ACKR3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the G-protein coupled receptor family. Although this protein was earlier thought to be a receptor for vasoactive intestinal peptide (VIP), it is now considered to be an orphan receptor, in that its endogenous ligand has not been identified. The protein is also a coreceptor for human immunodeficiency viruses (HIV). Translocations involving this gene and HMGA2 on chromosome 12 have been observed in lipomas. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1peptidyl-tyrosine autophosphorylation (GO:0038083)5.38708216
2exocrine pancreas development (GO:0031017)5.23378794
3lymph vessel development (GO:0001945)4.76610201
4collagen fibril organization (GO:0030199)4.22717864
5heart trabecula formation (GO:0060347)4.07772970
6negative regulation of protein localization to cell surface (GO:2000009)4.05174145
7coronary vasculature morphogenesis (GO:0060977)4.05042159
8cardiac myofibril assembly (GO:0055003)4.01002293
9keratan sulfate catabolic process (GO:0042340)3.88509069
10heart valve formation (GO:0003188)3.85036432
11endocardial cushion morphogenesis (GO:0003203)3.78960470
12negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.78303471
13cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.71914172
14sarcomere organization (GO:0045214)3.71491925
15positive regulation of glycolytic process (GO:0045821)3.71481423
16positive regulation of respiratory burst (GO:0060267)3.64919906
17positive regulation of glycogen biosynthetic process (GO:0045725)3.58185095
18lung lobe morphogenesis (GO:0060463)3.56589917
19endothelial cell morphogenesis (GO:0001886)3.56045596
20vascular endothelial growth factor signaling pathway (GO:0038084)3.53202823
21negative regulation of smooth muscle cell differentiation (GO:0051151)3.51784038
22L-serine transport (GO:0015825)3.49349084
23myofibril assembly (GO:0030239)3.45166447
24Notch signaling involved in heart development (GO:0061314)3.43947971
25notochord development (GO:0030903)3.40933586
26protein heterotrimerization (GO:0070208)3.37549773
27plasma membrane repair (GO:0001778)3.37208014
28trabecula formation (GO:0060343)3.36628420
29calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.34618814
30cartilage condensation (GO:0001502)3.33264336
31cell aggregation (GO:0098743)3.33264336
32positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.32174494
33chondrocyte development (GO:0002063)3.31234945
34regulation of skeletal muscle contraction (GO:0014819)3.29390017
35cardiac muscle cell development (GO:0055013)3.28907393
36ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.27224425
37cardiac cell development (GO:0055006)3.26511216
38retina vasculature morphogenesis in camera-type eye (GO:0061299)3.26330549
39atrioventricular valve morphogenesis (GO:0003181)3.25934047
40glomerular basement membrane development (GO:0032836)3.22999594
41mesenchymal cell development (GO:0014031)3.21872878
42type B pancreatic cell proliferation (GO:0044342)3.20390979
43heart valve morphogenesis (GO:0003179)3.19541837
44negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.18658175
45mesenchyme morphogenesis (GO:0072132)3.16517629
46positive regulation of glycogen metabolic process (GO:0070875)3.15534733
47endothelial tube morphogenesis (GO:0061154)3.13718967
48morphogenesis of an endothelium (GO:0003159)3.13718967
49negative regulation of striated muscle cell apoptotic process (GO:0010664)3.13089879
50regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.11489608
51ventricular cardiac muscle cell development (GO:0055015)3.11253597
52cardiac muscle tissue morphogenesis (GO:0055008)3.10785024
53serine transport (GO:0032329)3.08709651
54negative regulation of chondrocyte differentiation (GO:0032331)3.08657181
55lung vasculature development (GO:0060426)3.06752777
56positive regulation of mitochondrial fission (GO:0090141)3.05937155
57atrial septum morphogenesis (GO:0060413)3.02956197
58positive regulation of cartilage development (GO:0061036)3.02746532
59muscle tissue morphogenesis (GO:0060415)3.01790756
60cardiac epithelial to mesenchymal transition (GO:0060317)2.99628501
61muscle filament sliding (GO:0030049)2.99317644
62actin-myosin filament sliding (GO:0033275)2.99317644
63prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.98809237
64cardiac right ventricle morphogenesis (GO:0003215)2.96829900
65ear development (GO:0043583)2.96285514
66Notch receptor processing (GO:0007220)2.95728232
67limb bud formation (GO:0060174)2.94855065
68ventricular trabecula myocardium morphogenesis (GO:0003222)2.93753815
69cell proliferation involved in kidney development (GO:0072111)2.93416498
70neural crest cell development (GO:0014032)2.92643424
71lymphangiogenesis (GO:0001946)2.91033574
72glomerular filtration (GO:0003094)2.90194576
73Golgi transport vesicle coating (GO:0048200)2.89267752
74COPI coating of Golgi vesicle (GO:0048205)2.89267752
75actin-mediated cell contraction (GO:0070252)2.88417268
76growth hormone secretion (GO:0030252)2.88322314
77renal filtration (GO:0097205)2.87754632
78positive regulation of osteoblast proliferation (GO:0033690)2.86836115
79regulation of actin filament-based movement (GO:1903115)2.86582365
80positive regulation of chondrocyte differentiation (GO:0032332)2.86076634
81cardiac muscle cell proliferation (GO:0060038)2.84878702
82modulation by virus of host morphology or physiology (GO:0019048)2.84453183
83cell proliferation involved in metanephros development (GO:0072203)2.82412980
84skin morphogenesis (GO:0043589)2.82188700
85collagen metabolic process (GO:0032963)2.81720617
86positive regulation of endothelial cell apoptotic process (GO:2000353)2.81200040
87regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.79493507
88regulation of protein localization to cell surface (GO:2000008)2.76316886
89regulation of cardiac muscle cell apoptotic process (GO:0010665)2.75792322
90negative regulation of cartilage development (GO:0061037)2.75356490
91regulation of striated muscle cell apoptotic process (GO:0010662)2.75338574
92regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.74671592
93negative regulation of potassium ion transmembrane transport (GO:1901380)2.74050057
94cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.73922617
95hemidesmosome assembly (GO:0031581)2.73808784
96gap junction assembly (GO:0016264)2.73229591
97vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.73098982
98short-term memory (GO:0007614)2.72956186
99regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.70554540
100collagen catabolic process (GO:0030574)2.70057550
101regulation of vasculogenesis (GO:2001212)2.69452848
102striated muscle hypertrophy (GO:0014897)2.68544042
103positive regulation of heart rate (GO:0010460)2.68024305
104actomyosin structure organization (GO:0031032)2.67508686
105protein heterotetramerization (GO:0051290)2.67040173
106multicellular organismal macromolecule metabolic process (GO:0044259)2.66851701
107male sex determination (GO:0030238)2.66818197
108positive regulation of extracellular matrix organization (GO:1903055)2.66741838
109glycine transport (GO:0015816)2.66281758
110chondrocyte proliferation (GO:0035988)2.64855448
111aorta morphogenesis (GO:0035909)2.64057675
112stem cell development (GO:0048864)2.62172875
113regulation of heart morphogenesis (GO:2000826)2.61957331
114regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.61620848
115glomerulus development (GO:0032835)2.59028674
116cardiac muscle hypertrophy (GO:0003300)2.58576269
117cell surface receptor signaling pathway involved in heart development (GO:0061311)2.58542878
118cAMP biosynthetic process (GO:0006171)2.57980884
119cell migration involved in sprouting angiogenesis (GO:0002042)2.57938980
120extracellular matrix assembly (GO:0085029)2.57891972
121regulation of cardioblast differentiation (GO:0051890)2.56219917
122activation of protein kinase B activity (GO:0032148)2.55437003
123ventricular septum morphogenesis (GO:0060412)2.55238885
124trabecula morphogenesis (GO:0061383)2.55152432
125endothelium development (GO:0003158)2.54468139
126axon extension involved in axon guidance (GO:0048846)2.54421917
127neuron projection extension involved in neuron projection guidance (GO:1902284)2.54421917
128multicellular organismal metabolic process (GO:0044236)2.53563758
129surfactant homeostasis (GO:0043129)2.52729959
130multicellular organismal catabolic process (GO:0044243)2.50427222
131basement membrane organization (GO:0071711)2.50331833
132regulation of smooth muscle cell differentiation (GO:0051150)2.49530937
133positive regulation of heart contraction (GO:0045823)2.49105942
134negative regulation of fatty acid transport (GO:2000192)2.48492091
135negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.47999283
136regulation of chondrocyte differentiation (GO:0032330)2.47899390
137regulation of cartilage development (GO:0061035)2.47316637
138cardiac ventricle morphogenesis (GO:0003208)2.46953622
139blood vessel maturation (GO:0001955)2.45528705
140cardiac muscle contraction (GO:0060048)2.45064498
141extracellular fibril organization (GO:0043206)2.43437916
142positive regulation of keratinocyte differentiation (GO:0045618)2.43434261
143positive regulation of glucose import (GO:0046326)2.41747456
144response to BMP (GO:0071772)2.40471167
145cellular response to BMP stimulus (GO:0071773)2.40471167
146vasculature development (GO:0001944)2.39824807
147mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.39189846
148positive regulation of vascular permeability (GO:0043117)2.38070210
149positive regulation of urine volume (GO:0035810)2.35574871
150establishment of planar polarity (GO:0001736)2.35275959
151establishment of tissue polarity (GO:0007164)2.35275959
152cardiac chamber morphogenesis (GO:0003206)2.34431831
153pyrimidine nucleobase catabolic process (GO:0006208)2.33074523
154gamma-aminobutyric acid transport (GO:0015812)2.31725984
155mesonephros development (GO:0001823)2.29438552
156maternal placenta development (GO:0001893)2.29287527
157heart trabecula morphogenesis (GO:0061384)2.27989867
158fibroblast migration (GO:0010761)2.26299206
159regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.25999233
160regulation of cell proliferation involved in kidney development (GO:1901722)2.24692432
161amyloid precursor protein catabolic process (GO:0042987)2.24424502
162regulation of mitochondrial fission (GO:0090140)2.24359045
163lens fiber cell development (GO:0070307)2.23595575
164negative regulation of blood vessel endothelial cell migration (GO:0043537)2.22323232
165ephrin receptor signaling pathway (GO:0048013)2.22170620
166bundle of His cell to Purkinje myocyte communication (GO:0086069)2.22099360
167branching involved in salivary gland morphogenesis (GO:0060445)2.21694186
168negative regulation of endothelial cell migration (GO:0010596)2.20693090
169peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.20182092
170regulation of endothelial cell chemotaxis (GO:2001026)2.20061099
171insulin-like growth factor receptor signaling pathway (GO:0048009)2.19864345

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human5.33242743
2RBPJ_22232070_ChIP-Seq_NCS_Mouse4.61870814
3TP63_17297297_ChIP-ChIP_HaCaT_Human3.74524847
4RARG_19884340_ChIP-ChIP_MEFs_Mouse3.33933979
5TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.73993358
6CLOCK_20551151_ChIP-Seq_293T_Human2.68369913
