ACLY

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Multiple transcript variants encoding distinct isoforms have been identified for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)9.96909848
2Golgi transport vesicle coating (GO:0048200)9.96909848
3retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)6.26366158
4COPII vesicle coating (GO:0048208)6.02061668
5endocrine pancreas development (GO:0031018)5.98391161
6protein maturation by protein folding (GO:0022417)5.71626373
7nuclear pore complex assembly (GO:0051292)5.53367946
8maintenance of protein localization in endoplasmic reticulum (GO:0035437)5.49218021
9activation of signaling protein activity involved in unfolded protein response (GO:0006987)5.39218146
10positive regulation of nuclease activity (GO:0032075)5.14239421
11nuclear pore organization (GO:0006999)5.00124222
12vesicle coating (GO:0006901)4.82540809
13protein retention in ER lumen (GO:0006621)4.77417197
14regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022354.72655061
15peptide hormone processing (GO:0016486)4.72653274
16regulation of nuclease activity (GO:0032069)4.65822882
17endoplasmic reticulum unfolded protein response (GO:0030968)4.58600242
18DNA unwinding involved in DNA replication (GO:0006268)4.56872699
19cellular response to unfolded protein (GO:0034620)4.43323759
20ER-nucleus signaling pathway (GO:0006984)4.36101682
21macroautophagy (GO:0016236)4.35111996
22exocrine pancreas development (GO:0031017)4.28999072
23cellular response to topologically incorrect protein (GO:0035967)4.28994398
24regulation of translational fidelity (GO:0006450)4.27154854
25type B pancreatic cell development (GO:0003323)4.26806198
26glandular epithelial cell differentiation (GO:0002067)4.25209096
27regulation of type B pancreatic cell apoptotic process (GO:2000674)4.09044154
28low-density lipoprotein particle clearance (GO:0034383)3.99325829
29glandular epithelial cell development (GO:0002068)3.98968681
30pore complex assembly (GO:0046931)3.94746270
31insulin secretion (GO:0030073)3.93518458
32ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)3.87015708
33mitotic chromosome condensation (GO:0007076)3.81522486
34positive regulation of insulin secretion (GO:0032024)3.79544781
35establishment of integrated proviral latency (GO:0075713)3.76621298
36L-alpha-amino acid transmembrane transport (GO:1902475)3.72151785
37sequestering of metal ion (GO:0051238)3.69195826
38alpha-linolenic acid metabolic process (GO:0036109)3.68479722
39protein complex localization (GO:0031503)3.67291484
40response to endoplasmic reticulum stress (GO:0034976)3.64194270
41positive regulation of glycolytic process (GO:0045821)3.63045763
424-hydroxyproline metabolic process (GO:0019471)3.60789868
43paraxial mesoderm development (GO:0048339)3.60446815
44proline biosynthetic process (GO:0006561)3.51015484
45ER overload response (GO:0006983)3.48988244
46regulation of insulin secretion (GO:0050796)3.46734669
47cellular protein complex localization (GO:0034629)3.44514725
48nitric oxide mediated signal transduction (GO:0007263)3.44168719
49fatty acid homeostasis (GO:0055089)3.41718299
50regulation of cholesterol homeostasis (GO:2000188)3.35991652
51toxin metabolic process (GO:0009404)3.35451480
52heterochromatin organization (GO:0070828)3.32995765
53response to unfolded protein (GO:0006986)3.30814454
54peptidyl-asparagine modification (GO:0018196)3.27932629
55Golgi organization (GO:0007030)3.27261212
56positive regulation of histone deacetylation (GO:0031065)3.27242895
57intra-Golgi vesicle-mediated transport (GO:0006891)3.27009558
58protein N-linked glycosylation via asparagine (GO:0018279)3.26880122
59protein localization to chromosome, centromeric region (GO:0071459)3.25191334
60* long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.25149457
61ER to Golgi vesicle-mediated transport (GO:0006888)3.24205866
62response to topologically incorrect protein (GO:0035966)3.23079214
63erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.22679468
64L-phenylalanine catabolic process (GO:0006559)3.22679468
65signal peptide processing (GO:0006465)3.22049403
66mitotic sister chromatid cohesion (GO:0007064)3.20910201
67* fatty-acyl-CoA biosynthetic process (GO:0046949)3.20588425
68mitotic sister chromatid segregation (GO:0000070)3.18921343
69regulation of Golgi to plasma membrane protein transport (GO:0042996)3.17376979
70protein localization to kinetochore (GO:0034501)3.17211563
71regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.16831720
72negative regulation of insulin secretion (GO:0046676)3.16563542
73response to lipoprotein particle (GO:0055094)3.15011600
74regulation of peptide hormone secretion (GO:0090276)3.14732418
75mitotic nuclear envelope disassembly (GO:0007077)3.13553704
76regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.12271758
77DNA strand elongation involved in DNA replication (GO:0006271)3.11955290
78folic acid-containing compound biosynthetic process (GO:0009396)3.11333532
79positive regulation of peptide hormone secretion (GO:0090277)3.11040916
80columnar/cuboidal epithelial cell development (GO:0002066)3.08948025
81regulation of peptide secretion (GO:0002791)3.08857825
82sister chromatid segregation (GO:0000819)3.08669236
83negative regulation of glycoprotein biosynthetic process (GO:0010561)3.05508398
84DNA strand elongation (GO:0022616)3.03165073
85astrocyte differentiation (GO:0048708)3.03003938
86response to hexose (GO:0009746)3.01871296
87positive regulation of peptide secretion (GO:0002793)3.01239610
88epithelial cell fate commitment (GO:0072148)2.99908357
89response to glucose (GO:0009749)2.99513383
90membrane disassembly (GO:0030397)2.99236003
91nuclear envelope disassembly (GO:0051081)2.99236003
92protein N-linked glycosylation (GO:0006487)2.99221115
93L-serine metabolic process (GO:0006563)2.98403213
94intestinal cholesterol absorption (GO:0030299)2.97506264
95cerebellar Purkinje cell layer development (GO:0021680)2.97382530
96hemidesmosome assembly (GO:0031581)2.96761829
97erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.94894411
98L-phenylalanine metabolic process (GO:0006558)2.94894411
99NADPH regeneration (GO:0006740)2.94831214
100* thioester biosynthetic process (GO:0035384)2.94097224
