ACOD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation by symbiont of host defense response (GO:0052509)6.71359704
2modulation by symbiont of host defense response (GO:0052031)6.71359704
3modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.71359704
4modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.71359704
5positive regulation by organism of defense response of other organism involved in symbiotic interact6.71359704
6modulation by symbiont of host immune response (GO:0052553)6.71359704
7response to peptidoglycan (GO:0032494)6.16679427
8positive regulation of chemokine biosynthetic process (GO:0045080)5.85036425
9regulation of cytokine secretion involved in immune response (GO:0002739)5.29453492
10neutrophil activation involved in immune response (GO:0002283)5.03702704
11positive regulation of heat generation (GO:0031652)4.99783509
12positive regulation of interferon-alpha production (GO:0032727)4.98314900
13lipopolysaccharide-mediated signaling pathway (GO:0031663)4.92034258
14regulation of chemokine biosynthetic process (GO:0045073)4.91354679
15regulation of interferon-alpha production (GO:0032647)4.80993437
16macrophage activation involved in immune response (GO:0002281)4.78872371
17regulation of fever generation (GO:0031620)4.78306188
18branching involved in labyrinthine layer morphogenesis (GO:0060670)4.66976766
19hydrogen peroxide biosynthetic process (GO:0050665)4.64152368
20response to host immune response (GO:0052572)4.51832222
21response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.51832222
22positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.37947185
23respiratory burst (GO:0045730)4.34333960
24antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.29045973
25cellular response to type I interferon (GO:0071357)4.21472630
26type I interferon signaling pathway (GO:0060337)4.21472630
27positive regulation of heterotypic cell-cell adhesion (GO:0034116)4.20135098
28response to type I interferon (GO:0034340)4.16807993
29immunoglobulin mediated immune response (GO:0016064)4.14122242
30reactive oxygen species biosynthetic process (GO:1903409)4.09752825
31positive regulation of interleukin-8 biosynthetic process (GO:0045416)4.07314862
32response to defenses of other organism involved in symbiotic interaction (GO:0052173)4.01423139
33response to host (GO:0075136)4.01423139
34response to host defenses (GO:0052200)4.01423139
35negative regulation of viral genome replication (GO:0045071)4.01191172
36response to muramyl dipeptide (GO:0032495)3.99508163
37superoxide anion generation (GO:0042554)3.97826060
38regulation of interferon-beta biosynthetic process (GO:0045357)3.90328713
39regulation of T-helper cell differentiation (GO:0045622)3.88906270
40regulation of immunoglobulin secretion (GO:0051023)3.86582414
41granulocyte activation (GO:0036230)3.86368790
42microglial cell activation (GO:0001774)3.85912337
43positive regulation of cellular amide metabolic process (GO:0034250)3.81871937
44negative regulation of amino acid transport (GO:0051956)3.80753898
45negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.78033072
46regulation of nitric oxide biosynthetic process (GO:0045428)3.77334887
47regulation of podosome assembly (GO:0071801)3.74504800
48regulation of heat generation (GO:0031650)3.74468891
49regulation of interleukin-12 production (GO:0032655)3.72880667
50positive regulation of T-helper cell differentiation (GO:0045624)3.72771174
51regulation of T-helper 1 cell differentiation (GO:0045625)3.72599653
52positive regulation of interferon-beta production (GO:0032728)3.68526740
53response to protozoan (GO:0001562)3.67798996
54detection of molecule of bacterial origin (GO:0032490)3.63394962
55positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.62234738
56regulation of membrane protein ectodomain proteolysis (GO:0051043)3.61648784
57myeloid dendritic cell differentiation (GO:0043011)3.60336712
58natural killer cell mediated cytotoxicity (GO:0042267)3.59501190
59natural killer cell mediated immunity (GO:0002228)3.59501190
60regulation of vitamin D biosynthetic process (GO:0060556)3.57379517
61response to interferon-alpha (GO:0035455)3.56278182
62regulation of mononuclear cell migration (GO:0071675)3.55635563
63NIK/NF-kappaB signaling (GO:0038061)3.53325178
64regulation of type 2 immune response (GO:0002828)3.53297083
65negative regulation of interleukin-12 production (GO:0032695)3.52674339
66negative regulation of nitric oxide biosynthetic process (GO:0045019)3.52228890
67positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.52020449
68regulation of interleukin-8 biosynthetic process (GO:0045414)3.51708612
69positive regulation of toll-like receptor signaling pathway (GO:0034123)3.49260866
70interferon-gamma-mediated signaling pathway (GO:0060333)3.49146118
71positive regulation of acute inflammatory response (GO:0002675)3.48484184
