ACIN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Apoptosis is defined by several morphologic nuclear changes, including chromatin condensation and nuclear fragmentation. This gene encodes a nuclear protein that induces apoptotic chromatin condensation after activation by caspase-3, without inducing DNA fragmentation. This protein has also been shown to be a component of a splicing-dependent multiprotein exon junction complex (EJC) that is deposited at splice junctions on mRNAs, as a consequence of pre-mRNA splicing. It may thus be involved in mRNA metabolism associated with splicing. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pre-miRNA processing (GO:0031054)4.89378498
2regulation of histone H3-K27 methylation (GO:0061085)4.24124114
3negative regulation of erythrocyte differentiation (GO:0045647)4.23157430
4negative regulation of histone methylation (GO:0031061)4.02148757
5nuclear pore complex assembly (GO:0051292)3.99865287
6heterochromatin organization (GO:0070828)3.94894987
7mRNA stabilization (GO:0048255)3.91557799
8RNA stabilization (GO:0043489)3.91557799
9mitotic sister chromatid cohesion (GO:0007064)3.81143392
10positive regulation of histone deacetylation (GO:0031065)3.78984194
11mannose metabolic process (GO:0006013)3.73363051
12nuclear pore organization (GO:0006999)3.68246441
13regulation of RNA export from nucleus (GO:0046831)3.51438703
14regulation of histone H3-K9 methylation (GO:0051570)3.49985053
15peptidyl-lysine dimethylation (GO:0018027)3.49863086
16embryonic process involved in female pregnancy (GO:0060136)3.43847212
17protein-DNA complex disassembly (GO:0032986)3.41392468
18nucleosome disassembly (GO:0006337)3.41392468
19DNA unwinding involved in DNA replication (GO:0006268)3.39947864
20histone H3-K4 methylation (GO:0051568)3.34216372
21focal adhesion assembly (GO:0048041)3.32384864
22cell-substrate adherens junction assembly (GO:0007045)3.32384864
23positive thymic T cell selection (GO:0045059)3.32108667
24regulation of translational fidelity (GO:0006450)3.31911540
25protein localization to kinetochore (GO:0034501)3.31125688
26* negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.30887215
27adherens junction assembly (GO:0034333)3.30816624
28cytoplasmic mRNA processing body assembly (GO:0033962)3.29546457
29glucocorticoid receptor signaling pathway (GO:0042921)3.29487043
30histone H3-K4 trimethylation (GO:0080182)3.29356081
31positive regulation of RNA splicing (GO:0033120)3.28137334
32cellular response to epidermal growth factor stimulus (GO:0071364)3.26476380
33intracellular estrogen receptor signaling pathway (GO:0030520)3.25598704
34regulation of NFAT protein import into nucleus (GO:0051532)3.24069517
35dosage compensation (GO:0007549)3.19921863
36positive regulation of gene expression, epigenetic (GO:0045815)3.17278415
37pore complex assembly (GO:0046931)3.16564867
38DNA duplex unwinding (GO:0032508)3.16233739
39sister chromatid segregation (GO:0000819)3.14744581
40spliceosomal tri-snRNP complex assembly (GO:0000244)3.13660936
41DNA geometric change (GO:0032392)3.13261561
42NLS-bearing protein import into nucleus (GO:0006607)3.12698657
43chromatin assembly (GO:0031497)3.12628665
44alternative mRNA splicing, via spliceosome (GO:0000380)3.09821065
45regulation of sister chromatid cohesion (GO:0007063)3.06090325
46regulation of mRNA stability (GO:0043488)3.04232699
47regulation of gamma-delta T cell differentiation (GO:0045586)3.03261335
48negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.02890822
49negative regulation of cell killing (GO:0031342)3.02890822
50histone H3-K9 methylation (GO:0051567)3.02553511
51chromatin silencing (GO:0006342)2.99935227
52response to epidermal growth factor (GO:0070849)2.99716626
53histone H3-K36 demethylation (GO:0070544)2.98455487
54* negative regulation of RNA splicing (GO:0033119)2.98284490
55protein localization to chromosome, centromeric region (GO:0071459)2.96453557
56positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.96407289
573-UTR-mediated mRNA stabilization (GO:0070935)2.93275325
58Golgi transport vesicle coating (GO:0048200)2.89833180
59COPI coating of Golgi vesicle (GO:0048205)2.89833180
60histone lysine methylation (GO:0034968)2.89169397
61regulation of histone H3-K4 methylation (GO:0051569)2.88493476
62mRNA splice site selection (GO:0006376)2.87590029
63* negative regulation of mRNA processing (GO:0050686)2.87126995
64histone H4-K16 acetylation (GO:0043984)2.86480818
65regulation of hippo signaling (GO:0035330)2.85114333
66histone H3-K9 modification (GO:0061647)2.84405487
67positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.84062259
68negative regulation of gene expression, epigenetic (GO:0045814)2.84035089
69peptidyl-lysine trimethylation (GO:0018023)2.83523248
70regulation of RNA stability (GO:0043487)2.83226245
71mitotic chromosome condensation (GO:0007076)2.83001800
72mitotic sister chromatid segregation (GO:0000070)2.82257637
73positive regulation of gamma-delta T cell activation (GO:0046645)2.81827809
74regulation of posttranscriptional gene silencing (GO:0060147)2.81803287
75regulation of gene silencing by miRNA (GO:0060964)2.81803287
76regulation of gene silencing by RNA (GO:0060966)2.81803287
77regulation of nucleobase-containing compound transport (GO:0032239)2.81281761