101* acyl-CoA biosynthetic process (GO:0071616)2.94097224
102response to monosaccharide (GO:0034284)2.90843314
103intestinal absorption (GO:0050892)2.90166279
104DNA duplex unwinding (GO:0032508)2.89263775
105regulation of glucose import in response to insulin stimulus (GO:2001273)2.89150804
106response to dietary excess (GO:0002021)2.88526547
107ribosome assembly (GO:0042255)2.87003117
108peptide hormone secretion (GO:0030072)2.85762419
109peptide secretion (GO:0002790)2.85183851
110regulation of RNA export from nucleus (GO:0046831)2.84729944
111pre-miRNA processing (GO:0031054)2.83280755
112mitotic metaphase plate congression (GO:0007080)2.82448531
113protein autoprocessing (GO:0016540)2.81934007
114cellular response to vitamin D (GO:0071305)2.81490886
115DNA replication initiation (GO:0006270)2.80182913
116spliceosomal tri-snRNP complex assembly (GO:0000244)2.79883934
117negative regulation of peptide hormone secretion (GO:0090278)2.79426010
118acylglycerol catabolic process (GO:0046464)2.78647640
119neutral lipid catabolic process (GO:0046461)2.78647640
120cellular response to glucagon stimulus (GO:0071377)2.78535131
121protein export from nucleus (GO:0006611)2.76762617
122valine metabolic process (GO:0006573)2.76638860
123biotin metabolic process (GO:0006768)2.76407671
124pentose-phosphate shunt (GO:0006098)2.76332715
125cholesterol biosynthetic process (GO:0006695)2.75110012
126regulation of cholesterol biosynthetic process (GO:0045540)2.73728452
127negative regulation of bone resorption (GO:0045779)2.73616571
128cellular zinc ion homeostasis (GO:0006882)2.73531370
129DNA geometric change (GO:0032392)2.73466113
130planar cell polarity pathway involved in neural tube closure (GO:0090179)2.72245943
131endoplasmic reticulum organization (GO:0007029)2.72229251
132triglyceride catabolic process (GO:0019433)2.71423983
133regulation of translational termination (GO:0006449)2.71406380
134positive regulation of hormone biosynthetic process (GO:0046886)2.71241600
135establishment of apical/basal cell polarity (GO:0035089)2.69625173
136acetyl-CoA metabolic process (GO:0006084)2.69134202
137ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.68823253
138negative regulation of peptide secretion (GO:0002792)2.67628866
139regulation of hormone secretion (GO:0046883)2.67609569
140carbohydrate homeostasis (GO:0033500)2.67324624
141establishment of viral latency (GO:0019043)2.66539570
142positive regulation of chromosome segregation (GO:0051984)2.66391104
143IMP biosynthetic process (GO:0006188)2.63131398
144formation of translation preinitiation complex (GO:0001731)2.60678661
145chromosome condensation (GO:0030261)2.59540669
146protein localization to microtubule (GO:0035372)2.59277929
147negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.59219137
148glucose 6-phosphate metabolic process (GO:0051156)2.57899236
149nucleobase-containing small molecule interconversion (GO:0015949)2.57741871
150desmosome organization (GO:0002934)2.57717145
151peptidyl-arginine omega-N-methylation (GO:0035247)2.57561346
152glucose catabolic process (GO:0006007)2.57527225
153adherens junction assembly (GO:0034333)2.57081086
154double-strand break repair via nonhomologous end joining (GO:0006303)2.56483847
155non-recombinational repair (GO:0000726)2.56483847
156regulation of translational elongation (GO:0006448)2.55608597
157regulation of mammary gland epithelial cell proliferation (GO:0033599)2.54382765
158hippo signaling (GO:0035329)2.53241410
159nuclear envelope organization (GO:0006998)2.52300754
160regulation of mitotic spindle organization (GO:0060236)2.52287401
161tRNA aminoacylation for protein translation (GO:0006418)2.49435859
162regulation of sister chromatid cohesion (GO:0007063)2.49214204
163regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.48738914
164regulation of nucleobase-containing compound transport (GO:0032239)2.45667719
165cell-substrate junction assembly (GO:0007044)2.43918425
166glutamine metabolic process (GO:0006541)2.41877355
167nucleosome disassembly (GO:0006337)2.41537635
168protein-DNA complex disassembly (GO:0032986)2.41537635
169convergent extension (GO:0060026)2.40806583
170DNA conformation change (GO:0071103)2.40769854
171tRNA aminoacylation (GO:0043039)2.38620911
172amino acid activation (GO:0043038)2.38620911
173epithelial cell-cell adhesion (GO:0090136)2.38190876
174cellular response to epidermal growth factor stimulus (GO:0071364)2.38117404
175histone arginine methylation (GO:0034969)2.36697037
176cell adhesion mediated by integrin (GO:0033627)2.36185619
177tetrahydrofolate metabolic process (GO:0046653)2.35754685
178cytoskeletal anchoring at plasma membrane (GO:0007016)2.34163825
179IMP metabolic process (GO:0046040)2.33327770
180telomere maintenance via semi-conservative replication (GO:0032201)2.33238283
181NLS-bearing protein import into nucleus (GO:0006607)2.32823010
182metaphase plate congression (GO:0051310)2.32697496
183cell-substrate adherens junction assembly (GO:0007045)2.31871099
184focal adhesion assembly (GO:0048041)2.31871099
185sterol biosynthetic process (GO:0016126)2.30734249

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse8.28520377
2E2F7_22180533_ChIP-Seq_HELA_Human8.02432663
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.21425365
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.94462805
5* ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.75178247
6RXR_22158963_ChIP-Seq_LIVER_Mouse3.59332933
7* MYC_18555785_ChIP-Seq_MESCs_Mouse3.32416796
8STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.31710247
9GATA1_22025678_ChIP-Seq_K562_Human3.31247458
10* CLOCK_20551151_ChIP-Seq_293T_Human3.30085891
11AR_21909140_ChIP-Seq_LNCAP_Human3.24413103
12* LXR_22158963_ChIP-Seq_LIVER_Mouse3.06464188
13* PPARA_22158963_ChIP-Seq_LIVER_Mouse3.00774467
14* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.94292356
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.72502741
16FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.63515030
17MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.55825156
18TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.48792126
19E2F4_17652178_ChIP-ChIP_JURKAT_Human2.46639569
20* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.43193332
21PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.36948046
22* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.36933970
23FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.30321510
24* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.26241684
25NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.19236099
26* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.17411512
27* DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.16010682
28* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat2.12317790
29MYCN_18555785_ChIP-Seq_MESCs_Mouse2.08198712
30NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.02566739
31SOX2_27498859_Chip-Seq_STOMACH_Mouse2.02261665
32POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.00617723
33MYC_18358816_ChIP-ChIP_MESCs_Mouse2.00031961
34ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.96878710
35PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.93029864
36POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.83708960
37ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.83071833
38E2F1_21310950_ChIP-Seq_MCF-7_Human1.82154711
39FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.81976513
40ZNF263_19887448_ChIP-Seq_K562_Human1.79827516
41TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.79163296
42XRN2_22483619_ChIP-Seq_HELA_Human1.76644884
43SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.73334913
44* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.69439057
45* NANOG_18555785_ChIP-Seq_MESCs_Mouse1.64905523
46* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.63434863
47CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.62289814
48NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.59678623
49ESR1_15608294_ChIP-ChIP_MCF-7_Human1.59052273
50TFEB_21752829_ChIP-Seq_HELA_Human1.58912839
51* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.57077439
52TP63_17297297_ChIP-ChIP_HaCaT_Human1.53466944
53STAT6_21828071_ChIP-Seq_BEAS2B_Human1.53447371
54* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.52853486
55TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.52549872
56MYC_22102868_ChIP-Seq_BL_Human1.52532145
57CREB1_15753290_ChIP-ChIP_HEK293T_Human1.47261065
58YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.46212544
59GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.45246727
60SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.44177431
61OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.43755554
62DCP1A_22483619_ChIP-Seq_HELA_Human1.43077417
63EGR1_19374776_ChIP-ChIP_THP-1_Human1.42866759
64MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.42404209
65TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.40866250
66CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.40449707
67PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.39403540
68* FOXA2_19822575_ChIP-Seq_HepG2_Human1.38534659
69NFIB_24661679_ChIP-Seq_LUNG_Mouse1.38219589
70ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.37998114
71GATA1_19941826_ChIP-Seq_K562_Human1.37529254
72P300_27058665_Chip-Seq_ZR-75-30cells_Human1.36463434
73FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.35279243
74AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.33596018
75LXR_22292898_ChIP-Seq_THP-1_Human1.31963475
76TTF2_22483619_ChIP-Seq_HELA_Human1.30674540
77SOX17_20123909_ChIP-Seq_XEN_Mouse1.30501943
78* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.28073310
79NR3C1_23031785_ChIP-Seq_PC12_Mouse1.27864782
80ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.27675926
81CREB1_26743006_Chip-Seq_LNCaP_Human1.27174683
82* CHD1_26751641_Chip-Seq_LNCaP_Human1.26757591
83KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.26365054
84KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.25917486
85SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.25542053
86KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.25379805
87ESR1_21235772_ChIP-Seq_MCF-7_Human1.24423510
88STAT3_1855785_ChIP-Seq_MESCs_Mouse1.22443103
89RBPJ_22232070_ChIP-Seq_NCS_Mouse1.22118459
90KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.21572814
91TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.21218732
92WT1_19549856_ChIP-ChIP_CCG9911_Human1.20582403
93CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.19783405
94SOX2_18555785_ChIP-Seq_MESCs_Mouse1.19543006
95BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.19144356
96HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.18586841
97PKCTHETA_26484144_Chip-Seq_BREAST_Human1.18572089
98* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.18557239
99ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.18498575
100KDM2B_26808549_Chip-Seq_K562_Human1.17279034
101ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.15990234
102FOXA1_25552417_ChIP-Seq_VCAP_Human1.15195003
103KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.14782223
104FOXO3_23340844_ChIP-Seq_DLD1_Human1.14661630
105RACK7_27058665_Chip-Seq_MCF-7_Human1.14217740
106CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.13477539
107NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.11754162
108TCF3_18692474_ChIP-Seq_MEFs_Mouse1.09822329
109EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.09405173
110JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.08878880
111KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.08842446
112CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.08478445
113KDM5A_27292631_Chip-Seq_BREAST_Human1.08442552
114FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.07981312
115GABP_19822575_ChIP-Seq_HepG2_Human1.07683785
116RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.07012506
117* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.06552877
118TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.05468445
119* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.05244083
120EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.04618898
121* KDM2B_26808549_Chip-Seq_DND41_Human1.04613108
122GATA6_25053715_ChIP-Seq_YYC3_Human1.04525309
123SALL1_21062744_ChIP-ChIP_HESCs_Human1.02993181
124* ELK3_25401928_ChIP-Seq_HUVEC_Human1.02797670
125ATF3_27146783_Chip-Seq_COLON_Human1.02590053
126REST_19997604_ChIP-ChIP_NEURONS_Mouse1.01983469
127TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.01003106