72positive regulation of type 2 immune response (GO:0002830)3.45029717
73neutrophil activation (GO:0042119)3.43061112
74macrophage activation (GO:0042116)3.42179177
75myeloid cell activation involved in immune response (GO:0002275)3.42150309
76negative regulation of growth of symbiont in host (GO:0044130)3.41383259
77negative regulation of growth of symbiont involved in interaction with host (GO:0044146)3.41383259
78modulation of growth of symbiont involved in interaction with host (GO:0044144)3.41383259
79regulation of growth of symbiont in host (GO:0044126)3.41383259
80kynurenine metabolic process (GO:0070189)3.41331977
81germinal center formation (GO:0002467)3.41123710
82regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.40684688
83leukocyte aggregation (GO:0070486)3.39935903
84positive regulation of defense response to virus by host (GO:0002230)3.39154949
85negative regulation of myeloid cell apoptotic process (GO:0033033)3.38333210
86regulation of chronic inflammatory response (GO:0002676)3.37215929
87cellular response to interferon-beta (GO:0035458)3.37162681
88regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.36973032
89defense response to protozoan (GO:0042832)3.35910645
90regulation of heterotypic cell-cell adhesion (GO:0034114)3.35627514
91positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.35108037
92regulation of type I interferon-mediated signaling pathway (GO:0060338)3.35090789
93regulation of dendritic cell antigen processing and presentation (GO:0002604)3.34679416
94positive regulation of gamma-delta T cell activation (GO:0046645)3.34596225
95cellular response to nicotine (GO:0071316)3.34389617
96positive regulation of cAMP-mediated signaling (GO:0043950)3.32466177
97regulation of interferon-gamma biosynthetic process (GO:0045072)3.31261357
98T-helper 1 type immune response (GO:0042088)3.30106030
99positive regulation of NF-kappaB import into nucleus (GO:0042346)3.29679048
100positive regulation of chemokine production (GO:0032722)3.29030264
101positive regulation of antigen processing and presentation (GO:0002579)3.28429636
102regulation of NF-kappaB import into nucleus (GO:0042345)3.28291499
103positive regulation of natural killer cell differentiation (GO:0032825)3.27917934
104regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.27481001
105low-density lipoprotein particle clearance (GO:0034383)3.27224958
106cellular response to interferon-alpha (GO:0035457)3.26796306
107regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.25427419
108lymphocyte chemotaxis (GO:0048247)3.23937923
109regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.23780527
110tryptophan catabolic process (GO:0006569)3.23507514
111indole-containing compound catabolic process (GO:0042436)3.23507514
112indolalkylamine catabolic process (GO:0046218)3.23507514
113positive regulation of nitric oxide biosynthetic process (GO:0045429)3.23296850
114positive regulation of mast cell activation involved in immune response (GO:0033008)3.23025562
115positive regulation of mast cell degranulation (GO:0043306)3.23025562
116antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.22768197
117antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.22768197
118interferon-gamma secretion (GO:0072643)3.22013581
119regulation of T cell tolerance induction (GO:0002664)3.21869233
120positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.21175115
121regulation of antigen processing and presentation (GO:0002577)3.20501392
122regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.19444268
123activation of MAPKKK activity (GO:0000185)3.17421229
124regulation of vitamin metabolic process (GO:0030656)3.15154546
125cellular response to virus (GO:0098586)3.15114928
126negative regulation of interleukin-17 production (GO:0032700)3.14518433
127positive regulation of interleukin-6 production (GO:0032755)3.14174539
128I-kappaB phosphorylation (GO:0007252)3.13500148
129regulation of T-helper 2 cell differentiation (GO:0045628)3.12935644
130cellular response to exogenous dsRNA (GO:0071360)3.12255855
131regulation of T-helper 1 type immune response (GO:0002825)3.11506589
132response to interferon-beta (GO:0035456)3.11463893
133dendritic cell differentiation (GO:0097028)3.10879642
134negative regulation of inflammatory response to antigenic stimulus (GO:0002862)3.10529429
135cellular response to lipopolysaccharide (GO:0071222)3.10009689
136positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.09498388
137positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.09256200
138cellular response to molecule of bacterial origin (GO:0071219)3.08929118
139regulation of inflammatory response to antigenic stimulus (GO:0002861)3.08749989
140eosinophil chemotaxis (GO:0048245)3.08252722
141positive regulation of interleukin-12 production (GO:0032735)3.07860350
142positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.05870255
143monocyte chemotaxis (GO:0002548)3.05279320
144T cell migration (GO:0072678)3.05199938
145B cell mediated immunity (GO:0019724)3.04095962
146negative regulation of lipid storage (GO:0010888)3.04094586
147negative regulation of cytokine production involved in immune response (GO:0002719)3.03733228
148regulation of RIG-I signaling pathway (GO:0039535)3.02477771
149myeloid dendritic cell activation (GO:0001773)3.02035132
150negative regulation of production of molecular mediator of immune response (GO:0002701)3.00150443

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse7.84445588
2IRF8_22096565_ChIP-ChIP_GC-B_Human7.76373581
3BP1_19119308_ChIP-ChIP_Hs578T_Human6.80145065
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human5.60655831
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.68140335
6IRF8_27001747_Chip-Seq_BMDM_Mouse4.56479802
7SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse4.11377212
8Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.83406695
9NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.81053833
10RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.75661694
11MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.94737368
12EGR1_19374776_ChIP-ChIP_THP-1_Human2.91284618
13MYB_21317192_ChIP-Seq_ERMYB_Mouse2.81349917
14FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.68980375
15STAT4_19710469_ChIP-ChIP_TH1__Mouse2.64854138
16STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.57620380
17SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.55430676
18STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.51128737
19NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.14759484
20NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.05082437
21STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.01855156
22PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.90911116
23BRD4_27068464_Chip-Seq_AML-cells_Mouse1.86449258
24SPI1_23547873_ChIP-Seq_NB4_Human1.81565069
25CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.71928393
26THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.69524796
27CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.66002688
28GATA1_22025678_ChIP-Seq_K562_Human1.64086117
29VDR_24787735_ChIP-Seq_THP-1_Human1.60657979
30PU_27001747_Chip-Seq_BMDM_Mouse1.59124439
31STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.57162608
32ESR2_21235772_ChIP-Seq_MCF-7_Human1.56442233
33KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.51478025
34KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.51478025
35KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.51478025
36PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.48006398
37VDR_24763502_ChIP-Seq_THP-1_Human1.46254497
38SMAD_19615063_ChIP-ChIP_OVARY_Human1.45018302
39SPI1_23127762_ChIP-Seq_K562_Human1.37944915
40CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.35979846
41TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.35183879
42RUNX1_22412390_ChIP-Seq_EML_Mouse1.32812757
43MYB_26560356_Chip-Seq_TH2_Human1.30808543
44ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.27793421
45TP63_17297297_ChIP-ChIP_HaCaT_Human1.27579445
46CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.27553241
47VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.27471966
48ESR1_21235772_ChIP-Seq_MCF-7_Human1.27163027
49RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.25170258
50MAF_26560356_Chip-Seq_TH1_Human1.20496673
51RUNX_20019798_ChIP-Seq_JUKART_Human1.19497112
52KDM2B_26808549_Chip-Seq_SUP-B15_Human1.17610226
53PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.16178036
54NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.15978935
55TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.13362575
56CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.12685560
57VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.12310999
58GATA3_26560356_Chip-Seq_TH2_Human1.11315285
59SCL_19346495_ChIP-Seq_HPC-7_Human1.10348765
60IKZF1_21737484_ChIP-ChIP_HCT116_Human1.10138894
61SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.10045605
62TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.10041946
63GATA2_21666600_ChIP-Seq_HMVEC_Human1.09651040
64PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.07530007
65FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.04849160
66EGR1_19032775_ChIP-ChIP_M12_Human1.04260753
67STAT1_20625510_ChIP-Seq_HELA_Human1.03552979
68CDX2_19796622_ChIP-Seq_MESCs_Mouse1.02594374
69NRF2_20460467_ChIP-Seq_MEFs_Mouse1.02472215
70NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.02472215
71MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.02104180
72TRIM28_21343339_ChIP-Seq_HEK293_Human1.01278510
73MYB_26560356_Chip-Seq_TH1_Human1.00157354
74GATA3_27048872_Chip-Seq_THYMUS_Human0.98066173
75TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.95415095
76GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94878241
77SOX2_20726797_ChIP-Seq_SW620_Human0.94815685
78LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.93519826
79GATA2_22383799_ChIP-Seq_G1ME_Mouse0.92496675
80GATA1_19941827_ChIP-Seq_MEL_Mouse0.92176758
81KDM2B_26808549_Chip-Seq_DND41_Human0.89003231
82FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.86256112
83E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.85808407
84TCF7_22412390_ChIP-Seq_EML_Mouse0.83545575
85CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.82427969
86JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.79826066
87TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.78250923
88GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.78134918
89STAT3_1855785_ChIP-Seq_MESCs_Mouse0.77953502
90UTX_26944678_Chip-Seq_JUKART_Human0.77912257
91VDR_21846776_ChIP-Seq_THP-1_Human0.75533856
92SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.75273683
93ELK3_25401928_ChIP-Seq_HUVEC_Human0.74969973
94CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.74935483
95BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.72675437
96JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.72581527
97LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.72485831
98KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.71842539
99LXR_22292898_ChIP-Seq_THP-1_Human0.69930090
100EGR1_23403033_ChIP-Seq_LIVER_Mouse0.68774374
101FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.68493782
102RXR_22158963_ChIP-Seq_LIVER_Mouse0.68027384
103KDM2B_26808549_Chip-Seq_K562_Human0.67449011
104SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.66971600
105TFEB_21752829_ChIP-Seq_HELA_Human0.66871543
106LXR_22158963_ChIP-Seq_LIVER_Mouse0.66825669
107SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.66593612
108SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.66593612
109ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.66320956
110GATA1_19941827_ChIP-Seq_MEL86_Mouse0.66278521
111MAF_26560356_Chip-Seq_TH2_Human0.66233279
112CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.66224101
113PU.1_20513432_ChIP-Seq_Bcells_Mouse0.64776723
114GATA2_19941826_ChIP-Seq_K562_Human0.63874287
115SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.63872069
116GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.62833614
117SPI1_20517297_ChIP-Seq_HL60_Human0.62268657
118GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.62182689
119GATA1_19941826_ChIP-Seq_K562_Human0.62002853
120CJUN_26792858_Chip-Seq_BT549_Human0.60027786
121MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.59743177
122RARG_19884340_ChIP-ChIP_MEFs_Mouse0.56343709

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009785_altered_susceptibility_to4.60015384
2MP0003303_peritoneal_inflammation4.09865247
3MP0001835_abnormal_antigen_presentation3.94948716
4MP0006082_CNS_inflammation3.85539172
5MP0003436_decreased_susceptibility_to3.76625580
6MP0003724_increased_susceptibility_to3.60261899
7MP0002148_abnormal_hypersensitivity_rea3.48513592
8MP0002419_abnormal_innate_immunity3.27588549
9MP0005000_abnormal_immune_tolerance3.25942017
10MP0004510_myositis3.18004124
11MP0005025_abnormal_response_to3.12699713
12MP0001790_abnormal_immune_system2.80429325
13MP0005387_immune_system_phenotype2.80429325
14MP0005058_abnormal_lysosome_morphology2.62059910
15MP0002452_abnormal_antigen_presenting2.50846864
16MP0004947_skin_inflammation2.46484154
17MP0002723_abnormal_immune_serum2.43621283
18MP0000685_abnormal_immune_system2.42734740
19MP0005671_abnormal_response_to2.34627339
20MP0009764_decreased_sensitivity_to2.32162968
21MP0001800_abnormal_humoral_immune2.31986134
22MP0001533_abnormal_skeleton_physiology2.31719752
23MP0004858_abnormal_nervous_system2.20629661
24MP0009278_abnormal_bone_marrow2.13918918
25MP0003075_altered_response_to2.07547219
26MP0001819_abnormal_immune_cell2.04138792
27MP0003448_altered_tumor_morphology2.00893868
28MP0002139_abnormal_hepatobiliary_system1.99522987
29MP0002420_abnormal_adaptive_immunity1.98726188
30MP0005464_abnormal_platelet_physiology1.97578680
31MP0001845_abnormal_inflammatory_respons1.92563901
32MP0000343_altered_response_to1.89832724
33MP0001853_heart_inflammation1.88339410
34MP0003172_abnormal_lysosome_physiology1.86885363
35MP0008469_abnormal_protein_level1.84491177
36MP0005167_abnormal_blood-brain_barrier1.81333828
37MP0000604_amyloidosis1.72531803
38MP0002405_respiratory_system_inflammati1.69516189
39MP0002006_tumorigenesis1.67138447
40MP0006054_spinal_hemorrhage1.65638954
41MP0010155_abnormal_intestine_physiology1.65471197
42MP0002998_abnormal_bone_remodeling1.57083429
43MP0003195_calcinosis1.56779303
44MP0005166_decreased_susceptibility_to1.45324421
45MP0009333_abnormal_splenocyte_physiolog1.42518665