78gene silencing (GO:0016458)2.81106677
79thymic T cell selection (GO:0045061)2.80916450
80trophectodermal cell differentiation (GO:0001829)2.80192406
81regulation of ARF GTPase activity (GO:0032312)2.78272768
82* negative regulation of mRNA metabolic process (GO:1903312)2.77519308
83positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.77099344
84positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.77099344
85positive regulation of mitotic sister chromatid separation (GO:1901970)2.77099344
86histone H3-K9 demethylation (GO:0033169)2.74593573
87insulin-like growth factor receptor signaling pathway (GO:0048009)2.73389010
88pinocytosis (GO:0006907)2.70930980
89regulation of gamma-delta T cell activation (GO:0046643)2.69415425
90cell-substrate junction assembly (GO:0007044)2.68582789
91regulation of mammary gland epithelial cell proliferation (GO:0033599)2.68465744
92histone H4-K12 acetylation (GO:0043983)2.67741393
93histone methylation (GO:0016571)2.66526429
94positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.66226709
95cellular hyperosmotic response (GO:0071474)2.65275126
96corticosteroid receptor signaling pathway (GO:0031958)2.65190704
97histone lysine demethylation (GO:0070076)2.64505390
98negative regulation of cell size (GO:0045792)2.64093949
99activation of Rac GTPase activity (GO:0032863)2.63478227
100regulation of histone methylation (GO:0031060)2.62966521
101positive T cell selection (GO:0043368)2.62561257
102mitotic nuclear envelope disassembly (GO:0007077)2.61872093
103regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.61450505
104DNA topological change (GO:0006265)2.60885992
105cytoskeletal anchoring at plasma membrane (GO:0007016)2.60818042
106positive regulation of protein deacetylation (GO:0090312)2.60307621
107regulation of extracellular matrix disassembly (GO:0010715)2.60134396
108poly(A)+ mRNA export from nucleus (GO:0016973)2.60121257
109negative regulation of histone modification (GO:0031057)2.60025713
110positive regulation of chromosome segregation (GO:0051984)2.59961943
111planar cell polarity pathway involved in neural tube closure (GO:0090179)2.59651672
112histone H4 deacetylation (GO:0070933)2.59164868
113regulation of glucose import in response to insulin stimulus (GO:2001273)2.58911856
114response to laminar fluid shear stress (GO:0034616)2.58565310
115histone H4-K8 acetylation (GO:0043982)2.56962444
116histone H4-K5 acetylation (GO:0043981)2.56962444
117positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.56831146
118regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.56609958
119negative regulation of fatty acid transport (GO:2000192)2.55994944
120positive regulation of Cdc42 GTPase activity (GO:0043089)2.55808935
121regulation of chromatin binding (GO:0035561)2.55673514
122positive regulation by host of viral transcription (GO:0043923)2.55433871
123peptidyl-lysine methylation (GO:0018022)2.54749073
124histone H2A monoubiquitination (GO:0035518)2.54732428
125maternal placenta development (GO:0001893)2.54404376
126histone demethylation (GO:0016577)2.54308356
127basement membrane organization (GO:0071711)2.54239666
128protein localization to endosome (GO:0036010)2.53413643
129protein dealkylation (GO:0008214)2.52168112
130protein demethylation (GO:0006482)2.52168112
131gene silencing by RNA (GO:0031047)2.50193152
132negative regulation of myotube differentiation (GO:0010832)2.49639891
133apoptotic process involved in morphogenesis (GO:0060561)2.49244783
134protein export from nucleus (GO:0006611)2.49045983
135response to muramyl dipeptide (GO:0032495)2.48003481
136modulation by symbiont of host cellular process (GO:0044068)2.47143132
137establishment of apical/basal cell polarity (GO:0035089)2.46827520
138stress granule assembly (GO:0034063)2.46462138
139mitotic G1 DNA damage checkpoint (GO:0031571)2.46138995
140nuclear envelope disassembly (GO:0051081)2.45483206
141membrane disassembly (GO:0030397)2.45483206
142regulation of translation, ncRNA-mediated (GO:0045974)2.44125247
143modulation by virus of host process (GO:0019054)2.42405649
144regulation of apoptotic cell clearance (GO:2000425)2.42229116
145semaphorin-plexin signaling pathway (GO:0071526)2.41794494
146activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.38304393
147regulation of cholesterol homeostasis (GO:2000188)2.37404783
148embryonic eye morphogenesis (GO:0048048)2.36442941
149embryonic camera-type eye morphogenesis (GO:0048596)2.36001989
150positive regulation of nuclease activity (GO:0032075)2.33655326
151regulation of early endosome to late endosome transport (GO:2000641)2.33378948
152retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.32713510
153regulation of type I interferon-mediated signaling pathway (GO:0060338)2.31825608
154regulation of ARF protein signal transduction (GO:0032012)2.30359738
155positive regulation of blood vessel endothelial cell migration (GO:0043536)2.28346208
156cellular response to virus (GO:0098586)2.27543886
157epithelial cell differentiation involved in prostate gland development (GO:0060742)2.27050492
158positive regulation of extracellular matrix organization (GO:1903055)2.25034160
159regulation of extracellular matrix organization (GO:1903053)2.23848330
160stress fiber assembly (GO:0043149)2.23150113

