ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	epoxygenase P450 pathway (GO:0019373)	8.46583580
2	omega-hydroxylase P450 pathway (GO:0097267)	8.15638580
3	L-phenylalanine catabolic process (GO:0006559)	7.54937301
4	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	7.54937301
5	L-phenylalanine metabolic process (GO:0006558)	7.23451050
6	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	7.23451050
7	aromatic amino acid family catabolic process (GO:0009074)	6.84651165
8	oxidative demethylation (GO:0070989)	6.40556377
9	tryptophan catabolic process (GO:0006569)	6.21694338
10	indole-containing compound catabolic process (GO:0042436)	6.21694338
11	indolalkylamine catabolic process (GO:0046218)	6.21694338
12	glyoxylate metabolic process (GO:0046487)	6.06059572
13	kynurenine metabolic process (GO:0070189)	5.99116677
14	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	5.96663477
15	blood coagulation, intrinsic pathway (GO:0007597)	5.89466202
16	tryptophan metabolic process (GO:0006568)	5.86224525
17	bile acid biosynthetic process (GO:0006699)	5.85441340
18	phenylpropanoid metabolic process (GO:0009698)	5.77106229
19	cysteine metabolic process (GO:0006534)	5.72155247
20	alpha-linolenic acid metabolic process (GO:0036109)	5.53114280
21	urea metabolic process (GO:0019627)	5.48378896
22	urea cycle (GO:0000050)	5.48378896
23	sulfur amino acid catabolic process (GO:0000098)	5.30486908
24	serine family amino acid catabolic process (GO:0009071)	5.25896839
25	regulation of plasminogen activation (GO:0010755)	5.25481225
26	lysine metabolic process (GO:0006553)	5.19326967
27	lysine catabolic process (GO:0006554)	5.19326967
28	fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)	5.19032005
29	high-density lipoprotein particle remodeling (GO:0034375)	5.17850401
30	negative regulation of fibrinolysis (GO:0051918)	5.15183184
31	nitrogen cycle metabolic process (GO:0071941)	5.05909074
32	homocysteine metabolic process (GO:0050667)	5.04148162
33	peptidyl-glutamic acid carboxylation (GO:0017187)	5.00682206
34	protein carboxylation (GO:0018214)	5.00682206
35	bile acid metabolic process (GO:0008206)	4.98679714
36	aromatic amino acid family metabolic process (GO:0009072)	4.98092845
37	regulation of fibrinolysis (GO:0051917)	4.94729519
38	protein activation cascade (GO:0072376)	4.94185409
39	negative regulation of hemostasis (GO:1900047)	4.91730789
40	negative regulation of blood coagulation (GO:0030195)	4.91730789
41	complement activation, alternative pathway (GO:0006957)	4.88636984
42	ethanol metabolic process (GO:0006067)	4.87102027
43	amino-acid betaine metabolic process (GO:0006577)	4.85675604
44	regulation of protein activation cascade (GO:2000257)	4.84377091
45	S-adenosylmethionine metabolic process (GO:0046500)	4.78774843
46	tyrosine metabolic process (GO:0006570)	4.71091868
47	alpha-amino acid catabolic process (GO:1901606)	4.70789627
48	alkaloid metabolic process (GO:0009820)	4.64944066
49	complement activation (GO:0006956)	4.63918708
50	cellular ketone body metabolic process (GO:0046950)	4.60682016
51	regulation of triglyceride catabolic process (GO:0010896)	4.60080013
52	regulation of cholesterol esterification (GO:0010872)	4.57161226
53	regulation of complement activation (GO:0030449)	4.52216745
54	reverse cholesterol transport (GO:0043691)	4.51951981
55	complement activation, classical pathway (GO:0006958)	4.51826043
56	hormone catabolic process (GO:0042447)	4.51540219
57	drug catabolic process (GO:0042737)	4.50789874
58	negative regulation of cholesterol transport (GO:0032375)	4.48941393
59	negative regulation of sterol transport (GO:0032372)	4.48941393
60	negative regulation of coagulation (GO:0050819)	4.47334614
61	protein-lipid complex remodeling (GO:0034368)	4.45753951
62	macromolecular complex remodeling (GO:0034367)	4.45753951
63	plasma lipoprotein particle remodeling (GO:0034369)	4.45753951
64	acylglycerol homeostasis (GO:0055090)	4.42173680
65	triglyceride homeostasis (GO:0070328)	4.42173680
66	negative regulation of wound healing (GO:0061045)	4.42026917
67	indolalkylamine metabolic process (GO:0006586)	4.40849791
68	serine family amino acid metabolic process (GO:0009069)	4.38472420
69	acute-phase response (GO:0006953)	4.38079806
70	cellular amino acid catabolic process (GO:0009063)	4.37344001
71	glutamate metabolic process (GO:0006536)	4.35802023
72	glycine metabolic process (GO:0006544)	4.33677229
73	regulation of humoral immune response (GO:0002920)	4.32527744
74	cellular glucuronidation (GO:0052695)	4.30178497
75	amine catabolic process (GO:0009310)	4.28395644
76	cellular biogenic amine catabolic process (GO:0042402)	4.28395644
77	drug transmembrane transport (GO:0006855)	4.27985571
78	coenzyme catabolic process (GO:0009109)	4.27981476
79	phospholipid efflux (GO:0033700)	4.27671761
80	cellular modified amino acid catabolic process (GO:0042219)	4.26748943
