ACOT6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium movement (GO:0003341)6.99716423
2response to muscle activity (GO:0014850)6.58318135
3axoneme assembly (GO:0035082)5.74984723
4glyoxylate metabolic process (GO:0046487)5.58404741
5axonemal dynein complex assembly (GO:0070286)5.48116997
6positive regulation of synaptic transmission, dopaminergic (GO:0032226)5.45446540
7central nervous system myelination (GO:0022010)5.41803630
8axon ensheathment in central nervous system (GO:0032291)5.41803630
9regulation of oxidative phosphorylation (GO:0002082)5.40215548
10ventricular system development (GO:0021591)5.16448918
11AMP metabolic process (GO:0046033)5.09136849
12epithelial cilium movement (GO:0003351)4.80922397
13cilium or flagellum-dependent cell motility (GO:0001539)4.76702551
14GTP biosynthetic process (GO:0006183)4.76114815
15ADP metabolic process (GO:0046031)4.75812787
16activation of protein kinase B activity (GO:0032148)4.67674875
17serine family amino acid catabolic process (GO:0009071)4.67442276
18cellular response to zinc ion (GO:0071294)4.61030868
19nucleoside diphosphate phosphorylation (GO:0006165)4.48904400
20muscle filament sliding (GO:0030049)4.33672745
21actin-myosin filament sliding (GO:0033275)4.33672745
22coenzyme catabolic process (GO:0009109)4.25617909
23positive regulation of catecholamine secretion (GO:0033605)4.19490446
24UTP metabolic process (GO:0046051)4.08304073
25UTP biosynthetic process (GO:0006228)4.04654938
26epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.91531918
27cellular response to cadmium ion (GO:0071276)3.85386611
28glycine metabolic process (GO:0006544)3.79337572
29muscle cell cellular homeostasis (GO:0046716)3.70201710
30myofibril assembly (GO:0030239)3.63798346
31regulation of cellular respiration (GO:0043457)3.59151998
32regulation of oxidative stress-induced neuron death (GO:1903203)3.57183121
33CTP metabolic process (GO:0046036)3.50287358
34CTP biosynthetic process (GO:0006241)3.50287358
35polyketide metabolic process (GO:0030638)3.49667317
36doxorubicin metabolic process (GO:0044598)3.49667317
37daunorubicin metabolic process (GO:0044597)3.49667317
38actin-mediated cell contraction (GO:0070252)3.48689131
39regulation of autophagic vacuole assembly (GO:2000785)3.48247626
40fructose metabolic process (GO:0006000)3.40793355
41uronic acid metabolic process (GO:0006063)3.30210143
42glucuronate metabolic process (GO:0019585)3.30210143
43epoxygenase P450 pathway (GO:0019373)3.27087203
44cellular glucuronidation (GO:0052695)3.25664839
45xenobiotic catabolic process (GO:0042178)3.20327487
46establishment of protein localization to mitochondrial membrane (GO:0090151)3.16090121
47pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)3.15157733
48peptidyl-glutamic acid carboxylation (GO:0017187)3.14788413
49protein carboxylation (GO:0018214)3.14788413
50left/right axis specification (GO:0070986)3.13069895
51phenylpropanoid metabolic process (GO:0009698)3.13056119
52glycogen metabolic process (GO:0005977)3.11341368
53aminoglycoside antibiotic metabolic process (GO:0030647)3.10088740
54negative regulation of response to reactive oxygen species (GO:1901032)3.09647776
55pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.06271945
56ether lipid metabolic process (GO:0046485)3.05911234
57ribosome assembly (GO:0042255)3.05055864
58nerve growth factor signaling pathway (GO:0038180)3.05045610
59negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.04881465
60sarcomere organization (GO:0045214)3.03737329
61glucan metabolic process (GO:0044042)3.03520288
62cellular glucan metabolic process (GO:0006073)3.03520288
63carnitine shuttle (GO:0006853)3.03192218
64short-chain fatty acid metabolic process (GO:0046459)3.03038323
65negative regulation of hydrogen peroxide-induced cell death (GO:1903206)3.02390087
66rRNA modification (GO:0000154)3.00139001
67NADH metabolic process (GO:0006734)2.98303868
68response to mercury ion (GO:0046689)2.97822714
69TOR signaling (GO:0031929)2.96117435
70amino-acid betaine metabolic process (GO:0006577)2.95311434
71omega-hydroxylase P450 pathway (GO:0097267)2.94690139
72intraciliary transport (GO:0042073)2.93279374
73serine family amino acid metabolic process (GO:0009069)2.93240627
74ensheathment of neurons (GO:0007272)2.92858227
75axon ensheathment (GO:0008366)2.92858227
76myelination (GO:0042552)2.92177299
77L-fucose catabolic process (GO:0042355)2.92130623
78fucose catabolic process (GO:0019317)2.92130623
79L-fucose metabolic process (GO:0042354)2.92130623
80DNA double-strand break processing (GO:0000729)2.91864558
81L-methionine salvage (GO:0071267)2.90937337
82L-methionine biosynthetic process (GO:0071265)2.90937337
83amino acid salvage (GO:0043102)2.90937337
84nucleoside diphosphate biosynthetic process (GO:0009133)2.89847004
85carnitine transport (GO:0015879)2.89311567
86amino-acid betaine transport (GO:0015838)2.89311567
87uterus development (GO:0060065)2.88447466
88cofactor catabolic process (GO:0051187)2.88320771
89regulation of fibrinolysis (GO:0051917)2.88088054
90skeletal muscle contraction (GO:0003009)2.87775895
91microtubule bundle formation (GO:0001578)2.87633521
92quinone metabolic process (GO:1901661)2.86192848
93regulation of skeletal muscle contraction (GO:0014819)2.83274527
94urea metabolic process (GO:0019627)2.83084045
95creatine metabolic process (GO:0006600)2.81724351
96myelin maintenance (GO:0043217)2.81186667
97fatty acid transmembrane transport (GO:1902001)2.78513006
98heme transport (GO:0015886)2.77793834
99oligodendrocyte differentiation (GO:0048709)2.77760441
100import into cell (GO:0098657)2.77256588
101cilium morphogenesis (GO:0060271)2.74259462
102water-soluble vitamin biosynthetic process (GO:0042364)2.72154847
103bile acid biosynthetic process (GO:0006699)2.71870169
104nonribosomal peptide biosynthetic process (GO:0019184)2.71774734
105regulation of phosphoprotein phosphatase activity (GO:0043666)2.70492985
106oxidative demethylation (GO:0070989)2.69867766
107cysteine metabolic process (GO:0006534)2.69691531
108regulation of vacuole organization (GO:0044088)2.69517870
109eye photoreceptor cell differentiation (GO:0001754)2.67946771
110photoreceptor cell differentiation (GO:0046530)2.67946771
111glycogen catabolic process (GO:0005980)2.67175335
112branched-chain amino acid catabolic process (GO:0009083)2.66560377
113fatty acid elongation (GO:0030497)2.66314390