128GATA3_24758297_ChIP-Seq_MCF-7_Human0.99486139
129* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.99392892
130RARG_19884340_ChIP-ChIP_MEFs_Mouse0.99244529
131EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.95615060
132WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.95507342
133ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.94922257
134E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.92997976
135CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.92834417
136SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.92815570
137NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.92764050
138TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.92312808
139ETS1_20019798_ChIP-Seq_JURKAT_Human0.91134717
140ESR2_21235772_ChIP-Seq_MCF-7_Human0.90769950
141CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.90469365
142SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.89968770
143ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.88849689
144DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.88731203
145TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.88611050
146RUNX1_27514584_Chip-Seq_MCF-7_Human0.86292274
147TRIM28_21343339_ChIP-Seq_HEK293_Human0.84870897
148PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.83437746
149* SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.83395865
150TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.82837327
151TBX20_22328084_ChIP-Seq_HEART_Mouse0.81894209
152TBX20_22080862_ChIP-Seq_HEART_Mouse0.81894209
153FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.80524737
154REST_18959480_ChIP-ChIP_MESCs_Mouse0.79819809
155PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.79602349
156NANOG_21062744_ChIP-ChIP_HESCs_Human0.79387534
157KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.79347337
158GATA4_25053715_ChIP-Seq_YYC3_Human0.77649436
159E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.77598764
160NCOR1_26117541_ChIP-Seq_K562_Human0.76436705
161* HNF4A_19822575_ChIP-Seq_HepG2_Human0.76420609
162HIF1A_21447827_ChIP-Seq_MCF-7_Human0.76198931
163ZNF274_21170338_ChIP-Seq_K562_Hela0.75675540

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003283_abnormal_digestive_organ4.72757622
2MP0002877_abnormal_melanocyte_morpholog4.68445804
3MP0002909_abnormal_adrenal_gland4.04867303
4MP0009780_abnormal_chondrocyte_physiolo3.72624241
5MP0000013_abnormal_adipose_tissue3.58552874
6MP0002693_abnormal_pancreas_physiology3.42133408
7MP0001944_abnormal_pancreas_morphology3.31035634
8MP0004043_abnormal_pH_regulation3.13870633
9MP0003195_calcinosis3.10223796
10MP0002139_abnormal_hepatobiliary_system3.10144272
11MP0004272_abnormal_basement_membrane2.67767522
12MP0003941_abnormal_skin_development2.66297259
13MP0003111_abnormal_nucleus_morphology2.63902256
14MP0005220_abnormal_exocrine_pancreas2.55844842
15MP0004957_abnormal_blastocyst_morpholog2.55440783
16MP0010386_abnormal_urinary_bladder2.46385062
17MP0002078_abnormal_glucose_homeostasis2.43661377
18MP0005365_abnormal_bile_salt2.36621071
19MP0005379_endocrine/exocrine_gland_phen2.36240014
20MP0003693_abnormal_embryo_hatching2.33809734
21MP0000003_abnormal_adipose_tissue2.33025964
22MP0010094_abnormal_chromosome_stability2.30287948
23MP0000537_abnormal_urethra_morphology2.29616342
24MP0003300_gastrointestinal_ulcer2.23284086
25MP0003183_abnormal_peptide_metabolism2.19319405
26MP0005670_abnormal_white_adipose2.16296375
27MP0000678_abnormal_parathyroid_gland2.10668679
28MP0008932_abnormal_embryonic_tissue2.09154238
29MP0001730_embryonic_growth_arrest2.05338138
30MP0005623_abnormal_meninges_morphology1.96464457
31MP0003077_abnormal_cell_cycle1.92386312
32MP0008057_abnormal_DNA_replication1.89115638
33MP0002837_dystrophic_cardiac_calcinosis1.88278622
34MP0008961_abnormal_basal_metabolism1.88066919
35MP0003252_abnormal_bile_duct1.82938198
36MP0004185_abnormal_adipocyte_glucose1.81911329
37MP0005375_adipose_tissue_phenotype1.80496062
38MP0004233_abnormal_muscle_weight1.76885369
39MP0003172_abnormal_lysosome_physiology1.74083095
40MP0004264_abnormal_extraembryonic_tissu1.71184672
41MP0001672_abnormal_embryogenesis/_devel1.65477073
42MP0005380_embryogenesis_phenotype1.65477073
43MP0005083_abnormal_biliary_tract1.64408907
44MP0005666_abnormal_adipose_tissue1.62844121
45MP0002118_abnormal_lipid_homeostasis1.59289294
46MP0003868_abnormal_feces_composition1.58778055
47MP0005085_abnormal_gallbladder_physiolo1.58371650
48MP0003984_embryonic_growth_retardation1.55670010
49MP0010329_abnormal_lipoprotein_level1.53996227
50MP0008007_abnormal_cellular_replicative1.53412371
51MP0000350_abnormal_cell_proliferation1.52882252
52MP0002084_abnormal_developmental_patter1.51833527
53MP0002896_abnormal_bone_mineralization1.48999576
54MP0002088_abnormal_embryonic_growth/wei1.48554983
55MP0006072_abnormal_retinal_apoptosis1.48383758
56MP0001661_extended_life_span1.46448070
57MP0003953_abnormal_hormone_level1.46180297
58MP0005058_abnormal_lysosome_morphology1.45570917
59MP0003959_abnormal_lean_body1.45001339
60MP0009840_abnormal_foam_cell1.44854912
61MP0005076_abnormal_cell_differentiation1.44444035
62MP0002085_abnormal_embryonic_tissue1.44147622
63MP0002254_reproductive_system_inflammat1.44131458
64MP0002697_abnormal_eye_size1.43958499
65MP0000579_abnormal_nail_morphology1.41482035
66MP0000462_abnormal_digestive_system1.41398147
67MP0005645_abnormal_hypothalamus_physiol1.41186754
68MP0003705_abnormal_hypodermis_morpholog1.39499035
69* MP0002080_prenatal_lethality1.39049576
70MP0010030_abnormal_orbit_morphology1.38735896
71MP0002796_impaired_skin_barrier1.37671990
72MP0009643_abnormal_urine_homeostasis1.35466329
73MP0002060_abnormal_skin_morphology1.31645327
74MP0002928_abnormal_bile_duct1.31200305
75MP0002086_abnormal_extraembryonic_tissu1.31195799
76MP0001697_abnormal_embryo_size1.30652094
77MP0010234_abnormal_vibrissa_follicle1.30443741
78MP0001915_intracranial_hemorrhage1.29824373
79MP0010307_abnormal_tumor_latency1.28087179
80MP0000609_abnormal_liver_physiology1.27006782
81MP0004130_abnormal_muscle_cell1.26799903
82MP0005334_abnormal_fat_pad1.26353434
83MP0009672_abnormal_birth_weight1.24627147
84MP0005535_abnormal_body_temperature1.24606468
85MP0004197_abnormal_fetal_growth/weight/1.24577343
