

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | positive regulation by symbiont of host defense response (GO:0052509) | 6.71359704 |
| 2 | modulation by symbiont of host defense response (GO:0052031) | 6.71359704 |
| 3 | modulation by organism of immune response of other organism involved in symbiotic interaction (GO:00 | 6.71359704 |
| 4 | modulation by organism of defense response of other organism involved in symbiotic interaction (GO:0 | 6.71359704 |
| 5 | positive regulation by organism of defense response of other organism involved in symbiotic interact | 6.71359704 |
| 6 | modulation by symbiont of host immune response (GO:0052553) | 6.71359704 |
| 7 | response to peptidoglycan (GO:0032494) | 6.16679427 |
| 8 | positive regulation of chemokine biosynthetic process (GO:0045080) | 5.85036425 |
| 9 | regulation of cytokine secretion involved in immune response (GO:0002739) | 5.29453492 |
| 10 | neutrophil activation involved in immune response (GO:0002283) | 5.03702704 |
| 11 | positive regulation of heat generation (GO:0031652) | 4.99783509 |
| 12 | positive regulation of interferon-alpha production (GO:0032727) | 4.98314900 |
| 13 | lipopolysaccharide-mediated signaling pathway (GO:0031663) | 4.92034258 |
| 14 | regulation of chemokine biosynthetic process (GO:0045073) | 4.91354679 |
| 15 | regulation of interferon-alpha production (GO:0032647) | 4.80993437 |
| 16 | macrophage activation involved in immune response (GO:0002281) | 4.78872371 |
| 17 | regulation of fever generation (GO:0031620) | 4.78306188 |
| 18 | branching involved in labyrinthine layer morphogenesis (GO:0060670) | 4.66976766 |
| 19 | hydrogen peroxide biosynthetic process (GO:0050665) | 4.64152368 |
| 20 | response to host immune response (GO:0052572) | 4.51832222 |
| 21 | response to immune response of other organism involved in symbiotic interaction (GO:0052564) | 4.51832222 |
| 22 | positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770) | 4.37947185 |
| 23 | respiratory burst (GO:0045730) | 4.34333960 |
| 24 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G | 4.29045973 |
| 25 | cellular response to type I interferon (GO:0071357) | 4.21472630 |
| 26 | type I interferon signaling pathway (GO:0060337) | 4.21472630 |
| 27 | positive regulation of heterotypic cell-cell adhesion (GO:0034116) | 4.20135098 |
| 28 | response to type I interferon (GO:0034340) | 4.16807993 |
| 29 | immunoglobulin mediated immune response (GO:0016064) | 4.14122242 |
| 30 | reactive oxygen species biosynthetic process (GO:1903409) | 4.09752825 |
| 31 | positive regulation of interleukin-8 biosynthetic process (GO:0045416) | 4.07314862 |
| 32 | response to defenses of other organism involved in symbiotic interaction (GO:0052173) | 4.01423139 |
| 33 | response to host (GO:0075136) | 4.01423139 |
| 34 | response to host defenses (GO:0052200) | 4.01423139 |
| 35 | negative regulation of viral genome replication (GO:0045071) | 4.01191172 |
| 36 | response to muramyl dipeptide (GO:0032495) | 3.99508163 |
| 37 | superoxide anion generation (GO:0042554) | 3.97826060 |
| 38 | regulation of interferon-beta biosynthetic process (GO:0045357) | 3.90328713 |
| 39 | regulation of T-helper cell differentiation (GO:0045622) | 3.88906270 |
| 40 | regulation of immunoglobulin secretion (GO:0051023) | 3.86582414 |
| 41 | granulocyte activation (GO:0036230) | 3.86368790 |
| 42 | microglial cell activation (GO:0001774) | 3.85912337 |
| 43 | positive regulation of cellular amide metabolic process (GO:0034250) | 3.81871937 |
| 44 | negative regulation of amino acid transport (GO:0051956) | 3.80753898 |
| 45 | negative regulation of toll-like receptor 4 signaling pathway (GO:0034144) | 3.78033072 |
| 46 | regulation of nitric oxide biosynthetic process (GO:0045428) | 3.77334887 |
| 47 | regulation of podosome assembly (GO:0071801) | 3.74504800 |
| 48 | regulation of heat generation (GO:0031650) | 3.74468891 |
| 49 | regulation of interleukin-12 production (GO:0032655) | 3.72880667 |
| 50 | positive regulation of T-helper cell differentiation (GO:0045624) | 3.72771174 |
| 51 | regulation of T-helper 1 cell differentiation (GO:0045625) | 3.72599653 |
| 52 | positive regulation of interferon-beta production (GO:0032728) | 3.68526740 |
| 53 | response to protozoan (GO:0001562) | 3.67798996 |
| 54 | detection of molecule of bacterial origin (GO:0032490) | 3.63394962 |
| 55 | positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725) | 3.62234738 |
| 56 | regulation of membrane protein ectodomain proteolysis (GO:0051043) | 3.61648784 |
| 57 | myeloid dendritic cell differentiation (GO:0043011) | 3.60336712 |
| 58 | natural killer cell mediated cytotoxicity (GO:0042267) | 3.59501190 |
| 59 | natural killer cell mediated immunity (GO:0002228) | 3.59501190 |
| 60 | regulation of vitamin D biosynthetic process (GO:0060556) | 3.57379517 |
| 61 | response to interferon-alpha (GO:0035455) | 3.56278182 |
| 62 | regulation of mononuclear cell migration (GO:0071675) | 3.55635563 |
| 63 | NIK/NF-kappaB signaling (GO:0038061) | 3.53325178 |
| 64 | regulation of type 2 immune response (GO:0002828) | 3.53297083 |
| 65 | negative regulation of interleukin-12 production (GO:0032695) | 3.52674339 |
| 66 | negative regulation of nitric oxide biosynthetic process (GO:0045019) | 3.52228890 |
| 67 | positive regulation of membrane protein ectodomain proteolysis (GO:0051044) | 3.52020449 |
| 68 | regulation of interleukin-8 biosynthetic process (GO:0045414) | 3.51708612 |
| 69 | positive regulation of toll-like receptor signaling pathway (GO:0034123) | 3.49260866 |
| 70 | interferon-gamma-mediated signaling pathway (GO:0060333) | 3.49146118 |
| 71 | positive regulation of acute inflammatory response (GO:0002675) | 3.48484184 |
| 72 | positive regulation of type 2 immune response (GO:0002830) | 3.45029717 |