7EP300_21415370_ChIP-Seq_HL-1_Mouse2.62443671
8ESR1_21235772_ChIP-Seq_MCF-7_Human2.40762100
9ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.34687836
10ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.31990174
11AR_21572438_ChIP-Seq_LNCaP_Human2.14164471
12CJUN_26792858_Chip-Seq_BT549_Human2.13505392
13PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.13151021
14EED_16625203_ChIP-ChIP_MESCs_Mouse2.06637681
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.03155354
16TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.00574917
17ESR2_21235772_ChIP-Seq_MCF-7_Human1.99396142
18PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.99367082
19CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.99029140
20CDX2_19796622_ChIP-Seq_MESCs_Mouse1.94371434
21WT1_19549856_ChIP-ChIP_CCG9911_Human1.91345364
22SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.90216585
23SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.85985157
24EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.85135531
25RNF2_18974828_ChIP-Seq_MESCs_Mouse1.81988982
26EZH2_18974828_ChIP-Seq_MESCs_Mouse1.81988982
27CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.81608134
28TBX20_22328084_ChIP-Seq_HEART_Mouse1.80602955
29TBX20_22080862_ChIP-Seq_HEART_Mouse1.80602955
30CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.78934439
31SMAD_19615063_ChIP-ChIP_OVARY_Human1.78508017
32ZNF217_24962896_ChIP-Seq_MCF-7_Human1.76628936
33ESR1_20079471_ChIP-ChIP_T-47D_Human1.74725450
34HIF1A_21447827_ChIP-Seq_MCF-7_Human1.73831393
35SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.68229557
36SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.63933548
37STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.62934850
38EZH2_27304074_Chip-Seq_ESCs_Mouse1.62014371
39SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.60729822
40ESR1_15608294_ChIP-ChIP_MCF-7_Human1.57713682
41NRF2_20460467_ChIP-Seq_MEFs_Mouse1.53452890
42NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.53452890
43KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.51771834
44KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.51771834
45KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.51771834
46RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.51470482
47PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.48890154
48TP53_18474530_ChIP-ChIP_U2OS_Human1.48462960
49PPAR_26484153_Chip-Seq_NCI-H1993_Human1.46992615
50E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.46928610
51CBX2_27304074_Chip-Seq_ESCs_Mouse1.45511525
52THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.44389429
53JARID2_20075857_ChIP-Seq_MESCs_Mouse1.42852785
54WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.40620556
55SOX9_24532713_ChIP-Seq_HFSC_Mouse1.39450245
56ERG_21242973_ChIP-ChIP_JURKAT_Human1.38007261
57GATA2_21666600_ChIP-Seq_HMVEC_Human1.36166701
58MTF2_20144788_ChIP-Seq_MESCs_Mouse1.35839088
59TP53_20018659_ChIP-ChIP_R1E_Mouse1.35007890
60CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.35006792
61TP53_16413492_ChIP-PET_HCT116_Human1.34561251
62TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.33350346
63JARID2_20064375_ChIP-Seq_MESCs_Mouse1.32627192
64RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.30705709
65CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.30380030
66FOXO3_23340844_ChIP-Seq_DLD1_Human1.29957116
67AHR_22903824_ChIP-Seq_MCF-7_Human1.29845100
68TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.27734526
69TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.25694502
70RNF2_27304074_Chip-Seq_ESCs_Mouse1.22153182
71SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.21913760
72SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.21913760
73RUNX1_27514584_Chip-Seq_MCF-7_Human1.19933703
74PIAS1_25552417_ChIP-Seq_VCAP_Human1.19927285
75BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.19700206
76SOX2_20726797_ChIP-Seq_SW620_Human1.18191179
77RACK7_27058665_Chip-Seq_MCF-7_Human1.17333130
78ISL1_27105846_Chip-Seq_CPCs_Mouse1.17284181
79EZH2_22144423_ChIP-Seq_EOC_Human1.16517632
80EZH2_27294783_Chip-Seq_ESCs_Mouse1.15669206
81SALL4_18804426_ChIP-ChIP_XEN_Mouse1.14872784
82BRD4_25478319_ChIP-Seq_HGPS_Human1.14152455
83FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.13648039
84TCF4_18268006_ChIP-ChIP_LS174T_Human1.13314169
85MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.12286553
86NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.10574864
87JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.10104012
88GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.08946716
89PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.08197033
90JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.07362234
91RING1B_27294783_Chip-Seq_ESCs_Mouse1.07222952
92SUZ12_27294783_Chip-Seq_ESCs_Mouse1.06856229
93CDX2_20551321_ChIP-Seq_CACO-2_Human1.04862378
94P63_26484246_Chip-Seq_KERATINOCYTES_Human1.04514923
95SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.04202925
96TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.04148441
97ARNT_22903824_ChIP-Seq_MCF-7_Human1.03889064
98ELK3_25401928_ChIP-Seq_HUVEC_Human1.02653916
99NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.00137989
100DNAJC2_21179169_ChIP-ChIP_NT2_Human0.99569246
101BCAT_22108803_ChIP-Seq_LS180_Human0.99536243
102ZFP281_18757296_ChIP-ChIP_E14_Mouse0.99480152
103ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.99351192
104NFIB_24661679_ChIP-Seq_LUNG_Mouse0.98861298
105HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.98731757
106CTCF_27219007_Chip-Seq_Bcells_Human0.98279568
107SMC1_22415368_ChIP-Seq_MEFs_Mouse0.97624956