86MP0003937_abnormal_limbs/digits/tail_de1.21896698
87MP0003122_maternal_imprinting1.20413743
88MP0003942_abnormal_urinary_system1.20094340
89MP0005501_abnormal_skin_physiology1.20090792
90MP0001756_abnormal_urination1.19985379
91MP0002638_abnormal_pupillary_reflex1.18916549
92MP0000639_abnormal_adrenal_gland1.18892884
93MP0003385_abnormal_body_wall1.18300412
94MP0002970_abnormal_white_adipose1.14373053
95MP0005448_abnormal_energy_balance1.13940886
96MP0003315_abnormal_perineum_morphology1.12791263
97MP0000762_abnormal_tongue_morphology1.12532700
98MP0003119_abnormal_digestive_system1.12155108
99MP0005409_darkened_coat_color1.11609930
100MP0001666_abnormal_nutrient_absorption1.10977548
101MP0008058_abnormal_DNA_repair1.10752619
102MP0002234_abnormal_pharynx_morphology1.07068118
103MP0000428_abnormal_craniofacial_morphol1.07009975
104MP0003890_abnormal_embryonic-extraembry1.05697169
105MP0009053_abnormal_anal_canal1.05494146
106MP0002138_abnormal_hepatobiliary_system1.02717206
107MP0003329_amyloid_beta_deposits1.00384950
108MP0002971_abnormal_brown_adipose1.00184303
109MP0000534_abnormal_ureter_morphology0.99606182
110MP0003806_abnormal_nucleotide_metabolis0.99130852
111MP0003115_abnormal_respiratory_system0.98579387
112MP0003718_maternal_effect0.97983030
113MP0001986_abnormal_taste_sensitivity0.97692259
114MP0001881_abnormal_mammary_gland0.97481668
115MP0000566_synostosis0.96862477
116MP0003091_abnormal_cell_migration0.96567136
117MP0002111_abnormal_tail_morphology0.95802137
118MP0001765_abnormal_ion_homeostasis0.93451149
119MP0005187_abnormal_penis_morphology0.93081043
120MP0003045_fibrosis0.93050629
121MP0004858_abnormal_nervous_system0.92920007
122MP0002092_abnormal_eye_morphology0.92852084
123MP0003935_abnormal_craniofacial_develop0.90566253
124MP0002089_abnormal_postnatal_growth/wei0.89821435
125MP0000627_abnormal_mammary_gland0.88814435
126MP0001299_abnormal_eye_distance/0.88750137
127MP0003755_abnormal_palate_morphology0.88524690
128MP0005360_urolithiasis0.87749118
129MP0000432_abnormal_head_morphology0.86533182
130MP0005621_abnormal_cell_physiology0.85830086
131MP0009703_decreased_birth_body0.84504242
132MP0001270_distended_abdomen0.84498158
133MP0005257_abnormal_intraocular_pressure0.84051448
134MP0000467_abnormal_esophagus_morphology0.83603103
135MP0003861_abnormal_nervous_system0.83544133
136MP0004270_analgesia0.83205337
137MP0005452_abnormal_adipose_tissue0.83145714
138MP0000613_abnormal_salivary_gland0.80405104
139MP0006054_spinal_hemorrhage0.80063249
140MP0008438_abnormal_cutaneous_collagen0.79406745
141MP0009697_abnormal_copulation0.79213806
142MP0003950_abnormal_plasma_membrane0.79189169
143MP0005408_hypopigmentation0.79125084
144MP0002233_abnormal_nose_morphology0.77947097
145MP0002168_other_aberrant_phenotype0.77818067
146MP0005384_cellular_phenotype0.77806740
147MP0001216_abnormal_epidermal_layer0.76231043
148MP0005646_abnormal_pituitary_gland0.76016289
149MP0005451_abnormal_body_composition0.75550700
150MP0010352_gastrointestinal_tract_polyps0.75055388
151MP0001849_ear_inflammation0.75037686
152MP0001348_abnormal_lacrimal_gland0.74352488
153MP0002009_preneoplasia0.74232689
154MP0001286_abnormal_eye_development0.72931810
155MP0003943_abnormal_hepatobiliary_system0.71759920
156MP0005197_abnormal_uvea_morphology0.70541090
157MP0004782_abnormal_surfactant_physiolog0.70452972
158MP0000538_abnormal_urinary_bladder0.67437494
159MP0009642_abnormal_blood_homeostasis0.65432852
160MP0005332_abnormal_amino_acid0.63815835
161MP0002876_abnormal_thyroid_physiology0.63686748
162MP0005636_abnormal_mineral_homeostasis0.62631712
163MP0000631_abnormal_neuroendocrine_gland0.62254029
164MP0003566_abnormal_cell_adhesion0.61744694
165MP0005248_abnormal_Harderian_gland0.59116536
166MP0003123_paternal_imprinting0.56725017
167MP0000598_abnormal_liver_morphology0.56078374
168MP0000230_abnormal_systemic_arterial0.55178716
169MP0002069_abnormal_eating/drinking_beha0.54840646

Predicted human phenotypes

RankGene SetZ-score
1Hyperinsulinemic hypoglycemia (HP:0000825)7.13256878
2Hypoglycemic seizures (HP:0002173)6.76302388
3Hypoglycemic coma (HP:0001325)6.34969778
4Symptomatic seizures (HP:0011145)5.67529295
5Elevated circulating parathyroid hormone (PTH) level (HP:0003165)5.52955194
6Insulin-resistant diabetes mellitus (HP:0000831)4.90610195
7Abnormality of endocrine pancreas physiology (HP:0012093)4.75682447
8Abnormality of the pancreatic islet cells (HP:0006476)4.75682447
9Hyperglycemia (HP:0003074)4.68591716
10Ketoacidosis (HP:0001993)4.68384197
11Pancreatic islet-cell hyperplasia (HP:0004510)4.37523884
12Premature rupture of membranes (HP:0001788)4.02900287
13Late onset (HP:0003584)3.88394071
14Large for gestational age (HP:0001520)3.65779201
15Abnormality of aromatic amino acid family metabolism (HP:0004338)3.46612943
16Abnormality of calcium-phosphate metabolism (HP:0100530)3.44118225
17Urinary glycosaminoglycan excretion (HP:0003541)3.44089764
18Mucopolysacchariduria (HP:0008155)3.44089764
19Insulin resistance (HP:0000855)3.36237405
20Ketosis (HP:0001946)3.30240866
21Abnormal pancreas size (HP:0012094)3.26440830
22Abnormality of the intrinsic pathway (HP:0010989)3.13160358
23Abnormality of polysaccharide metabolism (HP:0011012)3.11144360
24Abnormality of glycosaminoglycan metabolism (HP:0004371)3.11144360
25Abnormality of mucopolysaccharide metabolism (HP:0011020)3.11144360
26Dysostosis multiplex (HP:0000943)2.99230483
27Asymmetry of the thorax (HP:0001555)2.97514237
28Hyperacusis (HP:0010780)2.87787159
29Protrusio acetabuli (HP:0003179)2.81027736
30Agitation (HP:0000713)2.69983085
31Macroorchidism (HP:0000053)2.67894266
32Limb hypertonia (HP:0002509)2.67104604
33Increased nuchal translucency (HP:0010880)2.63326001
34Selective tooth agenesis (HP:0001592)2.63201979
35Skin nodule (HP:0200036)2.61002455
36Intrahepatic cholestasis (HP:0001406)2.59132422
37Pheochromocytoma (HP:0002666)2.55173163
38Turricephaly (HP:0000262)2.55118253
39Decreased circulating renin level (HP:0003351)2.53574097
40Abnormality of the common coagulation pathway (HP:0010990)2.53093470
41Hypercortisolism (HP:0001578)2.47442391
42Prominent metopic ridge (HP:0005487)2.47404816
43Hyperparathyroidism (HP:0000843)2.46834839
44Deviation of the thumb (HP:0009603)2.46314692