81	urate metabolic process (GO:0046415)	4.26530152
82	positive regulation of blood coagulation (GO:0030194)	4.25590938
83	positive regulation of hemostasis (GO:1900048)	4.25590938
84	negative regulation of protein activation cascade (GO:2000258)	4.25493518
85	bile acid and bile salt transport (GO:0015721)	4.23729391
86	benzene-containing compound metabolic process (GO:0042537)	4.20027110
87	serine family amino acid biosynthetic process (GO:0009070)	4.13925814
88	opsonization (GO:0008228)	4.13281060
89	fat-soluble vitamin biosynthetic process (GO:0042362)	4.10615670
90	plasma lipoprotein particle clearance (GO:0034381)	4.09524665
91	heme transport (GO:0015886)	4.08473566
92	imidazole-containing compound metabolic process (GO:0052803)	4.07870977
93	negative regulation of lipase activity (GO:0060192)	4.07572196
94	dicarboxylic acid biosynthetic process (GO:0043650)	4.04064703
95	ethanol oxidation (GO:0006069)	4.03073455
96	aldehyde catabolic process (GO:0046185)	4.01965908
97	exogenous drug catabolic process (GO:0042738)	3.99375065
98	short-chain fatty acid metabolic process (GO:0046459)	3.99036966
99	ketone body metabolic process (GO:1902224)	3.98660174
100	cholesterol efflux (GO:0033344)	3.96530581
101	positive regulation of coagulation (GO:0050820)	3.91984325
102	arginine metabolic process (GO:0006525)	3.91848765
103	polyketide metabolic process (GO:0030638)	3.91182675
104	doxorubicin metabolic process (GO:0044598)	3.91182675
105	daunorubicin metabolic process (GO:0044597)	3.91182675
106	cytolysis (GO:0019835)	3.90694500
107	disruption of cells of other organism involved in symbiotic interaction (GO:0051818)	3.88859993
108	killing of cells in other organism involved in symbiotic interaction (GO:0051883)	3.88859993
109	uronic acid metabolic process (GO:0006063)	3.88339241
110	glucuronate metabolic process (GO:0019585)	3.88339241
111	intestinal cholesterol absorption (GO:0030299)	3.86555680
112	carboxylic acid catabolic process (GO:0046395)	3.86481093
113	organic acid catabolic process (GO:0016054)	3.86481093
114	aspartate family amino acid catabolic process (GO:0009068)	3.80154845
115	regulation of bile acid biosynthetic process (GO:0070857)	3.77687717
116	plasma lipoprotein particle assembly (GO:0034377)	3.77160850
117	regulation of lipoprotein particle clearance (GO:0010984)	3.76758232
118	low-density lipoprotein particle remodeling (GO:0034374)	3.72516513
119	fibrinolysis (GO:0042730)	3.72307401
120	regulation of cholesterol homeostasis (GO:2000188)	3.70823149
121	response to mercury ion (GO:0046689)	3.70566363
122	cholesterol homeostasis (GO:0042632)	3.66894266
123	positive regulation of heterotypic cell-cell adhesion (GO:0034116)	3.65468178
124	2-oxoglutarate metabolic process (GO:0006103)	3.65071127
125	flavonoid metabolic process (GO:0009812)	3.64686200
126	phospholipid homeostasis (GO:0055091)	3.64477491
127	cofactor catabolic process (GO:0051187)	3.63041488
128	carnitine metabolic process (GO:0009437)	3.62779305
129	sterol homeostasis (GO:0055092)	3.62633056
130	fatty acid beta-oxidation (GO:0006635)	3.61843887
131	positive regulation of lipoprotein lipase activity (GO:0051006)	3.61831308
132	positive regulation of triglyceride lipase activity (GO:0061365)	3.61831308
133	positive regulation of lipid catabolic process (GO:0050996)	3.61580836
134	fatty acid oxidation (GO:0019395)	3.61150123
135	drug metabolic process (GO:0017144)	3.61067845
136	monocarboxylic acid catabolic process (GO:0072329)	3.60800673
137	xenobiotic metabolic process (GO:0006805)	3.59261297
138	steroid catabolic process (GO:0006706)	3.58262190
139	negative regulation of fatty acid biosynthetic process (GO:0045717)	3.56977126
140	very-low-density lipoprotein particle assembly (GO:0034379)	3.55489706

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	* RXR_22158963_ChIP-Seq_LIVER_Mouse	8.34388486
2	* PPARA_22158963_ChIP-Seq_LIVER_Mouse	7.13875424
3	EGR1_23403033_ChIP-Seq_LIVER_Mouse	6.76663838
4	LXR_22158963_ChIP-Seq_LIVER_Mouse	6.47216083
5	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	5.16707699
6	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	4.84454978
7	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	4.83397863
8	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	4.00189670
9	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	3.85911918
10	TCF7L2_21901280_ChIP-Seq_H4IIE_Rat	2.12168274
11	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	2.11941074
12	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.08268161
13	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	11.7397980
14	* FOXA2_19822575_ChIP-Seq_HepG2_Human	1.62887551
15	CLOCK_20551151_ChIP-Seq_293T_Human	1.60755780
16	* HNF4A_19822575_ChIP-Seq_HepG2_Human	1.46927323
17	HTT_18923047_ChIP-ChIP_STHdh_Human	1.40019880
18	GATA1_22025678_ChIP-Seq_K562_Human	1.36056209
