ACMSD

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The neuronal excitotoxin quinolinate is an intermediate in the de novo synthesis pathway of NAD from tryptophan, and has been implicated in the pathogenesis of several neurodegenerative disorders. Quinolinate is derived from alpha-amino-beta-carboxy-muconate-epsilon-semialdehyde (ACMS). ACMSD (ACMS decarboxylase; EC 4.1.1.45) can divert ACMS to a benign catabolite and thus prevent the accumulation of quinolinate from ACMS. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1omega-hydroxylase P450 pathway (GO:0097267)8.32990959
2epoxygenase P450 pathway (GO:0019373)8.22973123
3L-phenylalanine catabolic process (GO:0006559)7.57995227
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.57995227
5L-phenylalanine metabolic process (GO:0006558)7.28355333
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.28355333
7* aromatic amino acid family catabolic process (GO:0009074)7.05491708
8glyoxylate metabolic process (GO:0046487)6.85043280
9* indole-containing compound catabolic process (GO:0042436)6.61581724
10* indolalkylamine catabolic process (GO:0046218)6.61581724
11* tryptophan catabolic process (GO:0006569)6.61581724
12urate metabolic process (GO:0046415)6.39822724
13drug transmembrane transport (GO:0006855)6.33610480
14fibrinolysis (GO:0042730)6.22660722
15* tryptophan metabolic process (GO:0006568)6.19582007
16oxidative demethylation (GO:0070989)6.18934385
17lysine metabolic process (GO:0006553)6.14086668
18lysine catabolic process (GO:0006554)6.14086668
19cysteine metabolic process (GO:0006534)6.13796660
20kynurenine metabolic process (GO:0070189)6.00998240
21blood coagulation, intrinsic pathway (GO:0007597)5.80917927
22homocysteine metabolic process (GO:0050667)5.70610140
23serine family amino acid catabolic process (GO:0009071)5.67722234
24fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.40489174
25bile acid biosynthetic process (GO:0006699)5.39234026
26drug transport (GO:0015893)5.29082702
27drug catabolic process (GO:0042737)5.21753613
28phenylpropanoid metabolic process (GO:0009698)5.14463487
29urea metabolic process (GO:0019627)5.14000239
30urea cycle (GO:0000050)5.14000239
31exogenous drug catabolic process (GO:0042738)5.07162332
32* aromatic amino acid family metabolic process (GO:0009072)5.06508528
33S-adenosylmethionine metabolic process (GO:0046500)5.01021075
34sulfur amino acid catabolic process (GO:0000098)5.00560297
35amino-acid betaine metabolic process (GO:0006577)4.98115570
36regulation of plasminogen activation (GO:0010755)4.94947883
37ethanol metabolic process (GO:0006067)4.85453053
38* alpha-amino acid catabolic process (GO:1901606)4.81857539
39serine family amino acid metabolic process (GO:0009069)4.80745282
40nitrogen cycle metabolic process (GO:0071941)4.76851815
41protein activation cascade (GO:0072376)4.74095158
42negative regulation of blood coagulation (GO:0030195)4.67027909
43negative regulation of hemostasis (GO:1900047)4.67027909
44cellular glucuronidation (GO:0052695)4.65954487
45* cellular biogenic amine catabolic process (GO:0042402)4.65082921
46* amine catabolic process (GO:0009310)4.65082921
47* indolalkylamine metabolic process (GO:0006586)4.62840213
48cellular modified amino acid catabolic process (GO:0042219)4.58294847
49tyrosine metabolic process (GO:0006570)4.52181958
50benzene-containing compound metabolic process (GO:0042537)4.51777720
51* cellular amino acid catabolic process (GO:0009063)4.51183607
52alkaloid metabolic process (GO:0009820)4.44850910
53complement activation, alternative pathway (GO:0006957)4.43711339
54glucuronate metabolic process (GO:0019585)4.42941238
55uronic acid metabolic process (GO:0006063)4.42941238
56bile acid metabolic process (GO:0008206)4.41238255
57serine family amino acid biosynthetic process (GO:0009070)4.39963738
58complement activation (GO:0006956)4.38443196
59phospholipid efflux (GO:0033700)4.34781976
60short-chain fatty acid metabolic process (GO:0046459)4.34567297
61regulation of protein activation cascade (GO:2000257)4.30673503
62complement activation, classical pathway (GO:0006958)4.30625447
63acute-phase response (GO:0006953)4.27036790
64aldehyde catabolic process (GO:0046185)4.26050752
65regulation of humoral immune response (GO:0002920)4.25937591
66aminoglycoside antibiotic metabolic process (GO:0030647)4.25805474
67negative regulation of protein activation cascade (GO:2000258)4.25362360
68negative regulation of coagulation (GO:0050819)4.23709087
69glutamate metabolic process (GO:0006536)4.21264661
70negative regulation of wound healing (GO:0061045)4.20632578
71peptidyl-glutamic acid carboxylation (GO:0017187)4.20610286
72protein carboxylation (GO:0018214)4.20610286
73organic cation transport (GO:0015695)4.18872221
74triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.18647141
75cholesterol efflux (GO:0033344)4.17114285
76aspartate family amino acid catabolic process (GO:0009068)4.14945601
77response to mercury ion (GO:0046689)4.13595177
78coenzyme catabolic process (GO:0009109)4.13531746
