ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	L-phenylalanine catabolic process (GO:0006559)	6.85070382
2	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	6.85070382
3	L-phenylalanine metabolic process (GO:0006558)	6.68048742
4	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	6.68048742
5	alpha-linolenic acid metabolic process (GO:0036109)	6.42764560
6	aromatic amino acid family catabolic process (GO:0009074)	5.94526693
7	glyoxylate metabolic process (GO:0046487)	5.80056271
8	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	5.66925838
9	cysteine metabolic process (GO:0006534)	5.64347068
10	sulfur amino acid catabolic process (GO:0000098)	5.28864156
11	lysine catabolic process (GO:0006554)	5.28496781
12	lysine metabolic process (GO:0006553)	5.28496781
13	kynurenine metabolic process (GO:0070189)	5.20465779
14	low-density lipoprotein particle clearance (GO:0034383)	5.18172521
15	tryptophan catabolic process (GO:0006569)	5.16030754
16	indole-containing compound catabolic process (GO:0042436)	5.16030754
17	indolalkylamine catabolic process (GO:0046218)	5.16030754
18	fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)	5.14580126
19	bile acid biosynthetic process (GO:0006699)	5.13974609
20	tryptophan metabolic process (GO:0006568)	4.95626791
21	triglyceride catabolic process (GO:0019433)	4.95331108
22	amino-acid betaine metabolic process (GO:0006577)	4.95202263
23	serine family amino acid catabolic process (GO:0009071)	4.90442394
24	cellular ketone body metabolic process (GO:0046950)	4.74289641
25	neutral lipid catabolic process (GO:0046461)	4.71749260
26	acylglycerol catabolic process (GO:0046464)	4.71749260
27	positive regulation of triglyceride lipase activity (GO:0061365)	4.67602727
28	positive regulation of lipoprotein lipase activity (GO:0051006)	4.67602727
29	high-density lipoprotein particle remodeling (GO:0034375)	4.67463019
30	short-chain fatty acid metabolic process (GO:0046459)	4.65384780
31	homocysteine metabolic process (GO:0050667)	4.52860275
32	serine family amino acid biosynthetic process (GO:0009070)	4.49573111
33	negative regulation of cholesterol transport (GO:0032375)	4.42677806
34	negative regulation of sterol transport (GO:0032372)	4.42677806
35	serine family amino acid metabolic process (GO:0009069)	4.40033670
36	alpha-amino acid catabolic process (GO:1901606)	4.38107671
37	biotin metabolic process (GO:0006768)	4.38039980
38	aromatic amino acid family metabolic process (GO:0009072)	4.36369292
39	aspartate family amino acid catabolic process (GO:0009068)	4.35973146
40	bile acid metabolic process (GO:0008206)	4.35734669
41	regulation of triglyceride catabolic process (GO:0010896)	4.35652857
42	reverse cholesterol transport (GO:0043691)	4.34856139
43	regulation of cholesterol esterification (GO:0010872)	4.34807590
44	fatty acid beta-oxidation (GO:0006635)	4.29107741
45	fatty acid homeostasis (GO:0055089)	4.28935295
46	cellular modified amino acid catabolic process (GO:0042219)	4.28486456
47	ethanol oxidation (GO:0006069)	4.26361194
48	regulation of complement activation (GO:0030449)	4.21969127
49	* very long-chain fatty acid metabolic process (GO:0000038)	4.21256331
50	urea metabolic process (GO:0019627)	4.21072472
51	urea cycle (GO:0000050)	4.21072472
52	negative regulation of fibrinolysis (GO:0051918)	4.20866298
53	regulation of sequestering of triglyceride (GO:0010889)	4.20198769
54	glutamate metabolic process (GO:0006536)	4.19712488
55	cellular amino acid catabolic process (GO:0009063)	4.18149491
56	polyketide metabolic process (GO:0030638)	4.17377588
57	doxorubicin metabolic process (GO:0044598)	4.17377588
58	daunorubicin metabolic process (GO:0044597)	4.17377588
59	ketone body metabolic process (GO:1902224)	4.14837907
60	protein carboxylation (GO:0018214)	4.14460039
61	peptidyl-glutamic acid carboxylation (GO:0017187)	4.14460039
62	protein-lipid complex remodeling (GO:0034368)	4.12518238
63	macromolecular complex remodeling (GO:0034367)	4.12518238
64	plasma lipoprotein particle remodeling (GO:0034369)	4.12518238
65	carnitine metabolic process (GO:0009437)	4.11883110
66	diacylglycerol metabolic process (GO:0046339)	4.09825650
67	L-serine metabolic process (GO:0006563)	4.09380062
68	fatty acid oxidation (GO:0019395)	4.07025046
69	glycine metabolic process (GO:0006544)	4.05228440
70	lipid oxidation (GO:0034440)	4.03026884
71	tyrosine metabolic process (GO:0006570)	4.02906612
72	drug catabolic process (GO:0042737)	4.01283547
73	acetyl-CoA metabolic process (GO:0006084)	3.99476641
74	regulation of fibrinolysis (GO:0051917)	3.99321432
75	drug transmembrane transport (GO:0006855)	3.98304045
76	very-low-density lipoprotein particle assembly (GO:0034379)	3.98192298
77	fatty acid catabolic process (GO:0009062)	3.96758773
78	nitrogen cycle metabolic process (GO:0071941)	3.91590761
79	monocarboxylic acid catabolic process (GO:0072329)	3.91454199
80	blood coagulation, intrinsic pathway (GO:0007597)	3.91219240
81	phospholipid efflux (GO:0033700)	3.90943591
82	organic acid catabolic process (GO:0016054)	3.89479362
83	carboxylic acid catabolic process (GO:0046395)	3.89479362
84	NADH metabolic process (GO:0006734)	3.88166966
85	complement activation, alternative pathway (GO:0006957)	3.85168290
86	urate metabolic process (GO:0046415)	3.84758269
