ACER2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The sphingolipid metabolite sphingosine-1-phosphate promotes cell proliferation and survival, whereas its precursor, sphingosine, has the opposite effect. The ceramidase ACER2 hydrolyzes very long chain ceramides to generate sphingosine (Xu et al., 2006 [PubMed 16940153]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1notochord development (GO:0030903)7.91101723
2* sphingosine metabolic process (GO:0006670)7.73637043
3surfactant homeostasis (GO:0043129)7.59599833
4thrombin receptor signaling pathway (GO:0070493)7.45650087
5negative regulation of cytosolic calcium ion concentration (GO:0051481)7.29313248
6regulation of translational termination (GO:0006449)7.28135320
7regulation of odontogenesis of dentin-containing tooth (GO:0042487)7.18054159
8regulation of meiosis I (GO:0060631)7.09514394
9* diol metabolic process (GO:0034311)6.97505210
10regulation of endothelial cell differentiation (GO:0045601)6.96385522
11piRNA metabolic process (GO:0034587)6.92550960
12protein-chromophore linkage (GO:0018298)6.71585710
13* sphingoid metabolic process (GO:0046519)6.69114989
14positive regulation of endothelial cell differentiation (GO:0045603)6.54250029
15negative regulation of cAMP-mediated signaling (GO:0043951)6.41046432
16DNA methylation involved in gamete generation (GO:0043046)6.23017619
17lipopolysaccharide biosynthetic process (GO:0009103)6.16682752
18lymph vessel development (GO:0001945)6.10459556
19lymphangiogenesis (GO:0001946)6.05173140
20chemical homeostasis within a tissue (GO:0048875)5.95933885
21blood vessel maturation (GO:0001955)5.60431462
22regulation of pigment cell differentiation (GO:0050932)5.57264803
23endothelium development (GO:0003158)5.44905270
24positive regulation of vasculogenesis (GO:2001214)5.35647182
25morphogenesis of an endothelium (GO:0003159)5.34699988
26endothelial tube morphogenesis (GO:0061154)5.34699988
27SMAD protein complex assembly (GO:0007183)5.31383014
28negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)5.31356024
29vascular endothelial growth factor signaling pathway (GO:0038084)5.30203787
30opioid receptor signaling pathway (GO:0038003)5.28574669
31positive regulation of developmental pigmentation (GO:0048087)5.26318443
32ether lipid metabolic process (GO:0046485)5.25977625
33negative regulation of calcium ion-dependent exocytosis (GO:0045955)5.23063251
34lipopolysaccharide metabolic process (GO:0008653)5.21591438
35nodal signaling pathway (GO:0038092)5.11548813
36positive regulation of cAMP-mediated signaling (GO:0043950)5.06087830
37regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)5.04342861
38regulation of vasculogenesis (GO:2001212)4.96208329
39adult feeding behavior (GO:0008343)4.88509899
40regulation of transforming growth factor beta2 production (GO:0032909)4.77183573
41retina vasculature morphogenesis in camera-type eye (GO:0061299)4.74453813
42sulfate transmembrane transport (GO:1902358)4.66637943
43behavioral response to ethanol (GO:0048149)4.63598208
44L-phenylalanine catabolic process (GO:0006559)4.57933685
45erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.57933685
46regulation of odontogenesis (GO:0042481)4.57322805
47negative regulation of cell cycle G2/M phase transition (GO:1902750)4.50051535
48endothelial cell differentiation (GO:0045446)4.43001772
49heme transport (GO:0015886)4.41992289
50adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)4.26854463
51erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.25534679
52L-phenylalanine metabolic process (GO:0006558)4.25534679
53cellular response to vascular endothelial growth factor stimulus (GO:0035924)4.24190441
54tyrosine metabolic process (GO:0006570)4.10084149
55sulfate transport (GO:0008272)4.06477243
56negative regulation of neural precursor cell proliferation (GO:2000178)4.04418025
57artery development (GO:0060840)4.01898047
58ovulation from ovarian follicle (GO:0001542)3.92747303
59endothelial cell morphogenesis (GO:0001886)3.88508827
60venous blood vessel morphogenesis (GO:0048845)3.87757391
61one-carbon compound transport (GO:0019755)3.85292949
62ribonucleoprotein complex disassembly (GO:0032988)3.80218579
63signal complex assembly (GO:0007172)3.77576476
64negative regulation of stem cell proliferation (GO:2000647)3.72441609
65embryonic process involved in female pregnancy (GO:0060136)3.70554165
66lung vasculature development (GO:0060426)3.70142547
67regulation of rhodopsin mediated signaling pathway (GO:0022400)3.68791493
68renal filtration (GO:0097205)3.68596437
69vitamin transmembrane transport (GO:0035461)3.67539556
70positive regulation of SMAD protein import into nucleus (GO:0060391)3.64653006
71bundle of His cell to Purkinje myocyte communication (GO:0086069)3.60059348
72regulation of acrosome reaction (GO:0060046)3.59679062
73positive regulation of meiosis (GO:0045836)3.59199325
74biotin metabolic process (GO:0006768)3.58431389
75wound healing, spreading of epidermal cells (GO:0035313)3.57621486
76gap junction assembly (GO:0016264)3.56456875
77negative regulation of nitric-oxide synthase activity (GO:0051001)3.56189699
78glomerular filtration (GO:0003094)3.54610643
79meiotic chromosome segregation (GO:0045132)3.51033329
80homocysteine metabolic process (GO:0050667)3.49951524
81response to nitrosative stress (GO:0051409)3.49001527
82regulation of interleukin-5 production (GO:0032674)3.48486623
83positive regulation of meiotic cell cycle (GO:0051446)3.47127953
84regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.44041985
85negative regulation of DNA biosynthetic process (GO:2000279)3.42159789
86sprouting angiogenesis (GO:0002040)3.39070798
87negative regulation of endothelial cell apoptotic process (GO:2000352)3.38851321
88cellular response to nitric oxide (GO:0071732)3.33245080
89rhodopsin mediated signaling pathway (GO:0016056)3.30171779
90DNA integration (GO:0015074)3.29905549
91response to epinephrine (GO:0071871)3.23614631
92vasculogenesis (GO:0001570)3.23352979
93regulation of keratinocyte proliferation (GO:0010837)3.23290306
94cell migration involved in sprouting angiogenesis (GO:0002042)3.21785186
95patterning of blood vessels (GO:0001569)3.21139677
96tachykinin receptor signaling pathway (GO:0007217)3.18240398
97lung lobe morphogenesis (GO:0060463)3.13706701
98urate metabolic process (GO:0046415)3.09449693
99blood vessel remodeling (GO:0001974)3.07143510
100regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.05562894
101fibroblast migration (GO:0010761)3.04052255
102glycerol metabolic process (GO:0006071)3.03012667
103endothelial cell proliferation (GO:0001935)3.02979704
104cellular response to reactive nitrogen species (GO:1902170)2.97953445
105negative regulation of protein autophosphorylation (GO:0031953)2.97907134
106xenobiotic catabolic process (GO:0042178)2.97777454
107serotonin receptor signaling pathway (GO:0007210)2.96951847
108negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)2.95741389
109protein retention in ER lumen (GO:0006621)2.93682582
110blood vessel endothelial cell migration (GO:0043534)2.91910217
111establishment of apical/basal cell polarity (GO:0035089)2.91493753
112negative regulation of platelet activation (GO:0010544)2.91163187
113vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.88569373
114regulation of cAMP-mediated signaling (GO:0043949)2.88101170
115ventricular trabecula myocardium morphogenesis (GO:0003222)2.85914802
116regulation of SMAD protein import into nucleus (GO:0060390)2.84251196
117cellular response to gamma radiation (GO:0071480)2.83471892
118basement membrane organization (GO:0071711)2.82704754
119germinal center formation (GO:0002467)2.82651814
120ganglion development (GO:0061548)2.80847607
121hippo signaling (GO:0035329)2.80235974
122iron coordination entity transport (GO:1901678)2.79432727
123flavonoid metabolic process (GO:0009812)2.79317222
124endoderm development (GO:0007492)2.78462005
125centriole replication (GO:0007099)2.76007834
126alditol metabolic process (GO:0019400)2.75640714
127gene silencing by RNA (GO:0031047)2.74063347
128negative regulation of focal adhesion assembly (GO:0051895)2.73395200
129negative regulation of cell junction assembly (GO:1901889)2.73395200
130negative regulation of adherens junction organization (GO:1903392)2.73395200
131paraxial mesoderm development (GO:0048339)2.73243613
132regulation of sequestering of triglyceride (GO:0010889)2.71269165
133response to mercury ion (GO:0046689)2.69742117
134superoxide anion generation (GO:0042554)2.69204963
135positive regulation of urine volume (GO:0035810)2.68892397
136positive regulation of digestive system process (GO:0060456)2.67836119
137heart trabecula morphogenesis (GO:0061384)2.66782390
138fatty acid transmembrane transport (GO:1902001)2.66126968
139epithelial cell-cell adhesion (GO:0090136)2.65395224
140negative regulation of endothelial cell proliferation (GO:0001937)2.65375470
141negative regulation of endothelial cell migration (GO:0010596)2.65328334
142pantothenate metabolic process (GO:0015939)2.64534609
143regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.64316957
144sympathetic nervous system development (GO:0048485)2.63943804
145SMAD protein signal transduction (GO:0060395)2.63530459
146negative regulation of cell fate specification (GO:0009996)2.63193685
147atrial cardiac muscle cell action potential (GO:0086014)2.62895693
148negative regulation of blood vessel endothelial cell migration (GO:0043537)2.62285165
149heart valve formation (GO:0003188)2.61818536
150establishment of skin barrier (GO:0061436)2.60923334
151renal absorption (GO:0070293)2.59061017
152sodium-independent organic anion transport (GO:0043252)2.58446660
153gamma-aminobutyric acid signaling pathway (GO:0007214)2.57756987
154regulation of hair follicle development (GO:0051797)2.57505051
155polyol transport (GO:0015791)2.56842543
156intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)2.56033859
157regulation of gonadotropin secretion (GO:0032276)2.55935151
158maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.55769976
159response to xenobiotic stimulus (GO:0009410)2.55643032
160glomerular basement membrane development (GO:0032836)2.54919568
161regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.54827861
162regulation of endothelial cell apoptotic process (GO:2000351)2.54432527
163cGMP-mediated signaling (GO:0019934)2.52538236
164negative regulation of keratinocyte proliferation (GO:0010839)2.52517541
165kinetochore assembly (GO:0051382)2.52376313
166regulation of glutamate receptor signaling pathway (GO:1900449)2.52209279
167positive regulation of pathway-restricted SMAD protein phosphorylation (GO:0010862)2.49507312
168transcytosis (GO:0045056)2.47682578
169negative regulation of mast cell activation (GO:0033004)2.45213463
170dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.44980211
171ovulation (GO:0030728)2.44609532
172tonic smooth muscle contraction (GO:0014820)2.41267207
173regulation of cellular extravasation (GO:0002691)2.38172073
174Notch signaling involved in heart development (GO:0061314)2.38123510
175trabecula morphogenesis (GO:0061383)2.37304887
176regulation of cardioblast differentiation (GO:0051890)2.35155739
177regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.32784166
178neuron projection extension involved in neuron projection guidance (GO:1902284)2.32178295
179axon extension involved in axon guidance (GO:0048846)2.32178295
180negative regulation of nitric oxide biosynthetic process (GO:0045019)2.32086641
181regulation of establishment or maintenance of cell polarity (GO:0032878)2.30379759
182mammary gland development (GO:0030879)2.30060405
183negative regulation of epithelial cell differentiation (GO:0030857)2.29413344
184response to nitric oxide (GO:0071731)2.28609471
185establishment of monopolar cell polarity (GO:0061162)2.26767727
186establishment or maintenance of monopolar cell polarity (GO:0061339)2.26767727
187facial nerve structural organization (GO:0021612)2.26694987
188regulation of urine volume (GO:0035809)2.25800097
189regulation of glomerular filtration (GO:0003093)2.25660841
190negative regulation of epithelial cell migration (GO:0010633)2.25408540
191regulation of nuclear cell cycle DNA replication (GO:0033262)2.24326059
192glomerular visceral epithelial cell development (GO:0072015)2.24236371
193drug metabolic process (GO:0017144)2.23961095

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.89697108
2TP63_17297297_ChIP-ChIP_HaCaT_Human4.23372206
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.06567536
4AR_21572438_ChIP-Seq_LNCaP_Human3.77957337
5KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.61314648
6KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.61314648
7KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.61314648
8CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.29562671