19	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	1.25204710
20	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.17135991
21	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.17007130
22	RXRA_24833708_ChIP-Seq_LIVER_Mouse	1.15143185
23	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.07682070
24	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.06214124
25	SOX2_27498859_Chip-Seq_STOMACH_Mouse	1.03319874
26	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.03312334
27	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.01404968
28	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.00459648
29	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	0.99676312
30	HNFA_21074721_ChIP-Seq_CACO-2_Human	0.98955735
31	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	0.95731394
32	RARG_19884340_ChIP-ChIP_MEFs_Mouse	0.94646879
33	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	0.93731948
34	IRF1_19129219_ChIP-ChIP_H3396_Human	0.93021493
35	PHF8_20622853_ChIP-Seq_HELA_Human	0.92948024
36	GATA4_25053715_ChIP-Seq_YYC3_Human	0.91806171
37	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.91411077
38	ESR1_15608294_ChIP-ChIP_MCF-7_Human	0.86936285
39	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.86462216
40	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	0.86239172
41	NFYA_21822215_ChIP-Seq_K562_Human	0.84769889
42	TP53_18474530_ChIP-ChIP_U2OS_Human	0.84320139
43	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.81373330
44	IRF8_22096565_ChIP-ChIP_GC-B_Human	0.80613996
45	ESR2_21235772_ChIP-Seq_MCF-7_Human	0.80203420
46	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	0.79815845
47	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.79183831
48	KAP1_22055183_ChIP-Seq_ESCs_Mouse	0.77077786
49	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.76726703
50	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	0.76233339
51	SOX2_21211035_ChIP-Seq_LN229_Human	0.74842053
52	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	0.74707993
53	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	0.73359497
54	ER_23166858_ChIP-Seq_MCF-7_Human	0.72748385
55	* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse	0.72438262
56	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.71639037
57	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	0.71009229
58	CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse	0.70305676
59	CBX2_22325352_ChIP-Seq_293T-Rex_Human	0.70296776
60	RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	0.70294821
61	RARA_24833708_ChIP-Seq_LIVER_Mouse	0.70109002
62	ESR1_21235772_ChIP-Seq_MCF-7_Human	0.69931489
63	NR0B1_18358816_ChIP-ChIP_MESCs_Mouse	0.69754669
64	SALL4_18804426_ChIP-ChIP_XEN_Mouse	0.68963874
65	NRF2_20460467_ChIP-Seq_MEFs_Mouse	0.66609354
66	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	0.66609354
67	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.66564369
68	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.66257297
69	ZNF263_19887448_ChIP-Seq_K562_Human	0.66140850
70	CDX2_20551321_ChIP-Seq_CACO-2_Human	0.65797534
71	ETV1_20927104_ChIP-Seq_GIST48_Human	0.64451866
72	RAD21_21589869_ChIP-Seq_MESCs_Mouse	0.63523829
73	IGF1R_20145208_ChIP-Seq_DFB_Human	0.63430708
74	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	0.62726431
75	EGR1_19032775_ChIP-ChIP_M12_Human	0.61969472
76	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	0.61893071
77	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.61737062
78	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.61568845
79	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	0.61229915
80	NFYB_21822215_ChIP-Seq_K562_Human	0.60572270
81	CEBPB_22108803_ChIP-Seq_LS180_Human	0.60156153
82	POU3F2_20337985_ChIP-ChIP_501MEL_Human	0.58928611
83	LXR_22292898_ChIP-Seq_THP-1_Human	0.58874967
84	STAT3_1855785_ChIP-Seq_MESCs_Mouse	0.58085227
85	RARB_24833708_ChIP-Seq_LIVER_Mouse	0.58007326
86	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.56670485
87	FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	0.55962231
88	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	0.55601757
89	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.55420193
90	MYC_19915707_ChIP-ChIP_AK7_Human	0.54872066
91	ERG_20517297_ChIP-Seq_VCAP_Human	0.54272975
92	AR_20517297_ChIP-Seq_VCAP_Human	0.54079803
93	RBPJ_21746931_ChIP-Seq_IB4_Human	0.53850251
94	FOXA1_25552417_ChIP-Seq_VCAP_Human	0.53032494
95	SPI1_20517297_ChIP-Seq_HL60_Human	0.52113017
96	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	0.52027257
97	RAC3_21632823_ChIP-Seq_H3396_Human	0.51732828
98	ESET_19884257_ChIP-Seq_ESCs_Mouse	0.51721225
99	TCF4_18268006_ChIP-ChIP_LS174T_Human	0.51391916
100	STAT1_17558387_ChIP-Seq_HELA_Human	0.51318412
101	CBP_21632823_ChIP-Seq_H3396_Human	0.51002233
102	FOXO3_23340844_ChIP-Seq_DLD1_Human	0.49966566
103	OCT4_21477851_ChIP-Seq_ESCs_Mouse	0.49693318