| 73 | neutrophil activation (GO:0042119) | 3.43061112 |
| 74 | macrophage activation (GO:0042116) | 3.42179177 |
| 75 | myeloid cell activation involved in immune response (GO:0002275) | 3.42150309 |
| 76 | negative regulation of growth of symbiont in host (GO:0044130) | 3.41383259 |
| 77 | negative regulation of growth of symbiont involved in interaction with host (GO:0044146) | 3.41383259 |
| 78 | modulation of growth of symbiont involved in interaction with host (GO:0044144) | 3.41383259 |
| 79 | regulation of growth of symbiont in host (GO:0044126) | 3.41383259 |
| 80 | kynurenine metabolic process (GO:0070189) | 3.41331977 |
| 81 | germinal center formation (GO:0002467) | 3.41123710 |
| 82 | regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370) | 3.40684688 |
| 83 | leukocyte aggregation (GO:0070486) | 3.39935903 |
| 84 | positive regulation of defense response to virus by host (GO:0002230) | 3.39154949 |
| 85 | negative regulation of myeloid cell apoptotic process (GO:0033033) | 3.38333210 |
| 86 | regulation of chronic inflammatory response (GO:0002676) | 3.37215929 |
| 87 | cellular response to interferon-beta (GO:0035458) | 3.37162681 |
| 88 | regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923) | 3.36973032 |
| 89 | defense response to protozoan (GO:0042832) | 3.35910645 |
| 90 | regulation of heterotypic cell-cell adhesion (GO:0034114) | 3.35627514 |
| 91 | positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372) | 3.35108037 |
| 92 | regulation of type I interferon-mediated signaling pathway (GO:0060338) | 3.35090789 |
| 93 | regulation of dendritic cell antigen processing and presentation (GO:0002604) | 3.34679416 |
| 94 | positive regulation of gamma-delta T cell activation (GO:0046645) | 3.34596225 |
| 95 | cellular response to nicotine (GO:0071316) | 3.34389617 |
| 96 | positive regulation of cAMP-mediated signaling (GO:0043950) | 3.32466177 |
| 97 | regulation of interferon-gamma biosynthetic process (GO:0045072) | 3.31261357 |
| 98 | T-helper 1 type immune response (GO:0042088) | 3.30106030 |
| 99 | positive regulation of NF-kappaB import into nucleus (GO:0042346) | 3.29679048 |
| 100 | positive regulation of chemokine production (GO:0032722) | 3.29030264 |
| 101 | positive regulation of antigen processing and presentation (GO:0002579) | 3.28429636 |
| 102 | regulation of NF-kappaB import into nucleus (GO:0042345) | 3.28291499 |
| 103 | positive regulation of natural killer cell differentiation (GO:0032825) | 3.27917934 |
| 104 | regulation of tumor necrosis factor biosynthetic process (GO:0042534) | 3.27481001 |
| 105 | low-density lipoprotein particle clearance (GO:0034383) | 3.27224958 |
| 106 | cellular response to interferon-alpha (GO:0035457) | 3.26796306 |
| 107 | regulation of syncytium formation by plasma membrane fusion (GO:0060142) | 3.25427419 |
| 108 | lymphocyte chemotaxis (GO:0048247) | 3.23937923 |
| 109 | regulation of nitric-oxide synthase biosynthetic process (GO:0051769) | 3.23780527 |
| 110 | tryptophan catabolic process (GO:0006569) | 3.23507514 |
| 111 | indole-containing compound catabolic process (GO:0042436) | 3.23507514 |
| 112 | indolalkylamine catabolic process (GO:0046218) | 3.23507514 |
| 113 | positive regulation of nitric oxide biosynthetic process (GO:0045429) | 3.23296850 |
| 114 | positive regulation of mast cell activation involved in immune response (GO:0033008) | 3.23025562 |
| 115 | positive regulation of mast cell degranulation (GO:0043306) | 3.23025562 |
| 116 | antigen processing and presentation of endogenous peptide antigen (GO:0002483) | 3.22768197 |
| 117 | antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885) | 3.22768197 |
| 118 | interferon-gamma secretion (GO:0072643) | 3.22013581 |
| 119 | regulation of T cell tolerance induction (GO:0002664) | 3.21869233 |
| 120 | positive regulation of syncytium formation by plasma membrane fusion (GO:0060143) | 3.21175115 |
| 121 | regulation of antigen processing and presentation (GO:0002577) | 3.20501392 |
| 122 | regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645) | 3.19444268 |
| 123 | activation of MAPKKK activity (GO:0000185) | 3.17421229 |
| 124 | regulation of vitamin metabolic process (GO:0030656) | 3.15154546 |
| 125 | cellular response to virus (GO:0098586) | 3.15114928 |
| 126 | negative regulation of interleukin-17 production (GO:0032700) | 3.14518433 |
| 127 | positive regulation of interleukin-6 production (GO:0032755) | 3.14174539 |
| 128 | I-kappaB phosphorylation (GO:0007252) | 3.13500148 |
| 129 | regulation of T-helper 2 cell differentiation (GO:0045628) | 3.12935644 |
| 130 | cellular response to exogenous dsRNA (GO:0071360) | 3.12255855 |
| 131 | regulation of T-helper 1 type immune response (GO:0002825) | 3.11506589 |
| 132 | response to interferon-beta (GO:0035456) | 3.11463893 |
| 133 | dendritic cell differentiation (GO:0097028) | 3.10879642 |
| 134 | negative regulation of inflammatory response to antigenic stimulus (GO:0002862) | 3.10529429 |
| 135 | cellular response to lipopolysaccharide (GO:0071222) | 3.10009689 |
| 136 | positive regulation of interleukin-2 biosynthetic process (GO:0045086) | 3.09498388 |
| 137 | positive regulation of interferon-gamma biosynthetic process (GO:0045078) | 3.09256200 |
| 138 | cellular response to molecule of bacterial origin (GO:0071219) | 3.08929118 |
| 139 | regulation of inflammatory response to antigenic stimulus (GO:0002861) | 3.08749989 |
| 140 | eosinophil chemotaxis (GO:0048245) | 3.08252722 |
| 141 | positive regulation of interleukin-12 production (GO:0032735) | 3.07860350 |
| 142 | positive regulation of inflammatory response to antigenic stimulus (GO:0002863) | 3.05870255 |
| 143 | monocyte chemotaxis (GO:0002548) | 3.05279320 |
| 144 | T cell migration (GO:0072678) | 3.05199938 |
