ACOT8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a peroxisomal thioesterase that appears to be involved more in the oxidation of fatty acids rather than in their formation. The encoded protein can bind to the human immunodeficiency virus-1 protein Nef, and mediate Nef-induced down-regulation of CD4 in T-cells. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1deoxyribonucleoside monophosphate metabolic process (GO:0009162)5.62054196
2protein maturation by protein folding (GO:0022417)5.23435674
3mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.75294793
4DNA deamination (GO:0045006)4.69748883
5respiratory electron transport chain (GO:0022904)4.66965765
6mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.60091091
7negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.55933805
8electron transport chain (GO:0022900)4.54477386
9GDP-mannose metabolic process (GO:0019673)4.48194285
10chaperone-mediated protein transport (GO:0072321)4.19375837
11ATP synthesis coupled proton transport (GO:0015986)4.15379177
12energy coupled proton transport, down electrochemical gradient (GO:0015985)4.15379177
13ribosomal small subunit assembly (GO:0000028)4.12159682
14proteasome assembly (GO:0043248)4.11320919
15viral transcription (GO:0019083)4.09790430
16L-phenylalanine metabolic process (GO:0006558)4.06319876
17erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.06319876
18L-phenylalanine catabolic process (GO:0006559)4.03031765
19erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.03031765
20pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.96974639
21translational termination (GO:0006415)3.93259872
22sequestering of actin monomers (GO:0042989)3.79267019
23aldehyde catabolic process (GO:0046185)3.72802807
24protein targeting to mitochondrion (GO:0006626)3.72385129
25protein neddylation (GO:0045116)3.71397398
26translational elongation (GO:0006414)3.70720779
27energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.65378647
28ATP hydrolysis coupled proton transport (GO:0015991)3.65378647
29oxaloacetate metabolic process (GO:0006107)3.65161923
30SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.62612522
31tricarboxylic acid cycle (GO:0006099)3.60852797
32nucleobase-containing small molecule interconversion (GO:0015949)3.60106396
33mitochondrial respiratory chain complex I assembly (GO:0032981)3.56879145
34NADH dehydrogenase complex assembly (GO:0010257)3.56879145
35mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.56879145
36cotranslational protein targeting to membrane (GO:0006613)3.54162572
37protein targeting to ER (GO:0045047)3.52668439
38mitotic nuclear envelope reassembly (GO:0007084)3.48791784
39nuclear envelope reassembly (GO:0031468)3.48791784
40establishment of protein localization to mitochondrion (GO:0072655)3.41533413
41pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.40846877
42protein localization to endoplasmic reticulum (GO:0070972)3.40398580
43establishment of protein localization to endoplasmic reticulum (GO:0072599)3.31331350
44GTP biosynthetic process (GO:0006183)3.29560994
45gluconeogenesis (GO:0006094)3.29529300
46aromatic amino acid family catabolic process (GO:0009074)3.26789162
47positive regulation of TOR signaling (GO:0032008)3.25012009
48pyrimidine nucleotide catabolic process (GO:0006244)3.24470287
49pteridine-containing compound biosynthetic process (GO:0042559)3.23314777
50monosaccharide biosynthetic process (GO:0046364)3.22338943
51protein localization to mitochondrion (GO:0070585)3.20308899
52protein insertion into membrane (GO:0051205)3.19419016
53pentose metabolic process (GO:0019321)3.19290073
54nucleobase biosynthetic process (GO:0046112)3.17367540
55translational initiation (GO:0006413)3.16170866
56deoxyribose phosphate biosynthetic process (GO:0046385)3.15980661
572-deoxyribonucleotide biosynthetic process (GO:0009265)3.15980661
58cellular protein complex disassembly (GO:0043624)3.15506556
59viral life cycle (GO:0019058)3.15151852
60regulation of cellular amine metabolic process (GO:0033238)3.14919017
61hexose biosynthetic process (GO:0019319)3.13582812
62folic acid metabolic process (GO:0046655)3.12514538
63ribosomal small subunit biogenesis (GO:0042274)3.12166114
64regulation of mitochondrial translation (GO:0070129)3.11985890
65regulation of oxidative phosphorylation (GO:0002082)3.11707812
66UTP biosynthetic process (GO:0006228)3.11191023
67purine nucleobase biosynthetic process (GO:0009113)3.09568193
68guanosine-containing compound biosynthetic process (GO:1901070)3.09224251
69oxidative phosphorylation (GO:0006119)3.08251949
70positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.06847996
71ATP biosynthetic process (GO:0006754)3.05296180
72ribosomal large subunit biogenesis (GO:0042273)3.04400807
73glycine metabolic process (GO:0006544)3.04293946
74purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.03940935
75purine nucleoside triphosphate biosynthetic process (GO:0009145)3.02368913
76heme biosynthetic process (GO:0006783)3.01978020
77hydrogen ion transmembrane transport (GO:1902600)2.99689555
78UTP metabolic process (GO:0046051)2.99480190
79translation (GO:0006412)2.99171119
80mitochondrial transport (GO:0006839)2.98934452
81regulation of cellular amino acid metabolic process (GO:0006521)2.97097612
82activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.96500100
83regulation of superoxide anion generation (GO:0032928)2.94664301
84galactose catabolic process (GO:0019388)2.94641881
85deoxyribonucleotide catabolic process (GO:0009264)2.93449047
86nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.93230513
87regulation of mitochondrial membrane potential (GO:0051881)2.93045832
88maturation of SSU-rRNA (GO:0030490)2.92783023
89proline biosynthetic process (GO:0006561)2.91437031
90transferrin transport (GO:0033572)2.90946473
91establishment of viral latency (GO:0019043)2.89053505
92L-methionine salvage (GO:0071267)2.89018666
93L-methionine biosynthetic process (GO:0071265)2.89018666
94amino acid salvage (GO:0043102)2.89018666
95base-excision repair, AP site formation (GO:0006285)2.86781776
96heme metabolic process (GO:0042168)2.86455352
97hydrogen peroxide metabolic process (GO:0042743)2.86320781
98sulfur amino acid catabolic process (GO:0000098)2.84773946
99phospholipid efflux (GO:0033700)2.83740286
100negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.81833424
101pyrimidine nucleoside biosynthetic process (GO:0046134)2.80623507
102CTP biosynthetic process (GO:0006241)2.80317838
103CTP metabolic process (GO:0046036)2.80317838
104antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.80297481
105nucleoside salvage (GO:0043174)2.77597108
106heart contraction (GO:0060047)2.75366594
107heart process (GO:0003015)2.75366594
108formation of translation preinitiation complex (GO:0001731)2.75202764
109termination of RNA polymerase III transcription (GO:0006386)2.74572971
110transcription elongation from RNA polymerase III promoter (GO:0006385)2.74572971
111nucleoside diphosphate biosynthetic process (GO:0009133)2.74127246
112mitochondrial respiratory chain complex assembly (GO:0033108)2.73853432
113hydrogen peroxide catabolic process (GO:0042744)2.73765089
114pyrimidine ribonucleoside biosynthetic process (GO:0046132)2.73526143
115phagosome maturation (GO:0090382)2.73369950
116mitochondrial calcium ion transport (GO:0006851)2.72443085
117antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.71800938
118deoxyribose phosphate catabolic process (GO:0046386)2.71698802
119serine family amino acid biosynthetic process (GO:0009070)2.71324805
120metallo-sulfur cluster assembly (GO:0031163)2.70879153
121iron-sulfur cluster assembly (GO:0016226)2.70879153
122ribonucleoside triphosphate biosynthetic process (GO:0009201)2.70756488
123DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.70586408
124pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.70129403
125positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.69695895
126aromatic amino acid family metabolic process (GO:0009072)2.69622088
127anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.69583329
128tryptophan catabolic process (GO:0006569)2.68697427
129indole-containing compound catabolic process (GO:0042436)2.68697427
130indolalkylamine catabolic process (GO:0046218)2.68697427
131peptidyl-histidine modification (GO:0018202)2.68121815
132virion assembly (GO:0019068)2.68001226
133signal transduction involved in DNA integrity checkpoint (GO:0072401)2.67216070
134signal transduction involved in DNA damage checkpoint (GO:0072422)2.67216070
135pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.66816382
136signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.66734492
137signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.66734492
138signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.66734492
139fructose metabolic process (GO:0006000)2.66209961
140triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.65926182
141protein complex disassembly (GO:0043241)2.65359015
142protein complex biogenesis (GO:0070271)2.65029974
143NADH metabolic process (GO:0006734)2.64900508
144kynurenine metabolic process (GO:0070189)2.64817981
145intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.64370855
146signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.64370855
147pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.63912630
148respiratory chain complex IV assembly (GO:0008535)2.62960478
149regulation of cellular respiration (GO:0043457)2.62726617
150tryptophan metabolic process (GO:0006568)2.62413722
151pyrimidine-containing compound biosynthetic process (GO:0072528)2.61932836
152signal transduction involved in cell cycle checkpoint (GO:0072395)2.61569988
153folic acid transport (GO:0015884)2.61282796
154glyoxylate metabolic process (GO:0046487)2.61091818
155* fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.60706373
156pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.60286978
157pyrimidine nucleotide biosynthetic process (GO:0006221)2.60265845
158ribonucleoprotein complex biogenesis (GO:0022613)2.59926187
159cellular metabolic compound salvage (GO:0043094)2.59664408
160folic acid-containing compound biosynthetic process (GO:0009396)2.59413340
161regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.59392695
162cellular component biogenesis (GO:0044085)2.59372475
163cytochrome complex assembly (GO:0017004)2.59136848
164negative regulation of ligase activity (GO:0051352)2.58429592
165negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.58429592
166positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.57211642

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.84096815
2MYC_18555785_ChIP-Seq_MESCs_Mouse3.33005771
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.21737741
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.11709517
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.09350185
6E2F7_22180533_ChIP-Seq_HELA_Human2.93707459
7ETS1_20019798_ChIP-Seq_JURKAT_Human2.77166330
