ACE2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. The organ- and cell-specific expression of this gene suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronaviruses SARS and HCoV-NL63. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* angiotensin maturation (GO:0002003)9.18719947
2regulation of guanylate cyclase activity (GO:0031282)7.83787959
3epoxygenase P450 pathway (GO:0019373)7.30612644
4vitamin A metabolic process (GO:0006776)7.26624269
5fat-soluble vitamin biosynthetic process (GO:0042362)6.93596415
6positive regulation of guanylate cyclase activity (GO:0031284)6.12654026
7fructose metabolic process (GO:0006000)5.98294458
8phospholipid efflux (GO:0033700)5.94976562
9triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.62920183
10drug catabolic process (GO:0042737)5.43250680
11regulation of cholesterol esterification (GO:0010872)5.36977830
12peptide catabolic process (GO:0043171)5.36889023
13digestive system process (GO:0022600)5.34982754
14modified amino acid transport (GO:0072337)5.32687939
15flavonoid metabolic process (GO:0009812)5.31393413
16drug metabolic process (GO:0017144)5.28762894
17actin filament depolymerization (GO:0030042)5.26245478
18positive regulation of lipoprotein lipase activity (GO:0051006)5.23088917
19positive regulation of triglyceride lipase activity (GO:0061365)5.23088917
20cellular glucuronidation (GO:0052695)5.07949134
21regulation of triglyceride catabolic process (GO:0010896)5.03705413
22digestion (GO:0007586)5.03135950
23regulation of cellular extravasation (GO:0002691)5.02483642
24plasma lipoprotein particle assembly (GO:0034377)5.01145692
25uronic acid metabolic process (GO:0006063)4.99325814
26glucuronate metabolic process (GO:0019585)4.99325814
27hormone catabolic process (GO:0042447)4.97018784
28urea cycle (GO:0000050)4.83273524
29receptor guanylyl cyclase signaling pathway (GO:0007168)4.79841653
30lipoprotein metabolic process (GO:0042157)4.77456742
31regulation of cGMP biosynthetic process (GO:0030826)4.77010184
32protein-lipid complex assembly (GO:0065005)4.74847069
33cholesterol efflux (GO:0033344)4.71288997
343-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)4.66783154
35purine ribonucleoside bisphosphate metabolic process (GO:0034035)4.66783154
36urea metabolic process (GO:0019627)4.63945191
37* peptide hormone processing (GO:0016486)4.60149427
38cellular response to hepatocyte growth factor stimulus (GO:0035729)4.54423911
39response to hepatocyte growth factor (GO:0035728)4.54423911
40* regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)4.50167989
41bundle of His cell to Purkinje myocyte communication (GO:0086069)4.43751864
42regulation of bile acid biosynthetic process (GO:0070857)4.42827224
43glucose 6-phosphate metabolic process (GO:0051156)4.33695158
44renal system process involved in regulation of blood volume (GO:0001977)4.32051181
45glycolipid catabolic process (GO:0019377)4.31429153
46glycosphingolipid catabolic process (GO:0046479)4.27802369
47nitrogen cycle metabolic process (GO:0071941)4.27085053
48diacylglycerol metabolic process (GO:0046339)4.24101913
49purine nucleotide salvage (GO:0032261)4.22490517
50cellular response to nitric oxide (GO:0071732)4.16082265
51vitamin transmembrane transport (GO:0035461)4.13713512
52negative regulation of digestive system process (GO:0060457)4.09821046
53homocysteine metabolic process (GO:0050667)4.09424615
54regulation of vitamin metabolic process (GO:0030656)4.07974042
55cholesterol transport (GO:0030301)4.06714913
56sterol transport (GO:0015918)4.06714913
57very-low-density lipoprotein particle assembly (GO:0034379)4.03126683
58* regulation of systemic arterial blood pressure (GO:0003073)4.02010979
59positive regulation of fatty acid biosynthetic process (GO:0045723)3.97054988
60regulation of cGMP metabolic process (GO:0030823)3.95324064
61thyroid hormone metabolic process (GO:0042403)3.94439724
62fat-soluble vitamin metabolic process (GO:0006775)3.93128233
63antibacterial humoral response (GO:0019731)3.92904655
64reverse cholesterol transport (GO:0043691)3.92784683
65vitamin transport (GO:0051180)3.91528559
66alkaloid metabolic process (GO:0009820)3.90892644
67cholesterol homeostasis (GO:0042632)3.83671668
68lipoprotein transport (GO:0042953)3.83131410
69sterol homeostasis (GO:0055092)3.81040041
70antimicrobial humoral response (GO:0019730)3.80249725
71regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.75564707
72negative regulation of sterol transport (GO:0032372)3.75504224
73negative regulation of cholesterol transport (GO:0032375)3.75504224
74desmosome organization (GO:0002934)3.74188542
75fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.67682858
76positive regulation of glycoprotein biosynthetic process (GO:0010560)3.65710272
77glutamine family amino acid biosynthetic process (GO:0009084)3.65334974
78UDP-N-acetylglucosamine metabolic process (GO:0006047)3.64080151
79bile acid metabolic process (GO:0008206)3.61320971
80L-alpha-amino acid transmembrane transport (GO:1902475)3.59522190
81cGMP biosynthetic process (GO:0006182)3.59312464