79cellular ketone body metabolic process (GO:0046950)4.10796688
80plasma lipoprotein particle remodeling (GO:0034369)4.09516748
81protein-lipid complex remodeling (GO:0034368)4.09516748
82macromolecular complex remodeling (GO:0034367)4.09516748
83glycine metabolic process (GO:0006544)4.09448502
84negative regulation of fibrinolysis (GO:0051918)4.08775779
85regulation of complement activation (GO:0030449)4.05666373
86NAD biosynthetic process (GO:0009435)4.04120905
87regulation of fibrinolysis (GO:0051917)4.01277351
88opsonization (GO:0008228)3.97207554
89alpha-linolenic acid metabolic process (GO:0036109)3.95980877
90cytolysis (GO:0019835)3.94809550
91* organic acid catabolic process (GO:0016054)3.93570278
92* carboxylic acid catabolic process (GO:0046395)3.93570278
93high-density lipoprotein particle remodeling (GO:0034375)3.90670740
94acetyl-CoA metabolic process (GO:0006084)3.88070849
95positive regulation of lipoprotein lipase activity (GO:0051006)3.87223132
96positive regulation of triglyceride lipase activity (GO:0061365)3.87223132
97positive regulation of blood coagulation (GO:0030194)3.85855367
98positive regulation of hemostasis (GO:1900048)3.85855367
99intestinal cholesterol absorption (GO:0030299)3.84739185
100nicotinamide nucleotide biosynthetic process (GO:0019359)3.83590082
101pyridine nucleotide biosynthetic process (GO:0019363)3.83590082
102negative regulation of lipase activity (GO:0060192)3.82372631
103reverse cholesterol transport (GO:0043691)3.81706572
104arginine metabolic process (GO:0006525)3.81572480
1052-oxoglutarate metabolic process (GO:0006103)3.81160285
106branched-chain amino acid metabolic process (GO:0009081)3.79748127
107heme transport (GO:0015886)3.79136949
108valine metabolic process (GO:0006573)3.78469377
109daunorubicin metabolic process (GO:0044597)3.78101373
110polyketide metabolic process (GO:0030638)3.78101373
111doxorubicin metabolic process (GO:0044598)3.78101373
112carnitine metabolic process (GO:0009437)3.74622648
113positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.73648576
114hormone catabolic process (GO:0042447)3.72357624
115dicarboxylic acid biosynthetic process (GO:0043650)3.71964405
116disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.71898455
117killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.71898455
118flavonoid metabolic process (GO:0009812)3.71813902
119bile acid and bile salt transport (GO:0015721)3.71395170
120acylglycerol homeostasis (GO:0055090)3.70650720
121triglyceride homeostasis (GO:0070328)3.70650720
122fatty acid beta-oxidation (GO:0006635)3.68390071
123imidazole-containing compound metabolic process (GO:0052803)3.67689150
124fat-soluble vitamin biosynthetic process (GO:0042362)3.67430827
125fatty acid oxidation (GO:0019395)3.67053814
126branched-chain amino acid catabolic process (GO:0009083)3.66873829
127phosphate ion transport (GO:0006817)3.66710553
128response to nitrosative stress (GO:0051409)3.66210196
129xenobiotic metabolic process (GO:0006805)3.65391070
130* indole-containing compound metabolic process (GO:0042430)3.64713958
131lipid oxidation (GO:0034440)3.60515888
132regulation of bile acid biosynthetic process (GO:0070857)3.60355075
133ethanol oxidation (GO:0006069)3.59128378
134positive regulation of coagulation (GO:0050820)3.58190995
135regulation of triglyceride catabolic process (GO:0010896)3.56812567
136amino acid salvage (GO:0043102)3.56496505
137L-methionine salvage (GO:0071267)3.56496505
138L-methionine biosynthetic process (GO:0071265)3.56496505
139steroid catabolic process (GO:0006706)3.55358832
140fructose metabolic process (GO:0006000)3.53264678
141ketone body metabolic process (GO:1902224)3.52356172
142monocarboxylic acid catabolic process (GO:0072329)3.51872717
143regulation of cholesterol esterification (GO:0010872)3.46406335
144cofactor catabolic process (GO:0051187)3.43371641
145drug metabolic process (GO:0017144)3.40686167
146proline metabolic process (GO:0006560)3.40229169
147negative regulation of cholesterol transport (GO:0032375)3.39349395
148negative regulation of sterol transport (GO:0032372)3.39349395
149fatty acid catabolic process (GO:0009062)3.38371900

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse7.69155228
2EGR1_23403033_ChIP-Seq_LIVER_Mouse7.07574655
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.51006401
4* LXR_22158963_ChIP-Seq_LIVER_Mouse5.83882354
5CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.81382861
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.77495198
7CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.04346394
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.81569686
9PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.60105495
10FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.01835197
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.78888272
12HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.30095212
13IGF1R_20145208_ChIP-Seq_DFB_Human2.17480205
14TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.12373385
15ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.8741934
16ESR1_20079471_ChIP-ChIP_T-47D_Human1.88334629
17IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.85156686
18TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.78176397
19IRF8_22096565_ChIP-ChIP_GC-B_Human1.71636723
20POU3F2_20337985_ChIP-ChIP_501MEL_Human1.57711334
21NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.56966595
22STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.55675986
23BCAT_22108803_ChIP-Seq_LS180_Human1.54832959
24* HNF4A_19822575_ChIP-Seq_HepG2_Human1.49063631
25GATA1_22025678_ChIP-Seq_K562_Human1.42404484
26TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.41847562
27FOXA2_19822575_ChIP-Seq_HepG2_Human1.40900472
28ER_23166858_ChIP-Seq_MCF-7_Human1.33334267
29KAP1_22055183_ChIP-Seq_ESCs_Mouse1.29951739
30PHF8_20622853_ChIP-Seq_HELA_Human1.27922245
31CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.23133068
32KLF5_20875108_ChIP-Seq_MESCs_Mouse1.21910347
33IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.20914121
34CBP_20019798_ChIP-Seq_JUKART_Human1.20914121
35ESR1_21235772_ChIP-Seq_MCF-7_Human1.18775028
36TP53_18474530_ChIP-ChIP_U2OS_Human1.18013769
37NFYA_21822215_ChIP-Seq_K562_Human1.17669754
38CTBP1_25329375_ChIP-Seq_LNCAP_Human1.17499588
39HTT_18923047_ChIP-ChIP_STHdh_Human1.16954958
40RXRA_24833708_ChIP-Seq_LIVER_Mouse1.15538923
41Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.11725369
42PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.11511627
43ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.10298520
44GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.08228455
45GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.05930284
46SUZ12_27294783_Chip-Seq_NPCs_Mouse1.03698257
47ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.03588016
48GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.03306328
49CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.99224431
50UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.97294098
51* EZH2_27294783_Chip-Seq_NPCs_Mouse0.96500234
52GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96470616
53GATA6_21074721_ChIP-Seq_CACO-2_Human0.95926630
54ETV1_20927104_ChIP-Seq_GIST48_Human0.95926151
55CTBP2_25329375_ChIP-Seq_LNCAP_Human0.95405672
56* NFE2_27457419_Chip-Seq_LIVER_Mouse0.94813163
57PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.94310991
58GATA4_25053715_ChIP-Seq_YYC3_Human0.94037918
59FLI1_27457419_Chip-Seq_LIVER_Mouse0.93170529
60AR_20517297_ChIP-Seq_VCAP_Human0.91846886
61RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.90705183
62NFYB_21822215_ChIP-Seq_K562_Human0.90568010
63STAT3_23295773_ChIP-Seq_U87_Human0.89606883
64TBL1_22424771_ChIP-Seq_293T_Human0.89223651
65* CBX2_22325352_ChIP-Seq_293T-Rex_Human0.88573892
66TAF15_26573619_Chip-Seq_HEK293_Human0.87955861
67IRF1_19129219_ChIP-ChIP_H3396_Human0.87912255
68PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.87417465
69TCF4_22108803_ChIP-Seq_LS180_Human0.87220833
70STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.86746099
71EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.86065856
72SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.85267118
73ZFP57_27257070_Chip-Seq_ESCs_Mouse0.84776618
74SMAD4_21741376_ChIP-Seq_EPCs_Human0.84633785
75* FOXA1_25552417_ChIP-Seq_VCAP_Human0.84561786
76RARG_19884340_ChIP-ChIP_MEFs_Mouse0.83796295
77FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.83784762
78ERG_20517297_ChIP-Seq_VCAP_Human0.83489338
79* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.82981593
80STAT1_17558387_ChIP-Seq_HELA_Human0.82958441
81P300_19829295_ChIP-Seq_ESCs_Human0.82116621
82RBPJ_21746931_ChIP-Seq_IB4_Human0.81782462
83ETV2_25802403_ChIP-Seq_MESCs_Mouse0.81744050
84* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.81674410
85CLOCK_20551151_ChIP-Seq_293T_Human0.81643404
86AR_25329375_ChIP-Seq_VCAP_Human0.81518481
87MYC_19829295_ChIP-Seq_ESCs_Human0.81009268
88AUTS2_25519132_ChIP-Seq_293T-REX_Human0.80427540
89RAC3_21632823_ChIP-Seq_H3396_Human0.80310963
90CDX2_20551321_ChIP-Seq_CACO-2_Human0.80195308
91ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.80078386
92SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.79081650
93PCGF2_27294783_Chip-Seq_ESCs_Mouse0.78266107
94* CRX_20693478_ChIP-Seq_RETINA_Mouse0.78191379
95* RUNX2_22187159_ChIP-Seq_PCA_Human0.77463361
96SOX2_27498859_Chip-Seq_STOMACH_Mouse0.76477382
97SMAD3_21741376_ChIP-Seq_EPCs_Human0.76221482
98MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.76048147
99TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.75858393
100POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.75858393
101FOXA1_21572438_ChIP-Seq_LNCaP_Human0.75713864
102* RUNX1_27457419_Chip-Seq_LIVER_Mouse0.75568495
103ERA_21632823_ChIP-Seq_H3396_Human0.74662242
104BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.73682558
105* SMAD4_21799915_ChIP-Seq_A2780_Human0.72944327
106SRF_21415370_ChIP-Seq_HL-1_Mouse0.72529167
107* PCGF2_27294783_Chip-Seq_NPCs_Mouse0.72041268