| 145 | B cell mediated immunity (GO:0019724) | 3.04095962 |
| 146 | negative regulation of lipid storage (GO:0010888) | 3.04094586 |
| 147 | negative regulation of cytokine production involved in immune response (GO:0002719) | 3.03733228 |
| 148 | regulation of RIG-I signaling pathway (GO:0039535) | 3.02477771 |
| 149 | myeloid dendritic cell activation (GO:0001773) | 3.02035132 |
| 150 | negative regulation of production of molecular mediator of immune response (GO:0002701) | 3.00150443 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 7.84445588 |
| 2 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 7.76373581 |
| 3 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 6.80145065 |
| 4 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 5.60655831 |
| 5 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 4.68140335 |
| 6 | IRF8_27001747_Chip-Seq_BMDM_Mouse | 4.56479802 |
| 7 | SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse | 4.11377212 |
| 8 | Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse | 3.83406695 |
| 9 | NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse | 3.81053833 |
| 10 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 3.75661694 |
| 11 | MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 2.94737368 |
| 12 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 2.91284618 |
| 13 | MYB_21317192_ChIP-Seq_ERMYB_Mouse | 2.81349917 |
| 14 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 2.68980375 |
| 15 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 2.64854138 |
| 16 | STAT3_20064451_ChIP-Seq_CD4+T_Mouse | 2.57620380 |
| 17 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 2.55430676 |
| 18 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 2.51128737 |
| 19 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 2.14759484 |
| 20 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 2.05082437 |
| 21 | STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse | 2.01855156 |
| 22 | PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.90911116 |
| 23 | BRD4_27068464_Chip-Seq_AML-cells_Mouse | 1.86449258 |
| 24 | SPI1_23547873_ChIP-Seq_NB4_Human | 1.81565069 |
| 25 | CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.71928393 |
| 26 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 1.69524796 |
| 27 | CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse | 1.66002688 |
| 28 | GATA1_22025678_ChIP-Seq_K562_Human | 1.64086117 |
| 29 | VDR_24787735_ChIP-Seq_THP-1_Human | 1.60657979 |
| 30 | PU_27001747_Chip-Seq_BMDM_Mouse | 1.59124439 |
| 31 | STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse | 1.57162608 |
| 32 | ESR2_21235772_ChIP-Seq_MCF-7_Human | 1.56442233 |
| 33 | KLF2_18264089_ChIP-ChIP_MESCs_Mouse | 1.51478025 |
| 34 | KLF5_18264089_ChIP-ChIP_MESCs_Mouse | 1.51478025 |
| 35 | KLF4_18264089_ChIP-ChIP_MESCs_Mouse | 1.51478025 |
| 36 | PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse | 1.48006398 |
| 37 | VDR_24763502_ChIP-Seq_THP-1_Human | 1.46254497 |
| 38 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 1.45018302 |
| 39 | SPI1_23127762_ChIP-Seq_K562_Human | 1.37944915 |
| 40 | CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse | 1.35979846 |
| 41 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.35183879 |
| 42 | RUNX1_22412390_ChIP-Seq_EML_Mouse | 1.32812757 |
| 43 | MYB_26560356_Chip-Seq_TH2_Human | 1.30808543 |
| 44 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.27793421 |
| 45 | TP63_17297297_ChIP-ChIP_HaCaT_Human | 1.27579445 |
| 46 | CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse | 1.27553241 |
| 47 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 1.27471966 |
| 48 | ESR1_21235772_ChIP-Seq_MCF-7_Human | 1.27163027 |
| 49 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 1.25170258 |
| 50 | MAF_26560356_Chip-Seq_TH1_Human | 1.20496673 |
| 51 | RUNX_20019798_ChIP-Seq_JUKART_Human | 1.19497112 |
| 52 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 1.17610226 |
| 53 | PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse | 1.16178036 |
| 54 | NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human | 1.15978935 |
| 55 | TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 1.13362575 |
| 56 | CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse | 1.12685560 |
| 57 | VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human | 1.12310999 |
| 58 | GATA3_26560356_Chip-Seq_TH2_Human | 1.11315285 |
| 59 | SCL_19346495_ChIP-Seq_HPC-7_Human | 1.10348765 |
| 60 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 1.10138894 |
| 61 | SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.10045605 |
| 62 | TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 1.10041946 |
| 63 | GATA2_21666600_ChIP-Seq_HMVEC_Human | 1.09651040 |
| 64 | PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse | 1.07530007 |
| 65 | FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse | 1.04849160 |
| 66 | EGR1_19032775_ChIP-ChIP_M12_Human | 1.04260753 |
| 67 | STAT1_20625510_ChIP-Seq_HELA_Human | 1.03552979 |
| 68 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 1.02594374 |
| 69 | NRF2_20460467_ChIP-Seq_MEFs_Mouse | 1.02472215 |
| 70 | NFE2L2_20460467_ChIP-Seq_MEFs_Mouse | 1.02472215 |
| 71 | MEIS1_20887958_ChIP-Seq_HPC-7_Mouse | 1.02104180 |
| 72 | TRIM28_21343339_ChIP-Seq_HEK293_Human | 1.01278510 |
| 73 | MYB_26560356_Chip-Seq_TH1_Human | 1.00157354 |
| 74 | GATA3_27048872_Chip-Seq_THYMUS_Human | 0.98066173 |
| 75 | TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse | 0.95415095 |
| 76 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.94878241 |
| 77 | SOX2_20726797_ChIP-Seq_SW620_Human | 0.94815685 |
| 78 | LMO2_20887958_ChIP-Seq_HPC-7_Mouse | 0.93519826 |
| 79 | GATA2_22383799_ChIP-Seq_G1ME_Mouse | 0.92496675 |
| 80 | GATA1_19941827_ChIP-Seq_MEL_Mouse | 0.92176758 |
