq_K562_Human1.51726167
35FOXO3_23340844_ChIP-Seq_DLD1_Human1.50058286
36TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.48898959
37TBX20_22328084_ChIP-Seq_HEART_Mouse1.48563509
38TBX20_22080862_ChIP-Seq_HEART_Mouse1.48563509
39RUNX1_27514584_Chip-Seq_MCF-7_Human1.47174319
40NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.45228943
41NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.43549809
42SA1_27219007_Chip-Seq_Bcells_Human1.40462089
43ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.38666626
44VDR_24787735_ChIP-Seq_THP-1_Human1.35481555
45ESR1_20079471_ChIP-ChIP_T-47D_Human1.35052169
46* GATA6_25053715_ChIP-Seq_YYC3_Human1.31495533
47AHR_22903824_ChIP-Seq_MCF-7_Human1.31304577
48* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.31094453
49EGR1_23403033_ChIP-Seq_LIVER_Mouse1.30630109
50KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.29485843
51NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.28194354
52FOXA2_19822575_ChIP-Seq_HepG2_Human1.27919351
53* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.26948481
54CJUN_26792858_Chip-Seq_BT549_Human1.26853637
55RACK7_27058665_Chip-Seq_MCF-7_Human1.26175538
56VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.22240984
57SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.19163814
58IRF8_27001747_Chip-Seq_BMDM_Mouse1.18585998
59KLF5_25053715_ChIP-Seq_YYC3_Human1.18433028
60VDR_24763502_ChIP-Seq_THP-1_Human1.17760887
61HIF1A_21447827_ChIP-Seq_MCF-7_Human1.17548212
62* TET1_21451524_ChIP-Seq_MESCs_Mouse1.17497625
63PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.16794915
64SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.16792506
65NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.15527826
66DROSHA_22980978_ChIP-Seq_HELA_Human1.13465992
67P68_20966046_ChIP-Seq_HELA_Human1.13200320
68TCF4_18268006_ChIP-ChIP_LS174T_Human1.11426008
69GATA2_19941826_ChIP-Seq_K562_Human1.11193075
70SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.10689117
71AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.10182138
72NANOG_20526341_ChIP-Seq_ESCs_Human1.09582913
73BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.09499450
74PHF8_20622854_ChIP-Seq_HELA_Human1.08807991
75ARNT_22903824_ChIP-Seq_MCF-7_Human1.08752656
76SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.08652054
77HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.08341366
78IKZF1_21737484_ChIP-ChIP_HCT116_Human1.07055603
79* LXR_22292898_ChIP-Seq_THP-1_Human1.06511489
80* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.06490037
81* JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.05829691
82E2F1_20622854_ChIP-Seq_HELA_Human1.04733449
83STAT1_20625510_ChIP-Seq_HELA_Human1.02190138
84SMAD3_21741376_ChIP-Seq_HESCs_Human1.01756952
85* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.01715019
86FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.01664427
87GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.01652574
88IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.01095214
89CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00768395
90SMC4_20622854_ChIP-Seq_HELA_Human1.00704999
91RAD21_21589869_ChIP-Seq_MESCs_Mouse1.00243338
92JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.00006711
93STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.98881982
94MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.98845538
95THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.98455125
96GATA1_19941826_ChIP-Seq_K562_Human0.98441416
97SALL4_18804426_ChIP-ChIP_XEN_Mouse0.98217427
98SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.98202514
99* EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.97026486
100CTCF_20526341_ChIP-Seq_ESCs_Human0.96702738
101CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96663338
102PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95845885
103TAF2_19829295_ChIP-Seq_ESCs_Human0.95523915
104TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94748065
105CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.94747967
106FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.94457797
107JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.94295074
108SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.93964684
109E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.93843617
110* CTCF_27219007_Chip-Seq_ERYTHROID_Human0.93482155
111WT1_25993318_ChIP-Seq_PODOCYTE_Human0.93205614
112EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.93077433
113* DNAJC2_21179169_ChIP-ChIP_NT2_Human0.92437032
114SA1_27219007_Chip-Seq_ERYTHROID_Human0.91737157
115FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.91705760
116TP63_23658742_ChIP-Seq_EP156T_Human0.91601234
117CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.91577136
118ELK3_25401928_ChIP-Seq_HUVEC_Human0.91145156
119KDM2B_26808549_Chip-Seq_K562_Human0.90050713
120KDM2B_26808549_Chip-Seq_SUP-B15_Human0.89996028
121EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.89449728
122SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.89287093
123RXR_22108803_ChIP-Seq_LS180_Human0.88536460
124Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.88294370
125P300_27268052_Chip-Seq_Bcells_Human0.87660778
126FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.87351480
127TP63_22573176_ChIP-Seq_HFKS_Human0.86895084
128PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.86834864
129YY1_22570637_ChIP-Seq_MALME-3M_Human0.86768838
130P300_27058665_Chip-Seq_ZR-75-30cells_Human0.86633817
131VDR_21846776_ChIP-Seq_THP-1_Human0.86408338
132NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.85840666
133CTNNB1_20460455_ChIP-Seq_HCT116_Human0.85094733
134SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.84576204
135SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.84576204
136PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.83856109
137PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.83771039
138EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.83368636
139* CREB1_26743006_Chip-Seq_LNCaP_Human0.81674904
140* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.80874403
141RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.80810833
142ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.80798853
143SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80648876
144* ATF3_27146783_Chip-Seq_COLON_Human0.79273825
145HNF4A_19822575_ChIP-Seq_HepG2_Human0.78917058
146P63_26484246_Chip-Seq_KERATINOCYTES_Human0.75731231
147RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.74915375
148CTCF_27219007_Chip-Seq_Bcells_Human0.74852783
149NFIB_24661679_ChIP-Seq_LUNG_Mouse0.74811008

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis6.01180634
2MP0001666_abnormal_nutrient_absorption3.60972926
3MP0001958_emphysema3.22825715
4MP0010234_abnormal_vibrissa_follicle3.12693454
5MP0009379_abnormal_foot_pigmentation3.00938004
6MP0002139_abnormal_hepatobiliary_system2.79491746
7MP0008875_abnormal_xenobiotic_pharmacok2.75962184
8MP0004043_abnormal_pH_regulation2.64547978
9MP0003300_gastrointestinal_ulcer2.64218756
10MP0005167_abnormal_blood-brain_barrier2.62297496
11MP0010368_abnormal_lymphatic_system2.51085594
12MP0003705_abnormal_hypodermis_morpholog2.47806533
13MP0005409_darkened_coat_color2.43571341
14MP0009840_abnormal_foam_cell2.37907687
15MP0003183_abnormal_peptide_metabolism2.33522661
16MP0002138_abnormal_hepatobiliary_system2.29331241
17MP0003252_abnormal_bile_duct2.23267277
18MP0003191_abnormal_cellular_cholesterol2.14838245
19MP0004264_abnormal_extraembryonic_tissu2.05257130
20MP0004019_abnormal_vitamin_homeostasis2.00830834
21MP0001765_abnormal_ion_homeostasis1.99179880
22MP0004272_abnormal_basement_membrane1.97068809
23MP0000678_abnormal_parathyroid_gland1.94092513
24MP0001879_abnormal_lymphatic_vessel1.93932677
25MP0008438_abnormal_cutaneous_collagen1.90727232
26MP0005275_abnormal_skin_tensile1.90217215
27MP0004782_abnormal_surfactant_physiolog1.89384722
28* MP0005410_abnormal_fertilization1.89330696
29MP0010329_abnormal_lipoprotein_level1.87378126
30MP0000537_abnormal_urethra_morphology1.76647885
31MP0009780_abnormal_chondrocyte_physiolo1.69760151
32MP0000751_myopathy1.64098855
33* MP0009643_abnormal_urine_homeostasis1.61736935
34MP0000462_abnormal_digestive_system1.61036466
35MP0005451_abnormal_body_composition1.51906667
36MP0003879_abnormal_hair_cell1.51343623
37MP0006138_congestive_heart_failure1.48806809
