ACOT11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the acyl-CoA thioesterase family which catalyse the conversion of activated fatty acids to the corresponding non-esterified fatty acid and coenzyme A. Expression of a mouse homolog in brown adipose tissue is induced by low temperatures and repressed by warm temperatures. Higher levels of expression of the mouse homolog has been found in obesity-resistant mice compared with obesity-prone mice, suggesting a role of acyl-CoA thioesterase 11 in obesity. Alternative splicing results in transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1indole-containing compound catabolic process (GO:0042436)4.85066999
2indolalkylamine catabolic process (GO:0046218)4.85066999
3tryptophan catabolic process (GO:0006569)4.85066999
4indolalkylamine metabolic process (GO:0006586)4.61560503
5kynurenine metabolic process (GO:0070189)4.55952911
6cilium or flagellum-dependent cell motility (GO:0001539)4.22517810
7tryptophan metabolic process (GO:0006568)4.10108210
8behavioral response to nicotine (GO:0035095)4.09376639
9alanine transport (GO:0032328)4.01371530
10polyketide metabolic process (GO:0030638)3.97814125
11doxorubicin metabolic process (GO:0044598)3.97814125
12daunorubicin metabolic process (GO:0044597)3.97814125
13cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.97133253
14fucose catabolic process (GO:0019317)3.93127176
15L-fucose metabolic process (GO:0042354)3.93127176
16L-fucose catabolic process (GO:0042355)3.93127176
17regulation of hippo signaling (GO:0035330)3.92475572
18NADH metabolic process (GO:0006734)3.88875685
19carnitine shuttle (GO:0006853)3.83878751
20glycine transport (GO:0015816)3.64726062
21cell communication by electrical coupling (GO:0010644)3.62240037
22detection of light stimulus involved in sensory perception (GO:0050962)3.61871335
23detection of light stimulus involved in visual perception (GO:0050908)3.61871335
24detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.55346003
25cellular ketone body metabolic process (GO:0046950)3.52942507
26photoreceptor cell maintenance (GO:0045494)3.47737182
27cellular potassium ion homeostasis (GO:0030007)3.47363403
28NAD biosynthetic process (GO:0009435)3.45993460
29sodium ion export (GO:0071436)3.45592415
30biotin metabolic process (GO:0006768)3.40011122
31proline transport (GO:0015824)3.38142094
32interkinetic nuclear migration (GO:0022027)3.37209393
33fatty acid transmembrane transport (GO:1902001)3.35064540
34locomotory exploration behavior (GO:0035641)3.33801452
35positive regulation of developmental pigmentation (GO:0048087)3.33581093
36epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.32896548
37regulation of pigment cell differentiation (GO:0050932)3.31169154
38indole-containing compound metabolic process (GO:0042430)3.31012071
39flavonoid metabolic process (GO:0009812)3.25201750
40cellular biogenic amine catabolic process (GO:0042402)3.21662301
41amine catabolic process (GO:0009310)3.21662301
42tricarboxylic acid cycle (GO:0006099)3.18604590
43carnitine transmembrane transport (GO:1902603)3.17303421
44drug catabolic process (GO:0042737)3.15681800
45ketone body metabolic process (GO:1902224)3.15155119
46signal peptide processing (GO:0006465)3.14331336
47snRNA transcription (GO:0009301)3.12959963
48regulation of gene silencing by RNA (GO:0060966)3.12695392
49regulation of posttranscriptional gene silencing (GO:0060147)3.12695392
50regulation of gene silencing by miRNA (GO:0060964)3.12695392
51negative regulation of cytosolic calcium ion concentration (GO:0051481)3.12309984
52lysine catabolic process (GO:0006554)3.09808939
53lysine metabolic process (GO:0006553)3.09808939
54short-chain fatty acid metabolic process (GO:0046459)3.09533254
55fatty acid beta-oxidation (GO:0006635)3.08378137
56sulfation (GO:0051923)3.08221208
57potassium ion import (GO:0010107)3.07932494
58regulation of fatty acid oxidation (GO:0046320)3.07097331
59axoneme assembly (GO:0035082)3.05718791
60regulation of sarcomere organization (GO:0060297)3.05662459
61monoubiquitinated protein deubiquitination (GO:0035520)3.03856342
62amino-acid betaine transport (GO:0015838)3.03081379
63carnitine transport (GO:0015879)3.03081379
64regulation of skeletal muscle contraction (GO:0014819)3.01897692
65auditory receptor cell stereocilium organization (GO:0060088)3.00908091
66oxidative demethylation (GO:0070989)3.00836651
67establishment of protein localization to Golgi (GO:0072600)2.98957223
68aminoglycoside antibiotic metabolic process (GO:0030647)2.98851795
69membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.97386536
70negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.96654277
71benzene-containing compound metabolic process (GO:0042537)2.96632461
72negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.96606948
73negative regulation of translation, ncRNA-mediated (GO:0040033)2.96606948
74regulation of translation, ncRNA-mediated (GO:0045974)2.96606948
75positive regulation of fatty acid oxidation (GO:0046321)2.94897407
76succinate metabolic process (GO:0006105)2.91466220
77neural tube formation (GO:0001841)2.90864250
78regulation of sequestering of triglyceride (GO:0010889)2.89974186
79reflex (GO:0060004)2.89670520
80tricarboxylic acid metabolic process (GO:0072350)2.89597315
81protein K48-linked deubiquitination (GO:0071108)2.87793249
82L-amino acid import (GO:0043092)2.87567495
83thyroid hormone metabolic process (GO:0042403)2.87507181
84regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.84665283
85striated muscle atrophy (GO:0014891)2.84044285
86cilium movement (GO:0003341)2.83269274
87synaptic vesicle maturation (GO:0016188)2.81937396
88regulation of beta-amyloid formation (GO:1902003)2.80068930
89positive regulation of fatty acid beta-oxidation (GO:0032000)2.77286405
90negative regulation of mast cell activation (GO:0033004)2.76375036
91regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.74258276
92UDP-N-acetylglucosamine metabolic process (GO:0006047)2.73373019
93lipid oxidation (GO:0034440)2.73217417
94cellular response to ATP (GO:0071318)2.73047796
95cell communication involved in cardiac conduction (GO:0086065)2.72168004