87	response to nitrosative stress (GO:0051409)	3.77546937
88	amine catabolic process (GO:0009310)	3.76345174
89	cellular biogenic amine catabolic process (GO:0042402)	3.76345174
90	low-density lipoprotein particle remodeling (GO:0034374)	3.76198065
91	linoleic acid metabolic process (GO:0043651)	3.75110892
92	cellular glucuronidation (GO:0052695)	3.73857236
93	coenzyme catabolic process (GO:0009109)	3.73496471
94	triglyceride homeostasis (GO:0070328)	3.72324210
95	acylglycerol homeostasis (GO:0055090)	3.72324210
96	2-oxoglutarate metabolic process (GO:0006103)	3.71756742
97	plasma lipoprotein particle clearance (GO:0034381)	3.71466630
98	* acyl-CoA metabolic process (GO:0006637)	3.70455841
99	* thioester metabolic process (GO:0035383)	3.70455841
100	regulation of cholesterol metabolic process (GO:0090181)	3.67510085
101	fibrinolysis (GO:0042730)	3.66099918
102	primary alcohol metabolic process (GO:0034308)	3.65677079
103	glycerolipid catabolic process (GO:0046503)	3.64932476
104	aminoglycoside antibiotic metabolic process (GO:0030647)	3.63681155
105	indolalkylamine metabolic process (GO:0006586)	3.62716646
106	benzene-containing compound metabolic process (GO:0042537)	3.60284087
107	regulation of cholesterol biosynthetic process (GO:0045540)	3.59185092
108	regulation of cholesterol homeostasis (GO:2000188)	3.58348094
109	positive regulation of fatty acid beta-oxidation (GO:0032000)	3.56934590
110	cholesterol efflux (GO:0033344)	3.55825615
111	drug transport (GO:0015893)	3.54143174
112	arginine metabolic process (GO:0006525)	3.53342196
113	plasma lipoprotein particle assembly (GO:0034377)	3.50732858
114	flavonoid metabolic process (GO:0009812)	3.49817284
115	regulation of protein activation cascade (GO:2000257)	3.48761410
116	exogenous drug catabolic process (GO:0042738)	3.48256142
117	regulation of plasminogen activation (GO:0010755)	3.48143004
118	drug metabolic process (GO:0017144)	3.46942442
119	positive regulation of fatty acid biosynthetic process (GO:0045723)	3.46924763
120	primary alcohol catabolic process (GO:0034310)	3.46660996
121	negative regulation of lipase activity (GO:0060192)	3.45284629
122	aldehyde catabolic process (GO:0046185)	3.42751951
123	dicarboxylic acid biosynthetic process (GO:0043650)	3.42437072
124	acute-phase response (GO:0006953)	3.40471629
125	ethanol metabolic process (GO:0006067)	3.39479193
126	positive regulation of lipid catabolic process (GO:0050996)	3.37708485
127	uronic acid metabolic process (GO:0006063)	3.36294032
128	glucuronate metabolic process (GO:0019585)	3.36294032
129	oxaloacetate metabolic process (GO:0006107)	3.34988280
130	neutral lipid biosynthetic process (GO:0046460)	3.33763350
131	acylglycerol biosynthetic process (GO:0046463)	3.33763350
132	thioester biosynthetic process (GO:0035384)	3.28707944
133	acyl-CoA biosynthetic process (GO:0071616)	3.28707944
134	intestinal cholesterol absorption (GO:0030299)	3.27775193
135	triglyceride biosynthetic process (GO:0019432)	3.27536877
136	triglyceride metabolic process (GO:0006641)	3.27014895
137	epoxygenase P450 pathway (GO:0019373)	3.25139203
138	positive regulation of lipid storage (GO:0010884)	3.24819674
139	xenobiotic catabolic process (GO:0042178)	3.24427246
140	regulation of triglyceride metabolic process (GO:0090207)	3.19574048
141	acylglycerol metabolic process (GO:0006639)	3.16609116
142	positive regulation of triglyceride metabolic process (GO:0090208)	3.15430355
143	oxidative demethylation (GO:0070989)	3.14905476
144	regulation of cholesterol storage (GO:0010885)	3.14894646
145	response to phenylpropanoid (GO:0080184)	3.11675575
146	fatty-acyl-CoA biosynthetic process (GO:0046949)	3.10984290
147	neutral lipid metabolic process (GO:0006638)	3.10815085
148	regulation of lipoprotein particle clearance (GO:0010984)	3.05500841

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	* RXR_22158963_ChIP-Seq_LIVER_Mouse	7.57594895
2	* PPARA_22158963_ChIP-Seq_LIVER_Mouse	6.48780076
3	* LXR_22158963_ChIP-Seq_LIVER_Mouse	5.90760583
4	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	5.78496487
5	EGR1_23403033_ChIP-Seq_LIVER_Mouse	5.50328091
6	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	4.46640419
7	* CEBPA_23403033_ChIP-Seq_LIVER_Mouse	4.00760684
8	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.48405460
9	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	3.15301613
10	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	3.09915290
11	* CLOCK_20551151_ChIP-Seq_293T_Human	2.45482576
12	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	2.42732802
13	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.42660896
14	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.23304271
15	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	2.16850285
16	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	10.6413129
17	TP63_17297297_ChIP-ChIP_HaCaT_Human	1.97413271
18	* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat	1.87255943
19	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	1.83933869
20	ZNF263_19887448_ChIP-Seq_K562_Human	1.79556618
21	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.69832371
22	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.65954161
23	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.59951310
24	* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	1.43907392