| 81 | KDM2B_26808549_Chip-Seq_DND41_Human | 0.89003231 |
| 82 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.86256112 |
| 83 | E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human | 0.85808407 |
| 84 | TCF7_22412390_ChIP-Seq_EML_Mouse | 0.83545575 |
| 85 | CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human | 0.82427969 |
| 86 | JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 0.79826066 |
| 87 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.78250923 |
| 88 | GATA2_20887958_ChIP-Seq_HPC-7_Mouse | 0.78134918 |
| 89 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 0.77953502 |
| 90 | UTX_26944678_Chip-Seq_JUKART_Human | 0.77912257 |
| 91 | VDR_21846776_ChIP-Seq_THP-1_Human | 0.75533856 |
| 92 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 0.75273683 |
| 93 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 0.74969973 |
| 94 | CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse | 0.74935483 |
| 95 | BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human | 0.72675437 |
| 96 | JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 0.72581527 |
| 97 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 0.72485831 |
| 98 | KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 0.71842539 |
| 99 | LXR_22292898_ChIP-Seq_THP-1_Human | 0.69930090 |
| 100 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 0.68774374 |
| 101 | FOXO1_23066095_ChIP-Seq_LIVER_Mouse | 0.68493782 |
| 102 | RXR_22158963_ChIP-Seq_LIVER_Mouse | 0.68027384 |
| 103 | KDM2B_26808549_Chip-Seq_K562_Human | 0.67449011 |
| 104 | SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.66971600 |
| 105 | TFEB_21752829_ChIP-Seq_HELA_Human | 0.66871543 |
| 106 | LXR_22158963_ChIP-Seq_LIVER_Mouse | 0.66825669 |
| 107 | SMAD2_18955504_ChIP-ChIP_HaCaT_Human | 0.66593612 |
| 108 | SMAD3_18955504_ChIP-ChIP_HaCaT_Human | 0.66593612 |
| 109 | ATF3_23680149_ChIP-Seq_GBM1-GSC_Human | 0.66320956 |
| 110 | GATA1_19941827_ChIP-Seq_MEL86_Mouse | 0.66278521 |
| 111 | MAF_26560356_Chip-Seq_TH2_Human | 0.66233279 |
| 112 | CHD7_19251738_ChIP-ChIP_MESCs_Mouse | 0.66224101 |
| 113 | PU.1_20513432_ChIP-Seq_Bcells_Mouse | 0.64776723 |
| 114 | GATA2_19941826_ChIP-Seq_K562_Human | 0.63874287 |
| 115 | SMAD4_19686287_ChIP-ChIP_HaCaT_Human | 0.63872069 |
| 116 | GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.62833614 |
| 117 | SPI1_20517297_ChIP-Seq_HL60_Human | 0.62268657 |
| 118 | GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.62182689 |
| 119 | GATA1_19941826_ChIP-Seq_K562_Human | 0.62002853 |
| 120 | CJUN_26792858_Chip-Seq_BT549_Human | 0.60027786 |
| 121 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 0.59743177 |
| 122 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 0.56343709 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0009785_altered_susceptibility_to | 4.60015384 |
| 2 | MP0003303_peritoneal_inflammation | 4.09865247 |
| 3 | MP0001835_abnormal_antigen_presentation | 3.94948716 |
| 4 | MP0006082_CNS_inflammation | 3.85539172 |
| 5 | MP0003436_decreased_susceptibility_to | 3.76625580 |
| 6 | MP0003724_increased_susceptibility_to | 3.60261899 |
| 7 | MP0002148_abnormal_hypersensitivity_rea | 3.48513592 |
| 8 | MP0002419_abnormal_innate_immunity | 3.27588549 |
| 9 | MP0005000_abnormal_immune_tolerance | 3.25942017 |
| 10 | MP0004510_myositis | 3.18004124 |
| 11 | MP0005025_abnormal_response_to | 3.12699713 |
| 12 | MP0001790_abnormal_immune_system | 2.80429325 |
| 13 | MP0005387_immune_system_phenotype | 2.80429325 |
| 14 | MP0005058_abnormal_lysosome_morphology | 2.62059910 |
| 15 | MP0002452_abnormal_antigen_presenting | 2.50846864 |
| 16 | MP0004947_skin_inflammation | 2.46484154 |
| 17 | MP0002723_abnormal_immune_serum | 2.43621283 |
| 18 | MP0000685_abnormal_immune_system | 2.42734740 |
| 19 | MP0005671_abnormal_response_to | 2.34627339 |
| 20 | MP0009764_decreased_sensitivity_to | 2.32162968 |
| 21 | MP0001800_abnormal_humoral_immune | 2.31986134 |
| 22 | MP0001533_abnormal_skeleton_physiology | 2.31719752 |
| 23 | MP0004858_abnormal_nervous_system | 2.20629661 |
| 24 | MP0009278_abnormal_bone_marrow | 2.13918918 |
| 25 | MP0003075_altered_response_to | 2.07547219 |
| 26 | MP0001819_abnormal_immune_cell | 2.04138792 |
| 27 | MP0003448_altered_tumor_morphology | 2.00893868 |
| 28 | MP0002139_abnormal_hepatobiliary_system | 1.99522987 |
| 29 | MP0002420_abnormal_adaptive_immunity | 1.98726188 |
| 30 | MP0005464_abnormal_platelet_physiology | 1.97578680 |
| 31 | MP0001845_abnormal_inflammatory_respons | 1.92563901 |
| 32 | MP0000343_altered_response_to | 1.89832724 |
| 33 | MP0001853_heart_inflammation | 1.88339410 |
| 34 | MP0003172_abnormal_lysosome_physiology | 1.86885363 |
| 35 | MP0008469_abnormal_protein_level | 1.84491177 |
| 36 | MP0005167_abnormal_blood-brain_barrier | 1.81333828 |
| 37 | MP0000604_amyloidosis | 1.72531803 |
| 38 | MP0002405_respiratory_system_inflammati | 1.69516189 |
| 39 | MP0002006_tumorigenesis | 1.67138447 |
| 40 | MP0006054_spinal_hemorrhage | 1.65638954 |
| 41 | MP0010155_abnormal_intestine_physiology | 1.65471197 |
| 42 | MP0002998_abnormal_bone_remodeling | 1.57083429 |
| 43 | MP0003195_calcinosis | 1.56779303 |
| 44 | MP0005166_decreased_susceptibility_to | 1.45324421 |
| 45 | MP0009333_abnormal_splenocyte_physiolog | 1.42518665 |
| 46 | MP0005164_abnormal_response_to | 1.41397768 |
| 47 | MP0003186_abnormal_redox_activity | 1.39941385 |
| 48 | MP0001545_abnormal_hematopoietic_system | 1.38292827 |
| 49 | MP0005397_hematopoietic_system_phenotyp | 1.38292827 |
| 50 | MP0000716_abnormal_immune_system | 1.36148893 |
| 51 | MP0000858_altered_metastatic_potential | 1.35294251 |
| 52 | MP0009840_abnormal_foam_cell | 1.31327228 |
| 53 | MP0005310_abnormal_salivary_gland | 1.29661291 |
| 54 | MP0003646_muscle_fatigue | 1.27432441 |