82exogenous drug catabolic process (GO:0042738)3.59259246
83response to nitric oxide (GO:0071731)3.56676713
84positive regulation of cGMP biosynthetic process (GO:0030828)3.55385127
85cellular response to reactive nitrogen species (GO:1902170)3.54680526
86sphingomyelin metabolic process (GO:0006684)3.52890574
87regulation of digestive system process (GO:0044058)3.52182071
88sulfate transmembrane transport (GO:1902358)3.51748668
89oligosaccharide catabolic process (GO:0009313)3.51684870
90sulfur compound transport (GO:0072348)3.50322372
91regulation of cholesterol homeostasis (GO:2000188)3.48358520
92transcytosis (GO:0045056)3.48304316
93midgut development (GO:0007494)3.47536432
94high-density lipoprotein particle remodeling (GO:0034375)3.46225125
95regulation of penile erection (GO:0060405)3.45416361
96ceramide catabolic process (GO:0046514)3.44927010
97positive regulation of pseudopodium assembly (GO:0031274)3.44709232
98vitamin biosynthetic process (GO:0009110)3.44357729
99arginine metabolic process (GO:0006525)3.43800739
100response to hydroperoxide (GO:0033194)3.43800433
101mRNA modification (GO:0016556)3.42867293
102glycosylceramide metabolic process (GO:0006677)3.41781702
103vitamin D metabolic process (GO:0042359)3.37280983
104drug transport (GO:0015893)3.35026378
105cobalamin metabolic process (GO:0009235)3.34778961
106cGMP-mediated signaling (GO:0019934)3.31992809
107COPI coating of Golgi vesicle (GO:0048205)3.31683926
108Golgi transport vesicle coating (GO:0048200)3.31683926
109transepithelial transport (GO:0070633)3.31430279
110positive regulation of triglyceride metabolic process (GO:0090208)3.30599397
111regulation of lipoprotein metabolic process (GO:0050746)3.30050932
112positive regulation of glycoprotein metabolic process (GO:1903020)3.29816600
113COPII vesicle coating (GO:0048208)3.27107088
114phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.26552210
115sphingolipid catabolic process (GO:0030149)3.24316044
116nucleoside diphosphate biosynthetic process (GO:0009133)3.22813083
117protein-lipid complex remodeling (GO:0034368)3.22657944
118macromolecular complex remodeling (GO:0034367)3.22657944
119plasma lipoprotein particle remodeling (GO:0034369)3.22657944
120urate metabolic process (GO:0046415)3.21496480
121citrulline biosynthetic process (GO:0019240)3.20337700
122sexual reproduction (GO:0019953)3.20026065
123response to phenylpropanoid (GO:0080184)3.19473463
124sulfation (GO:0051923)3.17183657
125renal absorption (GO:0070293)3.16173941
126drug transmembrane transport (GO:0006855)3.14967764
127bile acid and bile salt transport (GO:0015721)3.13838069
128glomerulus development (GO:0032835)3.12881700
129plasma lipoprotein particle organization (GO:0071827)3.12267529
130neutral amino acid transport (GO:0015804)3.10894544
131membrane lipid catabolic process (GO:0046466)3.10527282
132intestinal epithelial cell development (GO:0060576)3.10321273
133NADH metabolic process (GO:0006734)3.10226784
134renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)3.10202597
135L-ascorbic acid metabolic process (GO:0019852)3.10042540
136polyol transport (GO:0015791)3.09954679
137protein-lipid complex subunit organization (GO:0071825)3.09183049
138hydrogen peroxide catabolic process (GO:0042744)3.05916617
139positive regulation of T cell differentiation in thymus (GO:0033089)3.03383457
140endocrine pancreas development (GO:0031018)2.99478591
141regulation of Golgi to plasma membrane protein transport (GO:0042996)2.98171922
142membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.93174726
143negative regulation of thymocyte apoptotic process (GO:0070244)2.89934631
144cellular carbohydrate catabolic process (GO:0044275)2.88778087
145bicarbonate transport (GO:0015701)2.88247999
146regulation of cholesterol transport (GO:0032374)2.88085324
147regulation of sterol transport (GO:0032371)2.88085324
148positive regulation of lipid catabolic process (GO:0050996)2.87461284
149nucleotide salvage (GO:0043173)2.86493609
150beta-amyloid metabolic process (GO:0050435)2.85941723
151glycerol metabolic process (GO:0006071)2.85187452
152* regulation of systemic arterial blood pressure by hormone (GO:0001990)2.83835608
153* regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)2.83835608
154* endocrine process (GO:0050886)2.83835608
155innate immune response in mucosa (GO:0002227)2.79713487
156maintenance of gastrointestinal epithelium (GO:0030277)2.79135065
157intestinal absorption (GO:0050892)12.6701750
158intestinal cholesterol absorption (GO:0030299)12.3497494

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human9.76755514
2CDX2_20551321_ChIP-Seq_CACO-2_Human4.38610275
3SOX2_27498859_Chip-Seq_STOMACH_Mouse3.27085700
4BP1_19119308_ChIP-ChIP_Hs578T_Human3.16284913
5ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.84391953
6GATA4_25053715_ChIP-Seq_YYC3_Human2.80309218
7HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.61733595
8TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.52686724
9PPARA_22158963_ChIP-Seq_LIVER_Mouse2.48537283
10LXR_22158963_ChIP-Seq_LIVER_Mouse2.43809913
11SOX2_20726797_ChIP-Seq_SW620_Human2.41610324