25	FOXA2_19822575_ChIP-Seq_HepG2_Human	1.43759659
26	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.38408573
27	* SOX2_27498859_Chip-Seq_STOMACH_Mouse	1.37232040
28	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.32876289
29	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.31810842
30	GATA4_25053715_ChIP-Seq_YYC3_Human	1.22787594
31	HNF4A_19822575_ChIP-Seq_HepG2_Human	1.21814925
32	HIF1A_21447827_ChIP-Seq_MCF-7_Human	1.20893860
33	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.16145342
34	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.14261326
35	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.12800358
36	NR0B1_18358816_ChIP-ChIP_MESCs_Mouse	1.12658984
37	ESR1_21235772_ChIP-Seq_MCF-7_Human	1.12577089
38	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	1.10485561
39	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.08825451
40	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.05583959
41	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.04687394
42	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.03697341
43	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.03476577
44	GATA1_22025678_ChIP-Seq_K562_Human	1.02939937
45	SALL4_18804426_ChIP-ChIP_XEN_Mouse	0.99668557
46	TET1_21451524_ChIP-Seq_MESCs_Mouse	0.98755905
47	DNAJC2_21179169_ChIP-ChIP_NT2_Human	0.98276740
48	CDX2_20551321_ChIP-Seq_CACO-2_Human	0.98089122
49	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	0.97525566
50	ERG_21242973_ChIP-ChIP_JURKAT_Human	0.93652836
51	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	0.92843819
52	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.91528624
53	* TCF3_18692474_ChIP-Seq_MEFs_Mouse	0.90635016
54	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.90536012
55	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	0.90100573
56	ELF1_20517297_ChIP-Seq_JURKAT_Human	0.88795305
57	FOXO3_23340844_ChIP-Seq_DLD1_Human	0.87873781
58	* RXRA_24833708_ChIP-Seq_LIVER_Mouse	0.87257483
59	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	0.86835763
60	EOMES_21245162_ChIP-Seq_HESCs_Human	0.85752390
61	CBP_21632823_ChIP-Seq_H3396_Human	0.85657530
62	ATF3_23680149_ChIP-Seq_GBM1-GSC_Human	0.84970233
63	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	0.83990886
64	AR_21909140_ChIP-Seq_LNCAP_Human	0.83885877
65	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	0.83366485
66	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	0.82734729
67	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	0.82566969
68	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.82050072
69	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	0.81903158
70	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.81023025
71	LXR_22292898_ChIP-Seq_THP-1_Human	0.80429754
72	CTCF_18555785_ChIP-Seq_MESCs_Mouse	0.79751463
73	* SOX2_18692474_ChIP-Seq_MEFs_Mouse	0.79678660
74	SOX2_20726797_ChIP-Seq_SW620_Human	0.79644591
75	SA1_22415368_ChIP-Seq_MEFs_Mouse	0.78860349
76	RAD21_21589869_ChIP-Seq_MESCs_Mouse	0.77797642
77	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	0.77777700
78	RACK7_27058665_Chip-Seq_MCF-7_Human	0.77766874
79	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	0.77735083
80	* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse	0.77599175
81	SA1_27219007_Chip-Seq_ERYTHROID_Human	0.77454110
82	HTT_18923047_ChIP-ChIP_STHdh_Human	0.77337559
83	BCOR_27268052_Chip-Seq_Bcells_Human	0.76531433
84	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.75948281
85	CTCF_20526341_ChIP-Seq_ESCs_Human	0.75931363
86	BCL6_27268052_Chip-Seq_Bcells_Human	0.75328405
87	STAT3_1855785_ChIP-Seq_MESCs_Mouse	0.74768983
88	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	0.74430765
89	P63_26484246_Chip-Seq_KERATINOCYTES_Human	0.72800663
90	* SOX2_21211035_ChIP-Seq_LN229_Human	0.72118905
91	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.71792427
92	PPAR_26484153_Chip-Seq_NCI-H1993_Human	0.71643177
93	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	0.71058281
94	ERG_20517297_ChIP-Seq_VCAP_Human	0.70361813
95	ESR1_20079471_ChIP-ChIP_T-47D_Human	0.69691820
96	FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	0.69435251
97	CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse	0.67926719
98	E2F1_20622854_ChIP-Seq_HELA_Human	0.66450480
99	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	0.66304886
100	SA1_27219007_Chip-Seq_Bcells_Human	0.65567321
101	TBX5_21415370_ChIP-Seq_HL-1_Mouse	0.64703263
102	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	0.64580291
103	NRF2_20460467_ChIP-Seq_MEFs_Mouse	0.64571535
104	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	0.64571535
105	* NANOG_18692474_ChIP-Seq_MEFs_Mouse	0.62477609
106	NANOG_18700969_ChIP-ChIP_MESCs_Mouse	0.62039529
107	* TP53_20018659_ChIP-ChIP_R1E_Mouse	0.61648840
108	GATA3_24758297_ChIP-Seq_MCF-7_Human	0.61177709
109	TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.60048733
110	GATA6_25053715_ChIP-Seq_YYC3_Human	0.59482165
111	GATA3_20176728_ChIP-ChIP_TSCs_Mouse	0.59134005
112	ESR1_22446102_ChIP-Seq_UTERUS_Mouse	0.58970485
113	RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	0.57902950
114	SMC3_22415368_ChIP-Seq_MEFs_Mouse	0.57261426
115	SOX9_24532713_ChIP-Seq_HFSC_Mouse	0.56451727
116	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	0.55867147