8GABP_17652178_ChIP-ChIP_JURKAT_Human2.68210512
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.61419555
10CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.59991004
11* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.59377503
12ELF1_17652178_ChIP-ChIP_JURKAT_Human2.50483424
13NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.49731355
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.43972317
15TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.27914390
16IRF8_22096565_ChIP-ChIP_GC-B_Human2.21758504
17MYC_19079543_ChIP-ChIP_MESCs_Mouse2.14704290
18SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.13846528
19RXR_22158963_ChIP-Seq_LIVER_Mouse2.07948381
20CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.04596224
21MYC_19030024_ChIP-ChIP_MESCs_Mouse2.02197804
22* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.01768070
23E2F1_18555785_ChIP-Seq_MESCs_Mouse2.01378143
24HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.00673038
25VDR_23849224_ChIP-Seq_CD4+_Human2.00015398
26XRN2_22483619_ChIP-Seq_HELA_Human1.98091902
27PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.96564978
28ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.96290216
29DCP1A_22483619_ChIP-Seq_HELA_Human1.92289845
30* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.84753931
31SRF_21415370_ChIP-Seq_HL-1_Mouse1.82494986
32CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.82151663
33CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.81941363
34CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.81893781
35FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.79856183
36EGR1_23403033_ChIP-Seq_LIVER_Mouse1.79842724
37LXR_22292898_ChIP-Seq_THP-1_Human1.77613049
38YY1_21170310_ChIP-Seq_MESCs_Mouse1.76343246
39E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.75313489
40* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.73258092
41IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.71642771
42FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.71352559
43DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.70925719
44TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.67889358
45ZNF263_19887448_ChIP-Seq_K562_Human1.66947898
46SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.65113846
47* GABP_19822575_ChIP-Seq_HepG2_Human1.64186580
48FOXP3_21729870_ChIP-Seq_TREG_Human1.62202354
49* PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.59987853
50STAT3_1855785_ChIP-Seq_MESCs_Mouse1.56086834
51HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.55925440
52RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.49800876
53NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.48010969
54THAP11_20581084_ChIP-Seq_MESCs_Mouse1.45552530
55* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.42970990
56HOXB4_20404135_ChIP-ChIP_EML_Mouse1.41833781
57SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.39998920
58BCOR_27268052_Chip-Seq_Bcells_Human1.39267763
59CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.39134551
60ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.38947788
61BCL6_27268052_Chip-Seq_Bcells_Human1.38270262
62P68_20966046_ChIP-Seq_HELA_Human1.37445060
63* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.36965761
64TTF2_22483619_ChIP-Seq_HELA_Human1.33812479
65RARG_19884340_ChIP-ChIP_MEFs_Mouse1.32893751
66POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.32118431
67ERG_20887958_ChIP-Seq_HPC-7_Mouse1.31699580
68CIITA_25753668_ChIP-Seq_RAJI_Human1.31508525
69SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.29589701
70SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.27620274
71SRY_22984422_ChIP-ChIP_TESTIS_Rat1.25161042
72MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.23958074
73FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.22282324
74FOXP1_21924763_ChIP-Seq_HESCs_Human1.22260928
75RACK7_27058665_Chip-Seq_MCF-7_Human1.22253104
76VDR_21846776_ChIP-Seq_THP-1_Human1.22189371
77ELK3_25401928_ChIP-Seq_HUVEC_Human1.21163108
78TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.20913795
79MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.18905524
80GATA1_22383799_ChIP-Seq_G1ME_Mouse1.18231280
81NANOG_18555785_ChIP-Seq_MESCs_Mouse1.17425701
82SPI1_23547873_ChIP-Seq_NB4_Human1.17075548
83MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.16910646
84SA1_27219007_Chip-Seq_ERYTHROID_Human1.16445029
85FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.14972907
86BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.14922328
87* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.14103854
88LXR_22158963_ChIP-Seq_LIVER_Mouse1.13021690
89IRF8_21731497_ChIP-ChIP_J774_Mouse1.12971207
90SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.12145161
91MYC_22102868_ChIP-Seq_BL_Human1.11976879
92BP1_19119308_ChIP-ChIP_Hs578T_Human1.11619719
93* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.10727076
94THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.08577120
95CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.08421917
96TBX5_21415370_ChIP-Seq_HL-1_Mouse1.08184370
97CTCF_18555785_ChIP-Seq_MESCs_Mouse1.07883855
98ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.06359675
99CTCF_27219007_Chip-Seq_ERYTHROID_Human1.06243153
100MYB_21317192_ChIP-Seq_ERMYB_Mouse1.06211408
101NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.06076029
102PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.05904061
103PHF8_20622854_ChIP-Seq_HELA_Human1.05612132
104SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.05507676
