ACER3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1piRNA metabolic process (GO:0034587)6.87327730
2mitotic metaphase plate congression (GO:0007080)6.08952201
3negative regulation of retinoic acid receptor signaling pathway (GO:0048387)5.92060607
4meiotic chromosome segregation (GO:0045132)5.79660842
5female gamete generation (GO:0007292)5.57076857
6regulation of meiosis (GO:0040020)5.23816950
7monoubiquitinated protein deubiquitination (GO:0035520)5.23481178
8negative regulation of keratinocyte proliferation (GO:0010839)5.21629795
9oocyte maturation (GO:0001556)5.21414315
10mitotic chromosome condensation (GO:0007076)5.20223055
11regulation of exit from mitosis (GO:0007096)5.11480079
12regulation of female gonad development (GO:2000194)5.05042326
13histone H2A monoubiquitination (GO:0035518)4.90638966
14protein K6-linked ubiquitination (GO:0085020)4.88254047
15metaphase plate congression (GO:0051310)4.83886148
16regulation of meiosis I (GO:0060631)4.77281593
17regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.73684073
18DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla4.71239316
19female gonad development (GO:0008585)4.68918623
20regulation of retinoic acid receptor signaling pathway (GO:0048385)4.63185861
21negative regulation of meiosis (GO:0045835)4.58792627
22DNA damage response, signal transduction resulting in transcription (GO:0042772)4.55192266
23male meiosis (GO:0007140)4.43228963
24DNA damage induced protein phosphorylation (GO:0006975)4.36603441
25establishment of chromosome localization (GO:0051303)4.34541917
26regulation of establishment of cell polarity (GO:2000114)4.29901802
27DNA methylation involved in gamete generation (GO:0043046)4.17665313
28notochord development (GO:0030903)4.17390622
29histone lysine demethylation (GO:0070076)4.17221649
30regulation of meiotic cell cycle (GO:0051445)4.16293589
31regulation of keratinocyte proliferation (GO:0010837)4.15898792
32histone H2A ubiquitination (GO:0033522)4.15220316
33positive regulation of mast cell activation (GO:0033005)4.14844151
34regulation of sister chromatid cohesion (GO:0007063)4.14707656
35attachment of spindle microtubules to kinetochore (GO:0008608)4.14321018
36negative regulation of hormone biosynthetic process (GO:0032353)4.12366979
37negative regulation of hormone metabolic process (GO:0032351)4.12366979
38neutrophil activation involved in immune response (GO:0002283)4.11944361
39meiotic cell cycle (GO:0051321)4.10573601
40histone demethylation (GO:0016577)4.08163028
41sister chromatid cohesion (GO:0007062)3.99243229
42regulation of spindle organization (GO:0090224)3.98442256
43mitotic sister chromatid cohesion (GO:0007064)3.98423516
44snRNA transcription (GO:0009301)3.88789660
45negative regulation of smooth muscle cell differentiation (GO:0051151)3.85319108
46positive regulation of mast cell degranulation (GO:0043306)3.84893953
47positive regulation of mast cell activation involved in immune response (GO:0033008)3.84893953
48maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.70905779
49protein dealkylation (GO:0008214)3.70271921
50protein demethylation (GO:0006482)3.70271921
51inner cell mass cell proliferation (GO:0001833)3.69974507
52regulation of histone H3-K27 methylation (GO:0061085)3.61168643
53regulation of mitotic spindle organization (GO:0060236)3.59206726
54negative regulation of cell aging (GO:0090344)3.57067815
55maturation of 5.8S rRNA (GO:0000460)3.55534738
56serotonin metabolic process (GO:0042428)3.54918438
57regulation of transcription from RNA polymerase I promoter (GO:0006356)3.52787803
58chromosome segregation (GO:0007059)3.51811831
59myoblast migration (GO:0051451)3.49843688
60regulation of establishment or maintenance of cell polarity (GO:0032878)3.49656914
61glycerophospholipid catabolic process (GO:0046475)3.49290130
62N-terminal protein amino acid acetylation (GO:0006474)3.45509852
63negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.44309797
64mitotic sister chromatid segregation (GO:0000070)3.42984728
65negative regulation of response to food (GO:0032096)3.41492393
66negative regulation of appetite (GO:0032099)3.41492393
67cell morphogenesis involved in neuron differentiation (GO:0048667)3.39796802
68cellular response to gamma radiation (GO:0071480)3.31326375
69neurotransmitter uptake (GO:0001504)3.28716374
70regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.27281156
71negative regulation of mast cell activation (GO:0033004)3.24622626
72negative regulation of DNA-templated transcription, elongation (GO:0032785)3.24233341
73negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.24233341
74microtubule nucleation (GO:0007020)3.21690897
75regulation of integrin-mediated signaling pathway (GO:2001044)3.20091957
76male meiosis I (GO:0007141)3.18686816
77kinetochore assembly (GO:0051382)3.17512437
78microtubule depolymerization (GO:0007019)3.16879077
79resolution of meiotic recombination intermediates (GO:0000712)3.16659968
80reciprocal DNA recombination (GO:0035825)3.15542737
81reciprocal meiotic recombination (GO:0007131)3.15542737
82CENP-A containing nucleosome assembly (GO:0034080)3.12120048
83platelet dense granule organization (GO:0060155)3.11040039
84oogenesis (GO:0048477)3.10503502
85histone exchange (GO:0043486)3.07915463
86regulation of RIG-I signaling pathway (GO:0039535)3.07200852
87mismatch repair (GO:0006298)3.06596311
88regulation of mast cell activation (GO:0033003)3.06509931
89positive regulation of inositol phosphate biosynthetic process (GO:0060732)3.06038244
90positive regulation of megakaryocyte differentiation (GO:0045654)3.05278230
91meiosis I (GO:0007127)3.02546358
92positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.01349953
93positive regulation of chromosome segregation (GO:0051984)3.01054319
94negative regulation of neurotransmitter transport (GO:0051589)3.00891655
95negative regulation of alcohol biosynthetic process (GO:1902931)3.00843373
96positive regulation of meiosis (GO:0045836)3.00093150
97protein localization to chromosome, centromeric region (GO:0071459)3.00055085
98DNA alkylation (GO:0006305)2.98377174
99DNA methylation (GO:0006306)2.98377174
100replication fork processing (GO:0031297)2.97302626
101DNA replication-independent nucleosome assembly (GO:0006336)2.97062822
102DNA replication-independent nucleosome organization (GO:0034724)2.97062822
103adaptation of signaling pathway (GO:0023058)2.96930651
104meiotic cell cycle process (GO:1903046)2.96697284