117	TBX20_22080862_ChIP-Seq_HEART_Mouse	0.55853196
118	TBX20_22328084_ChIP-Seq_HEART_Mouse	0.55853196
119	CEBPB_22108803_ChIP-Seq_LS180_Human	0.55386739
120	AR_20517297_ChIP-Seq_VCAP_Human	0.54407385
121	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.54221399
122	SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse	0.53830978
123	STAT3_19079543_ChIP-ChIP_MESCs_Mouse	0.52927163
124	ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human	0.52325825
125	FOXA1_25552417_ChIP-Seq_VCAP_Human	0.52066703
126	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.51023622
127	EGR1_19032775_ChIP-ChIP_M12_Human	0.50873338
128	* OCT4_18692474_ChIP-Seq_MEFs_Mouse	0.50870946
129	* SOX2_18358816_ChIP-ChIP_MESCs_Mouse	0.50003442
130	CSB_26484114_Chip-Seq_FIBROBLAST_Human	0.49785927
131	POU5F1_16518401_ChIP-PET_MESCs_Mouse	0.49708213
132	RARB_24833708_ChIP-Seq_LIVER_Mouse	0.49240147
133	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	0.49204513
134	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.47350318
135	CTCF_27219007_Chip-Seq_Bcells_Human	0.46949136
136	NFIB_24661679_ChIP-Seq_LUNG_Mouse	0.46223495
137	TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	0.45812083

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002139_abnormal_hepatobiliary_system	8.17326901
2	MP0005360_urolithiasis	6.90784360
3	MP0005365_abnormal_bile_salt	5.57368774
4	MP0005085_abnormal_gallbladder_physiolo	5.52976653
5	MP0008875_abnormal_xenobiotic_pharmacok	4.57862709
6	MP0003806_abnormal_nucleotide_metabolis	3.61657461
7	MP0003252_abnormal_bile_duct	3.33793701
8	MP0005332_abnormal_amino_acid	3.23134875
9	MP0009840_abnormal_foam_cell	3.17850793
10	MP0010329_abnormal_lipoprotein_level	3.14996298
11	MP0005083_abnormal_biliary_tract	2.72333271
12	MP0004019_abnormal_vitamin_homeostasis	2.70545360
13	MP0003195_calcinosis	2.66194552
14	MP0002876_abnormal_thyroid_physiology	2.36278324
15	MP0001666_abnormal_nutrient_absorption	2.32695432
16	MP0004185_abnormal_adipocyte_glucose	2.15584646
17	MP0003191_abnormal_cellular_cholesterol	2.03675038
18	MP0002118_abnormal_lipid_homeostasis	1.99446046
19	MP0005058_abnormal_lysosome_morphology	1.99132296
20	MP0002138_abnormal_hepatobiliary_system	1.98599708
21	MP0003011_delayed_dark_adaptation	1.97187836
22	MP0005375_adipose_tissue_phenotype	1.89427729
23	MP0005451_abnormal_body_composition	1.81389100
24	MP0000609_abnormal_liver_physiology	1.76535506
25	MP0000751_myopathy	1.69389600
26	MP0002254_reproductive_system_inflammat	1.68680141
27	MP0008438_abnormal_cutaneous_collagen	1.67711997
28	MP0000003_abnormal_adipose_tissue	1.65425900
29	MP0009643_abnormal_urine_homeostasis	1.64877291
30	MP0003950_abnormal_plasma_membrane	1.57388829
31	MP0005319_abnormal_enzyme/_coenzyme	1.50855684
32	MP0003186_abnormal_redox_activity	1.49432295
33	MP0005584_abnormal_enzyme/coenzyme_acti	1.48021723
34	MP0009780_abnormal_chondrocyte_physiolo	1.47723432
35	MP0002970_abnormal_white_adipose	1.47230580
36	MP0000013_abnormal_adipose_tissue	1.43691358
37	MP0005334_abnormal_fat_pad	1.42391512
38	MP0005535_abnormal_body_temperature	1.42332121
39	MP0003646_muscle_fatigue	1.40017700
40	MP0005379_endocrine/exocrine_gland_phen	1.39035498
41	MP0003868_abnormal_feces_composition	1.35201028
42	MP0009115_abnormal_fat_cell	1.33406566
43	MP0003959_abnormal_lean_body	1.24927448
44	MP0005275_abnormal_skin_tensile	1.21519210
45	MP0001764_abnormal_homeostasis	1.21481574
46	MP0004043_abnormal_pH_regulation	1.20967937
47	MP0003705_abnormal_hypodermis_morpholog	1.19396127
48	MP0003136_yellow_coat_color	1.18026427
49	MP0003690_abnormal_glial_cell	1.16467591
50	MP0002796_impaired_skin_barrier	1.15016329
51	MP0005636_abnormal_mineral_homeostasis	1.13951677
52	MP0005647_abnormal_sex_gland	1.05870561
53	MP0002837_dystrophic_cardiac_calcinosis	1.05082007
54	MP0000749_muscle_degeneration	1.03803740
55	MP0004233_abnormal_muscle_weight	1.02744824
56	MP0009053_abnormal_anal_canal	1.01675156
57	MP0006138_congestive_heart_failure	1.01433441
58	MP0000566_synostosis	0.98964222
59	MP0001756_abnormal_urination	0.96222945
60	MP0009384_cardiac_valve_regurgitation	0.95675267
61	MP0005503_abnormal_tendon_morphology	0.95412635
62	MP0005448_abnormal_energy_balance	0.94688724
63	MP0005646_abnormal_pituitary_gland	0.93948976
64	MP0000579_abnormal_nail_morphology	0.93560689
65	MP0005452_abnormal_adipose_tissue	0.90986645
66	MP0002098_abnormal_vibrissa_morphology	0.89088044
67	MP0005330_cardiomyopathy	0.88468715
68	MP0000598_abnormal_liver_morphology	0.86934636
69	MP0003329_amyloid_beta_deposits	0.84669544
70	MP0002136_abnormal_kidney_physiology	0.84449049
71	MP0002249_abnormal_larynx_morphology	0.84215075
72	MP0000604_amyloidosis	0.83797120
73	MP0010234_abnormal_vibrissa_follicle	0.83044767
74	MP0006036_abnormal_mitochondrial_physio	0.79999499
75	MP0000759_abnormal_skeletal_muscle	0.78706206
76	MP0009764_decreased_sensitivity_to	0.77626524
77	MP0002282_abnormal_trachea_morphology	0.77553424
78	MP0003656_abnormal_erythrocyte_physiolo	0.76235992
79	MP0005408_hypopigmentation	0.74747282
80	MP0004087_abnormal_muscle_fiber	0.74647498
81	MP0003879_abnormal_hair_cell	0.72387403
82	MP0002108_abnormal_muscle_morphology	0.71907974
83	MP0004036_abnormal_muscle_relaxation	0.71594438
84	MP0003953_abnormal_hormone_level	0.71577297