96carnitine metabolic process (GO:0009437)2.71169559
97aspartate family amino acid catabolic process (GO:0009068)2.70616476
98primary amino compound metabolic process (GO:1901160)2.69656517
99regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.69252554
100protein K11-linked deubiquitination (GO:0035871)2.68525994
101positive regulation of triglyceride biosynthetic process (GO:0010867)2.68145203
102fatty acid oxidation (GO:0019395)2.67365830
103fatty acid catabolic process (GO:0009062)2.66724453
104activation of protein kinase A activity (GO:0034199)2.66243771
105relaxation of cardiac muscle (GO:0055119)2.65585947
106protein K63-linked deubiquitination (GO:0070536)2.65520513
107serotonin metabolic process (GO:0042428)2.62068190
108alpha-linolenic acid metabolic process (GO:0036109)2.61392956
109aromatic amino acid family catabolic process (GO:0009074)2.61196665
110cholesterol catabolic process (GO:0006707)2.60681788
111sterol catabolic process (GO:0016127)2.60681788
112vocalization behavior (GO:0071625)2.60307545
113motile cilium assembly (GO:0044458)2.59096942
114rRNA catabolic process (GO:0016075)2.59016076
115epithelial cilium movement (GO:0003351)2.58894426
1162-oxoglutarate metabolic process (GO:0006103)2.58592848
117cellular response to exogenous dsRNA (GO:0071360)2.58195633
118skeletal muscle adaptation (GO:0043501)2.57806032
119cellular response to ethanol (GO:0071361)2.57683395
120DNA deamination (GO:0045006)2.57511849
121neurotransmitter-gated ion channel clustering (GO:0072578)2.56871892
122triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.56230344
123gamma-aminobutyric acid transport (GO:0015812)2.55092301
124cAMP catabolic process (GO:0006198)2.54433177
125response to pheromone (GO:0019236)2.54142730
126pyridine nucleotide biosynthetic process (GO:0019363)2.53733839
127nicotinamide nucleotide biosynthetic process (GO:0019359)2.53733839
128potassium ion homeostasis (GO:0055075)2.53676407
129behavioral response to ethanol (GO:0048149)2.53581219
130negative regulation of protein localization to cell surface (GO:2000009)2.53215100
131fatty acid homeostasis (GO:0055089)2.52913216
132multicellular organism reproduction (GO:0032504)2.52502351
133exogenous drug catabolic process (GO:0042738)2.51745574
134regulation of triglyceride biosynthetic process (GO:0010866)2.50312770
135phosphatidylinositol acyl-chain remodeling (GO:0036149)2.50084500
136retinal cone cell development (GO:0046549)2.49038660
137neuronal action potential (GO:0019228)2.48786288
138membrane depolarization during action potential (GO:0086010)2.48189628
139L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.48041652
140negative regulation of systemic arterial blood pressure (GO:0003085)2.47017755
141positive regulation of fatty acid transport (GO:2000193)2.46968536
142synaptic vesicle docking involved in exocytosis (GO:0016081)2.46359803
143fructose metabolic process (GO:0006000)2.46123306
144dicarboxylic acid catabolic process (GO:0043649)2.45369836
145regulation of action potential (GO:0098900)2.45041113
146cilium organization (GO:0044782)2.44995133
147amino acid import (GO:0043090)2.44934887
148transepithelial transport (GO:0070633)2.44050552
149regulation of triglyceride catabolic process (GO:0010896)2.44020164
150valine metabolic process (GO:0006573)2.43856579
151membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.42341195
152cellular sodium ion homeostasis (GO:0006883)2.42057527
153pericardium development (GO:0060039)2.41084002
154amino-acid betaine metabolic process (GO:0006577)2.41010881
155aromatic amino acid family metabolic process (GO:0009072)2.40968423
156spinal cord motor neuron differentiation (GO:0021522)2.40854924
157quaternary ammonium group transport (GO:0015697)2.40580529
158regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.40562038
159phospholipid translocation (GO:0045332)2.40399607
160lipid translocation (GO:0034204)2.40399607
161cellular response to sterol (GO:0036315)2.38462390
162monocarboxylic acid catabolic process (GO:0072329)2.37686673
163positive regulation of glycolytic process (GO:0045821)2.37647054
164positive regulation of triglyceride metabolic process (GO:0090208)2.37441567
165regulation of synaptic vesicle exocytosis (GO:2000300)2.37433802
166alkaloid metabolic process (GO:0009820)2.37311322
167cilium assembly (GO:0042384)2.36929004
168regulation of acyl-CoA biosynthetic process (GO:0050812)2.36450005
169regulation of fatty acid beta-oxidation (GO:0031998)2.36054605
170membrane repolarization (GO:0086009)2.35920303
171response to auditory stimulus (GO:0010996)2.35078108
172positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.34000604
173regulation of short-term neuronal synaptic plasticity (GO:0048172)2.33981406
174regulation of synaptic vesicle transport (GO:1902803)2.33202721
175branched-chain amino acid catabolic process (GO:0009083)2.32761031
176positive regulation of potassium ion transmembrane transport (GO:1901381)2.32544544
177regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.32435549
178regulation of membrane repolarization (GO:0060306)2.32424165
179positive regulation of cellular amide metabolic process (GO:0034250)2.31999247
180regulation of ARF protein signal transduction (GO:0032012)2.30617493
181glutamate secretion (GO:0014047)2.24920939
182neurotransmitter secretion (GO:0007269)2.24800471
183adenine nucleotide transport (GO:0051503)2.24296643
184branched-chain amino acid metabolic process (GO:0009081)2.23897165
185nucleoside diphosphate catabolic process (GO:0009134)2.22498590
186neuronal action potential propagation (GO:0019227)2.21031737
187positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.20239954
188hormone catabolic process (GO:0042447)2.19804906
189detection of calcium ion (GO:0005513)2.19536241
190fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.19439225
191positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.18500454
192acyl-CoA biosynthetic process (GO:0071616)2.17992595
193thioester biosynthetic process (GO:0035384)2.17992595

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.50682779