38MP0000490_abnormal_crypts_of1.44735344
39MP0004084_abnormal_cardiac_muscle1.43289394
40MP0003866_abnormal_defecation1.43184439
41MP0003566_abnormal_cell_adhesion1.43041540
42MP0003868_abnormal_feces_composition1.42377887
43MP0003303_peritoneal_inflammation1.41877460
44MP0000538_abnormal_urinary_bladder1.40971858
45MP0006054_spinal_hemorrhage1.39909985
46MP0002796_impaired_skin_barrier1.34575610
47MP0005377_hearing/vestibular/ear_phenot1.32388777
48MP0003878_abnormal_ear_physiology1.32388777
49MP0003045_fibrosis1.32196456
50MP0002822_catalepsy1.29602519
51* MP0005332_abnormal_amino_acid1.29067465
52MP0001188_hyperpigmentation1.23234654
53* MP0005166_decreased_susceptibility_to1.21671658
54* MP0002136_abnormal_kidney_physiology1.21353296
55MP0005085_abnormal_gallbladder_physiolo1.20691531
56MP0008961_abnormal_basal_metabolism1.19340928
57MP0005535_abnormal_body_temperature1.19160176
58MP0002971_abnormal_brown_adipose1.18430109
59MP0005084_abnormal_gallbladder_morpholo1.18311198
60MP0002166_altered_tumor_susceptibility1.18015203
61MP0000477_abnormal_intestine_morphology1.17389227
62MP0006082_CNS_inflammation1.16019819
63* MP0001756_abnormal_urination1.14290589
64MP0009785_altered_susceptibility_to1.13747492
65MP0004147_increased_porphyrin_level1.13141540
66MP0005636_abnormal_mineral_homeostasis1.12094586
67MP0005666_abnormal_adipose_tissue1.11874853
68MP0001501_abnormal_sleep_pattern1.11789686
69MP0009115_abnormal_fat_cell1.11398578
70MP0003718_maternal_effect1.09861253
71MP0001664_abnormal_digestion1.09729701
72MP0004036_abnormal_muscle_relaxation1.06979568
73MP0010352_gastrointestinal_tract_polyps1.06972043
74MP0003436_decreased_susceptibility_to1.06473505
75MP0003828_pulmonary_edema1.04299113
76MP0002295_abnormal_pulmonary_circulatio1.04220666
77MP0000604_amyloidosis1.02460325
78MP0001873_stomach_inflammation1.01342890
79MP0001835_abnormal_antigen_presentation0.99998936
80MP0004858_abnormal_nervous_system0.99126068
81MP0002118_abnormal_lipid_homeostasis0.98064588
82* MP0001845_abnormal_inflammatory_respons0.97960093
83MP0005025_abnormal_response_to0.97488155
84MP0002148_abnormal_hypersensitivity_rea0.96855711
85MP0002876_abnormal_thyroid_physiology0.96546028
86MP0003806_abnormal_nucleotide_metabolis0.95983906
87MP0003950_abnormal_plasma_membrane0.95139017
88MP0002133_abnormal_respiratory_system0.94793522
89MP0005388_respiratory_system_phenotype0.94793522
90MP0000343_altered_response_to0.93554833
91MP0002254_reproductive_system_inflammat0.92400658
92MP0005330_cardiomyopathy0.91956640
93MP0008004_abnormal_stomach_pH0.91604980
94MP0005365_abnormal_bile_salt0.90845855
95MP0002089_abnormal_postnatal_growth/wei0.90642084
96MP0009384_cardiac_valve_regurgitation0.89228199
97MP0003724_increased_susceptibility_to0.88074065
98MP0000767_abnormal_smooth_muscle0.87239133
99MP0005381_digestive/alimentary_phenotyp0.86894434
100MP0005671_abnormal_response_to0.86405003
101MP0001790_abnormal_immune_system0.86169141
102MP0005387_immune_system_phenotype0.86169141
103MP0005174_abnormal_tail_pigmentation0.86140598
104* MP0008469_abnormal_protein_level0.85427374
105MP0004270_analgesia0.85415905
106MP0004130_abnormal_muscle_cell0.85169862
107MP0004484_altered_response_of0.84566058
108MP0010155_abnormal_intestine_physiology0.83475678
109MP0001663_abnormal_digestive_system0.83102537
110MP0002837_dystrophic_cardiac_calcinosis0.82883899
111MP0005670_abnormal_white_adipose0.82753998
112* MP0000249_abnormal_blood_vessel0.82653828
113* MP0000230_abnormal_systemic_arterial0.81693271
114MP0005165_increased_susceptibility_to0.80308457
115MP0002998_abnormal_bone_remodeling0.79185204
116MP0003091_abnormal_cell_migration0.78063721
117MP0005023_abnormal_wound_healing0.76717341
118* MP0001544_abnormal_cardiovascular_syste0.76592680
119* MP0005385_cardiovascular_system_phenoty0.76592680
120MP0005375_adipose_tissue_phenotype0.75703722
121MP0005058_abnormal_lysosome_morphology0.75645604
122MP0005310_abnormal_salivary_gland0.75103353
123MP0004947_skin_inflammation0.75054131
124MP0004185_abnormal_adipocyte_glucose0.74521768
125MP0001533_abnormal_skeleton_physiology0.74205256
126MP0001849_ear_inflammation0.73994666
127MP0004087_abnormal_muscle_fiber0.73990606