114peptidyl-histidine modification (GO:0018202)2.66119014
115negative regulation of striated muscle cell apoptotic process (GO:0010664)2.66014755
116regulation of glucose import in response to insulin stimulus (GO:2001273)2.65465618
117alpha-amino acid catabolic process (GO:1901606)2.64322860
118tricarboxylic acid cycle (GO:0006099)2.63527435
119L-amino acid import (GO:0043092)2.63482826
120drug catabolic process (GO:0042737)2.63446806
121carnitine transmembrane transport (GO:1902603)2.63289984
122quaternary ammonium group transport (GO:0015697)2.62597715
123fatty acid homeostasis (GO:0055089)2.62435322
124glycogen biosynthetic process (GO:0005978)2.61373059
125glucan biosynthetic process (GO:0009250)2.61373059
126mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.60450934
127nucleotide phosphorylation (GO:0046939)2.59715307
128positive regulation of glycolytic process (GO:0045821)2.59590295
129androgen biosynthetic process (GO:0006702)2.59093130
130mitochondrion morphogenesis (GO:0070584)2.58409966
131cerebral cortex radially oriented cell migration (GO:0021799)2.58011457
132positive regulation of cellular response to insulin stimulus (GO:1900078)2.57861397
133regulation of hydrogen peroxide-induced cell death (GO:1903205)2.57503785
134guanosine-containing compound biosynthetic process (GO:1901070)2.56949956
135carnitine metabolic process (GO:0009437)2.56905783
136cytolysis (GO:0019835)2.56208612
137very long-chain fatty acid metabolic process (GO:0000038)2.56064318
138skeletal muscle fiber development (GO:0048741)2.55484848
139sarcoplasmic reticulum calcium ion transport (GO:0070296)2.54357395
140negative regulation of neurotransmitter secretion (GO:0046929)2.52377813
141opsonization (GO:0008228)2.51557145
142progesterone metabolic process (GO:0042448)2.51272019
143response to methylmercury (GO:0051597)2.49456098
144regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.47480903
145positive regulation of respiratory burst (GO:0060267)2.47359847
146regulation of acyl-CoA biosynthetic process (GO:0050812)2.47233282
147neurotransmitter uptake (GO:0001504)2.45598825
148erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.44579617
149L-phenylalanine catabolic process (GO:0006559)2.44579617
150L-serine transport (GO:0015825)2.44342641
151L-phenylalanine metabolic process (GO:0006558)2.44069446
152erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.44069446
153regulation of cholesterol esterification (GO:0010872)2.43971680
154negative regulation of neurotransmitter transport (GO:0051589)2.41254246
155drug transmembrane transport (GO:0006855)2.40511642
156succinate metabolic process (GO:0006105)2.40001315
157thioester biosynthetic process (GO:0035384)2.38952693
158acyl-CoA biosynthetic process (GO:0071616)2.38952693
159motile cilium assembly (GO:0044458)2.35910104
160negative regulation of astrocyte differentiation (GO:0048712)2.33779434
161cilium organization (GO:0044782)2.33535860
162fucose metabolic process (GO:0006004)2.32133407
163long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.30521549
164peptide biosynthetic process (GO:0043043)2.30389091
165protein palmitoylation (GO:0018345)2.28911253
166fatty-acyl-CoA biosynthetic process (GO:0046949)2.28564565
167positive regulation of cellular amine metabolic process (GO:0033240)2.28491802
168presynaptic membrane assembly (GO:0097105)2.27829872
169fatty-acyl-CoA metabolic process (GO:0035337)2.27313005
170cellular ketone body metabolic process (GO:0046950)2.23404714
171acetyl-CoA metabolic process (GO:0006084)2.23249778
172C21-steroid hormone biosynthetic process (GO:0006700)2.22966397
173nucleoside diphosphate metabolic process (GO:0009132)2.21550383
174aspartate family amino acid catabolic process (GO:0009068)2.19158346
175positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.18176641
176neuron remodeling (GO:0016322)2.18145481
177regulation of pigment cell differentiation (GO:0050932)2.17241567
178pyrimidine ribonucleotide metabolic process (GO:0009218)2.16544447
179toxin transport (GO:1901998)2.15349515
180pyrimidine-containing compound transmembrane transport (GO:0072531)2.14670849
181neurotransmitter catabolic process (GO:0042135)2.14096759
182cilium assembly (GO:0042384)2.13280885
183asymmetric protein localization (GO:0008105)2.13002295
184fatty acid beta-oxidation (GO:0006635)2.12498804
185fatty acid catabolic process (GO:0009062)2.11865012
186pyrimidine ribonucleoside biosynthetic process (GO:0046132)2.11303018
187embryonic retina morphogenesis in camera-type eye (GO:0060059)2.10155557
188regulation of coenzyme metabolic process (GO:0051196)2.09133980
189regulation of cofactor metabolic process (GO:0051193)2.09133980
190oxygen transport (GO:0015671)2.09039567
191positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.08945135
192purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.08021236
193pyrimidine ribonucleotide biosynthetic process (GO:0009220)2.06951061
194purine nucleoside triphosphate biosynthetic process (GO:0009145)2.06927199

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.30862716
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.47444567
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.23552878
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.15292792
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.70376444
6GBX2_23144817_ChIP-Seq_PC3_Human3.08419531
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.84477185
8AR_21572438_ChIP-Seq_LNCaP_Human2.82727832
9EGR1_23403033_ChIP-Seq_LIVER_Mouse2.74016013
10GABP_17652178_ChIP-ChIP_JURKAT_Human2.46963683
11CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.35450461
12SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.27660399
13ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.15774004
14JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.11152565
15SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.09747280
16PPARA_22158963_ChIP-Seq_LIVER_Mouse2.06917258
17JARID2_20064375_ChIP-Seq_MESCs_Mouse2.03265953
18CDX2_19796622_ChIP-Seq_MESCs_Mouse2.01389731
19* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.97222470
20PIAS1_25552417_ChIP-Seq_VCAP_Human1.97129392
21SRF_21415370_ChIP-Seq_HL-1_Mouse1.96396421
22TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.87086158
23EZH2_18974828_ChIP-Seq_MESCs_Mouse1.86386693
24RNF2_18974828_ChIP-Seq_MESCs_Mouse1.86386693