85	MP0002090_abnormal_vision	0.71389994
86	MP0004130_abnormal_muscle_cell	0.69821560
87	MP0009642_abnormal_blood_homeostasis	0.69409407
88	MP0003638_abnormal_response/metabolism_	0.68030407
89	MP0004145_abnormal_muscle_electrophysio	0.68023200
90	MP0001544_abnormal_cardiovascular_syste	0.67399232
91	MP0005385_cardiovascular_system_phenoty	0.67399232
92	MP0000647_abnormal_sebaceous_gland	0.67292686
93	MP0002269_muscular_atrophy	0.66614452
94	MP0005666_abnormal_adipose_tissue	0.66168544
95	MP0002972_abnormal_cardiac_muscle	0.65322889
96	MP0009697_abnormal_copulation	0.64413134
97	MP0005376_homeostasis/metabolism_phenot	0.64054130
98	MP0004885_abnormal_endolymph	0.64050325
99	MP0004782_abnormal_surfactant_physiolog	0.63742991
100	MP0005165_increased_susceptibility_to	0.61322014
101	MP0000343_altered_response_to	0.60754480
102	MP0005501_abnormal_skin_physiology	0.60684131
103	MP0009379_abnormal_foot_pigmentation	0.60214721
104	MP0009763_increased_sensitivity_to	0.60192487
105	MP0005248_abnormal_Harderian_gland	0.60066728
106	MP0010678_abnormal_skin_adnexa	0.60059707
107	MP0003828_pulmonary_edema	0.59989397
108	MP0000377_abnormal_hair_follicle	0.59924715
109	MP0005620_abnormal_muscle_contractility	0.59832993
110	MP0002106_abnormal_muscle_physiology	0.59413769
111	MP0004381_abnormal_hair_follicle	0.59076766
112	MP0003279_aneurysm	0.58768787
113	MP0004264_abnormal_extraembryonic_tissu	0.58059217
114	MP0005369_muscle_phenotype	0.57540323
115	MP0005164_abnormal_response_to	0.56825321
116	MP0001765_abnormal_ion_homeostasis	0.56092732
117	MP0002971_abnormal_brown_adipose	0.55171069
118	MP0005645_abnormal_hypothalamus_physiol	0.54022753
119	MP0010368_abnormal_lymphatic_system	0.53965611
120	MP0000467_abnormal_esophagus_morphology	0.52946545
121	MP0000537_abnormal_urethra_morphology	0.52449826
122	MP0002127_abnormal_cardiovascular_syste	0.52359633
123	MP0005670_abnormal_white_adipose	0.52297794
124	MP0002909_abnormal_adrenal_gland	0.51684097
125	MP0005084_abnormal_gallbladder_morpholo	0.51227774
126	MP0001881_abnormal_mammary_gland	0.49579725
127	MP0000383_abnormal_hair_follicle	0.49425771
128	MP0001340_abnormal_eyelid_morphology	0.48878755
129	MP0002078_abnormal_glucose_homeostasis	0.48502361
130	MP0005395_other_phenotype	0.47663672
131	MP0004858_abnormal_nervous_system	0.47422041
132	MP0003075_altered_response_to	0.47237913
133	MP0002168_other_aberrant_phenotype	0.46124120
134	MP0005220_abnormal_exocrine_pancreas	0.45902775
135	MP0003300_gastrointestinal_ulcer	0.45520544
136	MP0004272_abnormal_basement_membrane	0.45294320
137	MP0009765_abnormal_xenobiotic_induced	0.45067730
138	MP0008469_abnormal_protein_level	0.45054206
139	MP0000230_abnormal_systemic_arterial	0.44149352
140	MP0003878_abnormal_ear_physiology	0.43839027
141	MP0005377_hearing/vestibular/ear_phenot	0.43839027
142	MP0001958_emphysema	0.43206652
143	MP0005266_abnormal_metabolism	0.41623201
144	MP0010030_abnormal_orbit_morphology	0.40067613
145	MP0006035_abnormal_mitochondrial_morpho	0.39951310
146	MP0002092_abnormal_eye_morphology	0.39256093
147	MP0004883_abnormal_blood_vessel	0.39251471
148	MP0003942_abnormal_urinary_system	0.38996069
149	MP0001661_extended_life_span	0.38831254
150	MP0000462_abnormal_digestive_system	0.37748774

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of aromatic amino acid family metabolism (HP:0004338)	6.63321967
2	Deep venous thrombosis (HP:0002625)	6.01358383
3	Intrahepatic cholestasis (HP:0001406)	6.00372475
4	Xanthomatosis (HP:0000991)	5.92883968
5	Abnormality of monocarboxylic acid metabolism (HP:0010996)	5.58065460
6	Hypobetalipoproteinemia (HP:0003563)	5.25467049
7	Hyperglycinuria (HP:0003108)	5.14230910
8	Abnormality of glycine metabolism (HP:0010895)	5.06184563
9	Abnormality of serine family amino acid metabolism (HP:0010894)	5.06184563
10	Hyperglycinemia (HP:0002154)	4.88505986
11	Hyperammonemia (HP:0001987)	4.86656301
12	Hyperlipoproteinemia (HP:0010980)	4.77147277
13	Ketosis (HP:0001946)	4.70921190
14	Prolonged partial thromboplastin time (HP:0003645)	4.55155411
15	Abnormality of glutamine family amino acid metabolism (HP:0010902)	4.33487873
16	Abnormality of aspartate family amino acid metabolism (HP:0010899)	4.17493076
17	Abnormality of fatty-acid metabolism (HP:0004359)	4.06420806
18	Hypoglycemic coma (HP:0001325)	4.06330776
19	Hypolipoproteinemia (HP:0010981)	4.02260000
20	Abnormality of sulfur amino acid metabolism (HP:0004339)	3.97637865
21	Systemic lupus erythematosus (HP:0002725)	3.97159083
22	Delayed CNS myelination (HP:0002188)	3.85065556
23	Ketoacidosis (HP:0001993)	3.78272571
24	Epidermoid cyst (HP:0200040)	3.76843416
25	Gout (HP:0001997)	3.70491050
26	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	3.66844787
27	Hypoalphalipoproteinemia (HP:0003233)	3.64798186
28	Abnormality of methionine metabolism (HP:0010901)	3.59683664
29	Increased serum pyruvate (HP:0003542)	3.53417356
30	Rhabdomyolysis (HP:0003201)	3.49835280
31	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	3.40693509
32	Dicarboxylic aciduria (HP:0003215)	3.38279354
33	Abnormality of dicarboxylic acid metabolism (HP:0010995)	3.38279354
34	Myoglobinuria (HP:0002913)	3.34144136
35	Joint hemorrhage (HP:0005261)	3.29834939
36	Fat malabsorption (HP:0002630)	3.22186635
37	Abnormality of purine metabolism (HP:0004352)	3.18437200