12GATA6_25053715_ChIP-Seq_YYC3_Human2.29436573
13RXR_22158963_ChIP-Seq_LIVER_Mouse2.25688769
14IRF8_22096565_ChIP-ChIP_GC-B_Human2.04264102
15CDX2_19796622_ChIP-Seq_MESCs_Mouse1.99771107
16PPAR_26484153_Chip-Seq_NCI-H1993_Human1.86820374
17SRY_22984422_ChIP-ChIP_TESTIS_Rat1.70522240
18GATA1_22025678_ChIP-Seq_K562_Human1.64121951
19ESR2_21235772_ChIP-Seq_MCF-7_Human1.59599514
20STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.59206928
21FOXO3_23340844_ChIP-Seq_DLD1_Human1.55300944
22TCF4_18268006_ChIP-ChIP_LS174T_Human1.55029053
23TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.54147296
24KLF5_25053715_ChIP-Seq_YYC3_Human1.52948564
25BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.52551250
26RUNX1_27514584_Chip-Seq_MCF-7_Human1.46640334
27AR_21909140_ChIP-Seq_LNCAP_Human1.45199705
28ZNF217_24962896_ChIP-Seq_MCF-7_Human1.42941691
29ESR1_21235772_ChIP-Seq_MCF-7_Human1.42759309
30IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.42423871
31CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.41131520
32SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.39712105
33KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.39602388
34NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.39532714
35CLOCK_20551151_ChIP-Seq_293T_Human1.39247697
36PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.38666199
37FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.35867939
38EGR1_23403033_ChIP-Seq_LIVER_Mouse1.32500336
39ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.29068812
40KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.29030574
41ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.26051938
42CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.25158773
43FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.24275401
44BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.23481753
45RACK7_27058665_Chip-Seq_MCF-7_Human1.17567795
46PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.17096649
47FOXA2_19822575_ChIP-Seq_HepG2_Human1.16740750
48MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.15909209
49* GATA2_19941826_ChIP-Seq_K562_Human1.15841672
50* HNF4A_19822575_ChIP-Seq_HepG2_Human1.15234527
51ATF3_27146783_Chip-Seq_COLON_Human1.13954597
52ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.13576449
53HIF1A_21447827_ChIP-Seq_MCF-7_Human1.12952090
54RXR_22108803_ChIP-Seq_LS180_Human1.12633439
55IRF8_21731497_ChIP-ChIP_J774_Mouse1.12348217
56AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.11484646
57NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.10827697
58SOX9_24532713_ChIP-Seq_HFSC_Mouse1.10631300
59STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.09510632
60P63_26484246_Chip-Seq_KERATINOCYTES_Human1.08482491
61FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.08297197
62STAT6_21828071_ChIP-Seq_BEAS2B_Human1.07718440
63SALL4_18804426_ChIP-ChIP_XEN_Mouse1.06692633
64TP63_23658742_ChIP-Seq_EP156T_Human1.06250273
65CREB1_26743006_Chip-Seq_LNCaP_Human1.06135238
66VDR_22108803_ChIP-Seq_LS180_Human1.06074289
67ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.04898317
68FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.03657353
69* TRIM28_21343339_ChIP-Seq_HEK293_Human1.02506300
70RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.01437653
71TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.95942159
72VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.95818826
73ZNF263_19887448_ChIP-Seq_K562_Human0.95328327
74BCOR_27268052_Chip-Seq_Bcells_Human0.94976091
75JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.94659456
76GATA3_24758297_ChIP-Seq_MCF-7_Human0.93829544
77TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.92828831
78LXR_22292898_ChIP-Seq_THP-1_Human0.92674687
79VDR_24787735_ChIP-Seq_THP-1_Human0.92565342
80* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.91629106
81SA1_27219007_Chip-Seq_Bcells_Human0.91537298
82CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.89273228
83EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.89117026
84BCL6_27268052_Chip-Seq_Bcells_Human0.88537377
85CEBPB_22108803_ChIP-Seq_LS180_Human0.88080865
86SMAD3_21741376_ChIP-Seq_HESCs_Human0.87488031
87SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.87217893
88FOXA1_25552417_ChIP-Seq_VCAP_Human0.87149872
89GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86889604
90GATA2_22383799_ChIP-Seq_G1ME_Mouse0.86657531
91RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.86261153
92Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.85636538
93TP63_22573176_ChIP-Seq_HFKS_Human0.85153863
94PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.83942999
95TET1_21451524_ChIP-Seq_MESCs_Mouse0.83892813
96CTNNB1_20460455_ChIP-Seq_HCT116_Human0.81994300
97SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.81883247
98CTCF_27219007_Chip-Seq_Bcells_Human0.81600837
99GATA2_21666600_ChIP-Seq_HMVEC_Human0.81433978
100EGR1_19032775_ChIP-ChIP_M12_Human0.81032416
101SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.81022561
102SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.81022561