105protein localization to chromosome (GO:0034502)2.96616268
106negative regulation of systemic arterial blood pressure (GO:0003085)2.95829783
107nuclear pore complex assembly (GO:0051292)2.95667777
108regulation of double-strand break repair via homologous recombination (GO:0010569)2.94650504
109chromatin remodeling at centromere (GO:0031055)2.93055031
110positive regulation of meiotic cell cycle (GO:0051446)2.93040948
111negative regulation of heart rate (GO:0010459)2.93005129
112regulation of sequestering of triglyceride (GO:0010889)2.92553110
113protein neddylation (GO:0045116)2.92541900
114regulation of glucocorticoid metabolic process (GO:0031943)2.92447915
115negative regulation of meiotic cell cycle (GO:0051447)2.91159815
116histone monoubiquitination (GO:0010390)2.90554249
117ovulation cycle (GO:0042698)2.90472623
118regulation of transforming growth factor beta2 production (GO:0032909)2.88865491
119gene silencing by RNA (GO:0031047)2.88851643
120regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)2.87981031
121meiotic nuclear division (GO:0007126)2.87160662
122base-excision repair, AP site formation (GO:0006285)2.86186232
123negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.86064906
124primary amino compound metabolic process (GO:1901160)2.85832527
125cartilage morphogenesis (GO:0060536)2.85829103
126iron ion import (GO:0097286)2.85671141
127regulation of keratinocyte differentiation (GO:0045616)2.84362573
128signal peptide processing (GO:0006465)2.83503613
129hemidesmosome assembly (GO:0031581)2.76415823
130positive regulation of toll-like receptor signaling pathway (GO:0034123)2.74752691
131membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.72612586
132positive regulation of oligodendrocyte differentiation (GO:0048714)2.72330998
133negative regulation of protein localization to cell surface (GO:2000009)2.72114136
134myelin assembly (GO:0032288)2.70227891
135cellular biogenic amine catabolic process (GO:0042402)2.70185478
136amine catabolic process (GO:0009310)2.70185478
137phosphatidylinositol acyl-chain remodeling (GO:0036149)2.67751408
138positive regulation of leukocyte degranulation (GO:0043302)2.63397320
139phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.62067980
140fatty acid elongation (GO:0030497)2.60174196
141long-chain fatty acid biosynthetic process (GO:0042759)2.59563108
142negative regulation of platelet activation (GO:0010544)2.58168570
143negative regulation of lipid storage (GO:0010888)2.56118395
144sulfation (GO:0051923)2.55496400
145leukocyte migration involved in inflammatory response (GO:0002523)2.54833961
146phospholipid homeostasis (GO:0055091)2.53699801
147Sertoli cell development (GO:0060009)2.50482339
148regulation of platelet activation (GO:0010543)2.48375121
149regulation of neurotransmitter uptake (GO:0051580)2.47985965
150regulation of clathrin-mediated endocytosis (GO:2000369)2.46865836
151prostate gland growth (GO:0060736)2.46422321
152long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.41625546
153positive regulation of cAMP-mediated signaling (GO:0043950)2.41378833
154regulation of inositol phosphate biosynthetic process (GO:0010919)2.41288377
155cellular response to ATP (GO:0071318)2.41244312
156phosphatidylcholine acyl-chain remodeling (GO:0036151)2.40754743
157response to xenobiotic stimulus (GO:0009410)2.39999603
158neutrophil activation (GO:0042119)2.39854827
159indole-containing compound metabolic process (GO:0042430)2.37914415
160phagocytosis, recognition (GO:0006910)2.37820526
161microglial cell activation (GO:0001774)2.36702242
162positive regulation of cellular amide metabolic process (GO:0034250)2.35921042
163phosphatidylserine acyl-chain remodeling (GO:0036150)2.35798942
164water-soluble vitamin biosynthetic process (GO:0042364)2.35503078
165estrogen metabolic process (GO:0008210)2.34708673
166neuronal action potential propagation (GO:0019227)2.34502631
167thrombin receptor signaling pathway (GO:0070493)2.33992192
168import into cell (GO:0098657)2.33657004
169gamma-aminobutyric acid transport (GO:0015812)2.33202951
170regulation of macrophage derived foam cell differentiation (GO:0010743)2.31919799
171phagocytosis, engulfment (GO:0006911)2.31231435
172CDP-diacylglycerol biosynthetic process (GO:0016024)2.30252579
173regulation of neuron projection regeneration (GO:0070570)2.26782142
174regulation of axon regeneration (GO:0048679)2.26782142
175magnesium ion transport (GO:0015693)2.26776708
176regulation of cilium movement (GO:0003352)2.25293568
177fatty-acyl-CoA metabolic process (GO:0035337)2.24814865
178dermatan sulfate biosynthetic process (GO:0030208)2.24798644
179auditory behavior (GO:0031223)2.23161915
180protein prenylation (GO:0018342)2.23018601
181prenylation (GO:0097354)2.23018601
182granulocyte activation (GO:0036230)2.22840051
183ether lipid metabolic process (GO:0046485)2.22358270
184tryptophan catabolic process (GO:0006569)2.22014570
185indole-containing compound catabolic process (GO:0042436)2.22014570
186indolalkylamine catabolic process (GO:0046218)2.22014570
187mechanosensory behavior (GO:0007638)2.21029679
188C4-dicarboxylate transport (GO:0015740)2.20795927
189chondroitin sulfate catabolic process (GO:0030207)2.20159633
190axon ensheathment in central nervous system (GO:0032291)2.19988495
191central nervous system myelination (GO:0022010)2.19988495
192behavioral response to cocaine (GO:0048148)2.19295171
193nonmotile primary cilium assembly (GO:0035058)2.19107161
194L-amino acid import (GO:0043092)2.17656610
195glycerol metabolic process (GO:0006071)2.15577070
196intracellular pH reduction (GO:0051452)2.15575427
197regulation of response to food (GO:0032095)2.14962312

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human4.53254607
2SMAD_19615063_ChIP-ChIP_OVARY_Human3.79908818
3E2F7_22180533_ChIP-Seq_HELA_Human3.67167964
4SALL1_21062744_ChIP-ChIP_HESCs_Human3.46334267
5MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.27839809
6KAP1_22055183_ChIP-Seq_ESCs_Mouse3.25052644
7GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.82339990
8FLI1_27457419_Chip-Seq_LIVER_Mouse2.72497143
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.65280710
10VDR_22108803_ChIP-Seq_LS180_Human2.51038081
11PCGF2_27294783_Chip-Seq_ESCs_Mouse2.42187323
12EZH2_22144423_ChIP-Seq_EOC_Human2.39025783
13BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.29150206
14POU3F2_20337985_ChIP-ChIP_501MEL_Human2.16165035
15SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.12241851
16SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.12126123
17SUZ12_27294783_Chip-Seq_NPCs_Mouse2.03459174
18TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.02627425
19IGF1R_20145208_ChIP-Seq_DFB_Human1.97877712
20NANOG_18555785_Chip-Seq_ESCs_Mouse1.95415265
21CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.91278590
22E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.89720904
23NFE2_27457419_Chip-Seq_LIVER_Mouse1.87615154
24AR_21909140_ChIP-Seq_LNCAP_Human1.86468702
25OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.85859669
26TP63_19390658_ChIP-ChIP_HaCaT_Human1.84590246
27RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.82099482
28ER_23166858_ChIP-Seq_MCF-7_Human1.81201376
29BP1_19119308_ChIP-ChIP_Hs578T_Human1.80819679
30* SMAD4_21799915_ChIP-Seq_A2780_Human1.79834404
31* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.79398441
32CDX2_19796622_ChIP-Seq_MESCs_Mouse1.77899157
33TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.77357455
34NRF2_20460467_ChIP-Seq_MEFs_Mouse1.76995263
35NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.76995263
36FUS_26573619_Chip-Seq_HEK293_Human1.76544198
37EZH2_27294783_Chip-Seq_NPCs_Mouse1.75775343
38LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.75188953
39MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.74797706
40UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.70731160
41AR_25329375_ChIP-Seq_VCAP_Human1.70539950
42ZNF274_21170338_ChIP-Seq_K562_Hela1.61607108
43EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.60032881
44RNF2_27304074_Chip-Seq_NSC_Mouse1.59669625
45GATA1_26923725_Chip-Seq_HPCs_Mouse1.58376423
46SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.54855334
47STAT3_18555785_Chip-Seq_ESCs_Mouse1.53513300
48ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.50903872
49E2F4_17652178_ChIP-ChIP_JURKAT_Human1.49888873
50SOX2_18555785_Chip-Seq_ESCs_Mouse1.47956017
51ZFP57_27257070_Chip-Seq_ESCs_Mouse1.47813646
52TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.47126162
53POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.47126162
54PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.46876212
55CTBP1_25329375_ChIP-Seq_LNCAP_Human1.45283125
56KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.45085275
57BCAT_22108803_ChIP-Seq_LS180_Human1.44848743
58SMAD3_21741376_ChIP-Seq_EPCs_Human1.44543040
59TCF4_23295773_ChIP-Seq_U87_Human1.44542497
60RUNX1_26923725_Chip-Seq_HPCs_Mouse1.44526511
61NMYC_18555785_Chip-Seq_ESCs_Mouse1.44046872
62CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43584092
63SUZ12_18555785_Chip-Seq_ESCs_Mouse1.43495493
64CMYC_18555785_Chip-Seq_ESCs_Mouse1.43188009
65TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.43024546
66E2F1_18555785_Chip-Seq_ESCs_Mouse1.42982122
67NR3C1_21868756_ChIP-Seq_MCF10A_Human1.42586111
68ESR1_20079471_ChIP-ChIP_T-47D_Human1.40964476
69TBL1_22424771_ChIP-Seq_293T_Human1.40923046
70EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.40756946
71P53_22387025_ChIP-Seq_ESCs_Mouse1.40576601
72TCF4_22108803_ChIP-Seq_LS180_Human1.40282520
73TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.39341515
74ARNT_22903824_ChIP-Seq_MCF-7_Human1.39176038
75AHR_22903824_ChIP-Seq_MCF-7_Human1.38171390
76OCT4_18555785_Chip-Seq_ESCs_Mouse1.37915132
77* CJUN_26792858_Chip-Seq_BT549_Human1.37537171
78CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.36560116
79ZFX_18555785_Chip-Seq_ESCs_Mouse1.35717150
80STAT3_23295773_ChIP-Seq_U87_Human1.35518035
81HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.33801593
82EWS_26573619_Chip-Seq_HEK293_Human1.31142891
83MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.30889379
84KLF4_18555785_Chip-Seq_ESCs_Mouse1.30406720
85CTCF_18555785_Chip-Seq_ESCs_Mouse1.29800542
86* NFYA_21822215_ChIP-Seq_K562_Human1.28996037
87KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.28868898
88TOP2B_26459242_ChIP-Seq_MCF-7_Human1.28650276
89ESRRB_18555785_Chip-Seq_ESCs_Mouse1.27139725
90GBX2_23144817_ChIP-Seq_PC3_Human1.26390769
91NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.26065608
92GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.25886534
93FLI1_21867929_ChIP-Seq_TH2_Mouse1.25292559
94P300_18555785_Chip-Seq_ESCs_Mouse1.24944974
95FOXM1_26456572_ChIP-Seq_MCF-7_Human1.24013309
96CDX2_22108803_ChIP-Seq_LS180_Human1.23941414
97* STAT1_17558387_ChIP-Seq_HELA_Human1.23394066
98* CBP_20019798_ChIP-Seq_JUKART_Human1.22269419
99* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.22269419
100NANOG_19829295_ChIP-Seq_ESCs_Human1.22182528
101SOX2_19829295_ChIP-Seq_ESCs_Human1.22182528
102E2F1_21310950_ChIP-Seq_MCF-7_Human1.21172207
103TP53_16413492_ChIP-PET_HCT116_Human1.20566043
104PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.20475453
105HNFA_21074721_ChIP-Seq_CACO-2_Human1.20102005
106ETV1_20927104_ChIP-Seq_GIST48_Human1.18353097
107SMAD4_21741376_ChIP-Seq_EPCs_Human1.18215615
108* TP63_23658742_ChIP-Seq_EP156T_Human1.17944520
109CRX_20693478_ChIP-Seq_RETINA_Mouse1.17591777
110FOXA1_21572438_ChIP-Seq_LNCaP_Human1.17545728
111OCT4_21477851_ChIP-Seq_ESCs_Mouse1.16901543
112RUNX1_27457419_Chip-Seq_LIVER_Mouse1.16785106
113RUNX2_22187159_ChIP-Seq_PCA_Human1.16097829
114* IRF8_27001747_Chip-Seq_BMDM_Mouse1.15568971
115PCGF2_27294783_Chip-Seq_NPCs_Mouse1.15226548
116SOX2_21211035_ChIP-Seq_LN229_Gbm1.14202578
117CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.11561977
118GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.09841590
119JUN_21703547_ChIP-Seq_K562_Human1.08840435
120NFYB_21822215_ChIP-Seq_K562_Human1.08309798
121HTT_18923047_ChIP-ChIP_STHdh_Human1.08111100
122CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.08061835
123PHF8_20622853_ChIP-Seq_HELA_Human1.08021915
124Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.08010150
125FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.07799773
126TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07276849
127SMAD1_18555785_Chip-Seq_ESCs_Mouse1.06319465
128TAF15_26573619_Chip-Seq_HEK293_Human1.05292289
129MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.03383754
130EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.01846100
131SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.01801696
132PIAS1_25552417_ChIP-Seq_VCAP_Human1.01645367
133STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.01507341
134TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.01498880
135GATA6_21074721_ChIP-Seq_CACO-2_Human1.00753986
136CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.00711699
137PRDM14_20953172_ChIP-Seq_ESCs_Human1.00127988
138P300_19829295_ChIP-Seq_ESCs_Human0.99928998
139PU1_27457419_Chip-Seq_LIVER_Mouse0.99521845
140IRF8_21731497_ChIP-ChIP_J774_Mouse0.99320598
141RBPJ_21746931_ChIP-Seq_IB4_Human0.98719997
142KDM2B_26808549_Chip-Seq_REH_Human0.98467829
143* TAL1_26923725_Chip-Seq_HPCs_Mouse0.98385565
144IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.97109817
145ZNF217_24962896_ChIP-Seq_MCF-7_Human0.96486283
146CTBP2_25329375_ChIP-Seq_LNCAP_Human0.96174755

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005451_abnormal_body_composition5.47736917
2MP0003718_maternal_effect4.65139751
3MP0003646_muscle_fatigue3.90979959
4MP0002102_abnormal_ear_morphology3.55846867
5MP0003693_abnormal_embryo_hatching3.55599861
6MP0008877_abnormal_DNA_methylation3.48276893
7MP0006292_abnormal_olfactory_placode3.00523817
8MP0003111_abnormal_nucleus_morphology2.98048285
9MP0003077_abnormal_cell_cycle2.94046691
10MP0003787_abnormal_imprinting2.83025380
11MP0006054_spinal_hemorrhage2.69074736
12MP0010094_abnormal_chromosome_stability2.67232876
13MP0005408_hypopigmentation2.65545928
14MP0008004_abnormal_stomach_pH2.53345768
15MP0000566_synostosis2.52759981
16MP0001119_abnormal_female_reproductive2.51000369
17MP0000579_abnormal_nail_morphology2.46964334
18MP0005174_abnormal_tail_pigmentation2.46339584
19MP0003937_abnormal_limbs/digits/tail_de2.38828433
20MP0003699_abnormal_female_reproductive2.34757698
21MP0002653_abnormal_ependyma_morphology2.29028898
22MP0005395_other_phenotype2.27368378
23MP0002736_abnormal_nociception_after2.26485037
24MP0003195_calcinosis2.25801827
25MP0005464_abnormal_platelet_physiology2.20628456
26MP0005167_abnormal_blood-brain_barrier2.06919502
27MP0008007_abnormal_cellular_replicative2.06059959
28MP0001929_abnormal_gametogenesis2.05357431
29MP0003724_increased_susceptibility_to2.04258618
30MP0001968_abnormal_touch/_nociception2.00737190
31MP0002210_abnormal_sex_determination1.94611175
32MP0008057_abnormal_DNA_replication1.93503473
33MP0003011_delayed_dark_adaptation1.91475704
34MP0000653_abnormal_sex_gland1.87064580
35MP0000015_abnormal_ear_pigmentation1.82211799
36MP0005646_abnormal_pituitary_gland1.75696862
37MP0001486_abnormal_startle_reflex1.74926770
38MP0005171_absent_coat_pigmentation1.74863360
39MP0000569_abnormal_digit_pigmentation1.74816789
40MP0000647_abnormal_sebaceous_gland1.73885264
41MP0003880_abnormal_central_pattern1.73037677
42MP0005551_abnormal_eye_electrophysiolog1.71255930
43MP0005310_abnormal_salivary_gland1.70904188
44MP0008058_abnormal_DNA_repair1.70314005
45MP0002090_abnormal_vision1.70029363
46MP0009046_muscle_twitch1.69507750
47MP0004185_abnormal_adipocyte_glucose1.66362258
48MP0004019_abnormal_vitamin_homeostasis1.65483837
49MP0002095_abnormal_skin_pigmentation1.65353106
50MP0004957_abnormal_blastocyst_morpholog1.61934053
51MP0003315_abnormal_perineum_morphology1.60101061
52MP0002249_abnormal_larynx_morphology1.55636144
53MP0001346_abnormal_lacrimal_gland1.53697944
54MP0002272_abnormal_nervous_system1.53393957
55MP0000920_abnormal_myelination1.53017114
56MP0002876_abnormal_thyroid_physiology1.52938491
57MP0008260_abnormal_autophagy1.51045945
58MP0001970_abnormal_pain_threshold1.50643019
59MP0000343_altered_response_to1.49252096
60MP0004885_abnormal_endolymph1.47227865
61MP0001851_eye_inflammation1.45912564
62MP0004130_abnormal_muscle_cell1.44895321
63MP0002733_abnormal_thermal_nociception1.44806535
64MP0001485_abnormal_pinna_reflex1.43418903
65MP0002064_seizures1.41005546
66MP0010329_abnormal_lipoprotein_level1.40450828
67MP0003633_abnormal_nervous_system1.39727897
68MP0004147_increased_porphyrin_level1.37598203
69MP0001145_abnormal_male_reproductive1.36324348
70MP0010307_abnormal_tumor_latency1.32326792
71MP0002638_abnormal_pupillary_reflex1.31034702
72MP0000350_abnormal_cell_proliferation1.30439549
73MP0009764_decreased_sensitivity_to1.30320861
74MP0005257_abnormal_intraocular_pressure1.30138210
75MP0003638_abnormal_response/metabolism_1.29468932
76MP0008932_abnormal_embryonic_tissue1.29426564
77MP0005409_darkened_coat_color1.28259664
78MP0005253_abnormal_eye_physiology1.28154296
79MP0003950_abnormal_plasma_membrane1.27252318
80MP0009745_abnormal_behavioral_response1.27145117
81MP0000639_abnormal_adrenal_gland1.26904375
82MP0001501_abnormal_sleep_pattern1.26291614
83MP0002148_abnormal_hypersensitivity_rea1.25586053
84MP0006072_abnormal_retinal_apoptosis1.25529286
85MP0001529_abnormal_vocalization1.22963569
86MP0004215_abnormal_myocardial_fiber1.20743110
87MP0000230_abnormal_systemic_arterial1.19834225
88MP0000427_abnormal_hair_cycle1.19331808
89MP0003690_abnormal_glial_cell1.17742980
90MP0003121_genomic_imprinting1.16748883
91MP0003890_abnormal_embryonic-extraembry1.16519760
92MP0001440_abnormal_grooming_behavior1.15836873
93MP0003631_nervous_system_phenotype1.15330736
94MP0002161_abnormal_fertility/fecundity1.14086275
95MP0001915_intracranial_hemorrhage1.14003828
96MP0008872_abnormal_physiological_respon1.13677064
97MP0000604_amyloidosis1.12424659
98MP0000383_abnormal_hair_follicle1.12266630
99MP0002396_abnormal_hematopoietic_system1.12019446
100MP0002572_abnormal_emotion/affect_behav1.11873224
101MP0003186_abnormal_redox_activity1.11241437
102MP0002163_abnormal_gland_morphology1.10788192
103MP0005187_abnormal_penis_morphology1.09893302
104MP0003755_abnormal_palate_morphology1.09471438
105MP0002085_abnormal_embryonic_tissue1.09340199
106MP0000490_abnormal_crypts_of1.08764502
107MP0000371_diluted_coat_color1.08156646
108MP0003806_abnormal_nucleotide_metabolis1.07738688
109MP0000462_abnormal_digestive_system1.06330116
110MP0005647_abnormal_sex_gland1.04357759
111MP0004742_abnormal_vestibular_system1.03202430
112MP0003632_abnormal_nervous_system1.02720383
113MP0000538_abnormal_urinary_bladder1.01986567
114MP0005670_abnormal_white_adipose1.01517520
115MP0002971_abnormal_brown_adipose1.01033167
116MP0004142_abnormal_muscle_tone1.01005466
117MP0004134_abnormal_chest_morphology0.98470146
118MP0005058_abnormal_lysosome_morphology0.95661803
119MP0010386_abnormal_urinary_bladder0.94298968
120MP0003136_yellow_coat_color0.94157403
121MP0005379_endocrine/exocrine_gland_phen0.93396913
122MP0008775_abnormal_heart_ventricle0.93297969
123MP0004043_abnormal_pH_regulation0.92775170
124MP0003329_amyloid_beta_deposits0.92734731
125MP0001545_abnormal_hematopoietic_system0.91987076
126MP0005397_hematopoietic_system_phenotyp0.91987076