104	GATA6_25053715_ChIP-Seq_YYC3_Human	0.49163333
105	PPAR_26484153_Chip-Seq_NCI-H1993_Human	0.49153774
106	* EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.49016898
107	NCOR_22424771_ChIP-Seq_293T_Human	0.48714475
108	MYC_19829295_ChIP-Seq_ESCs_Human	0.48676505
109	CBP_20019798_ChIP-Seq_JUKART_Human	0.48368892
110	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.48368892
111	FOXA1_26743006_Chip-Seq_LNCaP-abl_Human	0.47760428
112	PPARG_20887899_ChIP-Seq_3T3-L1_Mouse	0.47389734
113	FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human	0.45556778
114	P53_21459846_ChIP-Seq_SAOS-2_Human	0.45357935
115	TAF2_19829295_ChIP-Seq_ESCs_Human	0.44494197
116	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.44158566
117	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.44061025
118	GATA2_19941826_ChIP-Seq_K562_Human	0.44007167
119	TAF15_26573619_Chip-Seq_HEK293_Human	0.43696431
120	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	0.41857469
121	GATA1_19941826_ChIP-Seq_K562_Human	0.41734052
122	GATA1_19941827_ChIP-Seq_MEL_Mouse	0.41724796
123	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.41543681
124	ESR1_20079471_ChIP-ChIP_T-47D_Human	0.40868821
125	CDX2_22108803_ChIP-Seq_LS180_Human	0.40602827
126	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	0.40359688
127	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.40030684
128	BCAT_22108803_ChIP-Seq_LS180_Human	0.39784071
129	ERG_21242973_ChIP-ChIP_JURKAT_Human	0.39592484
130	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	0.39336827
131	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	0.39297740
132	* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.39118880
133	SOX2_20726797_ChIP-Seq_SW620_Human	0.38284168
134	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	0.38129399
135	STAT3_19079543_ChIP-ChIP_MESCs_Mouse	0.37512840
136	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.37336207
137	CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.37009907
138	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.36745830
139	LUZP1_20508642_ChIP-Seq_ESCs_Mouse	0.36744651

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002139_abnormal_hepatobiliary_system	8.29343064
2	MP0005360_urolithiasis	7.88043656
3	MP0005085_abnormal_gallbladder_physiolo	6.27100632
4	MP0005365_abnormal_bile_salt	6.00598523
5	MP0008875_abnormal_xenobiotic_pharmacok	5.16795549
6	MP0003806_abnormal_nucleotide_metabolis	4.03324571
7	MP0003252_abnormal_bile_duct	4.00629013
8	MP0010329_abnormal_lipoprotein_level	3.39463985
9	MP0005332_abnormal_amino_acid	3.09277529
10	MP0009840_abnormal_foam_cell	3.03072846
11	MP0003195_calcinosis	3.00505646
12	MP0005083_abnormal_biliary_tract	2.81887172
13	MP0001666_abnormal_nutrient_absorption	2.60935402
14	MP0004019_abnormal_vitamin_homeostasis	2.55539520
15	MP0002138_abnormal_hepatobiliary_system	2.31350111
16	MP0003191_abnormal_cellular_cholesterol	2.16452503
17	MP0000609_abnormal_liver_physiology	2.07467811
18	MP0002118_abnormal_lipid_homeostasis	2.04903193
19	MP0005319_abnormal_enzyme/_coenzyme	1.84065860
20	MP0003868_abnormal_feces_composition	1.77765282
21	MP0001764_abnormal_homeostasis	1.65852024
22	MP0005584_abnormal_enzyme/coenzyme_acti	1.62141844
23	MP0005451_abnormal_body_composition	1.59196889
24	MP0009643_abnormal_urine_homeostasis	1.56642655
25	MP0009697_abnormal_copulation	1.38673264
26	MP0003186_abnormal_redox_activity	1.34913092
27	MP0003011_delayed_dark_adaptation	1.21853709
28	MP0005636_abnormal_mineral_homeostasis	1.17723729
29	MP0000598_abnormal_liver_morphology	1.14090187
30	MP0003656_abnormal_erythrocyte_physiolo	1.11473767
31	MP0002132_abnormal_respiratory_system	1.07649508
32	MP0003705_abnormal_hypodermis_morpholog	1.05065419
33	MP0009764_decreased_sensitivity_to	1.04927192
34	MP0005647_abnormal_sex_gland	1.02865783
35	MP0000604_amyloidosis	0.97649260
36	MP0009763_increased_sensitivity_to	0.92856463
37	MP0005084_abnormal_gallbladder_morpholo	0.91394332
38	MP0002254_reproductive_system_inflammat	0.90184324
39	MP0005670_abnormal_white_adipose	0.89162553
40	MP0005187_abnormal_penis_morphology	0.88421293
41	MP0001756_abnormal_urination	0.88163894
42	MP0009642_abnormal_blood_homeostasis	0.88077647
43	MP0002876_abnormal_thyroid_physiology	0.88059545
44	MP0006036_abnormal_mitochondrial_physio	0.87955199
45	MP0001915_intracranial_hemorrhage	0.86582996
46	MP0008469_abnormal_protein_level	0.86385926
47	MP0004043_abnormal_pH_regulation	0.83428064
48	MP0005408_hypopigmentation	0.81058444
49	MP0005376_homeostasis/metabolism_phenot	0.76813682
50	MP0002078_abnormal_glucose_homeostasis	0.76663616
51	MP0010368_abnormal_lymphatic_system	0.76204094
52	MP0009765_abnormal_xenobiotic_induced	0.75657108
53	MP0002136_abnormal_kidney_physiology	0.74651371
54	MP0005535_abnormal_body_temperature	0.72500010
55	MP0005220_abnormal_exocrine_pancreas	0.71818296