103TCF3_18692474_ChIP-Seq_MEFs_Mouse0.80828579
104FOXA1_21572438_ChIP-Seq_LNCaP_Human0.80258513
105CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.78143414
106BCAT_22108803_ChIP-Seq_LS180_Human0.77806941
107SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.77779060
108KAP1_22055183_ChIP-Seq_ESCs_Mouse0.77430571
109ESR1_20079471_ChIP-ChIP_T-47D_Human0.77027616
110JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.76949995
111SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.76710709
112GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.75721631
113NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.75605700
114* GATA1_19941826_ChIP-Seq_K562_Human0.75233577
115CJUN_26792858_Chip-Seq_BT549_Human0.75083848
116PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.74832702
117PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.73990583
118GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.73829843
119RAD21_21589869_ChIP-Seq_MESCs_Mouse0.72749325
120FOXM1_26456572_ChIP-Seq_MCF-7_Human0.72360553
121GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.71702407
122NR3C1_21868756_ChIP-Seq_MCF10A_Human0.71662463
123CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.71368986
124THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.71243195
125CDX2_22108803_ChIP-Seq_LS180_Human0.70549442
126JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.70152609
127NANOG_20526341_ChIP-Seq_ESCs_Human0.70081881
128EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.69735655
129ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.67066307
130SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.66879734

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis9.81715529
2MP0001666_abnormal_nutrient_absorption6.01819627
3MP0010234_abnormal_vibrissa_follicle4.47079639
4MP0009840_abnormal_foam_cell4.27082119
5MP0002139_abnormal_hepatobiliary_system3.50134201
6MP0004264_abnormal_extraembryonic_tissu3.47984335
7MP0003252_abnormal_bile_duct3.36714802
8MP0005085_abnormal_gallbladder_physiolo2.91742742
9MP0008875_abnormal_xenobiotic_pharmacok2.77715220
10MP0010329_abnormal_lipoprotein_level2.59878632
11MP0000462_abnormal_digestive_system2.57799285
12MP0005084_abnormal_gallbladder_morpholo2.51441824
13MP0002796_impaired_skin_barrier2.49429187
14MP0004043_abnormal_pH_regulation2.45103563
15MP0004019_abnormal_vitamin_homeostasis2.40847952
16MP0003866_abnormal_defecation2.21121360
17MP0003868_abnormal_feces_composition2.08486448
18MP0004147_increased_porphyrin_level2.06095230
19MP0005365_abnormal_bile_salt1.97850572
20MP0000538_abnormal_urinary_bladder1.86413646
21MP0003300_gastrointestinal_ulcer1.68227782
22MP0003878_abnormal_ear_physiology1.64518114
23MP0005377_hearing/vestibular/ear_phenot1.64518114
24MP0005670_abnormal_white_adipose1.64440394
25MP0002822_catalepsy1.63847574
26MP0006054_spinal_hemorrhage1.58832535
27MP0002254_reproductive_system_inflammat1.55356143
28MP0005448_abnormal_energy_balance1.51843307
29MP0009697_abnormal_copulation1.50217936
30MP0003191_abnormal_cellular_cholesterol1.48232485
31MP0001664_abnormal_digestion1.46653357
32MP0005501_abnormal_skin_physiology1.46136367
33MP0005166_decreased_susceptibility_to1.43330785
34MP0009643_abnormal_urine_homeostasis1.42079853
35MP0000537_abnormal_urethra_morphology1.38862135
36MP0005332_abnormal_amino_acid1.38070186
37MP0003705_abnormal_hypodermis_morpholog1.34910803
38MP0001188_hyperpigmentation1.31922584
39MP0010352_gastrointestinal_tract_polyps1.28451001
40MP0005381_digestive/alimentary_phenotyp1.26800781
41MP0002098_abnormal_vibrissa_morphology1.26469414
42MP0000013_abnormal_adipose_tissue1.23787689
43MP0009780_abnormal_chondrocyte_physiolo1.23177690
44MP0009379_abnormal_foot_pigmentation1.23138769
45MP0004947_skin_inflammation1.22069583
46MP0001765_abnormal_ion_homeostasis1.21153125
47MP0010678_abnormal_skin_adnexa1.19816794
48MP0004270_analgesia1.18217211
49MP0001663_abnormal_digestive_system1.17619642
50MP0002876_abnormal_thyroid_physiology1.14647245
51MP0000477_abnormal_intestine_morphology1.14084065
52MP0005451_abnormal_body_composition1.13741233
53MP0002089_abnormal_postnatal_growth/wei1.13653148
54MP0002118_abnormal_lipid_homeostasis1.11946458
55MP0001501_abnormal_sleep_pattern1.11444014
56MP0010155_abnormal_intestine_physiology1.10836972
57MP0004782_abnormal_surfactant_physiolog1.10805448
58MP0000467_abnormal_esophagus_morphology1.07635649
59MP0000678_abnormal_parathyroid_gland1.02974610
60MP0004858_abnormal_nervous_system1.02888059
61MP0003283_abnormal_digestive_organ1.02123019
62MP0005535_abnormal_body_temperature1.00639679
63MP0005584_abnormal_enzyme/coenzyme_acti0.96906496
64MP0001216_abnormal_epidermal_layer0.94241834
65MP0000609_abnormal_liver_physiology0.93141321
66MP0001873_stomach_inflammation0.92617953
67MP0005636_abnormal_mineral_homeostasis0.92262886
68MP0002971_abnormal_brown_adipose0.92249768
69MP0002396_abnormal_hematopoietic_system0.89461778
70MP0003453_abnormal_keratinocyte_physiol0.88466147
71MP0003941_abnormal_skin_development0.86025893
72MP0005367_renal/urinary_system_phenotyp0.85631422