2VDR_22108803_ChIP-Seq_LS180_Human3.19155870
3ZNF274_21170338_ChIP-Seq_K562_Hela3.02484665
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.91280673
5ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.47837954
6DROSHA_22980978_ChIP-Seq_HELA_Human2.41389534
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.22430368
8RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.22223571
9IGF1R_20145208_ChIP-Seq_DFB_Human2.19239691
10GBX2_23144817_ChIP-Seq_PC3_Human2.18220061
11RXR_22158963_ChIP-Seq_LIVER_Mouse2.15953098
12CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.12584641
13SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.09846392
14POU3F2_20337985_ChIP-ChIP_501MEL_Human1.99911957
15SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.96896623
16FLI1_27457419_Chip-Seq_LIVER_Mouse1.96213659
17* LXR_22158963_ChIP-Seq_LIVER_Mouse1.89316394
18SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.88018322
19ER_23166858_ChIP-Seq_MCF-7_Human1.86979910
20MTF2_20144788_ChIP-Seq_MESCs_Mouse1.86393071
21NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.83446567
22CTBP1_25329375_ChIP-Seq_LNCAP_Human1.80335600
23P300_19829295_ChIP-Seq_ESCs_Human1.79414116
24* REST_21632747_ChIP-Seq_MESCs_Mouse1.78098843
25PPARA_22158963_ChIP-Seq_LIVER_Mouse1.77173460
26TAF15_26573619_Chip-Seq_HEK293_Human1.76677827
27FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.68169165
28EZH2_18974828_ChIP-Seq_MESCs_Mouse1.67982021
29RNF2_18974828_ChIP-Seq_MESCs_Mouse1.67982021
30JARID2_20075857_ChIP-Seq_MESCs_Mouse1.67683663
31SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.66448158
32JARID2_20064375_ChIP-Seq_MESCs_Mouse1.62838604
33PCGF2_27294783_Chip-Seq_ESCs_Mouse1.62108285
34IKZF1_21737484_ChIP-ChIP_HCT116_Human1.61946925
35SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.61438813
36* MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.59732568
37RARB_27405468_Chip-Seq_BRAIN_Mouse1.58580672
38SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.57898091
39TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.57161958
40TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.56478098
41CDX2_19796622_ChIP-Seq_MESCs_Mouse1.51615610
42UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.51406229
43TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.51386235
44POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.51386235
45EWS_26573619_Chip-Seq_HEK293_Human1.51038996
46FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.50917010
47IRF8_22096565_ChIP-ChIP_GC-B_Human1.50817485
48EZH2_27294783_Chip-Seq_ESCs_Mouse1.49458319
49CBP_20019798_ChIP-Seq_JUKART_Human1.47892227
50IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.47892227
51FUS_26573619_Chip-Seq_HEK293_Human1.47403905
52THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.47173825
53EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.45615779
54TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.40258237
55TP53_16413492_ChIP-PET_HCT116_Human1.40121196
56* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.39041478
57RXR_22108803_ChIP-Seq_LS180_Human1.37383920
58EED_16625203_ChIP-ChIP_MESCs_Mouse1.35960221
59RNF2_27304074_Chip-Seq_ESCs_Mouse1.35740793
60PCGF2_27294783_Chip-Seq_NPCs_Mouse1.34822068
61* TCF4_22108803_ChIP-Seq_LS180_Human1.34580330
62REST_18959480_ChIP-ChIP_MESCs_Mouse1.34099089
63PRDM14_20953172_ChIP-Seq_ESCs_Human1.33776838
64SMAD3_21741376_ChIP-Seq_EPCs_Human1.32590762
65EGR1_23403033_ChIP-Seq_LIVER_Mouse1.31930827
66MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.31506803
67SUZ12_27294783_Chip-Seq_NPCs_Mouse1.28029397
68PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.27174706
69SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.25813415
70ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.25635534
71* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.25251768
72ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.24658472
73PIAS1_25552417_ChIP-Seq_VCAP_Human1.23367356
74EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.22526817
75SOX2_19829295_ChIP-Seq_ESCs_Human1.21620988
76NANOG_19829295_ChIP-Seq_ESCs_Human1.21620988
77RUNX2_22187159_ChIP-Seq_PCA_Human1.21512954
78TOP2B_26459242_ChIP-Seq_MCF-7_Human1.20911954
79CDX2_22108803_ChIP-Seq_LS180_Human1.20281723
80FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.20148392
81NFE2_27457419_Chip-Seq_LIVER_Mouse1.19943993
82EZH2_27294783_Chip-Seq_NPCs_Mouse1.19523458
83NR3C1_23031785_ChIP-Seq_PC12_Mouse1.19201448
84FOXA2_19822575_ChIP-Seq_HepG2_Human1.18997888
85TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.18836068
86SMAD4_21741376_ChIP-Seq_EPCs_Human1.18671903
87BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.18179824
88EZH2_27304074_Chip-Seq_ESCs_Mouse1.17141675
89GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16614700
90GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.16009002
91CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.15725265
92SMAD_19615063_ChIP-ChIP_OVARY_Human1.15724029
93ZNF217_24962896_ChIP-Seq_MCF-7_Human1.15614386
94* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.15146647
95ERG_21242973_ChIP-ChIP_JURKAT_Human1.14697704
96AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.13947982
97ESR1_20079471_ChIP-ChIP_T-47D_Human1.13207941
98SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.12864481
99SALL1_21062744_ChIP-ChIP_HESCs_Human1.12567677
100IRF1_19129219_ChIP-ChIP_H3396_Human1.12145662
101FLI1_21867929_ChIP-Seq_TH2_Mouse1.12046885
102TP53_22573176_ChIP-Seq_HFKS_Human1.11965242
103FOXA1_21572438_ChIP-Seq_LNCaP_Human1.11451880
104ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.11099954
105ESR2_21235772_ChIP-Seq_MCF-7_Human1.09350656
106* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.09159046
107NR3C1_21868756_ChIP-Seq_MCF10A_Human1.07796530
108VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.07745814
109SMAD4_21799915_ChIP-Seq_A2780_Human1.07043216
110GATA3_21878914_ChIP-Seq_MCF-7_Human1.05911983
111PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.05727434
112BCAT_22108803_ChIP-Seq_LS180_Human1.05163880
113PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.04979384