108SMAD3_21741376_ChIP-Seq_HESCs_Human0.96602786
109ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.96531521
110STAT6_21828071_ChIP-Seq_BEAS2B_Human0.94351330
111RXR_22108803_ChIP-Seq_LS180_Human0.93517427
112OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.93468102
113* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.93166900
114TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93023452
115SA1_22415368_ChIP-Seq_MEFs_Mouse0.92695091
116RING1B_27294783_Chip-Seq_NPCs_Mouse0.92042924
117NR3C1_23031785_ChIP-Seq_PC12_Mouse0.91185577
118SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.90870641
119NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.90783199
120DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.90145517
121TP63_23658742_ChIP-Seq_EP156T_Human0.89363564
122KDM2B_26808549_Chip-Seq_K562_Human0.88788165
123SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.87708617
124GATA3_24758297_ChIP-Seq_MCF-7_Human0.87688817
125TP53_22127205_ChIP-Seq_IMR90_Human0.87174226
126DROSHA_22980978_ChIP-Seq_HELA_Human0.87103515
127FOXM1_26456572_ChIP-Seq_MCF-7_Human0.86472822
128ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.85740875
129ZNF263_19887448_ChIP-Seq_K562_Human0.85504339
130SMAD4_21741376_ChIP-Seq_HESCs_Human0.85256883
131SMC3_22415368_ChIP-Seq_MEFs_Mouse0.84752031
132UBF1/2_26484160_Chip-Seq_HMECs_Human0.84444935
133TET1_21490601_ChIP-Seq_MESCs_Mouse0.84205973
134PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.81440561
135NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.79835128
136CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.79813682
137SMC4_20622854_ChIP-Seq_HELA_Human0.79756516

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.17658949
2MP0005503_abnormal_tendon_morphology4.03807860
3MP0009384_cardiac_valve_regurgitation3.32969243
4MP0005275_abnormal_skin_tensile3.32593329
5MP0002837_dystrophic_cardiac_calcinosis3.22413991
6MP0000751_myopathy3.19737998
7MP0003279_aneurysm3.04598621
8MP0004272_abnormal_basement_membrane2.95355951
9MP0004084_abnormal_cardiac_muscle2.80341862
10MP0010368_abnormal_lymphatic_system2.78814408
11MP0003646_muscle_fatigue2.70147655
12MP0001958_emphysema2.65050973
13MP0003705_abnormal_hypodermis_morpholog2.48234169
14MP0003011_delayed_dark_adaptation2.46318236
15MP0001879_abnormal_lymphatic_vessel2.36718768
16MP0005084_abnormal_gallbladder_morpholo2.33939306
17MP0004215_abnormal_myocardial_fiber2.24803854
18MP0005330_cardiomyopathy2.22784555
19MP0002282_abnormal_trachea_morphology2.12246124
20MP0009250_abnormal_appendicular_skeleto2.07741208
21MP0000749_muscle_degeneration2.07674653
22MP0006138_congestive_heart_failure2.04526728
23MP0002822_catalepsy2.02449315
24MP0002108_abnormal_muscle_morphology2.02285843
25MP0004484_altered_response_of2.01323182
26MP0003828_pulmonary_edema1.83334569
27MP0002972_abnormal_cardiac_muscle1.82455456
28MP0004036_abnormal_muscle_relaxation1.81790732
29MP0000750_abnormal_muscle_regeneration1.81626119
30MP0005623_abnormal_meninges_morphology1.73854908
31MP0002249_abnormal_larynx_morphology1.73527749
32MP0003950_abnormal_plasma_membrane1.70605512
33MP0000163_abnormal_cartilage_morphology1.66847610
34MP0002796_impaired_skin_barrier1.66783457
35MP0005508_abnormal_skeleton_morphology1.66275445
36MP0005499_abnormal_olfactory_system1.65522293
37MP0005394_taste/olfaction_phenotype1.65522293
38MP0003941_abnormal_skin_development1.65517502
39MP0005620_abnormal_muscle_contractility1.63521202
40MP0004087_abnormal_muscle_fiber1.60368205
41MP0004133_heterotaxia1.58445473
42MP0009780_abnormal_chondrocyte_physiolo1.57443769
43MP0001544_abnormal_cardiovascular_syste1.55016439
44MP0005385_cardiovascular_system_phenoty1.55016439
45MP0000383_abnormal_hair_follicle1.54427734
46MP0010030_abnormal_orbit_morphology1.52914139
47MP0000049_abnormal_middle_ear1.50376656
48MP0008789_abnormal_olfactory_epithelium1.49728434
49MP0002933_joint_inflammation1.49457585
50MP0010630_abnormal_cardiac_muscle1.48145725
51MP0002896_abnormal_bone_mineralization1.47069330
52MP0000767_abnormal_smooth_muscle1.46922067
53MP0004858_abnormal_nervous_system1.45038183
54MP0000762_abnormal_tongue_morphology1.44102004
55MP0003566_abnormal_cell_adhesion1.43088726
56MP0000462_abnormal_digestive_system1.42928963
57MP0002295_abnormal_pulmonary_circulatio1.40819230
58MP0000566_synostosis1.40318402
59MP0002127_abnormal_cardiovascular_syste1.40031943
60MP0008775_abnormal_heart_ventricle1.39709503
61MP0000579_abnormal_nail_morphology1.38919125
62MP0002653_abnormal_ependyma_morphology1.37243738
63MP0000003_abnormal_adipose_tissue1.36979008
64MP0003136_yellow_coat_color1.34688315
65MP0002009_preneoplasia1.32684275
66MP0004085_abnormal_heartbeat1.31838050
67MP0005167_abnormal_blood-brain_barrier1.26946282
68MP0002877_abnormal_melanocyte_morpholog1.25454792
69MP0005369_muscle_phenotype1.24361854
70MP0002234_abnormal_pharynx_morphology1.24265812
71MP0006054_spinal_hemorrhage1.23272440
72MP0003385_abnormal_body_wall1.21725904
73MP0002060_abnormal_skin_morphology1.21389370
74MP0002115_abnormal_skeleton_extremities1.21301402
75MP0000537_abnormal_urethra_morphology1.20415218
76MP0004134_abnormal_chest_morphology1.20149073
77MP0000343_altered_response_to1.17128518
78MP0000759_abnormal_skeletal_muscle1.15294469
79MP0003137_abnormal_impulse_conducting1.14745120
80MP0002106_abnormal_muscle_physiology1.12260609
81MP0004233_abnormal_muscle_weight1.11053459
82MP0005501_abnormal_skin_physiology1.10637457
83MP0002098_abnormal_vibrissa_morphology1.10526311
84MP0005365_abnormal_bile_salt1.10421023
85MP0000733_abnormal_muscle_development1.09239186
86MP0001270_distended_abdomen1.08539661
87MP0005165_increased_susceptibility_to1.06196237