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.96648017
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.82956186
3MYC_22102868_ChIP-Seq_BL_Human4.26323496
4EGR1_19374776_ChIP-ChIP_THP-1_Human4.15278048
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.28715680
6VDR_21846776_ChIP-Seq_THP-1_Human2.97816486
7TCF7_22412390_ChIP-Seq_EML_Mouse2.66602552
8KDM2B_26808549_Chip-Seq_DND41_Human2.53809625
9STAT6_21828071_ChIP-Seq_BEAS2B_Human2.51912615
10KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.43116881
11E2F4_17652178_ChIP-ChIP_JURKAT_Human2.35936404
12KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.35458681
13THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.28545554
14KDM2B_26808549_Chip-Seq_SUP-B15_Human2.20920039
15CIITA_25753668_ChIP-Seq_RAJI_Human2.12842319
16FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.08292200
17UTX_26944678_Chip-Seq_JUKART_Human2.05661186
18NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.02318412
19TP63_19390658_ChIP-ChIP_HaCaT_Human1.98587345
20* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.95696523
21MAF_26560356_Chip-Seq_TH1_Human1.95375168
22TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.92120085
23ELK3_25401928_ChIP-Seq_HUVEC_Human1.90589389
24RARG_19884340_ChIP-ChIP_MEFs_Mouse1.90037990
25* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.85969865
26CLOCK_20551151_ChIP-Seq_293T_Human1.83074656
27EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.81078138
28ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.79914394
29KDM2B_26808549_Chip-Seq_JURKAT_Human1.77418931
30SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.72213193
31* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.68569241
32* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.65397474
33FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.64512009
34SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.56990402
35E2F1_21310950_ChIP-Seq_MCF-7_Human1.55814525
36TP63_17297297_ChIP-ChIP_HaCaT_Human1.53966603
37DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.53182720
38TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.51916232
39VDR_24763502_ChIP-Seq_THP-1_Human1.51616887
40KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.50938864
41NCOR1_26117541_ChIP-Seq_K562_Human1.46441461
42MYB_26560356_Chip-Seq_TH1_Human1.45987527
43ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.45926978
44SCL_19346495_ChIP-Seq_HPC-7_Human1.45286481
45LXR_22292898_ChIP-Seq_THP-1_Human1.45117369
46* MYC_19079543_ChIP-ChIP_MESCs_Mouse1.44722256
47STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.43059795
48FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.42604395
49ZNF263_19887448_ChIP-Seq_K562_Human1.42109863
50EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.40397650
51* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.38774415
52MAF_26560356_Chip-Seq_TH2_Human1.38141520
53E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.37860090
54MYB_26560356_Chip-Seq_TH2_Human1.37180036
55P300_27058665_Chip-Seq_ZR-75-30cells_Human1.36434728
56VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.32879924
57KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.32643359
58ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.32567383
59KDM2B_26808549_Chip-Seq_K562_Human1.31658470
60BRD4_27068464_Chip-Seq_AML-cells_Mouse1.29072307
61EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.28561126
62NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.28221527
63RACK7_27058665_Chip-Seq_MCF-7_Human1.27948224
64PKCTHETA_26484144_Chip-Seq_BREAST_Human1.27195491
65ESR2_21235772_ChIP-Seq_MCF-7_Human1.26920672
66* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.26533287
67SMC4_20622854_ChIP-Seq_HELA_Human1.24211334
68DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.22412554
69RUNX1_22412390_ChIP-Seq_EML_Mouse1.22289938
70MYC_18555785_ChIP-Seq_MESCs_Mouse1.21089797
71KLF4_18555785_ChIP-Seq_MESCs_Mouse1.20474469
72KDM5A_27292631_Chip-Seq_BREAST_Human1.20469978
73GATA1_22383799_ChIP-Seq_G1ME_Mouse1.18665454
74MYB_21317192_ChIP-Seq_ERMYB_Mouse1.17291890
75HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.17055638
76SA1_27219007_Chip-Seq_ERYTHROID_Human1.14423229
77WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.13802854
78KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.13444913
79KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.13444913
80KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.13444913
81NANOG_21062744_ChIP-ChIP_HESCs_Human1.12135015
82* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.11451694
83CREB1_26743006_Chip-Seq_LNCaP_Human1.10919680
84SPI1_23127762_ChIP-Seq_K562_Human1.10710059
85SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.10503860
86RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.09996467
87TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.09574478
88MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.09342992
89ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.08730136
90GATA1_19941827_ChIP-Seq_MEL_Mouse1.08378790
91NFIB_24661679_ChIP-Seq_LUNG_Mouse1.07380298
92CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.05851132
93DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.05459734
94FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.05373293
95UBF1/2_26484160_Chip-Seq_HMECs_Human1.05143645
96MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.04910702
97* CHD1_26751641_Chip-Seq_LNCaP_Human1.04822049
98HIF1A_21447827_ChIP-Seq_MCF-7_Human1.04357925
99SALL1_21062744_ChIP-ChIP_HESCs_Human1.03878052
100TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.01597170
101STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.00733396
102* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.00708463
103GATA1_19941826_ChIP-Seq_K562_Human1.00220064
104TP53_22127205_ChIP-Seq_IMR90_Human1.00084502
105TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.99433997
106* XRN2_22483619_ChIP-Seq_HELA_Human0.99236419
107CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.98480320
108CTCF_27219007_Chip-Seq_ERYTHROID_Human0.98384176
109SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.98343716
110CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.97699113
111RUNX1_27514584_Chip-Seq_MCF-7_Human0.97033798
112ATF3_27146783_Chip-Seq_COLON_Human0.96165792
113GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96105061
114* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.95900537
115P68_20966046_ChIP-Seq_HELA_Human0.95537549
116TET1_21451524_ChIP-Seq_MESCs_Mouse0.95117099
117SOX2_27498859_Chip-Seq_STOMACH_Mouse0.94625732
118ERG_21242973_ChIP-ChIP_JURKAT_Human0.93766738
119SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.93416768
120STAT3_1855785_ChIP-Seq_MESCs_Mouse0.93207811
121* SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.91914007
122NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.91542636
123TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.90976675
124EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.90686331
125* GATA6_25053715_ChIP-Seq_YYC3_Human0.90452660
126TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.90235302
127POU5F1_16518401_ChIP-PET_MESCs_Mouse0.89578288
128ELF1_20517297_ChIP-Seq_JURKAT_Human0.88793762
129* KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.88246986
130UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.88175161

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005076_abnormal_cell_differentiation3.18395306
2MP0009278_abnormal_bone_marrow2.88456501
3MP0005451_abnormal_body_composition2.84107602
4MP0003705_abnormal_hypodermis_morpholog2.69376086
5MP0010352_gastrointestinal_tract_polyps2.67558843
6MP0003111_abnormal_nucleus_morphology2.55701270
7MP0002396_abnormal_hematopoietic_system2.27519943
8MP0003300_gastrointestinal_ulcer2.23437893
9MP0003172_abnormal_lysosome_physiology2.19065248
10MP0010094_abnormal_chromosome_stability2.18105405
11MP0008057_abnormal_DNA_replication2.17670269
12MP0000569_abnormal_digit_pigmentation2.16835604
13MP0005409_darkened_coat_color2.15047112
14MP0003077_abnormal_cell_cycle2.09885371
15MP0005058_abnormal_lysosome_morphology2.07516062
16MP0004808_abnormal_hematopoietic_stem2.00553393
17MP0003436_decreased_susceptibility_to1.89756955
18MP0010307_abnormal_tumor_latency1.86435832
19MP0003303_peritoneal_inflammation1.84522139
20MP0004197_abnormal_fetal_growth/weight/1.84008360
21MP0008260_abnormal_autophagy1.81357207
22MP0001730_embryonic_growth_arrest1.79982894
23MP0003693_abnormal_embryo_hatching1.79823230
24MP0003787_abnormal_imprinting1.76936949
25MP0008961_abnormal_basal_metabolism1.75932356
26MP0008438_abnormal_cutaneous_collagen1.74389347
27MP0000350_abnormal_cell_proliferation1.71879495
28MP0001849_ear_inflammation1.71520650
29MP0004957_abnormal_blastocyst_morpholog1.69572550
30MP0002084_abnormal_developmental_patter1.69513784
31MP0003566_abnormal_cell_adhesion1.69197742
32MP0002009_preneoplasia1.66801825
33MP0001672_abnormal_embryogenesis/_devel1.64035026
34MP0005380_embryogenesis_phenotype1.64035026
35MP0000733_abnormal_muscle_development1.64033067
36MP0003763_abnormal_thymus_physiology1.63113863
37MP0004858_abnormal_nervous_system1.61322792
38MP0000703_abnormal_thymus_morphology1.61070005
39MP0003984_embryonic_growth_retardation1.56703703
40MP0002088_abnormal_embryonic_growth/wei1.55827416
41MP0002086_abnormal_extraembryonic_tissu1.54950665
42MP0002085_abnormal_embryonic_tissue1.52090895
43MP0003121_genomic_imprinting1.45859439
44MP0001348_abnormal_lacrimal_gland1.45314011
45MP0002089_abnormal_postnatal_growth/wei1.42372558
46MP0001697_abnormal_embryo_size1.39650354
47MP0009053_abnormal_anal_canal1.37740730
48MP0001545_abnormal_hematopoietic_system1.37656300
49MP0005397_hematopoietic_system_phenotyp1.37656300
50MP0002398_abnormal_bone_marrow1.36791660
51MP0008007_abnormal_cellular_replicative1.36102884
52MP0000858_altered_metastatic_potential1.34963674
53MP0004233_abnormal_muscle_weight1.34949403
54MP0002653_abnormal_ependyma_morphology1.32895255
55MP0003890_abnormal_embryonic-extraembry1.32885236
56MP0008877_abnormal_DNA_methylation1.30755279
57MP0010030_abnormal_orbit_morphology1.28783483
58MP0000428_abnormal_craniofacial_morphol1.28366376
59MP0000537_abnormal_urethra_morphology1.27873326
60MP0002080_prenatal_lethality1.26762415
61MP0003115_abnormal_respiratory_system1.26306190
62MP0000678_abnormal_parathyroid_gland1.24984425
63MP0000003_abnormal_adipose_tissue1.24525430
64MP0002166_altered_tumor_susceptibility1.24438689
65MP0000685_abnormal_immune_system1.24114745