38	Oligomenorrhea (HP:0000876)	3.16848105
39	Abnormality of serum amino acid levels (HP:0003112)	3.16400582
40	Metabolic acidosis (HP:0001942)	3.12352872
41	Hypercholesterolemia (HP:0003124)	3.10291983
42	Abnormality of nucleobase metabolism (HP:0010932)	3.09431909
43	Mitral stenosis (HP:0001718)	3.06007524
44	Spastic diplegia (HP:0001264)	3.02905252
45	Abnormality of glycolysis (HP:0004366)	2.99993584
46	Abnormality of the common coagulation pathway (HP:0010990)	2.98541326
47	Reduced antithrombin III activity (HP:0001976)	2.97107770
48	Exercise-induced myalgia (HP:0003738)	2.95242380
49	Abnormality of pyrimidine metabolism (HP:0004353)	2.91421327
50	Complement deficiency (HP:0004431)	2.84143408
51	Lethargy (HP:0001254)	2.82671015
52	Proximal tubulopathy (HP:0000114)	2.80902100
53	Malnutrition (HP:0004395)	2.77448887
54	Vascular calcification (HP:0004934)	2.76705570
55	Glomerulonephritis (HP:0000099)	2.70902088
56	Hyperbilirubinemia (HP:0002904)	2.67981986
57	Alkalosis (HP:0001948)	2.63814743
58	Increased purine levels (HP:0004368)	2.62707761
59	Hyperuricemia (HP:0002149)	2.62707761
60	Hemorrhage of the eye (HP:0011885)	2.61410150
61	Hepatocellular carcinoma (HP:0001402)	2.60918017
62	Generalized aminoaciduria (HP:0002909)	2.58335917
63	Glycosuria (HP:0003076)	2.53540378
64	Abnormality of urine glucose concentration (HP:0011016)	2.53540378
65	Vertebral compression fractures (HP:0002953)	2.51728204
66	Abnormality of glycolipid metabolism (HP:0010969)	2.47240181
67	Abnormality of liposaccharide metabolism (HP:0010968)	2.47240181
68	Abnormality of glycosphingolipid metabolism (HP:0004343)	2.47240181
69	Cardiovascular calcification (HP:0011915)	2.42331671
70	Hepatic necrosis (HP:0002605)	2.42064542
71	Abnormality of the intrinsic pathway (HP:0010989)	2.41654862
72	Rickets (HP:0002748)	2.40742367
73	Enlarged kidneys (HP:0000105)	2.40335584
74	Vomiting (HP:0002013)	2.39672975
75	Conjugated hyperbilirubinemia (HP:0002908)	2.38741034
76	Nemaline bodies (HP:0003798)	2.38065021
77	Cerebral edema (HP:0002181)	2.34982557
78	Irritability (HP:0000737)	2.34914424
79	Confusion (HP:0001289)	2.34085834
80	Steatorrhea (HP:0002570)	2.32861808
81	Beaking of vertebral bodies (HP:0004568)	2.32243789
82	Hypokalemic alkalosis (HP:0001949)	2.31660470
83	Hypoglycemic seizures (HP:0002173)	2.31616783
84	Protrusio acetabuli (HP:0003179)	2.31471482
85	Acanthosis nigricans (HP:0000956)	2.30430275
86	Muscle fiber inclusion bodies (HP:0100299)	2.27817206
87	Mesangial abnormality (HP:0001966)	2.27239970
88	Hypertriglyceridemia (HP:0002155)	2.26416304
89	Purpura (HP:0000979)	2.25981961
90	Abnormality of proline metabolism (HP:0010907)	2.24650415
91	Hydroxyprolinuria (HP:0003080)	2.24650415
92	Back pain (HP:0003418)	2.24175837
93	Late onset (HP:0003584)	2.23366165
94	Increased muscle lipid content (HP:0009058)	2.22433392
95	Urinary glycosaminoglycan excretion (HP:0003541)	2.22379783
96	Mucopolysacchariduria (HP:0008155)	2.22379783
97	Abnormality of mucopolysaccharide metabolism (HP:0011020)	2.21272149
98	Abnormality of polysaccharide metabolism (HP:0011012)	2.21272149
99	Abnormality of glycosaminoglycan metabolism (HP:0004371)	2.21272149
100	Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)	2.19380387
101	Sensorimotor neuropathy (HP:0007141)	2.19270678
102	Respiratory distress (HP:0002098)	2.18507220
103	Abnormality of carpal bone ossification (HP:0006257)	2.16491510
104	Asymmetric septal hypertrophy (HP:0001670)	2.14619534
105	Neonatal onset (HP:0003623)	2.07399081
106	3-Methylglutaconic aciduria (HP:0003535)	2.05799564
107	Esophageal varix (HP:0002040)	2.05522779
108	Type 1 muscle fiber predominance (HP:0003803)	2.04383647
109	Pancreatitis (HP:0001733)	2.04226461
110	Hyperactive renin-angiotensin system (HP:0000841)	2.03048702
111	Amyloidosis (HP:0011034)	2.02243535
112	Vacuolated lymphocytes (HP:0001922)	2.01954995
113	Skin nodule (HP:0200036)	2.01575180
114	Abnormality of vitamin metabolism (HP:0100508)	1.99912144
115	Methylmalonic aciduria (HP:0012120)	1.97621185
116	Abnormal cartilage morphology (HP:0002763)	1.96521655
117	Hyperphosphaturia (HP:0003109)	1.95654327
118	Abnormal biliary tract physiology (HP:0012439)	1.95435886
119	Bile duct proliferation (HP:0001408)	1.95435886
120	Myocardial infarction (HP:0001658)	1.93088709
121	Nausea (HP:0002018)	1.91849982
122	Abnormal delivery (HP:0001787)	1.91586037
123	Abnormality of complement system (HP:0005339)	1.90648468
124	Dysostosis multiplex (HP:0000943)	1.89197451
125	Acute encephalopathy (HP:0006846)	1.88148670
126	Increased circulating renin level (HP:0000848)	1.87531184
127	Abnormal pupillary function (HP:0007686)	1.85246132
128	Renal cortical cysts (HP:0000803)	1.85205599
129	Nephrolithiasis (HP:0000787)	1.84718174
130	Turricephaly (HP:0000262)	1.84649790
131	Metabolic alkalosis (HP:0200114)	1.82958875
132	Opisthotonus (HP:0002179)	1.82945529
133	Brushfield spots (HP:0001088)	1.82416076
134	Gingival bleeding (HP:0000225)	1.81944943
135	Abnormal tarsal ossification (HP:0008369)	1.80878188
136	Abnormal urine output (HP:0012590)	1.79413379
137	Gonadal dysgenesis (HP:0000133)	1.78943607
138	Spontaneous abortion (HP:0005268)	1.78236257
139	Epiphyseal stippling (HP:0010655)	1.77671432
140	Ulnar deviation of the wrist (HP:0003049)	1.77428825