114CRX_20693478_ChIP-Seq_RETINA_Mouse1.04179139
115SOX2_21211035_ChIP-Seq_LN229_Gbm1.03364884
116TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.02473400
117AR_19668381_ChIP-Seq_PC3_Human1.01852648
118MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.00981986
119AR_21572438_ChIP-Seq_LNCaP_Human1.00943899
120AR_20517297_ChIP-Seq_VCAP_Human1.00750449
121FOXA1_27270436_Chip-Seq_PROSTATE_Human1.00672716
122FOXA1_25329375_ChIP-Seq_VCAP_Human1.00672716
123HOXB7_26014856_ChIP-Seq_BT474_Human1.00247651
124AR_25329375_ChIP-Seq_VCAP_Human1.00113524
125EP300_21415370_ChIP-Seq_HL-1_Mouse0.99419480
126CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.98675609
127TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.98670228
128GATA1_19941826_ChIP-Seq_K562_Human0.98240214
129IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.97764199
130SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.97596377
131OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.97272028
132STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.97139707
133NOTCH1_21737748_ChIP-Seq_TLL_Human0.96375480
134EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.96115741
135SMAD4_21741376_ChIP-Seq_HESCs_Human0.95947963
136STAT3_23295773_ChIP-Seq_U87_Human0.95286541
137GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93856825
138GATA1_19941827_ChIP-Seq_MEL_Mouse0.92824816
139SMAD3_21741376_ChIP-Seq_HESCs_Human0.91702687
140CTNNB1_20460455_ChIP-Seq_HCT116_Human0.90421206
141AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.88785095
142DNAJC2_21179169_ChIP-ChIP_NT2_Human0.88043979
143GATA1_22025678_ChIP-Seq_K562_Human0.87160604
144TBX20_22328084_ChIP-Seq_HEART_Mouse0.86046511
145TBX20_22080862_ChIP-Seq_HEART_Mouse0.86046511
146LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.85720670
147GATA2_19941826_ChIP-Seq_K562_Human0.85122446
148ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.84876991
149* KDM2B_26808549_Chip-Seq_K562_Human0.84849030
150TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.82635093
151GATA2_21666600_ChIP-Seq_HMVEC_Human0.82191633
152* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.81732536
153* KLF4_19829295_ChIP-Seq_ESCs_Human0.81351754
154CDX2_20551321_ChIP-Seq_CACO-2_Human0.80475102
155CTBP2_25329375_ChIP-Seq_LNCAP_Human0.79562125
156* TCF4_23295773_ChIP-Seq_U87_Human0.79091053
157RING1B_27294783_Chip-Seq_ESCs_Mouse0.79025411
158RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.78919459
159ARNT_22903824_ChIP-Seq_MCF-7_Human0.78440113
160AHR_22903824_ChIP-Seq_MCF-7_Human0.77479961
161LXR_22292898_ChIP-Seq_THP-1_Human0.76841761
162SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.76638265
163* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76067080
164EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.75984339
165MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.75188301
166TET1_21490601_ChIP-Seq_MESCs_Mouse0.73922102

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity3.20969816
2MP0000569_abnormal_digit_pigmentation3.17081979
3MP0004043_abnormal_pH_regulation3.11764802
4MP0009780_abnormal_chondrocyte_physiolo2.73802140
5MP0002837_dystrophic_cardiac_calcinosis2.68704231
6MP0005670_abnormal_white_adipose2.65936079
7MP0003646_muscle_fatigue2.54853908
8MP0002909_abnormal_adrenal_gland2.49249681
9MP0005551_abnormal_eye_electrophysiolog2.39903615
10MP0005646_abnormal_pituitary_gland2.37520549
11MP0004130_abnormal_muscle_cell2.33286046
12MP0004145_abnormal_muscle_electrophysio2.28244741
13MP0005365_abnormal_bile_salt2.21637109
14MP0002139_abnormal_hepatobiliary_system2.15310586
15MP0010329_abnormal_lipoprotein_level2.09398916
16MP0003690_abnormal_glial_cell2.02794343
17MP0003183_abnormal_peptide_metabolism2.02454657
18MP0005645_abnormal_hypothalamus_physiol2.00029837
19MP0005360_urolithiasis1.96660134
20MP0005535_abnormal_body_temperature1.96154684
21MP0004858_abnormal_nervous_system1.94534624
22MP0003868_abnormal_feces_composition1.91290834
23MP0008057_abnormal_DNA_replication1.91178086
24MP0003635_abnormal_synaptic_transmissio1.88482275
25MP0009840_abnormal_foam_cell1.86450664
26MP0005085_abnormal_gallbladder_physiolo1.86128062
27MP0008872_abnormal_physiological_respon1.84855910
28MP0000427_abnormal_hair_cycle1.82101077
29MP0001968_abnormal_touch/_nociception1.80423423
30MP0000383_abnormal_hair_follicle1.80395017
31MP0005332_abnormal_amino_acid1.78266967
32MP0005666_abnormal_adipose_tissue1.73367952
33MP0002971_abnormal_brown_adipose1.71800311
34MP0002118_abnormal_lipid_homeostasis1.71567482
35MP0002876_abnormal_thyroid_physiology1.70551642
36MP0001501_abnormal_sleep_pattern1.68333194
37MP0001502_abnormal_circadian_rhythm1.66507974
38MP0003950_abnormal_plasma_membrane1.65014507
39MP0001486_abnormal_startle_reflex1.64047804
40MP0002138_abnormal_hepatobiliary_system1.61414424
41MP0000013_abnormal_adipose_tissue1.60732541
42MP0004215_abnormal_myocardial_fiber1.59662448
43MP0003329_amyloid_beta_deposits1.58939855
44MP0002078_abnormal_glucose_homeostasis1.58571766
45MP0008877_abnormal_DNA_methylation1.57904526
46MP0003879_abnormal_hair_cell1.55093859
47MP0009745_abnormal_behavioral_response1.53439627
48MP0009046_muscle_twitch1.51326768
49MP0008569_lethality_at_weaning1.51275397
50MP0005253_abnormal_eye_physiology1.50840602
51MP0008775_abnormal_heart_ventricle1.49538333
52MP0001666_abnormal_nutrient_absorption1.49113225
53MP0001986_abnormal_taste_sensitivity1.48544876
54MP0002064_seizures1.48178021
55MP0002102_abnormal_ear_morphology1.47456553
56MP0005174_abnormal_tail_pigmentation1.44499215
57MP0004885_abnormal_endolymph1.41171619
58MP0008875_abnormal_xenobiotic_pharmacok1.41134730
59MP0008961_abnormal_basal_metabolism1.37947330
60MP0002736_abnormal_nociception_after1.37928376
61MP0003136_yellow_coat_color1.37520574
62MP0002877_abnormal_melanocyte_morpholog1.33526024
63MP0003252_abnormal_bile_duct1.33185205
64MP0002063_abnormal_learning/memory/cond1.32308774
65MP0002638_abnormal_pupillary_reflex1.32049467
66MP0002735_abnormal_chemical_nociception1.31431372
67MP0000538_abnormal_urinary_bladder1.30994046
68MP0002693_abnormal_pancreas_physiology1.29782435