108NCOR_22424771_ChIP-Seq_293T_Human0.70998093
109FOXA1_27270436_Chip-Seq_PROSTATE_Human0.70776309
110FOXA1_25329375_ChIP-Seq_VCAP_Human0.70776309
111CDX2_19796622_ChIP-Seq_MESCs_Mouse0.70667377
112EGR1_19032775_ChIP-ChIP_M12_Human0.69104858
113GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.68932756
114ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.68054753
115NRF2_20460467_ChIP-Seq_MEFs_Mouse0.67627365
116NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.67627365
117RAD21_21589869_ChIP-Seq_MESCs_Mouse0.67572310
118* OCT4_21477851_ChIP-Seq_ESCs_Mouse0.67328371
119TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.67322725
120* ESRRB_18555785_Chip-Seq_ESCs_Mouse0.66666891
121CEBPB_22108803_ChIP-Seq_LS180_Human0.66446834
122CDX2_22108803_ChIP-Seq_LS180_Human0.65344120
123* OCT4_18555785_Chip-Seq_ESCs_Mouse0.64165369
124PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.63153695
125* SMAD1_18555785_Chip-Seq_ESCs_Mouse0.62037472
126* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.61899021
127LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.61129583
128PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.60039320
129IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.59370956
130SALL4_18804426_ChIP-ChIP_XEN_Mouse0.59238980
131* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.58785053
132PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.58727889
133GBX2_23144817_ChIP-Seq_PC3_Human0.58429289
134RARA_24833708_ChIP-Seq_LIVER_Mouse0.58124522
135FOXH1_21741376_ChIP-Seq_EPCs_Human0.58098365
136BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.57718061
137AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.57717347
138* STAT3_18555785_Chip-Seq_ESCs_Mouse0.57576821
139* P53_22387025_ChIP-Seq_ESCs_Mouse0.57348772
140ESET_19884257_ChIP-Seq_ESCs_Mouse0.57224208
141PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.56793288
142GATA1_19941827_ChIP-Seq_MEL_Mouse0.56589436
143* ZFX_18555785_Chip-Seq_ESCs_Mouse0.56235964
144* PIAS1_25552417_ChIP-Seq_VCAP_Human0.56199477
145CBP_21632823_ChIP-Seq_H3396_Human0.55962248
146HNFA_21074721_ChIP-Seq_CACO-2_Human0.55075884
147NANOG_19829295_ChIP-Seq_ESCs_Human0.54970035
148SOX2_19829295_ChIP-Seq_ESCs_Human0.54970035
149* SUZ12_18555785_Chip-Seq_ESCs_Mouse0.54677905
150* PU1_27457419_Chip-Seq_LIVER_Mouse0.54071160
151* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.53631181
152MYC_19915707_ChIP-ChIP_AK7_Human0.52747629
153TAF2_19829295_ChIP-Seq_ESCs_Human0.52531677
154* KLF4_18555785_Chip-Seq_ESCs_Mouse0.51356729
155THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.50781219

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis8.28272448
2MP0002139_abnormal_hepatobiliary_system7.60500204
3MP0005085_abnormal_gallbladder_physiolo5.67440390
4MP0005365_abnormal_bile_salt5.35640874
5MP0008875_abnormal_xenobiotic_pharmacok4.55590148
6MP0005332_abnormal_amino_acid3.81886717
7MP0003252_abnormal_bile_duct3.71970540
8MP0003195_calcinosis3.54971578
9MP0003806_abnormal_nucleotide_metabolis3.49824281
10MP0004019_abnormal_vitamin_homeostasis3.46617993
11MP0002138_abnormal_hepatobiliary_system3.14047665
12MP0010329_abnormal_lipoprotein_level2.64161172
13MP0009643_abnormal_urine_homeostasis2.31273471
14MP0004043_abnormal_pH_regulation2.26622874
15MP0005083_abnormal_biliary_tract2.18420584
16MP0001666_abnormal_nutrient_absorption2.06481419
17MP0003191_abnormal_cellular_cholesterol2.01123377
18MP0003186_abnormal_redox_activity1.94983321
19MP0005636_abnormal_mineral_homeostasis1.92551326
20MP0001764_abnormal_homeostasis1.89788050
21MP0005319_abnormal_enzyme/_coenzyme1.84022958
22MP0009840_abnormal_foam_cell1.78218139
23MP0000609_abnormal_liver_physiology1.72476337
24MP0002118_abnormal_lipid_homeostasis1.68147069
25MP0005584_abnormal_enzyme/coenzyme_acti1.67009724
26MP0009697_abnormal_copulation1.54561377
27MP0002876_abnormal_thyroid_physiology1.53928351
28MP0005451_abnormal_body_composition1.46839918
29MP0005084_abnormal_gallbladder_morpholo1.45316153
30MP0001756_abnormal_urination1.42753506
31MP0002136_abnormal_kidney_physiology1.40373366
32MP0001765_abnormal_ion_homeostasis1.38387960
33MP0009764_decreased_sensitivity_to1.38189240
34MP0004147_increased_porphyrin_level1.37040073
35MP0003868_abnormal_feces_composition1.31560674
36MP0003656_abnormal_erythrocyte_physiolo1.26037597
37MP0005670_abnormal_white_adipose1.16180087
38MP0006036_abnormal_mitochondrial_physio1.05785133
39MP0008469_abnormal_protein_level1.03345530
40MP0000598_abnormal_liver_morphology1.02317128
41MP0005647_abnormal_sex_gland1.01970872
42MP0005408_hypopigmentation0.98892463
43MP0005187_abnormal_penis_morphology0.98112247
44MP0002928_abnormal_bile_duct0.96510304
45MP0009053_abnormal_anal_canal0.95533744
46MP0009642_abnormal_blood_homeostasis0.94816095
47MP0003879_abnormal_hair_cell0.90780760
48MP0003724_increased_susceptibility_to0.87996748
49MP0009763_increased_sensitivity_to0.87957290
50MP0005058_abnormal_lysosome_morphology0.87532063
51MP0005535_abnormal_body_temperature0.84817732