45Retinal atrophy (HP:0001105)2.41822831
46Ulnar bowing (HP:0003031)2.38112320
47Abnormality of glycolysis (HP:0004366)2.34375188
48Thoracolumbar scoliosis (HP:0002944)2.33716051
49Xanthomatosis (HP:0000991)2.32022632
50Conjugated hyperbilirubinemia (HP:0002908)2.31997331
51Hypsarrhythmia (HP:0002521)2.28435974
52Cortical dysplasia (HP:0002539)2.26758302
53Spastic diplegia (HP:0001264)2.26299210
54Overlapping toe (HP:0001845)2.25754680
55Generalized aminoaciduria (HP:0002909)2.24833612
56Ankyloglossia (HP:0010296)2.24481419
57EEG with generalized epileptiform discharges (HP:0011198)2.23720208
58Shallow orbits (HP:0000586)2.23614888
59Proximal placement of thumb (HP:0009623)2.23155693
60Ankle contracture (HP:0006466)2.22250791
61Oligomenorrhea (HP:0000876)2.22093176
62Advanced eruption of teeth (HP:0006288)2.20766369
63Hand muscle atrophy (HP:0009130)2.19929764
64Epidermoid cyst (HP:0200040)2.18745225
65Termporal pattern (HP:0011008)2.17273201
66Insidious onset (HP:0003587)2.17273201
67Hypokalemia (HP:0002900)2.17104999
68Abnormality of monocarboxylic acid metabolism (HP:0010996)2.16747349
69Abnormality of oral frenula (HP:0000190)2.14071954
70Congenital glaucoma (HP:0001087)2.12937241
71Insomnia (HP:0100785)2.12343360
72Abnormality of dentin (HP:0010299)2.10191071
73Renal duplication (HP:0000075)2.06887315
74Resting tremor (HP:0002322)2.05261518
75Epileptiform EEG discharges (HP:0011182)2.04995232
76Growth hormone excess (HP:0000845)2.04458167
77Papilledema (HP:0001085)2.04315419
78Abnormality of the metopic suture (HP:0005556)2.02747309
79Neuroendocrine neoplasm (HP:0100634)2.02022474
80Abdominal distention (HP:0003270)2.01593481
81Atrophic scars (HP:0001075)2.01182785
82Septate vagina (HP:0001153)2.00462188
83Irritability (HP:0000737)1.99037564
84Back pain (HP:0003418)1.98156044
85Cerebral inclusion bodies (HP:0100314)1.97919350
86Dysautonomia (HP:0002459)1.96796710
87Impaired pain sensation (HP:0007328)1.96661808
88Abnormality of pain sensation (HP:0010832)1.96661808
89Hypotension (HP:0002615)1.96397102
90Unilateral renal agenesis (HP:0000122)1.96050213
91Missing ribs (HP:0000921)1.94142816
92Protuberant abdomen (HP:0001538)1.93819512
93Chromosomal breakage induced by crosslinking agents (HP:0003221)1.92722680
94Short nail (HP:0001799)1.92703022
95Disproportionate tall stature (HP:0001519)1.92259873
96Generalized hypotonia (HP:0001290)1.92016649
97Increased serum pyruvate (HP:0003542)1.91201592
98Exocrine pancreatic insufficiency (HP:0001738)1.90648210
99Natal tooth (HP:0000695)1.90463747
100Enlarged penis (HP:0000040)1.89444249
101Long palpebral fissure (HP:0000637)1.88149550
102Abnormality of purine metabolism (HP:0004352)1.86505706
103Postural tremor (HP:0002174)1.86165814
104Gout (HP:0001997)1.85881997
105Pterygium (HP:0001059)1.85330739
106Menstrual irregularities (HP:0000858)1.85309948
107Restlessness (HP:0000711)1.85148928
108Elfin facies (HP:0004428)1.82785420
109Orthostatic hypotension (HP:0001278)1.81969853
110Chromsome breakage (HP:0040012)1.81526476
111Hyperkalemia (HP:0002153)1.81496831
112Cortical visual impairment (HP:0100704)1.80912104
113Fragile skin (HP:0001030)1.79926714
114Flat acetabular roof (HP:0003180)1.77686195
115Bladder diverticulum (HP:0000015)1.76652131
116Abnormality of potassium homeostasis (HP:0011042)1.76600062
117Deep venous thrombosis (HP:0002625)1.76516402
118Vertebral compression fractures (HP:0002953)1.76391304
119Multiple enchondromatosis (HP:0005701)1.76088616
120Long toe (HP:0010511)1.75765872
121Myoglobinuria (HP:0002913)1.75301754
122Global brain atrophy (HP:0002283)1.74879302
123Arnold-Chiari malformation (HP:0002308)1.73986535
124Cerebral aneurysm (HP:0004944)1.73307074
125Trismus (HP:0000211)1.72673893
126Bowel diverticulosis (HP:0005222)1.72652181
127Neoplasm of the heart (HP:0100544)1.72623687
128Overriding aorta (HP:0002623)1.72348242
129Hypoplasia of the capital femoral epiphysis (HP:0003090)1.72062792
130Broad face (HP:0000283)1.71936464
131Elevated alkaline phosphatase (HP:0003155)1.70963062
132Wormian bones (HP:0002645)1.70907173
133Osteomalacia (HP:0002749)1.70256233
134Neurofibrillary tangles (HP:0002185)1.70170015
135Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.70009596
136Microglossia (HP:0000171)1.68971849
137Death in childhood (HP:0003819)1.68244707
138Abnormality of renin-angiotensin system (HP:0000847)1.67954370
139Abnormal foot bone ossification (HP:0010675)1.67464880
140Vertebral arch anomaly (HP:0008438)1.66809261
141Breech presentation (HP:0001623)1.66432956
142Severe short stature (HP:0003510)1.66109588
143Relative macrocephaly (HP:0004482)1.65688959
144Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.65014791
145Abnormality of the distal phalanx of the thumb (HP:0009617)1.64773866
146Glossoptosis (HP:0000162)1.64671441
147Abnormal ossification of hand bones (HP:0005921)1.64343997
148Generalized hyperpigmentation (HP:0007440)1.64321938
149Ependymoma (HP:0002888)1.64257553
150Abnormality of carpal bone ossification (HP:0006257)1.64081292
151Abnormal enzyme/coenzyme activity (HP:0012379)1.63897799
152Urethral obstruction (HP:0000796)1.63513637
153Abnormal biliary tract morphology (HP:0012440)1.63373759
154Abnormality of alkaline phosphatase activity (HP:0004379)1.63278339
155Osteolytic defects of the phalanges of the hand (HP:0009771)1.63091731
156Osteolytic defects of the hand bones (HP:0009699)1.63091731
157Spinal rigidity (HP:0003306)1.62943951
158Abnormality of the umbilical cord (HP:0010881)1.59761398
159Capillary hemangiomas (HP:0005306)1.59386639
160Thin bony cortex (HP:0002753)1.58983235
161Distal upper limb amyotrophy (HP:0007149)1.58822117
162Upper limb amyotrophy (HP:0009129)1.58822117
163Progressive neurologic deterioration (HP:0002344)1.57050420
164High anterior hairline (HP:0009890)1.55010191
165Patellar dislocation (HP:0002999)1.54896301
166Failure to thrive in infancy (HP:0001531)1.54863351
167Deep philtrum (HP:0002002)1.54807001
168Abnormality of the calcaneus (HP:0008364)1.54631216
169Nephroblastoma (Wilms tumor) (HP:0002667)1.54618342
170Aneurysm (HP:0002617)1.54169457
171Skull defect (HP:0001362)1.53411975
172Heterotopia (HP:0002282)1.53345514
173Hammertoe (HP:0001765)1.52703933
174Hypercholesterolemia (HP:0003124)1.51842344