105E2F4_17652178_ChIP-ChIP_JURKAT_Human1.04801258
106STAT4_19710469_ChIP-ChIP_TH1__Mouse1.04797272
107GATA1_22025678_ChIP-Seq_K562_Human1.04433575
108* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.03532835
109CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.03482214
110MAF_26560356_Chip-Seq_TH2_Human1.02439334
111CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.02379118
112DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.01490498
113TFEB_21752829_ChIP-Seq_HELA_Human1.01453042
114HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.01009326
115EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.00649320
116SA1_27219007_Chip-Seq_Bcells_Human1.00573458
117ZFX_18555785_ChIP-Seq_MESCs_Mouse1.00481809
118YY1_22570637_ChIP-Seq_MALME-3M_Human1.00266877
119CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99584331
120* PU.1_20513432_ChIP-Seq_Bcells_Mouse0.99340511
121ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.98249624
122MYCN_18555785_ChIP-Seq_MESCs_Mouse0.96709700
123TET1_21451524_ChIP-Seq_MESCs_Mouse0.94369459
124ELK1_19687146_ChIP-ChIP_HELA_Human0.94116330
125KDM5A_27292631_Chip-Seq_BREAST_Human0.92461126
126ELF1_20517297_ChIP-Seq_JURKAT_Human0.92133030
127CTCF_26484167_Chip-Seq_Bcells_Mouse0.91655657
128SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.90270601
129OCT4_18692474_ChIP-Seq_MEFs_Mouse0.90206891
130LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.89291558

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.41279468
2MP0005360_urolithiasis4.34333923
3MP0003806_abnormal_nucleotide_metabolis4.32095101
4MP0003693_abnormal_embryo_hatching4.11773417
5MP0000372_irregular_coat_pigmentation3.66734633
6MP0009840_abnormal_foam_cell3.20820359
7MP0005085_abnormal_gallbladder_physiolo3.08822754
8MP0005365_abnormal_bile_salt3.06979034
9MP0004145_abnormal_muscle_electrophysio2.73185221
10MP0008875_abnormal_xenobiotic_pharmacok2.55211833
11MP0003186_abnormal_redox_activity2.34261464
12MP0006036_abnormal_mitochondrial_physio2.33976699
13MP0003656_abnormal_erythrocyte_physiolo2.22481629
14MP0005332_abnormal_amino_acid2.20979870
15MP0000751_myopathy2.14917296
16MP0003191_abnormal_cellular_cholesterol2.05488939
17MP0009697_abnormal_copulation2.05421066
18MP0000749_muscle_degeneration2.03580297
19MP0010329_abnormal_lipoprotein_level2.00391846
20MP0004510_myositis1.95368534
21MP0003136_yellow_coat_color1.94843936
22MP0000750_abnormal_muscle_regeneration1.94135818
23MP0005423_abnormal_somatic_nervous1.90237791
24MP0001835_abnormal_antigen_presentation1.89088525
25MP0001764_abnormal_homeostasis1.86833812
26MP0004957_abnormal_blastocyst_morpholog1.84902361
27MP0009785_altered_susceptibility_to1.78108123
28MP0003436_decreased_susceptibility_to1.77189357
29MP0001666_abnormal_nutrient_absorption1.73852472
30MP0002822_catalepsy1.71556449
31MP0001986_abnormal_taste_sensitivity1.70823699
32MP0004147_increased_porphyrin_level1.67420173
33MP0003646_muscle_fatigue1.67303989
34MP0003866_abnormal_defecation1.64402221
35MP0005083_abnormal_biliary_tract1.63655391
36MP0000685_abnormal_immune_system1.60477787
37MP0004270_analgesia1.59739127
38MP0009643_abnormal_urine_homeostasis1.59051228
39MP0009379_abnormal_foot_pigmentation1.56276213
40MP0009333_abnormal_splenocyte_physiolog1.55604516
41MP0004019_abnormal_vitamin_homeostasis1.54506564
42MP0003075_altered_response_to1.53908522
43MP0000609_abnormal_liver_physiology1.53452911
44MP0003111_abnormal_nucleus_morphology1.53342128
45MP0000015_abnormal_ear_pigmentation1.52547953
46MP0005025_abnormal_response_to1.50062706
47MP0001529_abnormal_vocalization1.47506168
48MP0003724_increased_susceptibility_to1.46606681
49MP0000747_muscle_weakness1.45474675
50MP0003123_paternal_imprinting1.44404035
51MP0005330_cardiomyopathy1.43735653
52MP0010094_abnormal_chromosome_stability1.42777192
53MP0001853_heart_inflammation1.42773703
54MP0005319_abnormal_enzyme/_coenzyme1.41593151
55MP0003077_abnormal_cell_cycle1.40423302
56MP0008469_abnormal_protein_level1.38754903
57MP0005671_abnormal_response_to1.38623960
58MP0003718_maternal_effect1.38397125
59MP0002148_abnormal_hypersensitivity_rea1.38325188
60MP0005464_abnormal_platelet_physiology1.37998302
61MP0006035_abnormal_mitochondrial_morpho1.35660094
62MP0005636_abnormal_mineral_homeostasis1.35343297
63MP0000358_abnormal_cell_content/1.28340161
64MP0001845_abnormal_inflammatory_respons1.28167565
65MP0005584_abnormal_enzyme/coenzyme_acti1.28164839
66MP0002419_abnormal_innate_immunity1.27188275
67MP0004859_abnormal_synaptic_plasticity1.26966031
68MP0001800_abnormal_humoral_immune1.25850010
69MP0005000_abnormal_immune_tolerance1.22877549
70MP0002723_abnormal_immune_serum1.22737912
71MP0002106_abnormal_muscle_physiology1.21103783
72MP0001756_abnormal_urination1.19130897
73MP0002277_abnormal_respiratory_mucosa1.18115234
74MP0005075_abnormal_melanosome_morpholog1.17413018
75MP0000343_altered_response_to1.15747340
76MP0008995_early_reproductive_senescence1.15318604
77MP0000689_abnormal_spleen_morphology1.15281336
78MP0003195_calcinosis1.13734324
79MP0002452_abnormal_antigen_presenting1.13339790
80MP0005408_hypopigmentation1.12553382
81MP0001819_abnormal_immune_cell1.12405427
82MP0002420_abnormal_adaptive_immunity1.12052386
83MP0002396_abnormal_hematopoietic_system1.11633691
84MP0002332_abnormal_exercise_endurance1.11250165
85MP0005058_abnormal_lysosome_morphology1.10329074
86MP0002398_abnormal_bone_marrow1.09479423
87MP0005165_increased_susceptibility_to1.08847234
88MP0000490_abnormal_crypts_of1.08721861