69MP0002572_abnormal_emotion/affect_behav1.28887563
70MP0006036_abnormal_mitochondrial_physio1.28363912
71MP0004270_analgesia1.27740679
72MP0003633_abnormal_nervous_system1.25672595
73MP0010386_abnormal_urinary_bladder1.25015280
74MP0000751_myopathy1.24518097
75MP0004142_abnormal_muscle_tone1.24424981
76MP0004484_altered_response_of1.23751841
77MP0002822_catalepsy1.21804698
78MP0005266_abnormal_metabolism1.19039812
79MP0005167_abnormal_blood-brain_barrier1.18479108
80MP0003075_altered_response_to1.18458441
81MP0002272_abnormal_nervous_system1.17701265
82MP0002168_other_aberrant_phenotype1.16745470
83MP0005448_abnormal_energy_balance1.16531772
84MP0006276_abnormal_autonomic_nervous1.16296750
85MP0005058_abnormal_lysosome_morphology1.16038716
86MP0003953_abnormal_hormone_level1.15419060
87MP0001440_abnormal_grooming_behavior1.13390758
88MP0005584_abnormal_enzyme/coenzyme_acti1.12758246
89MP0005375_adipose_tissue_phenotype1.11710927
90MP0003172_abnormal_lysosome_physiology1.10820328
91MP0001765_abnormal_ion_homeostasis1.09802540
92MP0005334_abnormal_fat_pad1.09575562
93MP0006072_abnormal_retinal_apoptosis1.09470273
94MP0002067_abnormal_sensory_capabilities1.08162329
95MP0003787_abnormal_imprinting1.07567374
96MP0002734_abnormal_mechanical_nocicepti1.07499696
97MP0004085_abnormal_heartbeat1.05538908
98MP0001944_abnormal_pancreas_morphology1.05114685
99MP0005423_abnormal_somatic_nervous1.04967974
100MP0005410_abnormal_fertilization1.04365017
101MP0003137_abnormal_impulse_conducting1.02989909
102MP0003718_maternal_effect1.00973470
103MP0002653_abnormal_ependyma_morphology1.00553772
104MP0005379_endocrine/exocrine_gland_phen1.00421866
105MP0002557_abnormal_social/conspecific_i0.99971424
106MP0004133_heterotaxia0.99874220
107MP0004147_increased_porphyrin_level0.99253475
108MP0001756_abnormal_urination0.98871882
109MP0009643_abnormal_urine_homeostasis0.98717661
110MP0002332_abnormal_exercise_endurance0.98611889
111MP0005386_behavior/neurological_phenoty0.98406040
112MP0004924_abnormal_behavior0.98406040
113MP0000604_amyloidosis0.98044806
114MP0005377_hearing/vestibular/ear_phenot0.97861063
115MP0003878_abnormal_ear_physiology0.97861063
116MP0003300_gastrointestinal_ulcer0.97030953
117MP0000003_abnormal_adipose_tissue0.96945213
118MP0005620_abnormal_muscle_contractility0.96674272
119MP0002972_abnormal_cardiac_muscle0.96227773
120MP0002254_reproductive_system_inflammat0.96114174
121MP0000609_abnormal_liver_physiology0.94538796
122MP0002229_neurodegeneration0.93266703
123MP0001984_abnormal_olfaction0.93243887
124MP0000372_irregular_coat_pigmentation0.93002469
125MP0004036_abnormal_muscle_relaxation0.91924380
126MP0001664_abnormal_digestion0.91452289
127MP0004185_abnormal_adipocyte_glucose0.90618935
128MP0004084_abnormal_cardiac_muscle0.89898968
129MP0005395_other_phenotype0.89616198
130MP0003195_calcinosis0.88570344
131MP0000631_abnormal_neuroendocrine_gland0.88196343
132MP0001764_abnormal_homeostasis0.88122618
133MP0000470_abnormal_stomach_morphology0.87719411
134MP0005310_abnormal_salivary_gland0.86582600
135MP0000230_abnormal_systemic_arterial0.85844781
136MP0002160_abnormal_reproductive_system0.84813967
137MP0001485_abnormal_pinna_reflex0.84592775
138MP0003045_fibrosis0.84249366
139MP0001970_abnormal_pain_threshold0.84217819
140MP0002069_abnormal_eating/drinking_beha0.84120893
141MP0004019_abnormal_vitamin_homeostasis0.83943852
142MP0002733_abnormal_thermal_nociception0.83039108
143MP0003890_abnormal_embryonic-extraembry0.81939498
144MP0009764_decreased_sensitivity_to0.79084622
145MP0005083_abnormal_biliary_tract0.77678754
146MP0010678_abnormal_skin_adnexa0.77528598
147MP0002928_abnormal_bile_duct0.74927675
148MP0003698_abnormal_male_reproductive0.74493870

Predicted human phenotypes

RankGene SetZ-score
1Hypoglycemic coma (HP:0001325)4.92554611
2Ketoacidosis (HP:0001993)4.60548207
3Pancreatic cysts (HP:0001737)4.58857169
4Hyperglycinuria (HP:0003108)4.54474257
5Hyperventilation (HP:0002883)4.39107083
6Hypoglycemic seizures (HP:0002173)4.06901652
7Pancreatic fibrosis (HP:0100732)3.99263202
8True hermaphroditism (HP:0010459)3.76836721
9Ketosis (HP:0001946)3.76385892
10Hydroxyprolinuria (HP:0003080)3.75133352
11Abnormality of proline metabolism (HP:0010907)3.75133352
12Hyperinsulinemic hypoglycemia (HP:0000825)3.74660126
13Clumsiness (HP:0002312)3.72613746
14Gaze-evoked nystagmus (HP:0000640)3.72350719
15Molar tooth sign on MRI (HP:0002419)3.71811178
16Abnormality of midbrain morphology (HP:0002418)3.71811178
17Chronic hepatic failure (HP:0100626)3.68229258
18Abnormality of serine family amino acid metabolism (HP:0010894)3.64599320
19Abnormality of glycine metabolism (HP:0010895)3.64599320
20Myoglobinuria (HP:0002913)3.60402674
21Congenital stationary night blindness (HP:0007642)3.53804930
22Attenuation of retinal blood vessels (HP:0007843)3.51754708
23Symptomatic seizures (HP:0011145)3.50559176
24Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.47537802
25Abnormality of the renal cortex (HP:0011035)3.41953763
26Nephronophthisis (HP:0000090)3.41733553
27Increased neuronal autofluorescent lipopigment (HP:0002074)3.29737933
28Abnormality of the renal medulla (HP:0100957)3.23313440
29Dicarboxylic aciduria (HP:0003215)3.20603652
30Abnormality of dicarboxylic acid metabolism (HP:0010995)3.20603652
31Generalized aminoaciduria (HP:0002909)3.12664622
32Bundle branch block (HP:0011710)3.10613994
33Cystic liver disease (HP:0006706)3.10502687
34Hyperammonemia (HP:0001987)3.03036867
35Congenital sensorineural hearing impairment (HP:0008527)3.02774448
36Abnormality of fatty-acid metabolism (HP:0004359)3.01160934
37Protruding tongue (HP:0010808)2.97600882
38Focal motor seizures (HP:0011153)2.96829125
39Tubular atrophy (HP:0000092)2.96075881
40Abnormal drinking behavior (HP:0030082)2.92173146
41Polydipsia (HP:0001959)2.92173146
42Abnormality of glutamine family amino acid metabolism (HP:0010902)2.86834290
43Hyperglycinemia (HP:0002154)2.85973686
44Exercise-induced myalgia (HP:0003738)2.83223034
45Abolished electroretinogram (ERG) (HP:0000550)2.78846890
46Dynein arm defect of respiratory motile cilia (HP:0012255)2.74203445