128MP0003329_amyloid_beta_deposits0.73942407
129MP0001485_abnormal_pinna_reflex0.73542572
130MP0002132_abnormal_respiratory_system0.72852167
131MP0002419_abnormal_innate_immunity0.71602796
132MP0000015_abnormal_ear_pigmentation0.70303877
133MP0002168_other_aberrant_phenotype0.70201035
134MP0002972_abnormal_cardiac_muscle0.70053254
135MP0005448_abnormal_energy_balance0.69230687
136MP0005164_abnormal_response_to0.68721469
137MP0000609_abnormal_liver_physiology0.67881029
138MP0004215_abnormal_myocardial_fiber0.67740021
139MP0000749_muscle_degeneration0.67554371
140MP0002896_abnormal_bone_mineralization0.67384768
141* MP0005584_abnormal_enzyme/coenzyme_acti0.67334687
142MP0003283_abnormal_digestive_organ0.66846483
143MP0002006_tumorigenesis0.66029326
144MP0003646_muscle_fatigue0.65799393
145MP0003172_abnormal_lysosome_physiology0.65612703
146* MP0009642_abnormal_blood_homeostasis0.63629681
147MP0000681_abnormal_thyroid_gland0.63032997
148MP0003075_altered_response_to0.62762785
149MP0000465_gastrointestinal_hemorrhage0.62556100
150* MP0001764_abnormal_homeostasis0.62168231
151MP0002098_abnormal_vibrissa_morphology0.60045413
152MP0009333_abnormal_splenocyte_physiolog0.59182450
153MP0005000_abnormal_immune_tolerance0.58044526

Predicted human phenotypes

RankGene SetZ-score
1Hyperactive renin-angiotensin system (HP:0000841)5.24194651
2Systemic lupus erythematosus (HP:0002725)5.09481343
3Chronic diarrhea (HP:0002028)4.83665076
4Polycythemia (HP:0001901)4.81888966
5Abnormality of the vitamin B12 metabolism (HP:0004341)4.70049529
6Ileus (HP:0002595)4.38565955
7Abnormality of vitamin B metabolism (HP:0004340)4.36985627
8Confusion (HP:0001289)4.34420039
9Right ventricular cardiomyopathy (HP:0011663)4.29373966
10Abnormality of glutamine family amino acid metabolism (HP:0010902)4.25470552
11Abnormality of the nasal mucosa (HP:0000433)3.82492299
12Malnutrition (HP:0004395)3.82296234
13Hematochezia (HP:0002573)3.80897872
14Hydroxyprolinuria (HP:0003080)3.75474464
15Abnormality of proline metabolism (HP:0010907)3.75474464
16Abnormality of chloride homeostasis (HP:0011422)3.72292608
17Nausea (HP:0002018)3.66894436
18Chronic bronchitis (HP:0004469)3.48408692
19Abnormality of vitamin metabolism (HP:0100508)3.46678631
20Enlarged epiphyses (HP:0010580)3.44453076
21Interstitial pulmonary disease (HP:0006530)3.42039092
22Glycosuria (HP:0003076)3.39249551
23Abnormality of urine glucose concentration (HP:0011016)3.39249551
24Congenital sensorineural hearing impairment (HP:0008527)3.32645340
25Hyperglycinuria (HP:0003108)3.23962966
26Xanthomatosis (HP:0000991)3.20661290
27Decreased circulating renin level (HP:0003351)3.18910227
28Hypophosphatemia (HP:0002148)3.13518788
29Abnormality of the costochondral junction (HP:0000919)3.09880680
30Steatorrhea (HP:0002570)2.98779010
31Autoimmune thrombocytopenia (HP:0001973)2.94399024
32Spontaneous hematomas (HP:0007420)2.90820616
33Increased connective tissue (HP:0009025)2.90659247
34Protuberant abdomen (HP:0001538)2.90147837
35Rectal prolapse (HP:0002035)2.89635040
36Aortic aneurysm (HP:0004942)2.88700449
37Abnormality of purine metabolism (HP:0004352)2.86494475
38Delayed epiphyseal ossification (HP:0002663)2.84485837
39Hypokalemic alkalosis (HP:0001949)2.84477448
40Pigmentary retinal degeneration (HP:0001146)2.84151045
41Mildly elevated creatine phosphokinase (HP:0008180)2.83444809
42Cerebral aneurysm (HP:0004944)2.75789174
43Gout (HP:0001997)2.71938233
44Acanthocytosis (HP:0001927)2.71797962
45Esophageal varix (HP:0002040)2.68556025
46Eczematoid dermatitis (HP:0000976)2.68380325
47Hyperparathyroidism (HP:0000843)2.65684462
48Hyperaldosteronism (HP:0000859)2.65074955
49Visceral angiomatosis (HP:0100761)2.63540153
50Dehydration (HP:0001944)2.61094975
51Focal segmental glomerulosclerosis (HP:0000097)2.57425835
52Muscle fiber splitting (HP:0003555)2.56350659
53Vacuolated lymphocytes (HP:0001922)2.54734609
54Gingivitis (HP:0000230)2.54584564
55Renal salt wasting (HP:0000127)2.54343097
56Megaloblastic anemia (HP:0001889)2.51403332
57Broad metatarsal (HP:0001783)2.50692149
58Glomerulonephritis (HP:0000099)2.48692942
59Abnormality of renin-angiotensin system (HP:0000847)2.48620102