73MP0000516_abnormal_urinary_system0.85631422
74MP0003806_abnormal_nucleotide_metabolis0.85480578
75MP0000003_abnormal_adipose_tissue0.84308590
76MP0001845_abnormal_inflammatory_respons0.79062580
77MP0001849_ear_inflammation0.78268137
78MP0010386_abnormal_urinary_bladder0.77728959
79MP0001756_abnormal_urination0.77437277
80MP0002136_abnormal_kidney_physiology0.76524614
81MP0005167_abnormal_blood-brain_barrier0.75480885
82MP0000490_abnormal_crypts_of0.74949579
83MP0002877_abnormal_melanocyte_morpholog0.74559254
84MP0003638_abnormal_response/metabolism_0.70612536
85MP0002909_abnormal_adrenal_gland0.70223681
86MP0002078_abnormal_glucose_homeostasis0.70211143
87MP0005666_abnormal_adipose_tissue0.69967360
88MP0000427_abnormal_hair_cycle0.69089964
89MP0003718_maternal_effect0.65891502
90MP0001485_abnormal_pinna_reflex0.64374837
91MP0000377_abnormal_hair_follicle0.63892749
92MP0001191_abnormal_skin_condition0.63773607
93MP0000465_gastrointestinal_hemorrhage0.63429606
94MP0003879_abnormal_hair_cell0.62399680
95MP0009785_altered_susceptibility_to0.62220902
96MP0002693_abnormal_pancreas_physiology0.61792327
97MP0010771_integument_phenotype0.60893354
98MP0000579_abnormal_nail_morphology0.60107539
99MP0008004_abnormal_stomach_pH0.60026274
100* MP0008469_abnormal_protein_level0.59912458
101MP0005266_abnormal_metabolism0.59901861
102* MP0000230_abnormal_systemic_arterial0.58713275
103* MP0009642_abnormal_blood_homeostasis0.57781882
104MP0002060_abnormal_skin_morphology0.57674200
105MP0008872_abnormal_physiological_respon0.57615580
106MP0000249_abnormal_blood_vessel0.57239661
107MP0002166_altered_tumor_susceptibility0.56929868
108MP0008961_abnormal_basal_metabolism0.55117907
109MP0005334_abnormal_fat_pad0.54961585
110MP0003724_increased_susceptibility_to0.54792350
111MP0005319_abnormal_enzyme/_coenzyme0.54178801
112MP0002138_abnormal_hepatobiliary_system0.53111453
113MP0000604_amyloidosis0.53002530
114MP0005379_endocrine/exocrine_gland_phen0.52627162
115MP0005409_darkened_coat_color0.52546198
116MP0005395_other_phenotype0.51997632
117MP0009384_cardiac_valve_regurgitation0.51960453
118MP0001881_abnormal_mammary_gland0.51021920
119MP0005275_abnormal_skin_tensile0.50959594
120MP0003953_abnormal_hormone_level0.50826123
121MP0002896_abnormal_bone_mineralization0.50552559
122* MP0003183_abnormal_peptide_metabolism0.50311882
123MP0005174_abnormal_tail_pigmentation0.49948806
124MP0002009_preneoplasia0.49733586
125MP0009764_decreased_sensitivity_to0.49328398
126MP0001764_abnormal_homeostasis0.49289063
127MP0005375_adipose_tissue_phenotype0.49208477
128MP0001944_abnormal_pancreas_morphology0.48694263
129MP0000566_synostosis0.47776571
130MP0004484_altered_response_of0.47333956
131MP0000613_abnormal_salivary_gland0.46297853
132MP0009115_abnormal_fat_cell0.44451826
133MP0008260_abnormal_autophagy0.44018569
134MP0008775_abnormal_heart_ventricle0.43757297
135MP0005025_abnormal_response_to0.43194257
136MP0006082_CNS_inflammation0.42445667
137MP0000015_abnormal_ear_pigmentation0.40798352
138MP0003329_amyloid_beta_deposits0.40677482
139MP0005376_homeostasis/metabolism_phenot0.39908468

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glutamine family amino acid metabolism (HP:0010902)7.34938784
2Ileus (HP:0002595)7.03818089
3Acanthocytosis (HP:0001927)6.14683372
4Hypobetalipoproteinemia (HP:0003563)5.96729846
5Autoimmune thrombocytopenia (HP:0001973)5.89819630
6Abnormality of proline metabolism (HP:0010907)5.86367481
7Hydroxyprolinuria (HP:0003080)5.86367481
8Malnutrition (HP:0004395)5.06085845
9Conjugated hyperbilirubinemia (HP:0002908)4.98478871
10Increased IgE level (HP:0003212)4.90612341
11Right ventricular cardiomyopathy (HP:0011663)4.90547807
12Autoimmune hemolytic anemia (HP:0001890)4.63235248
13Cupped ribs (HP:0000887)4.30331184
14Chronic diarrhea (HP:0002028)3.97333796
15Widely patent fontanelles and sutures (HP:0004492)3.95700174
16Nausea (HP:0002018)3.93974882
17Pigmentary retinal degeneration (HP:0001146)3.84604210
18Fat malabsorption (HP:0002630)3.77335447
19Hyperglycinuria (HP:0003108)3.74617047
20Abdominal distention (HP:0003270)3.61490584
21Systemic lupus erythematosus (HP:0002725)3.58377475
22Mesangial abnormality (HP:0001966)3.55601190
23Hypolipoproteinemia (HP:0010981)3.54958061
24Glycosuria (HP:0003076)3.45636038
25Abnormality of urine glucose concentration (HP:0011016)3.45636038
26Poikilocytosis (HP:0004447)3.41884707
27Facial shape deformation (HP:0011334)3.37732372
28Potter facies (HP:0002009)3.37732372
29Increased purine levels (HP:0004368)3.16465431
30Hyperuricemia (HP:0002149)3.16465431
31Dehydration (HP:0001944)3.14126455
32Decreased circulating renin level (HP:0003351)3.10713852
33Steatorrhea (HP:0002570)3.10394059
34B lymphocytopenia (HP:0010976)3.04056550
35Abnormality of B cell number (HP:0010975)3.04056550
36Metabolic alkalosis (HP:0200114)3.03909441
37Posterior subcapsular cataract (HP:0007787)3.01831291
38Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.99757981
39Symptomatic seizures (HP:0011145)2.99310755
40Xanthomatosis (HP:0000991)2.98630877
41Nephrolithiasis (HP:0000787)2.98504557
42Alkalosis (HP:0001948)2.98430991