47Absent/shortened dynein arms (HP:0200106)2.74203445
48Late onset (HP:0003584)2.72086481
49Heart block (HP:0012722)2.71828321
50Mucopolysacchariduria (HP:0008155)2.70423815
51Urinary glycosaminoglycan excretion (HP:0003541)2.70423815
52Medial flaring of the eyebrow (HP:0010747)2.69855084
53Abnormality of glycosaminoglycan metabolism (HP:0004371)2.66052837
54Abnormality of mucopolysaccharide metabolism (HP:0011020)2.66052837
55Abnormality of polysaccharide metabolism (HP:0011012)2.66052837
56Atrioventricular block (HP:0001678)2.65939157
57Fair hair (HP:0002286)2.64453076
58Inability to walk (HP:0002540)2.59129691
59Insulin-resistant diabetes mellitus (HP:0000831)2.57048613
60Cerebellar dysplasia (HP:0007033)2.53964664
61Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.53062362
62Broad-based gait (HP:0002136)2.51556184
63Increased cerebral lipofuscin (HP:0011813)2.50414342
64Megalencephaly (HP:0001355)2.50209662
65Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.48264323
66Congenital hepatic fibrosis (HP:0002612)2.48111459
67Hyperglycemia (HP:0003074)2.47755100
68Febrile seizures (HP:0002373)2.45699820
69Bony spicule pigmentary retinopathy (HP:0007737)2.44769387
70Abnormal atrioventricular conduction (HP:0005150)2.44726241
71Absent speech (HP:0001344)2.44302946
72Hemiplegia (HP:0002301)2.41059880
73Stomach cancer (HP:0012126)2.40333520
74Syncope (HP:0001279)2.40188155
75Hepatic necrosis (HP:0002605)2.40135994
76Aplasia/Hypoplasia of the tibia (HP:0005772)2.39918175
77Metabolic alkalosis (HP:0200114)2.38255229
78Visual hallucinations (HP:0002367)2.37460814
79Prolonged QT interval (HP:0001657)2.36696184
80Abnormal ciliary motility (HP:0012262)2.36266298
81Limb hypertonia (HP:0002509)2.35931138
82Dysmetric saccades (HP:0000641)2.34665016
83Methylmalonic aciduria (HP:0012120)2.34262317
84Progressive inability to walk (HP:0002505)2.33929850
85Type II lissencephaly (HP:0007260)2.32257178
86Pheochromocytoma (HP:0002666)2.31527851
87Metabolic acidosis (HP:0001942)2.30856325
88Ventricular fibrillation (HP:0001663)2.29515540
89Dysostosis multiplex (HP:0000943)2.28976060
90Abnormality of alanine metabolism (HP:0010916)2.28848162
91Hyperalaninemia (HP:0003348)2.28848162
92Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.28848162
93Decreased central vision (HP:0007663)2.27988089
94Sudden death (HP:0001699)2.24963387
95Furrowed tongue (HP:0000221)2.23470764
96Hyperactive renin-angiotensin system (HP:0000841)2.23322764
97Polyuria (HP:0000103)2.22671023
98Decreased electroretinogram (ERG) amplitude (HP:0000654)2.22061584
99Abnormality of calcium-phosphate metabolism (HP:0100530)2.21807522
100Action tremor (HP:0002345)2.21053629
101Decreased circulating renin level (HP:0003351)2.19702808
102Hypoalphalipoproteinemia (HP:0003233)2.19526589
103Facial diplegia (HP:0001349)2.19329532
104Tetraparesis (HP:0002273)2.17345419
105Xanthomatosis (HP:0000991)2.13651754
106Abnormal respiratory epithelium morphology (HP:0012253)2.13057775
107Abnormal respiratory motile cilium morphology (HP:0005938)2.13057775
108Large for gestational age (HP:0001520)2.12997848
109Hyperkalemia (HP:0002153)2.11567665
110Postural instability (HP:0002172)2.10003999
111Athetosis (HP:0002305)2.09421815
112Generalized hypopigmentation of hair (HP:0011358)2.08819636
113Palpitations (HP:0001962)2.07627525
114Aplasia/Hypoplasia of the tongue (HP:0010295)2.04715711
115Ventricular arrhythmia (HP:0004308)2.04429080
116Bile duct proliferation (HP:0001408)2.03876232
117Abnormal biliary tract physiology (HP:0012439)2.03876232
118Gait imbalance (HP:0002141)2.03839966
119Widely spaced teeth (HP:0000687)2.03696064
120Congenital primary aphakia (HP:0007707)2.03622771
121Abnormality of renin-angiotensin system (HP:0000847)2.03456660
122Anxiety (HP:0000739)2.02018877
123Amelogenesis imperfecta (HP:0000705)2.01975862
124Central scotoma (HP:0000603)2.01535577
125Abnormal EKG (HP:0003115)2.01481582
126Renal cortical cysts (HP:0000803)2.00453236
127Generalized tonic-clonic seizures (HP:0002069)1.99630488
128Asymmetric septal hypertrophy (HP:0001670)1.99342356
129Methylmalonic acidemia (HP:0002912)1.98586593
130Abnormal eating behavior (HP:0100738)1.96852967
131Bradycardia (HP:0001662)1.96412468
132Gout (HP:0001997)1.94337038
133Atrial fibrillation (HP:0005110)1.93873353
134Sensorimotor neuropathy (HP:0007141)1.93563267
135Status epilepticus (HP:0002133)1.93472329
136Sclerocornea (HP:0000647)1.93122135
137Hypoplastic ischia (HP:0003175)1.92893399
138Abnormality of potassium homeostasis (HP:0011042)1.92872318
139Anencephaly (HP:0002323)1.92836679
140Depression (HP:0000716)1.92376081
141Abnormality of the renal collecting system (HP:0004742)1.90829433
142Chorioretinal atrophy (HP:0000533)1.90552183
143Keratoconus (HP:0000563)1.90218664
144Increased corneal curvature (HP:0100692)1.90218664
145Hyperlipoproteinemia (HP:0010980)1.89726188
146Progressive cerebellar ataxia (HP:0002073)1.89656899
147Rhabdomyolysis (HP:0003201)1.89607766
148Abnormal respiratory motile cilium physiology (HP:0012261)1.88783044
149Focal seizures (HP:0007359)1.85400888
150Nephrogenic diabetes insipidus (HP:0009806)1.85183430
151Abnormal urine output (HP:0012590)1.84453452
152Patellar aplasia (HP:0006443)1.83902701
153Proximal tubulopathy (HP:0000114)1.82843799
154Abnormal social behavior (HP:0012433)1.81657634
155Impaired social interactions (HP:0000735)1.81657634
156Tubulointerstitial nephritis (HP:0001970)1.81073049
157Diplopia (HP:0000651)1.80630386
158Abnormality of binocular vision (HP:0011514)1.80630386
159Enlarged kidneys (HP:0000105)1.79566530
160Confusion (HP:0001289)1.79140607
161Epileptic encephalopathy (HP:0200134)1.78344812
162Abnormality of purine metabolism (HP:0004352)1.78286187
163Tachypnea (HP:0002789)1.78252812
164Hypoplasia of the pons (HP:0012110)1.78207841
165Supranuclear gaze palsy (HP:0000605)1.77947987
166Dysdiadochokinesis (HP:0002075)1.77619524
167Poor coordination (HP:0002370)1.77608238
168Delayed CNS myelination (HP:0002188)1.77033708
169Male pseudohermaphroditism (HP:0000037)1.76780655
170Hyperaldosteronism (HP:0000859)1.75658268
171Lethargy (HP:0001254)1.75140606