9SALL1_21062744_ChIP-ChIP_HESCs_Human3.27763964
10TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.06301008
11IGF1R_20145208_ChIP-Seq_DFB_Human3.03372326
12GATA2_21666600_ChIP-Seq_HMVEC_Human3.02081733
13EGR1_23403033_ChIP-Seq_LIVER_Mouse2.85046903
14NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.76628562
15GATA1_22025678_ChIP-Seq_K562_Human2.74768265
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.52848006
17GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.46361468
18SCL_19346495_ChIP-Seq_HPC-7_Human2.38906835
19EGR1_19032775_ChIP-ChIP_M12_Human2.35646537
20POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.35070802
21TRIM28_21343339_ChIP-Seq_HEK293_Human2.34051608
22NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.22975781
23ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.19545663
24E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.19496994
25TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.06057424
26POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.06057424
27VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.05094986
28FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.01668644
29ESR1_21235772_ChIP-Seq_MCF-7_Human2.01125053
30PCGF2_27294783_Chip-Seq_ESCs_Mouse2.00267055
31SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.98796178
32RXR_22158963_ChIP-Seq_LIVER_Mouse1.98765705
33ZNF217_24962896_ChIP-Seq_MCF-7_Human1.97461665
34PCGF2_27294783_Chip-Seq_NPCs_Mouse1.94076221
35CLOCK_20551151_ChIP-Seq_293T_Human1.90684523
36STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.90632230
37LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.88201275
38NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.86855030
39CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.86811290
40SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.85531144
41CTNNB1_20460455_ChIP-Seq_HCT116_Human1.84601727
42PPARA_22158963_ChIP-Seq_LIVER_Mouse1.82276332
43FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.82036859
44TCF3_18692474_ChIP-Seq_MEFs_Mouse1.80057987
45STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.77136063
46LXR_22158963_ChIP-Seq_LIVER_Mouse1.76879148
47TCF3_18692474_ChIP-Seq_MESCs_Mouse1.75996806
48FOXO3_23340844_ChIP-Seq_DLD1_Human1.73915404
49KAP1_22055183_ChIP-Seq_ESCs_Mouse1.73422076
50NFE2_27457419_Chip-Seq_LIVER_Mouse1.73243061
51NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.72879283
52RXR_22108803_ChIP-Seq_LS180_Human1.72195466
53NOTCH1_21737748_ChIP-Seq_TLL_Human1.70931752
54SOX2_18555785_ChIP-Seq_MESCs_Mouse1.68098478
55SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.66867738
56TP53_18474530_ChIP-ChIP_U2OS_Human1.66312560
57NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.66252989
58FLI1_27457419_Chip-Seq_LIVER_Mouse1.66048815
59SUZ12_27294783_Chip-Seq_NPCs_Mouse1.64583323
60ESR1_20079471_ChIP-ChIP_T-47D_Human1.60370461
61PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.59361178
62AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.54176082
63SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.53718227
64TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.52126609
65GBX2_23144817_ChIP-Seq_PC3_Human1.51867562
66* NANOG_19829295_ChIP-Seq_ESCs_Human1.51158041
67* SOX2_19829295_ChIP-Seq_ESCs_Human1.51158041
68CDX2_20551321_ChIP-Seq_CACO-2_Human1.51077526
69CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.50714273
70BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.50449555
71SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.50185759
72TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.46074121
73RARG_19884340_ChIP-ChIP_MEFs_Mouse1.45730552
74POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.41185961
75* TP63_23658742_ChIP-Seq_EP156T_Human1.40611888
76SALL4_18804426_ChIP-ChIP_XEN_Mouse1.40127920
77* TCF4_23295773_ChIP-Seq_U87_Human1.39522262
78TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.39443129
79RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.39249855
80PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.38186420
81CTBP2_25329375_ChIP-Seq_LNCAP_Human1.38147523
82BP1_19119308_ChIP-ChIP_Hs578T_Human1.37032939
83TAF15_26573619_Chip-Seq_HEK293_Human1.35435611
84STAT3_23295773_ChIP-Seq_U87_Human1.34403647
85* PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.34338648
86CDX2_22108803_ChIP-Seq_LS180_Human1.33390787
87TP63_19390658_ChIP-ChIP_HaCaT_Human1.32934436
88NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.32904738
89GATA1_19941826_ChIP-Seq_K562_Human1.32633980
90IRF1_19129219_ChIP-ChIP_H3396_Human1.30801083
91VDR_22108803_ChIP-Seq_LS180_Human1.30411380
92NANOG_18555785_ChIP-Seq_MESCs_Mouse1.28949406
93ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.26232401
94TP53_16413492_ChIP-PET_HCT116_Human1.24998495
95EZH2_27294783_Chip-Seq_NPCs_Mouse1.24555138
96TCF4_18268006_ChIP-ChIP_LS174T_Human1.24466387
97PPAR_26484153_Chip-Seq_NCI-H1993_Human1.21199114
98TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.20619634
99ER_23166858_ChIP-Seq_MCF-7_Human1.19245068
100STAT6_21828071_ChIP-Seq_BEAS2B_Human1.18938340
101* P300_19829295_ChIP-Seq_ESCs_Human1.18695096
102CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18241013
103* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.16682067
104FOXH1_21741376_ChIP-Seq_ESCs_Human1.16273662
105GATA4_25053715_ChIP-Seq_YYC3_Human1.16126318
106STAT3_18555785_ChIP-Seq_MESCs_Mouse1.14937530
107OCT4_21477851_ChIP-Seq_ESCs_Mouse1.14698295
108* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.14354420
109ARNT_22903824_ChIP-Seq_MCF-7_Human1.13518606
110STAT3_1855785_ChIP-Seq_MESCs_Mouse1.13073909
111CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.12550521
112CEBPB_22108803_ChIP-Seq_LS180_Human1.11241285
113ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.10499041
114IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.10449500
115ELK4_26923725_Chip-Seq_MESODERM_Mouse1.10008078
116GATA1_19941827_ChIP-Seq_MEL_Mouse1.09739871
117SOX2_18692474_ChIP-Seq_MEFs_Mouse1.09484726
118TDRD3_21172665_ChIP-Seq_MCF-7_Human1.07830459
119CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.06816802
120SMAD4_21741376_ChIP-Seq_HESCs_Human1.06431858
121* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse1.06335783
122CDX2_19796622_ChIP-Seq_MESCs_Mouse1.05880009
123FLI1_21867929_ChIP-Seq_TH2_Mouse1.05576155
124* GATA3_21878914_ChIP-Seq_MCF-7_Human1.05552001