88MP0008260_abnormal_autophagy1.04897774
89MP0001542_abnormal_bone_strength1.04649068
90MP0005670_abnormal_white_adipose1.03559210
91MP0002113_abnormal_skeleton_development1.03499348
92MP0005023_abnormal_wound_healing1.03188605
93MP0005390_skeleton_phenotype1.02342513
94MP0004264_abnormal_extraembryonic_tissu1.01922441
95MP0005666_abnormal_adipose_tissue1.00916422
96MP0010678_abnormal_skin_adnexa0.99584627
97MP0002638_abnormal_pupillary_reflex0.99181898
98MP0008995_early_reproductive_senescence0.98592770
99MP0005409_darkened_coat_color0.98502850
100MP0002128_abnormal_blood_circulation0.98084676
101MP0004782_abnormal_surfactant_physiolog0.97562076
102MP0000613_abnormal_salivary_gland0.94317129
103MP0003724_increased_susceptibility_to0.93002948
104MP0001299_abnormal_eye_distance/0.92674568
105MP0005595_abnormal_vascular_smooth0.90297989
106MP0003935_abnormal_craniofacial_develop0.90000977
107MP0003938_abnormal_ear_development0.89672879
108MP0002332_abnormal_exercise_endurance0.89327877
109MP0003119_abnormal_digestive_system0.86528145
110MP0005257_abnormal_intraocular_pressure0.86201265
111MP0003091_abnormal_cell_migration0.85745812
112MP0004130_abnormal_muscle_cell0.85467668
113MP0002925_abnormal_cardiovascular_devel0.84130298
114MP0003755_abnormal_palate_morphology0.84067513
115MP0000026_abnormal_inner_ear0.83547973
116MP0002233_abnormal_nose_morphology0.83460197
117MP0000266_abnormal_heart_morphology0.83207643
118MP0000516_abnormal_urinary_system0.83149308
119MP0005367_renal/urinary_system_phenotyp0.83149308
120MP0002133_abnormal_respiratory_system0.82805712
121MP0005388_respiratory_system_phenotype0.82805712
122MP0000465_gastrointestinal_hemorrhage0.82181984
123MP0001849_ear_inflammation0.81703004
124MP0002932_abnormal_joint_morphology0.81506254
125MP0001529_abnormal_vocalization0.80743651
126MP0000678_abnormal_parathyroid_gland0.80600511
127MP0000467_abnormal_esophagus_morphology0.79680174
128MP0002116_abnormal_craniofacial_bone0.79569268
129MP0005164_abnormal_response_to0.79308752
130MP0000534_abnormal_ureter_morphology0.79156430
131MP0005375_adipose_tissue_phenotype0.78859249
132MP0000230_abnormal_systemic_arterial0.78689589
133MP0004185_abnormal_adipocyte_glucose0.76863272
134MP0001614_abnormal_blood_vessel0.76610824
135MP0002751_abnormal_autonomic_nervous0.76478105
136MP0003942_abnormal_urinary_system0.76448252
137MP0002269_muscular_atrophy0.76013067
138MP0000013_abnormal_adipose_tissue0.75977000
139MP0002109_abnormal_limb_morphology0.75865316
140MP0003115_abnormal_respiratory_system0.75338557
141MP0005197_abnormal_uvea_morphology0.74722970
142MP0009672_abnormal_birth_weight0.73859520
143MP0010771_integument_phenotype0.73139977
144MP0005171_absent_coat_pigmentation0.73034105
145MP0000538_abnormal_urinary_bladder0.72843936
146MP0003191_abnormal_cellular_cholesterol0.72033660
147MP0004885_abnormal_endolymph0.66558475

Predicted human phenotypes

RankGene SetZ-score
1Thick nail (HP:0001805)5.00716316
2Epiphyseal dysplasia (HP:0002656)4.66782130
3Enlarged penis (HP:0000040)4.42415623
4Long foot (HP:0001833)4.23150376
5Neonatal short-limb short stature (HP:0008921)4.22899275
6Growth hormone excess (HP:0000845)4.22636141
7Hypoplastic ischia (HP:0003175)4.18990162
8Protrusio acetabuli (HP:0003179)4.12251343
9Premature rupture of membranes (HP:0001788)4.02610458
10Aplasia/Hypoplasia of the pubic bone (HP:0009104)4.02016492
11Elfin facies (HP:0004428)3.91462186
12Muscle fiber splitting (HP:0003555)3.88377226
13Increased connective tissue (HP:0009025)3.66335881
14Abnormality of the ischium (HP:0003174)3.64187807
15Hypoglycemic seizures (HP:0002173)3.46040862
16Abnormality of the calf musculature (HP:0001430)3.40030514
17Irregular epiphyses (HP:0010582)3.29749491
18Vitreoretinal degeneration (HP:0000655)3.28786476
19Aortic aneurysm (HP:0004942)3.28163525
20Reduced subcutaneous adipose tissue (HP:0003758)3.27993676
21Cupped ribs (HP:0000887)3.27343668
22Sudden death (HP:0001699)3.20324788
23Lymphangioma (HP:0100764)3.19323543
24Calf muscle hypertrophy (HP:0008981)3.14490798
25Ventricular tachycardia (HP:0004756)3.11840523
26Right ventricular cardiomyopathy (HP:0011663)3.06715664
27Metaphyseal cupping (HP:0003021)3.04846877
28Hyperinsulinemic hypoglycemia (HP:0000825)3.01232720
29Alopecia of scalp (HP:0002293)3.00411609
30Aortic dissection (HP:0002647)2.97525462
31Advanced eruption of teeth (HP:0006288)2.96044570
32Mild short stature (HP:0003502)2.92746716
33Spinal rigidity (HP:0003306)2.91313484
34Pulmonary artery stenosis (HP:0004415)2.91166324
35Atrial fibrillation (HP:0005110)2.89671547
36Exercise-induced muscle cramps (HP:0003710)2.86648924
37Broad metatarsal (HP:0001783)2.84165236
38Congenital, generalized hypertrichosis (HP:0004540)2.79987233
39Hypoglycemic coma (HP:0001325)2.79821623
40Lipoatrophy (HP:0100578)2.74467524
41Abnormal tarsal ossification (HP:0008369)2.74104770
42Pancreatic islet-cell hyperplasia (HP:0004510)2.73977177
43Delayed CNS myelination (HP:0002188)2.73350960
44Muscle hypertrophy of the lower extremities (HP:0008968)2.68843770
45Primary atrial arrhythmia (HP:0001692)2.67210707
46Acanthosis nigricans (HP:0000956)2.65927979
47Limited hip movement (HP:0008800)2.63967160
48Distal lower limb muscle weakness (HP:0009053)2.62907683
49Flat acetabular roof (HP:0003180)2.59627153
50Metaphyseal dysplasia (HP:0100255)2.58376450
51Coxa vara (HP:0002812)2.55323936
52Supraventricular arrhythmia (HP:0005115)2.54848850
53Supraventricular tachycardia (HP:0004755)2.53259358
54Hip contracture (HP:0003273)2.51992047
55Osteoarthritis (HP:0002758)2.51003956
56Small epiphyses (HP:0010585)2.50903396
57Ankle contracture (HP:0006466)2.50789031
58Vascular tortuosity (HP:0004948)2.47220305