56	MP0002282_abnormal_trachea_morphology	0.71225196
57	MP0001661_extended_life_span	0.69508687
58	MP0002971_abnormal_brown_adipose	0.69101531
59	MP0005334_abnormal_fat_pad	0.64855122
60	MP0005266_abnormal_metabolism	0.63385056
61	MP0003879_abnormal_hair_cell	0.63252788
62	MP0004130_abnormal_muscle_cell	0.63051343
63	MP0003329_amyloid_beta_deposits	0.60337906
64	MP0003690_abnormal_glial_cell	0.60011784
65	MP0009053_abnormal_anal_canal	0.59919734
66	MP0006035_abnormal_mitochondrial_morpho	0.59656765
67	MP0002928_abnormal_bile_duct	0.58855277
68	MP0001765_abnormal_ion_homeostasis	0.54882554
69	MP0003638_abnormal_response/metabolism_	0.52577801
70	MP0002249_abnormal_larynx_morphology	0.51251741
71	MP0005395_other_phenotype	0.50822302
72	MP0005448_abnormal_energy_balance	0.50184690
73	MP0000639_abnormal_adrenal_gland	0.48711013
74	MP0005023_abnormal_wound_healing	0.48579294
75	MP0005666_abnormal_adipose_tissue	0.46659585
76	MP0000230_abnormal_systemic_arterial	0.44023166
77	MP0008874_decreased_physiological_sensi	0.43659353
78	MP0005464_abnormal_platelet_physiology	0.42564360
79	MP0003953_abnormal_hormone_level	0.42242655
80	MP0005058_abnormal_lysosome_morphology	0.41697079
81	MP0002822_catalepsy	0.41635673
82	MP0002168_other_aberrant_phenotype	0.41405512
83	MP0008873_increased_physiological_sensi	0.40991467
84	MP0003718_maternal_effect	0.40156529
85	MP0003724_increased_susceptibility_to	0.39313063
86	MP0003959_abnormal_lean_body	0.39223812
87	MP0008872_abnormal_physiological_respon	0.38139754
88	MP0009785_altered_susceptibility_to	0.38116600
89	MP0004782_abnormal_surfactant_physiolog	0.37209808
90	MP0002796_impaired_skin_barrier	0.36951363
91	MP0009672_abnormal_birth_weight	0.36394830
92	MP0003075_altered_response_to	0.36206912
93	MP0005166_decreased_susceptibility_to	0.35937164
94	MP0002837_dystrophic_cardiac_calcinosis	0.35701264
95	MP0002332_abnormal_exercise_endurance	0.34067046
96	MP0003436_decreased_susceptibility_to	0.31627272
97	MP0009115_abnormal_fat_cell	0.31463913
98	MP0004883_abnormal_blood_vessel	0.31398591
99	MP0005164_abnormal_response_to	0.31073233
100	MP0005248_abnormal_Harderian_gland	0.30909228
101	MP0002135_abnormal_kidney_morphology	0.30780080
102	MP0000538_abnormal_urinary_bladder	0.30664403
103	MP0005197_abnormal_uvea_morphology	0.30481836
104	MP0009384_cardiac_valve_regurgitation	0.30393183
105	MP0000467_abnormal_esophagus_morphology	0.30244277
106	MP0004264_abnormal_extraembryonic_tissu	0.29424678
107	MP0006082_CNS_inflammation	0.28617507
108	MP0003300_gastrointestinal_ulcer	0.28166239
109	MP0000579_abnormal_nail_morphology	0.27598204
110	MP0001845_abnormal_inflammatory_respons	0.27165573
111	MP0004381_abnormal_hair_follicle	0.26492705
112	MP0000249_abnormal_blood_vessel	0.26400179
113	MP0002970_abnormal_white_adipose	0.26334881
114	MP0001853_heart_inflammation	0.25239198
115	MP0004142_abnormal_muscle_tone	0.19930555
116	MP0001851_eye_inflammation	0.19508406
117	MP0000566_synostosis	0.19299399
118	MP0001881_abnormal_mammary_gland	0.18776472
119	MP0002128_abnormal_blood_circulation	0.17681039
120	MP0004272_abnormal_basement_membrane	0.15693214
121	MP0003633_abnormal_nervous_system	0.13174803
122	MP0003632_abnormal_nervous_system	0.11262027

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of aromatic amino acid family metabolism (HP:0004338)	7.14576937
2	Intrahepatic cholestasis (HP:0001406)	6.98614198
3	Deep venous thrombosis (HP:0002625)	6.77980749
4	Abnormality of monocarboxylic acid metabolism (HP:0010996)	6.37497864
5	Xanthomatosis (HP:0000991)	6.10588129
6	Hypobetalipoproteinemia (HP:0003563)	6.04174961
7	Prolonged partial thromboplastin time (HP:0003645)	5.91455655
8	Hyperlipoproteinemia (HP:0010980)	5.12767825
9	Complement deficiency (HP:0004431)	4.74815127
10	Abnormality of glutamine family amino acid metabolism (HP:0010902)	4.68527863
11	Hyperammonemia (HP:0001987)	4.67138764
12	Hyperglycinemia (HP:0002154)	4.49418840
13	Ketosis (HP:0001946)	4.49412512
14	Hypolipoproteinemia (HP:0010981)	4.47603270
15	Joint hemorrhage (HP:0005261)	4.42079625
16	Hyperglycinuria (HP:0003108)	4.41701881
17	Abnormality of aspartate family amino acid metabolism (HP:0010899)	4.36464594
18	Epidermoid cyst (HP:0200040)	4.32985817
19	Abnormality of sulfur amino acid metabolism (HP:0004339)	4.30919162
20	Abnormality of serine family amino acid metabolism (HP:0010894)	4.25912198
21	Abnormality of glycine metabolism (HP:0010895)	4.25912198
22	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	4.08905888
23	Abnormality of methionine metabolism (HP:0010901)	4.08368344
24	Abnormality of the common coagulation pathway (HP:0010990)	4.02826064
25	Fat malabsorption (HP:0002630)	3.99002900
26	Hypoalphalipoproteinemia (HP:0003233)	3.86171431
27	Hypoglycemic coma (HP:0001325)	3.77623289
28	Abnormality of pyrimidine metabolism (HP:0004353)	3.74236042
29	Nephritis (HP:0000123)	3.71596428