125E2F7_22180533_ChIP-Seq_HELA_Human1.05169738
126* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.05164559
127SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.04868513
128GATA2_19941826_ChIP-Seq_K562_Human1.03857872
129NANOG_18692474_ChIP-Seq_MEFs_Mouse1.01923142
130ESR2_21235772_ChIP-Seq_MCF-7_Human1.01858254
131AR_19668381_ChIP-Seq_PC3_Human1.01774419
132FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.01771985
133STAT1_17558387_ChIP-Seq_HELA_Human1.01560441
134SMAD4_21799915_ChIP-Seq_A2780_Human1.01538511
135AR_21909140_ChIP-Seq_LNCAP_Human1.01112702
136AHR_22903824_ChIP-Seq_MCF-7_Human1.01098372
137ZFX_18555785_Chip-Seq_ESCs_Mouse1.00468500
138GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.00070269
139* HOXB7_26014856_ChIP-Seq_BT474_Human0.99153352
140FOXA2_19822575_ChIP-Seq_HepG2_Human0.98979592
141NANOG_18692474_ChIP-Seq_MESCs_Mouse0.98657340
142TBX3_20139965_ChIP-Seq_ESCs_Mouse0.98119513
143MYC_19079543_ChIP-ChIP_MESCs_Mouse0.97075064
144CRX_20693478_ChIP-Seq_RETINA_Mouse0.96618724
145NANOG_16518401_ChIP-PET_MESCs_Mouse0.96484872
146TBX3_20139965_ChIP-Seq_MESCs_Mouse0.96251693
147OCT4_18555785_Chip-Seq_ESCs_Mouse0.95918567
148* OCT1_27270436_Chip-Seq_PROSTATE_Human0.95542436
149CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.95536476
150TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.95113543
151RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.94286317
152SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.93739640
153JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.93626655
154TBX20_22328084_ChIP-Seq_HEART_Mouse0.93319835
155TBX20_22080862_ChIP-Seq_HEART_Mouse0.93319835
156* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.92927698
157SMAD4_21741376_ChIP-Seq_EPCs_Human0.92831033
158ZFP57_27257070_Chip-Seq_ESCs_Mouse0.92179053
159MYC_18555785_ChIP-Seq_MESCs_Mouse0.91585273
160PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.91521802
161PIAS1_25552417_ChIP-Seq_VCAP_Human0.89881132
162SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.89042614
163SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.89042614
164SMAD3_21741376_ChIP-Seq_HESCs_Human0.89013203
165CJUN_26792858_Chip-Seq_BT549_Human0.87810994
166STAT3_18555785_Chip-Seq_ESCs_Mouse0.86804511
167HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.86114878
168PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.84667352
169KLF4_18555785_Chip-Seq_ESCs_Mouse0.84397849
170CSB_26484114_Chip-Seq_FIBROBLAST_Human0.83748907
171EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.82806535
172JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.82381881
173KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.82246556
174HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.81107140
175SOX9_24532713_ChIP-Seq_HFSC_Mouse0.80777015
176ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.80576144

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis6.92130972
2MP0010368_abnormal_lymphatic_system6.32219304
3MP0001879_abnormal_lymphatic_vessel4.93079702
4MP0003045_fibrosis4.83204879
5MP0002653_abnormal_ependyma_morphology4.37396190
6MP0005167_abnormal_blood-brain_barrier4.28940865
7MP0005670_abnormal_white_adipose3.71545781
8MP0003879_abnormal_hair_cell3.63479486
9MP0002138_abnormal_hepatobiliary_system3.43769176
10MP0004272_abnormal_basement_membrane3.31214254
11MP0009780_abnormal_chondrocyte_physiolo3.05047176
12MP0003646_muscle_fatigue2.95435134
13MP0004782_abnormal_surfactant_physiolog2.94449939
14MP0010352_gastrointestinal_tract_polyps2.94139025
15MP0003705_abnormal_hypodermis_morpholog2.78511598
16MP0003724_increased_susceptibility_to2.61535531
17MP0004381_abnormal_hair_follicle2.58909443
18MP0005367_renal/urinary_system_phenotyp2.54734598
19MP0000516_abnormal_urinary_system2.54734598
20MP0002876_abnormal_thyroid_physiology2.51601394
21MP0003828_pulmonary_edema2.45001397
22MP0000569_abnormal_digit_pigmentation2.32555767
23MP0005464_abnormal_platelet_physiology2.21798968
24MP0008995_early_reproductive_senescence2.11004528
25MP0003941_abnormal_skin_development2.06135153
26MP0004084_abnormal_cardiac_muscle2.03661066
27MP0002168_other_aberrant_phenotype2.03024293
28MP0002132_abnormal_respiratory_system1.97148094
29MP0009697_abnormal_copulation1.84154564
30MP0003191_abnormal_cellular_cholesterol1.78357641
31MP0004019_abnormal_vitamin_homeostasis1.68342976
32MP0010386_abnormal_urinary_bladder1.68015101
33MP0008004_abnormal_stomach_pH1.66769444
34MP0004233_abnormal_muscle_weight1.66052056
35MP0000749_muscle_degeneration1.64199581
36MP0004147_increased_porphyrin_level1.60710725
37MP0006054_spinal_hemorrhage1.58585774
38MP0002277_abnormal_respiratory_mucosa1.54636757
39MP0001188_hyperpigmentation1.52477291
40MP0006138_congestive_heart_failure1.52262928
41MP0005595_abnormal_vascular_smooth1.47663615
42MP0000767_abnormal_smooth_muscle1.47605774
43MP0005085_abnormal_gallbladder_physiolo1.47425579
44MP0002127_abnormal_cardiovascular_syste1.44298300
45MP0001958_emphysema1.40323974
46MP0003183_abnormal_peptide_metabolism1.39062594
47MP0002332_abnormal_exercise_endurance1.38449780
48MP0005165_increased_susceptibility_to1.37580240
49MP0003718_maternal_effect1.36533433
50MP0000343_altered_response_to1.35976792
51MP0005360_urolithiasis1.35706339
52MP0005365_abnormal_bile_salt1.34907955
53MP0002796_impaired_skin_barrier1.31074186
54MP0000566_synostosis1.29343290
55MP0003950_abnormal_plasma_membrane1.27988314
56MP0002971_abnormal_brown_adipose1.27556302
57MP0003566_abnormal_cell_adhesion1.25389800
58MP0004484_altered_response_of1.22737979
59MP0006292_abnormal_olfactory_placode1.22688867
60MP0009379_abnormal_foot_pigmentation1.22485710
61MP0001756_abnormal_urination1.21865058
62MP0005501_abnormal_skin_physiology1.19893559
63MP0008875_abnormal_xenobiotic_pharmacok1.18280399
64MP0005666_abnormal_adipose_tissue1.17334832
65MP0003186_abnormal_redox_activity1.13446415
66MP0004036_abnormal_muscle_relaxation1.12108099
67MP0010030_abnormal_orbit_morphology1.11227116
68MP0009764_decreased_sensitivity_to1.10477559
69MP0003786_premature_aging1.10112010
70MP0000249_abnormal_blood_vessel1.09261404
71MP0004130_abnormal_muscle_cell1.07713613
72MP0004215_abnormal_myocardial_fiber1.06797062
73MP0005171_absent_coat_pigmentation1.06413134
74MP0005385_cardiovascular_system_phenoty1.04944939
75MP0001544_abnormal_cardiovascular_syste1.04944939
76MP0003693_abnormal_embryo_hatching1.04438859