66MP0009703_decreased_birth_body1.23421011
67MP0003119_abnormal_digestive_system1.23410325
68MP0003567_abnormal_fetal_cardiomyocyte1.21933847
69MP0002925_abnormal_cardiovascular_devel1.21619321
70MP0005375_adipose_tissue_phenotype1.20336406
71MP0005621_abnormal_cell_physiology1.18594731
72MP0002249_abnormal_larynx_morphology1.17696023
73MP0004264_abnormal_extraembryonic_tissu1.14861713
74MP0010234_abnormal_vibrissa_follicle1.14705192
75MP0003935_abnormal_craniofacial_develop1.13639626
76MP0009672_abnormal_birth_weight1.13436904
77MP0002722_abnormal_immune_system1.12283565
78MP0003123_paternal_imprinting1.11693690
79MP0001800_abnormal_humoral_immune1.11592965
80MP0002697_abnormal_eye_size1.11550457
81MP0005257_abnormal_intraocular_pressure1.10312112
82MP0002877_abnormal_melanocyte_morpholog1.09694810
83MP0004185_abnormal_adipocyte_glucose1.08439841
84MP0005023_abnormal_wound_healing1.08201180
85MP0003283_abnormal_digestive_organ1.06932360
86MP0000490_abnormal_crypts_of1.06629040
87MP0002998_abnormal_bone_remodeling1.03627818
88MP0010630_abnormal_cardiac_muscle1.02791730
89MP0003045_fibrosis1.02061053
90MP0000313_abnormal_cell_death1.01800806
91MP0002092_abnormal_eye_morphology1.01094623
92MP0000689_abnormal_spleen_morphology1.00815771
93MP0002019_abnormal_tumor_incidence1.00704897
94MP0000767_abnormal_smooth_muscle0.98511702
95MP0004272_abnormal_basement_membrane0.94810285
96MP0008058_abnormal_DNA_repair0.93914471
97MP0001915_intracranial_hemorrhage0.93438737
98MP0000716_abnormal_immune_system0.93292789
99MP0000432_abnormal_head_morphology0.92131713
100MP0001293_anophthalmia0.91649739
101MP0008770_decreased_survivor_rate0.90161884
102MP0000266_abnormal_heart_morphology0.88920382
103MP0001784_abnormal_fluid_regulation0.88684071
104MP0002060_abnormal_skin_morphology0.88482877
105MP0003191_abnormal_cellular_cholesterol0.88225598
106MP0002429_abnormal_blood_cell0.87477082
107MP0003385_abnormal_body_wall0.87319965
108MP0002405_respiratory_system_inflammati0.86628699
109MP0001873_stomach_inflammation0.85921050
110MP0003091_abnormal_cell_migration0.85287822
111MP0002006_tumorigenesis0.82940280
112MP0003828_pulmonary_edema0.82805845
113MP0005387_immune_system_phenotype0.82663867
114MP0001790_abnormal_immune_system0.82663867
115MP0001958_emphysema0.82095507
116MP0005174_abnormal_tail_pigmentation0.80317015
117MP0003279_aneurysm0.80113176
118MP0002796_impaired_skin_barrier0.79605722
119MP0002452_abnormal_antigen_presenting0.79382215
120MP0009333_abnormal_splenocyte_physiolog0.77829274
121MP0002420_abnormal_adaptive_immunity0.77541665
122MP0002419_abnormal_innate_immunity0.77442130
123MP0005623_abnormal_meninges_morphology0.77365822
124MP0010155_abnormal_intestine_physiology0.76355512
125MP0005666_abnormal_adipose_tissue0.76283128
126MP0004947_skin_inflammation0.76228399
127MP0005384_cellular_phenotype0.76088221
128MP0000477_abnormal_intestine_morphology0.76002758
129MP0001819_abnormal_immune_cell0.75926467
130MP0009931_abnormal_skin_appearance0.75802705
131MP0003329_amyloid_beta_deposits0.75779412
132MP0003453_abnormal_keratinocyte_physiol0.75567519
133MP0009384_cardiac_valve_regurgitation0.74764626
134MP0009840_abnormal_foam_cell0.74742752
135MP0002111_abnormal_tail_morphology0.74454406
136MP0003942_abnormal_urinary_system0.74420395
137MP0001614_abnormal_blood_vessel0.72111275
138MP0001851_eye_inflammation0.71701158
139MP0004087_abnormal_muscle_fiber0.70903612

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the fingertips (HP:0001211)3.90447426
2Hyperacusis (HP:0010780)3.88319793
3Protrusio acetabuli (HP:0003179)3.02104450
4Deep venous thrombosis (HP:0002625)2.91965429
5Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.91485909
6Short 4th metacarpal (HP:0010044)2.91485909
7Cerebral aneurysm (HP:0004944)2.91346951
8Flat acetabular roof (HP:0003180)2.89881737
9Broad face (HP:0000283)2.86607729
10Ependymoma (HP:0002888)2.74333204
11Renal duplication (HP:0000075)2.74157291
12Increased nuchal translucency (HP:0010880)2.72855354
13Volvulus (HP:0002580)2.71867002
14Obstructive sleep apnea (HP:0002870)2.69312548
15Macroorchidism (HP:0000053)2.60029675
16Elfin facies (HP:0004428)2.55747563
17Renovascular hypertension (HP:0100817)2.53975648
18Long eyelashes (HP:0000527)2.52467844
19Ulnar bowing (HP:0003031)2.41194057
20Abnormality of the astrocytes (HP:0100707)2.39419275
21Astrocytoma (HP:0009592)2.39419275
22Heterotopia (HP:0002282)2.38536071
23Supernumerary ribs (HP:0005815)2.27724266
24Shallow orbits (HP:0000586)2.27106707
25Pseudobulbar signs (HP:0002200)2.23647916
26Abnormality of the 4th metacarpal (HP:0010012)2.23593056
27Urethral obstruction (HP:0000796)2.21476358
28Thin bony cortex (HP:0002753)2.18900992
29Biconcave vertebral bodies (HP:0004586)2.17516080
30Deviation of the thumb (HP:0009603)2.16490462
31Metaphyseal cupping (HP:0003021)2.16395457
32Overriding aorta (HP:0002623)2.14527367
33Proximal placement of thumb (HP:0009623)2.14044048
34Selective tooth agenesis (HP:0001592)2.13401816
35Insomnia (HP:0100785)2.12888502
36Broad palm (HP:0001169)2.12648268
37Anal stenosis (HP:0002025)2.11840333
38Abnormality of the radial head (HP:0003995)2.11747812
39Skin tags (HP:0010609)2.10285478
40Abnormality of the distal phalanx of the thumb (HP:0009617)2.10239109