25EZH2_22144423_ChIP-Seq_EOC_Human1.85758333
26ETS1_20019798_ChIP-Seq_JURKAT_Human1.82646607
27SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.81607365
28* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.80530884
29SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.78582513
30CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.78205941
31DROSHA_22980978_ChIP-Seq_HELA_Human1.77283765
32BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.76968984
33EST1_17652178_ChIP-ChIP_JURKAT_Human1.76301519
34SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.74683347
35EZH2_27304074_Chip-Seq_ESCs_Mouse1.73148177
36ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.70385909
37EZH2_27294783_Chip-Seq_ESCs_Mouse1.69983502
38SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.68538445
39PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.66818394
40LXR_22158963_ChIP-Seq_LIVER_Mouse1.66755295
41JARID2_20075857_ChIP-Seq_MESCs_Mouse1.64326917
42OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.61149748
43* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.59303443
44NR3C1_21868756_ChIP-Seq_MCF10A_Human1.51535640
45EOMES_21245162_ChIP-Seq_HESCs_Human1.51527087
46ER_23166858_ChIP-Seq_MCF-7_Human1.49416790
47ELK1_19687146_ChIP-ChIP_HELA_Human1.47674419
48ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.47023015
49ESR1_20079471_ChIP-ChIP_T-47D_Human1.46654964
50CBP_21632823_ChIP-Seq_H3396_Human1.45460696
51RXR_22108803_ChIP-Seq_LS180_Human1.44651494
52CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.44448811
53ZNF217_24962896_ChIP-Seq_MCF-7_Human1.44346889
54P300_19829295_ChIP-Seq_ESCs_Human1.42900775
55ELF5_23300383_ChIP-Seq_T47D_Human1.42594805
56CBP_20019798_ChIP-Seq_JUKART_Human1.41636014
57IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.41636014
58PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.39470761
59FOXM1_23109430_ChIP-Seq_U2OS_Human1.38953191
60MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.38479856
61TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.37329732
62RXR_22158963_ChIP-Seq_LIVER_Mouse1.37122607
63GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.35142225
64MYC_18555785_ChIP-Seq_MESCs_Mouse1.34836921
65NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.34544537
66NRF2_20460467_ChIP-Seq_MEFs_Mouse1.34544537
67SMAD4_21799915_ChIP-Seq_A2780_Human1.34409422
68RNF2_27304074_Chip-Seq_ESCs_Mouse1.34061820
69CTBP2_25329375_ChIP-Seq_LNCAP_Human1.34033430
70HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.32497499
71EED_16625203_ChIP-ChIP_MESCs_Mouse1.32336753
72PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.32080605
73KLF5_20875108_ChIP-Seq_MESCs_Mouse1.31928127
74FUS_26573619_Chip-Seq_HEK293_Human1.30839820
75PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.30017830
76POU3F2_20337985_ChIP-ChIP_501MEL_Human1.27738689
77CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.26457503
78CTBP1_25329375_ChIP-Seq_LNCAP_Human1.25815733
79EP300_21415370_ChIP-Seq_HL-1_Mouse1.25739958
80WT1_19549856_ChIP-ChIP_CCG9911_Human1.25561297
81SMAD3_21741376_ChIP-Seq_EPCs_Human1.25337478
82SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.24508749
83PHF8_20622853_ChIP-Seq_HELA_Human1.24474536
84NANOG_20526341_ChIP-Seq_ESCs_Human1.23965616
85TP53_18474530_ChIP-ChIP_U2OS_Human1.23170190
86HTT_18923047_ChIP-ChIP_STHdh_Human1.22943248
87CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.21366875
88TOP2B_26459242_ChIP-Seq_MCF-7_Human1.20068737
89IGF1R_20145208_ChIP-Seq_DFB_Human1.19753068
90MYC_19030024_ChIP-ChIP_MESCs_Mouse1.19676804
91HNFA_21074721_ChIP-Seq_CACO-2_Human1.18977017
92PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.17944708
93TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17838013
94ZFP57_27257070_Chip-Seq_ESCs_Mouse1.16361296
95SMAD_19615063_ChIP-ChIP_OVARY_Human1.16150960
96AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.15978019
97TAF15_26573619_Chip-Seq_HEK293_Human1.15563492
98RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.15410064
99HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.14553471
100GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.14017087
101AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.13447397
102LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13139636
103NR3C1_23031785_ChIP-Seq_PC12_Mouse1.10849414
104BCAT_22108803_ChIP-Seq_LS180_Human1.10437686
105WT1_25993318_ChIP-Seq_PODOCYTE_Human1.10132163
106STAT3_23295773_ChIP-Seq_U87_Human1.09952930
107FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.09165944
108TBL1_22424771_ChIP-Seq_293T_Human1.09043469
109CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.07740122
110AR_25329375_ChIP-Seq_VCAP_Human1.07027832
111GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.06934950
112MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.06050211
113SMAD4_21741376_ChIP-Seq_EPCs_Human1.04444956
114TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.04342235
115ARNT_22903824_ChIP-Seq_MCF-7_Human1.03849584
116CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.03317376
117THAP11_20581084_ChIP-Seq_MESCs_Mouse1.03270180
118* FOXA2_19822575_ChIP-Seq_HepG2_Human1.02909237
119E2F1_18555785_ChIP-Seq_MESCs_Mouse1.02454958
120SOX2_21211035_ChIP-Seq_LN229_Gbm1.02216450
121MYC_18358816_ChIP-ChIP_MESCs_Mouse1.01793059
122PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.01706158
123EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.01151554
124AUTS2_25519132_ChIP-Seq_293T-REX_Human1.01033516
125SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.00904019
126ESR2_21235772_ChIP-Seq_MCF-7_Human1.00071969
127EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.99467649
128PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.98518056
129ERG_21242973_ChIP-ChIP_JURKAT_Human0.98022049
130NFYB_21822215_ChIP-Seq_K562_Human0.97234603
131FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.97155013
132PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.96796561
133RNF2_27304074_Chip-Seq_NSC_Mouse0.96362386
134CREB1_15753290_ChIP-ChIP_HEK293T_Human0.96347697
135TBX5_21415370_ChIP-Seq_HL-1_Mouse0.95862655
136POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.95826512
137TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95826512
138NFYA_21822215_ChIP-Seq_K562_Human0.95786518
139TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.95166321
140GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94912409
141CBX2_27304074_Chip-Seq_ESCs_Mouse0.94559353
142NCOR_22424771_ChIP-Seq_293T_Human0.94190710
143FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.93783743
144FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.93548519
145GATA6_21074721_ChIP-Seq_CACO-2_Human0.92638555
146LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.92325259
147RARB_27405468_Chip-Seq_BRAIN_Mouse0.92318637
148AR_21909140_ChIP-Seq_LNCAP_Human0.91950117
149PRDM14_20953172_ChIP-Seq_ESCs_Human0.91920247
150REST_21632747_ChIP-Seq_MESCs_Mouse0.91886507
151HOXB7_26014856_ChIP-Seq_BT474_Human0.91259462
152RBPJ_21746931_ChIP-Seq_IB4_Human0.91205229
153GABP_19822575_ChIP-Seq_HepG2_Human0.90023989
154ZNF274_21170338_ChIP-Seq_K562_Hela0.89888419
155BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.89252008
156MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.88812442
157LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.88520586
158IKZF1_21737484_ChIP-ChIP_HCT116_Human0.87646421
159CHD1_26751641_Chip-Seq_LNCaP_Human0.87605640
160ETV1_20927104_ChIP-Seq_GIST48_Human0.87325051
161SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.87231914
162SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.87060221
163SMAD4_21741376_ChIP-Seq_HESCs_Human0.86972742
164RING1B_27294783_Chip-Seq_ESCs_Mouse0.86504225
165VDR_22108803_ChIP-Seq_LS180_Human0.86370191
166FOXM1_26456572_ChIP-Seq_MCF-7_Human0.86117741
167RBPJ_22232070_ChIP-Seq_NCS_Mouse0.85867593
168NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.85667100
169NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.84618469
170RUNX2_22187159_ChIP-Seq_PCA_Human0.84608587
171TCF4_22108803_ChIP-Seq_LS180_Human0.84440276
172TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.84418347
173HOXB4_20404135_ChIP-ChIP_EML_Mouse0.82933889
174SOX2_19829295_ChIP-Seq_ESCs_Human0.82115595
175NANOG_19829295_ChIP-Seq_ESCs_Human0.82115595
176MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.81761086
177IRF1_19129219_ChIP-ChIP_H3396_Human0.81508103
178FOXP3_21729870_ChIP-Seq_TREG_Human0.81288133
179ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.80998191
180PADI4_21655091_ChIP-ChIP_MCF-7_Human0.80673572
181CDX2_22108803_ChIP-Seq_LS180_Human0.80530743
182ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.80222277
183E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.79503005
184PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.78832667

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color3.68778649
2MP0005623_abnormal_meninges_morphology2.87615873
3MP0006036_abnormal_mitochondrial_physio2.73171929
4MP0004270_analgesia2.64172338
5MP0004885_abnormal_endolymph2.49980031
6MP0009780_abnormal_chondrocyte_physiolo2.44377677
7MP0002254_reproductive_system_inflammat2.40193660
8MP0005360_urolithiasis2.38926007
9MP0005451_abnormal_body_composition2.32363065
10MP0005330_cardiomyopathy2.31767956
11MP0001188_hyperpigmentation2.29821478
12MP0004859_abnormal_synaptic_plasticity2.28126109
13MP0004084_abnormal_cardiac_muscle2.27615434
14MP0000013_abnormal_adipose_tissue2.18586306
15MP0002269_muscular_atrophy2.13898467
16MP0003690_abnormal_glial_cell2.13317118
17MP0000920_abnormal_myelination2.11803708
18MP0003880_abnormal_central_pattern2.07829341
19MP0003195_calcinosis2.03916005
20MP0001986_abnormal_taste_sensitivity2.02980217
21MP0003941_abnormal_skin_development2.01066722
22MP0003890_abnormal_embryonic-extraembry2.00886061
23MP0005423_abnormal_somatic_nervous2.00168478
24MP0002009_preneoplasia2.00036511
25MP0004147_increased_porphyrin_level1.99781271
26MP0004145_abnormal_muscle_electrophysio1.98606976
27MP0004043_abnormal_pH_regulation1.98451514
28MP0002139_abnormal_hepatobiliary_system1.97536777
29MP0004233_abnormal_muscle_weight1.94147548
30MP0005332_abnormal_amino_acid1.87755691
31MP0010234_abnormal_vibrissa_follicle1.87529180
32MP0005646_abnormal_pituitary_gland1.87371879
33MP0002160_abnormal_reproductive_system1.87177671
34MP0009840_abnormal_foam_cell1.87175489
35MP0003646_muscle_fatigue1.83228372
36MP0008004_abnormal_stomach_pH1.83156717
37MP0003315_abnormal_perineum_morphology1.76582065
38MP0000747_muscle_weakness1.74029368
39MP0001765_abnormal_ion_homeostasis1.70187249
40MP0002272_abnormal_nervous_system1.68380974
41MP0001984_abnormal_olfaction1.66596412
42MP0003635_abnormal_synaptic_transmissio1.64358432
43MP0009046_muscle_twitch1.63376088
44MP0009379_abnormal_foot_pigmentation1.60559437
45MP0008875_abnormal_xenobiotic_pharmacok1.58019863
46MP0002064_seizures1.54129399
47MP0004087_abnormal_muscle_fiber1.54094050
48MP0009384_cardiac_valve_regurgitation1.53081031
49MP0001486_abnormal_startle_reflex1.52009295
50MP0002734_abnormal_mechanical_nocicepti1.51755424
51MP0003634_abnormal_glial_cell1.51442253
52MP0001764_abnormal_homeostasis1.49831649
53MP0003123_paternal_imprinting1.49129070
54MP0003633_abnormal_nervous_system1.45031108
55MP0001485_abnormal_pinna_reflex1.44958170
56MP0001968_abnormal_touch/_nociception1.44328477
57MP0009745_abnormal_behavioral_response1.43423450
58MP0005085_abnormal_gallbladder_physiolo1.41592866
59MP0003252_abnormal_bile_duct1.41067235
60MP0003950_abnormal_plasma_membrane1.40495627
61MP0001440_abnormal_grooming_behavior1.37437816
62MP0002127_abnormal_cardiovascular_syste1.37164480
63MP0005365_abnormal_bile_salt1.36880967
64MP0005620_abnormal_muscle_contractility1.34520931
65MP0001666_abnormal_nutrient_absorption1.34146288
66MP0004133_heterotaxia1.34125964
67MP0004215_abnormal_myocardial_fiber1.33813053
68MP0000749_muscle_degeneration1.32689594
69MP0002736_abnormal_nociception_after1.31706354
70MP0000759_abnormal_skeletal_muscle1.30908781
71MP0005058_abnormal_lysosome_morphology1.30394017
72MP0005636_abnormal_mineral_homeostasis1.29438478
73MP0001661_extended_life_span1.27744553
74MP0006072_abnormal_retinal_apoptosis1.27717648
75MP0002090_abnormal_vision1.27050727
76MP0002572_abnormal_emotion/affect_behav1.26276627
77MP0002735_abnormal_chemical_nociception1.26138742
78MP0005266_abnormal_metabolism1.25159102
79MP0010329_abnormal_lipoprotein_level1.19587244
80MP0001905_abnormal_dopamine_level1.17385584
81MP0003191_abnormal_cellular_cholesterol1.17111642
82MP0005410_abnormal_fertilization1.16789646
83MP0001873_stomach_inflammation1.16568018
84MP0004019_abnormal_vitamin_homeostasis1.16076972
85MP0001501_abnormal_sleep_pattern1.15646256