52MP0002282_abnormal_trachea_morphology0.83424314
53MP0000538_abnormal_urinary_bladder0.82501972
54MP0005410_abnormal_fertilization0.82384565
55MP0005220_abnormal_exocrine_pancreas0.82186656
56MP0003011_delayed_dark_adaptation0.82160410
57MP0004782_abnormal_surfactant_physiolog0.80506147
58MP0009765_abnormal_xenobiotic_induced0.76729428
59MP0005395_other_phenotype0.70212151
60MP0005376_homeostasis/metabolism_phenot0.69483990
61MP0004381_abnormal_hair_follicle0.66602937
62MP0002078_abnormal_glucose_homeostasis0.63931269
63MP0002168_other_aberrant_phenotype0.62191103
64MP0001915_intracranial_hemorrhage0.60691939
65MP0003718_maternal_effect0.60674550
66MP0000230_abnormal_systemic_arterial0.60322014
67MP0002249_abnormal_larynx_morphology0.57684378
68MP0006035_abnormal_mitochondrial_morpho0.57342494
69MP0002135_abnormal_kidney_morphology0.56084051
70MP0009780_abnormal_chondrocyte_physiolo0.51899688
71MP0000371_diluted_coat_color0.50136396
72MP0002254_reproductive_system_inflammat0.49567142
73MP0010368_abnormal_lymphatic_system0.49408410
74MP0001661_extended_life_span0.48334421
75MP0003436_decreased_susceptibility_to0.47708587
76MP0008260_abnormal_autophagy0.47187898
77MP0005334_abnormal_fat_pad0.47030237
78MP0005464_abnormal_platelet_physiology0.46734210
79MP0005266_abnormal_metabolism0.46727691
80MP0003638_abnormal_response/metabolism_0.46487000
81MP0001845_abnormal_inflammatory_respons0.45411075
82MP0003953_abnormal_hormone_level0.43420686
83MP0005377_hearing/vestibular/ear_phenot0.43395348
84MP0003878_abnormal_ear_physiology0.43395348
85MP0009379_abnormal_foot_pigmentation0.41838213
86MP0002090_abnormal_vision0.41441575
87MP0005448_abnormal_energy_balance0.40953008
88MP0005075_abnormal_melanosome_morpholog0.40945927
89MP0003632_abnormal_nervous_system0.39437413
90MP0002971_abnormal_brown_adipose0.38338209
91MP0004264_abnormal_extraembryonic_tissu0.37997253
92MP0005166_decreased_susceptibility_to0.37566321
93MP0001984_abnormal_olfaction0.37512641
94MP0005551_abnormal_eye_electrophysiolog0.37423008
95MP0001944_abnormal_pancreas_morphology0.36794596
96MP0002132_abnormal_respiratory_system0.36727987
97MP0008872_abnormal_physiological_respon0.35888641
98MP0000604_amyloidosis0.33280787
99MP0010386_abnormal_urinary_bladder0.32969365
100MP0000467_abnormal_esophagus_morphology0.31606733
101MP0009785_altered_susceptibility_to0.31249406
102MP0003880_abnormal_central_pattern0.30720841
103MP0003690_abnormal_glial_cell0.30085924
104MP0003943_abnormal_hepatobiliary_system0.29451050
105MP0000566_synostosis0.29129182
106MP0003698_abnormal_male_reproductive0.28510123
107MP0003075_altered_response_to0.28408808
108MP0008873_increased_physiological_sensi0.28273010
109MP0003633_abnormal_nervous_system0.28168406
110MP0004142_abnormal_muscle_tone0.27826088
111MP0001119_abnormal_female_reproductive0.27397275
112MP0001542_abnormal_bone_strength0.27195639
113MP0003631_nervous_system_phenotype0.27184284
114MP0001929_abnormal_gametogenesis0.26848241
115MP0006082_CNS_inflammation0.26844277
116MP0002837_dystrophic_cardiac_calcinosis0.26839931
117MP0002098_abnormal_vibrissa_morphology0.25735837
118MP0002069_abnormal_eating/drinking_beha0.25654462
119MP0008874_decreased_physiological_sensi0.25565641
120MP0005646_abnormal_pituitary_gland0.25274567
121MP0000367_abnormal_coat/_hair0.24736226
122MP0005666_abnormal_adipose_tissue0.24499011
123MP0009384_cardiac_valve_regurgitation0.24437764
124MP0004883_abnormal_blood_vessel0.24365720
125MP0009115_abnormal_fat_cell0.24355597
126MP0001835_abnormal_antigen_presentation0.24055473
127MP0005164_abnormal_response_to0.23980368
128MP0002909_abnormal_adrenal_gland0.23893909
129MP0005248_abnormal_Harderian_gland0.23797403
130MP0000249_abnormal_blood_vessel0.23719592
131MP0002697_abnormal_eye_size0.21244296
132MP0000639_abnormal_adrenal_gland0.20945961
133MP0005379_endocrine/exocrine_gland_phen0.20331310

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)6.04452463
2Intrahepatic cholestasis (HP:0001406)5.53466385
3Abnormality of glutamine family amino acid metabolism (HP:0010902)5.29172198
4Abnormality of monocarboxylic acid metabolism (HP:0010996)5.23197981
5Hyperglycinuria (HP:0003108)4.90066571
6Gout (HP:0001997)4.86149295
7Glomerulonephritis (HP:0000099)4.85026881
8Prolonged partial thromboplastin time (HP:0003645)4.64229906
9Xanthomatosis (HP:0000991)4.52884554
10Deep venous thrombosis (HP:0002625)4.37100302
11Abnormality of glycine metabolism (HP:0010895)4.32037282
12Abnormality of serine family amino acid metabolism (HP:0010894)4.32037282
13Spontaneous abortion (HP:0005268)4.31319096
14Abnormality of aspartate family amino acid metabolism (HP:0010899)4.29393145
15Proximal tubulopathy (HP:0000114)4.22280803
16Hyperglycinemia (HP:0002154)4.22243946
17Hyperammonemia (HP:0001987)4.14289449
18Ketosis (HP:0001946)4.11396087
19Complement deficiency (HP:0004431)4.10510257
20Abnormality of sulfur amino acid metabolism (HP:0004339)3.94202266
21Abnormality of purine metabolism (HP:0004352)3.93956899