30	Conjugated hyperbilirubinemia (HP:0002908)	3.63712780
31	Abnormality of fatty-acid metabolism (HP:0004359)	3.58718777
32	Hypercholesterolemia (HP:0003124)	3.43618725
33	Abnormality of complement system (HP:0005339)	3.42442768
34	Abnormality of nucleobase metabolism (HP:0010932)	3.40857568
35	Abnormality of the intrinsic pathway (HP:0010989)	3.40719137
36	Ketoacidosis (HP:0001993)	3.39779479
37	Gout (HP:0001997)	3.39081179
38	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	3.33118093
39	Delayed CNS myelination (HP:0002188)	3.31332398
40	Hyperbilirubinemia (HP:0002904)	3.25666525
41	Abnormality of purine metabolism (HP:0004352)	3.24168331
42	Abnormality of serum amino acid levels (HP:0003112)	3.11575934
43	Hepatocellular carcinoma (HP:0001402)	2.97976174
44	Metabolic acidosis (HP:0001942)	2.96768711
45	Steatorrhea (HP:0002570)	2.93379761
46	Reduced antithrombin III activity (HP:0001976)	2.85658464
47	Vascular calcification (HP:0004934)	2.83667242
48	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.78399464
49	Dicarboxylic aciduria (HP:0003215)	2.78399464
50	Osteomalacia (HP:0002749)	2.77903022
51	Lethargy (HP:0001254)	2.73924268
52	Myocardial infarction (HP:0001658)	2.68133954
53	Fair hair (HP:0002286)	2.64982418
54	Skin nodule (HP:0200036)	2.63479166
55	Spontaneous abortion (HP:0005268)	2.62274585
56	Hypochromic microcytic anemia (HP:0004840)	2.58610206
57	Generalized aminoaciduria (HP:0002909)	2.56870605
58	Neonatal hypoglycemia (HP:0001998)	2.56254207
59	Malnutrition (HP:0004395)	2.55700158
60	Spastic diplegia (HP:0001264)	2.51562892
61	Cardiovascular calcification (HP:0011915)	2.51349392
62	Proximal tubulopathy (HP:0000114)	2.50387253
63	Systemic lupus erythematosus (HP:0002725)	2.49550701
64	Irritability (HP:0000737)	2.46332519
65	Acanthocytosis (HP:0001927)	2.45997493
66	Alkalosis (HP:0001948)	2.45966753
67	Cerebral edema (HP:0002181)	2.42779933
68	Pulmonary embolism (HP:0002204)	2.41365098
69	Purpura (HP:0000979)	2.41155173
70	Neonatal onset (HP:0003623)	2.40829354
71	Increased purine levels (HP:0004368)	2.36881220
72	Hyperuricemia (HP:0002149)	2.36881220
73	Enlarged kidneys (HP:0000105)	2.33913975
74	Hypoglycemic seizures (HP:0002173)	2.33463365
75	Abnormal gallbladder morphology (HP:0012437)	2.29775074
76	Sensorimotor neuropathy (HP:0007141)	2.29328407
77	Hydroxyprolinuria (HP:0003080)	2.27582877
78	Abnormality of proline metabolism (HP:0010907)	2.27582877
79	Vomiting (HP:0002013)	2.27506483
80	Mitral stenosis (HP:0001718)	2.25343696
81	Cholelithiasis (HP:0001081)	2.24859622
82	Cholecystitis (HP:0001082)	2.24733132
83	Abnormal gallbladder physiology (HP:0012438)	2.24733132
84	Hyperphosphaturia (HP:0003109)	2.24228180
85	Rickets (HP:0002748)	2.23348871
86	Late onset (HP:0003584)	2.21280701
87	Glycosuria (HP:0003076)	2.19807286
88	Abnormality of urine glucose concentration (HP:0011016)	2.19807286
89	Glomerulonephritis (HP:0000099)	2.19595692
90	Pancreatitis (HP:0001733)	2.17766636
91	Esophageal varix (HP:0002040)	2.10515386
92	Elevated alkaline phosphatase (HP:0003155)	2.09881081
93	Brushfield spots (HP:0001088)	2.05029843
94	Abnormal enzyme/coenzyme activity (HP:0012379)	2.03677804
95	Amyloidosis (HP:0011034)	1.99542149
96	Opisthotonus (HP:0002179)	1.98787501
97	Recurrent gram-negative bacterial infections (HP:0005420)	1.97528014
98	Menorrhagia (HP:0000132)	1.95254912
99	Bile duct proliferation (HP:0001408)	1.95180130
100	Abnormal biliary tract physiology (HP:0012439)	1.95180130
101	Hypophosphatemic rickets (HP:0004912)	1.93152493
102	Thrombophlebitis (HP:0004418)	1.92477127
103	Abnormality of the gallbladder (HP:0005264)	1.91307732
104	Abnormal cartilage morphology (HP:0002763)	1.89896278
105	Hyperinsulinemic hypoglycemia (HP:0000825)	1.89274380
106	Poikilocytosis (HP:0004447)	1.88560856
107	Arthropathy (HP:0003040)	1.88289346
108	Abnormality of alkaline phosphatase activity (HP:0004379)	1.88179787
109	Bifid scrotum (HP:0000048)	1.87281572
110	Renal cortical cysts (HP:0000803)	1.86534024
111	Gingival bleeding (HP:0000225)	1.86334573
112	Hemorrhage of the eye (HP:0011885)	1.84924522
113	Increased mean platelet volume (HP:0011877)	1.84578361
114	Confusion (HP:0001289)	1.84029682
115	Generalized hypopigmentation of hair (HP:0011358)	1.82937041
116	Abnormality of vitamin metabolism (HP:0100508)	1.81332894
117	Gangrene (HP:0100758)	1.78785582
118	Abnormal urine phosphate concentration (HP:0012599)	1.78520411
119	Atrioventricular block (HP:0001678)	1.76164738
120	Abnormality of the Achilles tendon (HP:0005109)	1.75723111
121	Abnormality of iron homeostasis (HP:0011031)	1.71182514
122	Joint swelling (HP:0001386)	1.70760187
123	Increased serum ferritin (HP:0003281)	1.66389746
124	Abnormal platelet volume (HP:0011876)	1.65891794
125	Reticulocytosis (HP:0001923)	1.59705959
126	Cerebral palsy (HP:0100021)	1.58269017
127	Blue irides (HP:0000635)	1.55013191