86MP0002909_abnormal_adrenal_gland1.15606786
87MP0001299_abnormal_eye_distance/1.15084716
88MP0008569_lethality_at_weaning1.13115860
89MP0003329_amyloid_beta_deposits1.12811245
90MP0003718_maternal_effect1.12521396
91MP0001958_emphysema1.11988005
92MP0003656_abnormal_erythrocyte_physiolo1.11131278
93MP0002067_abnormal_sensory_capabilities1.10078212
94MP0005647_abnormal_sex_gland1.09519851
95MP0002063_abnormal_learning/memory/cond1.08065547
96MP0002229_neurodegeneration1.06940288
97MP0005670_abnormal_white_adipose1.05963846
98MP0005584_abnormal_enzyme/coenzyme_acti1.05566666
99MP0005389_reproductive_system_phenotype1.05143411
100MP0009697_abnormal_copulation1.04452063
101MP0004142_abnormal_muscle_tone1.02258334
102MP0002557_abnormal_social/conspecific_i1.00185707
103MP0003868_abnormal_feces_composition0.98697776
104MP0006035_abnormal_mitochondrial_morpho0.97105022
105MP0003631_nervous_system_phenotype0.95583026
106MP0000778_abnormal_nervous_system0.95410483
107MP0009250_abnormal_appendicular_skeleto0.94793228
108MP0005409_darkened_coat_color0.94533458
109MP0002118_abnormal_lipid_homeostasis0.93175793
110MP0000537_abnormal_urethra_morphology0.92782036
111MP0000751_myopathy0.90741097
112MP0002928_abnormal_bile_duct0.90668921
113MP0000230_abnormal_systemic_arterial0.89802317
114MP0004858_abnormal_nervous_system0.88168270
115MP0002837_dystrophic_cardiac_calcinosis0.88052507
116MP0005551_abnormal_eye_electrophysiolog0.87797680
117MP0003806_abnormal_nucleotide_metabolis0.86313341
118MP0001664_abnormal_digestion0.85816617
119MP0001756_abnormal_urination0.85790937
120MP0000955_abnormal_spinal_cord0.85530181
121MP0002108_abnormal_muscle_morphology0.84843250
122MP0001529_abnormal_vocalization0.84715896
123MP0002882_abnormal_neuron_morphology0.83374124
124MP0002938_white_spotting0.83286054
125MP0002078_abnormal_glucose_homeostasis0.83166801
126MP0004742_abnormal_vestibular_system0.83139264
127MP0001502_abnormal_circadian_rhythm0.83124662
128MP0000003_abnormal_adipose_tissue0.82309704
129MP0009643_abnormal_urine_homeostasis0.82279184
130MP0002972_abnormal_cardiac_muscle0.81927854
131MP0002822_catalepsy0.79533139
132MP0005310_abnormal_salivary_gland0.79523937
133MP0001663_abnormal_digestive_system0.79452811
134MP0005381_digestive/alimentary_phenotyp0.78958442
135MP0002066_abnormal_motor_capabilities/c0.78705013
136MP0004036_abnormal_muscle_relaxation0.78669113
137MP0001544_abnormal_cardiovascular_syste0.78536852
138MP0005385_cardiovascular_system_phenoty0.78536852
139MP0005369_muscle_phenotype0.78501601
140MP0005319_abnormal_enzyme/_coenzyme0.78092937
141MP0001919_abnormal_reproductive_system0.77774514
142MP0005187_abnormal_penis_morphology0.77757835
143MP0004134_abnormal_chest_morphology0.77471182
144MP0003186_abnormal_redox_activity0.77163874
145MP0002876_abnormal_thyroid_physiology0.75236841
146MP0010368_abnormal_lymphatic_system0.75123408
147MP0002102_abnormal_ear_morphology0.74973681
148MP0008775_abnormal_heart_ventricle0.73928437
149MP0004130_abnormal_muscle_cell0.72526360
150MP0001881_abnormal_mammary_gland0.72216827
151MP0002133_abnormal_respiratory_system0.72185041
152MP0010630_abnormal_cardiac_muscle0.72162613
153MP0005253_abnormal_eye_physiology0.71855722
154MP0009672_abnormal_birth_weight0.71366210
155MP0004272_abnormal_basement_membrane0.70470156
156MP0002138_abnormal_hepatobiliary_system0.68644346
157MP0008007_abnormal_cellular_replicative0.67575941
158MP0005376_homeostasis/metabolism_phenot0.65895942
159MP0003283_abnormal_digestive_organ0.60321211
160MP0002796_impaired_skin_barrier0.57660695
161MP0003936_abnormal_reproductive_system0.57214341
162MP0002106_abnormal_muscle_physiology0.56554890
163MP0001944_abnormal_pancreas_morphology0.53843089
164MP0003011_delayed_dark_adaptation0.53306615
165MP0005334_abnormal_fat_pad0.53134400
166MP0008058_abnormal_DNA_repair0.51247224
167MP0000762_abnormal_tongue_morphology0.49637486
168MP0000609_abnormal_liver_physiology0.48208644
169MP0000462_abnormal_digestive_system0.48174701

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)8.24499616
2Abnormal ciliary motility (HP:0012262)8.01874448
3Abnormal respiratory motile cilium physiology (HP:0012261)7.98288438
4Rhinitis (HP:0012384)6.08477177
5Reduced antithrombin III activity (HP:0001976)5.61599623
6Abnormal respiratory epithelium morphology (HP:0012253)5.41415328
7Abnormal respiratory motile cilium morphology (HP:0005938)5.41415328
8Muscle fiber inclusion bodies (HP:0100299)5.19176213
9Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)5.18246016
10Exercise-induced muscle cramps (HP:0003710)4.99572325
11Dynein arm defect of respiratory motile cilia (HP:0012255)4.67091504
12Absent/shortened dynein arms (HP:0200106)4.67091504
13Muscle hypertrophy of the lower extremities (HP:0008968)4.39640714
14Calf muscle hypertrophy (HP:0008981)4.33982608
15Hyporeflexia of lower limbs (HP:0002600)4.33180729
16Nemaline bodies (HP:0003798)4.18716286
17Prolonged partial thromboplastin time (HP:0003645)4.16749617
18Chronic bronchitis (HP:0004469)3.88336897
19Hyperinsulinemic hypoglycemia (HP:0000825)3.87069547
20EMG: myopathic abnormalities (HP:0003458)3.85478358
21Abnormality of the calf musculature (HP:0001430)3.80400414
22Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.59166869
23Degeneration of the lateral corticospinal tracts (HP:0002314)3.59166869
24Rimmed vacuoles (HP:0003805)3.52569065
25Deep venous thrombosis (HP:0002625)3.51749771
26Centrally nucleated skeletal muscle fibers (HP:0003687)3.39970177
27Abnormality of monocarboxylic acid metabolism (HP:0010996)3.37783492
28Abnormality of the intrinsic pathway (HP:0010989)3.26065709
29Hypoglycemic seizures (HP:0002173)3.23723596
30Rhabdomyolysis (HP:0003201)3.23022405
31Bronchiectasis (HP:0002110)3.17943173
32Neck muscle weakness (HP:0000467)3.17245189
33Proximal amyotrophy (HP:0007126)3.10480840
34Abnormality of the shoulder girdle musculature (HP:0001435)3.09979298
35Bile duct proliferation (HP:0001408)3.09402346
36Abnormal biliary tract physiology (HP:0012439)3.09402346
37Back pain (HP:0003418)2.95363418
38Clumsiness (HP:0002312)2.91495040
39Abnormal drinking behavior (HP:0030082)2.90304182
40Polydipsia (HP:0001959)2.90304182
41Retinal dysplasia (HP:0007973)2.89749161
42Myoglobinuria (HP:0002913)2.89465323
43Scapular winging (HP:0003691)2.77370297
44Increased circulating renin level (HP:0000848)2.77141998