175Achilles tendon contracture (HP:0001771)1.51648713
176Blue sclerae (HP:0000592)1.50860797
177Progressive hearing impairment (HP:0001730)1.50315531
178Cervical subluxation (HP:0003308)1.47764215
179Hepatoblastoma (HP:0002884)1.47115724
180Sparse lateral eyebrow (HP:0005338)1.46927491
181Embryonal renal neoplasm (HP:0011794)1.46802752
182Pseudobulbar signs (HP:0002200)1.46291119
183Tracheal stenosis (HP:0002777)1.46225298
184Leiomyosarcoma (HP:0100243)1.46075064
185Uterine leiomyosarcoma (HP:0002891)1.46075064
186Abnormal delivery (HP:0001787)1.45934130
187Renovascular hypertension (HP:0100817)1.45603895

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR5.46795875
2PASK5.08917389
3TRIB33.77669903
4SMG13.23981541
5TSSK62.88516248
6SIK12.79494257
7ERN12.78199757
8FLT32.70164320
9TAOK32.65418254
10CAMK1D2.60065920
11PRKD32.51795920
12TTK2.47367927
13HIPK22.43534229
14MAP3K22.40854992
15NTRK12.37995047
16MAPK152.37966736
17SCYL22.32374013
18BUB12.25753931
19PDGFRA2.23315894
20PKN22.20470501
21CAMK1G2.15132365
22LATS22.03663518
23MET2.02936761
24CDC71.98376610
25PTK61.97939948
26SRPK11.84826940
27NEK11.82100291
28PAK41.72977437
29FRK1.70809472
30EIF2AK11.66324800
31PBK1.55406096
32PTK21.54194721
33EPHA31.53496350
34TTN1.47508559
35FGFR41.47031134
36WNK41.45046365
37BCKDK1.42408212
38RET1.40496151
39UHMK11.36519902
40TAF11.26252862
41ERBB41.25003510
42MAP3K11.22818370
43CDK71.19682341
44PLK31.19591178
45RIPK11.18179810
46PRKCH1.09269538
47EEF2K1.08290383
48CHEK21.06487606
49MTOR1.06353894
50PAK31.05578142
51EPHB11.05560513
52BRSK11.04186175
53NME21.03073120
54CDK120.99565464
55WEE10.98883596
56CDC42BPA0.98878405
57KSR20.98083797
58MAP3K80.97605614
59DYRK1B0.96126028
60RPS6KB20.94652781
61MKNK10.93585188
62PNCK0.92604334
63CHEK10.91430384
64WNK30.90952240
65ICK0.86656710
66PLK10.85924985
67FER0.85244208
68PDGFRB0.81164320
69LMTK20.80590757
70MAP3K100.79421989
71ALK0.77567793
72FGFR20.76778049
73NTRK30.75662905
74AURKB0.75175497
75PRKAA10.74795244
76CAMKK20.74750755
77CLK10.73512822
78ATR0.73105532
79FGFR30.72539017
80JAK20.72392640
81VRK20.72313985
82AURKA0.70959252
83LATS10.70238527
84MAP2K20.69994396
85NEK20.69962465
86CDK40.68103814
87MST1R0.67021290
88WNK10.63534604
89RPS6KA20.62544690
90BRD40.62279615
91ATM0.61329532
92IRAK10.61033380
93TESK10.59072923
94STK40.59062213
95FGFR10.57860612
96* CDK10.57553246
97STK30.56484995
98BRAF0.56003873
99BRSK20.55632585
100JAK30.55376258
101AKT20.55134453
102EPHB20.53802120
103MKNK20.53777474
104MAP2K10.52952981
105EPHA20.51587800
106CDK90.50393362
107PLK40.50356194
108* CDK20.48953604
109JAK10.48950879
110EIF2AK20.48213114
111EIF2AK30.47719815
112PRKD10.47292674
113CDK180.46856556
114ITK0.46227724
115CDK150.45921862
116BCR0.45872312
117ARAF0.45767918
118CAMKK10.45295454
119KDR0.44868022
120MARK20.44621252
121KSR10.43868013
122ZAP700.43701237
123CSNK1E0.43627267
124CSNK1G10.42089823
125CDK140.41956134
126TRIM280.41563510
127CDK80.41491122
128PRKD20.41455160
129RPS6KB10.40384582
130CDK11A0.39759678
131IRAK20.37832496
132YES10.36263794
133PAK60.35893318
134* PRKACG0.35400629
135PRKAA20.35138110
136CDK60.34154981
137MARK10.33350403
138LIMK10.31728466
139MAP3K90.31350453
140CSNK1A1L0.30849009
141PRKDC0.28686807
142PAK20.28012387
143ERBB20.27628177
144INSR0.27536949
145PRKCI0.27193904
146LRRK20.24943617
147TYRO30.24468540
148CDK50.24408864
149PDPK10.24351464
150* IGF1R0.23319305
151CSNK1G20.22808811
152IRAK30.21986716
153PRKCE0.21727417
154MAP3K30.21274167
155MAPK90.20719673
156* MAPK140.19116153
157MAPK100.19007346
158MAPK10.18414913

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049507.80248017
2Protein export_Homo sapiens_hsa030603.27337346
3Sulfur metabolism_Homo sapiens_hsa009203.01120565
4Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.93673279
5Selenocompound metabolism_Homo sapiens_hsa004502.36510022
6DNA replication_Homo sapiens_hsa030302.31814201
7Type II diabetes mellitus_Homo sapiens_hsa049302.25527522
8Insulin secretion_Homo sapiens_hsa049112.23649245
9Vitamin B6 metabolism_Homo sapiens_hsa007501.99067333
10Fatty acid metabolism_Homo sapiens_hsa012121.96590817
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.93860471
12Non-homologous end-joining_Homo sapiens_hsa034501.83542940
13Butanoate metabolism_Homo sapiens_hsa006501.82892443
14Cell cycle_Homo sapiens_hsa041101.82116976
15Tryptophan metabolism_Homo sapiens_hsa003801.77853348
16Fatty acid biosynthesis_Homo sapiens_hsa000611.76761981
17Nitrogen metabolism_Homo sapiens_hsa009101.69348456
18Mismatch repair_Homo sapiens_hsa034301.59470065
19RNA transport_Homo sapiens_hsa030131.55182077
20Carbohydrate digestion and absorption_Homo sapiens_hsa049731.54181051
21Fatty acid degradation_Homo sapiens_hsa000711.50688420
22N-Glycan biosynthesis_Homo sapiens_hsa005101.48865212
23Pentose phosphate pathway_Homo sapiens_hsa000301.48338428
24Insulin resistance_Homo sapiens_hsa049311.45807532
25Adherens junction_Homo sapiens_hsa045201.42752682
26Propanoate metabolism_Homo sapiens_hsa006401.39150035
27Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.38334040
28Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.37996371
29Type I diabetes mellitus_Homo sapiens_hsa049401.31130691
30Spliceosome_Homo sapiens_hsa030401.29352148
31Vibrio cholerae infection_Homo sapiens_hsa051101.28306467
32Lysosome_Homo sapiens_hsa041421.26163891
33Steroid biosynthesis_Homo sapiens_hsa001001.22154642
34Glucagon signaling pathway_Homo sapiens_hsa049221.21222883
35Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.21203597
36mRNA surveillance pathway_Homo sapiens_hsa030151.20536653
37Base excision repair_Homo sapiens_hsa034101.20087146
38Fat digestion and absorption_Homo sapiens_hsa049751.19084427
39ABC transporters_Homo sapiens_hsa020101.14960625
40Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.12547259
41Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.11857200
42* Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.11607644
43Nucleotide excision repair_Homo sapiens_hsa034201.10325506
44Pyruvate metabolism_Homo sapiens_hsa006201.09190266
45AMPK signaling pathway_Homo sapiens_hsa041521.09065283
46Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.08883060
47Cocaine addiction_Homo sapiens_hsa050301.08021416
48MicroRNAs in cancer_Homo sapiens_hsa052061.07152131