43Abnormal glucose tolerance (HP:0001952)2.86959122
44Woolly hair (HP:0002224)2.83170440
45Enlarged epiphyses (HP:0010580)2.74599720
46Hyperammonemia (HP:0001987)2.73798755
47Hyperparathyroidism (HP:0000843)2.73555103
48Ketoacidosis (HP:0001993)2.72705088
49Hyperphosphaturia (HP:0003109)2.71712102
50Abnormality of purine metabolism (HP:0004352)2.71565715
51Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.69925167
52Hyperinsulinemic hypoglycemia (HP:0000825)2.68675008
53Abnormality of vitamin B metabolism (HP:0004340)2.67381863
54Gastrointestinal dysmotility (HP:0002579)2.66826360
55Delayed epiphyseal ossification (HP:0002663)2.61703253
56Abnormality of renin-angiotensin system (HP:0000847)2.60425276
57Abnormality of aspartate family amino acid metabolism (HP:0010899)2.60027299
58Late onset (HP:0003584)2.59096486
59Hypoglycemic coma (HP:0001325)2.58913028
60Severe combined immunodeficiency (HP:0004430)2.53114146
61Wide cranial sutures (HP:0010537)2.47334078
62Focal segmental glomerulosclerosis (HP:0000097)2.46558192
63Hyperactive renin-angiotensin system (HP:0000841)2.46213886
64Abnormality of chloride homeostasis (HP:0011422)2.45148807
65Villous atrophy (HP:0011473)2.44333882
66Abnormality of small intestinal villus morphology (HP:0011472)2.44333882
67Abnormality of serine family amino acid metabolism (HP:0010894)2.43560611
68Abnormality of glycine metabolism (HP:0010895)2.43560611
69Abnormality of the vitamin B12 metabolism (HP:0004341)2.42733350
70Hypoglycemic seizures (HP:0002173)2.41159741
71Gout (HP:0001997)2.39435959
72Abnormality of the gastric mucosa (HP:0004295)2.37453753
73Thyroiditis (HP:0100646)2.34399232
74Mildly elevated creatine phosphokinase (HP:0008180)2.32804538
75Abnormality of monocarboxylic acid metabolism (HP:0010996)2.32467111
76Abnormality of the costochondral junction (HP:0000919)2.32417551
77Eczematoid dermatitis (HP:0000976)2.32397621
78Polycythemia (HP:0001901)2.31603533
79Progressive sensorineural hearing impairment (HP:0000408)2.31476342
80Abnormality of vitamin metabolism (HP:0100508)2.30834426
81Hypercholesterolemia (HP:0003124)2.30689015
82Abnormal urine phosphate concentration (HP:0012599)2.29030717
83Subcapsular cataract (HP:0000523)2.28267255
84Abnormality of sulfur amino acid metabolism (HP:0004339)2.27507204
85Epidermoid cyst (HP:0200040)2.25327365
86Myopathic facies (HP:0002058)2.24221211
87Intrahepatic cholestasis (HP:0001406)2.23246168
88Reticulocytosis (HP:0001923)2.22679148
89Abnormality of magnesium homeostasis (HP:0004921)2.19856961
90Renal tubular acidosis (HP:0001947)2.15982867
91Hypophosphatemia (HP:0002148)2.15218670
92Combined immunodeficiency (HP:0005387)2.15119216
93Hemorrhage of the eye (HP:0011885)2.14555451
94Pili torti (HP:0003777)2.11681894
95Goiter (HP:0000853)2.10555251
96Curly hair (HP:0002212)2.09598197
97Abnormal biliary tract morphology (HP:0012440)2.07960002
98Confusion (HP:0001289)2.06324541
99Hyperphosphatemia (HP:0002905)2.04943507
100Metabolic acidosis (HP:0001942)2.04893262
101Increased mean platelet volume (HP:0011877)2.04558138
102Cerebral palsy (HP:0100021)2.04543049
103Hypotension (HP:0002615)2.04185662
104Palpitations (HP:0001962)2.02675436
105Hyperglycemia (HP:0003074)2.02634831
106Protuberant abdomen (HP:0001538)2.02317151
107Proximal tubulopathy (HP:0000114)1.99266399
108Abnormality of nucleobase metabolism (HP:0010932)1.96356352
109Pancreatitis (HP:0001733)1.96341450
110Congenital sensorineural hearing impairment (HP:0008527)1.96112718
111Thin bony cortex (HP:0002753)1.95450153
112Milia (HP:0001056)1.94709487
113Irritability (HP:0000737)1.91532646
114Renal tubular dysfunction (HP:0000124)1.90742306
115Progressive hearing impairment (HP:0001730)1.90361786
116Gingivitis (HP:0000230)1.89694920
117Dicarboxylic aciduria (HP:0003215)1.86658251
118Abnormality of dicarboxylic acid metabolism (HP:0010995)1.86658251
119Syncope (HP:0001279)1.86411583
120Abnormality of alkaline phosphatase activity (HP:0004379)1.82523357
121Abnormal enzyme/coenzyme activity (HP:0012379)1.82235169
122Glomerulosclerosis (HP:0000096)1.81445203
123Abnormality of pyrimidine metabolism (HP:0004353)1.81176748
124Flat acetabular roof (HP:0003180)1.78623205
125Multiple lipomas (HP:0001012)1.78609902
126Growth hormone excess (HP:0000845)1.76964783
127Polygenic inheritance (HP:0010982)1.76510976
128Glomerulonephritis (HP:0000099)1.75103588
129Metaphyseal irregularity (HP:0003025)1.73176337
130Plantar hyperkeratosis (HP:0007556)1.72568958
131Exocrine pancreatic insufficiency (HP:0001738)1.71824697
132Hypophosphatemic rickets (HP:0004912)1.70405452
133Abnormal pancreas size (HP:0012094)1.70274965
134Abnormal platelet volume (HP:0011876)1.69034288
135Eosinophilia (HP:0001880)1.68378711
136Abnormality of calcium-phosphate metabolism (HP:0100530)1.68283744
137White forelock (HP:0002211)1.67936629
138Hyperbilirubinemia (HP:0002904)1.67358966
139Fragile nails (HP:0001808)1.67350114
140Patchy hypopigmentation of hair (HP:0011365)1.65629490
141Abnormality of complement system (HP:0005339)1.64415066
142Megaloblastic anemia (HP:0001889)1.63948191