89MP0002722_abnormal_immune_system1.08572666
90MP0003183_abnormal_peptide_metabolism1.08217509
91MP0006082_CNS_inflammation1.07895724
92MP0010155_abnormal_intestine_physiology1.07845513
93MP0008932_abnormal_embryonic_tissue1.07772596
94MP0002653_abnormal_ependyma_morphology1.07553622
95MP0003252_abnormal_bile_duct1.07058559
96MP0000716_abnormal_immune_system1.04725610
97MP0002429_abnormal_blood_cell1.04263034
98MP0002118_abnormal_lipid_homeostasis1.03485499
99MP0003763_abnormal_thymus_physiology1.02828756
100MP0001661_extended_life_span1.02000666
101MP0003172_abnormal_lysosome_physiology1.01740026
102MP0002019_abnormal_tumor_incidence1.00720889
103MP0005451_abnormal_body_composition1.00135875
104MP0001545_abnormal_hematopoietic_system0.99220314
105MP0005397_hematopoietic_system_phenotyp0.99220314
106MP0005387_immune_system_phenotype0.98885678
107MP0001790_abnormal_immune_system0.98885678
108MP0000598_abnormal_liver_morphology0.98037837
109MP0008004_abnormal_stomach_pH0.97986276
110MP0008260_abnormal_autophagy0.97767139
111MP0009764_decreased_sensitivity_to0.97648515
112MP0002735_abnormal_chemical_nociception0.97467897
113MP0005645_abnormal_hypothalamus_physiol0.97092409
114MP0002405_respiratory_system_inflammati0.95225142
115MP0002136_abnormal_kidney_physiology0.92762145
116MP0003329_amyloid_beta_deposits0.91826083
117MP0009763_increased_sensitivity_to0.91580289
118MP0000858_altered_metastatic_potential0.90988227
119MP0009642_abnormal_blood_homeostasis0.90352831
120MP0008058_abnormal_DNA_repair0.90315023
121MP0005166_decreased_susceptibility_to0.90121156
122MP0008873_increased_physiological_sensi0.89900127
123MP0008872_abnormal_physiological_respon0.87816177
124MP0004808_abnormal_hematopoietic_stem0.87346947
125MP0002876_abnormal_thyroid_physiology0.85393008
126MP0002064_seizures0.85207988
127MP0008874_decreased_physiological_sensi0.84952811
128MP0001730_embryonic_growth_arrest0.84761217
129MP0002132_abnormal_respiratory_system0.84585648
130MP0001849_ear_inflammation0.83881167
131MP0003786_premature_aging0.82861431
132MP0003879_abnormal_hair_cell0.80108314
133MP0005670_abnormal_white_adipose0.79857585
134MP0002090_abnormal_vision0.79166765
135MP0000604_amyloidosis0.79049271
136MP0002095_abnormal_skin_pigmentation0.78961873
137MP0001188_hyperpigmentation0.78821150
138MP0002138_abnormal_hepatobiliary_system0.78740569
139MP0008007_abnormal_cellular_replicative0.78692463
140MP0003011_delayed_dark_adaptation0.78597964
141MP0009046_muscle_twitch0.77478572
142MP0001905_abnormal_dopamine_level0.77229641
143MP0000759_abnormal_skeletal_muscle0.77003015
144MP0001970_abnormal_pain_threshold0.76232429
145MP0002163_abnormal_gland_morphology0.75946152
146MP0005266_abnormal_metabolism0.74003042
147MP0002972_abnormal_cardiac_muscle0.73287658
148MP0001873_stomach_inflammation0.71667378
149MP0008569_lethality_at_weaning0.70471407
150MP0004142_abnormal_muscle_tone0.70443625
151MP0005501_abnormal_skin_physiology0.69043340
152MP0008789_abnormal_olfactory_epithelium0.68292049
153MP0005369_muscle_phenotype0.66722823
154MP0002734_abnormal_mechanical_nocicepti0.66218111
155MP0003638_abnormal_response/metabolism_0.65973750
156MP0009765_abnormal_xenobiotic_induced0.65431885
157MP0002269_muscular_atrophy0.63333615
158MP0004036_abnormal_muscle_relaxation0.59902918
159MP0002733_abnormal_thermal_nociception0.58599981

Predicted human phenotypes

RankGene SetZ-score
1Conjugated hyperbilirubinemia (HP:0002908)5.91949995
2Vacuolated lymphocytes (HP:0001922)5.48064257
3Abnormal mitochondria in muscle tissue (HP:0008316)5.43638811
4Acute necrotizing encephalopathy (HP:0006965)5.20672053
5Abnormality of aromatic amino acid family metabolism (HP:0004338)5.10338323
6Abnormal gallbladder physiology (HP:0012438)4.73904120
7Cholecystitis (HP:0001082)4.73904120
8Progressive macrocephaly (HP:0004481)4.20022129
9Increased intramyocellular lipid droplets (HP:0012240)3.96876134
10Abnormality of cells of the erythroid lineage (HP:0012130)3.66865125
11Abnormality of glycolysis (HP:0004366)3.62375915
12Hepatic necrosis (HP:0002605)3.44892186
13Hepatocellular necrosis (HP:0001404)3.40860237
14Multiple enchondromatosis (HP:0005701)3.39891728
15J-shaped sella turcica (HP:0002680)3.36297691
16Exercise intolerance (HP:0003546)3.35452097
17Hypobetalipoproteinemia (HP:0003563)3.31799381
18Renal Fanconi syndrome (HP:0001994)3.23001686
19Abnormality of monocarboxylic acid metabolism (HP:0010996)3.17229985
20Increased serum pyruvate (HP:0003542)3.14482914
21Popliteal pterygium (HP:0009756)3.14046136
22Hyperglycinuria (HP:0003108)3.13278556
23Increased hepatocellular lipid droplets (HP:0006565)3.12432973
24Abnormal number of erythroid precursors (HP:0012131)3.11953703
25Respiratory failure (HP:0002878)3.08372118
26Ragged-red muscle fibers (HP:0003200)3.04967516
27Rhabdomyolysis (HP:0003201)3.03618733
28Hyperbilirubinemia (HP:0002904)2.90280481
29Spastic paraparesis (HP:0002313)2.81832411
30Prolonged partial thromboplastin time (HP:0003645)2.79909596
31Distal lower limb muscle weakness (HP:0009053)2.74036360
32Rough bone trabeculation (HP:0100670)2.73282557
33Intrahepatic cholestasis (HP:0001406)2.67396633
34Myokymia (HP:0002411)2.66963770
35Abnormality of glycine metabolism (HP:0010895)2.66276583
36Abnormality of serine family amino acid metabolism (HP:0010894)2.66276583
37Macrocytic anemia (HP:0001972)2.63969779
38Abnormality of fatty-acid metabolism (HP:0004359)2.63511473
39Cholelithiasis (HP:0001081)2.62532344
40Respiratory difficulties (HP:0002880)2.59838698