46MP0005164_abnormal_response_to1.41397768
47MP0003186_abnormal_redox_activity1.39941385
48MP0001545_abnormal_hematopoietic_system1.38292827
49MP0005397_hematopoietic_system_phenotyp1.38292827
50MP0000716_abnormal_immune_system1.36148893
51MP0000858_altered_metastatic_potential1.35294251
52MP0009840_abnormal_foam_cell1.31327228
53MP0005310_abnormal_salivary_gland1.29661291
54MP0003646_muscle_fatigue1.27432441
55MP0001501_abnormal_sleep_pattern1.25785467
56MP0008260_abnormal_autophagy1.23192214
57MP0002332_abnormal_exercise_endurance1.22718385
58MP0002398_abnormal_bone_marrow1.21120352
59MP0010307_abnormal_tumor_latency1.16296360
60MP0003690_abnormal_glial_cell1.15247788
61MP0004782_abnormal_surfactant_physiolog1.14281094
62MP0002277_abnormal_respiratory_mucosa1.10402163
63MP0001542_abnormal_bone_strength1.08082435
64MP0005390_skeleton_phenotype1.06075111
65MP0002429_abnormal_blood_cell1.04537183
66MP0009763_increased_sensitivity_to1.03732225
67MP0005076_abnormal_cell_differentiation1.03583656
68MP0003453_abnormal_keratinocyte_physiol1.03334565
69MP0003806_abnormal_nucleotide_metabolis0.98719945
70MP0003828_pulmonary_edema0.98173870
71MP0000689_abnormal_spleen_morphology0.97212767
72MP0009765_abnormal_xenobiotic_induced0.95358487
73MP0000569_abnormal_digit_pigmentation0.95314404
74MP0005165_increased_susceptibility_to0.94051504
75MP0003191_abnormal_cellular_cholesterol0.91145810
76MP0002722_abnormal_immune_system0.87478547
77MP0002933_joint_inflammation0.86869748
78MP0010352_gastrointestinal_tract_polyps0.84469080
79MP0003300_gastrointestinal_ulcer0.84135727
80MP0001663_abnormal_digestive_system0.83744933
81MP0005666_abnormal_adipose_tissue0.83115952
82MP0005083_abnormal_biliary_tract0.82101043
83MP0001851_eye_inflammation0.82001328
84MP0005266_abnormal_metabolism0.81209350
85MP0003656_abnormal_erythrocyte_physiolo0.81151492
86MP0005257_abnormal_intraocular_pressure0.80194514
87MP0003091_abnormal_cell_migration0.79633946
88MP0002138_abnormal_hepatobiliary_system0.77273650
89MP0002254_reproductive_system_inflammat0.74677353
90MP0000249_abnormal_blood_vessel0.73539127
91MP0003183_abnormal_peptide_metabolism0.73289481
92MP0004808_abnormal_hematopoietic_stem0.72779461
93MP0003763_abnormal_thymus_physiology0.70030777
94MP0008874_decreased_physiological_sensi0.68469227
95MP0005647_abnormal_sex_gland0.68058229
96MP0008004_abnormal_stomach_pH0.67258452
97MP0005023_abnormal_wound_healing0.65580045
98MP0000371_diluted_coat_color0.64684364
99MP0003795_abnormal_bone_structure0.61544371
100MP0005535_abnormal_body_temperature0.60578560
101MP0002166_altered_tumor_susceptibility0.57519008
102MP0003045_fibrosis0.57455973
103MP0003221_abnormal_cardiomyocyte_apopto0.56339895
104MP0001764_abnormal_homeostasis0.55786677
105MP0002693_abnormal_pancreas_physiology0.55743067
106MP0002136_abnormal_kidney_physiology0.55630724
107MP0005319_abnormal_enzyme/_coenzyme0.55109043
108MP0003566_abnormal_cell_adhesion0.54619632
109MP0004883_abnormal_blood_vessel0.51966421
110MP0004043_abnormal_pH_regulation0.51558353
111MP0008873_increased_physiological_sensi0.49111974
112MP0005451_abnormal_body_composition0.49081563
113MP0001958_emphysema0.48803760
114MP0000920_abnormal_myelination0.48405928
115MP0005381_digestive/alimentary_phenotyp0.48101756
116MP0003329_amyloid_beta_deposits0.47562699
117MP0010386_abnormal_urinary_bladder0.47475643
118MP0005376_homeostasis/metabolism_phenot0.46361764
119MP0005595_abnormal_vascular_smooth0.43569555
120MP0001919_abnormal_reproductive_system0.42814962

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)7.69445618
2Eczematoid dermatitis (HP:0000976)7.26434502
3Recurrent bacterial skin infections (HP:0005406)6.96377454
4Recurrent gram-negative bacterial infections (HP:0005420)6.48656586
5Mediastinal lymphadenopathy (HP:0100721)6.08855334
6Stomatitis (HP:0010280)6.06941243
7Abnormality of macrophages (HP:0004311)5.78372767
8Elevated erythrocyte sedimentation rate (HP:0003565)5.45689166
9Autoimmune thrombocytopenia (HP:0001973)4.80772396
10Orchitis (HP:0100796)4.75144683
11Retrobulbar optic neuritis (HP:0100654)4.68042230
12Optic neuritis (HP:0100653)4.68042230
13Gingivitis (HP:0000230)4.37472069
14Myositis (HP:0100614)4.34208158
15Increased cerebral lipofuscin (HP:0011813)4.21122384
16Increased IgM level (HP:0003496)4.08060590
17Systemic lupus erythematosus (HP:0002725)4.02675535
18Recurrent skin infections (HP:0001581)4.02465664
19Increased neuronal autofluorescent lipopigment (HP:0002074)3.98311569
20Obstructive lung disease (HP:0006536)3.94674065
21Chronic obstructive pulmonary disease (HP:0006510)3.94674065
22Vasculitis (HP:0002633)3.89223691
23Tetraparesis (HP:0002273)3.87837598
24Gangrene (HP:0100758)3.82232424
25Vacuolated lymphocytes (HP:0001922)3.69589753
26Nuclear cataract (HP:0100018)3.64560045
27Basal ganglia calcification (HP:0002135)3.56042845