60Hyperkalemia (HP:0002153)2.48268497
61Cardiovascular calcification (HP:0011915)2.45111776
62Hyporeflexia of lower limbs (HP:0002600)2.43214571
63Nephrolithiasis (HP:0000787)2.40502071
64Hemangiomatosis (HP:0007461)2.39845097
65Posterior subcapsular cataract (HP:0007787)2.39008667
66Abnormality of monocarboxylic acid metabolism (HP:0010996)2.33056217
67Abnormal urine phosphate concentration (HP:0012599)2.32784866
68Alkalosis (HP:0001948)2.32526742
69Vascular calcification (HP:0004934)2.29153746
70* Widely patent fontanelles and sutures (HP:0004492)2.27885188
71Cerebral hemorrhage (HP:0001342)2.27860030
72Male infertility (HP:0003251)2.26338921
73Mesangial abnormality (HP:0001966)2.25710941
74Thin bony cortex (HP:0002753)2.24329082
75Increased purine levels (HP:0004368)2.22508842
76Hyperuricemia (HP:0002149)2.22508842
77Ventricular tachycardia (HP:0004756)2.20988057
78Abnormality of nucleobase metabolism (HP:0010932)2.20862696
79Abnormality of glycosphingolipid metabolism (HP:0004343)2.18494851
80Abnormality of glycolipid metabolism (HP:0010969)2.18494851
81Abnormality of liposaccharide metabolism (HP:0010968)2.18494851
82Segmental peripheral demyelination/remyelination (HP:0003481)2.17173015
83Cupped ribs (HP:0000887)2.17172306
84Metabolic alkalosis (HP:0200114)2.14328437
85Hypobetalipoproteinemia (HP:0003563)2.13553139
86Complement deficiency (HP:0004431)2.13459617
87Metaphyseal irregularity (HP:0003025)2.12615046
88Aneurysm (HP:0002617)2.12319251
89Abnormality of glycine metabolism (HP:0010895)2.12307958
90Abnormality of serine family amino acid metabolism (HP:0010894)2.12307958
91Aortic dissection (HP:0002647)2.11138816
92Tubulointerstitial fibrosis (HP:0005576)2.10696781
93Abnormality of aspartate family amino acid metabolism (HP:0010899)2.10131693
94Shawl scrotum (HP:0000049)2.09617164
95Nasal polyposis (HP:0100582)2.08360003
96Milia (HP:0001056)2.07031316
97Hyperphosphaturia (HP:0003109)2.06338851
98Bundle branch block (HP:0011710)2.05407731
99Abnormality of complement system (HP:0005339)2.05308949
100Hyperammonemia (HP:0001987)2.04225274
101Sudden death (HP:0001699)2.03103538
102Ketoacidosis (HP:0001993)2.02932311
103Abnormality of magnesium homeostasis (HP:0004921)2.01914472
104Atrophic scars (HP:0001075)2.00785869
105Villous atrophy (HP:0011473)2.00698645
106Abnormality of small intestinal villus morphology (HP:0011472)2.00698645
107Axonal loss (HP:0003447)2.00482402
108Epidermoid cyst (HP:0200040)1.98143294
109Cerebral palsy (HP:0100021)1.97907105
110Hypomagnesemia (HP:0002917)1.95815048
111Long toe (HP:0010511)1.95721869
112Gastrointestinal dysmotility (HP:0002579)1.95314690
113Abnormality of macrophages (HP:0004311)1.94977868
114Hypoalbuminemia (HP:0003073)1.94535392
115Abnormal albumin level (HP:0012116)1.94535392
116Asymmetric septal hypertrophy (HP:0001670)1.94530108
117Multiple lipomas (HP:0001012)1.94326385
118Pancreatitis (HP:0001733)1.93750728
119Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.92506483
120Abdominal distention (HP:0003270)1.92174590
121Hemorrhage of the eye (HP:0011885)1.91954873
122Increased circulating renin level (HP:0000848)1.91712346
123Abnormal glucose tolerance (HP:0001952)1.91202076
124Glomerulosclerosis (HP:0000096)1.91112480
125Proximal tubulopathy (HP:0000114)1.91089614
126Abnormality of the vasculature of the conjunctiva (HP:0008054)1.89365889
127* Abnormality of renal excretion (HP:0011036)1.89168033
128Subcapsular cataract (HP:0000523)1.88817660
129Syncope (HP:0001279)1.88512398
130Facial diplegia (HP:0001349)1.88068612
131Peripheral demyelination (HP:0011096)1.87703951
132Nephritis (HP:0000123)1.87376312
133Abnormality of potassium homeostasis (HP:0011042)1.85650822
134Lymphangioma (HP:0100764)1.84739377
135Abnormality of sulfur amino acid metabolism (HP:0004339)1.83065649
136Dysostosis multiplex (HP:0000943)1.82581512
137Abnormality of alkaline phosphatase activity (HP:0004379)1.82328655
138Abnormality of the gastric mucosa (HP:0004295)1.82306645
139Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.81921712
140Abnormal enzyme/coenzyme activity (HP:0012379)1.81660006
141Hyperphosphatemia (HP:0002905)1.81082983
142Adrenal overactivity (HP:0002717)1.80461754