41Ankyloglossia (HP:0010296)2.09337133
42Malignant gastrointestinal tract tumors (HP:0006749)2.09199554
43Gastrointestinal carcinoma (HP:0002672)2.09199554
44Basal cell carcinoma (HP:0002671)2.07831748
45Hemorrhage of the eye (HP:0011885)2.06856855
46Trigonocephaly (HP:0000243)2.06808580
47High pitched voice (HP:0001620)2.06638296
48Abnormal number of incisors (HP:0011064)2.06305900
49Cervical subluxation (HP:0003308)2.06113094
50Dysmetric saccades (HP:0000641)2.04278546
51Prominent nose (HP:0000448)2.01039156
52Distal lower limb amyotrophy (HP:0008944)2.00854603
53Premature rupture of membranes (HP:0001788)2.00737857
54Medulloblastoma (HP:0002885)1.98429691
55Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.98362637
56Rib fusion (HP:0000902)1.98312885
57Abnormality of the thoracic spine (HP:0100711)1.97518194
58Broad thumb (HP:0011304)1.96799737
59Flat cornea (HP:0007720)1.95823735
60Bowel diverticulosis (HP:0005222)1.94880002
61Increased density of long bones (HP:0006392)1.93699611
62Pointed chin (HP:0000307)1.92647896
63Supernumerary bones of the axial skeleton (HP:0009144)1.92507681
64Obsessive-compulsive behavior (HP:0000722)1.92328310
65Vertebral arch anomaly (HP:0008438)1.91568738
66Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.91090583
67Ectopic kidney (HP:0000086)1.87336420
68Uterine leiomyosarcoma (HP:0002891)1.87219861
69Leiomyosarcoma (HP:0100243)1.87219861
70Increased connective tissue (HP:0009025)1.87062428
71Long palpebral fissure (HP:0000637)1.84803798
72Eczematoid dermatitis (HP:0000976)1.83296226
73Abnormality of the diencephalon (HP:0010662)1.80409017
74Sparse lateral eyebrow (HP:0005338)1.80123465
75Cutis marmorata (HP:0000965)1.79073287
76Transitional cell carcinoma of the bladder (HP:0006740)1.78509196
77Segmental peripheral demyelination/remyelination (HP:0003481)1.77712705
78Glioma (HP:0009733)1.77600193
79Bicuspid aortic valve (HP:0001647)1.77392734
80Abnormality of oral frenula (HP:0000190)1.77171348
81Thin ribs (HP:0000883)1.76444488
82Preauricular skin tag (HP:0000384)1.76048370
83Short phalanx of the thumb (HP:0009660)1.75748211
84Centrally nucleated skeletal muscle fibers (HP:0003687)1.75589993
85Vertebral compression fractures (HP:0002953)1.75375769
86Narrow palate (HP:0000189)1.75048442
87Spina bifida occulta (HP:0003298)1.74975748
88Rectal prolapse (HP:0002035)1.74357930
89Arnold-Chiari malformation (HP:0002308)1.73138670
90Subacute progressive viral hepatitis (HP:0006572)1.73037757
91Abnormal ossification of hand bones (HP:0005921)1.72832771
92Cupped ribs (HP:0000887)1.72046959
93Verrucae (HP:0200043)1.71597725
94Papilloma (HP:0012740)1.71597725
95Skull defect (HP:0001362)1.70919562
96Mitral regurgitation (HP:0001653)1.70157037
97Colitis (HP:0002583)1.69655105
98Recurrent viral infections (HP:0004429)1.68690647
99Neoplasm of the oral cavity (HP:0100649)1.68637734
100Neoplasm of striated muscle (HP:0009728)1.68440582
101Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.68365051
102Short 1st metacarpal (HP:0010034)1.68365051
103Mitral valve prolapse (HP:0001634)1.67496695
104Cellulitis (HP:0100658)1.67478427
105Deep palmar crease (HP:0006191)1.66901799
106Intestinal fistula (HP:0100819)1.66369565
107Syringomyelia (HP:0003396)1.66135690
108Spinal cord lesions (HP:0100561)1.66135690
109Arterial tortuosity (HP:0005116)1.66085691
110Bronchomalacia (HP:0002780)1.65978774
111Blue sclerae (HP:0000592)1.65885399
112Disproportionate tall stature (HP:0001519)1.65241241
113Abnormality of the humeroradial joint (HP:0100744)1.65047425
114Sandal gap (HP:0001852)1.65024214
115Broad phalanges of the hand (HP:0009768)1.64275481
116Bladder carcinoma (HP:0002862)1.64130553
117Bladder neoplasm (HP:0009725)1.64130553
118Persistence of primary teeth (HP:0006335)1.64017593
119Dislocated radial head (HP:0003083)1.63945472
120Dilatation of the ascending aorta (HP:0005111)1.63710011
121Aortic aneurysm (HP:0004942)1.63632566
122Advanced eruption of teeth (HP:0006288)1.63551071
123Abnormality of the intervertebral disk (HP:0005108)1.63085111
124Bladder diverticulum (HP:0000015)1.62679888
125Biliary tract neoplasm (HP:0100574)1.62322359
126Abnormality of the lower motor neuron (HP:0002366)1.61933378
127Distal upper limb amyotrophy (HP:0007149)1.61622752
128Upper limb amyotrophy (HP:0009129)1.61622752
129Gastrointestinal inflammation (HP:0004386)1.61586983
130Turricephaly (HP:0000262)1.60816327
131Abnormality of the calcaneus (HP:0008364)1.60244985
132Short 5th finger (HP:0009237)1.59917711
133Abnormality of carpal bone ossification (HP:0006257)1.59759407
134Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.59753535
135Aneurysm (HP:0002617)1.59560711
136Abnormality of the peritoneum (HP:0002585)1.59552484
137Patellar dislocation (HP:0002999)1.58845491
138Truncal obesity (HP:0001956)1.58075976
139Low anterior hairline (HP:0000294)1.57935250
140Abnormality of the acetabulum (HP:0003170)1.57683413
141Germ cell neoplasia (HP:0100728)1.57431822
142Abnormal delayed hypersensitivity skin test (HP:0002963)1.56890502
143Asymmetry of the thorax (HP:0001555)1.56646017
144Joint laxity (HP:0001388)1.56557535
145Limited elbow extension (HP:0001377)1.56520588
146Acute lymphatic leukemia (HP:0006721)1.56039986
147Ureteral stenosis (HP:0000071)1.55969792
148Abnormal vertebral ossification (HP:0100569)1.55919201