128	Abnormality of transition element cation homeostasis (HP:0011030)	1.54861960

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	BCKDK	7.23908020
2	FGFR4	4.30554708
3	SIK1	4.12240756
4	ERN1	3.94345032
5	INSRR	2.92978947
6	ERBB4	2.71770224
7	TAOK3	2.65781180
8	MST1R	2.40146371
9	MAP2K4	2.20990348
10	PKN2	2.05327086
11	MAP3K12	2.00976124
12	MAPK11	1.86596277
13	WNK4	1.81749022
14	PIK3CA	1.77395786
15	WNK3	1.75510633
16	PIK3CG	1.73236867
17	FLT3	1.67929611
18	LATS1	1.67158436
19	NTRK3	1.66304011
20	TRIB3	1.57468927
21	FRK	1.56557364
22	PRPF4B	1.55617463
23	STK38L	1.53225224
24	TYK2	1.50530151
25	ABL2	1.49540077
26	MYLK	1.47375285
27	PTK6	1.45120372
28	OXSR1	1.40629343
29	DAPK2	1.32620340
30	MAP3K7	1.32150992
31	NEK9	1.32016833
32	PINK1	1.29828042
33	GRK6	1.23801100
34	ARAF	1.23713406
35	FGFR2	1.23000354
36	TNK2	1.19557450
37	KDR	1.16893337
38	PRKAA2	1.16680081
39	JAK2	1.12066249
40	MAP3K3	1.04796037
41	MAP3K10	1.04175285
42	MAP2K3	1.02345590
43	MAP3K14	1.00763506
44	FER	0.99431958
45	CASK	0.95324030
46	PRKCZ	0.93151451
47	ERBB2	0.92859065
48	MUSK	0.92441344
49	EPHB1	0.92106183
50	MAPK4	0.91909794
51	MAP3K1	0.91907996
52	TBK1	0.91410695
53	EIF2AK1	0.90521066
54	SCYL2	0.89144107
55	MET	0.89076289
56	PRKACA	0.88910613
57	KSR2	0.87543314
58	JAK1	0.87523346
59	MAP3K2	0.87222460
60	SGK3	0.86987285
61	NLK	0.85174323
62	PRKG1	0.83588047
63	PDK4	0.82620720
64	PDK3	0.82620720
65	MAP3K9	0.82270377
66	GSK3A	0.80734962
67	TIE1	0.80575087
68	MAPK15	0.79076208
69	DYRK1B	0.78093513
70	SGK494	0.76775084
71	SGK223	0.76775084
72	PRKAA1	0.75497921
73	CSNK1D	0.75292292
74	PRKACG	0.73765386
75	MAPK12	0.72818423
76	BCR	0.72108301
77	SGK2	0.68993535
78	MAP3K11	0.68688714
79	CDK6	0.68208140
80	MAP2K6	0.66497446
81	PTK2	0.64567105
82	CSK	0.64207446
83	RIPK1	0.64151508
84	IRAK3	0.64121481
85	CAMKK2	0.61608293
86	CAMK2G	0.61480809
87	TGFBR2	0.59464580
88	PDPK1	0.58897803
89	PRKCB	0.55076022
90	RPS6KA3	0.54834551
91	EPHA3	0.54271453
92	CAMK1D	0.53310839
93	PRKACB	0.50417859
94	EPHA4	0.49374551
95	PRKCQ	0.48467648
96	FGFR3	0.48102132
97	MAPK7	0.48092774
98	CAMKK1	0.46274758
99	CSNK1G1	0.44202352
100	CSF1R	0.43119799
101	NEK1	0.42406920
102	MAP3K5	0.41622514
103	IGF1R	0.40862762
104	SGK1	0.40643302
105	IKBKE	0.40173530
106	SRC	0.39733833
107	CSNK1E	0.39488086
108	PDK2	0.39247406
109	GRK1	0.38621202
110	PDK1	0.38197581
111	MAP3K6	0.37029795
112	STK39	0.36196839
113	MAP2K1	0.35950188
114	PRKCG	0.35506980
115	STK38	0.35096271
116	CSNK2A1	0.33858432
117	MAP3K13	0.33769707
118	RET	0.33318665
119	MTOR	0.32791441
120	ICK	0.32161707
121	TAOK2	0.31370405
122	CDK4	0.31149378
123	IRAK2	0.30933432
124	RAF1	0.30759753
125	AKT3	0.29859378
126	EGFR	0.28797827
127	ZAP70	0.28117906
128	PRKCA	0.27597686
129	PAK3	0.26506948
130	PBK	0.26191038
131	CAMK4	0.25789841
132	PKN1	0.25714276
133	IRAK1	0.25393551

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Primary bile acid biosynthesis_Homo sapiens_hsa00120	4.28740525
2	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	3.46368524
3	Nitrogen metabolism_Homo sapiens_hsa00910	3.41171014
4	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	3.31114812
5	Arginine biosynthesis_Homo sapiens_hsa00220	2.94527441
6	Tryptophan metabolism_Homo sapiens_hsa00380	2.71730277
7	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	2.70571071
8	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	2.69520443
9	Fatty acid degradation_Homo sapiens_hsa00071	2.56308850
10	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	2.52056620
11	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.51016369
12	Complement and coagulation cascades_Homo sapiens_hsa04610	2.45980273
13	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	2.40136256
14	Butanoate metabolism_Homo sapiens_hsa00650	2.38572012
15	Peroxisome_Homo sapiens_hsa04146	2.18921128
16	Propanoate metabolism_Homo sapiens_hsa00640	2.08850944
17	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	2.06728729
18	PPAR signaling pathway_Homo sapiens_hsa03320	1.88132377
19	Histidine metabolism_Homo sapiens_hsa00340	1.87421051
20	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.86381307
21	Fatty acid metabolism_Homo sapiens_hsa01212	1.85994963
22	Chemical carcinogenesis_Homo sapiens_hsa05204	1.85426201
23	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.83210088
24	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.82481189
25	beta-Alanine metabolism_Homo sapiens_hsa00410	1.79772032
26	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.71724669
27	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.70760714
28	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.69773272
29	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.64719661
30	Caffeine metabolism_Homo sapiens_hsa00232	1.64662087
31	Retinol metabolism_Homo sapiens_hsa00830	1.64023167
32	Bile secretion_Homo sapiens_hsa04976	1.56881451