172Hypokalemia (HP:0002900)1.74814196
173Genital tract atresia (HP:0001827)1.74662116
174Genetic anticipation (HP:0003743)1.74559095
175Primary atrial arrhythmia (HP:0001692)1.73976913
176Bulbous nose (HP:0000414)1.73794006
177Ileus (HP:0002595)1.73733685
178Macular degeneration (HP:0000608)1.73368113
179Conjugated hyperbilirubinemia (HP:0002908)1.73247397
180Neuroendocrine neoplasm (HP:0100634)1.72689582
181Left ventricular hypertrophy (HP:0001712)1.72557543
182Abnormal rod and cone electroretinograms (HP:0008323)1.72418804
183Increased muscle lipid content (HP:0009058)1.72315717
184Abnormal glucose tolerance (HP:0001952)1.71902406
185Dialeptic seizures (HP:0011146)1.71591523
186Abnormality of the pons (HP:0007361)1.71398198
187Tubulointerstitial abnormality (HP:0001969)1.70820808
188Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.70800615

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B4.77196914
2LMTK23.67375128
3INSRR3.67327241
4BMPR1B3.63632619
5TRIB33.05244638
6SIK12.85663668
7ADRBK22.68175232
8NTRK32.65750657
9BCKDK2.63118408
10PRKD32.46168369
11NTRK22.21864378
12IRAK32.19449332
13EPHA42.16115775
14PHKG12.06278334
15PHKG22.06278334
16GRK11.96548796
17AKT31.93031996
18OBSCN1.86305811
19ZAK1.85640949
20PINK11.85556709
21CAMK1D1.85527250
22TNIK1.83185786
23PDK41.75295013
24PDK31.75295013
25SGK31.73326029
26OXSR11.71789311
27NUAK11.70853977
28TLK11.69906975
29SGK21.68804295
30STK391.62566673
31CAMK1G1.57460450
32RIPK11.51715979
33ERN11.51204023
34CAMKK21.49357518
35FRK1.46681615
36STK381.44584843
37MUSK1.40662353
38CAMKK11.38100175
39MAP4K21.36798407
40WNK31.32411382
41MAP3K21.31857090
42TGFBR11.31652097
43PIK3CG1.26399683
44SGK4941.25988826
45SGK2231.25988826
46SIK21.24771134
47PDPK11.23028081
48TIE11.22595856
49ADRBK11.22071774
50TAOK31.19719240
51MAP2K61.16102416
52MKNK21.15323497
53STK38L1.13888678
54PRKCH1.11220724
55MAP2K71.10226020
56CDC42BPA1.09932133
57PDK11.08234753
58TXK1.08053799
59NTRK11.05789110
60PRKAA21.03467798
61PDGFRA1.02540589
62MAP3K41.01666151
63PRKAA10.97432141
64DAPK20.95777503
65PDK20.94351210
66PAK60.94278039
67NLK0.93442502
68CAMK10.92144897
69MAP2K40.90721167
70TRPM70.89914342
71CDK50.89479908
72TEC0.88820408
73MAPKAPK30.86903055
74CASK0.86594992
75JAK10.83828823
76FGFR40.83643679
77LATS10.82633057
78MELK0.82494344
79WNK10.82384577
80FER0.80602759
81PTK2B0.80558036
82MAPK150.80492519
83IRAK20.79907405
84MAP3K70.79753961
85PTK60.75005824
86WNK40.74078885
87HIPK20.73146841
88PIK3CA0.72105381
89FGFR30.71489864
90MAP2K20.71118090
91KIT0.68795252
92PRKACG0.68161081
93RIPK40.66080764
94NEK10.65613782
95CAMK40.65480377
96SIK30.64248361
97SGK10.63632201
98PRKD10.63496098
99FGFR20.61987474
100MAP3K10.61218299
101RET0.61208061
102IKBKB0.61063300
103CHUK0.59806446
104MAP3K90.59284113
105ITK0.58843810
106MAPK110.58339341
107MINK10.56863305
108MAP3K130.54749185
109PRKD20.54736892
110PKN20.54490643
111JAK20.53260780
112GRK70.53094513
113PRKG20.53024775
114MAPK120.51193376
115PRKCE0.51106657
116DMPK0.50586865
117CAMK2A0.47850660
118IRAK10.46466345
119RPS6KA30.46291790
120PRKCQ0.45397774
121NEK60.44655199
122MYLK0.44605917
123STK30.44259041
124EPHA30.43385226
125BRSK20.43061601
126BRAF0.43004155
127MARK20.42954320
128FES0.42504414
129MARK30.42250527
130CAMK2D0.42168031
131PAK30.41837558
132PKN10.41435301
133BLK0.41290299
134PRKCG0.41050549
135JAK30.40704511
136SYK0.40242147
137CAMK2G0.40235122
138MAPK130.39376053
139ERBB20.38951535
140STK110.38732740
141MAP2K10.38530145
142PRPF4B0.37569674
143RPS6KA60.36957202
144PRKACA0.36358191
145TNK20.35421425
146FLT30.35221321
147TGFBR20.34868440
148MAPKAPK50.33802623
149MST40.33750011
150EIF2AK30.33508324
151PRKCA0.32249036
152RPS6KA50.31906488
153CSNK1A10.29853710
154PRKG10.28642648
155NME10.28318171
156CSNK1A1L0.27367114

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.79379334
2Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.97297564
3Fatty acid degradation_Homo sapiens_hsa000712.94151594
4Linoleic acid metabolism_Homo sapiens_hsa005912.75863605
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.67760803
6Propanoate metabolism_Homo sapiens_hsa006402.57948722
7Fatty acid metabolism_Homo sapiens_hsa012122.57336994
8Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.40420044
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.32956606
10Phototransduction_Homo sapiens_hsa047442.31700368
11Fatty acid biosynthesis_Homo sapiens_hsa000612.24442826
12Maturity onset diabetes of the young_Homo sapiens_hsa049502.20529508
13Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.18379883
14Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.01242333
15Ether lipid metabolism_Homo sapiens_hsa005651.92172899
16Histidine metabolism_Homo sapiens_hsa003401.86448313
17Insulin secretion_Homo sapiens_hsa049111.78691254
18PPAR signaling pathway_Homo sapiens_hsa033201.76134208
192-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.75409315
20Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.75288613
21Butanoate metabolism_Homo sapiens_hsa006501.74252451
22Sulfur metabolism_Homo sapiens_hsa009201.63046882
23Steroid hormone biosynthesis_Homo sapiens_hsa001401.62207761
24Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.60550827
25Chemical carcinogenesis_Homo sapiens_hsa052041.60028619
26Intestinal immune network for IgA production_Homo sapiens_hsa046721.42722279
27Carbohydrate digestion and absorption_Homo sapiens_hsa049731.42667632
28Tryptophan metabolism_Homo sapiens_hsa003801.40538804
29Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.35767038
30Retinol metabolism_Homo sapiens_hsa008301.35511837
31Selenocompound metabolism_Homo sapiens_hsa004501.32465191
32Bile secretion_Homo sapiens_hsa049761.27261414
33Type II diabetes mellitus_Homo sapiens_hsa049301.26935210
34Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.26816403
35Arginine biosynthesis_Homo sapiens_hsa002201.26549726
36Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.25949515
37Arachidonic acid metabolism_Homo sapiens_hsa005901.22900466
38Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.21204044
39Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.19620674
40Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.19303140
41Ovarian steroidogenesis_Homo sapiens_hsa049131.18192552
42Starch and sucrose metabolism_Homo sapiens_hsa005001.15574941
43GABAergic synapse_Homo sapiens_hsa047271.15268801
44Salivary secretion_Homo sapiens_hsa049701.13944865
45Nicotine addiction_Homo sapiens_hsa050331.12934421
46Gastric acid secretion_Homo sapiens_hsa049711.11309835
47Homologous recombination_Homo sapiens_hsa034401.10981597
48Serotonergic synapse_Homo sapiens_hsa047261.07582749
49beta-Alanine metabolism_Homo sapiens_hsa004101.07232292
50Carbon metabolism_Homo sapiens_hsa012001.07094748
51Circadian entrainment_Homo sapiens_hsa047131.07036213
52Cyanoamino acid metabolism_Homo sapiens_hsa004601.05888576
53Insulin resistance_Homo sapiens_hsa049311.05385026
54Pyruvate metabolism_Homo sapiens_hsa006201.05371382
55Synaptic vesicle cycle_Homo sapiens_hsa047211.03465367
56Glucagon signaling pathway_Homo sapiens_hsa049221.02829778
57Asthma_Homo sapiens_hsa053101.02646581
58Glutamatergic synapse_Homo sapiens_hsa047241.02524943
59Circadian rhythm_Homo sapiens_hsa047101.01815233
60Peroxisome_Homo sapiens_hsa041460.97606986
61Aldosterone synthesis and secretion_Homo sapiens_hsa049250.96882645
62Glycerolipid metabolism_Homo sapiens_hsa005610.95983637
63Morphine addiction_Homo sapiens_hsa050320.95329583
64Fructose and mannose metabolism_Homo sapiens_hsa000510.94770932
65Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.93387937
66Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.91020532
67Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.89976021
68Adipocytokine signaling pathway_Homo sapiens_hsa049200.89488344
69Long-term potentiation_Homo sapiens_hsa047200.89100142
70Sphingolipid metabolism_Homo sapiens_hsa006000.88012478
71Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.87986516
72Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.87890600
73Pancreatic secretion_Homo sapiens_hsa049720.86282887
74Fat digestion and absorption_Homo sapiens_hsa049750.85925269
75Galactose metabolism_Homo sapiens_hsa000520.83454463
76Dorso-ventral axis formation_Homo sapiens_hsa043200.83370536
77Fatty acid elongation_Homo sapiens_hsa000620.82708430
78Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.82476126
79Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.81525800
80Amphetamine addiction_Homo sapiens_hsa050310.81489517
81Mineral absorption_Homo sapiens_hsa049780.81260886
82Olfactory transduction_Homo sapiens_hsa047400.81154895
83ABC transporters_Homo sapiens_hsa020100.81115920
84Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.80007701
85Fanconi anemia pathway_Homo sapiens_hsa034600.79752164
86Taste transduction_Homo sapiens_hsa047420.79720312
87Graft-versus-host disease_Homo sapiens_hsa053320.79644923
88Regulation of autophagy_Homo sapiens_hsa041400.78703531
89Cocaine addiction_Homo sapiens_hsa050300.77912656
90Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.77739609
91Renin secretion_Homo sapiens_hsa049240.77300552
92Lysine degradation_Homo sapiens_hsa003100.74828585
93Calcium signaling pathway_Homo sapiens_hsa040200.73538386
94Cholinergic synapse_Homo sapiens_hsa047250.73377311
95Vitamin digestion and absorption_Homo sapiens_hsa049770.71026842
96Insulin signaling pathway_Homo sapiens_hsa049100.71009004
97cAMP signaling pathway_Homo sapiens_hsa040240.70913090
98Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.70342718
99Thyroid hormone synthesis_Homo sapiens_hsa049180.68541060
100Glycerophospholipid metabolism_Homo sapiens_hsa005640.68154398
101Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.67383838
102Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.63877268
103Phosphatidylinositol signaling system_Homo sapiens_hsa040700.62355027
104Dilated cardiomyopathy_Homo sapiens_hsa054140.60456599
105cGMP-PKG signaling pathway_Homo sapiens_hsa040220.59568520
106Primary bile acid biosynthesis_Homo sapiens_hsa001200.56573391
107Glycosaminoglycan degradation_Homo sapiens_hsa005310.55324285
108Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.54583303
109Renin-angiotensin system_Homo sapiens_hsa046140.53352059
110Cardiac muscle contraction_Homo sapiens_hsa042600.53303350
111Caffeine metabolism_Homo sapiens_hsa002320.52922956
112Pentose and glucuronate interconversions_Homo sapiens_hsa000400.51599238
113Protein digestion and absorption_Homo sapiens_hsa049740.48343370
114AMPK signaling pathway_Homo sapiens_hsa041520.47471403
115Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.47079863
116Thyroid hormone signaling pathway_Homo sapiens_hsa049190.46791953
117Dopaminergic synapse_Homo sapiens_hsa047280.46789257
118Lysosome_Homo sapiens_hsa041420.46453037
119Autoimmune thyroid disease_Homo sapiens_hsa053200.45845730
120Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.44341749
121Allograft rejection_Homo sapiens_hsa053300.44153913
122Longevity regulating pathway - mammal_Homo sapiens_hsa042110.42776669
123Type I diabetes mellitus_Homo sapiens_hsa049400.41815688
124Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.38756522
125Primary immunodeficiency_Homo sapiens_hsa053400.38550257
126Biosynthesis of amino acids_Homo sapiens_hsa012300.38323071
127Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.38095182
128GnRH signaling pathway_Homo sapiens_hsa049120.37242767
129Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.34361392
130Collecting duct acid secretion_Homo sapiens_hsa049660.34336763
131Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.33665676
132Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.33494680
133Estrogen signaling pathway_Homo sapiens_hsa049150.33049009
134Basal transcription factors_Homo sapiens_hsa030220.32564588
135Vascular smooth muscle contraction_Homo sapiens_hsa042700.32449846
136Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.32344443
137Oxytocin signaling pathway_Homo sapiens_hsa049210.32044400
138Other glycan degradation_Homo sapiens_hsa005110.31677951
139Long-term depression_Homo sapiens_hsa047300.31013478
140Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.30334385

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