149T lymphocytopenia (HP:0005403)1.55637847
150Thick eyebrow (HP:0000574)1.55483096
151Polygenic inheritance (HP:0010982)1.55372044
152Missing ribs (HP:0000921)1.55361441
153Absent frontal sinuses (HP:0002688)1.55350551
154Viral hepatitis (HP:0006562)1.54984713
155Thoracic kyphosis (HP:0002942)1.54707250
156Achilles tendon contracture (HP:0001771)1.54524351
157Wide nose (HP:0000445)1.51578341
158Gingivitis (HP:0000230)1.50022790
159Abnormality of the Achilles tendon (HP:0005109)1.49009867
160Overlapping toe (HP:0001845)1.48658793
161Flared metaphyses (HP:0003015)1.47853466
162Premature skin wrinkling (HP:0100678)1.47571041
163Bowel incontinence (HP:0002607)1.46761945
164Vascular tortuosity (HP:0004948)1.46216991

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.61169839
2MAP3K104.15617056
3EEF2K3.90024794
4SMG13.31251854
5TRIB33.15740219
6PRPF4B2.91256507
7PKN22.79848682
8BRD42.36724826
9MAP4K12.26279233
10ICK2.23781050
11SIK22.22254782
12CDC72.18019794
13NEK22.02168284
14PTK61.84617981
15ALK1.66296607
16CAMK1G1.66007779
17STK101.64752784
18TTN1.57524703
19RIPK11.57326827
20MTOR1.52831216
21CAMK1D1.51489686
22MAP3K131.44442811
23CDK41.43134706
24CDK61.42179989
25RPS6KB21.40632513
26PDGFRA1.37858569
27RIPK41.33255857
28ERN11.25085768
29SIK11.23914537
30BMX1.23545150
31LATS11.22442646
32LRRK21.17160614
33KSR21.16253416
34PASK1.13358355
35TYRO31.10935116
36GRK61.09962702
37ATR1.05245511
38FGFR31.00054517
39IRAK30.99935960
40CHEK10.97512967
41CDK70.96202590
42MKNK20.94746459
43FGFR40.93507889
44LATS20.93073200
45PAK40.92756658
46MAP3K70.92471414
47MAP3K140.91381472
48DMPK0.90022486
49RET0.89883531
50PAK20.88848428
51CDK90.88524104
52STK40.85647623
53TTK0.85264288
54PDGFRB0.84850046
55TAOK10.83605979
56STK30.82003879
57CLK10.79711954
58HCK0.77559662
59HIPK20.77341764
60CDC42BPA0.76808463
61MST1R0.76712393
62CDK20.76672305
63DYRK1B0.76499243
64MAP3K80.76237443
65PDPK10.76217229
66PIM10.75570983
67ATM0.75335467
68BTK0.74619532
69MAP3K60.74380655
70PRKD20.74044406
71CSK0.74003661
72ITK0.72798830
73MKNK10.72630789
74CHUK0.70125033
75MARK20.69397028
76MAP3K10.69372978
77FGFR10.63317114
78JAK30.63286352
79CSF1R0.62011147
80EPHB10.61294674
81MAP2K20.61294196
82ZAP700.60762888
83DDR20.60634753
84MELK0.59703824
85SRPK10.58275413
86TGFBR20.56432318
87MAP2K30.56250853
88TSSK60.55538699
89AKT20.54999028
90AURKB0.53671195
91PRKDC0.53130225
92TGFBR10.53116169
93MAPK140.53058881
94RPS6KC10.52305859
95RPS6KL10.52305859
96NTRK10.52275531
97CSNK1D0.51900462
98CDK10.51417699
99TYK20.50393758
100PDK10.50236177
101JAK10.49878907
102BLK0.49822641
103RPS6KA40.49821443
104RPS6KA10.48234763
105SIK30.47993542
106FGR0.46211849
107YES10.46129404
108LCK0.46129277
109FGFR20.46060748
110PTK20.45768589
111RPS6KA60.45540198
112RPS6KA20.45316067
113TNK20.45196138
114MAPK100.44937757
115WNK10.44812640
116SGK30.44474751
117MAPK10.44436766
118CHEK20.44157403
119CSNK1E0.43823219
120PRKD30.43432663
121PRKCH0.43304423
122GSK3B0.43056999
123MAPK110.42881221
124MAP3K30.41866738
125TAOK20.39680001
126EPHA20.39107720
127AKT30.38909358
128IRAK40.38676298
129TRPM70.37845728
130TBK10.36461787
131MAP3K20.34586153

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005112.36695773
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.25615060
3Lysine degradation_Homo sapiens_hsa003102.15515556
4Chronic myeloid leukemia_Homo sapiens_hsa052202.02682673
5Notch signaling pathway_Homo sapiens_hsa043301.95665906
6* mRNA surveillance pathway_Homo sapiens_hsa030151.93169515
7* Spliceosome_Homo sapiens_hsa030401.81318599
8Primary immunodeficiency_Homo sapiens_hsa053401.79086993
9B cell receptor signaling pathway_Homo sapiens_hsa046621.75056122
10mTOR signaling pathway_Homo sapiens_hsa041501.62851297
11MicroRNAs in cancer_Homo sapiens_hsa052061.58052346
12Small cell lung cancer_Homo sapiens_hsa052221.50807772
13Acute myeloid leukemia_Homo sapiens_hsa052211.49537986
14Non-small cell lung cancer_Homo sapiens_hsa052231.42220809
15Basal cell carcinoma_Homo sapiens_hsa052171.39074787
16Mismatch repair_Homo sapiens_hsa034301.38545963
17T cell receptor signaling pathway_Homo sapiens_hsa046601.36980666
18HTLV-I infection_Homo sapiens_hsa051661.35519066
19* RNA transport_Homo sapiens_hsa030131.35419978
20DNA replication_Homo sapiens_hsa030301.35008940
21Adherens junction_Homo sapiens_hsa045201.34273912
22Transcriptional misregulation in cancer_Homo sapiens_hsa052021.33881268
23Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.32657380
24Cell cycle_Homo sapiens_hsa041101.31219827
25Endometrial cancer_Homo sapiens_hsa052131.28891246
26Thyroid hormone signaling pathway_Homo sapiens_hsa049191.26365961
27Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.25926950
28Colorectal cancer_Homo sapiens_hsa052101.25801984
29Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.24784301
30Proteoglycans in cancer_Homo sapiens_hsa052051.24156226
31Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.23786654
32Antigen processing and presentation_Homo sapiens_hsa046121.22156220
33Pancreatic cancer_Homo sapiens_hsa052121.19107027
34Viral carcinogenesis_Homo sapiens_hsa052031.16906864
35Base excision repair_Homo sapiens_hsa034101.16424071
36Viral myocarditis_Homo sapiens_hsa054161.15864666
37Herpes simplex infection_Homo sapiens_hsa051681.15646627