28Interstitial pulmonary disease (HP:0006530)3.50336677
29Recurrent fungal infections (HP:0002841)3.40942050
30Mutism (HP:0002300)3.39615123
31Prostate neoplasm (HP:0100787)3.25869278
32Recurrent viral infections (HP:0004429)3.21360203
33Pulmonary infiltrates (HP:0002113)3.19086467
34Thick nail (HP:0001805)3.17702535
35Urticaria (HP:0001025)3.17361124
36Chronic otitis media (HP:0000389)3.07099453
37Axonal loss (HP:0003447)3.05382221
38Abnormality of polysaccharide metabolism (HP:0011012)3.01848403
39Abnormality of mucopolysaccharide metabolism (HP:0011020)3.01848403
40Disinhibition (HP:0000734)2.93685878
41Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.88755526
42Pustule (HP:0200039)2.85878464
43Periodontitis (HP:0000704)2.84861358
44Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.81255261
45Cellulitis (HP:0100658)2.80915302
46Premature loss of primary teeth (HP:0006323)2.78093616
47Polyneuropathy (HP:0001271)2.77921941
48Neurofibrillary tangles (HP:0002185)2.72035183
49Hypergammaglobulinemia (HP:0010702)2.69062548
50Encephalitis (HP:0002383)2.64458082
51Keratoconjunctivitis sicca (HP:0001097)2.61736574
52Abnormality of liposaccharide metabolism (HP:0010968)2.60191299
53Abnormality of glycosphingolipid metabolism (HP:0004343)2.60191299
54Abnormality of glycolipid metabolism (HP:0010969)2.60191299
55Leukocytosis (HP:0001974)2.58844858
56Glomerulonephritis (HP:0000099)2.58648300
57Progressive neurologic deterioration (HP:0002344)2.57118414
58Recurrent pneumonia (HP:0006532)2.56599399
59Apathy (HP:0000741)2.55749471
60Porencephaly (HP:0002132)2.54150625
61Arterial thrombosis (HP:0004420)2.54096973
62Nausea (HP:0002018)2.52464264
63Gastrointestinal infarctions (HP:0005244)2.52232645
64Meningitis (HP:0001287)2.51475107
65Osteomyelitis (HP:0002754)2.47624972
66Myocardial infarction (HP:0001658)2.47102406
67Vertigo (HP:0002321)2.44977364
68Poor head control (HP:0002421)2.44600539
69T lymphocytopenia (HP:0005403)2.44261588
70Neoplasm of head and neck (HP:0012288)2.43681064
71Esophageal neoplasm (HP:0100751)2.43681064
72Diminished motivation (HP:0000745)2.41174966
73Hematochezia (HP:0002573)2.41001566
74Vertebral compression fractures (HP:0002953)2.40824686
75Peritonitis (HP:0002586)2.40360872
76Hepatosplenomegaly (HP:0001433)2.39453165
77Abnormality of B cell number (HP:0010975)2.37665821
78Keratoconjunctivitis (HP:0001096)2.37610967
79Keratitis (HP:0000491)2.36381679
80Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.34963657
81Bone pain (HP:0002653)2.34605979
82Abnormality of T cell number (HP:0011839)2.34542253
83Acne (HP:0001061)2.33259157
84Abnormality of the pericardium (HP:0001697)2.30553987
85Episodic fever (HP:0001954)2.30249312
86Inappropriate behavior (HP:0000719)2.29185444
87Recurrent lower respiratory tract infections (HP:0002783)2.27487726
88Joint swelling (HP:0001386)2.27095733
89Recurrent cutaneous fungal infections (HP:0011370)2.24191814
90Chronic mucocutaneous candidiasis (HP:0002728)2.24191814
91IgA deficiency (HP:0002720)2.22920309
92Memory impairment (HP:0002354)2.22450474
93Metaphyseal irregularity (HP:0003025)2.22401730
94Dysostosis multiplex (HP:0000943)2.22394963
95Nephritis (HP:0000123)2.22355097
96Gingival bleeding (HP:0000225)2.22073853
97B lymphocytopenia (HP:0010976)2.21545445
98Increased serum ferritin (HP:0003281)2.20745159
99Pulmonary embolism (HP:0002204)2.20223705
100Autoimmune hemolytic anemia (HP:0001890)2.18035175
101Hemoptysis (HP:0002105)2.15889243
102Thin bony cortex (HP:0002753)2.15097481
103Nasal polyposis (HP:0100582)2.14696314
104Amyloidosis (HP:0011034)2.14441150
105Petechiae (HP:0000967)2.13457583
106Parakeratosis (HP:0001036)2.11925250
107Anorexia (HP:0002039)2.11116281
108Abnormality of the pleura (HP:0002103)2.07855101
109Glomerulopathy (HP:0100820)2.07357797
110Thoracolumbar scoliosis (HP:0002944)2.07027160
111Abnormality of the endocardium (HP:0004306)2.07019342
112Arthralgia (HP:0002829)2.06886973
113Increased IgE level (HP:0003212)2.06318967
114Complement deficiency (HP:0004431)2.03230130
115Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.00253697
116Hyperparathyroidism (HP:0000843)1.96983844
117Neuronal loss in central nervous system (HP:0002529)1.96474866
118Loss of speech (HP:0002371)1.96448009
119Abnormality of the vasculature of the conjunctiva (HP:0008054)1.96284355
120Generalized aminoaciduria (HP:0002909)1.95273888
121Cerebral inclusion bodies (HP:0100314)1.94635552
122Purpura (HP:0000979)1.94362753
123Abnormality of the nasal mucosa (HP:0000433)1.94082331
124Lower limb hyperreflexia (HP:0002395)1.92094186
125Osteolytic defects of the hand bones (HP:0009699)1.89987036
126Osteolytic defects of the phalanges of the hand (HP:0009771)1.89987036
127Mucopolysacchariduria (HP:0008155)1.89971446
128Urinary glycosaminoglycan excretion (HP:0003541)1.89971446