45Pancreatic cysts (HP:0001737)2.77033733
46Muscle fiber splitting (HP:0003555)2.74866902
47Pancreatic fibrosis (HP:0100732)2.74863180
48Bulbar palsy (HP:0001283)2.71057460
49Abnormality of the corticospinal tract (HP:0002492)2.71030576
50Right ventricular cardiomyopathy (HP:0011663)2.68118247
51Resting tremor (HP:0002322)2.66189554
52Abnormality of serine family amino acid metabolism (HP:0010894)2.59136187
53Abnormality of glycine metabolism (HP:0010895)2.59136187
54Ketoacidosis (HP:0001993)2.56831410
55Limb-girdle muscle atrophy (HP:0003797)2.56655268
56Abnormal pancreas size (HP:0012094)2.55784547
57Distal arthrogryposis (HP:0005684)2.54403809
58Symptomatic seizures (HP:0011145)2.53853820
59Metabolic alkalosis (HP:0200114)2.52836656
60Male infertility (HP:0003251)2.52540757
61Abnormal urine output (HP:0012590)2.49926278
62Scanning speech (HP:0002168)2.49003889
63Increased muscle lipid content (HP:0009058)2.48811913
64Myopathic facies (HP:0002058)2.47311589
65Abnormality of pyrimidine metabolism (HP:0004353)2.47054826
66Neoplasm of the adrenal gland (HP:0100631)2.45012631
67Hepatoblastoma (HP:0002884)2.42222579
68Abnormality of endocrine pancreas physiology (HP:0012093)2.41679267
69Abnormality of the pancreatic islet cells (HP:0006476)2.41679267
70Cystic liver disease (HP:0006706)2.41678032
71Polyuria (HP:0000103)2.40755701
72Muscular dystrophy (HP:0003560)2.40362112
73True hermaphroditism (HP:0010459)2.40298318
74Decreased activity of mitochondrial respiratory chain (HP:0008972)2.38811460
75Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.38811460
76Malignant hyperthermia (HP:0002047)2.37860290
77Spinal rigidity (HP:0003306)2.34821708
78Abnormality of methionine metabolism (HP:0010901)2.34810635
79Hypoglycemic coma (HP:0001325)2.34290165
80Acute encephalopathy (HP:0006846)2.32414734
81Hypobetalipoproteinemia (HP:0003563)2.31554922
82Hyperglycinuria (HP:0003108)2.29488541
83Hyperventilation (HP:0002883)2.28990025
84Acute necrotizing encephalopathy (HP:0006965)2.28806344
85Retinal atrophy (HP:0001105)2.27634628
86Type I transferrin isoform profile (HP:0003642)2.26763534
87Weak cry (HP:0001612)2.25265326
88Cerebral hypomyelination (HP:0006808)2.22933425
89Abnormal mitochondria in muscle tissue (HP:0008316)2.22696123
90Medial flaring of the eyebrow (HP:0010747)2.18718332
91Abnormal glycosylation (HP:0012345)2.18705792
92Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.18705792
93Abnormal protein N-linked glycosylation (HP:0012347)2.18705792
94Abnormal protein glycosylation (HP:0012346)2.18705792
95Frequent falls (HP:0002359)2.17098058
96Ketosis (HP:0001946)2.16398844
97Abnormality of serum amino acid levels (HP:0003112)2.16225643
98Respiratory insufficiency due to muscle weakness (HP:0002747)2.15722974
99Hypomagnesemia (HP:0002917)2.15119513
100Abnormality of renal excretion (HP:0011036)2.13324792
101Cerebral edema (HP:0002181)2.12128600
102Gait imbalance (HP:0002141)2.11932195
103Increased intramyocellular lipid droplets (HP:0012240)2.10859265
104Difficulty climbing stairs (HP:0003551)2.10665990
105Intention tremor (HP:0002080)2.10658823
106Increased serum pyruvate (HP:0003542)2.09780108
107Termporal pattern (HP:0011008)2.09723630
108Insidious onset (HP:0003587)2.09723630
109Pheochromocytoma (HP:0002666)2.09490216
110Generalized aminoaciduria (HP:0002909)2.09471257
111Oligomenorrhea (HP:0000876)2.09396619
112Renal Fanconi syndrome (HP:0001994)2.08592134
113Increased CSF lactate (HP:0002490)2.08429981
114Congenital primary aphakia (HP:0007707)2.07619381
115Abnormality of skeletal muscle fiber size (HP:0012084)2.06023467
116Type 1 muscle fiber predominance (HP:0003803)2.03319320
117Hyperglycemia (HP:0003074)2.03184327
118Enlarged kidneys (HP:0000105)2.01138572
119Methylmalonic acidemia (HP:0002912)2.00983774
120Nasal polyposis (HP:0100582)2.00868578
121Muscle stiffness (HP:0003552)2.00784131
122Focal motor seizures (HP:0011153)2.00754225
123Neurofibrillary tangles (HP:0002185)2.00427296
124Sudden death (HP:0001699)1.98662776
125Mitochondrial inheritance (HP:0001427)1.97582719
126Lethargy (HP:0001254)1.97548734
127Recurrent sinusitis (HP:0011108)1.96566650
128Genetic anticipation (HP:0003743)1.95129265
129Inability to walk (HP:0002540)1.94343620
130Progressive macrocephaly (HP:0004481)1.93796614
131Pancreatic islet-cell hyperplasia (HP:0004510)1.93580322
132Tubulointerstitial nephritis (HP:0001970)1.92570124
133Dilated cardiomyopathy (HP:0001644)1.92080028
134Abnormality of renal resorption (HP:0011038)1.91324154
135Hypokalemic alkalosis (HP:0001949)1.90523741
136Exercise-induced myalgia (HP:0003738)1.90106931
137Abnormality of magnesium homeostasis (HP:0004921)1.88684657
138Abnormality of aspartate family amino acid metabolism (HP:0010899)1.88321334
139Neoplasm of head and neck (HP:0012288)1.88278895
140Esophageal neoplasm (HP:0100751)1.88278895
141Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.88226839
142Neuroendocrine neoplasm (HP:0100634)1.87165179
143Methylmalonic aciduria (HP:0012120)1.86062691
144Hypolipoproteinemia (HP:0010981)1.84576403
145Hyperphosphaturia (HP:0003109)1.84503030
146Occipital encephalocele (HP:0002085)1.83499722
147Abnormality of the dental pulp (HP:0006479)1.83254735
148Hyperactive renin-angiotensin system (HP:0000841)1.80154623
149Urinary urgency (HP:0000012)1.80052954
150Nephrogenic diabetes insipidus (HP:0009806)1.79725630
151Infantile muscular hypotonia (HP:0008947)1.79091270
152Agitation (HP:0000713)1.78765957
153Atonic seizures (HP:0010819)1.78506480
154Abnormality of aromatic amino acid family metabolism (HP:0004338)1.76815051
155Hypokalemia (HP:0002900)1.76810164
156Dicarboxylic aciduria (HP:0003215)1.76300536
157Lipid accumulation in hepatocytes (HP:0006561)1.74643512
158Asplenia (HP:0001746)1.73932439
159Megalencephaly (HP:0001355)1.72922237
160Genital tract atresia (HP:0001827)1.72841896
161Infertility (HP:0000789)1.72448506
162Intrahepatic cholestasis (HP:0001406)1.71730844
163Hypoplasia of the iris (HP:0007676)1.70891153
164Spastic gait (HP:0002064)1.70283352
165Hyperaldosteronism (HP:0000859)1.70188027
166Spontaneous abortion (HP:0005268)1.69260344
167Abnormality of potassium homeostasis (HP:0011042)1.68239761
168Glycosuria (HP:0003076)1.67914097
169Abnormality of urine glucose concentration (HP:0011016)1.67914097
170Abnormality of the dental root (HP:0006486)1.67631257
171Taurodontia (HP:0000679)1.67631257