59Hyporeflexia of lower limbs (HP:0002600)2.47045531
60Type 1 muscle fiber predominance (HP:0003803)2.46464958
61Ulnar claw (HP:0001178)2.45903106
62Long toe (HP:0010511)2.45724392
63Short hallux (HP:0010109)2.45631932
64Flat capital femoral epiphysis (HP:0003370)2.44712808
65Cervical subluxation (HP:0003308)2.44565393
66Soft skin (HP:0000977)2.44294037
67Arterial tortuosity (HP:0005116)2.42936431
68Genu varum (HP:0002970)2.41636937
69Shallow orbits (HP:0000586)2.40920253
70Absent eyelashes (HP:0000561)2.40625398
71Atrophic scars (HP:0001075)2.39912678
72Split foot (HP:0001839)2.39568891
73Insulin-resistant diabetes mellitus (HP:0000831)2.38437315
74Wormian bones (HP:0002645)2.32811228
75Abnormal vertebral ossification (HP:0100569)2.30440422
76Abnormality of the pubic bones (HP:0003172)2.27733987
77Renal dysplasia (HP:0000110)2.26882232
78Platyspondyly (HP:0000926)2.23062668
79Aplasia/Hypoplasia of the hallux (HP:0008362)2.22009730
80Mildly elevated creatine phosphokinase (HP:0008180)2.21479530
81Bicornuate uterus (HP:0000813)2.20752680
82Abnormality of nail color (HP:0100643)2.19033160
83Delayed epiphyseal ossification (HP:0002663)2.18852472
84Overgrowth (HP:0001548)2.16860928
85Arthropathy (HP:0003040)2.15913728
86Follicular hyperkeratosis (HP:0007502)2.15797632
87Limb-girdle muscle atrophy (HP:0003797)2.15072857
88Symptomatic seizures (HP:0011145)2.13185902
89Abnormal foot bone ossification (HP:0010675)2.12901039
90Increased variability in muscle fiber diameter (HP:0003557)2.12674814
91Subaortic stenosis (HP:0001682)2.12415417
92Abnormality of the left ventricular outflow tract (HP:0011103)2.12415417
93Abnormality of the vertebral endplates (HP:0005106)2.10744166
94Exercise-induced myalgia (HP:0003738)2.09739716
95Fibular aplasia (HP:0002990)2.08134098
96Mesomelia (HP:0003027)2.07907970
97EMG: myopathic abnormalities (HP:0003458)2.06646272
98Prolonged QT interval (HP:0001657)2.03067773
99Adactyly (HP:0009776)2.02970208
100Abnormality of dentin (HP:0010299)2.01341861
101Abnormality involving the epiphyses of the lower limbs (HP:0006500)2.00533088
102Abnormality of femoral epiphyses (HP:0006499)2.00533088
103Aortic regurgitation (HP:0001659)2.00175548
104Absent hand (HP:0004050)1.98990609
105Cerebral aneurysm (HP:0004944)1.97765832
106Dilated cardiomyopathy (HP:0001644)1.96714438
107Abnormality of the middle phalanges of the toes (HP:0010183)1.95811525
108Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.95504844
109Abnormality of the acetabulum (HP:0003170)1.95139474
110Hydroureter (HP:0000072)1.94941910
111Wide anterior fontanel (HP:0000260)1.94715454
112Bladder diverticulum (HP:0000015)1.94607432
113Fibular hypoplasia (HP:0003038)1.94523997
114Bronchomalacia (HP:0002780)1.94139109
115Abnormality of the phalanges of the 2nd finger (HP:0009541)1.93813354
116Wrist flexion contracture (HP:0001239)1.93060334
117Occipital encephalocele (HP:0002085)1.91518621
118Abnormality of carpal bone ossification (HP:0006257)1.91416061
119Waddling gait (HP:0002515)1.91165952
120Concave nail (HP:0001598)1.91022872
121Back pain (HP:0003418)1.91021612
122Irregular vertebral endplates (HP:0003301)1.90781893
123Difficulty climbing stairs (HP:0003551)1.89209792
124Hyperpituitarism (HP:0010514)1.89193597
125Abnormality of skeletal muscle fiber size (HP:0012084)1.87486501
126Ovoid vertebral bodies (HP:0003300)1.86429030
127Fragile skin (HP:0001030)1.86276591
128Thin ribs (HP:0000883)1.85649884
129Broad ribs (HP:0000885)1.84689536
130Exostoses (HP:0100777)1.83810901
131Lumbar hyperlordosis (HP:0002938)1.83453365
132Down-sloping shoulders (HP:0200021)1.82523478
133Abnormality of the proximal phalanges of the hand (HP:0009834)1.82488185
134Microglossia (HP:0000171)1.80224007
135Myotonia (HP:0002486)1.77732784
136Flattened epiphyses (HP:0003071)1.76615720
137Vertebral compression fractures (HP:0002953)1.76442640
138Visceral angiomatosis (HP:0100761)1.75567712
139Ketoacidosis (HP:0001993)1.75546797
140Neoplasm of the heart (HP:0100544)1.75077412
141Hypotrichosis (HP:0001006)1.73389725
142Abnormality of the pulmonary veins (HP:0011718)1.72268233
143Morphological abnormality of the middle ear (HP:0008609)1.71104008
144Infantile muscular hypotonia (HP:0008947)1.70474682
145Coronal craniosynostosis (HP:0004440)1.70049250
146Camptodactyly of toe (HP:0001836)1.69510510
147Spastic diplegia (HP:0001264)1.67414499
148Hyperventilation (HP:0002883)1.64143634
149Esophageal varix (HP:0002040)1.62874843
150Keratoconus (HP:0000563)1.61966863
151Increased corneal curvature (HP:0100692)1.61966863
152Choanal stenosis (HP:0000452)1.61001383
153Accelerated skeletal maturation (HP:0005616)1.60622156
154Thickened nuchal skin fold (HP:0000474)1.60242382
155Intellectual disability, moderate (HP:0002342)1.57867251
156Vaginal atresia (HP:0000148)1.57157356
157Abdominal distention (HP:0003270)1.54819654
158Ectropion (HP:0000656)1.54595270
159Hypodontia (HP:0000668)1.54231806
160Epidermoid cyst (HP:0200040)1.53890970
161Striae distensae (HP:0001065)1.53851386
162Abnormality of the anterior chamber (HP:0000593)1.51834053
163Unilateral renal agenesis (HP:0000122)1.50837100
164Intestinal atresia (HP:0011100)1.50643027
165Genital tract atresia (HP:0001827)1.49215940
166Absent speech (HP:0001344)1.49109309
167Hemangiomatosis (HP:0007461)1.48417116
168Joint laxity (HP:0001388)1.48028730
169Precocious puberty (HP:0000826)1.46114384
170Septo-optic dysplasia (HP:0100842)1.46030195
171Osteopenia (HP:0000938)1.45867411
172Asymmetry of the thorax (HP:0001555)1.45224953
173Heterochromia iridis (HP:0001100)1.44595860

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MYLK4.04620192
2TTN3.99818443
3STK38L3.58374979
4MAP3K33.16945546