22Abnormality of nucleobase metabolism (HP:0010932)3.92988643
23Abnormality of pyrimidine metabolism (HP:0004353)3.91052132
24Joint hemorrhage (HP:0005261)3.90849966
25Hypobetalipoproteinemia (HP:0003563)3.75773224
26Generalized aminoaciduria (HP:0002909)3.71636419
27Alkalosis (HP:0001948)3.59021448
28Nephritis (HP:0000123)3.54226819
29Hyperuricemia (HP:0002149)3.46719126
30Increased purine levels (HP:0004368)3.46719126
31Abnormality of fatty-acid metabolism (HP:0004359)3.40961790
32Ketoacidosis (HP:0001993)3.40929972
33Conjugated hyperbilirubinemia (HP:0002908)3.40920277
34Abnormality of methionine metabolism (HP:0010901)3.40019453
35Fat malabsorption (HP:0002630)3.27425686
36Hyperlipoproteinemia (HP:0010980)3.26445382
37Increased circulating renin level (HP:0000848)3.24506408
38Hyperactive renin-angiotensin system (HP:0000841)3.22729879
39Epidermoid cyst (HP:0200040)3.20877478
40Hypokalemic alkalosis (HP:0001949)3.19557895
41Abnormality of serum amino acid levels (HP:0003112)3.18784656
42Hypoglycemic coma (HP:0001325)3.17622203
43Delayed CNS myelination (HP:0002188)3.16212666
44Vascular calcification (HP:0004934)3.14145330
45Glycosuria (HP:0003076)3.09731032
46Abnormality of urine glucose concentration (HP:0011016)3.09731032
47Osteomalacia (HP:0002749)3.09646260
48Abnormality of the common coagulation pathway (HP:0010990)3.09344135
49Metabolic alkalosis (HP:0200114)3.05363658
50Mitral stenosis (HP:0001718)2.99158037
51Metabolic acidosis (HP:0001942)2.99036828
52Hypomagnesemia (HP:0002917)2.97246764
53Abnormality of complement system (HP:0005339)2.96125426
54Hypercholesterolemia (HP:0003124)2.93984207
55Reduced antithrombin III activity (HP:0001976)2.93819033
56Polyuria (HP:0000103)2.93615431
57Enlarged kidneys (HP:0000105)2.92474253
58Lethargy (HP:0001254)2.92263140
59Hyperbilirubinemia (HP:0002904)2.92052857
60Dicarboxylic aciduria (HP:0003215)2.90957136
61Abnormality of dicarboxylic acid metabolism (HP:0010995)2.90957136
62Abnormal urine output (HP:0012590)2.89812040
63Abnormality of chloride homeostasis (HP:0011422)2.85563655
64Abnormality of renal excretion (HP:0011036)2.80904410
65Systemic lupus erythematosus (HP:0002725)2.80688948
66Hydroxyprolinuria (HP:0003080)2.78427102
67Abnormality of proline metabolism (HP:0010907)2.78427102
68Hypolipoproteinemia (HP:0010981)2.77255968
69Hepatocellular carcinoma (HP:0001402)2.73181289
70Cardiovascular calcification (HP:0011915)2.72931854
71Abnormality of the intrinsic pathway (HP:0010989)2.69793047
72Abnormality of vitamin metabolism (HP:0100508)2.67064657
73Rickets (HP:0002748)2.65667996
74Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.61603643
75Renal tubular acidosis (HP:0001947)2.60360819
76Cerebral edema (HP:0002181)2.55789926
77Vomiting (HP:0002013)2.55611867
78Gingival bleeding (HP:0000225)2.55504293
79Abnormality of magnesium homeostasis (HP:0004921)2.53225916
80Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.50196472
81Steatorrhea (HP:0002570)2.48540608
82Renal cortical cysts (HP:0000803)2.47166668
83Abnormal enzyme/coenzyme activity (HP:0012379)2.46539408
84Hypoalphalipoproteinemia (HP:0003233)2.42059673
85Hyperphosphaturia (HP:0003109)2.39663151
86Irritability (HP:0000737)2.33484652
87Abnormality of alkaline phosphatase activity (HP:0004379)2.27861368
88Thrombophlebitis (HP:0004418)2.27690777
89Polydipsia (HP:0001959)2.25747586
90Abnormal drinking behavior (HP:0030082)2.25747586
91Nephrolithiasis (HP:0000787)2.22909522
92Nausea (HP:0002018)2.22637610
93Fair hair (HP:0002286)2.22074678
94Pancreatitis (HP:0001733)2.20796252
95Hypoglycemic seizures (HP:0002173)2.20290882
96Neonatal onset (HP:0003623)2.19862052
97Abnormal urine phosphate concentration (HP:0012599)2.18738538
98Hemorrhage of the eye (HP:0011885)2.18541575
99Sensorimotor neuropathy (HP:0007141)2.18076613
100Malnutrition (HP:0004395)2.15742142
101Elevated alkaline phosphatase (HP:0003155)2.15063574
102Hypophosphatemia (HP:0002148)2.11465893
103Bifid scrotum (HP:0000048)2.10899941
104Arthropathy (HP:0003040)2.10525127
105Hypochromic microcytic anemia (HP:0004840)2.10020321
106Recurrent gram-negative bacterial infections (HP:0005420)2.08632173
107Tetany (HP:0001281)2.07712631
108Confusion (HP:0001289)2.07213542
109Abnormality of renin-angiotensin system (HP:0000847)2.06735654
110Hypophosphatemic rickets (HP:0004912)2.03903580
111Hyperaldosteronism (HP:0000859)2.02960776
112Menorrhagia (HP:0000132)2.01922014
113Opisthotonus (HP:0002179)2.00434488
114Myocardial infarction (HP:0001658)1.97157614
115Alveolar cell carcinoma (HP:0006519)1.96941507
116Pulmonary embolism (HP:0002204)1.96510614
117Abnormal biliary tract physiology (HP:0012439)1.95861439
118Bile duct proliferation (HP:0001408)1.95861439
119Abnormal gallbladder morphology (HP:0012437)1.92921177
120Cholelithiasis (HP:0001081)1.91692313
121Purpura (HP:0000979)1.90198512
122Abnormality of the Achilles tendon (HP:0005109)1.79340414
123Joint swelling (HP:0001386)1.76232225
124Poikilocytosis (HP:0004447)1.61985441
125Potter facies (HP:0002009)1.54112550