| 55 | MP0001501_abnormal_sleep_pattern | 1.25785467 |
| 56 | MP0008260_abnormal_autophagy | 1.23192214 |
| 57 | MP0002332_abnormal_exercise_endurance | 1.22718385 |
| 58 | MP0002398_abnormal_bone_marrow | 1.21120352 |
| 59 | MP0010307_abnormal_tumor_latency | 1.16296360 |
| 60 | MP0003690_abnormal_glial_cell | 1.15247788 |
| 61 | MP0004782_abnormal_surfactant_physiolog | 1.14281094 |
| 62 | MP0002277_abnormal_respiratory_mucosa | 1.10402163 |
| 63 | MP0001542_abnormal_bone_strength | 1.08082435 |
| 64 | MP0005390_skeleton_phenotype | 1.06075111 |
| 65 | MP0002429_abnormal_blood_cell | 1.04537183 |
| 66 | MP0009763_increased_sensitivity_to | 1.03732225 |
| 67 | MP0005076_abnormal_cell_differentiation | 1.03583656 |
| 68 | MP0003453_abnormal_keratinocyte_physiol | 1.03334565 |
| 69 | MP0003806_abnormal_nucleotide_metabolis | 0.98719945 |
| 70 | MP0003828_pulmonary_edema | 0.98173870 |
| 71 | MP0000689_abnormal_spleen_morphology | 0.97212767 |
| 72 | MP0009765_abnormal_xenobiotic_induced | 0.95358487 |
| 73 | MP0000569_abnormal_digit_pigmentation | 0.95314404 |
| 74 | MP0005165_increased_susceptibility_to | 0.94051504 |
| 75 | MP0003191_abnormal_cellular_cholesterol | 0.91145810 |
| 76 | MP0002722_abnormal_immune_system | 0.87478547 |
| 77 | MP0002933_joint_inflammation | 0.86869748 |
| 78 | MP0010352_gastrointestinal_tract_polyps | 0.84469080 |
| 79 | MP0003300_gastrointestinal_ulcer | 0.84135727 |
| 80 | MP0001663_abnormal_digestive_system | 0.83744933 |
| 81 | MP0005666_abnormal_adipose_tissue | 0.83115952 |
| 82 | MP0005083_abnormal_biliary_tract | 0.82101043 |
| 83 | MP0001851_eye_inflammation | 0.82001328 |
| 84 | MP0005266_abnormal_metabolism | 0.81209350 |
| 85 | MP0003656_abnormal_erythrocyte_physiolo | 0.81151492 |
| 86 | MP0005257_abnormal_intraocular_pressure | 0.80194514 |
| 87 | MP0003091_abnormal_cell_migration | 0.79633946 |
| 88 | MP0002138_abnormal_hepatobiliary_system | 0.77273650 |
| 89 | MP0002254_reproductive_system_inflammat | 0.74677353 |
| 90 | MP0000249_abnormal_blood_vessel | 0.73539127 |
| 91 | MP0003183_abnormal_peptide_metabolism | 0.73289481 |
| 92 | MP0004808_abnormal_hematopoietic_stem | 0.72779461 |
| 93 | MP0003763_abnormal_thymus_physiology | 0.70030777 |
| 94 | MP0008874_decreased_physiological_sensi | 0.68469227 |
| 95 | MP0005647_abnormal_sex_gland | 0.68058229 |
| 96 | MP0008004_abnormal_stomach_pH | 0.67258452 |
| 97 | MP0005023_abnormal_wound_healing | 0.65580045 |
| 98 | MP0000371_diluted_coat_color | 0.64684364 |
| 99 | MP0003795_abnormal_bone_structure | 0.61544371 |
| 100 | MP0005535_abnormal_body_temperature | 0.60578560 |
| 101 | MP0002166_altered_tumor_susceptibility | 0.57519008 |
| 102 | MP0003045_fibrosis | 0.57455973 |
| 103 | MP0003221_abnormal_cardiomyocyte_apopto | 0.56339895 |
| 104 | MP0001764_abnormal_homeostasis | 0.55786677 |
| 105 | MP0002693_abnormal_pancreas_physiology | 0.55743067 |
| 106 | MP0002136_abnormal_kidney_physiology | 0.55630724 |
| 107 | MP0005319_abnormal_enzyme/_coenzyme | 0.55109043 |
| 108 | MP0003566_abnormal_cell_adhesion | 0.54619632 |
| 109 | MP0004883_abnormal_blood_vessel | 0.51966421 |
| 110 | MP0004043_abnormal_pH_regulation | 0.51558353 |
| 111 | MP0008873_increased_physiological_sensi | 0.49111974 |
| 112 | MP0005451_abnormal_body_composition | 0.49081563 |
| 113 | MP0001958_emphysema | 0.48803760 |
| 114 | MP0000920_abnormal_myelination | 0.48405928 |
| 115 | MP0005381_digestive/alimentary_phenotyp | 0.48101756 |
| 116 | MP0003329_amyloid_beta_deposits | 0.47562699 |
| 117 | MP0010386_abnormal_urinary_bladder | 0.47475643 |
| 118 | MP0005376_homeostasis/metabolism_phenot | 0.46361764 |
| 119 | MP0005595_abnormal_vascular_smooth | 0.43569555 |
| 120 | MP0001919_abnormal_reproductive_system | 0.42814962 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Recurrent abscess formation (HP:0002722) | 7.69445618 |
| 2 | Eczematoid dermatitis (HP:0000976) | 7.26434502 |
| 3 | Recurrent bacterial skin infections (HP:0005406) | 6.96377454 |
| 4 | Recurrent gram-negative bacterial infections (HP:0005420) | 6.48656586 |
| 5 | Mediastinal lymphadenopathy (HP:0100721) | 6.08855334 |
| 6 | Stomatitis (HP:0010280) | 6.06941243 |
| 7 | Abnormality of macrophages (HP:0004311) | 5.78372767 |
| 8 | Elevated erythrocyte sedimentation rate (HP:0003565) | 5.45689166 |
| 9 | Autoimmune thrombocytopenia (HP:0001973) | 4.80772396 |
| 10 | Orchitis (HP:0100796) | 4.75144683 |
| 11 | Retrobulbar optic neuritis (HP:0100654) | 4.68042230 |
| 12 | Optic neuritis (HP:0100653) | 4.68042230 |
| 13 | Gingivitis (HP:0000230) | 4.37472069 |
| 14 | Myositis (HP:0100614) | 4.34208158 |
| 15 | Increased cerebral lipofuscin (HP:0011813) | 4.21122384 |
| 16 | Increased IgM level (HP:0003496) | 4.08060590 |
| 17 | Systemic lupus erythematosus (HP:0002725) | 4.02675535 |
| 18 | Recurrent skin infections (HP:0001581) | 4.02465664 |
| 19 | Increased neuronal autofluorescent lipopigment (HP:0002074) | 3.98311569 |
| 20 | Obstructive lung disease (HP:0006536) | 3.94674065 |
| 21 | Chronic obstructive pulmonary disease (HP:0006510) | 3.94674065 |
| 22 | Vasculitis (HP:0002633) | 3.89223691 |
| 23 | Tetraparesis (HP:0002273) | 3.87837598 |
| 24 | Gangrene (HP:0100758) | 3.82232424 |
| 25 | Vacuolated lymphocytes (HP:0001922) | 3.69589753 |
| 26 | Nuclear cataract (HP:0100018) | 3.64560045 |
| 27 | Basal ganglia calcification (HP:0002135) | 3.56042845 |
| 28 | Interstitial pulmonary disease (HP:0006530) | 3.50336677 |
| 29 | Recurrent fungal infections (HP:0002841) | 3.40942050 |
| 30 | Mutism (HP:0002300) | 3.39615123 |
| 31 | Prostate neoplasm (HP:0100787) | 3.25869278 |
| 32 | Recurrent viral infections (HP:0004429) | 3.21360203 |
| 33 | Pulmonary infiltrates (HP:0002113) | 3.19086467 |
| 34 | Thick nail (HP:0001805) | 3.17702535 |
| 35 | Urticaria (HP:0001025) | 3.17361124 |