141	Neurofibrillary tangles (HP:0002185)	1.76118358
142	Muscle stiffness (HP:0003552)	1.75895157
143	Cholelithiasis (HP:0001081)	1.75660507
144	Abnormal enzyme/coenzyme activity (HP:0012379)	1.74899428
145	Hypophosphatemic rickets (HP:0004912)	1.74352842
146	Abnormal urine phosphate concentration (HP:0012599)	1.69588715
147	Tachypnea (HP:0002789)	1.67580056

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	BCKDK	6.33822744
2	SIK1	4.34048454
3	WNK3	3.01740263
4	OBSCN	2.82004675
5	WNK4	2.79564668
6	PKN2	2.77248657
7	MYLK	2.75896685
8	FGFR4	2.72123845
9	TESK1	2.69281340
10	ERN1	2.62549982
11	LIMK1	2.59646178
12	MUSK	2.54496961
13	OXSR1	2.52264875
14	TRIB3	2.38424599
15	ARAF	2.37079254
16	EPHB1	2.34765463
17	MAPK15	2.30051422
18	MAPKAPK3	2.16898589
19	LMTK2	2.10067970
20	ICK	2.07732892
21	STK39	1.96206551
22	PTK6	1.94239802
23	FGFR2	1.92733994
24	MST1R	1.90982657
25	PIM2	1.90622414
26	LATS1	1.89112575
27	EPHB2	1.86475457
28	ERBB4	1.75051155
29	PIK3CG	1.57847671
30	STK16	1.52377345
31	LRRK2	1.48983162
32	TBK1	1.48821309
33	FLT3	1.46179864
34	STK38L	1.44977322
35	NUAK1	1.33870482
36	ERBB2	1.30037364
37	MAP3K12	1.28972394
38	MAPK11	1.23141868
39	MAP2K2	1.22584030
40	INSRR	1.17184596
41	MAP3K10	1.17078313
42	MET	1.14478320
43	TTN	1.14297940
44	PDK3	1.09994405
45	PDK4	1.09994405
46	GSK3A	1.07727924
47	DAPK3	1.04497176
48	DYRK1B	1.03607675
49	PHKG2	0.99730528
50	PHKG1	0.99730528
51	MAP3K7	0.96127975
52	SGK223	0.94000557
53	SGK494	0.94000557
54	ABL2	0.91931359
55	MAP3K1	0.89213441
56	TIE1	0.86856327
57	RIPK1	0.86802422
58	IRAK1	0.86286026
59	CDK6	0.86072432
60	PRKAA2	0.85367095
61	MAP3K3	0.82574675
62	IRAK3	0.81205588
63	MAPK4	0.78721138
64	GRK6	0.78176438
65	DAPK2	0.78028797
66	FER	0.77548291
67	NEK9	0.76826463
68	CAMK1	0.76554140
69	PTK2	0.75943258
70	PAK3	0.73198540
71	CSNK1G1	0.72615307
72	PDGFRA	0.70284839
73	MAPK12	0.69128425
74	RPS6KC1	0.68091235
75	RPS6KL1	0.68091235
76	MAP3K11	0.67765631
77	CAMK1D	0.66578327
78	TGFBR2	0.66353102
79	EPHA4	0.66051480
80	PRKCZ	0.65542228
81	EPHA3	0.64913909
82	PINK1	0.64308190
83	PDK2	0.63959694
84	FGFR1	0.62661767
85	TGFBR1	0.62136494
86	IRAK2	0.61146529
87	PAK4	0.58966211
88	GRK1	0.58853247
89	MAP2K1	0.58789926
90	GRK5	0.57664635
91	PBK	0.57192806
92	IGF1R	0.57110792
93	VRK2	0.56834768
94	DAPK1	0.56601037
95	EEF2K	0.56323294
96	NME2	0.55788242
97	RPS6KA2	0.55712544
98	RPS6KA6	0.55324545
99	MAP2K6	0.53968890
100	GRK7	0.53539820
101	MAP3K6	0.52264564
102	PAK2	0.52225142
103	PRKACA	0.51974870
104	CAMK2G	0.50920376
105	PRKACG	0.50788989
106	PRKG1	0.50277618
107	CDK8	0.47830929
108	PRKD2	0.47011542
109	DDR2	0.46914838
110	DYRK3	0.46711715
111	CAMK2D	0.46205622
112	STK4	0.46115204
113	ILK	0.43993376
114	CSNK1G3	0.43240418
115	CSNK1A1L	0.43065327
116	MAPK3	0.42827412
117	KDR	0.42726356
118	TAOK2	0.42050296
119	TYRO3	0.41584792
120	PRKD1	0.40809157
121	JAK2	0.40448523
122	MAP4K2	0.40413351
123	CDK9	0.40328079
124	BRAF	0.40059494
125	MST4	0.40011845
126	MAPKAPK5	0.38520413
127	AKT2	0.38394157
128	MAP2K4	0.38156101
129	MAP2K3	0.37874345
130	MOS	0.37557118
131	PIK3CA	0.36897089
132	NEK1	0.36896715
133	IKBKB	0.35342049
134	AURKA	0.34335098
135	RET	0.34017839
136	PRKAA1	0.33366090
137	ROCK2	0.32628622
138	PKN1	0.32076432
139	PDPK1	0.32069152
140	SCYL2	0.31221099
141	TYK2	0.29975113
142	NTRK2	0.29302320
143	RPS6KA1	0.29127994
144	DYRK2	0.26688776
145	BMX	0.26368681
146	BCR	0.26318116
147	EPHA2	0.26023176
148	MAP3K2	0.24045785

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nitrogen metabolism_Homo sapiens_hsa00910	3.66389524
2	Primary bile acid biosynthesis_Homo sapiens_hsa00120	3.55809524
3	* Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	3.34091904
4	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	3.21783428
5	Fatty acid degradation_Homo sapiens_hsa00071	3.11299865
6	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.82339731
7	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	2.76581158
8	Butanoate metabolism_Homo sapiens_hsa00650	2.66860535
9	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	2.56451564
10	Tryptophan metabolism_Homo sapiens_hsa00380	2.53481261
11	Propanoate metabolism_Homo sapiens_hsa00640	2.53273564
12	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.49252144
13	Arginine biosynthesis_Homo sapiens_hsa00220	2.45164745
14	Fatty acid metabolism_Homo sapiens_hsa01212	2.44905315
15	Peroxisome_Homo sapiens_hsa04146	2.31714119
16	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	2.24442686
17	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	2.20033753
18	PPAR signaling pathway_Homo sapiens_hsa03320	2.16503230
19	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	2.01789398
20	beta-Alanine metabolism_Homo sapiens_hsa00410	1.97538737
21	* Fatty acid elongation_Homo sapiens_hsa00062	1.92519646
22	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.89120360
23	Histidine metabolism_Homo sapiens_hsa00340	1.87855509
24	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.80840857
25	Chemical carcinogenesis_Homo sapiens_hsa05204	1.79148459
26	Complement and coagulation cascades_Homo sapiens_hsa04610	1.78286132
27	Pyruvate metabolism_Homo sapiens_hsa00620	1.72788426
28	Retinol metabolism_Homo sapiens_hsa00830	1.55117759
29	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.50274167
30	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.50110697