172Abnormality of permanent molar morphology (HP:0011071)1.67631257
173Postaxial foot polydactyly (HP:0001830)1.64331464
174Hyperglycinemia (HP:0002154)1.63778747
175Molar tooth sign on MRI (HP:0002419)1.63714582
176Abnormality of midbrain morphology (HP:0002418)1.63714582
177Increased hepatocellular lipid droplets (HP:0006565)1.62908097
178Psychosis (HP:0000709)1.62110351
179Abnormality of renin-angiotensin system (HP:0000847)1.61739131
180Abnormality of the middle phalanges of the toes (HP:0010183)1.60758428
181Hydroxyprolinuria (HP:0003080)1.59497154
182Abnormality of proline metabolism (HP:0010907)1.59497154
183Abnormality of molar (HP:0011077)1.58996868
184Abnormality of molar morphology (HP:0011070)1.58996868
185Cerebral inclusion bodies (HP:0100314)1.58523212
186Single umbilical artery (HP:0001195)1.58381524

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK156.14722095
2STK394.22789321
3EIF2AK13.34400582
4OXSR13.15428917
5MARK32.98922216
6LATS12.87273455
7TNIK2.86009459
8WNK42.72519554
9BUB12.27662583
10PNCK2.27541778
11MAP3K92.25126883
12PBK2.20312189
13MUSK2.14855473
14SIK12.09684940
15PKN22.08898148
16EPHA42.02979420
17MST41.99892668
18CDK191.90342949
19EIF2AK31.83216887
20SGK2231.70622682
21SGK4941.70622682
22WEE11.69282741
23ARAF1.63781242
24PIK3CG1.61646029
25ZAK1.59031529
26INSRR1.55502223
27WNK31.51244006
28BRAF1.40199857
29EPHB11.39152958
30WNK11.37810776
31PKN11.31565288
32IRAK21.24144769
33TNK21.23399767
34IRAK11.22778638
35AKT31.21229966
36NTRK31.18087835
37NME11.17957270
38PAK31.15979145
39MAP2K71.14971376
40NTRK11.10923046
41MAP3K11.10148858
42FLT31.04242086
43NEK21.02100888
44PHKG21.01835156
45PHKG11.01835156
46TSSK60.97044446
47PINK10.96820129
48DYRK30.96786556
49STK38L0.94935666
50BMPR1B0.94808738
51CAMK2B0.94314960
52PLK30.94104564
53PLK10.94049335
54FRK0.93379475
55MAP3K20.91981629
56MAP3K70.91871331
57CAMK2G0.91510680
58MAP3K50.90946144
59MELK0.90073977
60LATS20.90062483
61CAMK2A0.89088468
62MAP3K40.88611681
63CASK0.87469041
64NEK60.87468589
65CAMK1G0.87203192
66TAF10.85582663
67ABL20.84754615
68MOS0.83829276
69MAPKAPK50.83371491
70CDK30.82819658
71CAMK2D0.82794411
72ROCK20.82145414
73STK160.80912535
74LRRK20.79622774
75MAPKAPK30.79503451
76DMPK0.79072619
77NUAK10.77284250
78PRKCG0.75913040
79BCKDK0.75782811
80GRK10.75620587
81PTK2B0.74985973
82TRIM280.74609048
83CDK50.70397623
84CAMK10.70329892
85CSNK1G20.69240325
86TRPM70.69189547
87OBSCN0.68691922
88SGK20.68105948
89MAPK120.67897316
90FGFR20.67519789
91NME20.67386270
92MAP2K40.66359428
93AKT20.65862087
94MARK20.65554266
95TTK0.65436089
96CSNK1A1L0.63703039
97MAP3K120.62808196
98PRKCQ0.62367512
99PIK3CA0.62208975
100HIPK20.62162000
101CSK0.61513949
102PRKAA20.60818456
103UHMK10.60743259
104BCR0.60406364
105NTRK20.59059652
106AURKB0.58820218
107SRPK10.58454242
108MYLK0.56967158
109PRKCH0.54478307
110STK30.54429408
111CSNK1G30.54183822
112SGK30.54014784
113CDC42BPA0.53235436
114FGFR10.52779428
115FES0.52199161
116STK40.52178946
117LMTK20.51649633
118PDK10.51366720
119TLK10.51102643
120DYRK20.49041535
121MINK10.48891778
122DAPK20.46623576
123PAK10.46175163
124MAP3K130.46109383
125PRKG10.45744056
126PRKG20.45382152
127FYN0.45355262
128NLK0.45005185
129TIE10.44216922
130CSNK1E0.44039019
131PRKCE0.43144299
132PRKD20.42801911
133PRKD10.42437988
134RPS6KB10.41714130
135CSNK1G10.41098265
136RET0.39283815
137VRK10.39127957
138PDPK10.37582492
139TAOK10.37369449
140PRKACA0.37043561
141ATM0.36725150
142INSR0.36140078
143ITK0.36059862
144GSK3A0.35812118
145FER0.35767540
146JAK20.35537440
147KSR20.35136414
148PRKACB0.32751465
149CSNK2A20.30673126
150MAP3K30.30358429
151CSNK1A10.28921236
152ROCK10.28895795
153RPS6KA50.28851237
154TTN0.27916026
155CDK140.25817078
156CSNK2A10.24676347
157NEK10.21375144
158MAP4K20.19931349
159AURKA0.19319494

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000724.15981556
2Nitrogen metabolism_Homo sapiens_hsa009103.05247760
3Butanoate metabolism_Homo sapiens_hsa006502.96118275
4Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.89666057
5Sulfur metabolism_Homo sapiens_hsa009202.40200522
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.32141581
7Propanoate metabolism_Homo sapiens_hsa006402.29927511
82-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.17817887
9Fatty acid biosynthesis_Homo sapiens_hsa000612.12566910
10Fatty acid elongation_Homo sapiens_hsa000622.10854963
11Phenylalanine metabolism_Homo sapiens_hsa003602.07524263
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.99062117
13Retinol metabolism_Homo sapiens_hsa008301.94007657
14Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.91064225
15Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.85377399
16Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.84142196
17Proteasome_Homo sapiens_hsa030501.68728197
18Primary bile acid biosynthesis_Homo sapiens_hsa001201.63783803
19Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.59828801
20Fatty acid degradation_Homo sapiens_hsa000711.57290347
21Complement and coagulation cascades_Homo sapiens_hsa046101.54688858
22Cysteine and methionine metabolism_Homo sapiens_hsa002701.52206959
23Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.50629267
24Steroid biosynthesis_Homo sapiens_hsa001001.50596940
25Fatty acid metabolism_Homo sapiens_hsa012121.49615858
26Drug metabolism - other enzymes_Homo sapiens_hsa009831.48150004
27Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.47380577
28Pyruvate metabolism_Homo sapiens_hsa006201.46037077
29Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.42783737
30Peroxisome_Homo sapiens_hsa041461.42274384
31Parkinsons disease_Homo sapiens_hsa050121.39933121
32Olfactory transduction_Homo sapiens_hsa047401.35465661
33Tyrosine metabolism_Homo sapiens_hsa003501.32544998
34GABAergic synapse_Homo sapiens_hsa047271.31344946
35Vitamin B6 metabolism_Homo sapiens_hsa007501.29700181
36PPAR signaling pathway_Homo sapiens_hsa033201.29279781
37Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.25237505
38Insulin secretion_Homo sapiens_hsa049111.24405020
39Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.23610954
40Circadian entrainment_Homo sapiens_hsa047131.22209806
41Gastric acid secretion_Homo sapiens_hsa049711.20588196
42Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.19003012
43Selenocompound metabolism_Homo sapiens_hsa004501.18998833
44Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.16479824