77MP0005646_abnormal_pituitary_gland1.03637362
78MP0010234_abnormal_vibrissa_follicle1.03137601
79MP0000015_abnormal_ear_pigmentation1.02970279
80MP0002139_abnormal_hepatobiliary_system1.02482405
81MP0003890_abnormal_embryonic-extraembry1.02157679
82MP0004133_heterotaxia1.00784212
83MP0003959_abnormal_lean_body1.00556887
84MP0010329_abnormal_lipoprotein_level0.99891241
85MP0005330_cardiomyopathy0.99616148
86MP0005076_abnormal_cell_differentiation0.96469794
87MP0008775_abnormal_heart_ventricle0.92621609
88MP0002925_abnormal_cardiovascular_devel0.88941778
89MP0000465_gastrointestinal_hemorrhage0.87522717
90MP0009643_abnormal_urine_homeostasis0.87476477
91MP0001968_abnormal_touch/_nociception0.87455123
92MP0005083_abnormal_biliary_tract0.87424977
93MP0001501_abnormal_sleep_pattern0.86730549
94MP0008058_abnormal_DNA_repair0.85086882
95MP0005075_abnormal_melanosome_morpholog0.84790748
96MP0000678_abnormal_parathyroid_gland0.83526352
97MP0005647_abnormal_sex_gland0.83328201
98MP0003567_abnormal_fetal_cardiomyocyte0.82946741
99MP0000230_abnormal_systemic_arterial0.82800194
100MP0003119_abnormal_digestive_system0.82561441
101MP0001664_abnormal_digestion0.81713203
102MP0008057_abnormal_DNA_replication0.81683210
103MP0002128_abnormal_blood_circulation0.81589850
104MP0005332_abnormal_amino_acid0.81072986
105MP0002295_abnormal_pulmonary_circulatio0.80757477
106MP0002133_abnormal_respiratory_system0.79920360
107MP0005388_respiratory_system_phenotype0.79920360
108MP0001614_abnormal_blood_vessel0.79438912
109MP0003984_embryonic_growth_retardation0.78632310
110MP0004264_abnormal_extraembryonic_tissu0.78537066
111MP0005409_darkened_coat_color0.77560762
112MP0005397_hematopoietic_system_phenotyp0.77201243
113MP0001545_abnormal_hematopoietic_system0.77201243
114MP0003195_calcinosis0.77065960
115MP0002098_abnormal_vibrissa_morphology0.76893883
116MP0002088_abnormal_embryonic_growth/wei0.75884597
117MP0001672_abnormal_embryogenesis/_devel0.75671017
118MP0005380_embryogenesis_phenotype0.75671017
119MP0008874_decreased_physiological_sensi0.75362494
120MP0004883_abnormal_blood_vessel0.74492427
121MP0002086_abnormal_extraembryonic_tissu0.74433018
122MP0010771_integument_phenotype0.74054995
123MP0002075_abnormal_coat/hair_pigmentati0.73599655
124MP0002160_abnormal_reproductive_system0.73149283
125MP0001764_abnormal_homeostasis0.72999389
126MP0005395_other_phenotype0.72127702
127MP0003638_abnormal_response/metabolism_0.70949606
128MP0002095_abnormal_skin_pigmentation0.70255333
129MP0003111_abnormal_nucleus_morphology0.69360034
130MP0000534_abnormal_ureter_morphology0.68712474
131MP0003011_delayed_dark_adaptation0.68468866
132MP0009278_abnormal_bone_marrow0.68420904
133MP0005164_abnormal_response_to0.68095974
134MP0000681_abnormal_thyroid_gland0.68091137
135MP0006035_abnormal_mitochondrial_morpho0.67604636
136MP0010678_abnormal_skin_adnexa0.66470489
137MP0005319_abnormal_enzyme/_coenzyme0.66422604
138MP0000266_abnormal_heart_morphology0.65595149
139MP0002136_abnormal_kidney_physiology0.65406118
140MP0000383_abnormal_hair_follicle0.63879354
141MP0003252_abnormal_bile_duct0.63842491
142MP0003453_abnormal_keratinocyte_physiol0.61787996
143MP0003136_yellow_coat_color0.61719046
144MP0001175_abnormal_lung_morphology0.61214004
145MP0002938_white_spotting0.60781869
146MP0001661_extended_life_span0.60012804
147MP0008872_abnormal_physiological_respon0.59421224
148MP0008877_abnormal_DNA_methylation0.58472483
149MP0003937_abnormal_limbs/digits/tail_de0.58094726
150MP0002254_reproductive_system_inflammat0.57379268
151MP0002733_abnormal_thermal_nociception0.56692829
152MP0009115_abnormal_fat_cell0.56454574
153MP0010630_abnormal_cardiac_muscle0.56183130
154MP0005503_abnormal_tendon_morphology0.56094196
155MP0008770_decreased_survivor_rate0.53556651
156MP0005375_adipose_tissue_phenotype0.46746103
157MP0003300_gastrointestinal_ulcer0.45860460
158MP0003868_abnormal_feces_composition0.44206225
159MP0005174_abnormal_tail_pigmentation0.43411511
160MP0000427_abnormal_hair_cycle0.42564040
161MP0001186_pigmentation_phenotype0.42167497
162MP0000377_abnormal_hair_follicle0.41816542

Predicted human phenotypes

RankGene SetZ-score
1Amelogenesis imperfecta (HP:0000705)8.29908087
2Thyroid-stimulating hormone excess (HP:0002925)7.92763952
3Acanthocytosis (HP:0001927)7.29910807
4Focal motor seizures (HP:0011153)7.03452662
5Congenital ichthyosiform erythroderma (HP:0007431)5.68598232
6Congenital nonbullous ichthyosiform erythroderma (HP:0007479)5.54684045
7Polycythemia (HP:0001901)5.40086300
8Parakeratosis (HP:0001036)4.92099767
9Petechiae (HP:0000967)4.69387418
10Hematochezia (HP:0002573)4.59429841
11Spontaneous hematomas (HP:0007420)4.49866350
12Esophageal varix (HP:0002040)4.38062455
13Aplastic anemia (HP:0001915)4.23549217
14Menorrhagia (HP:0000132)4.09944890
15Purpura (HP:0000979)3.99242561
16Poikilocytosis (HP:0004447)3.92500542
17Pancreatic islet-cell hyperplasia (HP:0004510)3.72499404
18Dialeptic seizures (HP:0011146)3.70683385
19Increased mean platelet volume (HP:0011877)3.57831288
20Abnormality of the hepatic vasculature (HP:0006707)3.49059498
21Prolonged bleeding time (HP:0003010)3.47423029
22Hyperactive renin-angiotensin system (HP:0000841)3.43347724
23Vertebral arch anomaly (HP:0008438)3.43216648
24Portal hypertension (HP:0001409)3.39275677
25Decreased number of large peripheral myelinated nerve fibers (HP:0003387)3.39267826
26Intestinal atresia (HP:0011100)3.35794325
27Hyperglycinuria (HP:0003108)3.28937370
28Difficulty walking (HP:0002355)3.27030549
29Autoimmune hemolytic anemia (HP:0001890)3.22275421
30Abnormal platelet volume (HP:0011876)3.16861764
31Volvulus (HP:0002580)3.13389008
32Abnormality of endocrine pancreas physiology (HP:0012093)3.06978620
33Abnormality of the pancreatic islet cells (HP:0006476)3.06978620
34Conjunctival telangiectasia (HP:0000524)3.05114042
35Aplasia/Hypoplasia of the uvula (HP:0010293)2.98458984
36Abnormality of the nasal mucosa (HP:0000433)2.95820369
37Chromosomal breakage induced by crosslinking agents (HP:0003221)2.93913846
38Epistaxis (HP:0000421)2.91126776
39Abnormality of the vasculature of the conjunctiva (HP:0008054)2.90773634
40Chronic bronchitis (HP:0004469)2.87169369
41Proximal amyotrophy (HP:0007126)2.87028556
42Abnormality of aromatic amino acid family metabolism (HP:0004338)2.86791302
43Absent hand (HP:0004050)2.86219909
44Joint hemorrhage (HP:0005261)2.82338794
45Focal seizures (HP:0007359)2.69662734