126Facial shape deformation (HP:0011334)1.54112550
127Cerebral palsy (HP:0100021)1.51738889
128Cholecystitis (HP:0001082)1.50455068
129Abnormal gallbladder physiology (HP:0012438)1.50455068
130Gangrene (HP:0100758)1.47396215
131Abnormality of iron homeostasis (HP:0011031)1.47394309
132Abnormality of transition element cation homeostasis (HP:0011030)1.45884737

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.54399804
2WNK45.08311245
3WNK35.01395696
4OXSR13.91269429
5PNCK3.21232514
6INSRR3.11505465
7STK38L2.98956849
8FGFR42.76275377
9IRAK32.74277390
10MAP3K142.29637285
11BRSK22.18124645
12ERBB42.07092320
13EPHA31.98947437
14RIPK11.95869325
15PINK11.95351706
16ERN11.92200726
17TNIK1.84350373
18MAPK111.83028130
19SGK2231.78105128
20SGK4941.78105128
21SGK21.75647530
22ZAK1.70335734
23MARK31.64500345
24TAOK31.63200379
25CSNK1G11.49492990
26PRKCG1.46116895
27MST1R1.42525304
28TYK21.35704586
29MAP3K41.34055234
30STK391.33906186
31SGK31.27068668
32NTRK31.22843979
33PIK3CA1.22639205
34EPHA41.22391678
35EIF2AK31.21731500
36MUSK1.20830079
37NEK21.18238558
38CAMKK21.16525617
39SIK11.15238939
40MAP2K41.11785787
41ACVR1B1.03981166
42CSNK1G31.03764596
43RPS6KA51.03121058
44IRAK41.02155644
45TGFBR21.01812324
46FRK1.01725851
47CASK1.01308451
48NEK91.00343724
49MAP2K30.99185845
50FER0.98330103
51PIK3CG0.98137420
52MAP3K30.96629982
53TLK10.94357092
54STK160.92911398
55PDK20.89816488
56MAP4K20.89493903
57IKBKE0.89424953
58ABL20.89278482
59EIF2AK10.89181768
60TXK0.85727296
61AKT30.83901627
62PRKAA20.83658862
63CDK90.83122240
64OBSCN0.83097184
65CSNK1A1L0.82672151
66PRKG10.82220532
67CSNK1G20.81502173
68MAP2K60.80539394
69EIF2AK20.80300489
70PKN20.78611094
71DYRK20.78534423
72PDK30.78216219
73PDK40.78216219
74GRK60.77840185
75NLK0.77682491
76IRAK10.76805356
77TIE10.76749699
78TAOK20.76599795
79JAK10.76426013
80GRK10.74872553
81IGF1R0.73736036
82IRAK20.73246487
83CSNK1A10.71938764
84MAPKAPK30.70767907
85MAPK70.69680007
86JAK20.69323942
87ADRBK20.68811975
88IKBKB0.66326326
89MAP3K70.65361448
90MAP2K70.64943493
91PRKCE0.64851979
92PRKACA0.64485660
93CSNK1D0.63769614
94CDK80.63350756
95CHUK0.60558642
96GSK3A0.60088984
97PIM10.59634044
98PRKAA10.57134782
99RET0.56563949
100VRK10.56451356
101MAPK120.55861270
102CSNK1E0.55240408
103GRK70.55226022
104STK380.55112749
105WEE10.54892996
106TBK10.54784186
107MAP3K60.54648452
108FLT30.54121114
109RPS6KB10.50751225
110MAPK150.50579402
111ERBB20.50043608
112MAPK40.49961676
113FGFR30.49604542
114FGFR20.48612866
115PBK0.47946242
116BCR0.47319262
117STK240.46783024
118PRKCZ0.46410023
119PRKACG0.45838016
120WNK10.45831294
121BMPR20.45628707
122TNK20.45595106
123MET0.44805678
124SIK30.44609373
125SGK10.44524876
126PRKCQ0.44257643
127DAPK20.43995896
128NEK10.43763744
129BRSK10.42990855
130NUAK10.42568429
131PLK40.42070857
132KDR0.39027792
133MAP3K50.38678951
134MYLK0.38551227
135CSNK2A10.37025207
136PRKCB0.36905269
137PRKCD0.36825182
138PRKCA0.36591908
139NME20.36057616
140RPS6KA30.36016702
141YES10.35998253
142PKN10.35693854
143PDPK10.35436511
144PRPF4B0.34039591
145CAMK2G0.33993653
146DYRK1B0.33394262
147LATS10.33347695
148BMPR1B0.32963972
149PRKACB0.32063242
150CDK30.31812878
151PIM20.30115830
152STK40.28748735
153LYN0.27898555

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.80794802
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.54906373
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.32605541
4Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.83026440
5Pentose and glucuronate interconversions_Homo sapiens_hsa000402.80192876
6* Tryptophan metabolism_Homo sapiens_hsa003802.65787582
7Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.64778126
8Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.63874252
9Arginine biosynthesis_Homo sapiens_hsa002202.59231607
10Butanoate metabolism_Homo sapiens_hsa006502.56528267
11Peroxisome_Homo sapiens_hsa041462.45207497
12Fatty acid degradation_Homo sapiens_hsa000712.39144247
13Nitrogen metabolism_Homo sapiens_hsa009102.32566782
14Propanoate metabolism_Homo sapiens_hsa006402.29494102
15Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.22787197
16Complement and coagulation cascades_Homo sapiens_hsa046102.14482928
17Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.09085003
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.98578726
19beta-Alanine metabolism_Homo sapiens_hsa004101.95307879
20Steroid hormone biosynthesis_Homo sapiens_hsa001401.92335646
21Cyanoamino acid metabolism_Homo sapiens_hsa004601.84004534
22Histidine metabolism_Homo sapiens_hsa003401.81284386
23Chemical carcinogenesis_Homo sapiens_hsa052041.75408962
24Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.74577699
25Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.73858833
262-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.73614381
27Fatty acid metabolism_Homo sapiens_hsa012121.73070576
28Selenocompound metabolism_Homo sapiens_hsa004501.68911212
29Phenylalanine metabolism_Homo sapiens_hsa003601.66915793
30Drug metabolism - other enzymes_Homo sapiens_hsa009831.64085228
31Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.63588272
32Pyruvate metabolism_Homo sapiens_hsa006201.61811841
33Retinol metabolism_Homo sapiens_hsa008301.57011315
34PPAR signaling pathway_Homo sapiens_hsa033201.56398607
35Sulfur metabolism_Homo sapiens_hsa009201.54299139
36Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.51731645
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.46008431
38Starch and sucrose metabolism_Homo sapiens_hsa005001.45427354
39Vitamin digestion and absorption_Homo sapiens_hsa049771.41071644
40Staphylococcus aureus infection_Homo sapiens_hsa051501.36506534
41Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.35090953
42Folate biosynthesis_Homo sapiens_hsa007901.34593347
43Bile secretion_Homo sapiens_hsa049761.32717783
44Tyrosine metabolism_Homo sapiens_hsa003501.28379100
45Cysteine and methionine metabolism_Homo sapiens_hsa002701.28009390
46Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.27423211
47Fatty acid elongation_Homo sapiens_hsa000621.25872392
48Arginine and proline metabolism_Homo sapiens_hsa003301.23591152
49Carbon metabolism_Homo sapiens_hsa012001.20909845
50Maturity onset diabetes of the young_Homo sapiens_hsa049501.19699741
51Glutathione metabolism_Homo sapiens_hsa004801.15108875
52Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.11680070
53Biosynthesis of amino acids_Homo sapiens_hsa012301.11559033
54Caffeine metabolism_Homo sapiens_hsa002321.09467544
55ABC transporters_Homo sapiens_hsa020101.01092049
56Vitamin B6 metabolism_Homo sapiens_hsa007500.97203119
57Lysine degradation_Homo sapiens_hsa003100.96169815
58Steroid biosynthesis_Homo sapiens_hsa001000.94789525
59Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.93907554
60One carbon pool by folate_Homo sapiens_hsa006700.87185526
61Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.70676481
62Sulfur relay system_Homo sapiens_hsa041220.65950416
63* Metabolic pathways_Homo sapiens_hsa011000.61383310
64Glycerolipid metabolism_Homo sapiens_hsa005610.60830024
65Fat digestion and absorption_Homo sapiens_hsa049750.57068514
66Pentose phosphate pathway_Homo sapiens_hsa000300.53586835
67Fructose and mannose metabolism_Homo sapiens_hsa000510.44857323
68Collecting duct acid secretion_Homo sapiens_hsa049660.31628696
69Arachidonic acid metabolism_Homo sapiens_hsa005900.30138783
70Other glycan degradation_Homo sapiens_hsa005110.28475012
71Glycosaminoglycan degradation_Homo sapiens_hsa005310.21812822
72alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.20691694
73Pertussis_Homo sapiens_hsa051330.19043287
74Galactose metabolism_Homo sapiens_hsa000520.18436415
75Regulation of autophagy_Homo sapiens_hsa041400.12825071
76Prion diseases_Homo sapiens_hsa050200.11942756
77Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.09421120
78Mineral absorption_Homo sapiens_hsa049780.07689126
79Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.07443504
80Protein digestion and absorption_Homo sapiens_hsa049740.07231453
81Linoleic acid metabolism_Homo sapiens_hsa005910.04236989
82Oxidative phosphorylation_Homo sapiens_hsa001900.03760582
83Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.03548031
84Fatty acid biosynthesis_Homo sapiens_hsa000610.03533133
85Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.01914857
86Circadian rhythm_Homo sapiens_hsa047100.01858150
87Serotonergic synapse_Homo sapiens_hsa047260.01773704
88Insulin resistance_Homo sapiens_hsa049310.00250293
89TGF-beta signaling pathway_Homo sapiens_hsa04350-0.2052696
90Cocaine addiction_Homo sapiens_hsa05030-0.2005968
91GABAergic synapse_Homo sapiens_hsa04727-0.2000022
92Amoebiasis_Homo sapiens_hsa05146-0.1919160
93Vascular smooth muscle contraction_Homo sapiens_hsa04270-0.1734418
94N-Glycan biosynthesis_Homo sapiens_hsa00510-0.1581886
95Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1566491
96Pyrimidine metabolism_Homo sapiens_hsa00240-0.1549846
97Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1465030
98Ether lipid metabolism_Homo sapiens_hsa00565-0.1451526
99Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563-0.1338099
100Ovarian steroidogenesis_Homo sapiens_hsa04913-0.1291480
101Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1203972
102RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622-0.1077338
103Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1060835
104Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512-0.0928262
105Glucagon signaling pathway_Homo sapiens_hsa04922-0.0899897
106Sphingolipid metabolism_Homo sapiens_hsa00600-0.0857643
107Hepatitis C_Homo sapiens_hsa05160-0.0830192
108Intestinal immune network for IgA production_Homo sapiens_hsa04672-0.0505926
109Glycerophospholipid metabolism_Homo sapiens_hsa00564-0.0456017
110Adipocytokine signaling pathway_Homo sapiens_hsa04920-0.0428397
111AMPK signaling pathway_Homo sapiens_hsa04152-0.0422194
112Lysosome_Homo sapiens_hsa04142-0.0369256
113Renin-angiotensin system_Homo sapiens_hsa04614-0.0253718

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