143Complement deficiency (HP:0004431)1.62232031

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B8.69234355
2FRK7.30104340
3MST45.50234064
4MST1R4.26267507
5LMTK23.35407377
6STK392.90283399
7GRK62.87084456
8MAP3K22.86343626
9PRKG22.69719156
10AKT32.60643930
11EPHA22.57636645
12NME12.55550096
13PTK62.37012809
14RIPK12.25030422
15ERN12.22594353
16MAP3K101.99003616
17MAP2K21.95345324
18WNK31.90239013
19WNK41.72898233
20TNIK1.68942307
21MET1.66329136
22INSRR1.60730103
23TAOK31.56621243
24FER1.56577566
25MAP3K121.54442862
26NUAK11.49627714
27EPHB21.39098882
28TESK11.37704689
29PIK3CG1.27983310
30PTK21.23084960
31EPHB11.20611388
32MAP3K11.15289156
33PRKCI1.08024071
34MAP3K31.07910880
35EPHA41.07514262
36STK101.05533895
37KSR21.04721758
38PRPF4B1.03619480
39LATS10.95181861
40IRAK30.93485705
41MAP4K10.93231734
42TAOK10.91056082
43PIM10.88448466
44DYRK1B0.88236104
45PAK30.86092865
46MAPK150.85199813
47TESK20.83373073
48PRKD30.81620674
49PRKAA20.77807813
50EPHA30.75790066
51MAP2K60.75217787
52MAP3K70.74730962
53CDC42BPA0.73712101
54DDR20.72922422
55BMX0.71462080
56MAP3K90.70576670
57MAP2K10.69047573
58MAPKAPK30.65515205
59BMPR20.61399743
60SCYL20.61150827
61CASK0.59730921
62MAP3K110.57348346
63PRKCZ0.56947804
64ERBB20.55197389
65MAP3K80.54564804
66LRRK20.53393670
67MATK0.53191648
68PDGFRA0.51210057
69PRKAA10.50994360
70MYLK0.49708759
71NEK60.48781088
72PAK40.48711198
73FGFR40.48472173
74RIPK40.47461771
75IRAK10.45305200
76RET0.43800892
77TBK10.43004088
78YES10.42589042
79PIM20.41615550
80HIPK20.40056046
81MELK0.39467407
82PDPK10.39432170
83JAK10.39396287
84GRK10.38631648
85MAPK110.37838874
86ITK0.36521474
87FYN0.35140647
88TYK20.34723244
89MAPKAPK20.34099359
90CAMK2G0.31943623
91NLK0.31679511
92WNK10.31197295
93CDK190.30521966
94GSK3A0.30241393
95CAMK2B0.30237999
96ABL20.30002657
97PRKCA0.29771804
98OXSR10.28695471
99PRKACG0.24784203
100CDK60.24623011
101SRC0.24060738
102TEC0.23975702
103CSF1R0.23887103
104PDK20.23501822
105DMPK0.23287163
106IKBKE0.23155829
107PBK0.22201936
108PRKACA0.22119864
109ERBB40.21637373
110STK240.21454878
111CAMK2D0.21252751
112CSK0.21047210
113CSNK1A10.21018660
114IGF1R0.20753952
115ICK0.20612135
116TTK0.20554575
117JAK20.20207748
118LIMK10.19794454
119ARAF0.19571071
120SGK30.19285688
121BTK0.19105746
122PIK3CA0.19098111
123UHMK10.17641952
124PDK10.17149805
125PASK0.16856069
126ZAP700.16776447
127FGFR30.16202532
128CAMK2A0.16102180
129PRKCE0.15973943
130PRKCD0.15728035
131MAP3K50.15639105
132SYK0.15424496
133PRKG10.15090498
134PRKCQ0.15048087

Predicted pathways (KEGG)

RankGene SetZ-score
1Fat digestion and absorption_Homo sapiens_hsa049756.23897835
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005244.62140452
3Vitamin digestion and absorption_Homo sapiens_hsa049774.34896481
4Mineral absorption_Homo sapiens_hsa049784.15815936
5* Renin-angiotensin system_Homo sapiens_hsa046143.41007751
6Maturity onset diabetes of the young_Homo sapiens_hsa049503.32209644
7Carbohydrate digestion and absorption_Homo sapiens_hsa049732.94301409
8Caffeine metabolism_Homo sapiens_hsa002322.77413041
9Galactose metabolism_Homo sapiens_hsa000522.51419541
10Starch and sucrose metabolism_Homo sapiens_hsa005002.47655973
11* Protein digestion and absorption_Homo sapiens_hsa049742.32286610
12Folate biosynthesis_Homo sapiens_hsa007902.22719329
13Bile secretion_Homo sapiens_hsa049762.18797755
14Sulfur metabolism_Homo sapiens_hsa009201.98339096
15Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.98099231
16Histidine metabolism_Homo sapiens_hsa003401.71166350
17Sphingolipid metabolism_Homo sapiens_hsa006001.70027614
18Fructose and mannose metabolism_Homo sapiens_hsa000511.53769142
19Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.47078174
20PPAR signaling pathway_Homo sapiens_hsa033201.44277280
21Cyanoamino acid metabolism_Homo sapiens_hsa004601.32891381
22Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.32356446
23Glutathione metabolism_Homo sapiens_hsa004801.27492194
24Glycerolipid metabolism_Homo sapiens_hsa005611.25148198
25Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.16274730
26Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.12244742
27Tryptophan metabolism_Homo sapiens_hsa003801.11156006
28ABC transporters_Homo sapiens_hsa020101.10973913
29Thyroid hormone synthesis_Homo sapiens_hsa049181.03541531
30alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.02665807
31Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.02243194
32Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.98486014
33Arginine biosynthesis_Homo sapiens_hsa002200.96125031
34Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.91921206
35Fatty acid degradation_Homo sapiens_hsa000710.91905450
36Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.91903847
37Asthma_Homo sapiens_hsa053100.82035489
38Linoleic acid metabolism_Homo sapiens_hsa005910.81555757
39Insulin secretion_Homo sapiens_hsa049110.81270779
40Type II diabetes mellitus_Homo sapiens_hsa049300.79148739
41Arginine and proline metabolism_Homo sapiens_hsa003300.77668629
42Pentose and glucuronate interconversions_Homo sapiens_hsa000400.76925858