41Xanthomatosis (HP:0000991)2.58756904
42Hyperglycinemia (HP:0002154)2.56593073
43Hyperammonemia (HP:0001987)2.55957370
44IgM deficiency (HP:0002850)2.53836819
45Opisthotonus (HP:0002179)2.53008391
46Abnormality of dicarboxylic acid metabolism (HP:0010995)2.49894113
47Dicarboxylic aciduria (HP:0003215)2.49894113
48Purpura (HP:0000979)2.49818928
49Abnormality of sulfur amino acid metabolism (HP:0004339)2.48068577
50Abnormality of pyrimidine metabolism (HP:0004353)2.46347035
51Aplastic anemia (HP:0001915)2.41065566
52Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.39977949
53Mitochondrial inheritance (HP:0001427)2.37422957
54Lethargy (HP:0001254)2.35140124
55Myopathic facies (HP:0002058)2.33661656
56Decreased activity of mitochondrial respiratory chain (HP:0008972)2.33618198
57Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.33618198
58Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.33341308
59Short nail (HP:0001799)2.32895238
60Abnormal gallbladder morphology (HP:0012437)2.32649827
61Reduced antithrombin III activity (HP:0001976)2.30192655
62Thrombocytosis (HP:0001894)2.29969489
633-Methylglutaconic aciduria (HP:0003535)2.28836816
64Abnormality of methionine metabolism (HP:0010901)2.26428527
65Leukodystrophy (HP:0002415)2.26125130
66Abnormality of glutamine family amino acid metabolism (HP:0010902)2.25977863
67X-linked dominant inheritance (HP:0001423)2.25144117
68Nemaline bodies (HP:0003798)2.24754596
69Increased CSF lactate (HP:0002490)2.23905676
70Increased serum lactate (HP:0002151)2.23716217
71Hyperlipoproteinemia (HP:0010980)2.22803565
72Pallor (HP:0000980)2.22123558
73Reticulocytopenia (HP:0001896)2.21007058
74Ketosis (HP:0001946)2.20347154
75Recurrent gram-negative bacterial infections (HP:0005420)2.19350794
76Abnormality of aspartate family amino acid metabolism (HP:0010899)2.18351679
77Abnormality of the preputium (HP:0100587)2.18106315
78Deep venous thrombosis (HP:0002625)2.17761256
79Hypoglycemic coma (HP:0001325)2.17534287
80CNS demyelination (HP:0007305)2.15604938
81Abnormal trabecular bone morphology (HP:0100671)2.15580896
82Generalized aminoaciduria (HP:0002909)2.15479301
83Late onset (HP:0003584)2.15129958
84Cerebral palsy (HP:0100021)2.14878330
85Cerebral edema (HP:0002181)2.12934020
86Exercise-induced myalgia (HP:0003738)2.12462086
87Mutism (HP:0002300)2.12268474
88Muscle fiber splitting (HP:0003555)2.12250328
89Muscle fiber inclusion bodies (HP:0100299)2.10689022
90Gout (HP:0001997)2.08663319
91Type I transferrin isoform profile (HP:0003642)2.08366501
92Ankle clonus (HP:0011448)2.08130209
93Megaloblastic anemia (HP:0001889)2.07992903
94Abnormality of nucleobase metabolism (HP:0010932)2.07402365
95Abnormal hemoglobin (HP:0011902)2.07391101
96Entropion (HP:0000621)2.07289847
97Progressive external ophthalmoplegia (HP:0000590)2.07143954
98Poikiloderma (HP:0001029)2.06896693
99Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.06815209
100Oral leukoplakia (HP:0002745)2.06124627
101Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.03755305
102Hypolipoproteinemia (HP:0010981)2.03008996
103Abnormal platelet function (HP:0011869)2.02929815
104Impaired platelet aggregation (HP:0003540)2.02929815
105Hepatosplenomegaly (HP:0001433)2.02544051
106Delusions (HP:0000746)2.02426925
107Recurrent bacterial skin infections (HP:0005406)2.01331934
108Fat malabsorption (HP:0002630)2.01173562
109Petechiae (HP:0000967)2.00727142
110Poor head control (HP:0002421)2.00718764
111Oligomenorrhea (HP:0000876)1.98693338
112Gliosis (HP:0002171)1.97850458
113Abnormality of the heme biosynthetic pathway (HP:0010472)1.97743450
114Abnormality of macrophages (HP:0004311)1.96989730
115Lipid accumulation in hepatocytes (HP:0006561)1.96756266
116Methylmalonic aciduria (HP:0012120)1.96691655
117Exertional dyspnea (HP:0002875)1.96559736
118Myoglobinuria (HP:0002913)1.96367139
119Death in childhood (HP:0003819)1.94529057
120Recurrent abscess formation (HP:0002722)1.94006398
121Optic disc pallor (HP:0000543)1.93910735
122Lactic acidosis (HP:0003128)1.93519548
123Mesangial abnormality (HP:0001966)1.93232105
124Deformed sella turcica (HP:0002681)1.91586743
125Fair hair (HP:0002286)1.91164627
126Acute encephalopathy (HP:0006846)1.89798108
127Metabolic acidosis (HP:0001942)1.89108127
128Eczematoid dermatitis (HP:0000976)1.89018419
129Abnormal cartilage morphology (HP:0002763)1.88307653
130Abnormality of purine metabolism (HP:0004352)1.87930030
131Emotional lability (HP:0000712)1.86686808
132Abnormality of urine glucose concentration (HP:0011016)1.85981294
133Glycosuria (HP:0003076)1.85981294
134Abnormality of the anterior horn cell (HP:0006802)1.85363980
135Degeneration of anterior horn cells (HP:0002398)1.85363980
136Meckel diverticulum (HP:0002245)1.84644447
137Patellar aplasia (HP:0006443)1.83583982
138Vertebral compression fractures (HP:0002953)1.83582621
139Athetosis (HP:0002305)1.82131385
140Nausea (HP:0002018)1.82091705
141Microretrognathia (HP:0000308)1.81706561
142Increased muscle lipid content (HP:0009058)1.81556488
143Paraparesis (HP:0002385)1.81075644
144Abnormality of serum amino acid levels (HP:0003112)1.80860112
145Cerebral hypomyelination (HP:0006808)1.80514452
146Hypokinesia (HP:0002375)1.80161140
147Joint hemorrhage (HP:0005261)1.79663004
148Abnormality of the gallbladder (HP:0005264)1.79571564
149Muscle fibrillation (HP:0010546)1.79262850
150Fasciculations (HP:0002380)1.76583263
151Severe visual impairment (HP:0001141)1.76381671
152Visual hallucinations (HP:0002367)1.76077465