33	Selenocompound metabolism_Homo sapiens_hsa00450	1.56455107
34	Phenylalanine metabolism_Homo sapiens_hsa00360	1.52560310
35	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.51723005
36	Sulfur metabolism_Homo sapiens_hsa00920	1.41400684
37	* Pyruvate metabolism_Homo sapiens_hsa00620	1.35188649
38	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.34825527
39	Tyrosine metabolism_Homo sapiens_hsa00350	1.33996588
40	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.33662344
41	Fatty acid elongation_Homo sapiens_hsa00062	1.31099310
42	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.28954529
43	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.28317303
44	Folate biosynthesis_Homo sapiens_hsa00790	1.22201682
45	Carbon metabolism_Homo sapiens_hsa01200	1.20134346
46	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.19764653
47	ABC transporters_Homo sapiens_hsa02010	1.16195979
48	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.15498034
49	Fat digestion and absorption_Homo sapiens_hsa04975	1.14235642
50	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.13502701
51	Steroid biosynthesis_Homo sapiens_hsa00100	1.10918341
52	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.06364795
53	Arginine and proline metabolism_Homo sapiens_hsa00330	1.03826894
54	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.98665732
55	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.91976787
56	Lysine degradation_Homo sapiens_hsa00310	0.89714506
57	Sulfur relay system_Homo sapiens_hsa04122	0.86743583
58	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.84843452
59	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.80612831
60	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.76549228
61	Glutathione metabolism_Homo sapiens_hsa00480	0.75772692
62	Glycerolipid metabolism_Homo sapiens_hsa00561	0.73983993
63	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.68906503
64	One carbon pool by folate_Homo sapiens_hsa00670	0.66571121
65	Pentose phosphate pathway_Homo sapiens_hsa00030	0.58845006
66	Metabolic pathways_Homo sapiens_hsa01100	0.47953714
67	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.44931291
68	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.34386327
69	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.31875075
70	Galactose metabolism_Homo sapiens_hsa00052	0.28449257
71	Pertussis_Homo sapiens_hsa05133	0.26962488
72	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.24875443
73	Prion diseases_Homo sapiens_hsa05020	0.22898143
74	Insulin resistance_Homo sapiens_hsa04931	0.22212346
75	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.21373131
76	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.19697220
77	Linoleic acid metabolism_Homo sapiens_hsa00591	0.16298281
78	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.13178528
79	Glucagon signaling pathway_Homo sapiens_hsa04922	0.09214519
80	AMPK signaling pathway_Homo sapiens_hsa04152	0.02132335
81	Serotonergic synapse_Homo sapiens_hsa04726	0.00902859
82	N-Glycan biosynthesis_Homo sapiens_hsa00510	-0.2682509
83	Vascular smooth muscle contraction_Homo sapiens_hsa04270	-0.2545848
84	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	-0.2398136
85	Sphingolipid metabolism_Homo sapiens_hsa00600	-0.2368383
86	Lysosome_Homo sapiens_hsa04142	-0.2294307
87	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	-0.2294118
88	Systemic lupus erythematosus_Homo sapiens_hsa05322	-0.2273513
89	Circadian rhythm_Homo sapiens_hsa04710	-0.2208550
90	African trypanosomiasis_Homo sapiens_hsa05143	-0.2071070
91	Type II diabetes mellitus_Homo sapiens_hsa04930	-0.2045842
92	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	-0.1926032
93	Central carbon metabolism in cancer_Homo sapiens_hsa05230	-0.1790170
94	Hepatitis C_Homo sapiens_hsa05160	-0.1757732
95	Regulation of autophagy_Homo sapiens_hsa04140	-0.1354035
96	Protein digestion and absorption_Homo sapiens_hsa04974	-0.1327316
97	Thyroid hormone synthesis_Homo sapiens_hsa04918	-0.1286269
98	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	-0.1270423
99	Insulin signaling pathway_Homo sapiens_hsa04910	-0.1209979
100	Mineral absorption_Homo sapiens_hsa04978	-0.1110623
101	Arachidonic acid metabolism_Homo sapiens_hsa00590	-0.1089443
102	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	-0.0973498
103	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	-0.0939184
104	Ovarian steroidogenesis_Homo sapiens_hsa04913	-0.0918749
105	Glycosaminoglycan degradation_Homo sapiens_hsa00531	-0.0833965
106	Other glycan degradation_Homo sapiens_hsa00511	-0.0565235
107	Amoebiasis_Homo sapiens_hsa05146	-0.0500147
108	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	-0.0385714
109	Renin-angiotensin system_Homo sapiens_hsa04614	-0.0286156

ACOT12

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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