38NF-kappa B signaling pathway_Homo sapiens_hsa040641.13872571
39Dorso-ventral axis formation_Homo sapiens_hsa043201.11081016
40Osteoclast differentiation_Homo sapiens_hsa043801.10309098
41Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.10061459
42Neurotrophin signaling pathway_Homo sapiens_hsa047221.09317708
43AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.08598140
44Prion diseases_Homo sapiens_hsa050201.07711160
45One carbon pool by folate_Homo sapiens_hsa006701.04984662
46Hippo signaling pathway_Homo sapiens_hsa043901.04637061
47Leukocyte transendothelial migration_Homo sapiens_hsa046701.03806059
48Central carbon metabolism in cancer_Homo sapiens_hsa052301.03434232
49Inositol phosphate metabolism_Homo sapiens_hsa005621.02868688
50Prostate cancer_Homo sapiens_hsa052151.02160416
51Bladder cancer_Homo sapiens_hsa052191.00282011
52Glioma_Homo sapiens_hsa052140.99878320
53VEGF signaling pathway_Homo sapiens_hsa043700.99854352
54Hepatitis C_Homo sapiens_hsa051600.99601009
55Focal adhesion_Homo sapiens_hsa045100.99396917
56Measles_Homo sapiens_hsa051620.98417812
57Hepatitis B_Homo sapiens_hsa051610.98416339
58GnRH signaling pathway_Homo sapiens_hsa049120.96794748
59Toxoplasmosis_Homo sapiens_hsa051450.95824046
60Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.95462848
61Insulin resistance_Homo sapiens_hsa049310.94176401
62Toll-like receptor signaling pathway_Homo sapiens_hsa046200.91778342
63Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.91457660
64Apoptosis_Homo sapiens_hsa042100.90185945
65Pathways in cancer_Homo sapiens_hsa052000.88558527
66Longevity regulating pathway - mammal_Homo sapiens_hsa042110.86886999
67Hedgehog signaling pathway_Homo sapiens_hsa043400.86879047
68Type II diabetes mellitus_Homo sapiens_hsa049300.86695008
69Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.86553445
70Adipocytokine signaling pathway_Homo sapiens_hsa049200.84318737
71Platelet activation_Homo sapiens_hsa046110.84231630
72Leishmaniasis_Homo sapiens_hsa051400.82909267
73Non-homologous end-joining_Homo sapiens_hsa034500.82802529
74Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.82395038
75Estrogen signaling pathway_Homo sapiens_hsa049150.81855185
76Renal cell carcinoma_Homo sapiens_hsa052110.81721557
77Wnt signaling pathway_Homo sapiens_hsa043100.81550334
78Prolactin signaling pathway_Homo sapiens_hsa049170.81390835
79Thyroid cancer_Homo sapiens_hsa052160.81340862
80p53 signaling pathway_Homo sapiens_hsa041150.81262033
81Regulation of actin cytoskeleton_Homo sapiens_hsa048100.80522286
82Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.80469409
83Carbohydrate digestion and absorption_Homo sapiens_hsa049730.79452659
84Fanconi anemia pathway_Homo sapiens_hsa034600.77707575
85Jak-STAT signaling pathway_Homo sapiens_hsa046300.77676935
86FoxO signaling pathway_Homo sapiens_hsa040680.77254855
87Epstein-Barr virus infection_Homo sapiens_hsa051690.77045734
88Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.75936511
89HIF-1 signaling pathway_Homo sapiens_hsa040660.75728322
90Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.75723824
91Influenza A_Homo sapiens_hsa051640.74712662
92Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.74112006
93Insulin signaling pathway_Homo sapiens_hsa049100.73837779
94Phosphatidylinositol signaling system_Homo sapiens_hsa040700.73654912
95Chemokine signaling pathway_Homo sapiens_hsa040620.73547327
96TGF-beta signaling pathway_Homo sapiens_hsa043500.72191489
97Glycosaminoglycan degradation_Homo sapiens_hsa005310.71827967
98Hematopoietic cell lineage_Homo sapiens_hsa046400.70563746
99AMPK signaling pathway_Homo sapiens_hsa041520.66698850
100Rap1 signaling pathway_Homo sapiens_hsa040150.66026394
101Sphingolipid signaling pathway_Homo sapiens_hsa040710.65601962
102ErbB signaling pathway_Homo sapiens_hsa040120.65505156
103Complement and coagulation cascades_Homo sapiens_hsa046100.65153864
104MAPK signaling pathway_Homo sapiens_hsa040100.64996731
105ECM-receptor interaction_Homo sapiens_hsa045120.64820795
106Fructose and mannose metabolism_Homo sapiens_hsa000510.64436568
107Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.63591768
108Endocytosis_Homo sapiens_hsa041440.63511965
109Long-term potentiation_Homo sapiens_hsa047200.62557879
110RNA degradation_Homo sapiens_hsa030180.60582686
111RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.60349507
112Shigellosis_Homo sapiens_hsa051310.59847934
113Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.59052180
114TNF signaling pathway_Homo sapiens_hsa046680.58200437
115Choline metabolism in cancer_Homo sapiens_hsa052310.57940564
116Glucagon signaling pathway_Homo sapiens_hsa049220.56843733
117Amoebiasis_Homo sapiens_hsa051460.56597333
118Tight junction_Homo sapiens_hsa045300.56500717
119Phospholipase D signaling pathway_Homo sapiens_hsa040720.56318085
120Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.53924565
121Pentose phosphate pathway_Homo sapiens_hsa000300.53794790
122Staphylococcus aureus infection_Homo sapiens_hsa051500.52524937
123Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.52429827
124Tuberculosis_Homo sapiens_hsa051520.52244879
125Thyroid hormone synthesis_Homo sapiens_hsa049180.48606813

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