127MP0009053_abnormal_anal_canal0.91899815
128MP0003172_abnormal_lysosome_physiology0.90775274
129MP0001730_embryonic_growth_arrest0.90158692
130MP0000613_abnormal_salivary_gland0.89480780
131MP0002067_abnormal_sensory_capabilities0.88974833
132MP0005535_abnormal_body_temperature0.88709192
133MP0005084_abnormal_gallbladder_morpholo0.88244429
134MP0002098_abnormal_vibrissa_morphology0.87291725
135MP0010678_abnormal_skin_adnexa0.87058639
136MP0009250_abnormal_appendicular_skeleto0.86469966
137MP0003075_altered_response_to0.86420152
138MP0000767_abnormal_smooth_muscle0.85940461
139MP0002063_abnormal_learning/memory/cond0.85769775
140MP0003828_pulmonary_edema0.85668393
141MP0005621_abnormal_cell_physiology0.85037505
142MP0003878_abnormal_ear_physiology0.85021359
143MP0005377_hearing/vestibular/ear_phenot0.85021359
144MP0003191_abnormal_cellular_cholesterol0.84624955
145MP0000432_abnormal_head_morphology0.84415747
146MP0005197_abnormal_uvea_morphology0.83868471
147MP0002229_neurodegeneration0.83740757
148MP0005195_abnormal_posterior_eye0.83699057
149MP0002084_abnormal_developmental_patter0.83354155
150MP0002734_abnormal_mechanical_nocicepti0.83259144
151MP0002177_abnormal_outer_ear0.82687877
152MP0008875_abnormal_xenobiotic_pharmacok0.82114011
153MP0002877_abnormal_melanocyte_morpholog0.81293203
154MP0005380_embryogenesis_phenotype0.80491857
155MP0001672_abnormal_embryogenesis/_devel0.80491857
156MP0004264_abnormal_extraembryonic_tissu0.80211743
157MP0008995_early_reproductive_senescence0.79827716
158MP0001177_atelectasis0.79258376
159MP0001905_abnormal_dopamine_level0.79216081
160MP0002019_abnormal_tumor_incidence0.77324074
161MP0002118_abnormal_lipid_homeostasis0.76075479
162MP0005386_behavior/neurological_phenoty0.75663455
163MP0004924_abnormal_behavior0.75663455
164MP0000778_abnormal_nervous_system0.75303229
165MP0003698_abnormal_male_reproductive0.75182737
166MP0005595_abnormal_vascular_smooth0.74997294
167MP0005164_abnormal_response_to0.74341315
168MP0000627_abnormal_mammary_gland0.73808277
169MP0010368_abnormal_lymphatic_system0.73460413
170MP0003123_paternal_imprinting0.72233337
171MP0002109_abnormal_limb_morphology0.71731469
172MP0005248_abnormal_Harderian_gland0.70058708
173MP0009384_cardiac_valve_regurgitation0.69747387
174MP0001697_abnormal_embryo_size0.69555138
175MP0009333_abnormal_splenocyte_physiolog0.67979239
176MP0002168_other_aberrant_phenotype0.67268279
177MP0003453_abnormal_keratinocyte_physiol0.67217794
178MP0003868_abnormal_feces_composition0.66981725
179MP0003763_abnormal_thymus_physiology0.63804236
180MP0003935_abnormal_craniofacial_develop0.63690284
181MP0002233_abnormal_nose_morphology0.62870624
182MP0003938_abnormal_ear_development0.61967712
183MP0003091_abnormal_cell_migration0.59513793
184MP0002277_abnormal_respiratory_mucosa0.54358171
185MP0002116_abnormal_craniofacial_bone0.52155178

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)6.12952529
2Chromsome breakage (HP:0040012)5.99538165
3Male infertility (HP:0003251)5.86066794
4Papillary thyroid carcinoma (HP:0002895)5.70515666
5Prostate neoplasm (HP:0100787)5.20959449
6Birth length less than 3rd percentile (HP:0003561)4.33146928
7Facial hemangioma (HP:0000329)4.07153228
8Flat capital femoral epiphysis (HP:0003370)4.03878454
9Adrenal hypoplasia (HP:0000835)3.74571409
10Abnormality of the fingertips (HP:0001211)3.71671752
11Acute myeloid leukemia (HP:0004808)3.56708426
12Capillary hemangiomas (HP:0005306)3.56073401
13Shawl scrotum (HP:0000049)3.49447129
14Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.48898890
15Abnormality of alanine metabolism (HP:0010916)3.48898890
16Hyperalaninemia (HP:0003348)3.48898890
17Breast hypoplasia (HP:0003187)3.46327882
18Disinhibition (HP:0000734)3.40838721
19Patellar aplasia (HP:0006443)3.36562461
20Abnormality of chromosome stability (HP:0003220)3.34184663
21Hemiparesis (HP:0001269)3.31424555
22Abnormality of binocular vision (HP:0011514)3.30370904
23Diplopia (HP:0000651)3.30370904
24Aplasia/Hypoplasia of the uvula (HP:0010293)3.29818027
25Ectopic kidney (HP:0000086)3.27562893
26Abnormality of the preputium (HP:0100587)3.26598814
27Thyroid carcinoma (HP:0002890)3.19431594
28Breast aplasia (HP:0100783)3.19002612
29Abnormality of the labia minora (HP:0012880)3.15130661
30Lip pit (HP:0100267)3.14882763
31Aplasia/Hypoplasia of the breasts (HP:0010311)3.10900444
32Meckel diverticulum (HP:0002245)3.10744824
33Hemiplegia (HP:0002301)3.10097018
34Hyperventilation (HP:0002883)3.06234751
35Aplasia/Hypoplasia of the patella (HP:0006498)3.04942169
36Abolished electroretinogram (ERG) (HP:0000550)2.99075920
37Inappropriate behavior (HP:0000719)2.93984919
38Petechiae (HP:0000967)2.93979898
39Decreased central vision (HP:0007663)2.90644297
40Clubbing of toes (HP:0100760)2.89981160
41Abnormality of the ileum (HP:0001549)2.87642409
42Abnormality of the prostate (HP:0008775)2.81103914
43Progressive cerebellar ataxia (HP:0002073)2.80208935
44Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.78280130
45Hypoplasia of the fovea (HP:0007750)2.78068848
46Aplasia/Hypoplasia of the fovea (HP:0008060)2.78068848
47Abnormality of glycolipid metabolism (HP:0010969)2.76940376
48Abnormality of liposaccharide metabolism (HP:0010968)2.76940376
49Abnormality of glycosphingolipid metabolism (HP:0004343)2.76940376
50Congenital sensorineural hearing impairment (HP:0008527)2.71032192
51Increased cerebral lipofuscin (HP:0011813)2.69982182
52Pancreatic cysts (HP:0001737)2.69424823
53Genetic anticipation (HP:0003743)2.66544568
54Oligodactyly (hands) (HP:0001180)2.66176110
55Agitation (HP:0000713)2.62241041
56Arterial tortuosity (HP:0005116)2.61128471
57True hermaphroditism (HP:0010459)2.55372821
58Abnormality of lateral ventricle (HP:0030047)2.47844076
59Increased neuronal autofluorescent lipopigment (HP:0002074)2.47543083
60Vacuolated lymphocytes (HP:0001922)2.46675339
61Chorioretinal atrophy (HP:0000533)2.45904925
62Sensorimotor neuropathy (HP:0007141)2.43652274
63Spondylolisthesis (HP:0003302)2.39656037
64Abnormality of the fovea (HP:0000493)2.38987511
65Premature ovarian failure (HP:0008209)2.37677841
66Myelodysplasia (HP:0002863)2.37194221
67Infertility (HP:0000789)2.36542529
68Oligodactyly (HP:0012165)2.33571984
69Polyphagia (HP:0002591)2.29080829
70Abnormality of the carotid arteries (HP:0005344)2.28174090
71Small intestinal stenosis (HP:0012848)2.28121900
72Duodenal stenosis (HP:0100867)2.28121900
73Hypergonadotropic hypogonadism (HP:0000815)2.27031690