49Fatty acid elongation_Homo sapiens_hsa000621.05604334
50Glycosaminoglycan degradation_Homo sapiens_hsa005311.05314862
51PPAR signaling pathway_Homo sapiens_hsa033201.05180692
52Lysine degradation_Homo sapiens_hsa003101.04020056
53Insulin signaling pathway_Homo sapiens_hsa049101.01012895
54Hippo signaling pathway_Homo sapiens_hsa043901.01006103
55ECM-receptor interaction_Homo sapiens_hsa045121.00354044
56Small cell lung cancer_Homo sapiens_hsa052220.99174250
57Phenylalanine metabolism_Homo sapiens_hsa003600.98576656
58Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.97061853
59Fructose and mannose metabolism_Homo sapiens_hsa000510.95076525
60Tyrosine metabolism_Homo sapiens_hsa003500.93875749
61Cysteine and methionine metabolism_Homo sapiens_hsa002700.93366791
62Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.92874999
63Prion diseases_Homo sapiens_hsa050200.91500688
64Focal adhesion_Homo sapiens_hsa045100.88012186
65mTOR signaling pathway_Homo sapiens_hsa041500.87988060
66Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.87707972
67Proteoglycans in cancer_Homo sapiens_hsa052050.87504933
68Prolactin signaling pathway_Homo sapiens_hsa049170.86297725
69Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.83235169
70Galactose metabolism_Homo sapiens_hsa000520.82763450
71Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.81885060
72Thyroid hormone signaling pathway_Homo sapiens_hsa049190.80902131
73Primary bile acid biosynthesis_Homo sapiens_hsa001200.80680454
74Folate biosynthesis_Homo sapiens_hsa007900.80578490
75Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.80186198
76Starch and sucrose metabolism_Homo sapiens_hsa005000.78892228
77Adipocytokine signaling pathway_Homo sapiens_hsa049200.76811352
78Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.73624218
79Thyroid hormone synthesis_Homo sapiens_hsa049180.72433577
80Histidine metabolism_Homo sapiens_hsa003400.71412010
81Tight junction_Homo sapiens_hsa045300.69235049
82Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.68631651
83Cyanoamino acid metabolism_Homo sapiens_hsa004600.68351006
84Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.68239964
85Central carbon metabolism in cancer_Homo sapiens_hsa052300.68024049
86Basal cell carcinoma_Homo sapiens_hsa052170.67899280
87Oocyte meiosis_Homo sapiens_hsa041140.67336323
88Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.66876509
89p53 signaling pathway_Homo sapiens_hsa041150.66299722
90Pyrimidine metabolism_Homo sapiens_hsa002400.65553327
91Pancreatic cancer_Homo sapiens_hsa052120.64519297
92Colorectal cancer_Homo sapiens_hsa052100.63690713
93Bile secretion_Homo sapiens_hsa049760.63679505
94Estrogen signaling pathway_Homo sapiens_hsa049150.62836063
95Glycerolipid metabolism_Homo sapiens_hsa005610.62453400
96Aldosterone synthesis and secretion_Homo sapiens_hsa049250.62059345
97Glioma_Homo sapiens_hsa052140.60495555
98Arginine biosynthesis_Homo sapiens_hsa002200.60238201
99Non-small cell lung cancer_Homo sapiens_hsa052230.59488850
100Longevity regulating pathway - mammal_Homo sapiens_hsa042110.58409839
101Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.57933175
102Carbon metabolism_Homo sapiens_hsa012000.57895108
103Peroxisome_Homo sapiens_hsa041460.57005266
104Pancreatic secretion_Homo sapiens_hsa049720.56742933
1052-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.55457245
106Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.54975430
107Wnt signaling pathway_Homo sapiens_hsa043100.54401386
108TGF-beta signaling pathway_Homo sapiens_hsa043500.52352666
109Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.50690780
110Thyroid cancer_Homo sapiens_hsa052160.48743880
111Drug metabolism - other enzymes_Homo sapiens_hsa009830.47923678
112Arginine and proline metabolism_Homo sapiens_hsa003300.46330191
113Other glycan degradation_Homo sapiens_hsa005110.45407078
114ErbB signaling pathway_Homo sapiens_hsa040120.45322460
115Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.45225359
116Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.45094575
117Viral carcinogenesis_Homo sapiens_hsa052030.44754671
118Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.43549461
119Melanoma_Homo sapiens_hsa052180.41851025
120Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.41783454
121Dopaminergic synapse_Homo sapiens_hsa047280.41715751
122Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.41106568
123Hedgehog signaling pathway_Homo sapiens_hsa043400.40390800
124Axon guidance_Homo sapiens_hsa043600.39887029
125Complement and coagulation cascades_Homo sapiens_hsa046100.39160271
126Regulation of actin cytoskeleton_Homo sapiens_hsa048100.38430734
127Pathways in cancer_Homo sapiens_hsa052000.37630444
128Notch signaling pathway_Homo sapiens_hsa043300.37165667
129Inositol phosphate metabolism_Homo sapiens_hsa005620.36912031
130RNA polymerase_Homo sapiens_hsa030200.36798623
131Bladder cancer_Homo sapiens_hsa052190.36509101
132Cholinergic synapse_Homo sapiens_hsa047250.35560939
133Biosynthesis of amino acids_Homo sapiens_hsa012300.34430763
134Neurotrophin signaling pathway_Homo sapiens_hsa047220.34319170
135Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.34169185
136Endometrial cancer_Homo sapiens_hsa052130.33793231
137Renal cell carcinoma_Homo sapiens_hsa052110.33603413
138Circadian rhythm_Homo sapiens_hsa047100.33540372
139Dorso-ventral axis formation_Homo sapiens_hsa043200.33247976
140Chronic myeloid leukemia_Homo sapiens_hsa052200.31832713
141Alcoholism_Homo sapiens_hsa050340.31454977
142alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.30982230
143Regulation of autophagy_Homo sapiens_hsa041400.30053503
144Caffeine metabolism_Homo sapiens_hsa002320.29751295
145Amphetamine addiction_Homo sapiens_hsa050310.28913792
146Prostate cancer_Homo sapiens_hsa052150.27777635
147Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.27693557
148beta-Alanine metabolism_Homo sapiens_hsa004100.27067971
149Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.26865366
150One carbon pool by folate_Homo sapiens_hsa006700.26449486
151Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.26183893
152Ovarian steroidogenesis_Homo sapiens_hsa049130.23004857

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