| 36 | Chronic otitis media (HP:0000389) | 3.07099453 |
| 37 | Axonal loss (HP:0003447) | 3.05382221 |
| 38 | Abnormality of polysaccharide metabolism (HP:0011012) | 3.01848403 |
| 39 | Abnormality of mucopolysaccharide metabolism (HP:0011020) | 3.01848403 |
| 40 | Disinhibition (HP:0000734) | 2.93685878 |
| 41 | Primitive reflexes (palmomental, snout, glabellar) (HP:0002476) | 2.88755526 |
| 42 | Pustule (HP:0200039) | 2.85878464 |
| 43 | Periodontitis (HP:0000704) | 2.84861358 |
| 44 | Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204) | 2.81255261 |
| 45 | Cellulitis (HP:0100658) | 2.80915302 |
| 46 | Premature loss of primary teeth (HP:0006323) | 2.78093616 |
| 47 | Polyneuropathy (HP:0001271) | 2.77921941 |
| 48 | Neurofibrillary tangles (HP:0002185) | 2.72035183 |
| 49 | Hypergammaglobulinemia (HP:0010702) | 2.69062548 |
| 50 | Encephalitis (HP:0002383) | 2.64458082 |
| 51 | Keratoconjunctivitis sicca (HP:0001097) | 2.61736574 |
| 52 | Abnormality of liposaccharide metabolism (HP:0010968) | 2.60191299 |
| 53 | Abnormality of glycosphingolipid metabolism (HP:0004343) | 2.60191299 |
| 54 | Abnormality of glycolipid metabolism (HP:0010969) | 2.60191299 |
| 55 | Leukocytosis (HP:0001974) | 2.58844858 |
| 56 | Glomerulonephritis (HP:0000099) | 2.58648300 |
| 57 | Progressive neurologic deterioration (HP:0002344) | 2.57118414 |
| 58 | Recurrent pneumonia (HP:0006532) | 2.56599399 |
| 59 | Apathy (HP:0000741) | 2.55749471 |
| 60 | Porencephaly (HP:0002132) | 2.54150625 |
| 61 | Arterial thrombosis (HP:0004420) | 2.54096973 |
| 62 | Nausea (HP:0002018) | 2.52464264 |
| 63 | Gastrointestinal infarctions (HP:0005244) | 2.52232645 |
| 64 | Meningitis (HP:0001287) | 2.51475107 |
| 65 | Osteomyelitis (HP:0002754) | 2.47624972 |
| 66 | Myocardial infarction (HP:0001658) | 2.47102406 |
| 67 | Vertigo (HP:0002321) | 2.44977364 |
| 68 | Poor head control (HP:0002421) | 2.44600539 |
| 69 | T lymphocytopenia (HP:0005403) | 2.44261588 |
| 70 | Neoplasm of head and neck (HP:0012288) | 2.43681064 |
| 71 | Esophageal neoplasm (HP:0100751) | 2.43681064 |
| 72 | Diminished motivation (HP:0000745) | 2.41174966 |
| 73 | Hematochezia (HP:0002573) | 2.41001566 |
| 74 | Vertebral compression fractures (HP:0002953) | 2.40824686 |
| 75 | Peritonitis (HP:0002586) | 2.40360872 |
| 76 | Hepatosplenomegaly (HP:0001433) | 2.39453165 |
| 77 | Abnormality of B cell number (HP:0010975) | 2.37665821 |
| 78 | Keratoconjunctivitis (HP:0001096) | 2.37610967 |
| 79 | Keratitis (HP:0000491) | 2.36381679 |
| 80 | Congenital nonbullous ichthyosiform erythroderma (HP:0007479) | 2.34963657 |
| 81 | Bone pain (HP:0002653) | 2.34605979 |
| 82 | Abnormality of T cell number (HP:0011839) | 2.34542253 |
| 83 | Acne (HP:0001061) | 2.33259157 |
| 84 | Abnormality of the pericardium (HP:0001697) | 2.30553987 |
| 85 | Episodic fever (HP:0001954) | 2.30249312 |
| 86 | Inappropriate behavior (HP:0000719) | 2.29185444 |
| 87 | Recurrent lower respiratory tract infections (HP:0002783) | 2.27487726 |
| 88 | Joint swelling (HP:0001386) | 2.27095733 |
| 89 | Recurrent cutaneous fungal infections (HP:0011370) | 2.24191814 |
| 90 | Chronic mucocutaneous candidiasis (HP:0002728) | 2.24191814 |
| 91 | IgA deficiency (HP:0002720) | 2.22920309 |
| 92 | Memory impairment (HP:0002354) | 2.22450474 |
| 93 | Metaphyseal irregularity (HP:0003025) | 2.22401730 |
| 94 | Dysostosis multiplex (HP:0000943) | 2.22394963 |
| 95 | Nephritis (HP:0000123) | 2.22355097 |
| 96 | Gingival bleeding (HP:0000225) | 2.22073853 |
| 97 | B lymphocytopenia (HP:0010976) | 2.21545445 |
| 98 | Increased serum ferritin (HP:0003281) | 2.20745159 |
| 99 | Pulmonary embolism (HP:0002204) | 2.20223705 |
| 100 | Autoimmune hemolytic anemia (HP:0001890) | 2.18035175 |
| 101 | Hemoptysis (HP:0002105) | 2.15889243 |
| 102 | Thin bony cortex (HP:0002753) | 2.15097481 |
| 103 | Nasal polyposis (HP:0100582) | 2.14696314 |
| 104 | Amyloidosis (HP:0011034) | 2.14441150 |
| 105 | Petechiae (HP:0000967) | 2.13457583 |
| 106 | Parakeratosis (HP:0001036) | 2.11925250 |
| 107 | Anorexia (HP:0002039) | 2.11116281 |
| 108 | Abnormality of the pleura (HP:0002103) | 2.07855101 |
| 109 | Glomerulopathy (HP:0100820) | 2.07357797 |
| 110 | Thoracolumbar scoliosis (HP:0002944) | 2.07027160 |
| 111 | Abnormality of the endocardium (HP:0004306) | 2.07019342 |
| 112 | Arthralgia (HP:0002829) | 2.06886973 |
| 113 | Increased IgE level (HP:0003212) | 2.06318967 |
| 114 | Complement deficiency (HP:0004431) | 2.03230130 |
| 115 | Elevated circulating parathyroid hormone (PTH) level (HP:0003165) | 2.00253697 |
| 116 | Hyperparathyroidism (HP:0000843) | 1.96983844 |
| 117 | Neuronal loss in central nervous system (HP:0002529) | 1.96474866 |
| 118 | Loss of speech (HP:0002371) | 1.96448009 |
| 119 | Abnormality of the vasculature of the conjunctiva (HP:0008054) | 1.96284355 |
| 120 | Generalized aminoaciduria (HP:0002909) | 1.95273888 |
| 121 | Cerebral inclusion bodies (HP:0100314) | 1.94635552 |
| 122 | Purpura (HP:0000979) | 1.94362753 |
| 123 | Abnormality of the nasal mucosa (HP:0000433) | 1.94082331 |
| 124 | Lower limb hyperreflexia (HP:0002395) | 1.92094186 |
| 125 | Osteolytic defects of the hand bones (HP:0009699) | 1.89987036 |
| 126 | Osteolytic defects of the phalanges of the hand (HP:0009771) | 1.89987036 |
| 127 | Mucopolysacchariduria (HP:0008155) | 1.89971446 |
| 128 | Urinary glycosaminoglycan excretion (HP:0003541) | 1.89971446 |
| 129 | Pathologic fracture (HP:0002756) | 1.89346730 |
| 130 | Progressive visual loss (HP:0000529) | 1.88423976 |
| 131 | Aseptic necrosis (HP:0010885) | 1.86495057 |
| 132 | Agnosia (HP:0010524) | 1.84644640 |
| 133 | Gastrointestinal stroma tumor (HP:0100723) | 1.83170771 |
| 134 | Abnormality of iron homeostasis (HP:0011031) | 1.82318432 |
| 135 | Asymmetric septal hypertrophy (HP:0001670) | 1.80408978 |