46Aortic aneurysm (HP:0004942)2.66789780
47Bilateral sensorineural hearing impairment (HP:0008619)2.62415211
48Chromsome breakage (HP:0040012)2.58187261
49Pulmonary artery stenosis (HP:0004415)2.57035035
50Abnormality of monocarboxylic acid metabolism (HP:0010996)2.54185148
51Poor head control (HP:0002421)2.52119727
52Lack of skin elasticity (HP:0100679)2.49943708
53Abnormality of the pulmonary veins (HP:0011718)2.47497835
54Oligodontia (HP:0000677)2.45902645
55Abnormality of abdominal situs (HP:0011620)2.45363978
56Abdominal situs inversus (HP:0003363)2.45363978
57Pigmentary retinal degeneration (HP:0001146)2.45169006
58Broad alveolar ridges (HP:0000187)2.44652129
59Scapular winging (HP:0003691)2.44219254
60Abnormality of the aortic arch (HP:0012303)2.44177908
61Pulmonary hypertension (HP:0002092)2.41340985
62Overlapping toe (HP:0001845)2.41221868
63Hyperglycinemia (HP:0002154)2.40303303
64Hyperthyroidism (HP:0000836)2.39109284
65Adactyly (HP:0009776)2.35523876
66Duplicated collecting system (HP:0000081)2.33932472
67Hyperkalemia (HP:0002153)2.32251383
68Abnormality of the fetal cardiovascular system (HP:0010948)2.31206307
69Abnormal umbilical cord blood vessels (HP:0011403)2.31206307
70Single umbilical artery (HP:0001195)2.31206307
71Gaze-evoked nystagmus (HP:0000640)2.31036302
72Abnormality of the ileum (HP:0001549)2.30746533
73Right ventricular cardiomyopathy (HP:0011663)2.30696378
74Ileus (HP:0002595)2.30625404
75Synostosis of carpal bones (HP:0005048)2.30467065
76Microcytic anemia (HP:0001935)2.30112715
77Meckel diverticulum (HP:0002245)2.29257555
78Erythroderma (HP:0001019)2.27631083
79Absent radius (HP:0003974)2.26628267
80Aplasia cutis congenita (HP:0001057)2.25932467
81Hyperlipoproteinemia (HP:0010980)2.24771430
82Gangrene (HP:0100758)2.24357619
83Vascular calcification (HP:0004934)2.24056955
84Shawl scrotum (HP:0000049)2.23663977
85Hydroureter (HP:0000072)2.23223399
86Nephroblastoma (Wilms tumor) (HP:0002667)2.23113414
87Ventricular tachycardia (HP:0004756)2.21900605
88Aortic dissection (HP:0002647)2.21639139
89Thickened helices (HP:0000391)2.20823809
90Abnormal hemoglobin (HP:0011902)2.19381983
91Abnormality of glycine metabolism (HP:0010895)2.19129342
92Abnormality of serine family amino acid metabolism (HP:0010894)2.19129342
93Growth hormone excess (HP:0000845)2.17053980
94Congenital, generalized hypertrichosis (HP:0004540)2.15338514
95Ulnar bowing (HP:0003031)2.14961625
96Rectal prolapse (HP:0002035)2.13618385
97Thickened calvaria (HP:0002684)2.12894126
98Breast hypoplasia (HP:0003187)2.09654416
99Dehydration (HP:0001944)2.08259647
100Capillary hemangiomas (HP:0005306)2.06992098
101Embryonal renal neoplasm (HP:0011794)2.06652564
102Testicular atrophy (HP:0000029)2.06460658
103Aplasia involving forearm bones (HP:0009822)2.06112046
104Absent forearm bone (HP:0003953)2.06112046
105Tubular atrophy (HP:0000092)2.05934974
106Cerebellar dysplasia (HP:0007033)2.05227977
107Ectropion (HP:0000656)2.04676132
108Long foot (HP:0001833)2.04247672
109Abnormality of the renal collecting system (HP:0004742)2.03797017
110Broad ribs (HP:0000885)2.03523614
111Central scotoma (HP:0000603)2.02906856
112Colon cancer (HP:0003003)2.01650788
113Cardiovascular calcification (HP:0011915)2.01039380
114Renal cortical cysts (HP:0000803)2.01004571
115Gingival bleeding (HP:0000225)2.00929633
116Enlarged kidneys (HP:0000105)1.99274827
117Cerebral aneurysm (HP:0004944)1.98083626
118Anal stenosis (HP:0002025)1.97481188
119Malignant gastrointestinal tract tumors (HP:0006749)1.97258127
120Gastrointestinal carcinoma (HP:0002672)1.97258127
121Hypoglycemic coma (HP:0001325)1.97127922
122Abnormal pupillary function (HP:0007686)1.96653060
123Septo-optic dysplasia (HP:0100842)1.95721329
124Testicular neoplasm (HP:0010788)1.95689187
125Azoospermia (HP:0000027)1.95235441
126Hypoplastic iliac wings (HP:0002866)1.95182019
127Tachypnea (HP:0002789)1.95157392
128Progressive inability to walk (HP:0002505)1.95070766
129Abnormality of the intrinsic pathway (HP:0010989)1.94823188
130Distal lower limb muscle weakness (HP:0009053)1.94262593
131Porencephaly (HP:0002132)1.94206075
132Stroke (HP:0001297)1.94175208
133Nonprogressive disorder (HP:0003680)1.93672234
134Large for gestational age (HP:0001520)1.92372647
135Tarsal synostosis (HP:0008368)1.92165389
136Interstitial pulmonary disease (HP:0006530)1.92073046
137Deep venous thrombosis (HP:0002625)1.91640624
138Facial cleft (HP:0002006)1.90770017
139Mesomelia (HP:0003027)1.89071670
140Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.88436769
141Abnormality of the common coagulation pathway (HP:0010990)1.88301495
142Onycholysis (HP:0001806)1.87472608
143Hyperpituitarism (HP:0010514)1.87254690
144Visceral angiomatosis (HP:0100761)1.87016893
145Nausea (HP:0002018)1.86601819
146Abnormality of the vocal cords (HP:0008777)1.85871627
147Non-midline cleft lip (HP:0100335)1.85134661
148Hyperammonemia (HP:0001987)1.85009568
149Absent eyebrow (HP:0002223)1.82847914
150Abnormal spermatogenesis (HP:0008669)1.82650414
151Skull defect (HP:0001362)1.82554903
152Pendular nystagmus (HP:0012043)1.81517349
153Abnormality of macular pigmentation (HP:0008002)1.81515290
154Renal salt wasting (HP:0000127)1.81387008
155Severe visual impairment (HP:0001141)1.80889661
156Decreased circulating renin level (HP:0003351)1.80434315
157Agitation (HP:0000713)1.78193795
158Atrioventricular block (HP:0001678)1.77683956
159Redundant skin (HP:0001582)1.77320541
160Dysmetric saccades (HP:0000641)1.76218800
161Scotoma (HP:0000575)1.75977990
162Supernumerary spleens (HP:0009799)1.75509602
163Abnormality of pyrimidine metabolism (HP:0004353)1.75122857
164Subcapsular cataract (HP:0000523)1.74810192
165Hemangiomatosis (HP:0007461)1.74204820
166Muscle fibrillation (HP:0010546)1.73798814
167Increased neuronal autofluorescent lipopigment (HP:0002074)1.73037561
168Facial shape deformation (HP:0011334)1.72788931
169Potter facies (HP:0002009)1.72788931
170Osteomalacia (HP:0002749)1.72753656
171Ureteral duplication (HP:0000073)1.71954240
172Neonatal death (HP:0003811)1.71869180
173Absent toe (HP:0010760)1.71676799
174Mesangial abnormality (HP:0001966)1.71473620
175Dicarboxylic aciduria (HP:0003215)1.70502288
176Abnormality of dicarboxylic acid metabolism (HP:0010995)1.70502288
177Bruising susceptibility (HP:0000978)1.69602147
178Aplasia/hypoplasia of the humerus (HP:0006507)1.69464686
179Abnormality of serum amino acid levels (HP:0003112)1.69098003