129Pathologic fracture (HP:0002756)1.89346730
130Progressive visual loss (HP:0000529)1.88423976
131Aseptic necrosis (HP:0010885)1.86495057
132Agnosia (HP:0010524)1.84644640
133Gastrointestinal stroma tumor (HP:0100723)1.83170771
134Abnormality of iron homeostasis (HP:0011031)1.82318432
135Asymmetric septal hypertrophy (HP:0001670)1.80408978
136Fused cervical vertebrae (HP:0002949)1.79954308
137Emphysema (HP:0002097)1.79849482
138Skin ulcer (HP:0200042)1.78285378
139Abnormality of glycosaminoglycan metabolism (HP:0004371)1.78271977

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PBK4.93896631
2RIPK44.90072595
3MAP3K144.66430975
4TBK14.35868849
5IRAK34.02294296
6BLK3.77917384
7IKBKE3.37270981
8TYK23.20439065
9TAOK23.17803650
10IRAK43.00934735
11IKBKB2.55813817
12JAK32.41877441
13PRPF4B2.29659379
14TXK2.24004046
15ERN11.94870218
16JAK11.93955868
17KIT1.90711096
18FGR1.87351420
19MAP3K131.87253476
20TAOK11.84765614
21MAP4K11.82457135
22CSK1.68216203
23PIM21.58951129
24CHUK1.57984961
25CDC42BPA1.47338162
26MAP3K31.42718652
27TGFBR21.42588366
28BMX1.31686920
29MST41.30873734
30RPS6KA41.29677823
31MATK1.29116758
32LATS21.27970684
33ABL21.21460970
34SYK1.16516335
35BMPR21.15671519
36MARK31.13785039
37LYN1.13504947
38HCK1.13100350
39ZAP701.09193524
40MST1R1.06665782
41EPHB11.06494013
42TYRO31.06033522
43ERBB41.04373827
44MAP3K51.03180809
45JAK21.02314908
46LCK0.95608572
47EIF2AK20.93787219
48FES0.93037002
49NEK90.90556792
50CSF1R0.88422444
51MAP2K30.88286447
52NME20.85704907
53DYRK30.85171576
54IRAK20.84381797
55SIK30.82727602
56PIM10.82447307
57STK40.79800767
58ARAF0.79622850
59KSR20.76349196
60HIPK20.73926508
61IRAK10.73659176
62YES10.73400742
63FGFR40.72182957
64EGFR0.71880059
65PRKCD0.70071072
66ABL10.65798041
67RIPK10.65639954
68FGFR30.61092477
69BTK0.60119824
70CDK60.58565131
71PDGFRA0.58113057
72STK100.51196541
73SIK20.51096036
74DAPK30.49817212
75MAP2K60.49275536
76MAP3K100.48867981
77MAP3K10.46131485
78ACVR1B0.45625247
79PRKG20.45453209
80MAP3K110.45223555
81STK30.40717521
82ALK0.40547776
83DAPK20.39019125
84FYN0.37829110
85PTK60.37790703
86EPHA30.37343508
87GRK70.37147059
88MOS0.34727467
89DDR20.34431197
90PLK20.34169915
91CDK40.32973267
92BMPR1B0.32549978
93PDPK10.32217782
94DYRK1B0.30760138
95PRKCQ0.30518114
96TAOK30.28863776
97ERBB30.28678742
98ICK0.27711133
99STK240.26910194
100CDK140.26130812
101MAPK70.25663608
102TEC0.23343467
103ADRBK20.22908075
104LRRK20.22810685
105TTN0.22429140
106CDK150.22343802
107PDK10.22176888
108PKN10.22078603
109INSR0.21546614
110CLK10.21054747
111PDGFRB0.20849686
112TESK10.20702178
113MAPKAPK20.19567339
114MAPK40.19007262
115CDK11A0.18623473
116CDK180.18394210
117RPS6KA60.17886531
118RPS6KA10.17634762
119SRC0.17579110
120GSK3A0.16739694
121IGF1R0.15560188
122TRPM70.14735167
123MAP3K90.14085629
124RPS6KL10.12473491
125RPS6KC10.12473491
126TESK20.11957947
127TLK10.11314228
128PAK40.11169353
129SGK10.10641802
130MAPK30.10289921
131PRKCZ0.09611293
132PRKAA20.09551986
133MELK0.08116029

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053323.89085398
2Leishmaniasis_Homo sapiens_hsa051403.68663850
3Toll-like receptor signaling pathway_Homo sapiens_hsa046203.12199470
4Staphylococcus aureus infection_Homo sapiens_hsa051502.98493447
5Legionellosis_Homo sapiens_hsa051342.91736970
6Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.90266022
7NOD-like receptor signaling pathway_Homo sapiens_hsa046212.81636478
8Allograft rejection_Homo sapiens_hsa053302.69964373
9NF-kappa B signaling pathway_Homo sapiens_hsa040642.68950088
10Malaria_Homo sapiens_hsa051442.58712531
11Pertussis_Homo sapiens_hsa051332.54135420
12RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.52764528
13Type I diabetes mellitus_Homo sapiens_hsa049402.48259909
14Rheumatoid arthritis_Homo sapiens_hsa053232.44291426
15Asthma_Homo sapiens_hsa053102.34943708
16Tuberculosis_Homo sapiens_hsa051522.30094370
17TNF signaling pathway_Homo sapiens_hsa046682.29841652
18Osteoclast differentiation_Homo sapiens_hsa043802.26777116
19African trypanosomiasis_Homo sapiens_hsa051432.17643927
20Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.11195607
21Measles_Homo sapiens_hsa051622.10283701
22Influenza A_Homo sapiens_hsa051642.04233323
23Salmonella infection_Homo sapiens_hsa051321.93149817
24Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.59830195
25Herpes simplex infection_Homo sapiens_hsa051681.59790884
26Phagosome_Homo sapiens_hsa041451.53602458
27Toxoplasmosis_Homo sapiens_hsa051451.48426408
28Hematopoietic cell lineage_Homo sapiens_hsa046401.45069502
29Intestinal immune network for IgA production_Homo sapiens_hsa046721.43630741
30Lysosome_Homo sapiens_hsa041421.42083185
31Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.32982000
32B cell receptor signaling pathway_Homo sapiens_hsa046621.30568434
33Chemokine signaling pathway_Homo sapiens_hsa040621.21297454
34Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.18955913
35Apoptosis_Homo sapiens_hsa042101.18486767
36Shigellosis_Homo sapiens_hsa051311.17542454
37Hepatitis C_Homo sapiens_hsa051601.12623990
38Amoebiasis_Homo sapiens_hsa051461.11918730
39Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.10246840
40Jak-STAT signaling pathway_Homo sapiens_hsa046301.09732613
41Autoimmune thyroid disease_Homo sapiens_hsa053201.04468979
42Prion diseases_Homo sapiens_hsa050201.04366516
43Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.03899185
44Hepatitis B_Homo sapiens_hsa051611.02707541
45AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.02248579
46Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.98524393
47Antigen processing and presentation_Homo sapiens_hsa046120.98433397
48Adipocytokine signaling pathway_Homo sapiens_hsa049200.85034047
49Viral myocarditis_Homo sapiens_hsa054160.80305268
50Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.76740925
51Bladder cancer_Homo sapiens_hsa052190.75547000
52Glycosaminoglycan degradation_Homo sapiens_hsa005310.71917247
53Type II diabetes mellitus_Homo sapiens_hsa049300.70101666
54Mineral absorption_Homo sapiens_hsa049780.69579790
55Collecting duct acid secretion_Homo sapiens_hsa049660.68349726
56Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.64258451
57T cell receptor signaling pathway_Homo sapiens_hsa046600.63301796
58Tryptophan metabolism_Homo sapiens_hsa003800.60380705
59Neurotrophin signaling pathway_Homo sapiens_hsa047220.58679020
60Leukocyte transendothelial migration_Homo sapiens_hsa046700.57556163
61Prolactin signaling pathway_Homo sapiens_hsa049170.57460988
62Other glycan degradation_Homo sapiens_hsa005110.54892546
63Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.54562112
64Sulfur metabolism_Homo sapiens_hsa009200.52534060
65Acute myeloid leukemia_Homo sapiens_hsa052210.52353418
66HIF-1 signaling pathway_Homo sapiens_hsa040660.51754503
67Primary immunodeficiency_Homo sapiens_hsa053400.51607720
68Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.49697660
69Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.48316430
70Epstein-Barr virus infection_Homo sapiens_hsa051690.47216764
71SNARE interactions in vesicular transport_Homo sapiens_hsa041300.46607699
72Complement and coagulation cascades_Homo sapiens_hsa046100.43881637
73Sphingolipid signaling pathway_Homo sapiens_hsa040710.43592853
74Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.43463244
75Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.42868733
76Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.41713614
77Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.39299897
78Folate biosynthesis_Homo sapiens_hsa007900.38022188
79Small cell lung cancer_Homo sapiens_hsa052220.37920446
80Chronic myeloid leukemia_Homo sapiens_hsa052200.37328106
81Systemic lupus erythematosus_Homo sapiens_hsa053220.34237382
82VEGF signaling pathway_Homo sapiens_hsa043700.30826590
83Pancreatic cancer_Homo sapiens_hsa052120.30380858
84Dorso-ventral axis formation_Homo sapiens_hsa043200.30025084
85Platelet activation_Homo sapiens_hsa046110.29578493
86Insulin resistance_Homo sapiens_hsa049310.28786789
87Viral carcinogenesis_Homo sapiens_hsa052030.22954967
88Caffeine metabolism_Homo sapiens_hsa002320.22714880
89Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.18572872
90Arginine biosynthesis_Homo sapiens_hsa002200.15884812
91Carbohydrate digestion and absorption_Homo sapiens_hsa049730.14435897
92Proteoglycans in cancer_Homo sapiens_hsa052050.13981829
93Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.13910628
94Vibrio cholerae infection_Homo sapiens_hsa051100.13832562
95Notch signaling pathway_Homo sapiens_hsa043300.12654547
96Regulation of actin cytoskeleton_Homo sapiens_hsa048100.12528037
97mTOR signaling pathway_Homo sapiens_hsa041500.11134301
98PPAR signaling pathway_Homo sapiens_hsa033200.10842179
99Sphingolipid metabolism_Homo sapiens_hsa006000.09940550
100HTLV-I infection_Homo sapiens_hsa051660.09895109
101Galactose metabolism_Homo sapiens_hsa000520.09768649
102Proteasome_Homo sapiens_hsa030500.09204144
103MAPK signaling pathway_Homo sapiens_hsa040100.09098038
104Fructose and mannose metabolism_Homo sapiens_hsa000510.09086893
105Transcriptional misregulation in cancer_Homo sapiens_hsa052020.08338696
106Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.08333920
107FoxO signaling pathway_Homo sapiens_hsa040680.07475721
108Endocytosis_Homo sapiens_hsa041440.06822450
109Fatty acid biosynthesis_Homo sapiens_hsa000610.06498892
110Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.05981789
111Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.05867948
112Primary bile acid biosynthesis_Homo sapiens_hsa001200.04612298
113Renal cell carcinoma_Homo sapiens_hsa052110.02093251

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