143Growth hormone excess (HP:0000845)1.79998890
144Fat malabsorption (HP:0002630)1.79786450
145Cavernous hemangioma (HP:0001048)1.79336640
146Ankle contracture (HP:0006466)1.78545385
147Hypokalemia (HP:0002900)1.77240324
148Difficulty running (HP:0009046)1.76814306
149Autoimmune hemolytic anemia (HP:0001890)1.76738971
150Tachypnea (HP:0002789)1.76186132
151Flat occiput (HP:0005469)1.76008638
152Bronchitis (HP:0012387)1.75282410
153Hypocalcemia (HP:0002901)1.75099909
154Bone cyst (HP:0012062)1.72994348
155Bone pain (HP:0002653)1.72855139
156Progressive sensorineural hearing impairment (HP:0000408)1.71934714
157Hand muscle atrophy (HP:0009130)1.71118288
158Irritability (HP:0000737)1.71113174
159Myoglobinuria (HP:0002913)1.71033414
160Dynein arm defect of respiratory motile cilia (HP:0012255)1.70774004
161Absent/shortened dynein arms (HP:0200106)1.70774004
162Increased cerebral lipofuscin (HP:0011813)1.70306783
163Loss of speech (HP:0002371)1.70241820
164Skin nodule (HP:0200036)1.69237954
165Petechiae (HP:0000967)1.68428324
166Hypolipoproteinemia (HP:0010981)1.68239483
167Metabolic acidosis (HP:0001942)1.66824528
168Stroke (HP:0001297)1.65192258

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B7.08858136
2TIE14.07897352
3FRK3.37128015
4MST43.31718156
5ERN13.21225422
6LMTK23.07090147
7AKT33.01751072
8RIPK12.67910481
9PDK42.52481942
10PDK32.52481942
11TGFBR22.42193590
12PDK22.32207348
13MST1R2.06711070
14MYLK2.01800159
15TESK12.01194778
16WNK41.98869279
17PTK61.98397178
18TESK21.90338196
19TRIB31.86417212
20EPHB11.78733536
21EPHB21.70822168
22RIPK41.68087001
23TTN1.67895879
24EPHA21.66905054
25LATS11.66422496
26MAP3K21.60550098
27PRKD31.58977824
28MAP4K11.55964107
29ICK1.52972851
30MAP3K111.52448076
31PRKG21.51073491
32STK391.47877109
33FER1.44840189
34LRRK21.40414159
35STK101.35878199
36PDGFRA1.35388440
37DMPK1.32850700
38CDC42BPA1.28369031
39PRPF4B1.19486657
40BLK1.17208488
41GRK61.16040689
42TAOK31.14041447
43PAK41.11560577
44OXSR11.09112774
45PTK2B1.08602666
46NME11.07032507
47DDR21.06812849
48MAP2K20.96387834
49MET0.96289293
50MAP3K30.96158320
51PDPK10.95046441
52MAP2K60.92600127
53MAP3K70.92540838
54FGFR40.89506309
55WNK30.89221497
56PTK20.86337001
57MAP3K100.85469953
58SIK10.83005322
59IRAK30.82740020
60RPS6KA20.79410180
61KDR0.78633219
62TNIK0.76279826
63EEF2K0.75675653
64GRK10.75663552
65CAMK1G0.73496580
66STK380.73364553
67PKN20.71416417
68ABL20.70940713
69CSK0.70802057
70BMX0.70800480
71DAPK20.70337986
72NUAK10.69293787
73ERBB20.67111700
74BCKDK0.66430506
75ADRBK20.66325441
76ZAP700.65977347
77CAMK1D0.65794721
78MAP3K140.64251701
79MAPK110.63937858
80PDGFRB0.63844945
81JAK30.63773073
82PDK10.63741316
83EPHA40.63532191
84PRKD10.63072080
85CSF1R0.62314173
86PHKG10.62104013
87PHKG20.62104013
88MAPKAPK30.61350179
89TAOK10.61030321
90MATK0.59749273
91PRKAA20.59411189
92KSR20.58386206
93PRKACG0.58339564
94FGFR20.56857117
95TGFBR10.56215167
96PAK20.53111083
97WNK10.53098289
98MAP3K10.52923879
99PLK40.52877235
100ROCK10.52201333
101PRKCZ0.51055749
102FGFR30.51039181
103PRKCA0.50886154
104MAP2K30.50226475
105STK30.49557165
106GRK70.49108645
107DYRK1B0.48726260
108GSK3A0.48215426
109MAPK150.47930900
110PRKAA10.47784921
111TBK10.47478403
112RET0.46562266
113KIT0.45020711
114ITK0.44761943
115NLK0.44224382
116IRAK10.42552844
117RPS6KL10.42366085
118RPS6KC10.42366085
119MAP3K120.41726295
120SYK0.41429855
121STK38L0.41379424
122JAK10.40396158
123IKBKE0.40348928
124PIK3CA0.40101542
125PIK3CG0.39759406
126PRKCH0.38828377
127INSRR0.37961281
128TYRO30.37543903
129FYN0.37344797
130PIM20.37183160
131JAK20.37161347
132SCYL20.35922588
133RPS6KA60.35763588
134EPHA30.35433351
135TYK20.34619981
136NEK60.34572340
137MAPK70.34500886
138PIM10.34004490
139SGK30.33585507
140LYN0.33493993
141MTOR0.32053591
142PRKCD0.31472976
143CAMK2D0.31459649
144PAK30.31409827
145SRC0.30716854
146BTK0.29868934
147EGFR0.29792219
148CAMK2G0.29225721
149LCK0.28901665

Predicted pathways (KEGG)

RankGene SetZ-score
1Fat digestion and absorption_Homo sapiens_hsa049753.88018655
2Vitamin digestion and absorption_Homo sapiens_hsa049772.95199758
3Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.89885284
4Mineral absorption_Homo sapiens_hsa049782.86853663