31	Bile secretion_Homo sapiens_hsa04976	1.46450320
32	Sulfur metabolism_Homo sapiens_hsa00920	1.43936183
33	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.42156617
34	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.39162880
35	Carbon metabolism_Homo sapiens_hsa01200	1.38867431
36	Selenocompound metabolism_Homo sapiens_hsa00450	1.37129077
37	Steroid biosynthesis_Homo sapiens_hsa00100	1.36355600
38	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.30075093
39	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.28926280
40	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.27044159
41	Arginine and proline metabolism_Homo sapiens_hsa00330	1.26139038
42	Folate biosynthesis_Homo sapiens_hsa00790	1.22957598
43	Phenylalanine metabolism_Homo sapiens_hsa00360	1.22902184
44	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.19695958
45	Tyrosine metabolism_Homo sapiens_hsa00350	1.16428129
46	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.11201491
47	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.09282789
48	Caffeine metabolism_Homo sapiens_hsa00232	1.08855980
49	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.06080501
50	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.04787737
51	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.04727503
52	Glutathione metabolism_Homo sapiens_hsa00480	1.04712454
53	Other glycan degradation_Homo sapiens_hsa00511	1.04138398
54	Sulfur relay system_Homo sapiens_hsa04122	0.99591476
55	Fat digestion and absorption_Homo sapiens_hsa04975	0.97274458
56	Lysine degradation_Homo sapiens_hsa00310	0.94613822
57	ABC transporters_Homo sapiens_hsa02010	0.92647764
58	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.91632002
59	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.86100469
60	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.83925252
61	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.78841843
62	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.76538681
63	Glycerolipid metabolism_Homo sapiens_hsa00561	0.71122755
64	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.65955151
65	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.65298556
66	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.64716559
67	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.63103242
68	Pentose phosphate pathway_Homo sapiens_hsa00030	0.62180268
69	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.59204366
70	* Metabolic pathways_Homo sapiens_hsa01100	0.53205306
71	Lysosome_Homo sapiens_hsa04142	0.45404387
72	One carbon pool by folate_Homo sapiens_hsa00670	0.44710457
73	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.39379509
74	Alzheimers disease_Homo sapiens_hsa05010	0.26263506
75	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.26129376
76	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.26114728
77	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.25825061
78	Galactose metabolism_Homo sapiens_hsa00052	0.25115615
79	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.19524251
80	Insulin resistance_Homo sapiens_hsa04931	0.18186182
81	Sphingolipid metabolism_Homo sapiens_hsa00600	0.17475271
82	Cardiac muscle contraction_Homo sapiens_hsa04260	0.17469810
83	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.15918321
84	Pertussis_Homo sapiens_hsa05133	0.14625872
85	Basal cell carcinoma_Homo sapiens_hsa05217	0.14374527
86	ECM-receptor interaction_Homo sapiens_hsa04512	0.12757792
87	Linoleic acid metabolism_Homo sapiens_hsa00591	0.12305528
88	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.09072900
89	Huntingtons disease_Homo sapiens_hsa05016	0.07860155
90	Insulin signaling pathway_Homo sapiens_hsa04910	0.07017591
91	Mineral absorption_Homo sapiens_hsa04978	0.05908652
92	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.05202393
93	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.03007198
94	Protein digestion and absorption_Homo sapiens_hsa04974	0.02175598
95	Prion diseases_Homo sapiens_hsa05020	0.02126778
96	AMPK signaling pathway_Homo sapiens_hsa04152	0.01806006
97	Glucagon signaling pathway_Homo sapiens_hsa04922	0.00453108
98	Hippo signaling pathway_Homo sapiens_hsa04390	-0.1379480
99	Central carbon metabolism in cancer_Homo sapiens_hsa05230	-0.1331322
100	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	-0.1287829
101	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	-0.1272367
102	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	-0.1248073
103	Ovarian steroidogenesis_Homo sapiens_hsa04913	-0.1223007
104	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	-0.1080670
105	Renin-angiotensin system_Homo sapiens_hsa04614	-0.1038357
106	Glycosaminoglycan degradation_Homo sapiens_hsa00531	-0.0970362
107	Ether lipid metabolism_Homo sapiens_hsa00565	-0.0921562
108	Parkinsons disease_Homo sapiens_hsa05012	-0.0771792
109	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	-0.0768669
110	Oxidative phosphorylation_Homo sapiens_hsa00190	-0.0350172
111	Thyroid hormone synthesis_Homo sapiens_hsa04918	-0.0347016
112	Hedgehog signaling pathway_Homo sapiens_hsa04340	-0.0278541
113	Bladder cancer_Homo sapiens_hsa05219	-0.0250770

ACOT1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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