| 136 | Fused cervical vertebrae (HP:0002949) | 1.79954308 |
| 137 | Emphysema (HP:0002097) | 1.79849482 |
| 138 | Skin ulcer (HP:0200042) | 1.78285378 |
| 139 | Abnormality of glycosaminoglycan metabolism (HP:0004371) | 1.78271977 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | PBK | 4.93896631 |
| 2 | RIPK4 | 4.90072595 |
| 3 | MAP3K14 | 4.66430975 |
| 4 | TBK1 | 4.35868849 |
| 5 | IRAK3 | 4.02294296 |
| 6 | BLK | 3.77917384 |
| 7 | IKBKE | 3.37270981 |
| 8 | TYK2 | 3.20439065 |
| 9 | TAOK2 | 3.17803650 |
| 10 | IRAK4 | 3.00934735 |
| 11 | IKBKB | 2.55813817 |
| 12 | JAK3 | 2.41877441 |
| 13 | PRPF4B | 2.29659379 |
| 14 | TXK | 2.24004046 |
| 15 | ERN1 | 1.94870218 |
| 16 | JAK1 | 1.93955868 |
| 17 | KIT | 1.90711096 |
| 18 | FGR | 1.87351420 |
| 19 | MAP3K13 | 1.87253476 |
| 20 | TAOK1 | 1.84765614 |
| 21 | MAP4K1 | 1.82457135 |
| 22 | CSK | 1.68216203 |
| 23 | PIM2 | 1.58951129 |
| 24 | CHUK | 1.57984961 |
| 25 | CDC42BPA | 1.47338162 |
| 26 | MAP3K3 | 1.42718652 |
| 27 | TGFBR2 | 1.42588366 |
| 28 | BMX | 1.31686920 |
| 29 | MST4 | 1.30873734 |
| 30 | RPS6KA4 | 1.29677823 |
| 31 | MATK | 1.29116758 |
| 32 | LATS2 | 1.27970684 |
| 33 | ABL2 | 1.21460970 |
| 34 | SYK | 1.16516335 |
| 35 | BMPR2 | 1.15671519 |
| 36 | MARK3 | 1.13785039 |
| 37 | LYN | 1.13504947 |
| 38 | HCK | 1.13100350 |
| 39 | ZAP70 | 1.09193524 |
| 40 | MST1R | 1.06665782 |
| 41 | EPHB1 | 1.06494013 |
| 42 | TYRO3 | 1.06033522 |
| 43 | ERBB4 | 1.04373827 |
| 44 | MAP3K5 | 1.03180809 |
| 45 | JAK2 | 1.02314908 |
| 46 | LCK | 0.95608572 |
| 47 | EIF2AK2 | 0.93787219 |
| 48 | FES | 0.93037002 |
| 49 | NEK9 | 0.90556792 |
| 50 | CSF1R | 0.88422444 |
| 51 | MAP2K3 | 0.88286447 |
| 52 | NME2 | 0.85704907 |
| 53 | DYRK3 | 0.85171576 |
| 54 | IRAK2 | 0.84381797 |
| 55 | SIK3 | 0.82727602 |
| 56 | PIM1 | 0.82447307 |
| 57 | STK4 | 0.79800767 |
| 58 | ARAF | 0.79622850 |
| 59 | KSR2 | 0.76349196 |
| 60 | HIPK2 | 0.73926508 |
| 61 | IRAK1 | 0.73659176 |
| 62 | YES1 | 0.73400742 |
| 63 | FGFR4 | 0.72182957 |
| 64 | EGFR | 0.71880059 |
| 65 | PRKCD | 0.70071072 |
| 66 | ABL1 | 0.65798041 |
| 67 | RIPK1 | 0.65639954 |
| 68 | FGFR3 | 0.61092477 |
| 69 | BTK | 0.60119824 |
| 70 | CDK6 | 0.58565131 |
| 71 | PDGFRA | 0.58113057 |
| 72 | STK10 | 0.51196541 |
| 73 | SIK2 | 0.51096036 |
| 74 | DAPK3 | 0.49817212 |
| 75 | MAP2K6 | 0.49275536 |
| 76 | MAP3K10 | 0.48867981 |
| 77 | MAP3K1 | 0.46131485 |
| 78 | ACVR1B | 0.45625247 |
| 79 | PRKG2 | 0.45453209 |
| 80 | MAP3K11 | 0.45223555 |
| 81 | STK3 | 0.40717521 |
| 82 | ALK | 0.40547776 |
| 83 | DAPK2 | 0.39019125 |
| 84 | FYN | 0.37829110 |
| 85 | PTK6 | 0.37790703 |
| 86 | EPHA3 | 0.37343508 |
| 87 | GRK7 | 0.37147059 |
| 88 | MOS | 0.34727467 |
| 89 | DDR2 | 0.34431197 |
| 90 | PLK2 | 0.34169915 |
| 91 | CDK4 | 0.32973267 |
| 92 | BMPR1B | 0.32549978 |
| 93 | PDPK1 | 0.32217782 |
| 94 | DYRK1B | 0.30760138 |
| 95 | PRKCQ | 0.30518114 |
| 96 | TAOK3 | 0.28863776 |
| 97 | ERBB3 | 0.28678742 |
| 98 | ICK | 0.27711133 |
| 99 | STK24 | 0.26910194 |
| 100 | CDK14 | 0.26130812 |
| 101 | MAPK7 | 0.25663608 |
| 102 | TEC | 0.23343467 |
| 103 | ADRBK2 | 0.22908075 |
| 104 | LRRK2 | 0.22810685 |
| 105 | TTN | 0.22429140 |
| 106 | CDK15 | 0.22343802 |
| 107 | PDK1 | 0.22176888 |
| 108 | PKN1 | 0.22078603 |
| 109 | INSR | 0.21546614 |
| 110 | CLK1 | 0.21054747 |
| 111 | PDGFRB | 0.20849686 |
| 112 | TESK1 | 0.20702178 |
| 113 | MAPKAPK2 | 0.19567339 |
| 114 | MAPK4 | 0.19007262 |
| 115 | CDK11A | 0.18623473 |
| 116 | CDK18 | 0.18394210 |
| 117 | RPS6KA6 | 0.17886531 |
| 118 | RPS6KA1 | 0.17634762 |
| 119 | SRC | 0.17579110 |
| 120 | GSK3A | 0.16739694 |
| 121 | IGF1R | 0.15560188 |
| 122 | TRPM7 | 0.14735167 |
| 123 | MAP3K9 | 0.14085629 |
| 124 | RPS6KL1 | 0.12473491 |
| 125 | RPS6KC1 | 0.12473491 |
| 126 | TESK2 | 0.11957947 |
| 127 | TLK1 | 0.11314228 |
| 128 | PAK4 | 0.11169353 |
| 129 | SGK1 | 0.10641802 |
| 130 | MAPK3 | 0.10289921 |
| 131 | PRKCZ | 0.09611293 |
| 132 | PRKAA2 | 0.09551986 |
| 133 | MELK | 0.08116029 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Graft-versus-host disease_Homo sapiens_hsa05332 | 3.89085398 |
| 2 | Leishmaniasis_Homo sapiens_hsa05140 | 3.68663850 |
| 3 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 3.12199470 |
| 4 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 2.98493447 |
| 5 | Legionellosis_Homo sapiens_hsa05134 | 2.91736970 |
| 6 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 2.90266022 |
| 7 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 2.81636478 |
| 8 | Allograft rejection_Homo sapiens_hsa05330 | 2.69964373 |
| 9 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 2.68950088 |
| 10 | Malaria_Homo sapiens_hsa05144 | 2.58712531 |
| 11 | Pertussis_Homo sapiens_hsa05133 | 2.54135420 |
| 12 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 2.52764528 |
| 13 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 2.48259909 |
| 14 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 2.44291426 |
| 15 | Asthma_Homo sapiens_hsa05310 | 2.34943708 |
| 16 | Tuberculosis_Homo sapiens_hsa05152 | 2.30094370 |
| 17 | TNF signaling pathway_Homo sapiens_hsa04668 | 2.29841652 |
| 18 | Osteoclast differentiation_Homo sapiens_hsa04380 | 2.26777116 |
| 19 | African trypanosomiasis_Homo sapiens_hsa05143 | 2.17643927 |
| 20 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 2.11195607 |
| 21 | Measles_Homo sapiens_hsa05162 | 2.10283701 |
| 22 | Influenza A_Homo sapiens_hsa05164 | 2.04233323 |
| 23 | Salmonella infection_Homo sapiens_hsa05132 | 1.93149817 |
| 24 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 1.59830195 |
| 25 | Herpes simplex infection_Homo sapiens_hsa05168 | 1.59790884 |
| 26 | Phagosome_Homo sapiens_hsa04145 | 1.53602458 |
| 27 | Toxoplasmosis_Homo sapiens_hsa05145 | 1.48426408 |
| 28 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 1.45069502 |