74Sparse lateral eyebrow (HP:0005338)2.26099387
75Overlapping toe (HP:0001845)2.24512551
76Mutism (HP:0002300)2.24321589
77Anterior segment dysgenesis (HP:0007700)2.24228891
78Abnormality of midbrain morphology (HP:0002418)2.21662500
79Molar tooth sign on MRI (HP:0002419)2.21662500
80Vascular tortuosity (HP:0004948)2.21383998
81Agnosia (HP:0010524)2.20865790
82Congenital, generalized hypertrichosis (HP:0004540)2.20770116
83Midline defect of the nose (HP:0004122)2.19813341
84Azoospermia (HP:0000027)2.19638097
85Increased mean platelet volume (HP:0011877)2.17780050
86Long nose (HP:0003189)2.16003484
87Insulin-resistant diabetes mellitus (HP:0000831)2.15908573
88Short thumb (HP:0009778)2.14521803
89Action tremor (HP:0002345)2.14122042
90Global brain atrophy (HP:0002283)2.07383981
91Hypoplasia of the uterus (HP:0000013)2.06331508
92Widely spaced teeth (HP:0000687)2.06195279
93Primary amenorrhea (HP:0000786)2.05391432
94Secondary amenorrhea (HP:0000869)2.05312952
95Medial flaring of the eyebrow (HP:0010747)2.05231283
96Microglossia (HP:0000171)2.05191717
97Fragile nails (HP:0001808)2.04827664
98Neurofibrillary tangles (HP:0002185)2.04601221
99Abnormality of chromosome segregation (HP:0002916)2.04314781
100Short hallux (HP:0010109)2.03354724
101Adactyly (HP:0009776)2.03127118
102Hypoplastic iliac wings (HP:0002866)2.03069392
103Recurrent bacterial skin infections (HP:0005406)2.02506137
104Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.01961766
105Fair hair (HP:0002286)2.00413721
106Myocardial infarction (HP:0001658)1.99473425
107Abnormal spermatogenesis (HP:0008669)1.98817407
108Prolonged bleeding time (HP:0003010)1.97738824
109Abnormality of the phalanges of the hallux (HP:0010057)1.97421363
110Gaze-evoked nystagmus (HP:0000640)1.96649911
111Cortical dysplasia (HP:0002539)1.96023859
112Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.95998662
113Degeneration of the lateral corticospinal tracts (HP:0002314)1.95998662
114Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.95405457
115Abnormality of the epiphysis of the femoral head (HP:0010574)1.95298123
116Abnormality of the proximal phalanges of the hand (HP:0009834)1.95115225
117Pulmonary fibrosis (HP:0002206)1.94945966
118Spontaneous abortion (HP:0005268)1.94790260
119Milia (HP:0001056)1.93937132
120Aplasia/Hypoplasia of the macula (HP:0008059)1.93670084
121Aplasia/Hypoplasia of the hallux (HP:0008362)1.93056308
122Bone cyst (HP:0012062)1.92765193
123Sandal gap (HP:0001852)1.92577414
124Epidermoid cyst (HP:0200040)1.92347134
125Abnormality of the femoral head (HP:0003368)1.91967951
126Confusion (HP:0001289)1.90959347
127Abnormality of male internal genitalia (HP:0000022)1.90703203
128Cystic hygroma (HP:0000476)1.90281098
129Albinism (HP:0001022)1.89864529
130Gait imbalance (HP:0002141)1.89663912
131Choroideremia (HP:0001139)1.87749807
132Furrowed tongue (HP:0000221)1.87599566
133Pancreatic fibrosis (HP:0100732)1.87052483
134Tubular atrophy (HP:0000092)1.86348208
135Generalized hypopigmentation of hair (HP:0011358)1.86201277
136Clumsiness (HP:0002312)1.85343424
137Abnormality of the phalanges of the 2nd finger (HP:0009541)1.85085274
138Congenital stationary night blindness (HP:0007642)1.84918744
139Sloping forehead (HP:0000340)1.84682529
140Dyskinesia (HP:0100660)1.82559462
141Vascular calcification (HP:0004934)1.82433862
142Absent speech (HP:0001344)1.82360459
143Abnormality of incisor morphology (HP:0011063)1.82050699
144Inability to walk (HP:0002540)1.81518166
145Methylmalonic acidemia (HP:0002912)1.79975109
146Erectile abnormalities (HP:0100639)1.79831309
147Drooling (HP:0002307)1.79049315
148Progressive inability to walk (HP:0002505)1.78180965
149Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.77676233
150Abnormality of femoral epiphyses (HP:0006499)1.77676233
151Congenital primary aphakia (HP:0007707)1.77150366
152Metabolic alkalosis (HP:0200114)1.76803809
153Abnormal platelet volume (HP:0011876)1.76668337
154Hematochezia (HP:0002573)1.75243702
155Abnormality of the duodenum (HP:0002246)1.74805478
156Nephroblastoma (Wilms tumor) (HP:0002667)1.73779500
157Abnormality of the renal cortex (HP:0011035)1.73524370
158Diminished motivation (HP:0000745)1.72631188
159Ectropion (HP:0000656)1.72238917
160Recurrent abscess formation (HP:0002722)1.72049574
161Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.72026536
162Cerebral hemorrhage (HP:0001342)1.71430771
163Thick nail (HP:0001805)1.70910467
164Absent radius (HP:0003974)1.70673258
165Gastrointestinal infarctions (HP:0005244)1.69985557
166Dyschromatopsia (HP:0007641)1.69654126
167Autoimmune thrombocytopenia (HP:0001973)1.69424772
168Optic neuritis (HP:0100653)1.69124226
169Retrobulbar optic neuritis (HP:0100654)1.69124226
170Nonprogressive disorder (HP:0003680)1.68474268
171Irregular epiphyses (HP:0010582)1.68081200
172Microtia (HP:0008551)1.67666024
173Bone marrow hypocellularity (HP:0005528)1.66749666
174Abnormality of the hepatic vasculature (HP:0006707)1.66458547
175Abnormal drinking behavior (HP:0030082)1.64787116
176Polydipsia (HP:0001959)1.64787116
177Aplasia/Hypoplasia of the tibia (HP:0005772)1.64204044
178Chin dimple (HP:0010751)1.64013601
179Aplasia involving forearm bones (HP:0009822)1.63331354
180Absent forearm bone (HP:0003953)1.63331354
181Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.63243508
182Abnormality of the renal medulla (HP:0100957)1.62832906
183Aplasia/hypoplasia of the uterus (HP:0008684)1.61583687
184Abnormality of the basal ganglia (HP:0002134)1.61249282
185Genital tract atresia (HP:0001827)1.61147623
186Vaginal atresia (HP:0000148)1.61083325
187Abnormality of DNA repair (HP:0003254)1.60679740
188Embryonal renal neoplasm (HP:0011794)1.59192569
189Posterior embryotoxon (HP:0000627)1.58704958
190Decreased electroretinogram (ERG) amplitude (HP:0000654)1.57873742
191Nephronophthisis (HP:0000090)1.57290393
192Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.56902255
193Apathy (HP:0000741)1.56410089
194Decreased circulating renin level (HP:0003351)1.56363014
195Gingival bleeding (HP:0000225)1.56171396

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS17.53085172
2LATS25.45148371
3STK38L5.16637725
4MAP3K63.68296150
5ERBB43.62713456
6PNCK3.00457752
7STK32.61819431
8MAP4K22.53482150
9TAOK32.38204696
10MUSK2.36100190
11CDC72.28703960
12PLK42.28090511
13ADRBK22.21724298
14CDK82.07742286
15MET2.05831565
16MST42.01298659
17CASK1.91184447
18KSR21.89193494
19MAP3K131.86427895