153Neuronal loss in central nervous system (HP:0002529)1.75285822
154Tongue fasciculations (HP:0001308)1.74200471
155Microvesicular hepatic steatosis (HP:0001414)1.74123317
156Increased serum ferritin (HP:0003281)1.71834241
157Exercise-induced muscle cramps (HP:0003710)1.68240280
158Growth hormone excess (HP:0000845)1.67749719
159Polyphagia (HP:0002591)1.67111914
160Axonal loss (HP:0003447)1.66364433
161Muscle stiffness (HP:0003552)1.66083523
162Large for gestational age (HP:0001520)1.65956084
163Prolonged bleeding time (HP:0003010)1.65541938
164Loss of speech (HP:0002371)1.64745641
165Obstructive lung disease (HP:0006536)1.64566570
166Chronic obstructive pulmonary disease (HP:0006510)1.64566570
167Dysostosis multiplex (HP:0000943)1.64358221

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME26.23859972
2VRK24.47124180
3BUB14.35010428
4PIM23.78567456
5GRK52.99335811
6NME12.87053921
7BCKDK2.54137848
8WEE12.46607840
9CDK192.32718364
10PRKD32.30258287
11TESK22.29701080
12STK162.28731270
13MAPKAPK32.21954349
14SRPK12.13562512
15BRSK22.13481969
16ARAF2.01075733
17MAP4K11.90529381
18TESK11.85645023
19RPS6KB21.75337926
20TAOK21.74650516
21MAP3K121.71587059
22CAMKK21.53990022
23ZAP701.49888059
24KDR1.48379198
25PHKG11.47486210
26PHKG21.47486210
27EIF2AK31.45369338
28IRAK31.43314406
29EPHA21.41281432
30TSSK61.40313755
31ILK1.38593189
32PRPF4B1.37817603
33FLT31.32231233
34EIF2AK11.31551695
35MAP3K111.30046801
36MAP3K61.27628188
37PAK61.26951760
38BRSK11.25990388
39TYK21.25476119
40ACVR1B1.21059411
41ERN11.19825899
42LMTK21.14455003
43ZAK1.13902785
44RIPK41.10297435
45IRAK41.08719659
46LIMK11.08499697
47MUSK1.08458693
48OBSCN1.07878699
49BTK1.06836302
50PBK1.05256610
51TEC1.04653729
52GRK61.03965155
53PRKG21.00243047
54PIM10.99509879
55VRK10.99028515
56ABL20.99000274
57CSNK1G30.97067502
58DAPK10.96028450
59MAP2K30.95769388
60TBK10.94874537
61LRRK20.93064233
62SMG10.87752066
63KIT0.84360232
64AURKA0.80803673
65BRAF0.79584062
66PKN20.78851529
67BMX0.76496908
68TNK20.75890264
69TLK10.73325712
70CAMK2G0.73314256
71NEK20.72870655
72CSNK1A1L0.72240102
73BLK0.72093716
74PLK40.70933894
75CDK80.69932775
76AKT30.69329112
77TXK0.68684496
78NEK10.68346549
79SCYL20.67763200
80PAK40.65965050
81DAPK30.65867153
82TIE10.65358674
83MST40.65260848
84RAF10.65250207
85DYRK20.65191785
86RPS6KA50.64595166
87SYK0.62368273
88STK100.60884101
89MAP2K70.60846891
90CSNK1G20.60803445
91AKT20.60675100
92TRIB30.60657430
93MAPK120.58378246
94MAP3K30.58146915
95LYN0.56893416
96MATK0.55471864
97CSNK1G10.53718825
98PIK3CG0.53017545
99IKBKB0.52622116
100AURKB0.52375419
101PLK10.51328622
102DAPK20.50516031
103TAOK30.50133956
104CAMK2D0.49905488
105CDK140.49486426
106PKN10.49152949
107STK240.46819673
108DYRK30.46027005
109MAPK40.45465621
110PAK10.44124590
111PRKD10.43751838
112PASK0.43063199
113IKBKE0.42371056
114MYLK0.42216391
115TAOK10.41991885
116IRAK10.41444372
117PTK2B0.40868290
118CDK70.39976368
119DYRK1B0.39738219
120MAP2K60.39619153
121KSR20.38160103
122CSNK2A10.38057241
123CSF1R0.37895139
124PRKCI0.37867550
125EEF2K0.36436764
126CAMKK10.36045104
127JAK20.35373704
128MAP3K10.35236799
129EPHB10.34592056
130CDK11A0.34497734
131MST1R0.33800220
132CCNB10.33715750
133MARK20.33113094
134TTN0.32714615
135CSNK2A20.32587246
136ATR0.32178919
137MAPK110.30461064
138HIPK20.30081343
139CSK0.29328323
140MINK10.29038643
141SIK30.28758315
142PRKCD0.28750772
143FGFR40.28688480
144MAP3K80.28624039
145MAP3K50.28295367
146SIK10.27731100
147PDK20.26479061

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030103.66881267
2Proteasome_Homo sapiens_hsa030502.88687044
3RNA polymerase_Homo sapiens_hsa030202.62102561
4Folate biosynthesis_Homo sapiens_hsa007902.56239928
5Pyrimidine metabolism_Homo sapiens_hsa002402.33344305
6DNA replication_Homo sapiens_hsa030302.28981465
7* Primary bile acid biosynthesis_Homo sapiens_hsa001202.15899202
8Vibrio cholerae infection_Homo sapiens_hsa051102.04591616
9Drug metabolism - other enzymes_Homo sapiens_hsa009832.03280725
10Pentose phosphate pathway_Homo sapiens_hsa000301.99569852
11Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.96415923
12Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.82894688
13Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.81587063
14Fructose and mannose metabolism_Homo sapiens_hsa000511.79177166
15Synaptic vesicle cycle_Homo sapiens_hsa047211.77254748
16Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.74984063
17Oxidative phosphorylation_Homo sapiens_hsa001901.73524205
18Pentose and glucuronate interconversions_Homo sapiens_hsa000401.70830474
19Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.69927535
20Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.67501957
21Parkinsons disease_Homo sapiens_hsa050121.64410331
22Cardiac muscle contraction_Homo sapiens_hsa042601.62736997
23Protein export_Homo sapiens_hsa030601.62447184
24Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.56532704
25Caffeine metabolism_Homo sapiens_hsa002321.56044212
26Sulfur relay system_Homo sapiens_hsa041221.55944794
27Nucleotide excision repair_Homo sapiens_hsa034201.55257197
282-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.53252845
29Tryptophan metabolism_Homo sapiens_hsa003801.48763658
30* Peroxisome_Homo sapiens_hsa041461.47220119
31Cysteine and methionine metabolism_Homo sapiens_hsa002701.46884082
32Histidine metabolism_Homo sapiens_hsa003401.46830638
33Fatty acid degradation_Homo sapiens_hsa000711.44928560
34Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.41387238
35Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.39959595
36Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.38413843
37Vitamin B6 metabolism_Homo sapiens_hsa007501.35163853
38Selenocompound metabolism_Homo sapiens_hsa004501.33583966
39beta-Alanine metabolism_Homo sapiens_hsa004101.31411766
40Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.30928469
41Base excision repair_Homo sapiens_hsa034101.29954378
42Mismatch repair_Homo sapiens_hsa034301.28255900
43Biosynthesis of amino acids_Homo sapiens_hsa012301.27066628
44One carbon pool by folate_Homo sapiens_hsa006701.25785242
45Phenylalanine metabolism_Homo sapiens_hsa003601.25344236
46Regulation of autophagy_Homo sapiens_hsa041401.24910113
47Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.22811224
48Arginine biosynthesis_Homo sapiens_hsa002201.21834700
49Carbon metabolism_Homo sapiens_hsa012001.20382123
50Glutathione metabolism_Homo sapiens_hsa004801.17171042
51Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.15253080
52Sulfur metabolism_Homo sapiens_hsa009201.12103475
53Huntingtons disease_Homo sapiens_hsa050161.11278013
54Spliceosome_Homo sapiens_hsa030401.10538048
55Maturity onset diabetes of the young_Homo sapiens_hsa049501.09596206
56Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.06876848
57Purine metabolism_Homo sapiens_hsa002301.03780610
58Chemical carcinogenesis_Homo sapiens_hsa052041.02094298
59Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.01144696
60Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.95655358
61Complement and coagulation cascades_Homo sapiens_hsa046100.94747752
62Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.94547644
63Galactose metabolism_Homo sapiens_hsa000520.92840619
64Vitamin digestion and absorption_Homo sapiens_hsa049770.89929725
65Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.88962704
66Cyanoamino acid metabolism_Homo sapiens_hsa004600.87673323
67RNA transport_Homo sapiens_hsa030130.87215560
68Pyruvate metabolism_Homo sapiens_hsa006200.84644211
69Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.84542206
70Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.84460878
71Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.82921134
72* Metabolic pathways_Homo sapiens_hsa011000.82632621
73Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.82188137
74Butanoate metabolism_Homo sapiens_hsa006500.81894159
75Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.80460310
76Tyrosine metabolism_Homo sapiens_hsa003500.80101983
77SNARE interactions in vesicular transport_Homo sapiens_hsa041300.79718370
78Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.79043746
79Starch and sucrose metabolism_Homo sapiens_hsa005000.76881591
80Alzheimers disease_Homo sapiens_hsa050100.76337959
81PPAR signaling pathway_Homo sapiens_hsa033200.74497932
82Staphylococcus aureus infection_Homo sapiens_hsa051500.73119486
83Arginine and proline metabolism_Homo sapiens_hsa003300.71166952
84Other glycan degradation_Homo sapiens_hsa005110.69808153
85Propanoate metabolism_Homo sapiens_hsa006400.69072379
86Glycosaminoglycan degradation_Homo sapiens_hsa005310.68268846
87Fatty acid metabolism_Homo sapiens_hsa012120.67487454
88Fatty acid elongation_Homo sapiens_hsa000620.66740363
89ABC transporters_Homo sapiens_hsa020100.66176780
90Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.66116067
91Fat digestion and absorption_Homo sapiens_hsa049750.65908464
92Alcoholism_Homo sapiens_hsa050340.63767332
93Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.59736052
94Homologous recombination_Homo sapiens_hsa034400.58529172
95Fanconi anemia pathway_Homo sapiens_hsa034600.58201358
96N-Glycan biosynthesis_Homo sapiens_hsa005100.57154545
97Primary immunodeficiency_Homo sapiens_hsa053400.56129614
98p53 signaling pathway_Homo sapiens_hsa041150.55997165
99Retinol metabolism_Homo sapiens_hsa008300.54478006
100Antigen processing and presentation_Homo sapiens_hsa046120.53423304
101Legionellosis_Homo sapiens_hsa051340.49229186
102Endocytosis_Homo sapiens_hsa041440.47735670
103Bile secretion_Homo sapiens_hsa049760.47188201
104Lysosome_Homo sapiens_hsa041420.46735806
105Collecting duct acid secretion_Homo sapiens_hsa049660.46256264
106Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.46222549
107Cell cycle_Homo sapiens_hsa041100.45074537
108Epstein-Barr virus infection_Homo sapiens_hsa051690.45048005
109Renin-angiotensin system_Homo sapiens_hsa046140.43135585
110Steroid biosynthesis_Homo sapiens_hsa001000.41436161
111Steroid hormone biosynthesis_Homo sapiens_hsa001400.39685925
112Nitrogen metabolism_Homo sapiens_hsa009100.35837878
113Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.34518754
114Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.33184734
115Basal transcription factors_Homo sapiens_hsa030220.32646998
116Systemic lupus erythematosus_Homo sapiens_hsa053220.32347369
117Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.30565374
118Phagosome_Homo sapiens_hsa041450.29709022
119Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.26701965
120Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.24187446
121Shigellosis_Homo sapiens_hsa051310.22061620
122Rheumatoid arthritis_Homo sapiens_hsa053230.19960006
123Salmonella infection_Homo sapiens_hsa051320.18406738
124Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.16664275
125Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.12154336
126Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.05196547

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