5DDR23.13301355
6CASK3.02140467
7DMPK2.94867173
8EPHB22.57902074
9TIE12.52545754
10STK242.33799252
11MAP2K72.15903802
12LATS12.13771629
13PDK22.09579674
14PHKG21.97893907
15PHKG11.97893907
16TESK11.96246463
17MAP3K41.90047428
18TRIB31.89138662
19TGFBR21.85220857
20PDGFRA1.82559207
21INSRR1.79262153
22MAP4K21.77285300
23PAK31.68837521
24LMTK21.63246064
25EPHA21.59784933
26FER1.56153398
27TRPM71.51870189
28PIK3CA1.46444099
29MAPK151.43662715
30MST41.42601104
31ROCK11.40600322
32OBSCN1.37072592
33PAK21.36248482
34ZAK1.33092587
35EPHA31.32019739
36RIPK11.30537012
37PIM21.28579033
38PDK31.23532390
39PDK41.23532390
40WNK41.22108154
41PRKD11.21942953
42LATS21.20700248
43BCKDK1.20340934
44PTK2B1.13679086
45EPHB11.12295984
46MAP2K21.11293957
47DYRK1B1.10504129
48NUAK11.09083233
49BCR1.07974793
50TRIM281.07191434
51ERBB31.06374527
52MARK11.03505852
53LIMK10.99624315
54SIK30.98706133
55GSK3A0.97397363
56KDR0.96345705
57STK30.94145222
58SIK10.92705828
59ARAF0.92469572
60PKN20.92373311
61MAP2K10.87403983
62MET0.87391037
63RPS6KA20.84986096
64MAP2K40.83350811
65CDC42BPA0.83116087
66AKT30.82754776
67ERN10.81420430
68ROCK20.80080116
69PRKCE0.78492919
70PTK60.78192164
71ILK0.78177738
72MAPK120.77978004
73ERBB40.75338382
74PDGFRB0.75110240
75NLK0.74876260
76PTK20.73772757
77CAMK2G0.73039886
78GRK50.68289142
79PRKG20.67827160
80MST1R0.67581202
81MAP2K30.67127341
82PINK10.66364311
83MAPKAPK30.66337068
84MAP3K20.66061771
85NME10.65509151
86CSNK1A1L0.64931398
87CAMK2B0.62253224
88PRKAA20.62132326
89MAP3K60.61787748
90MUSK0.61352672
91GRK70.61204584
92TAOK10.61002123
93STK390.59524140
94MAPK70.59181104
95TESK20.58869093
96TAOK20.57996739
97PRPF4B0.56650670
98CDK90.56528289
99MAPK130.56263668
100CSNK1G30.56072568
101MAP3K70.55198354
102PRKD30.54817507
103TGFBR10.54786620
104RPS6KB20.53430079
105PRKD20.52300927
106CAMK1D0.50854097
107NEK90.48821969
108PLK20.47727755
109MARK20.46501576
110RET0.46324341
111PAK40.46310204
112CAMK2D0.46130191
113ICK0.45747803
114WNK30.45295600
115WNK10.44206776
116BMX0.43729605
117NEK60.43658426
118FRK0.43404331
119GRK10.42617960
120VRK20.40408852
121PRKCH0.40142124
122MKNK20.39484925
123STK380.38453099
124DAPK30.37855790
125FGFR10.37517962
126DYRK30.37415555
127MOS0.37401495
128CSNK1G20.36950971
129NTRK20.36806215
130RPS6KA40.36295719
131EPHA40.34834020
132MTOR0.34773411
133PRKCZ0.33745195
134SCYL20.33471390
135CHUK0.31914237
136NTRK10.31876811
137LRRK20.31765994
138GRK60.31148519
139CSNK1G10.31132128
140RPS6KL10.29652569
141RPS6KC10.29652569
142INSR0.29488929
143MAPK90.27472855
144CAMK40.27313534
145IGF1R0.27246852
146DYRK20.22540286
147EEF2K0.22342542
148ADRBK10.22308428
149CDK50.22180833
150AKT20.22111138

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045124.03244547
2Dilated cardiomyopathy_Homo sapiens_hsa054143.45053162
3Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.35646983
4Taurine and hypotaurine metabolism_Homo sapiens_hsa004303.13448075
5Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.92496382
6Focal adhesion_Homo sapiens_hsa045102.70028416
7Protein digestion and absorption_Homo sapiens_hsa049742.49598434
8Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.30449370
9Glycosaminoglycan degradation_Homo sapiens_hsa005312.15244782
10Cardiac muscle contraction_Homo sapiens_hsa042602.09840353
11Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.00805351
12Adherens junction_Homo sapiens_hsa045201.79542979
13TGF-beta signaling pathway_Homo sapiens_hsa043501.73836043
14Propanoate metabolism_Homo sapiens_hsa006401.59499044
15Starch and sucrose metabolism_Homo sapiens_hsa005001.56566999
16Proteoglycans in cancer_Homo sapiens_hsa052051.51802438
17Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.51740692
18Vibrio cholerae infection_Homo sapiens_hsa051101.49233175
19Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.46178859
20AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.45555576
21Fructose and mannose metabolism_Homo sapiens_hsa000511.44448899
22Steroid biosynthesis_Homo sapiens_hsa001001.43059095
23Viral myocarditis_Homo sapiens_hsa054161.41749465
24Amoebiasis_Homo sapiens_hsa051461.36645866
25Phenylalanine metabolism_Homo sapiens_hsa003601.34900675
26Basal cell carcinoma_Homo sapiens_hsa052171.33949556
27PI3K-Akt signaling pathway_Homo sapiens_hsa041511.31551862
282-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.28876997
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.25702520
30Hippo signaling pathway_Homo sapiens_hsa043901.25531481
31cGMP-PKG signaling pathway_Homo sapiens_hsa040221.24771755
32Pentose and glucuronate interconversions_Homo sapiens_hsa000401.24444422
33beta-Alanine metabolism_Homo sapiens_hsa004101.22395981
34Prion diseases_Homo sapiens_hsa050201.21751868
35Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.19343039
36Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.17583526
37Fatty acid degradation_Homo sapiens_hsa000711.14285027
38Small cell lung cancer_Homo sapiens_hsa052221.14064008
39Malaria_Homo sapiens_hsa051441.14002411
40Vascular smooth muscle contraction_Homo sapiens_hsa042701.09785846
41Hedgehog signaling pathway_Homo sapiens_hsa043401.08900624
42Tight junction_Homo sapiens_hsa045301.06987902
43Sulfur relay system_Homo sapiens_hsa041221.04622405
44Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.03005808
45Insulin resistance_Homo sapiens_hsa049311.01918118
46Notch signaling pathway_Homo sapiens_hsa043300.99246135
47Biosynthesis of amino acids_Homo sapiens_hsa012300.98169896
48Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.96139169
49Sulfur metabolism_Homo sapiens_hsa009200.95184028
50Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.93600514
51Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.93010583
52Ovarian steroidogenesis_Homo sapiens_hsa049130.92874341
53Fatty acid metabolism_Homo sapiens_hsa012120.92392560
54Axon guidance_Homo sapiens_hsa043600.91281772
55Renin secretion_Homo sapiens_hsa049240.91214250
56PPAR signaling pathway_Homo sapiens_hsa033200.90875255
57Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.89519480
58Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.89398200
59Leukocyte transendothelial migration_Homo sapiens_hsa046700.88880687
60Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.87591897
61Regulation of actin cytoskeleton_Homo sapiens_hsa048100.87205862
62Primary bile acid biosynthesis_Homo sapiens_hsa001200.85370005
63Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.85192388
64Rap1 signaling pathway_Homo sapiens_hsa040150.85010881
65GABAergic synapse_Homo sapiens_hsa047270.84551939
66HIF-1 signaling pathway_Homo sapiens_hsa040660.83582795
67Oxidative phosphorylation_Homo sapiens_hsa001900.83015557
68Circadian rhythm_Homo sapiens_hsa047100.82880838
69Pathways in cancer_Homo sapiens_hsa052000.81451471
70Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.81439346
71Parkinsons disease_Homo sapiens_hsa050120.81429087
72Butanoate metabolism_Homo sapiens_hsa006500.80343983
73ABC transporters_Homo sapiens_hsa020100.78246023
74Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.76913867
75Adipocytokine signaling pathway_Homo sapiens_hsa049200.76730805
76Central carbon metabolism in cancer_Homo sapiens_hsa052300.75172542
77Wnt signaling pathway_Homo sapiens_hsa043100.74984979
78MicroRNAs in cancer_Homo sapiens_hsa052060.74962480
79Arginine and proline metabolism_Homo sapiens_hsa003300.74440610
80Cocaine addiction_Homo sapiens_hsa050300.74030537
81Melanoma_Homo sapiens_hsa052180.73508870
82cAMP signaling pathway_Homo sapiens_hsa040240.73210635
83Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.72274854
84Histidine metabolism_Homo sapiens_hsa003400.71136533
85Alzheimers disease_Homo sapiens_hsa050100.71034135
86Oxytocin signaling pathway_Homo sapiens_hsa049210.70325611
87alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.68564223
88Thyroid hormone signaling pathway_Homo sapiens_hsa049190.68555442
89Sphingolipid metabolism_Homo sapiens_hsa006000.67192164
90Gap junction_Homo sapiens_hsa045400.66771122
91Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.66557149
92Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.66412237
93Phospholipase D signaling pathway_Homo sapiens_hsa040720.65200470
94Galactose metabolism_Homo sapiens_hsa000520.64812446
95Prostate cancer_Homo sapiens_hsa052150.63440538
96Renal cell carcinoma_Homo sapiens_hsa052110.63192137
97Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.63046424
98Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.62990811
99Melanogenesis_Homo sapiens_hsa049160.62593385
100Endometrial cancer_Homo sapiens_hsa052130.62475465
101Bile secretion_Homo sapiens_hsa049760.62083519
102Pentose phosphate pathway_Homo sapiens_hsa000300.60989543
103Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.60438038
104mTOR signaling pathway_Homo sapiens_hsa041500.59934691
105Chemical carcinogenesis_Homo sapiens_hsa052040.59931154
106Arachidonic acid metabolism_Homo sapiens_hsa005900.58071710
107Fatty acid elongation_Homo sapiens_hsa000620.57765699
108Glucagon signaling pathway_Homo sapiens_hsa049220.57513331
109Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.57419561
110Platelet activation_Homo sapiens_hsa046110.57294295
111Tyrosine metabolism_Homo sapiens_hsa003500.57005546
112Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.55295525
113Carbon metabolism_Homo sapiens_hsa012000.54750272
114Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.54588175
115Lysine degradation_Homo sapiens_hsa003100.54539758
116Calcium signaling pathway_Homo sapiens_hsa040200.53550128
117Huntingtons disease_Homo sapiens_hsa050160.53530270
118Morphine addiction_Homo sapiens_hsa050320.53166063
119Ras signaling pathway_Homo sapiens_hsa040140.53059287
120AMPK signaling pathway_Homo sapiens_hsa041520.52813541
121Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.51984940
122Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.51806078
123Bladder cancer_Homo sapiens_hsa052190.51648602
124Toxoplasmosis_Homo sapiens_hsa051450.51298402
125Collecting duct acid secretion_Homo sapiens_hsa049660.51196096
126Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.50050667
127Gastric acid secretion_Homo sapiens_hsa049710.49856629
128Tryptophan metabolism_Homo sapiens_hsa003800.49750026
129Insulin signaling pathway_Homo sapiens_hsa049100.49735949
130Cyanoamino acid metabolism_Homo sapiens_hsa004600.49084794
131Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.47802782
132Estrogen signaling pathway_Homo sapiens_hsa049150.47558189
133Pyruvate metabolism_Homo sapiens_hsa006200.47475501
134Dorso-ventral axis formation_Homo sapiens_hsa043200.47347715
135Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.47247029
136Mineral absorption_Homo sapiens_hsa049780.47083659
137Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.46925509
138Choline metabolism in cancer_Homo sapiens_hsa052310.46186409
139Glutathione metabolism_Homo sapiens_hsa004800.46161674
140Peroxisome_Homo sapiens_hsa041460.45104447
141Thyroid hormone synthesis_Homo sapiens_hsa049180.45011077
142MAPK signaling pathway_Homo sapiens_hsa040100.44967335
143Linoleic acid metabolism_Homo sapiens_hsa005910.44404608
144Retinol metabolism_Homo sapiens_hsa008300.43563235
145Longevity regulating pathway - mammal_Homo sapiens_hsa042110.41375200

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