20EPHA41.85038616
21TTK1.83875220
22STK381.81649560
23TNIK1.80692969
24PLK21.79550840
25PINK11.79267579
26GRK11.78636830
27EIF2AK11.76300619
28WNK31.74304761
29STK391.69012763
30OXSR11.67870658
31RAF11.65562087
32PTK2B1.61169361
33ABL21.54871674
34TAOK11.54421494
35CHEK21.53695348
36PDK21.51193449
37NTRK31.49665762
38EPHB21.49545995
39MST1R1.48853044
40NUAK11.47225494
41CSF1R1.45422054
42MAP3K91.43663255
43BRAF1.40396111
44MELK1.35783615
45MAP3K121.34763699
46CAMKK21.32298720
47FER1.23848111
48ERBB31.18536399
49MAPK131.15440946
50MKNK21.15392513
51PRKCE1.12709702
52CDK121.12031155
53EEF2K1.09640832
54TGFBR11.08506733
55SRPK11.07773182
56FGR1.07205430
57MOS1.04557147
58CDK91.03597797
59TGFBR21.03020249
60PAK60.99287579
61NEK20.98855283
62DMPK0.97791987
63EIF2AK30.97004710
64DYRK20.96832301
65TEC0.96469562
66PLK10.96228656
67PRKD30.92745192
68CAMK1D0.91687420
69YES10.90599187
70CSNK1G30.86604165
71MAP3K40.81634622
72MYLK0.80741909
73MAP2K70.79834479
74CDK30.79573049
75MAP3K20.79239591
76JAK30.79142269
77PAK30.78702302
78BLK0.78405298
79PRKAA20.78306308
80DAPK20.77315446
81STK240.77281008
82ARAF0.76456116
83MAPKAPK30.76068507
84FLT30.75360021
85ERBB20.75233436
86PRKCG0.74166342
87BMX0.73505110
88NEK60.72485958
89ABL10.72173160
90ADRBK10.71153015
91TRPM70.68574135
92BMPR20.68465991
93AURKB0.68461081
94KSR10.68355897
95IGF1R0.67552300
96PBK0.67288039
97ATM0.65666478
98MAPKAPK50.65665092
99CAMK2A0.65454522
100MKNK10.64433934
101GRK50.64157299
102TRIM280.64018939
103RIPK40.62824386
104PDGFRB0.61733568
105PRKD20.60764491
106CAMK2D0.58922843
107MATK0.58295621
108STK100.57770351
109WNK40.56549873
110BMPR1B0.55722740
111ACVR1B0.55361545
112GRK70.53106611
113PRKAA10.52374031
114CHEK10.52130344
115IRAK10.51932817
116CDK70.51812068
117PLK30.48765121
118CSNK1G10.48434142
119MINK10.48228539
120EPHA30.48207420
121EIF2AK20.47786163
122NEK10.47450269
123TYRO30.46926918
124CSK0.46709901
125TIE10.46621834
126MAP2K10.46105849
127FRK0.45799844
128PKN10.44564855
129MARK20.44447956
130BCR0.43965564
131VRK10.43645895
132CAMK2B0.43435381
133NEK90.43030689
134NLK0.42839565
135BRSK20.42304960
136MAP3K50.41980600
137PRKG10.41597498
138ROCK20.41503266
139SGK20.41439221
140MAP3K80.41192795
141MAPK100.38981094
142CAMK1G0.38191805
143CSNK1A10.37405984
144ILK0.36850844
145PRKACG0.36512618
146CAMK10.35201146
147CHUK0.34294306
148MAP2K40.32223093
149AURKA0.31666541
150CSNK1G20.31607424
151CDK10.30749707
152STK40.29596742
153MAPK110.29467522
154NTRK20.29038041
155RET0.28750207
156JAK20.28068581
157ATR0.25577840
158CDK20.25018314
159CDK40.23429041
160CSNK1D0.22041399
161PIM10.21603075
162TYK20.21526410
163HIPK20.19222651
164IKBKE0.18475408
165JAK10.18388487
166PIK3CA0.17545015
167KIT0.17471961
168AKT10.17408947
169CSNK1A1L0.17246391
170ZAK0.15051456

Predicted pathways (KEGG)

RankGene SetZ-score
1Cell cycle_Homo sapiens_hsa041103.42010406
2Basal transcription factors_Homo sapiens_hsa030223.25326309
3Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006033.10415101
4Fanconi anemia pathway_Homo sapiens_hsa034602.97053573
5RNA degradation_Homo sapiens_hsa030182.81060874
6Sulfur metabolism_Homo sapiens_hsa009202.74063169
7Nitrogen metabolism_Homo sapiens_hsa009102.73434301
8Vitamin B6 metabolism_Homo sapiens_hsa007502.73165435
9Homologous recombination_Homo sapiens_hsa034402.61884476
10Ovarian steroidogenesis_Homo sapiens_hsa049132.49659042
11Pancreatic cancer_Homo sapiens_hsa052122.21109019
12Other glycan degradation_Homo sapiens_hsa005112.20436024
13Circadian rhythm_Homo sapiens_hsa047102.13019375
14Glycerolipid metabolism_Homo sapiens_hsa005612.07354270
15RNA polymerase_Homo sapiens_hsa030201.94930209
16p53 signaling pathway_Homo sapiens_hsa041151.90720568
17TGF-beta signaling pathway_Homo sapiens_hsa043501.89546669
18Collecting duct acid secretion_Homo sapiens_hsa049661.87418540
19Ether lipid metabolism_Homo sapiens_hsa005651.81044772
20Primary bile acid biosynthesis_Homo sapiens_hsa001201.79993327
21Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.79244549
22Histidine metabolism_Homo sapiens_hsa003401.78575890
23Fatty acid elongation_Homo sapiens_hsa000621.70141081
24Asthma_Homo sapiens_hsa053101.69331678
25beta-Alanine metabolism_Homo sapiens_hsa004101.66112126
26Morphine addiction_Homo sapiens_hsa050321.64540913
27Fatty acid biosynthesis_Homo sapiens_hsa000611.60347644
28MicroRNAs in cancer_Homo sapiens_hsa052061.59737216
29Lysosome_Homo sapiens_hsa041421.59474479
30PPAR signaling pathway_Homo sapiens_hsa033201.58923026
31alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.58196507
32Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.55642265
33Linoleic acid metabolism_Homo sapiens_hsa005911.55547590
34Non-homologous end-joining_Homo sapiens_hsa034501.55001726
35Mineral absorption_Homo sapiens_hsa049781.52851136
36Propanoate metabolism_Homo sapiens_hsa006401.51876515
37Dorso-ventral axis formation_Homo sapiens_hsa043201.49617525
38Prolactin signaling pathway_Homo sapiens_hsa049171.47901696
39Glutamatergic synapse_Homo sapiens_hsa047241.45913500
40Protein export_Homo sapiens_hsa030601.42434359
41Glycosaminoglycan degradation_Homo sapiens_hsa005311.41859322
42Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.37459249
43Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.35268891
44Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.34425313
45Nicotine addiction_Homo sapiens_hsa050331.29378317
46Oocyte meiosis_Homo sapiens_hsa041141.27720512
47RNA transport_Homo sapiens_hsa030131.25886649
48Choline metabolism in cancer_Homo sapiens_hsa052311.22652403
49Lysine degradation_Homo sapiens_hsa003101.22477635
50Phagosome_Homo sapiens_hsa041451.20118924
51Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.18581129
52Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.18240878
53Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.18141410
54Circadian entrainment_Homo sapiens_hsa047131.17833832
55Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.14890765
56GnRH signaling pathway_Homo sapiens_hsa049121.14107831
57SNARE interactions in vesicular transport_Homo sapiens_hsa041301.13565482
58Tryptophan metabolism_Homo sapiens_hsa003801.13466065
59Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.11666035
60Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.09578847
61Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.09515413
62Colorectal cancer_Homo sapiens_hsa052101.09333373
63Renal cell carcinoma_Homo sapiens_hsa052111.09121216
64GABAergic synapse_Homo sapiens_hsa047271.08838023
65Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.08559627
66Fatty acid metabolism_Homo sapiens_hsa012121.06017126
67Pentose phosphate pathway_Homo sapiens_hsa000301.03568834
68Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.01558414
69Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.00794474
70Phototransduction_Homo sapiens_hsa047440.98243566
71Herpes simplex infection_Homo sapiens_hsa051680.96310443
72Pancreatic secretion_Homo sapiens_hsa049720.96184304
73Salivary secretion_Homo sapiens_hsa049700.94782249
74Small cell lung cancer_Homo sapiens_hsa052220.94393411
75Hepatitis B_Homo sapiens_hsa051610.91793490
76Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.91467712
77ECM-receptor interaction_Homo sapiens_hsa045120.90427196
78Steroid hormone biosynthesis_Homo sapiens_hsa001400.88074933
79mRNA surveillance pathway_Homo sapiens_hsa030150.87852093
80Gastric acid secretion_Homo sapiens_hsa049710.87636450
81Malaria_Homo sapiens_hsa051440.86703121
82FoxO signaling pathway_Homo sapiens_hsa040680.86654607
83Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.86359779
84NF-kappa B signaling pathway_Homo sapiens_hsa040640.86080131
85Nucleotide excision repair_Homo sapiens_hsa034200.85617930
86Glycerophospholipid metabolism_Homo sapiens_hsa005640.84889339
87Ras signaling pathway_Homo sapiens_hsa040140.83437795
88Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.83270364
89Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.82422842
90Prostate cancer_Homo sapiens_hsa052150.82362075
91Inositol phosphate metabolism_Homo sapiens_hsa005620.80251476
92Chronic myeloid leukemia_Homo sapiens_hsa052200.79741561
93NOD-like receptor signaling pathway_Homo sapiens_hsa046210.79643612
94Adherens junction_Homo sapiens_hsa045200.79593363
95Renin secretion_Homo sapiens_hsa049240.78229625
96Thyroid cancer_Homo sapiens_hsa052160.78117530
97Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.77836353
98Arachidonic acid metabolism_Homo sapiens_hsa005900.77536390
99Hematopoietic cell lineage_Homo sapiens_hsa046400.76079902
100Taste transduction_Homo sapiens_hsa047420.76009587
101Vascular smooth muscle contraction_Homo sapiens_hsa042700.75456044
102ErbB signaling pathway_Homo sapiens_hsa040120.75165308
103TNF signaling pathway_Homo sapiens_hsa046680.73277865
104Fat digestion and absorption_Homo sapiens_hsa049750.72279933
105Endometrial cancer_Homo sapiens_hsa052130.71507486
106Influenza A_Homo sapiens_hsa051640.70856826
107Bile secretion_Homo sapiens_hsa049760.70463652
108Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.69059425
109Purine metabolism_Homo sapiens_hsa002300.67977866
110Renin-angiotensin system_Homo sapiens_hsa046140.67784323
111Chemical carcinogenesis_Homo sapiens_hsa052040.67540748
112Jak-STAT signaling pathway_Homo sapiens_hsa046300.67227393
113Non-small cell lung cancer_Homo sapiens_hsa052230.66745722
114Melanoma_Homo sapiens_hsa052180.65870809
115Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.65065218
116Dopaminergic synapse_Homo sapiens_hsa047280.64628911
117Base excision repair_Homo sapiens_hsa034100.63966719
118Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.63493073
119Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.62833282
120Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.62350579
121Longevity regulating pathway - mammal_Homo sapiens_hsa042110.61900807
122Hippo signaling pathway_Homo sapiens_hsa043900.60614657
123Thyroid hormone signaling pathway_Homo sapiens_hsa049190.60217197
124Shigellosis_Homo sapiens_hsa051310.59760460
125Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.59288736
126Peroxisome_Homo sapiens_hsa041460.59052227
127Phospholipase D signaling pathway_Homo sapiens_hsa040720.58485704
128mTOR signaling pathway_Homo sapiens_hsa041500.57625069
129* Sphingolipid metabolism_Homo sapiens_hsa006000.57426980
130Transcriptional misregulation in cancer_Homo sapiens_hsa052020.57364750
131Mismatch repair_Homo sapiens_hsa034300.55932143
132Phosphatidylinositol signaling system_Homo sapiens_hsa040700.55108877
133Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.54134383
134Sphingolipid signaling pathway_Homo sapiens_hsa040710.53921337
135Chemokine signaling pathway_Homo sapiens_hsa040620.53796939
136Leishmaniasis_Homo sapiens_hsa051400.53774582
137Intestinal immune network for IgA production_Homo sapiens_hsa046720.53580043
138Olfactory transduction_Homo sapiens_hsa047400.53285480
139Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.52637619
140MAPK signaling pathway_Homo sapiens_hsa040100.51396253
141Regulation of actin cytoskeleton_Homo sapiens_hsa048100.51161642
142VEGF signaling pathway_Homo sapiens_hsa043700.48965887
143Insulin secretion_Homo sapiens_hsa049110.46988478
144Staphylococcus aureus infection_Homo sapiens_hsa051500.45316615
145Fatty acid degradation_Homo sapiens_hsa000710.45221005
146Selenocompound metabolism_Homo sapiens_hsa004500.45078504
147Tuberculosis_Homo sapiens_hsa051520.43880879
148Long-term depression_Homo sapiens_hsa047300.43356656
149Toxoplasmosis_Homo sapiens_hsa051450.42966187
150HTLV-I infection_Homo sapiens_hsa051660.42761517
151Pyruvate metabolism_Homo sapiens_hsa006200.42246730
152Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.42244164
153Steroid biosynthesis_Homo sapiens_hsa001000.41869237
154cAMP signaling pathway_Homo sapiens_hsa040240.41813753
155Synaptic vesicle cycle_Homo sapiens_hsa047210.41649409
156Pyrimidine metabolism_Homo sapiens_hsa002400.41521298
157ABC transporters_Homo sapiens_hsa020100.41477124
158Pathways in cancer_Homo sapiens_hsa052000.41359971
159Rheumatoid arthritis_Homo sapiens_hsa053230.38882843
160Serotonergic synapse_Homo sapiens_hsa047260.38076798
161Apoptosis_Homo sapiens_hsa042100.37525035
162Oxidative phosphorylation_Homo sapiens_hsa001900.37016897
163Gap junction_Homo sapiens_hsa045400.37008561
164Platelet activation_Homo sapiens_hsa046110.36282200
165Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.36113984
166RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.35907751
167Cholinergic synapse_Homo sapiens_hsa047250.35825871
168Wnt signaling pathway_Homo sapiens_hsa043100.34983525
169Bladder cancer_Homo sapiens_hsa052190.34668320
170Measles_Homo sapiens_hsa051620.34451650
171Glioma_Homo sapiens_hsa052140.33727200
172Viral carcinogenesis_Homo sapiens_hsa052030.33661566
173Rap1 signaling pathway_Homo sapiens_hsa040150.31734643

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