43Intestinal immune network for IgA production_Homo sapiens_hsa046720.76811681
44Glycerophospholipid metabolism_Homo sapiens_hsa005640.75235416
45Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.72369024
462-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.70092583
47Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.69278819
48Arachidonic acid metabolism_Homo sapiens_hsa005900.68531065
49Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.68400290
50Pancreatic secretion_Homo sapiens_hsa049720.64392462
51Nitrogen metabolism_Homo sapiens_hsa009100.58478897
52Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.56921629
53Tight junction_Homo sapiens_hsa045300.56895508
54Drug metabolism - other enzymes_Homo sapiens_hsa009830.56243954
55Allograft rejection_Homo sapiens_hsa053300.55088427
56Autoimmune thyroid disease_Homo sapiens_hsa053200.50799255
57Pyruvate metabolism_Homo sapiens_hsa006200.50181888
58Ether lipid metabolism_Homo sapiens_hsa005650.48855732
59Graft-versus-host disease_Homo sapiens_hsa053320.46210159
60Gastric acid secretion_Homo sapiens_hsa049710.43901718
61Tyrosine metabolism_Homo sapiens_hsa003500.43471751
62beta-Alanine metabolism_Homo sapiens_hsa004100.42152027
63Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.41598353
64Retinol metabolism_Homo sapiens_hsa008300.41524631
65Staphylococcus aureus infection_Homo sapiens_hsa051500.40805428
66Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.40362071
67Renin secretion_Homo sapiens_hsa049240.39587561
68Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.38807843
69Vibrio cholerae infection_Homo sapiens_hsa051100.37762214
70Peroxisome_Homo sapiens_hsa041460.37323920
71Carbon metabolism_Homo sapiens_hsa012000.35016004
72Chemical carcinogenesis_Homo sapiens_hsa052040.34652675
73Fatty acid metabolism_Homo sapiens_hsa012120.31181027
74Adipocytokine signaling pathway_Homo sapiens_hsa049200.30921148
75Type I diabetes mellitus_Homo sapiens_hsa049400.30363296
76Bladder cancer_Homo sapiens_hsa052190.29996232
77GnRH signaling pathway_Homo sapiens_hsa049120.28270253
78Pentose phosphate pathway_Homo sapiens_hsa000300.27728651
79Biosynthesis of amino acids_Homo sapiens_hsa012300.27637971
80Primary bile acid biosynthesis_Homo sapiens_hsa001200.27507488
81Butanoate metabolism_Homo sapiens_hsa006500.26988145
82Thyroid cancer_Homo sapiens_hsa052160.26949442
83Fatty acid biosynthesis_Homo sapiens_hsa000610.26537253
84Phosphatidylinositol signaling system_Homo sapiens_hsa040700.25700463
85Hepatitis C_Homo sapiens_hsa051600.22845351
86Insulin resistance_Homo sapiens_hsa049310.22090728
87Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.21906867
88Leukocyte transendothelial migration_Homo sapiens_hsa046700.21663004
89Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.21309972
90Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.20913106
91Sulfur relay system_Homo sapiens_hsa041220.20859009
92Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.20441165
93Steroid biosynthesis_Homo sapiens_hsa001000.19946836
94Selenocompound metabolism_Homo sapiens_hsa004500.19900329
95Metabolic pathways_Homo sapiens_hsa011000.19898994
96Glucagon signaling pathway_Homo sapiens_hsa049220.19819549
97Adherens junction_Homo sapiens_hsa045200.19301035
98Vascular smooth muscle contraction_Homo sapiens_hsa042700.18922372
99Salivary secretion_Homo sapiens_hsa049700.18395955
100Long-term depression_Homo sapiens_hsa047300.17030430
101Antigen processing and presentation_Homo sapiens_hsa046120.16521718
102Phenylalanine metabolism_Homo sapiens_hsa003600.16271706
103Inositol phosphate metabolism_Homo sapiens_hsa005620.14616922
104Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.14162013
105Aldosterone synthesis and secretion_Homo sapiens_hsa049250.13940067
106Lysine degradation_Homo sapiens_hsa003100.13799535
107African trypanosomiasis_Homo sapiens_hsa051430.13688581
108Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.12737570
109Propanoate metabolism_Homo sapiens_hsa006400.12267367
110Other glycan degradation_Homo sapiens_hsa005110.12066839
111Cocaine addiction_Homo sapiens_hsa050300.11684862
112Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.10913565
113Serotonergic synapse_Homo sapiens_hsa047260.10557300
114Steroid hormone biosynthesis_Homo sapiens_hsa001400.10030165
115Gap junction_Homo sapiens_hsa045400.09962480
116Leishmaniasis_Homo sapiens_hsa051400.09286896
117Sphingolipid signaling pathway_Homo sapiens_hsa040710.09005980
118Amphetamine addiction_Homo sapiens_hsa050310.07568508
119Ovarian steroidogenesis_Homo sapiens_hsa049130.07424295
120Salmonella infection_Homo sapiens_hsa051320.07184912
121VEGF signaling pathway_Homo sapiens_hsa043700.06920377
122Choline metabolism in cancer_Homo sapiens_hsa052310.06317042
123Fatty acid elongation_Homo sapiens_hsa000620.04607666
124AMPK signaling pathway_Homo sapiens_hsa041520.03836034
125Glycine, serine and threonine metabolism_Homo sapiens_hsa00260-0.0064643
126Viral myocarditis_Homo sapiens_hsa05416-0.0037527
127Pertussis_Homo sapiens_hsa05133-0.0011504

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