5* Renin-angiotensin system_Homo sapiens_hsa046142.64209633
6Protein digestion and absorption_Homo sapiens_hsa049742.56051318
7Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.53183517
8Caffeine metabolism_Homo sapiens_hsa002322.51669307
9Carbohydrate digestion and absorption_Homo sapiens_hsa049732.40700008
10Starch and sucrose metabolism_Homo sapiens_hsa005002.00161423
11Galactose metabolism_Homo sapiens_hsa000521.93319493
12Bile secretion_Homo sapiens_hsa049761.88974589
13Linoleic acid metabolism_Homo sapiens_hsa005911.78766437
14PPAR signaling pathway_Homo sapiens_hsa033201.77540647
15Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.63425828
162-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.63168896
17Fatty acid degradation_Homo sapiens_hsa000711.62686027
18alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.58529352
19Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.57779016
20Chemical carcinogenesis_Homo sapiens_hsa052041.51688441
21Sulfur metabolism_Homo sapiens_hsa009201.48656764
22Asthma_Homo sapiens_hsa053101.48654432
23Retinol metabolism_Homo sapiens_hsa008301.47265902
24Drug metabolism - other enzymes_Homo sapiens_hsa009831.38928470
25Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.36331291
26Fructose and mannose metabolism_Homo sapiens_hsa000511.36233193
27Arachidonic acid metabolism_Homo sapiens_hsa005901.34872225
28Tryptophan metabolism_Homo sapiens_hsa003801.34646651
29Allograft rejection_Homo sapiens_hsa053301.33692996
30Intestinal immune network for IgA production_Homo sapiens_hsa046721.30407551
31Glycerolipid metabolism_Homo sapiens_hsa005611.30038633
32Propanoate metabolism_Homo sapiens_hsa006401.25965788
33Fatty acid biosynthesis_Homo sapiens_hsa000611.23253938
34Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.22876388
35Autoimmune thyroid disease_Homo sapiens_hsa053201.20220023
36Staphylococcus aureus infection_Homo sapiens_hsa051501.19332161
37ECM-receptor interaction_Homo sapiens_hsa045121.19216120
38Pyruvate metabolism_Homo sapiens_hsa006201.17837524
39Graft-versus-host disease_Homo sapiens_hsa053321.16031390
40Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.12287655
41Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.08959773
42Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.08266261
43Fatty acid metabolism_Homo sapiens_hsa012121.04882019
44Steroid hormone biosynthesis_Homo sapiens_hsa001401.04255094
45Tight junction_Homo sapiens_hsa045301.04080762
46Adherens junction_Homo sapiens_hsa045200.97861999
47Thyroid hormone synthesis_Homo sapiens_hsa049180.97738953
48Arginine biosynthesis_Homo sapiens_hsa002200.97559594
49Phenylalanine metabolism_Homo sapiens_hsa003600.95030391
50Type I diabetes mellitus_Homo sapiens_hsa049400.93517326
51Glutathione metabolism_Homo sapiens_hsa004800.93275868
52Nitrogen metabolism_Homo sapiens_hsa009100.92816817
53Ether lipid metabolism_Homo sapiens_hsa005650.92472717
54Sphingolipid metabolism_Homo sapiens_hsa006000.92103998
55Cyanoamino acid metabolism_Homo sapiens_hsa004600.92039345
56Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.91270534
57Focal adhesion_Homo sapiens_hsa045100.90382484
58Leukocyte transendothelial migration_Homo sapiens_hsa046700.90218062
59Pentose and glucuronate interconversions_Homo sapiens_hsa000400.88678137
60Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.85634959
61Histidine metabolism_Homo sapiens_hsa003400.85375716
62Gastric acid secretion_Homo sapiens_hsa049710.84399903
63Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.79670254
64Carbon metabolism_Homo sapiens_hsa012000.78767603
65ABC transporters_Homo sapiens_hsa020100.77819543
66Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.72196288
67Insulin resistance_Homo sapiens_hsa049310.71875021
68Maturity onset diabetes of the young_Homo sapiens_hsa049500.70637915
69Antigen processing and presentation_Homo sapiens_hsa046120.70556677
70Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.70445140
71Amoebiasis_Homo sapiens_hsa051460.69560268
72Folate biosynthesis_Homo sapiens_hsa007900.68290522
73Leishmaniasis_Homo sapiens_hsa051400.67753557
74Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.67393180
75Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.65814780
76Arginine and proline metabolism_Homo sapiens_hsa003300.65688027
77beta-Alanine metabolism_Homo sapiens_hsa004100.65633378
78AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.64002387
79Dorso-ventral axis formation_Homo sapiens_hsa043200.63862807
80Adipocytokine signaling pathway_Homo sapiens_hsa049200.63627309
81Dilated cardiomyopathy_Homo sapiens_hsa054140.61584472
82Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.56154663
83Lysine degradation_Homo sapiens_hsa003100.55570270
84Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.54746785
85Other glycan degradation_Homo sapiens_hsa005110.54741075
86Pancreatic secretion_Homo sapiens_hsa049720.53936562
87Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.52931220
88Salivary secretion_Homo sapiens_hsa049700.52896190
89Bladder cancer_Homo sapiens_hsa052190.52684002
90Pertussis_Homo sapiens_hsa051330.50633421
91Type II diabetes mellitus_Homo sapiens_hsa049300.50106977
92Viral myocarditis_Homo sapiens_hsa054160.47632019
93Vascular smooth muscle contraction_Homo sapiens_hsa042700.47596947
94Pentose phosphate pathway_Homo sapiens_hsa000300.46688648
95* Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.46600866
96Butanoate metabolism_Homo sapiens_hsa006500.46333153
97* Renin secretion_Homo sapiens_hsa049240.46317697
98cGMP-PKG signaling pathway_Homo sapiens_hsa040220.45020935
99Peroxisome_Homo sapiens_hsa041460.44458217
100Selenocompound metabolism_Homo sapiens_hsa004500.42828543
101Hematopoietic cell lineage_Homo sapiens_hsa046400.42561726
102Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.41826620
103Glycerophospholipid metabolism_Homo sapiens_hsa005640.41548337
104Vibrio cholerae infection_Homo sapiens_hsa051100.41528642
105Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.40938862
106Tuberculosis_Homo sapiens_hsa051520.39756933
107Lysosome_Homo sapiens_hsa041420.39500041
108AMPK signaling pathway_Homo sapiens_hsa041520.38792565
109Primary bile acid biosynthesis_Homo sapiens_hsa001200.38508947
110Toxoplasmosis_Homo sapiens_hsa051450.38056985
111Glycosaminoglycan degradation_Homo sapiens_hsa005310.37720258
112Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.37492746
113Small cell lung cancer_Homo sapiens_hsa052220.37105729
114VEGF signaling pathway_Homo sapiens_hsa043700.35925414
115Salmonella infection_Homo sapiens_hsa051320.35715472
116Estrogen signaling pathway_Homo sapiens_hsa049150.35661770
117Rheumatoid arthritis_Homo sapiens_hsa053230.34604165
118Endocytosis_Homo sapiens_hsa041440.34482433
119Inositol phosphate metabolism_Homo sapiens_hsa005620.34331047
120Proteoglycans in cancer_Homo sapiens_hsa052050.32034760
121Tyrosine metabolism_Homo sapiens_hsa003500.31683393
122Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.31682669
123Regulation of actin cytoskeleton_Homo sapiens_hsa048100.31585911
124Central carbon metabolism in cancer_Homo sapiens_hsa052300.31115816
125Gap junction_Homo sapiens_hsa045400.30075952
126Hepatitis C_Homo sapiens_hsa051600.29754511
127Insulin secretion_Homo sapiens_hsa049110.28702158
128Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.28382834
129Platelet activation_Homo sapiens_hsa046110.28188211
130Cocaine addiction_Homo sapiens_hsa050300.26264330
131Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.25020092
132TNF signaling pathway_Homo sapiens_hsa046680.24676862
133Influenza A_Homo sapiens_hsa051640.22969170
134* Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.22169967
135Phagosome_Homo sapiens_hsa041450.20293067
136Chemokine signaling pathway_Homo sapiens_hsa040620.20126093
137Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.19290385
138Glucagon signaling pathway_Homo sapiens_hsa049220.19208983
139Aldosterone synthesis and secretion_Homo sapiens_hsa049250.19152693
140Sulfur relay system_Homo sapiens_hsa041220.18643021
141African trypanosomiasis_Homo sapiens_hsa051430.18411610
142Osteoclast differentiation_Homo sapiens_hsa043800.16705517
143GnRH signaling pathway_Homo sapiens_hsa049120.13245240
144Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.10749378

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