180Hyperaldosteronism (HP:0000859)1.68424162
181Radial bowing (HP:0002986)1.66699680
182Horizontal nystagmus (HP:0000666)1.66271927
183Median cleft lip (HP:0000161)1.65898541
184Reduced subcutaneous adipose tissue (HP:0003758)1.65785145
185Congenital hepatic fibrosis (HP:0002612)1.65346611
186Congenital stationary night blindness (HP:0007642)1.64047136

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE19.42121528
2KDR4.73799818
3TGFBR23.85936977
4GRK13.00744754
5EPHA22.91306319
6AKT32.80640139
7STK38L2.64392377
8MYLK2.48002996
9PRKD32.30865421
10MELK2.15125111
11ZAK1.97355796
12MAP2K21.87739456
13IRAK31.87341398
14PDK21.82390371
15EIF2AK21.57148069
16EPHB21.53462037
17BMPR1B1.48339581
18INSRR1.45546024
19TGFBR11.45050808
20MAP3K31.40785073
21RIPK11.37492324
22PINK11.36135303
23TTN1.23734800
24TAOK21.23267934
25LATS11.20946575
26MAP3K21.18064865
27BUB11.15189484
28PDPK11.15033610
29ERN11.14581033
30ADRBK11.14314567
31BCKDK1.04647360
32PDK41.03936673
33PDK31.03936673
34FER1.03741916
35MAP2K30.99709770
36NLK0.99402692
37LMTK20.99074020
38PBK0.96892958
39TTK0.95818474
40WEE10.95209620
41PLK40.93296437
42GRK50.91783520
43NME10.90149404
44KSR20.89237058
45SRPK10.87297436
46MAP3K110.87156549
47BMX0.85784301
48TEC0.83753664
49PRKG20.82677179
50MST40.82139296
51MAPK70.81776848
52FGFR40.79590757
53PAK40.74795095
54TAF10.73664881
55MAPK150.69857013
56MST1R0.68786902
57MAP2K10.68426854
58PIK3CG0.67307736
59CSK0.65697455
60PLK10.63345127
61PRKAA20.60198093
62EIF2AK10.59734022
63PRKD10.59497371
64STK160.59172112
65CSNK1A1L0.57183907
66MKNK20.54852018
67CDK30.54153025
68MAP3K60.52126177
69NUAK10.51477737
70PNCK0.51364055
71IRAK10.50435729
72STK30.49637647
73MET0.49239231
74CAMK1G0.48933793
75TYRO30.48593111
76CDK120.48463025
77AURKB0.46693299
78GRK70.46230977
79YES10.45944345
80AKT20.45158640
81CASK0.44325337
82STK100.43891825
83ERBB40.43530692
84CAMK1D0.43280070
85CDK70.42173349
86BRSK20.40903335
87STK390.40378362
88GSK3A0.39721215
89PTK2B0.39357024
90RPS6KA40.38540162
91EIF2AK30.37558375
92EEF2K0.36347065
93DYRK30.35867672
94ACVR1B0.35597227
95DDR20.35310090
96TSSK60.34511214
97STK240.33641207
98PIM10.32714439
99CDK60.31289488
100CHEK20.30082089
101LATS20.29296661
102PRKCI0.28369630
103CSNK2A10.28074708
104STK380.27968281
105OBSCN0.27219442
106PTK20.27196419
107BRD40.26995501
108PRKAA10.26770622
109MAP3K140.25546336
110PDGFRA0.24786032
111MAP2K60.24575500
112OXSR10.24489862
113IGF1R0.23649951
114PRKCG0.23586835
115PIM20.23571277
116BCR0.23198733
117MAPK120.22848597
118MAPK110.22767925
119CSF1R0.22558357
120PHKG10.22291503
121PHKG20.22291503
122NEK20.21961613
123MAPKAPK30.21486165
124PDK10.20524952
125NEK90.20414801
126STK40.20139339
127TXK0.19897725
128MARK30.19224273
129PRKCE0.19221379
130ADRBK20.19217948
131CAMK2G0.18926983
132BTK0.18649494
133MAPK30.18172872
134FRK0.18044804
135RET0.17446946
136RIPK40.17304024
137TNK20.15889533
138MOS0.15226278
139MAPK10.12780813
140PDGFRB0.12447805
141CSNK1D0.12053055
142ABL10.10105159
143ERBB20.09902590
144PKN20.09007023
145CDK90.07624348
146AKT10.07256804
147NEK60.06508556
148CAMK2A0.06129297
149MAP3K80.05819949
150TAOK30.05249484
151DAPK30.04978066
152WNK40.04924007
153SMG10.04199641
154DAPK20.02685973
155PLK20.02208906
156MAPKAPK50.01077483

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004005.70600824
2Dorso-ventral axis formation_Homo sapiens_hsa043203.59002809
3Phototransduction_Homo sapiens_hsa047443.17744656
4Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001303.10030951
5Propanoate metabolism_Homo sapiens_hsa006402.88351204
6Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.73827566
7Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.43586913
8Fatty acid degradation_Homo sapiens_hsa000712.40322771
9RNA polymerase_Homo sapiens_hsa030202.07927123
10Complement and coagulation cascades_Homo sapiens_hsa046102.07825069
11Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.07728909
12Tryptophan metabolism_Homo sapiens_hsa003802.05346302
13beta-Alanine metabolism_Homo sapiens_hsa004102.03639628
14Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.03314307
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.02526544
16Vitamin digestion and absorption_Homo sapiens_hsa049772.01840324
17Retinol metabolism_Homo sapiens_hsa008302.00715652
18Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.00534761
19PPAR signaling pathway_Homo sapiens_hsa033201.97581137
20* Sphingolipid metabolism_Homo sapiens_hsa006001.95604764
21Fanconi anemia pathway_Homo sapiens_hsa034601.85762612
22Ovarian steroidogenesis_Homo sapiens_hsa049131.84810734
23Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.82491742
24Vitamin B6 metabolism_Homo sapiens_hsa007501.78020352
25ECM-receptor interaction_Homo sapiens_hsa045121.74300448
26Fatty acid metabolism_Homo sapiens_hsa012121.73804956
27Platelet activation_Homo sapiens_hsa046111.71263238
28Folate biosynthesis_Homo sapiens_hsa007901.66494555
29Adherens junction_Homo sapiens_hsa045201.66434401
30Homologous recombination_Homo sapiens_hsa034401.64336609
31Taste transduction_Homo sapiens_hsa047421.62756423
32Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.61158112
33Fatty acid biosynthesis_Homo sapiens_hsa000611.59149959
34Morphine addiction_Homo sapiens_hsa050321.58236999
35Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.57418475
36Selenocompound metabolism_Homo sapiens_hsa004501.51235923
37N-Glycan biosynthesis_Homo sapiens_hsa005101.50843720
38Thyroid cancer_Homo sapiens_hsa052161.50323806
39Pentose and glucuronate interconversions_Homo sapiens_hsa000401.38849879
40Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.37480114
41Caffeine metabolism_Homo sapiens_hsa002321.34896368
42Pyrimidine metabolism_Homo sapiens_hsa002401.33354776
43Purine metabolism_Homo sapiens_hsa002301.31882977
44Proteasome_Homo sapiens_hsa030501.31627120
45Base excision repair_Homo sapiens_hsa034101.26208910
46Mismatch repair_Homo sapiens_hsa034301.23675962
47Cyanoamino acid metabolism_Homo sapiens_hsa004601.21692609
48Phenylalanine metabolism_Homo sapiens_hsa003601.20703439
49Arginine biosynthesis_Homo sapiens_hsa002201.20081188
50Peroxisome_Homo sapiens_hsa041461.19852280
51Primary bile acid biosynthesis_Homo sapiens_hsa001201.19359342
52One carbon pool by folate_Homo sapiens_hsa006701.19188133
53Steroid hormone biosynthesis_Homo sapiens_hsa001401.18009725
54Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.17667691