| 29 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 1.43630741 |
| 30 | Lysosome_Homo sapiens_hsa04142 | 1.42083185 |
| 31 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 1.32982000 |
| 32 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 1.30568434 |
| 33 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 1.21297454 |
| 34 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 1.18955913 |
| 35 | Apoptosis_Homo sapiens_hsa04210 | 1.18486767 |
| 36 | Shigellosis_Homo sapiens_hsa05131 | 1.17542454 |
| 37 | Hepatitis C_Homo sapiens_hsa05160 | 1.12623990 |
| 38 | Amoebiasis_Homo sapiens_hsa05146 | 1.11918730 |
| 39 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 1.10246840 |
| 40 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 1.09732613 |
| 41 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 1.04468979 |
| 42 | Prion diseases_Homo sapiens_hsa05020 | 1.04366516 |
| 43 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 1.03899185 |
| 44 | Hepatitis B_Homo sapiens_hsa05161 | 1.02707541 |
| 45 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 1.02248579 |
| 46 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.98524393 |
| 47 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.98433397 |
| 48 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.85034047 |
| 49 | Viral myocarditis_Homo sapiens_hsa05416 | 0.80305268 |
| 50 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.76740925 |
| 51 | Bladder cancer_Homo sapiens_hsa05219 | 0.75547000 |
| 52 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 0.71917247 |
| 53 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.70101666 |
| 54 | Mineral absorption_Homo sapiens_hsa04978 | 0.69579790 |
| 55 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.68349726 |
| 56 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.64258451 |
| 57 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 0.63301796 |
| 58 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.60380705 |
| 59 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.58679020 |
| 60 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 0.57556163 |
| 61 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.57460988 |
| 62 | Other glycan degradation_Homo sapiens_hsa00511 | 0.54892546 |
| 63 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.54562112 |
| 64 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.52534060 |
| 65 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.52353418 |
| 66 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.51754503 |
| 67 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.51607720 |
| 68 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.49697660 |
| 69 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.48316430 |
| 70 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.47216764 |
| 71 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.46607699 |
| 72 | Complement and coagulation cascades_Homo sapiens_hsa04610 | 0.43881637 |
| 73 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.43592853 |
| 74 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.43463244 |
| 75 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.42868733 |
| 76 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.41713614 |
| 77 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 0.39299897 |
| 78 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.38022188 |
| 79 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.37920446 |
| 80 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.37328106 |
| 81 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.34237382 |
| 82 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.30826590 |
| 83 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.30380858 |
| 84 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.30025084 |
| 85 | Platelet activation_Homo sapiens_hsa04611 | 0.29578493 |
| 86 | Insulin resistance_Homo sapiens_hsa04931 | 0.28786789 |
| 87 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.22954967 |
| 88 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.22714880 |
| 89 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.18572872 |
| 90 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.15884812 |
| 91 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.14435897 |
| 92 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 0.13981829 |
| 93 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.13910628 |
| 94 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.13832562 |
| 95 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.12654547 |
| 96 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.12528037 |
| 97 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.11134301 |
| 98 | PPAR signaling pathway_Homo sapiens_hsa03320 | 0.10842179 |
| 99 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.09940550 |
| 100 | HTLV-I infection_Homo sapiens_hsa05166 | 0.09895109 |
| 101 | Galactose metabolism_Homo sapiens_hsa00052 | 0.09768649 |
| 102 | Proteasome_Homo sapiens_hsa03050 | 0.09204144 |
| 103 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.09098038 |
| 104 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.09086893 |
| 105 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.08338696 |
| 106 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.08333920 |
| 107 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.07475721 |
| 108 | Endocytosis_Homo sapiens_hsa04144 | 0.06822450 |
| 109 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.06498892 |
| 110 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 0.05981789 |
| 111 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.05867948 |
| 112 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.04612298 |
| 113 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.02093251 |