45Salivary secretion_Homo sapiens_hsa049701.15044194
46Glutathione metabolism_Homo sapiens_hsa004801.13845948
47Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.11448758
48Bile secretion_Homo sapiens_hsa049761.09278005
49Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.04902720
50Biosynthesis of amino acids_Homo sapiens_hsa012301.04774155
51Glutamatergic synapse_Homo sapiens_hsa047241.03967474
52Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.02370062
53Folate biosynthesis_Homo sapiens_hsa007901.00835760
54Sphingolipid metabolism_Homo sapiens_hsa006001.00138828
55Pentose and glucuronate interconversions_Homo sapiens_hsa000400.99548630
56Protein export_Homo sapiens_hsa030600.99003662
57Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.98929430
58Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.97106835
59Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.96499006
60Pentose phosphate pathway_Homo sapiens_hsa000300.91998060
61Tryptophan metabolism_Homo sapiens_hsa003800.91700354
62One carbon pool by folate_Homo sapiens_hsa006700.90898791
63Morphine addiction_Homo sapiens_hsa050320.88376428
64beta-Alanine metabolism_Homo sapiens_hsa004100.87497688
65Maturity onset diabetes of the young_Homo sapiens_hsa049500.86852479
66RNA polymerase_Homo sapiens_hsa030200.85728028
67Arginine biosynthesis_Homo sapiens_hsa002200.85017961
68Renin secretion_Homo sapiens_hsa049240.84881841
69Ovarian steroidogenesis_Homo sapiens_hsa049130.82128243
70Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.81578030
71Long-term depression_Homo sapiens_hsa047300.79122847
72Histidine metabolism_Homo sapiens_hsa003400.78827673
73Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.77729290
74Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.77632698
75Aldosterone synthesis and secretion_Homo sapiens_hsa049250.77565076
76Steroid hormone biosynthesis_Homo sapiens_hsa001400.77424410
77Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.77130776
78Dopaminergic synapse_Homo sapiens_hsa047280.75608083
79Synaptic vesicle cycle_Homo sapiens_hsa047210.75362202
80Serotonergic synapse_Homo sapiens_hsa047260.74408458
81Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.74100863
82Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.73381211
83Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.73368722
84Linoleic acid metabolism_Homo sapiens_hsa005910.73225112
85Fructose and mannose metabolism_Homo sapiens_hsa000510.72096175
86Calcium signaling pathway_Homo sapiens_hsa040200.71420350
87Glucagon signaling pathway_Homo sapiens_hsa049220.70953906
88Collecting duct acid secretion_Homo sapiens_hsa049660.70443192
89Cholinergic synapse_Homo sapiens_hsa047250.68646152
90Pancreatic secretion_Homo sapiens_hsa049720.67315468
91Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.66483223
92Ether lipid metabolism_Homo sapiens_hsa005650.66016114
93Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.65979864
94Oxidative phosphorylation_Homo sapiens_hsa001900.65566179
95Glycerolipid metabolism_Homo sapiens_hsa005610.65220663
96Starch and sucrose metabolism_Homo sapiens_hsa005000.65047155
97ABC transporters_Homo sapiens_hsa020100.64568130
98Thyroid hormone synthesis_Homo sapiens_hsa049180.63216708
99Alzheimers disease_Homo sapiens_hsa050100.63099930
100Taste transduction_Homo sapiens_hsa047420.62802855
101Vascular smooth muscle contraction_Homo sapiens_hsa042700.62201277
102Purine metabolism_Homo sapiens_hsa002300.61443662
103Amphetamine addiction_Homo sapiens_hsa050310.61427410
104Arginine and proline metabolism_Homo sapiens_hsa003300.60170108
105Long-term potentiation_Homo sapiens_hsa047200.59945331
106Circadian rhythm_Homo sapiens_hsa047100.59579287
107Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.59170824
108RNA degradation_Homo sapiens_hsa030180.58961772
109cAMP signaling pathway_Homo sapiens_hsa040240.58870242
110Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.58827816
111Regulation of autophagy_Homo sapiens_hsa041400.58053439
112Fanconi anemia pathway_Homo sapiens_hsa034600.57997896
113Mineral absorption_Homo sapiens_hsa049780.56487270
114Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.56360149
115Carbohydrate digestion and absorption_Homo sapiens_hsa049730.56051450
116Arachidonic acid metabolism_Homo sapiens_hsa005900.55631135
117Ribosome_Homo sapiens_hsa030100.55591919
118Cocaine addiction_Homo sapiens_hsa050300.55281518
119Pyrimidine metabolism_Homo sapiens_hsa002400.50358031
120Cardiac muscle contraction_Homo sapiens_hsa042600.50028165
121Vitamin digestion and absorption_Homo sapiens_hsa049770.49577702
122Huntingtons disease_Homo sapiens_hsa050160.48833162
123Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.48448470
124Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.48410048
125cGMP-PKG signaling pathway_Homo sapiens_hsa040220.47882942
126Carbon metabolism_Homo sapiens_hsa012000.47483840
127Oocyte meiosis_Homo sapiens_hsa041140.47034054
128SNARE interactions in vesicular transport_Homo sapiens_hsa041300.46993756
129Nicotine addiction_Homo sapiens_hsa050330.46094678
130Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.46078293
131Caffeine metabolism_Homo sapiens_hsa002320.45705483
132Chemical carcinogenesis_Homo sapiens_hsa052040.42016067
133Dilated cardiomyopathy_Homo sapiens_hsa054140.41755975
134Metabolic pathways_Homo sapiens_hsa011000.40661651
135Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.40582569
136Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.40533964
137Phosphatidylinositol signaling system_Homo sapiens_hsa040700.40224778
138Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.40037135
139Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.39445395
140Protein digestion and absorption_Homo sapiens_hsa049740.38672138
141Vibrio cholerae infection_Homo sapiens_hsa051100.37784315
142Oxytocin signaling pathway_Homo sapiens_hsa049210.36909280
143Lysine degradation_Homo sapiens_hsa003100.36681408
144Fat digestion and absorption_Homo sapiens_hsa049750.31686202
145AMPK signaling pathway_Homo sapiens_hsa041520.26781644
146Homologous recombination_Homo sapiens_hsa034400.25561588
147Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.21752361
148Sulfur relay system_Homo sapiens_hsa041220.19472063
149RNA transport_Homo sapiens_hsa030130.17264083

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