55Drug metabolism - other enzymes_Homo sapiens_hsa009831.16505093
56Chemical carcinogenesis_Homo sapiens_hsa052041.10417131
57Histidine metabolism_Homo sapiens_hsa003401.10152683
58VEGF signaling pathway_Homo sapiens_hsa043701.10072522
59Arginine and proline metabolism_Homo sapiens_hsa003301.09842841
602-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.05675197
61Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.05429522
62Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.04107658
63Tight junction_Homo sapiens_hsa045301.02297522
64Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.01342869
65Staphylococcus aureus infection_Homo sapiens_hsa051501.00172679
66ABC transporters_Homo sapiens_hsa020100.99089260
67Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.97065062
68Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.96806200
69Glycerolipid metabolism_Homo sapiens_hsa005610.96511616
70Dilated cardiomyopathy_Homo sapiens_hsa054140.96453823
71Small cell lung cancer_Homo sapiens_hsa052220.94571194
72Notch signaling pathway_Homo sapiens_hsa043300.93558842
73Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.93543526
74Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.92970080
75Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.91950358
76Arachidonic acid metabolism_Homo sapiens_hsa005900.90573143
77DNA replication_Homo sapiens_hsa030300.90434379
78Olfactory transduction_Homo sapiens_hsa047400.89960320
79Nitrogen metabolism_Homo sapiens_hsa009100.88076502
80Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.87890053
81Calcium signaling pathway_Homo sapiens_hsa040200.85584139
82Fructose and mannose metabolism_Homo sapiens_hsa000510.85255957
83Lysine degradation_Homo sapiens_hsa003100.84814075
84Phosphatidylinositol signaling system_Homo sapiens_hsa040700.84744873
85Tyrosine metabolism_Homo sapiens_hsa003500.82304465
86Nicotine addiction_Homo sapiens_hsa050330.79892317
87Protein digestion and absorption_Homo sapiens_hsa049740.79342145
88Carbon metabolism_Homo sapiens_hsa012000.78543210
89Leukocyte transendothelial migration_Homo sapiens_hsa046700.77483410
90Serotonergic synapse_Homo sapiens_hsa047260.76166090
91Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.76139361
92Focal adhesion_Homo sapiens_hsa045100.76094152
93Pyruvate metabolism_Homo sapiens_hsa006200.75160221
94Glycosaminoglycan degradation_Homo sapiens_hsa005310.72234976
95Spliceosome_Homo sapiens_hsa030400.71296098
96Endometrial cancer_Homo sapiens_hsa052130.71091640
97Renin-angiotensin system_Homo sapiens_hsa046140.70582244
98Hippo signaling pathway_Homo sapiens_hsa043900.70320882
99Estrogen signaling pathway_Homo sapiens_hsa049150.70093864
100RNA transport_Homo sapiens_hsa030130.69582178
101Pancreatic cancer_Homo sapiens_hsa052120.69499671
102Pentose phosphate pathway_Homo sapiens_hsa000300.69249941
103MicroRNAs in cancer_Homo sapiens_hsa052060.68606552
104Fat digestion and absorption_Homo sapiens_hsa049750.68064266
105AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.67831810
106Basal cell carcinoma_Homo sapiens_hsa052170.67685185
107TGF-beta signaling pathway_Homo sapiens_hsa043500.67497771
108Glutathione metabolism_Homo sapiens_hsa004800.66530158
109Ribosome_Homo sapiens_hsa030100.65933845
110Circadian rhythm_Homo sapiens_hsa047100.64708396
111PI3K-Akt signaling pathway_Homo sapiens_hsa041510.64379000
112Phospholipase D signaling pathway_Homo sapiens_hsa040720.62968273
113Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.62301927
114Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.62088992
115Pancreatic secretion_Homo sapiens_hsa049720.60441206
116Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.58699487
117Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.58290870
118Colorectal cancer_Homo sapiens_hsa052100.58241393
119Basal transcription factors_Homo sapiens_hsa030220.58131051
120Gap junction_Homo sapiens_hsa045400.57937417
121Cysteine and methionine metabolism_Homo sapiens_hsa002700.57316083
122* Metabolic pathways_Homo sapiens_hsa011000.57180996
123Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.56688471
124Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.56375226
125Bile secretion_Homo sapiens_hsa049760.55229711
126Thyroid hormone signaling pathway_Homo sapiens_hsa049190.54776521
127Fatty acid elongation_Homo sapiens_hsa000620.54645931
128GABAergic synapse_Homo sapiens_hsa047270.53450899
129Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.51915187
130Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.51398578
131Bladder cancer_Homo sapiens_hsa052190.51093963
132p53 signaling pathway_Homo sapiens_hsa041150.50223662
133Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.50166537
134Malaria_Homo sapiens_hsa051440.49257443
135Rap1 signaling pathway_Homo sapiens_hsa040150.48108786
136Intestinal immune network for IgA production_Homo sapiens_hsa046720.48035317
137alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.47901431
138Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.46901351
139Maturity onset diabetes of the young_Homo sapiens_hsa049500.46613537
140Starch and sucrose metabolism_Homo sapiens_hsa005000.45582484
141Glycerophospholipid metabolism_Homo sapiens_hsa005640.45518838
142* Sphingolipid signaling pathway_Homo sapiens_hsa040710.45313265
143Vascular smooth muscle contraction_Homo sapiens_hsa042700.43919876
144Linoleic acid metabolism_Homo sapiens_hsa005910.43786740
145Pathways in cancer_Homo sapiens_hsa052000.42575273
146Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.42233743
147Longevity regulating pathway - mammal_Homo sapiens_hsa042110.41973196
148Choline metabolism in cancer_Homo sapiens_hsa052310.40776792
149Chronic myeloid leukemia_Homo sapiens_hsa052200.39219409
150Adipocytokine signaling pathway_Homo sapiens_hsa049200.39154459
151Butanoate metabolism_Homo sapiens_hsa006500.37567659
152cGMP-PKG signaling pathway_Homo sapiens_hsa040220.36465119
153ErbB signaling pathway_Homo sapiens_hsa040120.34373294
154Glutamatergic synapse_Homo sapiens_hsa047240.33512818
155Regulation of actin cytoskeleton_Homo sapiens_hsa048100.33424007
156Inositol phosphate metabolism_Homo sapiens_hsa005620.32352264
157Hematopoietic cell lineage_Homo sapiens_hsa046400.32210230
158Cell cycle_Homo sapiens_hsa041100.28802924
159Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.28405102

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